lower gastrointestinal tract

Summary

Summary: The segment of GASTROINTESTINAL TRACT that includes the small intestine below the DUODENUM, and the LARGE INTESTINE.

Top Publications

  1. Barnert J, Messmann H. Management of lower gastrointestinal tract bleeding. Best Pract Res Clin Gastroenterol. 2008;22:295-312 pubmed publisher
    ..Angiography and nuclear scintigraphy are reserved for those patients in whom colonoscopy is not possible or has repeatedly failed to localise the bleeding site...
  2. Talley N, Quan C, Jones M, Horowitz M. Association of upper and lower gastrointestinal tract symptoms with body mass index in an Australian cohort. Neurogastroenterol Motil. 2004;16:413-9 pubmed
    ..01). Heartburn and diarrhoea were associated with increased BMI, while early satiety was associated with a lower BMI in this population...
  3. Gunawardene A, Corfe B, Staton C. Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. Int J Exp Pathol. 2011;92:219-31 pubmed publisher
    ..Nonetheless, their presence and diversity are indicative of a role. This review focuses on the EECs of the lower GI where new evidence also suggests a possible relationship with the development and progression of primary adenocarcinoma...
  4. Benderska N, Chakilam S, Hugle M, Ivanovska J, Gandesiri M, Schulze Luhrmann J, et al. Apoptosis signalling activated by TNF in the lower gastrointestinal tract--review. Curr Pharm Biotechnol. 2012;13:2248-58 pubmed
    ..Whether the described strategies will achieve the success of incorporating TNF in lower gastrointestinal tract therapy for inflammatory diseases and cancer remains to be determined.
  5. Raithel M, Baenkler H, Naegel A, Buchwald F, Schultis H, Backhaus B, et al. Significance of salicylate intolerance in diseases of the lower gastrointestinal tract. J Physiol Pharmacol. 2005;56 Suppl 5:89-102 pubmed
  6. Quigley K, Place H. The role of debridement and antibiotics in gunshot wounds to the spine. J Trauma. 2006;60:814-9; discussion 819-20 pubmed
    ..Spine and wound infections pose difficult problems for transgastrointestinal gunshot wounds to the spine...
  7. Marti M, Artigas J, Garzón G, Alvarez Sala R, Soto J. Acute lower intestinal bleeding: feasibility and diagnostic performance of CT angiography. Radiology. 2012;262:109-16 pubmed publisher
    ..To assess the diagnostic performance of computed tomographic (CT) angiography as the initial diagnostic examination for patients presenting to the emergency room with acute lower intestinal bleeding...
  8. Spanakis E, Kourkoumpetis T, Livanis G, Peleg A, Mylonakis E. Statin therapy and decreased incidence of positive Candida cultures among patients with type 2 diabetes mellitus undergoing gastrointestinal surgery. Mayo Clin Proc. 2010;85:1073-9 pubmed publisher
    ..To assess whether statin therapy decreases the incidence of cultures positive for Candida species among high-risk hospitalized patients with type 2 diabetes mellitus (DM)...
  9. Watanabe R, Matsumoto T, Sano G, Ishii Y, Tateda K, Sumiyama Y, et al. Efficacy of bacteriophage therapy against gut-derived sepsis caused by Pseudomonas aeruginosa in mice. Antimicrob Agents Chemother. 2007;51:446-52 pubmed
    ..In conclusion, our findings suggest that oral administration of phage may be effective against gut-derived sepsis caused by P. aeruginosa...

More Information

Publications62

  1. Zuccaro G. Epidemiology of lower gastrointestinal bleeding. Best Pract Res Clin Gastroenterol. 2008;22:225-32 pubmed publisher
    ..Determining the precise impact of colonoscopy on the outcome of lower GI bleeding is difficult due to the retrospective nature of many studies, and the frequent inability to definitively establish the exact bleeding site...
  2. Kumar V, Oscarsson S, Friberg L, Isbister G, Hackett L, Duffull S. The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose. Clin Pharmacol Ther. 2009;86:403-10 pubmed publisher
    ..Both SDAC alone, and a combination of SDAC and WBI, decreased the AUC after venlafaxine overdose, but the combination may be more beneficial because it reduces peak concentrations to a greater extent...
