colon

Summary

Summary: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.

Top Publications

  1. van Zanten G, Knudsen A, Röytiö H, Forssten S, Lawther M, Blennow A, et al. The effect of selected synbiotics on microbial composition and short-chain fatty acid production in a model system of the human colon. PLoS ONE. 2012;7:e47212 pubmed publisher
    ..the composition and activity of human fecal microbiota using a four-stage semicontinuous model system of the human colon. Carbohydrates were selected by their ability to enhance growth of the probiotic bacteria Lactobacillus ..
  2. Kirchberger S, Royston D, Boulard O, Thornton E, Franchini F, Szabady R, et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med. 2013;210:917-31 pubmed
    Patients with inflammatory bowel disease (IBD) have an increased risk of colon cancer. However, the immune cells and cytokines that mediate the transition from intestinal inflammation to cancer are poorly understood...
  3. Fordham R, Yui S, Hannan N, Soendergaard C, Madgwick A, Schweiger P, et al. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell. 2013;13:734-44 pubmed publisher
    ..This work provides insight into mechanisms underlying development of the mammalian intestine and points to future opportunities for patient-specific regeneration of the digestive tract. ..
  4. Zavaleta C, Garai E, Liu J, Sensarn S, Mandella M, Van de Sompel D, et al. A Raman-based endoscopic strategy for multiplexed molecular imaging. Proc Natl Acad Sci U S A. 2013;110:E2288-97 pubmed publisher
    ..It has played a key role in screening colon cancer and is credited with preventing deaths through the detection and removal of precancerous polyps...
  5. Wu R, Pasyk M, Wang B, Forsythe P, Bienenstock J, Mao Y, et al. Spatiotemporal maps reveal regional differences in the effects on gut motility for Lactobacillus reuteri and rhamnosus strains. Neurogastroenterol Motil. 2013;25:e205-14 pubmed publisher
    ..Intraluminal peak pressure (PPr) was measured and video recordings made of mouse ex vivo jejunum and colon segments before and after intraluminal applications of Lactobacillus rhamnosus (JB-1) or Lactobacillus reuteri (..
  6. Garib R, Garla P, Torrinhas R, Bertevello P, Logullo A, Waitzberg D. Effects of parenteral fish oil lipid emulsions on colon morphology and cytokine expression after experimental colitis. Nutr Hosp. 2013;28:849-56 pubmed publisher
    ..There was a direct and inverse relation of colon interleukin (IL)-1 and IL-4 respectively, with histological necrosis...
  7. Akagi R, Ohno M, Matsubara K, Fujimoto M, Nakai A, Inouye S. Glutamine protects intestinal barrier function of colon epithelial cells from ethanol by modulating Hsp70 expression. Pharmacology. 2013;91:104-11 pubmed publisher
    ..Taken together, these observations indicate that glutamine protects the intestinal barrier function in Caco-2 cells, in part by modulating HSF1-mediated Hsp70 expression. ..
  8. Chen X, Zhai X, Shi J, Liu W, Tao H, Sun X, et al. Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production. Dig Dis Sci. 2013;58:1560-8 pubmed publisher
    ..Orally administered lactulose, a potent H2 inducer, is digested by colon microflora and significantly increases H2 production, indicating its potential anti-inflammatory action...
  9. Wichmann A, Allahyar A, Greiner T, Plovier H, Lundén G, Larsson T, et al. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe. 2013;14:582-90 pubmed publisher
    ..availability through the fermentation of dietary fiber and production of short-chain fatty acids (SCFAs) in the colon. SCFAs are proposed to stimulate secretion of the proglucagon (Gcg)-derived incretin hormone GLP-1, which ..

More Information

Publications81

  1. González Vallinas M, Molina S, Vicente G, de la Cueva A, Vargas T, Santoyo S, et al. Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacol Res. 2013;72:61-8 pubmed publisher
    ..fluid rosemary extract (SFRE), alone and in combination with 5-FU, as a potential adjuvant therapy useful for colon cancer patients...
