goblet cells

Summary

Summary: A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.

Top Publications

  1. Kim Y, Ho S. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep. 2010;12:319-30 pubmed publisher
    ..tract is the front line of innate host defense, largely because of the secretory products of intestinal goblet cells. Goblet cells synthesize secretory mucin glycoproteins (MUC2) and bioactive molecules such as epithelial ..
  2. McGilligan V, Gregory Ksander M, Li D, Moore J, Hodges R, Gilmore M, et al. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS ONE. 2013;8:e74010 pubmed publisher
    ..of this study was to: (1) determine whether NLRP3 is expressed in the conjunctiva and (2) determine whether goblet cells specifically contribute to innate mediated inflammation via secretion of IL-1?...
  3. Dartt D, Hodges R, Li D, Shatos M, Lashkari K, Serhan C. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011;186:4455-66 pubmed publisher
    ..Throughout the conjunctiva are goblet cells that secrete mucins to protect the eye...
  4. Corrales R, de Paiva C, Li D, Farley W, Henriksson J, Bergmanson J, et al. Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011;52:3492-9 pubmed publisher
    ..To evaluate the effects of desiccating stress on conjunctival goblet cell density and morphology and the expression of cornified envelope precursors by the ocular surface epithelia...
  5. Hasnain S, Gallagher A, Grencis R, Thornton D. A new role for mucins in immunity: insights from gastrointestinal nematode infection. Int J Biochem Cell Biol. 2013;45:364-74 pubmed publisher
    ..These enormous O-linked glycoproteins are synthesised, stored and secreted by goblet cells that are also the source of other protective factors...
  6. Li D, Carozza R, Shatos M, Hodges R, Dartt D. Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2012;53:6928-38 pubmed publisher
    ..The purpose of this study was to determine the Ca(2+)-dependent cellular signaling pathways used by histamine to stimulate conjunctival goblet cell secretion...
  7. VanDussen K, Carulli A, Keeley T, Patel S, Puthoff B, Magness S, et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. 2012;139:488-97 pubmed publisher
    ..Our findings suggest that Notch targets distinct progenitor cell populations to maintain adult intestinal stem cells and to regulate cell fate choice to control epithelial cell homeostasis. ..
  8. van Es J, De Geest N, van de Born M, Clevers H, Hassan B. Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nat Commun. 2010;1:18 pubmed publisher
    ..results in the complete loss of proliferating crypt progenitors due to their conversion into post-mitotic goblet cells. The basic helix-loop-helix transcription factor Math1 is essential for intestinal secretory cell ..
  9. Capuano M, Iaffaldano L, Tinto N, Montanaro D, Capobianco V, Izzo V, et al. MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients. PLoS ONE. 2011;6:e29094 pubmed publisher
    ..NOTCH1, KLF4 signals and the number of goblet cells were lower in small intestine of children with active CD and in those on a GFD than in controls, whereas more ..

More Information

Publications62

  1. Fasina Y, Hoerr F, McKee S, Conner D. Influence of Salmonella enterica serovar Typhimurium infection on intestinal goblet cells and villous morphology in broiler chicks. Avian Dis. 2010;54:841-7 pubmed
    ..Such barriers include the mucus layer (composed of mucins secreted by goblet cells) and the underlying epithelium...
  2. Yeung T, Gandhi S, Bodmer W. Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2011;108:4382-7 pubmed publisher
    ..of CDX1 reduces lumen formation but does not affect goblet cell formation, suggesting that enterocytes and goblet cells form from different progenitor cells...
  3. Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, et al. Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm Bowel Dis. 2011;17:2251-60 pubmed publisher
    ..which binds to the 5' promoter region of Hath1, resulted in suppression of the phenotypic gene expression for goblet cells. In UC, the cooperation of aberrant expression of HES1 and the disappearance of caudal type homeobox 2 (CDX2) ..
