enterocytes

Summary

Summary: Absorptive cells in the lining of the INTESTINAL MUCOSA. They are differentiated EPITHELIAL CELLS with apical MICROVILLI facing the intestinal lumen. Enterocytes are more abundant in the SMALL INTESTINE than in the LARGE INTESTINE. Their microvilli greatly increase the luminal surface area of the cell by 14- to 40 fold.

Top Publications

  1. Shifrin D, McConnell R, Nambiar R, Higginbotham J, Coffey R, Tyska M. Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Curr Biol. 2012;22:627-31 pubmed publisher
    ..Together, these results suggest that microvillar vesicle shedding represents a novel mechanism for distributing host defense machinery into the intestinal lumen and that microvillus-derived LVs modulate epithelial-microbial interactions...
  2. Siggers R, Hackam D. The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases. Cell Mol Life Sci. 2011;68:3623-34 pubmed publisher
    ..This review will detail the regulatory pathways that govern enterocyte apoptosis, and will explore the role of the innate immune system in the induction of enterocyte apoptosis in gastrointestinal disease...
  3. Dominguez J, Samocha A, Liang Z, Burd E, Farris A, Coopersmith C. Inhibition of IKK? in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality. Crit Care Med. 2013;41:e275-85 pubmed publisher
    ..Nuclear factor-?B is a critical regulator of cell-survival genes and the host inflammatory response. The purpose of this study was to investigate the role of enterocyte-specific NF-kB in sepsis through selective ablation of IkB kinase...
  4. Danielsen E, Hansen G, Rasmussen K, Niels Christiansen L, Frenzel F. Apolipoprotein A-1 (apoA-1) deposition in, and release from, the enterocyte brush border: a possible role in transintestinal cholesterol efflux (TICE)?. Biochim Biophys Acta. 2012;1818:530-6 pubmed publisher
    ..We have previously observed that apolipoprotein A-1 (apoA-1) synthesized by enterocytes of the small intestine is mainly secreted apically into the gut lumen during fasting where its assembly into ..
  5. Reichardt S, Foller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann J, et al. Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes. Endocrinology. 2012;153:1783-94 pubmed publisher
    ..GR(villinCre) mice lacking the GC receptor (GR) in enterocytes served to identify the target cell of GC treatment and the requirement of the GR itself; GR(dim) mice impaired ..
  6. Minnaard J, Rolny I, Perez P. Interaction between Bacillus cereus and cultured human enterocytes: effect of calcium, cell differentiation, and bacterial extracellular factors. J Food Prot. 2013;76:820-6 pubmed publisher
    Bacillus cereus interaction with cultured human enterocytes and the signaling pathways responsible for the biological effects of the infection were investigated...
  7. Meynial Denis D, Bielicki G, Beaufrère A, Mignon M, Mirand P, Renou J. Glutamate and CO2 production from glutamine in incubated enterocytes of adult and very old rats. J Nutr Biochem. 2013;24:688-92 pubmed publisher
    Glutamine is the major fuel for enterocytes and promotes the growth of intestinal mucosa. Although oral glutamine exerts a positive effect on intestinal villus height in very old rats, how glutamine is used by enterocytes is unclear...
  8. Douris N, Kojima S, Pan X, Lerch Gaggl A, Duong S, Hussain M, et al. Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes. Curr Biol. 2011;21:1347-55 pubmed publisher
    ..Mice lacking nocturnin (Noc(-/-) mice) are resistant to diet-induced obesity and hepatic steatosis yet are not hyperactive or hypophagic...
  9. Bouchoux J, Beilstein F, Pauquai T, Guerrera I, Chateau D, Ly N, et al. The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics. Biol Cell. 2011;103:499-517 pubmed publisher
    Intestinal absorption of alimentary lipids is a complex process ensured by enterocytes and leading to TRL [TAG (triacylglycerol)-rich lipoprotein] assembly and secretion...

More Information

Publications62

  1. McElroy S, Hobbs S, Kallen M, Tejera N, Rosen M, Grishin A, et al. Transactivation of EGFR by LPS induces COX-2 expression in enterocytes. PLoS ONE. 2012;7:e38373 pubmed publisher
    ..Taken together, these data show that EGFR plays an important role in LPS-induction of COX-2 expression in enterocytes, which may be one mechanism for EGF in inhibition of NEC.
  2. Bothe M, Mundhenk L, Beck C, Kaup M, Gruber A. Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum. Mol Cells. 2012;33:251-7 pubmed publisher
    ..Our data suggest that the processing of CLCA proteins is more complex than previously recognized...
