large intestine

Summary

Summary: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.

Top Publications

  1. Kawamata K, Hayashi H, Suzuki Y. Chloride-dependent bicarbonate secretion in the mouse large intestine. Biomed Res. 2006;27:15-21 pubmed
    ..to limit the mucosal acid damage due to HCl secreted in the stomach or organic acids produced in the large intestine. We studied HCO(3)(-) secretion in the mouse large intestine with isolated tissues mounted in chambers by ..
  2. Ramirez Lorca R, Muñoz Cabello A, Toledo Aral J, Ilundáin A, Echevarria M. Aquaporins in chicken: localization of ck-AQP5 along the small and large intestine. Comp Biochem Physiol A Mol Integr Physiol. 2006;143:269-77 pubmed
    ..This work confirmed the presence of AQPs in chicken, and showed that chicken and mammalian AQPs share a high degree of similarity in nucleotide sequence and tissue distribution...
  3. Snover D. Serrated polyps of the large intestine. Semin Diagn Pathol. 2005;22:301-8 pubmed
    Serrated polyps of the large intestine comprise a family of lesions bearing some histological similarities, including an overall serrated configuration caused at least in part by inhibition of apoptosis by mutations in one of two genes...
  4. Ostanin D, Pavlick K, Bharwani S, D Souza D, Furr K, Brown C, et al. T cell-induced inflammation of the small and large intestine in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2006;290:G109-19 pubmed
  5. Rondon L, Rayssiguier Y, Mazur A. Dietary inulin in mice stimulates Mg2+ absorption and modulates TRPM6 and TRPM7 expression in large intestine and kidney. Magnes Res. 2008;21:224-31 pubmed
    ..To determine the modulation of TRPM6 and TRPM7 expression in kidney and large intestine by long-chain inulin ingestion, C57B16J mice were fed a control or a long-chain inulin enriched diet (65 g of ..
  6. Gregorieff A, Pinto D, Begthel H, Destree O, Kielman M, Clevers H. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology. 2005;129:626-38 pubmed
    ..To address this issue, we examined the expression pattern of all Wnts, Frizzleds (Fzs), low-density lipoprotein receptor-related proteins, Wnt antagonists, and T-cell factors in the murine small intestine and colon and adenomas...
  7. Xue Y, Johnson R, Desmet M, Snyder P, Fleet J. Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine. Mol Cancer Res. 2010;8:1095-104 pubmed publisher
    ..to create a transgenic mouse with Cre recombinase (Cre) expression limited to the epithelial cells of the large intestine and used this model to study colon cancer driven by adenomatosis polyposis coli (APC) gene inactivation...
  8. Jaganath I, Mullen W, Edwards C, Crozier A. The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res. 2006;40:1035-46 pubmed
    ..Metabolites appeared in blood after 4 h indicating absorption from the large intestine. Nine metabolites of rutin were detected in urine but with considerable variation in total amount (40 +/- 1-..
  9. Hong M, Turner N, Carroll R, Chapkin R, Lupton J. Differential response to DNA damage may explain different cancer susceptibility between small and large intestine. Exp Biol Med (Maywood). 2005;230:464-71 pubmed
    Although large intestine (LI) cancer is the second-leading cause of cancer-related deaths in the United States, small intestine (SI) cancer is relatively rare...

More Information

Publications62

  1. Crawford C, Sepulveda M, Elliott J, Harris P, Bailey S. Dietary fructan carbohydrate increases amine production in the equine large intestine: implications for pasture-associated laminitis. J Anim Sci. 2007;85:2949-58 pubmed
    ..The fermentation of carbohydrate in the cecum and large intestine results in the production of lactic acid and other toxins or "laminitis trigger factors...
  2. Kiesslich R, Goetz M, Angus E, Hu Q, Guan Y, Potten C, et al. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology. 2007;133:1769-78 pubmed
    ..The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding...
  3. Hastie P, Mitchell K, Murray J. Semi-quantitative analysis of Ruminococcus flavefaciens, Fibrobacter succinogenes and Streptococcus bovis in the equine large intestine using real-time polymerase chain reaction. Br J Nutr. 2008;100:561-8 pubmed publisher
    ..The present study also indicates that the preservation method of digesta affects levels of bacteria detected...