  2. Khan R, Khan A, Lateef A, Rehman M, Tahir M, Ali F, et al. Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats. PLoS ONE. 2013;8:e56020 pubmed publisher
    b>Colon carcinogenesis is a multistep process and it emanates from a series of molecular and histopathological alterations. Glycyrrhizic acid (GA) is a natural and major pentacyclic triterpenoid glycoside of licorice roots extracts...
  3. Randhawa H, Kibble K, Zeng H, Moyer M, Reindl K. Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicol In Vitro. 2013;27:1626-33 pubmed publisher
    ..compound isolated from long peppers that shows selective toxicity towards a variety of cancer cell types including colon cancer...
  4. Lee K, Ho J, Akmal Y, Nelson R, Pigazzi A. Short- and long-term outcomes of intracorporeal versus extracorporeal ileocolic anastomosis in laparoscopic right hemicolectomy for colon cancer. Surg Endosc. 2013;27:1986-90 pubmed publisher
    ..short- and long-term outcomes of intracorporeal ileocolic anastomosis (IA) in laparoscopic right hemicolectomy for colon cancer compared with extracorporeal anastomosis (EA)...
  5. Das S, Czarnek M, Bzowska M, Mezyk Kopec R, Stalinska K, Wyroba B, et al. ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. PLoS ONE. 2012;7:e50791 pubmed publisher
    ..Here we show, using MC38CEA murine colon carcinoma model, that ADAM17 also regulates tumor angiogenesis and cytokine profile...
  6. Choy Y, Jaggers G, Oteiza P, Waterhouse A. Bioavailability of intact proanthocyanidins in the rat colon after ingestion of grape seed extract. J Agric Food Chem. 2013;61:121-7 pubmed publisher
    ..absorbed in the small intestine, but the metabolism of oligomeric and polymeric proanthocyanidins (PAC) in the colon is poorly understood...
  7. Burliński P. Inflammation- and axotomy-induced changes in cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) nervous structures in the porcine descending colon. Pol J Vet Sci. 2012;15:517-24 pubmed
    This study reports on changes in CART-like immunoreactive (CART-LI) nerve structures in the porcine descending colon during chemically driven inflammation and after axotomy...
  8. Johansson M, Gustafsson J, Holmén Larsson J, Jabbar K, Xia L, Xu H, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut. 2014;63:281-91 pubmed publisher
    The inner mucus layer in mouse colon normally separates bacteria from the epithelium...
  9. Huber S, Gagliani N, Zenewicz L, Huber F, Bosurgi L, Hu B, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012;491:259-63 pubmed publisher
    ..we describe that IL-22BP has a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon. IL-22BP is highly expressed by dendritic cells in the colon in steady-state conditions...
  10. Bernard J, McCann S, Bhardwaj V, Washington M, Frey M. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. J Biol Chem. 2012;287:39850-8 pubmed publisher
    ..Thus, exogenous NRG4 may be beneficial for disorders in which epithelial apoptosis is part of the pathology. ..
  11. Ferraro A, Mourtzoukou D, Kosmidou V, Avlonitis S, Kontogeorgos G, Zografos G, et al. EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells. Int J Biochem Cell Biol. 2013;45:243-54 pubmed publisher
    ..Herein, we provide evidence supporting the idea that oncogenic Epithelial-Mesenchymal Transition in colon cancer cell models is partially controlled by epigenetic factors such as the transcription regulator EZH2...
  12. Turpin W, Humblot C, Noordine M, Wrzosek L, Tomas J, Mayeur C, et al. Behavior of lactobacilli isolated from fermented slurry (ben-saalga) in gnotobiotic rats. PLoS ONE. 2013;8:e57711 pubmed publisher
    ..Furthermore, the global morphology of the colon epithelium was not disturbed by the BSL cocktail...
  13. Li Y, Kokrashvili Z, Mosinger B, Margolskee R. Gustducin couples fatty acid receptors to GLP-1 release in colon. Am J Physiol Endocrinol Metab. 2013;304:E651-60 pubmed publisher
    ..Gustducin has also been found in colon, although its function there is unclear...
  14. Khare V, Lang M, Dammann K, Campregher C, Lyakhovich A, Gasche C. Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells. Biochem Pharmacol. 2014;87:312-20 pubmed publisher
    ..Induction of membranous expression of E-cadherin by 5-ASA is a novel mechanism for mucosal healing in colitis that might impede tumor progression by modulation of GnT-III expression. ..