  3. Wakeman D, Guo J, Santos J, Wandu W, Schneider J, McMellen M, et al. p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. Am J Physiol Gastrointest Liver Physiol. 2012;302:G997-1005 pubmed publisher
    Increased apoptosis in crypt enterocytes is a key feature of intestinal adaptation following massive small bowel resection (SBR). Expression of the proapoptotic factor Bax has been shown to be required for resection-induced apoptosis...
  4. Ranganathan P, Lu Y, Fuqua B, Collins J. Immunoreactive hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes. Biometals. 2012;25:687-95 pubmed publisher
    ..lacking, leading to the hypothesis that an alternate, undiscovered form of Heph could exist in mammalian enterocytes. This possibility was tested using laboratory rodent and cell culture models...
  5. Good M, Siggers R, Sodhi C, Afrazi A, Alkhudari F, Egan C, et al. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A. 2012;109:11330-5 pubmed publisher
    ..fluid did not prevent TLR4 signaling in EGFR- or peroxisome proliferator-activated receptor ?-deficient enterocytes or in mice deficient in intestinal epithelial EGFR, and purified EGF attenuated the exaggerated intestinal ..
  6. Ehrenman K, Wanyiri J, Bhat N, Ward H, Coppens I. Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes. Cell Microbiol. 2013;15:1182-97 pubmed publisher
    ..In this study, we have examined the sources of cholesterol from C.?parvum infecting enterocytes. We illustrated that the intracellular stages of Cryptosporidium as well as the oocysts shed by the host, ..
  7. Do K, Choi H, Kim J, Park S, Kim K, Moon Y. SOCS3 regulates BAFF in human enterocytes under ribosomal stress. J Immunol. 2013;190:6501-10 pubmed publisher
  8. Vannucci F, Foster D, Gebhart C. Laser microdissection coupled with RNA-seq analysis of porcine enterocytes infected with an obligate intracellular pathogen (Lawsonia intracellularis). BMC Genomics. 2013;14:421 pubmed publisher
    ..We used laser capture microdissection coupled with RNA-seq technology to characterize the transcriptional responses of infected enterocytes and the host-pathogen interaction.
  9. Khaldoun S, Emond Boisjoly M, Chateau D, Carrière V, Lacasa M, Rousset M, et al. Autophagosomes contribute to intracellular lipid distribution in enterocytes. Mol Biol Cell. 2014;25:118-32 pubmed publisher
    b>Enterocytes, the intestinal absorptive cells, have to deal with massive alimentary lipids upon food consumption...
  10. Beilstein F, Bouchoux J, Rousset M, Demignot S. Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion. PLoS ONE. 2013;8:e53017 pubmed publisher
    In enterocytes, the dynamic accumulation and depletion of triacylglycerol (TAG) in lipid droplets (LD) during fat absorption suggests that cytosolic LD-associated TAG contribute to TAG-rich lipoprotein (TRL) production...
  11. Choi N, Lucchetta E, Ohlstein B. Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway. Proc Natl Acad Sci U S A. 2011;108:18702-7 pubmed publisher
    ..adult midgut intestinal stem cells (ISCs) maintain tissue homeostasis by producing progeny that replace dying enterocytes and enteroendocrine cells...
  12. Ganguli K, Meng D, Rautava S, Lu L, Walker W, Nanthakumar N. Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation. Am J Physiol Gastrointest Liver Physiol. 2013;304:G132-41 pubmed publisher
    ..After exposure to probiotic conditioned media (PCM), immature human enterocytes, immature human intestinal xenografts, and primary enterocyte cultures of NEC tissue (NEC-IEC) were assayed for ..
  13. Ponnusamy D, Periasamy S, Tripathi B, Pal A. Mycobacterium avium subsp. paratuberculosis invades through M cells and enterocytes across ileal and jejunal mucosa of lambs. Res Vet Sci. 2013;94:306-12 pubmed publisher
    ..All these parameters revealed that Map invaded through M cells and the enterocytes and bacterial translocation across M cells was greater than the enterocytes...
  14. Chen C, Yang G, Geng X, Wang X, Liu Z, Yang P. TNFAIP3 facilitates degradation of microbial antigen SEB in enterocytes. PLoS ONE. 2012;7:e45941 pubmed publisher
    The enterocytes have the potential to absorb noxious substances, such as microbial products, from the gut lumen. How the enterocytes process the substances to harmless materials is not fully understood...