  3. Patel N, Amarapurkar D, Agal S, Baijal R, Kulshrestha P, Pramanik S, et al. Gastrointestinal luminal tuberculosis: establishing the diagnosis. J Gastroenterol Hepatol. 2004;19:1240-6 pubmed
    ..To study the profile of gastrointestinal luminal tuberculosis (GITB) patients who have been treated on a confirmed and a presumptive diagnosis...
  4. Sun Y, Zheng F, Li Y, Wu R, Liu Y, Liu M, et al. Correlation between lower gastrointestinal tract symptoms and quality of life in patients with stable chronic obstructive pulmonary disease. J Tradit Chin Med. 2013;33:608-14 pubmed
    ..To explore correlations between the symptoms of constipation and abdominal distention and severity of chronic obstructive pulmonary disease (COPD) in patients with stable disease...
  5. Bromberg L. Intelligent polyelectrolytes and gels in oral drug delivery. Curr Pharm Biotechnol. 2003;4:339-49 pubmed
  6. Stander N, Wagner W, Goddard A, Kirberger R. Normal canine pediatric gastrointestinal ultrasonography. Vet Radiol Ultrasound. 2010;51:75-8 pubmed
    ..6-2.5 mm), respectively. Homogenous, hypoechoic jejunal lymph nodes were easily found and the mean thickness was 7.1 +/- SD 2.2 mm (range 1.5-12.5 mm). A mild amount of anechoic free peritoneal fluid was present in all puppies...
  7. Aid M, Abbink P, Larocca R, Boyd M, Nityanandam R, Nanayakkara O, et al. Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys. Cell. 2017;169:610-620.e14 pubmed publisher
    ..These data raise the possibility that persistent or occult neurologic and lymphoid disease may occur following clearance of peripheral virus in ZIKV-infected individuals. ..
  8. Dietrich C, Gehrich A, Bakaya S. Surgical exposure and anatomy of the female pelvis. Surg Clin North Am. 2008;88:223-43, v pubmed publisher
    ..This article highlights basic anatomy of the female pelvis and emphasizes points of caution during pelvic surgery, as well as reviews the essential principles of pelvic support...
  9. Duan L, Yan Y, Sun Y, Zhao B, Hu W, Li G. Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions. Int J Pharm. 2013;445:134-40 pubmed publisher
    ..The interaction of capsaicin with P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) was also investigated...
  10. Hernández Rodríguez J, Molloy E, Hoffman G. Single-organ vasculitis. Curr Opin Rheumatol. 2008;20:40-6 pubmed publisher
    ..To recommend a rational approach to diagnosis, longitudinal follow-up and treatment...
  11. Davila R, Rajan E, Adler D, Egan J, Hirota W, Leighton J, et al. ASGE Guideline: the role of endoscopy in the patient with lower-GI bleeding. Gastrointest Endosc. 2005;62:656-60 pubmed
  12. Strate L, Syngal S. Predictors of utilization of early colonoscopy vs. radiography for severe lower intestinal bleeding. Gastrointest Endosc. 2005;61:46-52 pubmed
    ..This study assessed factors associated with early (within 24 hours of presentation) colonoscopy vs. radiographic evaluation of patients with severe acute lower intestinal bleeding in routine practice...
  13. Takami S, Goryo M, Masegi T, Okada K. Systemic spindle-cell proliferative disease in broiler chickens. J Vet Med Sci. 2005;67:13-8 pubmed
  14. Jacobson P, Huang J, Wu J, Kim M, Logan B, Alousi A, et al. Mycophenolate pharmacokinetics and association with response to acute graft-versus-host disease treatment from the Blood and Marrow Transplant Clinical Trials Network. Biol Blood Marrow Transplant. 2010;16:421-9 pubmed publisher
    ..The current practice of MMF 1 gm twice daily dosing provides low plasma concentrations in many patients. Higher doses may improve the efficacy of MMF as aGVHD therapy...
  15. Bogue C, Alzahrani A, Wales P, John P, Amaral J. Delayed, life-threatening lower gastrointestinal hemorrhage in an infant after serial transverse enteroplasty: treatment with transcatheter n-butyl-2-cyanoacrylate embolization. Pediatr Radiol. 2009;39:1098-101 pubmed publisher
    ..To the best of our knowledge this is both the first report of successful glue embolization for LGI bleeding in a child and also the first report of severe hemorrhage after the STEP procedure...