  4. Mushaben E, Kramer E, Brandt E, Khurana Hershey G, Le Cras T. Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma. J Immunol. 2011;187:5756-63 pubmed publisher
    ..Airway hyperreactivity (AHR), IgE, inflammatory cells, cytokines, leukotrienes, goblet cells, and activated T cells were assessed...
  5. Asada R, Saito A, Kawasaki N, Kanemoto S, Iwamoto H, Oki M, et al. The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. J Biol Chem. 2012;287:8144-53 pubmed publisher
    ..Additionally, OASIS is highly expressed in goblet cells of the large intestine...
  6. Chen Y, Lu Y, Li I, Hwang S. Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells. PLoS ONE. 2012;7:e34408 pubmed publisher
    ..However, whether increased endoplasmic reticulum (ER) stress occurs in Agr2(-/-) mice remains a controversial issue...
  7. Doughty M. Goblet cells of the normal human bulbar conjunctiva and their assessment by impression cytology sampling. Ocul Surf. 2012;10:149-69 pubmed publisher
    b>Goblet cells of the conjunctiva are the main source of mucus for the ocular surface...
  8. Li D, Shatos M, Hodges R, Dartt D. Role of PKC? activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013;54:5661-74 pubmed publisher
    ..To determine the order and components of the signaling pathway utilized by epidermal growth factor (EGF) to stimulate conjunctival goblet cell proliferation...
  9. Gersemann M, Wehkamp J, Stange E. Innate immune dysfunction in inflammatory bowel disease. J Intern Med. 2012;271:421-8 pubmed publisher
    ..This is accompanied by an insufficient differentiation from intestinal stem cells towards goblet cells. All these disturbances in the gut barrier shift the balance from epithelial defence towards bacterial offence...
  10. Rothenberg M, Nusse Y, Kalisky T, Lee J, Dalerba P, Scheeren F, et al. Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology. 2012;142:1195-1205.e6 pubmed publisher
    ..Although the colon also contains Lgr5(+) stem cells, it does not contain Paneth cells. We investigated the existence of colonic Paneth-like cells that have a distinct transcriptional signature and support Lgr5(+) stem cells...
  11. Chen Y, Lazarev S, Bahrami A, Noble L, Chen F, Zhou D, et al. Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndrome. Lab Invest. 2012;92:556-70 pubmed publisher
    ..SQM) of the ocular mucosal epithelium is a blinding corneal disease characterized by the loss of conjunctival goblet cells (GCs), pathological ocular surface keratinization and tissue recruitment of immune cells...
  12. Hayashi D, Li D, Hayashi C, Shatos M, Hodges R, Dartt D. Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. Invest Ophthalmol Vis Sci. 2012;53:2993-3003 pubmed publisher
    ..The purpose of this study was to determine the effect of histamine and its receptors on goblet cell secretion...
  13. Plaisancie P, Claustre J, Estienne M, Henry G, Boutrou R, Paquet A, et al. A novel bioactive peptide from yoghurts modulates expression of the gel-forming MUC2 mucin as well as population of goblet cells and Paneth cells along the small intestine. J Nutr Biochem. 2013;24:213-21 pubmed publisher
    ..Oral administration of this peptide to rat pups enhanced the number of goblet cells and Paneth cells along the small intestine...
  14. Jones L, Moussa L, Fulcher M, Zhu Y, Hudson E, O Neal W, et al. VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells. J Physiol. 2012;590:545-62 pubmed publisher
    ..is regulated by specific protein complexes, but the SNARE exocytotic core has not been defined in airway goblet cells. In this study, we identify VAMP8 as one of the SNAREs regulating mucin granule exocytosis...
  15. Hasnain S, Tauro S, Das I, Tong H, Chen A, Jeffery P, et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology. 2013;144:357-368.e9 pubmed publisher
    ..However, it is not clear how immune factors affect ER stress and therefore disease symptoms...