  15. Yamaki M, Shinozaki K, Sakaguchi T, Meseck M, Ebert O, Ohdan H, et al. The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer. Int J Mol Med. 2013;31:299-306 pubmed publisher
    ..001), none of the rats achieved long-term survival. VSV virotherapy has potential for CRC liver and lung metastases, although systemic venous delivery is much less effective than locoregional delivery such as hepatic arterial infusion...
  16. El Salhy M, Gundersen D, Hatlebakk J, Hausken T. High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. World J Gastroenterol. 2012;18:6070-5 pubmed publisher
    ..To investigate colonic endocrine cells in lymphocytic colitis (LC) patients...
  17. Wen X, Wang C, Yu C, Zhang Z, Calway T, Wang Y, et al. Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis. Am J Chin Med. 2013;41:1097-108 pubmed publisher
    ..DSS-induced colitis was scored with the disease activity index (DAI). Body weight and colon length were also measured...
  18. Mirpuri J, Sotnikov I, Myers L, Denning T, Yarovinsky F, Parkos C, et al. Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. PLoS ONE. 2012;7:e51955 pubmed publisher
    ..regulation of MIP-2, TNF-?, IL-12, IL-10 and the IL-10R2 subunit of the IL-10 receptor in immature murine colon, while the expression of IL-6 and IL-18 was independent of postnatal age...
  19. Callari M, Dugo M, Musella V, Marchesi E, Chiorino G, Grand M, et al. Comparison of microarray platforms for measuring differential microRNA expression in paired normal/cancer colon tissues. PLoS ONE. 2012;7:e45105 pubmed publisher
    ..miRNA analysis methods have only recently been systematically compared but only in few cases using clinical samples...
  20. Kapitanovic S, Cacev T, Loncar B, Catela Ivkovic T, Krizanac S, Pavelic K. Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma. Exp Mol Pathol. 2014;96:92-7 pubmed publisher
    ..The aim of this study was to examine the frequency of FHIT gene LOH as well as FHIT mRNA and protein expression in sporadic colon adenocarcinoma.
  21. Wang N, Du X, Zang L, Song N, Yang T, Dong R, et al. Prognostic impact of Metadherin-SND1 interaction in colon cancer. Mol Biol Rep. 2012;39:10497-504 pubmed publisher
    ..However, its roles in colon cancer are still unclear. To investigate the clinical value of MTDH and SND1 expression in colon cancer...
  22. Hsu F, Yu D, Huang C. Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery. J Mater Sci Mater Med. 2013;24:317-23 pubmed publisher
    ..and evaluate calcium pectinate/alginate microspheres (PAMs) and to exploit their pH-sensitive properties for colon-targeted delivery of encapsulated cisplatin. PAMs were prepared using an electrospraying method...
  23. Sadik N, Shaker O. Dietary folate suppresses DMH-induced colon carcinogenesis in a rat model and affects DMH-induced expression of four DNA repair enzymes. Nutr Cancer. 2012;64:1196-203 pubmed publisher
    This study investigated the potential role of folate in the dimethylhydrazine (DMH) colon cancer model in male Wistar rats...
  24. IJssennagger N, Derrien M, van Doorn G, Rijnierse A, van den Bogert B, Muller M, et al. Dietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk. PLoS ONE. 2012;7:e49868 pubmed publisher
    b>Colon cancer is a major cause of cancer deaths in Western countries and is associated with diets high in red meat...
  25. Tsukamoto H, Tanida S, Ozeki K, Ebi M, Mizoshita T, Shimura T, et al. Annexin A2 regulates a disintegrin and metalloproteinase 17-mediated ectodomain shedding of pro-tumor necrosis factor-? in monocytes and colon epithelial cells. Inflamm Bowel Dis. 2013;19:1365-73 pubmed publisher
    ..ANX A2 was closely associated with ADAM17 and played an important role in TNF-? shedding by TPA. Inhibition of ANX A2 might be a new therapeutic strategy for prevention of TNF-? shedding during inflammatory bowel disease inflammation. ..