  4. Li B, Shi Y, He X, Zou S, Zhou S, Dong M, et al. Primary non-Hodgkin lymphomas in the small and large intestine: clinicopathological characteristics and management of 40 patients. Int J Hematol. 2008;87:375-381 pubmed publisher
    ..characteristics and optimal treatment modalities of primary non-Hodgkin lymphoma (NHL) in the small and large intestine. Forty patients with primary NHL in the small and large intestine were studied retrospectively...
  5. Freeman H. "Melanosis" in the small and large intestine. World J Gastroenterol. 2008;14:4296-9 pubmed
    ..If detected, removal and further histopathologic analysis of the polyp may be facilitated...
  6. Maathuis A, Hoffman A, Evans A, Sanders L, Venema K. The effect of the undigested fraction of maize products on the activity and composition of the microbiota determined in a dynamic in vitro model of the human proximal large intestine. J Am Coll Nutr. 2009;28:657-66 pubmed
    ..The fibers tested were glucose-based and had variable structures, including 2 resistant starch preparations, soluble corn fiber, pullulan, and soluble fiber dextrin...
  7. Blachier F, Davila A, Mimoun S, Benetti P, Atanasiu C, Andriamihaja M, et al. Luminal sulfide and large intestine mucosa: friend or foe?. Amino Acids. 2010;39:335-47 pubmed publisher
    Hydrogen sulfide (H(2)S) is present in the lumen of the human large intestine at millimolar concentrations...
  8. Louis P, Flint H. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett. 2009;294:1-8 pubmed publisher
    ..Populations of F. prausnitzii are reported to be decreased in Crohn's disease, for example, while populations of Roseburia relatives appear to be particularly sensitive to the diet composition in human volunteer studies...
  9. Horne S, Mattson K, Prüss B. An Escherichia coli aer mutant exhibits a reduced ability to colonize the streptomycin-treated mouse large intestine. Antonie Van Leeuwenhoek. 2009;95:149-58 pubmed publisher
    ..namely growth on sugar acids was tested 'in vitro' with Phenotype MicroArrays and colonization of the mouse large intestine was tested 'in vivo'...
  10. Bell L, Else K. Mechanisms of leucocyte recruitment to the inflamed large intestine: redundancy in integrin and addressin usage. Parasite Immunol. 2008;30:163-70 pubmed publisher
    ..muris and mounted a more Th1-biased immune response. Interestingly, CD4+T cells, but not eosinophils, were able to infiltrate the caecum, showing different levels of redundancy between leucocyte subsets during infection...
  11. Chang S, Cha H, Uematsu S, Akira S, Igarashi O, Kiyono H, et al. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008;180:1609-18 pubmed
    ..numbers of Ag-specific IgA and IgG Ab-secreting cells (ASCs) were detected in the lamina propria of the large intestine of mice vaccinated s.c.-IR...
  12. Lundin A, Bok C, Aronsson L, Björkholm B, Gustafsson J, Pott S, et al. Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol. 2008;10:1093-103 pubmed
    Separating the large intestine from gut flora is a robust layer of epithelial cells. This barrier is armed with an array of recognizing receptors that collectively set the host innate response...
  13. Kovatcheva Datchary P, Egert M, Maathuis A, Rajilić Stojanović M, De Graaf A, Smidt H, et al. Linking phylogenetic identities of bacteria to starch fermentation in an in vitro model of the large intestine by RNA-based stable isotope probing. Environ Microbiol. 2009;11:914-26 pubmed publisher
    ..Bifidobacterium adolescentis and Eubacterium rectale might be further involved in the trophic chain...
  14. Wu H, Yao Y, Shen X, Tan L, Shi Y, Yang Y, et al. [Comparative study on infrared radiation spectrum of yuan point and Xiahe point of the large intestine channel in the patient of ulcerative colitis]. Zhongguo Zhen Jiu. 2008;28:49-55 pubmed
    ..To probe the diagnostic value of the infrared radiation spectrum of acupoint for ulcerative colitis (UC)...
  15. Sandmeier D, Benhattar J, Martin P, Bouzourene H. Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps. Histopathology. 2009;55:206-13 pubmed publisher
  16. Canaparo R, Nordmark A, Finnstrom N, Lundgren S, Seidegard J, Jeppsson B, et al. Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples. Basic Clin Pharmacol Toxicol. 2007;100:240-8 pubmed
    ..different cytochromes P450 3A (CYP3A4, CYP3A5, and CYP3A7) and P-glycoprotein (ABCB1) genes along the human large intestine in paired tumour and normal samples...