  15. Chougule P, Herlenius G, Hernandez N, Patil P, Xu B, Sumitran Holgersson S. Isolation and characterization of human primary enterocytes from small intestine using a novel method. Scand J Gastroenterol. 2012;47:1334-43 pubmed publisher
    Cell culture studies of enterocytes are important in many fields...
  16. Harel E, Rubinstein A, Nissan A, Khazanov E, Nadler Milbauer M, Barenholz Y, et al. Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa. PLoS ONE. 2011;6:e24202 pubmed publisher
    ..Because TfR is expressed in all cell types we hypothesized that its cell surface levels are regulated also in enterocytes. We, therefore, compared TfR expression in healthy and inflamed human colonic mucosa, as well as healthy and ..
  17. Alcamo A, Schanbacher B, Huang H, Nankervis C, Bauer J, Giannone P. Cellular strain amplifies LPS-induced stress signaling in immature enterocytes: potential implications for preterm infant NCPAP. Pediatr Res. 2012;72:256-61 pubmed publisher
    ..We tested the hypothesis that mechanical strain causes an exaggerated enterocyte inflammatory response and decreased enterocyte growth and proliferation in the absence and presence of lipopolysaccharide (LPS)...
  18. Engelking L, McFarlane M, Li C, Liang G. Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes. J Lipid Res. 2012;53:1359-68 pubmed publisher
    ..How these processes are coordinately regulated in enterocytes, the site of cholesterol absorption, is not well understood...
  19. Frochot V, Alqub M, Cattin A, Carrière V, Houllier A, Baraille F, et al. The transcription factor HNF-4?: a key factor of the intestinal uptake of fatty acids in mouse. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1253-63 pubmed publisher
    ..We conclude that the transcription factor HNF-4? is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
  20. Ogaki S, Shiraki N, Kume K, Kume S. Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages. Stem Cells. 2013;31:1086-96 pubmed publisher
    ..Upon prolonged culture on feeder cells, all four intestinal differentiated cell types, the absorptive enterocytes and three types of secretory cells (goblet cells, enteroendocrine cells, and Paneth cells), were efficiently ..
  21. Cherrington N, Estrada T, Frisk H, Canet M, Hardwick R, Dvorak B, et al. The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2013;304:G48-56 pubmed publisher
    ..These data suggest the gut-liver axis should be considered when therapeutic modalities for NEC are developed...
  22. Kurahashi T, Konno T, Otsuki N, Kwon M, Tsunoda S, Ito J, et al. A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice. FEBS Lett. 2012;586:4289-95 pubmed publisher
    ..were secreted to the blood in the form of triglyceride-rich lipoprotein, more lipid droplets accumulated in the enterocytes of Sod1-knockout mice fed a high-fat diet...
  23. Ren H, Liu R, Wang Z, Cui J. Construction and use of a Trichinella spiralis phage display library to identify the interactions between parasite and host enterocytes. Parasitol Res. 2013;112:1857-63 pubmed publisher
    ..It is speculated that the molecular interactions between the parasite and host enterocytes may mediate the recognition and invasion of IECs by T. spiralis...
  24. Qin B, Dawson H, Schoene N, Polansky M, Anderson R. Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes. Nutrition. 2012;28:1172-9 pubmed publisher
    ..The aim of the study was to investigate the effects of a CE on the primary enterocytes of chow-fed rats.
  25. Bourzac J, L Ériger K, Larrivée J, Arguin G, Bilodeau M, Stankova J, et al. Glucose transporter 2 expression is down regulated following P2X7 activation in enterocytes. J Cell Physiol. 2013;228:120-9 pubmed publisher
    ..Although the complete mechanism regulating Glut2 internalization following P2X7 activation is not fully understood, modulation of P2X7 receptor activation could represent an interesting approach to regulate intestinal glucose absorption...
  26. Richter J, Schanbacher B, Huang H, Xue J, Bauer J, Giannone P. LPS-binding protein enables intestinal epithelial restitution despite LPS exposure. J Pediatr Gastroenterol Nutr. 2012;54:639-44 pubmed publisher
    ..Lipopolysaccharide (LPS)-binding protein (LBP) is secreted by enterocytes in response to inflammatory stimuli and has concentration-dependent effects...
  27. Seisenbacher G, Hafen E, Stocker H. MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. PLoS Genet. 2011;7:e1002168 pubmed publisher
    ..of the gut epithelium by intestinal stem cells contributes to gut homeostasis, but how the differentiated enterocytes are protected against stressors is less well understood...