  26. Ermund A, Schütte A, Johansson M, Gustafsson J, Hansson G. Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches. Am J Physiol Gastrointest Liver Physiol. 2013;305:G341-7 pubmed publisher
    b>Colon has been shown to have a two-layered mucus system where the inner layer is devoid of bacteria. However, a complete overview of the mouse gastrointestinal mucus system is lacking...
  27. Mansoor S, Dolkar T, El Fanek H. Polyps and polypoid lesions of the colon. Int J Surg Pathol. 2013;21:215-23 pubmed publisher
    ..A significant portion of colorectal biopsies are performed for evaluation of polyps or polypoid lesions. Accurately identifying these lesions will promote better patient care...
  28. Malekian V, Amirfattahi R, Sadri S, Mokhtari M, Aghaie A, Rezaeian M. Computer aided measurement of sub-epithelial collagen band in colon biopsies for collagenous colitis diagnosis. Micron. 2013;45:59-67 pubmed publisher
    ..standard for a confirmative diagnosis of CC is to measure the thickness of the sub-epithelial collagen (SEC) in colon tissue samples...
  29. Vemula S, Veerareddy P. Development, evaluation and pharmacokinetics of time-dependent ketorolac tromethamine tablets. Expert Opin Drug Deliv. 2013;10:33-45 pubmed publisher
    The present study was intended to develop a time-dependent colon-targeted compression-coated tablets of ketorolac tromethamine (KTM) using hydroxypropyl methylcellulose (HPMC) that release the drug slowly but completely in the colonic ..
  30. Hamiza O, Rehman M, Tahir M, Khan R, Khan A, Lateef A, et al. Amelioration of 1,2 Dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats. Asian Pac J Cancer Prev. 2012;13:4393-402 pubmed
    b>Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries...
  31. Zimmerman M, Homanics G, Lazo J. Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. PLoS ONE. 2013;8:e58300 pubmed publisher
    ..is normally associated with late-stage cancer and metastasis, we observed increased Ptp4a3 expression in the colon of wildtype mice immediately following treatment with the carcinogen azoxymethane...
  32. Schaafsma B, Verbeek F, van der Vorst J, Hutteman M, Kuppen P, Frangioni J, et al. Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging. J Surg Res. 2013;183:253-7 pubmed publisher
    The sentinel lymph node procedure has been proposed to improve nodal staging in colon cancer patients...
  33. Carbone S, Dinning P, Costa M, Spencer N, Brookes S, Wattchow D. Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon. Neurogastroenterol Motil. 2013;25:670-6 pubmed publisher
    ..The aim of this study was to determine if ascending excitatory interneuronal pathways can modulate spontaneous phasic contractions in isolated preparations of human colonic circular muscle...
  34. Koukos G, Polytarchou C, Kaplan J, Morley Fletcher A, Gras Miralles B, Kokkotou E, et al. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology. 2013;145:842-52.e2 pubmed publisher
    ..We investigated whether colonic mucosal miRs are altered in children with ulcerative colitis (UC)...
  35. Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher
    ..Here, we show in human colon cancer cells that dietary isothiocyanates (ITCs) inhibit HDAC activity and increase HDAC protein turnover with the ..
  36. Wright Jin E, Grider J, Duester G, Heuckeroth R. Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function. Dev Biol. 2013;381:28-37 pubmed publisher
    ..We found that Raldh1-/-, Raldh2+/-, Raldh3+/- (R1(KO)R2(Het)R3(Het)) mutant mice had a reduced colon myenteric neuron density, reduced colon myenteric neuron to glia ratio, reduced colon submucosal neuron density, ..
  37. Broadhurst M, Ardeshir A, Kanwar B, Mirpuri J, Gundra U, Leung J, et al. Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog. 2012;8:e1003000 pubmed publisher
    ..These results also define ICD in monkeys as a tractable preclinical model for ulcerative colitis in which these effects can be further investigated...
  38. Huynh D, Akcora D, Malaterre J, Chan C, Dai X, Bertoncello I, et al. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. PLoS ONE. 2013;8:e56951 pubmed publisher
    ..Both Csf1r(-/-) and Csf1(op/op) mice were found to have colon defects in enterocytes and enteroendocrine cell fate, with excessive goblet cell staining and reduced cell ..