  17. Rondon L, Groenestege W, Rayssiguier Y, Mazur A. Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine. Am J Physiol Regul Integr Comp Physiol. 2008;294:R2001-7 pubmed publisher
    ..Further studies of these mice strains could improve our understanding of the genetics of Mg(2+) homeostasis...
  18. Munakata K, Yamamoto M, Anjiki N, Nishiyama M, Imamura S, Iizuka S, et al. Importance of the interferon-alpha system in murine large intestine indicated by microarray analysis of commensal bacteria-induced immunological changes. BMC Genomics. 2008;9:192 pubmed publisher
    ..development and function of host immune systems, the underlying mechanisms, especially those involved in the large intestine (LI), remain unknown...
  19. Sawabe K, Saeki Y, Ohashi A, Mamada K, Wakasugi K, Matsuoka H, et al. Tetrahydrobiopterin in intestinal lumen: its absorption and secretion in the small intestine and the elimination in the large intestine. J Inherit Metab Dis. 2009;32:79-85 pubmed publisher
    ..In these mice, biopterin appeared in the large intestine, caecum and colon, 2 h after the administration...
  20. Bellgard M, Wanchanthuek P, La T, Ryan K, Moolhuijzen P, Albertyn Z, et al. Genome sequence of the pathogenic intestinal spirochete brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine. PLoS ONE. 2009;4:e4641 pubmed publisher
    Brachyspira hyodysenteriae is an anaerobic intestinal spirochete that colonizes the large intestine of pigs and causes swine dysentery, a disease of significant economic importance. The genome sequence of B...
  21. Garcia Miranda P, Garcia Delgado M, Peral M, Calonge M, Ilundain A. Ontogeny regulates creatine metabolism in rat small and large intestine. J Physiol Pharmacol. 2009;60:127-33 pubmed
    ..The small and large intestine express AGAT and GAMT mRNAs. Maturation decreased AGAT mRNA abundance without affecting that of GAMT...
  22. Ling B, Mohan M, Lackner A, Green L, Marx P, Doyle L, et al. The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection. J Infect Dis. 2010;202:1846-54 pubmed publisher
    ..These data indicate that the large intestine is a major viral reservoir in LTNPs, which may be the result of persistent, latently infected cells and ..
  23. Raschka L, Daniel H. Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats. Bone. 2005;37:728-35 pubmed
    ..assessed the effects of fermentation of inulin-type fructans on transepithelial calcium transport in rat large intestine. Transepithelial calcium fluxes in vitro (Ussing chamber), effects on gene expression, mucosal morphology, ..
  24. Resendiz Albor A, Esquivel R, López Revilla R, Verdin L, Moreno Fierros L. Striking phenotypic and functional differences in lamina propria lymphocytes from the large and small intestine of mice. Life Sci. 2005;76:2783-803 pubmed
    Although intraepithelial T lymphocytes of the large intestine (LI) are known to differ from those of the small intestine (SI) in phenotype and function, differences in LI and SI lamina propria (LP) lymphocyte populations have not been ..
  25. Holzinger A, Mittal R, Kachel W, Priessmann H, Hammel M, Ihrler S, et al. A novel 17 bp deletion in the PHOX2B gene causes congenital central hypoventilation syndrome with total aganglionosis of the small and large intestine. Am J Med Genet A. 2005;139:50-1 pubmed
  26. Oberhofer D, Rumenjak V, Lazić J, Vucić N. [Inflammatory indicators in patients after surgery of the large intestine]. Acta Med Croatica. 2006;60:429-33 pubmed
  27. De Graaf A, Venema K. Gaining insight into microbial physiology in the large intestine: a special role for stable isotopes. Adv Microb Physiol. 2008;53:73-168 pubmed
    The importance of the human large intestine for nutrition, health, and disease, is becoming increasingly realized...
  28. LaPointe L, Dunne R, Brown G, Worthley D, Molloy P, Wattchow D, et al. Map of differential transcript expression in the normal human large intestine. Physiol Genomics. 2008;33:50-64 pubmed
    ..To explore the gene expression change along the proximal-distal axis of the large intestine, we analyzed microarray data in 184 normal human specimens using univariate and multivariate techniques...
  29. Little M, Bell L, Cliffe L, Else K. The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris. J Immunol. 2005;175:6713-22 pubmed
    ..helminth Trichuris muris, the local effector mechanism culminating in the expulsion of worms from the large intestine is not known...