  28. Kujala P, Raymond C, Romeijn M, Godsave S, van Kasteren S, Wille H, et al. Prion uptake in the gut: identification of the first uptake and replication sites. PLoS Pathog. 2011;7:e1002449 pubmed publisher
    ..was transiently detectable at 1 day post feeding (dpf) within large multivesicular LAMP1-positive endosomes of enterocytes in the follicle-associated epithelium (FAE) and at much lower levels within M cells...
  29. Pejchal J, Novotný J, Mařák V, Osterreicher J, Tichy A, Vavrova J, et al. Activation of p38 MAPK and expression of TGF-?1 in rat colon enterocytes after whole body ?-irradiation. Int J Radiat Biol. 2012;88:348-58 pubmed publisher
    ..the p38 mitogen-activated protein kinase (p38) phosphorylation and transforming growth factor beta 1 (TGF-?1) expression in rat colon enterocytes after irradiation and their contribution to pathology of intestinal radiation disease.
  30. Miron N, Cristea V. Enterocytes: active cells in tolerance to food and microbial antigens in the gut. Clin Exp Immunol. 2012;167:405-12 pubmed publisher
    b>Enterocytes used to be studied particularly in terms of digestion protagonists...
  31. Pan X, Hussain M. Gut triglyceride production. Biochim Biophys Acta. 2012;1821:727-35 pubmed publisher
    ..hydrolyzed in the intestinal lumen to free fatty acids (FFA) and monoacylglycerols (MAG), which are taken up by enterocytes from their apical side, transported to the endoplasmic reticulum (ER) and resynthesized into TAG...
  32. Jiang W, Wu P, Kuang S, Liu Y, Jiang J, Hu K, et al. Myo-inositol prevents copper-induced oxidative damage and changes in antioxidant capacity in various organs and the enterocytes of juvenile Jian carp (Cyprinus carpio var. Jian). Aquat Toxicol. 2011;105:543-51 pubmed publisher
    ..Jian) in vivo and in their enterocytes in vitro. First, oxidative stress was established by exposing fish to different concentrations of Cu (0-7...
  33. Lahar N, Lei N, Wang J, Jabaji Z, Tung S, Joshi V, et al. Intestinal subepithelial myofibroblasts support in vitro and in vivo growth of human small intestinal epithelium. PLoS ONE. 2011;6:e26898 pubmed publisher
    ..We believe that the methods described here can be used to explore the molecular basis of human intestinal stem cell support, maintenance, and growth...
  34. Chen C, Sibley E. Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice. Am J Physiol Gastrointest Liver Physiol. 2012;302:G407-19 pubmed publisher
    ..epithelium and lamina propria of Pdx1(flox/flox);VilCre duodenum indicates that the duodenal epithelium lacking Pdx1 may have defects in importing iron through enterocytes, resulting in iron deficiency in Pdx1(flox/flox);VilCre mice.
  35. Shekhawat P, Sonne S, Carter A, Matern D, Ganapathy V. Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health. J Crohns Colitis. 2013;7:e197-205 pubmed publisher
  36. Centanni M, Bergmann S, Turroni S, Hammerschmidt S, Chhatwal G, Brigidi P, et al. Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. Appl Environ Microbiol. 2012;78:2465-9 pubmed publisher
    ..to activate plasminogen, tumor necrosis factor alpha (TNF-?) modulated the plasminogen-mediated bacterium-enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.
  37. Ranganathan P, Lu Y, Fuqua B, Collins J. Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes. Proc Natl Acad Sci U S A. 2012;109:3564-9 pubmed publisher
    Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption...
  38. Nanayakkara M, Lania G, Maglio M, Discepolo V, Sarno M, Gaito A, et al. An undigested gliadin peptide activates innate immunity and proliferative signaling in enterocytes: the role in celiac disease. Am J Clin Nutr. 2013;98:1123-35 pubmed publisher
    ..component of wheat and other cereals, the celiac intestine is characterized by the proliferation of crypt enterocytes with an inversion of the differentiation/proliferation program...
  39. Yokoyama S, Takada K, Hirasawa M, Perera L, Hiroi T. Transgenic mice that overexpress human IL-15 in enterocytes recapitulate both B and T cell-mediated pathologic manifestations of celiac disease. J Clin Immunol. 2011;31:1038-44 pubmed publisher
    ..of CD pathophysiology, we have previously reported that transgenic mice that overexpress human IL-15 in enterocytes (T3(b)-hlL-15 Tg) display many of the T cell-mediated pathologic features seen in CD...
  40. Do K, Choi H, Kim J, Park S, Kim H, Oh C, et al. Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes. Biochem Pharmacol. 2012;84:513-21 pubmed publisher
    ..It can be thus concluded that EGR-1 regulates pro-inflammatory NF-?B activation by LPS via PPAR? although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells...