  16. Lee S, Welman C, Ramsay D. Investigation of acute lower gastrointestinal bleeding with 16- and 64-slice multidetector CT. J Med Imaging Radiat Oncol. 2009;53:56-63 pubmed publisher
    ..the usefulness of 16- and 64-slice multidetector CT (MDCT) in the detection of a bleeding site in acute lower gastrointestinal tract (GIT) haemorrhage by conducting a retrospective study of cases of presumed acute lower GIT haemorrhage ..
  17. Rios A, Montoya M, Rodriguez J, Serrano A, Molina J, Parrilla P. Acute lower gastrointestinal hemorrhages in geriatric patients. Dig Dis Sci. 2005;50:898-904 pubmed
    ..045). Acute LGIH in geriatric patients relents in most cases with the use of conservative measures, although there is a high percentage of related morbidity and mortality, and of relapse of bleeding...
  18. Yi W, Garg G, Sava J. Localization and definitive control of lower gastrointestinal bleeding with angiography and embolization. Am Surg. 2013;79:375-80 pubmed
    ..7 per cent of patients. Definitive hemostasis through embolization was successful in only 8.6 per cent of patients who underwent angiography for lower gastrointestinal bleeding...
  19. Lurie Y, Bentur Y, Levy Y, Baum E, Krivoy N. Limited efficacy of gastrointestinal decontamination in severe slow-release carbamazepine overdose. Ann Pharmacother. 2007;41:1539-43 pubmed
    ..To report the limited efficacy of both multiple doses of activated charcoal (MDAC) and whole bowel irrigation (WBI) in a patient with severe overdose of slow-release carbamazepine...
  20. Bosmans J, Moossdorff M, Al Taher M, van Beek L, Derikx J, Bouvy N. International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract. Int J Colorectal Dis. 2016;31:1021-1030 pubmed publisher
    ..consensus on the most appropriate animal models and outcome measures in research on anastomoses in the lower gastrointestinal tract (GIT)...
  21. Antonescu C. Gastrointestinal stromal tumor (GIST) pathogenesis, familial GIST, and animal models. Semin Diagn Pathol. 2006;23:63-9 pubmed
    ..This is a US government work. There are no restrictions on its use...
  22. Sheridan J, Hunt G, Maclennan A. Ultrasound diagnosis of clinically undetected Clostridium difficile toxin colitis. Clin Radiol. 2006;61:902 pubmed
  23. Prakash S, Tomaro Duchesneau C, Saha S, Cantor A. The gut microbiota and human health with an emphasis on the use of microencapsulated bacterial cells. J Biomed Biotechnol. 2011;2011:981214 pubmed publisher
    ..This paper focuses on probiotic modulation of the gut microbiota by their delivery to the lower gastrointestinal tract (GIT). There are numerous obstacles to overcome before microorganisms can be utilized as therapeutics...
  24. Mariani G, Pauwels E, AlSharif A, Marchi S, Boni G, Barreca M, et al. Radionuclide evaluation of the lower gastrointestinal tract. J Nucl Med. 2008;49:776-87 pubmed publisher
    ..diagnostic performance parameters of nuclear medicine procedures used on patients with disorders of the lower gastrointestinal tract, with the exclusion of techniques using tumor-seeking radiopharmaceuticals...
  25. Grandi D, Shenton F, Chazot P, Morini G. Immunolocalization of histamine H3 receptors on endocrine cells in the rat gastrointestinal tract. Histol Histopathol. 2008;23:789-98 pubmed publisher
    ..Location, the influence of food deprivation and colocalization with histidine decarboxylase indicate that H3R positive cells correspond to the enterochromaffin-like cells (ECL)...
  26. Wong N, Herriot M, Rae F. An immunohistochemical study and review of potential markers of human intestinal M cells. Eur J Histochem. 2003;47:143-50 pubmed
    ..None of the other 7 markers studied is exclusively expressed by human M cells...
  27. Ontsouka E, Blum J, Steiner A, Meylan M. mRNA expression and binding sites for alpha2-adrenergic receptor subtypes in muscle layers of the ileum and spiral colon of dairy cows. Am J Vet Res. 2006;67:1883-9 pubmed
    ..To measure maximum binding capacity (B(max)) and levels of mRNA expression for alpha(2)-adrenergic receptor (AR) subtypes in ileal and colonic muscle layers of healthy dairy cows...
  28. Srygley F, Gerardo C, Tran T, Fisher D. Does this patient have a severe upper gastrointestinal bleed?. JAMA. 2012;307:1072-9 pubmed publisher
    ..Emergency physicians must determine both the location and the severity of acute gastrointestinal bleeding (GIB) to optimize the diagnostic and therapeutic approaches...