  16. Marko C, Menon B, Chen G, Whitsett J, Clevers H, Gipson I. Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. Am J Pathol. 2013;183:35-48 pubmed publisher
    ..is required for conjunctival goblet cell differentiation and that Spdef(-/-) mice, which lack conjunctival goblet cells, have significantly increased corneal surface fluorescein staining and tear volume, a phenotype consistent with ..
  17. Wrzosek L, Miquel S, Noordine M, Bouet S, Joncquel Chevalier Curt M, Robert V, et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol. 2013;11:61 pubmed publisher
    ..B. thetaiotaomicron is known to use polysaccharides from mucus, but its effect on goblet cells has not been addressed so far. F...
  18. Chen Z, Liang Q, Yu G. Establishment of a rabbit model for keratoconjunctivitis sicca. Cornea. 2011;30:1024-9 pubmed publisher
    ..To establish a rabbit model for keratoconjunctivitis sicca (KCS) to study autologous submandibular gland transfer for treating severe KCS...
  19. Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, et al. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 2011;140:1230-1240.e1-7 pubmed publisher
    ..Furthermore, we investigated whether the induction of goblet cell differentiation that results from loss of Notch requires the transcription factor Krüppel-like factor 4 (Klf4)...
  20. Dubaissi E, Papalopulu N. Embryonic frog epidermis: a model for the study of cell-cell interactions in the development of mucociliary disease. Dis Model Mech. 2011;4:179-92 pubmed publisher
  21. Johansson M, Larsson J, Hansson G. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4659-65 pubmed publisher
    ..organized around the highly glycosylated MUC2 mucin, forming a large, net-like polymer that is secreted by the goblet cells. The inner mucus layer is dense and does not allow bacteria to penetrate, thus keeping the epithelial cell ..
  22. McGuckin M, Linden S, Sutton P, Florin T. Mucin dynamics and enteric pathogens. Nat Rev Microbiol. 2011;9:265-78 pubmed publisher
    ..In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection...
  23. Gomes F, Carvalho D, Machado E, Miranda K. Ultrastructural and functional analysis of secretory goblet cells in the midgut of the lepidopteran Anticarsia gemmatalis. Cell Tissue Res. 2013;352:313-26 pubmed publisher
    ..The identified lepidoptera-specific goblet cells were shown to contain several mitochondria inside microvilli of the goblet cell cavity and a vacuolar H(+)-..
  24. Kenchegowda D, Swamynathan S, Gupta D, Wan H, Whitsett J, Swamynathan S. Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol. 2011;356:5-18 pubmed publisher
    ..Klf5CN conjunctiva lacked goblet cells, demonstrating that Klf5 is required for conjunctival goblet cell development...
  25. Kissoon Singh V, Moreau F, Trusevych E, Chadee K. Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice. Am J Pathol. 2013;182:852-65 pubmed publisher
  26. Pajoohesh Ganji A, Pal Ghosh S, Tadvalkar G, Stepp M. Corneal goblet cells and their niche: implications for corneal stem cell deficiency. Stem Cells. 2012;30:2032-43 pubmed publisher
    b>Goblet cells are terminally differentiated cells secreting mucins and antibacterial peptides that play an important role in maintaining the health of the cornea...
  27. Johansson M. Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins. PLoS ONE. 2012;7:e41009 pubmed publisher
    ..mucin produced in the colon is the Muc2 mucin and as it carries numerous O-glycans, the granulae of the goblet cells producing Muc2 mucin were intensely stained...
  28. de Paiva C, Raince J, McClellan A, Shanmugam K, Pangelinan S, Volpe E, et al. Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011;4:397-408 pubmed publisher
    ..NK depletion in CD1dKO mice had no further effect on the number of PAS+ cells. Taken together, these findings indicate that NKT cells are major sources of IL-13 in the conjunctival mucosa that regulates GC homeostasis...