  41. Reboul E, Borel P. Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes. Prog Lipid Res. 2011;50:388-402 pubmed publisher
    ..Indeed, these drugs may also interfere with lipid vitamin uptake. A better understanding of the molecular mechanisms involved in fat-soluble vitamin and carotenoid absorption is a priority to better optimize their bioavailability...
  42. Foster D, Stauffer S, Stone M, Gookin J. Proteasome inhibition of pathologic shedding of enterocytes to defend barrier function requires X-linked inhibitor of apoptosis protein and nuclear factor ?B. Gastroenterology. 2012;143:133-44.e4 pubmed publisher
    ..We used a piglet model of Cryptosporidium parvum infection to determine how elimination of infected enterocytes is balanced with the need to maintain barrier function.
  43. Dalle F, Wächtler B, L Ollivier C, Holland G, Bannert N, Wilson D, et al. Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol. 2010;12:248-71 pubmed publisher
    ..albicans with oral epithelial cells and enterocytes. Our data demonstrate that adhesion, invasion and damage by C...
  44. Wang X, Zhou B. Dietary zinc absorption: A play of Zips and ZnTs in the gut. IUBMB Life. 2010;62:176-82 pubmed publisher
    ..Zinc transporters with manifested expression in enterocytes include ZnT1, ZnT2, ZnT4, ZnT5, ZnT6, ZnT7, Zip4, and Zip5...
  45. Barone M, Zanzi D, Maglio M, Nanayakkara M, Santagata S, Lania G, et al. Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking. PLoS ONE. 2011;6:e17039 pubmed publisher
    ..immune responses, with IL-15 as a major mediator of the innate immune response, and by proliferation of crypt enterocytes as an early alteration of CD mucosa causing crypts hyperplasia...
  46. Langhans W, Leitner C, Arnold M. Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating. Am J Physiol Regul Integr Comp Physiol. 2011;300:R554-65 pubmed publisher
    ..Finally, cell culture studies indicate that enterocytes oxidize fatty acids, which can be modified pharmacologically...
  47. Chen L, Li P, Wang J, Li X, Gao H, Yin Y, et al. Catabolism of nutritionally essential amino acids in developing porcine enterocytes. Amino Acids. 2009;37:143-52 pubmed publisher
    ..b>Enterocytes were isolated from the jejunum of 0-, 7-, 14-, and 21-day-old pigs, and incubated for 45 min in Krebs buffer ..
  48. Lynes M, Widmaier E. Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet. Life Sci. 2011;88:384-91 pubmed publisher
    ..A model is proposed in which two key proteins, CD36 and the enzyme intestinal alkaline phosphatase, work in a coordinated manner to optimize fatty acid transport across enterocytes in mice.
  49. Barone M, Nanayakkara M, Paolella G, Maglio M, Vitale V, Troiano R, et al. Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation. PLoS ONE. 2010;5:e12246 pubmed publisher
    ..Growth Factor Receptor (EGFR)-dependent actin remodelling and proliferation in cultured cell lines and in enterocytes from CD patients...
  50. Balakrishnan A, Stearns A, Park P, Dreyfuss J, Ashley S, Rhoads D, et al. MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts. Exp Cell Res. 2010;316:3512-21 pubmed publisher
    ..The regulatory mechanisms behind these rhythms remain largely unknown. We hypothesized that microRNAs are involved in mediating these rhythms, and studied the role of microRNAs specifically in modulating intestinal proliferation...
  51. Uchida A, Slipchenko M, Cheng J, Buhman K. Fenofibrate, a peroxisome proliferator-activated receptor ? agonist, alters triglyceride metabolism in enterocytes of mice. Biochim Biophys Acta. 2011;1811:170-6 pubmed publisher
    ..These results suggest that the effects of fenofibrate on the small intestine play a critical role in the hypotriglyceridemic effects of fenofibrate...
  52. Yeh K, Yeh M, Glass J. Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion. Gastroenterology. 2011;141:292-9, 299.e1 pubmed publisher
    ..Despite the importance of Fpn in iron transport, there is controversy about its topology and functional state upon interaction with Heph...
  53. McConnell R, Higginbotham J, Shifrin D, Tabb D, Coffey R, Tyska M. The enterocyte microvillus is a vesicle-generating organelle. J Cell Biol. 2009;185:1285-98 pubmed publisher
    ..In combination, these data show that microvilli function as vesicle-generating organelles, which enable enterocytes to deploy catalytic activities into the intestinal lumen.