  39. Knapp B, Bauer L, Swanson K, Tappenden K, Fahey G, de Godoy M. Soluble fiber dextrin and soluble corn fiber supplementation modify indices of health in cecum and colon of Sprague-Dawley rats. Nutrients. 2013;5:396-410 pubmed publisher
    ..health outcomes resulting from dietary supplementation of novel, low-digestible carbohydrates in the cecum and colon of Sprague-Dawley rats randomly assigned to one of four treatment groups for 21 days: 5% cellulose (Control), ..
  40. Li D, Sun X, Yan D, Huang J, Luo Q, Tang H, et al. Piwil2 modulates the proliferation and metastasis of colon cancer via regulation of matrix metallopeptidase 9 transcriptional activity. Exp Biol Med (Maywood). 2012;237:1231-40 pubmed publisher
    ..However, the role of Piwil2 in colon cancer remains poorly understood...
  41. Kallenbach Thieltges A, Großerüschkamp F, Mosig A, Diem M, Tannapfel A, Gerwert K. Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections. J Biophotonics. 2013;6:88-100 pubmed publisher
    ..we report a comparison of immunohistochemical (IHC), histopathological and spectral histopathological results for colon cancer tissue sections...
  42. Morales C, Rachidi S, Hong F, Sun S, Ouyang X, Wallace C, et al. Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res. 2014;74:446-59 pubmed publisher
    Macrophages are important drivers in the development of inflammation-associated colon cancers, but the mechanistic underpinnings for their contributions are not fully understood...
  43. Lacombe A, Li R, Klimis Zacas D, Kristo A, Tadepalli S, Krauss E, et al. Lowbush wild blueberries have the potential to modify gut microbiota and xenobiotic metabolism in the rat colon. PLoS ONE. 2013;8:e67497 pubmed publisher
    ..the present study, dietary enrichment of lowbush wild blueberries (LWB) was examined to determine their effect on colon microbial composition and their potential in promoting gut health...
  44. Prorok Hamon M, Friswell M, Alswied A, Roberts C, Song F, Flanagan P, et al. Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer. Gut. 2014;63:761-70 pubmed publisher
    ..We investigated genes responsible for these effects and their co-association in colonic mucosal isolates...
  45. Ou J, Carbonero F, Zoetendal E, Delany J, Wang M, Newton K, et al. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. Am J Clin Nutr. 2013;98:111-20 pubmed publisher
    Epidemiologic studies have suggested that most cases of sporadic colon cancer can be attributed to diet...
  46. Kasprzak A, Szaflarski W, Szmeja J, Andrzejewska M, Przybyszewska W, Kaczmarek E, et al. Differential expression of IGF-1 mRNA isoforms in colorectal carcinoma and normal colon tissue. Int J Oncol. 2013;42:305-16 pubmed publisher
    ..expression of the total IGF-1 mRNA and all splicing isoforms of IGF-1 mRNA decreased as compared to the normal colon tissues, although however, with conservation of both gene promoter activities and with the continued principal ..
  47. Javed S, Mejías Luque R, Kalali B, Bolz C, Gerhard M. Helicobacter bilis gamma-glutamyltranspeptidase enhances inflammatory stress response via oxidative stress in colon epithelial cells. PLoS ONE. 2013;8:e73160 pubmed publisher
    ..bilis infected colon cancer cells...
  48. Puangpraphant S, Dia V, de Mejia E, Garcia G, Berhow M, Wallig M. Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-?B p65ser(311) signaling via I?B-? and GSK-3? reduced phosphorylation. Biofactors. 2013;39:430-40 pubmed publisher
    ..7% and 24.4%, respectively (P < 0.05). Results suggest the mechanism involved in the chemopreventive effect of YMT and mate saponin consumption in AOM induced-colonic inflammation in rats is through inhibition of NF-?B...
  49. Dejea C, Wick E, Sears C. Bacterial oncogenesis in the colon. Future Microbiol. 2013;8:445-60 pubmed publisher
    The human colon plays host to a diverse and metabolically complex community of microorganisms...