  29. Diehl S, Ko H, Dominguez E, Kaare Tesdal I, Kahler G, Bohm C, et al. [Negative endoscopy and MSCT findings in patients with acute lower gastrointestinal hemorrhage. Value of (99m)Tc erythrocyte scintigraphy]. Radiologe. 2007;47:64-70 pubmed
    ..To evaluate the clinical use of (99m)Tc red blood cell imaging (RBC imaging) in patients presenting with acute lower gastrointestinal (GI) bleeding and negative endoscopy and multislice computed tomography (MSCT) findings...
  30. Tuğcu Demiröz F, Acartürk F, Takka S, Konuş Boyunağa O. In-vitro and in-vivo evaluation of mesalazine-guar gum matrix tablets for colonic drug delivery. J Drug Target. 2004;12:105-12 pubmed
    ..Barium sulphate was used as a marker in the tablets for in vivo studies. These results showed that, the matrix tablets reached the colon; not being subjected to disintegration in the upper region of the GI system in all the subjects...
  31. Strate L, Saltzman J, Ookubo R, Mutinga M, Syngal S. Validation of a clinical prediction rule for severe acute lower intestinal bleeding. Am J Gastroenterol. 2005;100:1821-7 pubmed
    ..We previously retrospectively identified predictors of severity in patients with acute lower intestinal bleeding. The aim of this study was to prospectively validate a clinical prediction rule for severe acute lower intestinal bleeding...
  32. Kim C, Suhocki P, Miller M, Khan M, Janus G, Smith T. Provocative mesenteric angiography for lower gastrointestinal hemorrhage: results from a single-institution study. J Vasc Interv Radiol. 2010;21:477-83 pubmed publisher
    ..To determine the diagnostic capability, complication rate, and potential predictors of success for provocative mesenteric angiography in patients with obscure and recurrent lower gastrointestinal (GI) hemorrhage...
  33. Ho G. Lower gastrointestinal distress in endurance athletes. Curr Sports Med Rep. 2009;8:85-91 pubmed publisher
    ..The sports medicine clinician should be familiar with the management of these problems in order to optimize treatment, facilitate return to play, and maximize the athlete's potential...
  34. Shinmyo Y, Mito T, Uda T, Nakamura T, Miyawaki K, Ohuchi H, et al. brachyenteron is necessary for morphogenesis of the posterior gut but not for anteroposterior axial elongation from the posterior growth zone in the intermediate-germband cricket Gryllus bimaculatus. Development. 2006;133:4539-47 pubmed
  35. Bounds B, Kelsey P. Lower gastrointestinal bleeding. Gastrointest Endosc Clin N Am. 2007;17:273-88, vi pubmed
    ..Lower endoscopic evaluation is established as the diagnostic procedure of choice in the setting of acute lower GI hemorrhage...
  36. Geboes K, Ectors N, Geboes K. Pathology of early lower GI cancer. Best Pract Res Clin Gastroenterol. 2005;19:963-78 pubmed
    ..Whenever a favourable tumour grade is found, without vascular invasion and tumour budding, there seems to be a low risk for adverse outcome and laparotomy may thus be avoided...
  37. Fox J, Ge Z, Whary M, Erdman S, Horwitz B. Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011;4:22-30 pubmed publisher
    ..hepaticus pathogenesis. Delineating targets of H. hepaticus virulence factors could facilitate novel approaches to treating microbially induced lower bowel inflammatory diseases...
  38. Laverty G, Elbrønd V, Arnason S, Skadhauge E. Endocrine regulation of ion transport in the avian lower intestine. Gen Comp Endocrinol. 2006;147:70-7 pubmed
    ..Recent findings suggesting effects of other hormones on lower intestinal transport are also presented...
  39. Zink S, Ohki S, Stein B, Zambuto D, Rosenberg R, Choi J, et al. Noninvasive evaluation of active lower gastrointestinal bleeding: comparison between contrast-enhanced MDCT and 99mTc-labeled RBC scintigraphy. AJR Am J Roentgenol. 2008;191:1107-14 pubmed publisher
    ..The purpose of our study was to compare contrast-enhanced MDCT and (99m)Tc-labeled RBC scanning for the evaluation of active lower gastrointestinal bleeding...