  30. Kaji I, Karaki S, Fukami Y, Terasaki M, Kuwahara A. Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine. Am J Physiol Gastrointest Liver Physiol. 2009;296:G971-81 pubmed publisher
    ..Here, we investigated the physiological function and expression of T2R in human and rat large intestine using various physiological and molecular biological techniques...
  31. Fleckenstein J, Lill C, Lüdtke R, Gleditsch J, Rasp G, Irnich D. A single point acupuncture treatment at large intestine meridian: a randomized controlled trial in acute tonsillitis and pharyngitis. Clin J Pain. 2009;25:624-31 pubmed publisher
    ..This study was established to examine the immediate pain alleviating effect of a single point acupuncture treatment applied to the large intestine meridian of patients with sore throat.
  32. Forest V, Pierre F, Bassonga E, Meflah K, Olivier C, Menanteau J. Apc+/Min colonic epithelial cells express TNF receptors and ICAM-1 when they are co-cultured with large intestine intra-epithelial lymphocytes. Cell Immunol. 2003;223:70-6 pubmed
    ..The present study attempts to determine if APC inactivation induces changes in the cross-talk between IEC and large intestine IEL (LI-IEL) through intercellular adhesion molecule (ICAM-1)/leukocyte function-associated (LFA-1) ..
  33. Magee E, Richardson C, Hughes R, Cummings J. Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humans. Am J Clin Nutr. 2000;72:1488-94 pubmed
    ..Sulfide generation in the colon is probably driven by dietary components such as sulfur-containing amino acids (SAAs) and inorganic sulfur (eg, sulfite)...
  34. Prins N, Akkermans L, Lefebvre R, Schuurkes J. 5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle. Br J Pharmacol. 2000;131:927-32 pubmed
    5-HT(4) receptors mediate circular muscle relaxation in both human and canine large intestine, but this phenomenon alone can not explain the improvement in colonic motility induced by selective 5-HT(4) receptor agonists in vivo...
  35. Potten C, Grant H. The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine. Br J Cancer. 1998;78:993-1003 pubmed
    ..Apoptosis in the large intestine is generally lower in frequency than in the small intestine and, for the mid-colonic and rectal regions, has ..
  36. Barkla D, Gibson P. The fate of epithelial cells in the human large intestine. Pathology. 1999;31:230-8 pubmed
    ..Apoptotic cells were rarely observed in the crypt epithelium. The findings of this study support the "recycling" model of epithelial cell death in the surface compartment of the human colon...
  37. Hoyes K, Cai W, Potten C, Hendry J. Effect of bcl-2 deficiency on the radiation response of clonogenic cells in small and large intestine, bone marrow and testis. Int J Radiat Biol. 2000;76:1435-42 pubmed
    ..The purpose of this study was to investigate the role of bcl-2 in the clonogenic radiation response of intestinal crypts, bone marrow progenitor cells and testicular stem cells...
  38. Combe E, Pirman T, Stekar J, Houlier M, Mirand P. Differential effect of lentil feeding on proteosynthesis rates in the large intestine, liver and muscle of rats. J Nutr Biochem. 2004;15:12-7 pubmed
    The aim of this work was to test the hypothesis that the trophic effect of lentil feeding on large intestine results from a stimulation of protein synthesis and to determine whether it interferes with protein metabolism in other ..
  39. Tsukahara T, Iwasaki Y, Nakayama K, Ushida K. Stimulation of butyrate production in the large intestine of weaning piglets by dietary fructooligosaccharides and its influence on the histological variables of the large intestinal mucosa. J Nutr Sci Vitaminol (Tokyo). 2003;49:414-21 pubmed
    Fructooligosaccharides (FOS) reach the large intestine and are fermented into short-chain fatty acids (SCFA), lactate, and carbon dioxide...
  40. Ichikawa H, Shineha R, Satomi S, Sakata T. Gastric or rectal instillation of short-chain fatty acids stimulates epithelial cell proliferation of small and large intestine in rats. Dig Dis Sci. 2002;47:1141-6 pubmed
    ..The rectal route was slightly more effective than the gastric route. The above results indicated that the instillation of short-chain fatty acids orally or rectally stimulated gut epithelial cell proliferation...
  41. D Antona G, Hennig G, Costa M, Humphreys C, Brookes S. Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps. Neurogastroenterol Motil. 2001;13:483-92 pubmed
    ..6 mm s(-1). Our data revealed that myogenic and neurogenic patterns of propagated contractions in the colon occur in isolated preparations and are involved in emptying the colon...