  50. Wen Y, Stevens P, Gasser M, Andrei R, Gao T. Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. Mol Cell Biol. 2013;33:4594-605 pubmed publisher
    ..PHLPP, a novel family of Ser/Thr protein phosphatases, functions as a tumor suppressor in colon cancers...
  51. van den Broek C, Bastiaannet E, Dekker J, Portielje J, de Craen A, Elferink M, et al. Time trends in chemotherapy (administration and costs) and relative survival in stage III colon cancer patients - a large population-based study from 1990 to 2008. Acta Oncol. 2013;52:941-9 pubmed publisher
    Use of adjuvant chemotherapy for stage III colon cancer has increased since several trials have shown the beneficial effect on survival...
  52. del Campo M, Toledo H, Lagos N. Okadaic acid toxin at sublethal dose produced cell proliferation in gastric and colon epithelial cell lines. Mar Drugs. 2013;11:4751-60 pubmed publisher
    The aim of this study was to analyze the effect of Okadaic Acid (OA) on the proliferation of gastric and colon epithelial cells, the main target tissues of the toxin...
  53. Jo H, Kim N, Nam R, Kang J, Kim J, Choe G, et al. Fat deposition in the tunica muscularis and decrease of interstitial cells of Cajal and nNOS-positive neuronal cells in the aged rat colon. Am J Physiol Gastrointest Liver Physiol. 2014;306:G659-69 pubmed publisher
    Little is known about the time course of aging on interstitial cells of Cajal (ICC) of colon. The aim of this study was to investigate the change of morphology, ICC, and neuronal nitric oxide synthase (nNOS)-immunoreactive cells in the ..
  54. Bahar B, O Doherty J, Hayes M, Sweeney T. Extracts of brown seaweeds can attenuate the bacterial lipopolysaccharide-induced pro-inflammatory response in the porcine colon ex vivo. J Anim Sci. 2012;90 Suppl 4:46-8 pubmed publisher
    ..effects of extracts of brown seaweed (Ascophyllum nodosum and Fucus serratus) were evaluated on the porcine colon using a bacterial lipopolysaccharide (LPS) ex vivo model. Approximately 1.5 × 1...
  55. Peerless Y, Simon E, Sabo E, Ben Izhak O, Hershkovitz D. Normal colon tissue and colon carcinoma show no difference in heparanase promoter methylation. Exp Mol Pathol. 2013;94:309-13 pubmed publisher
    ..In colon carcinoma, heparanase shows increased expression in tumor compared to normal tissue and its expression correlates ..
  56. McGlynn A, Wasson G, O Reilly S, McNulty H, Downes C, Chang C, et al. Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum. J Nutr. 2013;143:27-33 pubmed publisher
    Low folate status is a risk factor for colon carcinogenesis; mechanisms proposed to account for this relationship include uracil misincorporation into DNA and global DNA hypomethylation...
  57. Chen K, Liu M, Liu Y, Yoshimura T, Shen W, Le Y, et al. Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis. J Clin Invest. 2013;123:1694-704 pubmed
    ..These results indicate that FPR2 is critical in mediating homeostasis, inflammation, and epithelial repair processes in the colon.
  58. Zhou X, Kong X, Yang X, Yin Y. Soybean oligosaccharides alter colon short-chain fatty acid production and microbial population in vitro. J Anim Sci. 2012;90 Suppl 4:37-9 pubmed publisher
    ..Digesta collected from the colon of Huanjiang mini-pigs was used as inoculums, and SBOS (0...
  59. Voloshanenko O, Erdmann G, Dubash T, Augustin I, Metzig M, Moffa G, et al. Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun. 2013;4:2610 pubmed publisher
    ..has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or ?-catenin...
  60. Triff K, Konganti K, Gaddis S, Zhou B, Ivanov I, Chapkin R. Genome-wide analysis of the rat colon reveals proximal-distal differences in histone modifications and proto-oncogene expression. Physiol Genomics. 2013;45:1229-43 pubmed publisher
    ..we assessed the chromatin structure associated with gene expression profiles in the rat proximal and distal colon by globally correlating chromatin immunoprecipitation next-generation sequencing analysis (ChIP-Seq) with mRNA ..