  40. Padia S, Bybel B, Newman J. Radiologic diagnosis and management of acute lower gastrointestinal bleeding. Cleve Clin J Med. 2007;74:417-20 pubmed
    ..In patients with acute lower gastrointestinal bleeding, colonoscopy is the initial test of choice. But when colonoscopy gives indeterminate results or cannot be performed, either radionuclide imaging or angiography is indicated...
  41. Currie G. Cost-effectiveness analysis of subtraction scintigraphy in patients with acute lower gastrointestinal tract hemorrhage. J Nucl Med Technol. 2007;35:140-7 pubmed
    ..Subtraction scintigraphy has been used in the evaluation of acute lower gastrointestinal tract hemorrhage (LGIH) to reduce the impact of interpretive confounders...
  42. Yunos A, Jaafar H, Idris F, Kaur G, Mabruk M. Detection of Epstein-Barr virus in lower gastrointestinal tract lymphomas: a study in Malaysian patients. Mol Diagn Ther. 2006;10:251-6 pubmed
    ..However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (GI) tract has not been fully elucidated...
  43. Guenther T, Roessner A. Pathology of the lower gastrointestinal tract--research and practice. Pathol Res Pract. 2008;204:429-30 pubmed publisher
  44. Frodsham A, Berkmen T, Ananian C, Fung A. Initial experience using N-butyl cyanoacrylate for embolization of lower gastrointestinal hemorrhage. J Vasc Interv Radiol. 2009;20:1312-9 pubmed publisher
    ..To report initial experience using N-butyl cyanoacrylate (n-BCA) to control lower gastrointestinal hemorrhage (LGIH)...
  45. Brouns M, de Castro S, Terwindt Rouwenhorst E, Massa V, Hekking J, Hirst C, et al. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse. Hum Mol Genet. 2011;20:1536-46 pubmed publisher
    ..Overall, our data suggest that defects in Axd mutant embryos result from over-expression of Grhl2...
  46. Zia N, Hussain T, Salamat A, Mirza S, Hassan F, Waqar A. Diagnostic evaluation of patients presenting with bleeding per rectum by colonoscopy. J Ayub Med Coll Abbottabad. 2008;20:73-6 pubmed
    ..This study validated the previous findings. The Objective of this study was to determine the causes of rectal bleeding in adult patients at Military Hospital, Rawalpindi...
  47. Sabharwal R, Vladica P, Chou R, Law W. Helical CT in the diagnosis of acute lower gastrointestinal haemorrhage. Eur J Radiol. 2006;58:273-9 pubmed
    A pilot study to evaluate helical computer tomography (CT) as a diagnostic tool for acute lower gastrointestinal tract (GIT) bleeding...
  48. Bharucha A. Lower gastrointestinal functions. Neurogastroenterol Motil. 2008;20 Suppl 1:103-13 pubmed publisher
    ..This article is a broad perspective of the current status and a personal perspective of future challenges in understanding lower gastrointestinal functions in health and disease in humans...
  49. Chojnacki C, Wisniewska Jarosinska M, Walecka Kapica E, Klupinska G, Jaworek J, Chojnacki J. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J Physiol Pharmacol. 2011;62:327-34 pubmed
    ..The results of the study allowed drawing the conclusion that adjuvant melatonin therapy may help in sustaining remission in patients with UC...
  50. Sakorafas G, Tsolakides G, Grigoriades K, Bakoyiannis C, Peros G. Colonic mucormycosis: an exceptionally rare cause of massive lower gastrointestinal bleeding. Dig Liver Dis. 2006;38:616-7 pubmed
  51. Xie B, Xiao S, Zhu S, Wang G, Lv K, Li H, et al. Risk factors and prognosis of lower digestive tract haemorrhage in severe burns: a 12-year retrospective analysis. Burns. 2011;37:328-32 pubmed publisher
    ..To explore the risk factors relating to lower digestive tract haemorrhage in severe burns and summarise the experience in clinical diagnosis and treatment...
  52. Ruiz Sanchez E, Lange A, Orchard I. Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles. Toxicon. 2010;56:1043-51 pubmed publisher
  53. Stander N, Wagner W, Goddard A, Kirberger R. Ultrasonographic appearance of canine parvoviral enteritis in puppies. Vet Radiol Ultrasound. 2010;51:69-74 pubmed
    ..The jejunal lymph node size was within normal limits. None of the above changes are pathognomonic for canine parvoviral enteritis but finding them in combination is highly suggestive...