  29. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, et al. Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J Gastroenterol. 2011;46:191-202 pubmed publisher
    ..The present study aimed to elucidate the regulation of cell formation in the human small intestine using biopsy specimens collected from an entire individual small intestine by DBE...
  30. Okada S, Zhang L, Kreda S, Abdullah L, Davis C, Pickles R, et al. Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium. Am J Respir Cell Mol Biol. 2011;45:253-60 pubmed publisher
    ..In this study, we investigated the contribution of goblet cells to airway epithelial ATP release...
  31. Westerhoff M, Hovan L, Lee C, Hart J. Effects of dropping the requirement for goblet cells from the diagnosis of Barrett's esophagus. Clin Gastroenterol Hepatol. 2012;10:1232-6 pubmed publisher
    ..Gastroenterological Association diagnostic criteria for Barrett's esophagus (BE) require the presence of goblet cells in biopsy specimens of columnar mucosa within the esophagus...
  32. Kovács M, Lakatos P, Papp M, Jacobsen S, Nemes E, Polgár M, et al. Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2012;55:429-35 pubmed
    ..and antibodies against recombinant pancreas antigen (rPAB), as well as the importance of autoantibodies against goblet cells (GAB), is not known in pediatric patients with inflammatory bowel disease (IBD)...
  33. McDole J, Wheeler L, McDonald K, Wang B, Konjufca V, Knoop K, et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature. 2012;483:345-9 pubmed publisher
    ..Using a minimally disruptive in vivo imaging approach we show that in the steady state, small intestine goblet cells (GCs) function as passages delivering low molecular weight soluble antigens from the intestinal lumen to ..
  34. Villenave R, Thavagnanam S, Sarlang S, Parker J, Douglas I, Skibinski G, et al. In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo. Proc Natl Acad Sci U S A. 2012;109:5040-5 pubmed publisher
    ..As such, this model may provide insights into RSV pathogenesis in humans that ultimately lead to successful RSV vaccines or therapeutics...
  35. García I, Etxebarria J, Boto de los Bueis A, Diaz Valle D, Rivas L, Martínez Soroa I, et al. Comparative study of limbal stem cell deficiency diagnosis methods: detection of MUC5AC mRNA and goblet cells in corneal epithelium. Ophthalmology. 2012;119:923-9 pubmed publisher
  36. Moore J, Vasey G, Dartt D, McGilligan V, Atkinson S, Grills C, et al. Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface. Invest Ophthalmol Vis Sci. 2011;52:6174-80 pubmed publisher
    ..To investigate the effect of tear hyperosmolarity and signs of clinical ocular surface pathology on conjunctival goblet cell population...
  37. Turner J, Roger J, Fitau J, Combe D, Giddings J, Heeke G, et al. Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. Am J Respir Cell Mol Biol. 2011;44:276-84 pubmed publisher
    ..These conditions are characterized by an increase in the number of mucus-producing goblet cells in the airways...
  38. Le Cras T, Acciani T, Mushaben E, Kramer E, Pastura P, Hardie W, et al. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2011;300:L414-21 pubmed publisher
    ..This study demonstrates that EGFR signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model...
  39. Gersemann M, Stange E, Wehkamp J. From intestinal stem cells to inflammatory bowel diseases. World J Gastroenterol. 2011;17:3198-203 pubmed publisher
    ..be caused by a missing induction of the goblet cell differentiation factors Hath1 and KLF4 leading to immature goblet cells. This defective Paneth and goblet cell differentiation in Crohn's ileitis and UC may enable the luminal ..
  40. de Paiva C, Villarreal A, Corrales R, Rahman H, Chang V, Farley W, et al. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007;48:2553-60 pubmed
    ..To investigate the role of interferon (IFN)-gamma in the pathogenesis of conjunctival squamous metaplasia in dry eye...