  61. Motta J, Bermúdez Humarán L, Deraison C, Martin L, Rolland C, Rousset P, et al. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med. 2012;4:158ra144 pubmed publisher
    ..This defect is associated with increased elastolytic activity (elastase-like proteolysis) in colon tissue...
  62. Lee W, Kang M, Baek J, Lee J, Ha S. Clinical impact of tumor-infiltrating lymphocytes for survival in curatively resected stage IV colon cancer with isolated liver or lung metastasis. Ann Surg Oncol. 2013;20:697-702 pubmed publisher
    ..However, prognostic significance of tumor-infiltrating lymphocytes (TILs) in curatively resected stage IV colon cancer with isolated liver or lung lesion has not been clarified...
  63. Said H. Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas. Am J Physiol Gastrointest Liver Physiol. 2013;305:G601-10 pubmed publisher
    ..However, recent studies utilizing a variety of human and animal colon preparations clearly demonstrate that such systems do exist in the large intestine...
  64. Hawinkels L, Paauwe M, Verspaget H, Wiercinska E, Van der Zon J, Van der Ploeg K, et al. Interaction with colon cancer cells hyperactivates TGF-? signaling in cancer-associated fibroblasts. Oncogene. 2014;33:97-107 pubmed publisher
    ..In turn this leads to cumulative production of TGF-? and proteinases within the tumor microenvironment, creating a cancer-promoting feedback loop. ..
  65. Hasson R, Briggs A, Carothers A, Davids J, Wang J, Javid S, et al. Estrogen receptor ? or ? loss in the colon of Min/+ mice promotes crypt expansion and impairs TGF? and HNF3? signaling. Carcinogenesis. 2014;35:96-102 pubmed publisher
    ..Here, we extended our results with further comparisons of colon and small intestine from intact female Apc (+/+) (WT), Min/+ and ER-deficient Min/+ mice...
  66. Scheinman E, Rostoker R, LeRoith D. Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways. Mol Cell Endocrinol. 2013;374:101-7 pubmed publisher
    ..Here we tested the effect of cholesterol on MC-38 colon cancer cells...
  67. Li Q, Winston J, Sarna S. Developmental origins of colon smooth muscle dysfunction in IBS-like rats. Am J Physiol Gastrointest Liver Physiol. 2013;305:G503-12 pubmed publisher
    ..2b channels in adult life. These were the same rats in whom Vip mRNA increased in the colon muscularis externae...
  68. Campregher C, Schmid G, Ferk F, Knasmuller S, Khare V, Kortüm B, et al. MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells. PLoS ONE. 2012;7:e50541 pubmed publisher
    ..However, a mutator phenotype is different between species as the genetic positions of repetitive sequences are not conserved. Here we studied the molecular effects of human MSH3-deficiency...
  69. Orlando A, Refolo M, Messa C, Amati L, Lavermicocca P, Guerra V, et al. Antiproliferative and proapoptotic effects of viable or heat-killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 gastric and DLD-1 colon cell lines. Nutr Cancer. 2012;64:1103-11 pubmed publisher
    Data from literature suggest the possible use of probiotics as chemopreventive agents against colon cancer, but few investigations are available on their effects on gastric cancer proliferation...
  70. Nath B, Nath L. Design, development and optimization of oral colon targeted drug delivery system of azathioprine using biodegradable polymers. Pharm Dev Technol. 2013;18:1131-9 pubmed publisher
    The present study was aimed at designing a microflora triggered colon targeted drug delivery system (MCDDS) based on swellable polysaccharide, Sterculia gum in combination with biodegradable polymers with a view to specifically deliver ..
  71. Hoshi N, Schenten D, Nish S, Walther Z, Gagliani N, Flavell R, et al. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun. 2012;3:1120 pubmed publisher
    ..Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(s) responsible for the development of colitis are currently unknown...
  72. Granlund A, Flatberg A, Østvik A, Drozdov I, Gustafsson B, Kidd M, et al. Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis. PLoS ONE. 2013;8:e56818 pubmed publisher
    ..A meta-analysis including all available, comparable data was used to explore important aspects of IBD inflammation, thereby validating consistent gene expression patterns...