  42. Kozaeva L, Korobov N, Medvedev O. [The role of alpha2-adrenergic and I1-imidazoline receptors in the effects of clonidine and moxonidine on isolated large intestine of mice]. Eksp Klin Farmakol. 2005;68:36-8 pubmed
    ..moxonidine to interact with alpha2-adreno- and I1-imidazoline receptors was studied on isolated segments of large intestine of mice. Both drugs induced dose-dependent contractions in longitudinal muscles of the intestine segments...
  43. Karlsson N, Herrmann A, Karlsson H, Johansson M, Carlstedt I, Hansson G. The glycosylation of rat intestinal Muc2 mucin varies between rat strains and the small and large intestine. A study of O-linked oligosaccharides by a mass spectrometric approach. J Biol Chem. 1997;272:27025-34 pubmed
    ..The expression of the rat Muc2 in the large intestine was confirmed immunochemically and by Northern blotting...
  44. Li A, Hasui K, Yonezawa S, Shirahama H, Kitajima S, Sato E. Immunohistochemical estimation of in-situ cell cycle time in neoplastic epithelial cells in human large intestine: a new cell proliferation index. Hum Cell. 2000;13:117-25 pubmed
    ..arbitrary unit (AU), In order to see the nature of in-situ Tc in the adenoma-carcinoma sequence in the human large intestine, the in-situ Tc in 27 cases of adenoma and 71 cases of adenocarcinoma with adenoma components in the human ..
  45. Duncan S, Barcenilla A, Stewart C, Pryde S, Flint H. Acetate utilization and butyryl coenzyme A (CoA):acetate-CoA transferase in butyrate-producing bacteria from the human large intestine. Appl Environ Microbiol. 2002;68:5186-90 pubmed
    ..These results demonstrate that different functionally distinct groups of butyrate-producing bacteria are present in the human large intestine.
  46. Darfeuille Michaud A. Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease. Int J Med Microbiol. 2002;292:185-93 pubmed
  47. Amo K, Tanaka Taya K, Inagi R, Miyagawa H, Miyoshi H, Okusu I, et al. Human herpesvirus 6B infection of the large intestine of patients with diarrhea. Clin Infect Dis. 2003;36:120-3 pubmed
    ..Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells...
  48. Møller A, Leatham M, Conway T, Nuijten P, de Haan L, Krogfelt K, et al. An Escherichia coli MG1655 lipopolysaccharide deep-rough core mutant grows and survives in mouse cecal mucus but fails to colonize the mouse large intestine. Infect Immun. 2003;71:2142-52 pubmed
    The ability of E. coli strains to colonize the mouse large intestine has been correlated with their ability to grow in cecal and colonic mucus. In the present study, an E...
  49. Parlesak A, Ellendt K, Lindros K, Bode C. Acute but not chronic ethanol exposure impairs retinol oxidation in the small and large intestine of the rat. Eur J Nutr. 2005;44:157-62 pubmed
    ..In the present study we investigated how chronic alcohol feeding and acute ethanol exposure affects retinol dehydrogenase activity in the colon and small intestine of the rat...
  50. Armbruster C, Kriwanek S, Roka R. [Spontaneous perforation of the large intestine. Resection with primary anastomosis or staged (Hartmann) procedure?]. Chirurg. 2001;72:910-3 pubmed
    ..In these cases a discontinuity resection is recommended. Primary resection with anastomosis and Hartmann procedure are not competing operations but situation-dependent therapeutic concepts in spontaneous colonic perforation...
  51. Caney S, Day M, Gruffydd Jones T, Helps C, Hirst T, Stokes C. Expression of chemokine receptors in the feline reproductive tract and large intestine. J Comp Pathol. 2002;126:289-302 pubmed
    ..Expression of CXCR4 receptor was also demonstrated immunohistochemically on some lamina propria and intraepithelial cells. The expression of these receptor molecules may be important in mucosal infection with FIV...
  52. Lin Z, Floros J. Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues. Physiol Genomics. 2002;11:235-43 pubmed
    ..The results from 103 heterozygous rats showed an expression profile in large intestine of BB (22%), IB (58%), and MO (20%)...
  53. Pritchard D, Print C, O Reilly L, Adams J, Potten C, Hickman J. Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. Oncogene. 2000;19:3955-9 pubmed
    ..Hence, bcl-w is an important determinant of damage-induced apoptosis in intestinal epithelia, and unlike bcl-2, which regulates only colonic apoptosis, plays a major role in small intestinal epithelium...