  41. Ehre C, Zhu Y, Abdullah L, Olsen J, Nakayama K, Nakayama K, et al. nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol. 2007;293:C1445-54 pubmed
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  42. Hayes K, Bancroft A, Grencis R. The role of TNF-alpha in Trichuris muris infection II: global enhancement of ongoing Th1 or Th2 responses. Parasite Immunol. 2007;29:583-94 pubmed
    ..muris. Thus, this data demonstrates that TNF-alpha acts to enhance an ongoing immune response but is not necessary for a strong protective Th2 response...
  43. Graham J, Moore J, Jiru X, Moore J, Goodall E, Dooley J, et al. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest Ophthalmol Vis Sci. 2007;48:5616-23 pubmed
    ..To compare the bacterial population of the ocular surface of normal and dry eye subjects using conventional culture and 16S rDNA PCR...
  44. Kalabis J, Li G, Fukunaga Kalabis M, Rustgi A, Herlyn M. Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1182-9 pubmed publisher
    ..In organotypic culture, ET3 increased the number of goblet cells but not of enteroendocrine cells...
  45. Tompkins D, Besnard V, Lange A, Wert S, Keiser A, Smith A, et al. Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS ONE. 2009;4:e8248 pubmed publisher
    The bronchioles of the murine lung are lined by a simple columnar epithelium composed of ciliated, Clara, and goblet cells that together mediate barrier function, mucociliary clearance and innate host defense, vital for pulmonary ..
  46. Dharmani P, Srivastava V, Kissoon Singh V, Chadee K. Role of intestinal mucins in innate host defense mechanisms against pathogens. J Innate Immun. 2009;1:123-35 pubmed publisher
    Gastrointestinal mucins produced by goblet cells comprise the main structural components of the mucus layer...
  47. Barabino S, Rolando M, Chen L, Dana M. Exposure to a dry environment induces strain-specific responses in mice. Exp Eye Res. 2007;84:973-7 pubmed
  48. Leech M, Benson R, de Vries A, Fitch P, Howie S. Resolution of Der p1-induced allergic airway inflammation is dependent on CD4+CD25+Foxp3+ regulatory cells. J Immunol. 2007;179:7050-8 pubmed
    ..Blocking IL-10 receptor function in vivo did not block the anti-inflammatory function of transferred natural Tregs but did restore dMLN IL-5 and IL-13 secretion. Thus natural Tregs can control AAI in an IL-10 independent manner...
  49. Dogru M, Okada N, Asano Kato N, Igarashi A, Fukagawa K, Shimazaki J, et al. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Clin Exp Allergy. 2006;36:1556-65 pubmed
  50. Rios J, Ghinelli E, Gu J, Hodges R, Dartt D. Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation. Invest Ophthalmol Vis Sci. 2007;48:1543-51 pubmed
    ..NT3), and neurotrophin-4 (NT4)-and their receptors (NTrs) TrkA, TrkB, TrkC, and p75 are present in rat conjunctiva and cultured rat goblet cells (CGCs) and whether NTs stimulate glycoconjugate secretion or cell proliferation.
  51. Strugala V, Dettmar P, Pearson J. Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn's disease. Int J Clin Pract. 2008;62:762-9 pubmed publisher
    ..This study investigated the thickness and continuity of the mucus barrier in ulcerative colitis (UC) and Crohn's disease (CD) in comparison to normal controls...
  52. Rios J, Shatos M, Urashima H, Dartt D. Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells. Exp Eye Res. 2008;86:629-36 pubmed publisher
    The purpose of the study was to determine if OPC-12759 stimulates secretion from conjunctival goblet cells in culture and if it activates the EGF receptor (EGFR) and p44/p42 mitogen-activated protein kinase (MAPK) to cause mucin secretion...
  53. Yu K, Lujan R, Marmorstein A, Gabriel S, Hartzell H. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest. 2010;120:1722-35 pubmed publisher
    ..However, immunostaining revealed Best2 localized to the basolateral membrane of mucin-secreting colonic goblet cells, not the apical membrane of Cl--secreting enterocytes...