short bowel syndrome


Summary: A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.

Top Publications

  1. Matarese L. Nutrition and fluid optimization for patients with short bowel syndrome. JPEN J Parenter Enteral Nutr. 2013;37:161-70 pubmed publisher
    b>Short bowel syndrome (SBS) is characterized by nutrient malabsorption and occurs following surgical resection, congenital defect, or disease of the bowel...
  2. Joly F, Mayeur C, Bruneau A, Noordine M, Meylheuc T, Langella P, et al. Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome. Biochimie. 2010;92:753-61 pubmed publisher
    b>Short bowel syndrome (SBS) is observed in Humans after a large resection of gut...
  3. Eizaguirre I, Aldazabal P, Urkia N, Asensio A, Arenzxana J. Escherichia coli translocation in experimental short bowel syndrome: probiotic supplementation and detection by polymerase chain reaction. Pediatr Surg Int. 2011;27:1301-5 pubmed publisher
    ..than conventional methods in bacterial detection and has not been investigated in experimental models of short bowel syndrome and BT...
  4. Goulet O, Joly F, Corriol O, Colomb Jung V. Some new insights in intestinal failure-associated liver disease. Curr Opin Organ Transplant. 2009;14:256-61 pubmed publisher
    ..Reversal of cholestasis was recently achieved in infants with short bowel syndrome, by replacing the 'reference' soybean oil-based ILE by fish oil-based ILE...
  5. Fitzgibbons S, Ching Y, Valim C, Zhou J, Iglesias J, Duggan C, et al. Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome. J Pediatr Surg. 2009;44:928-32 pubmed publisher
    Although bowel length is an important prognostic variable used in the management of children with short bowel syndrome (SBS), reliable measurements can be difficult to obtain...
  6. Joly F, Mayeur C, Messing B, Lavergne Slove A, Cazals Hatem D, Noordine M, et al. Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2009;297:G116-23 pubmed publisher
    In short bowel syndrome (SBS), although a remaining colon improves patient outcome, there is no direct evidence of a mucosal colonic adaptation in humans...
  7. Morikawa N, Kuroda T, Kitano Y, Tanaka H, Takayasu H, Fujino A, et al. Repeat STEP procedure to establish enteral nutrition in an infant with short bowel syndrome. Pediatr Surg Int. 2009;25:1007-11 pubmed publisher
    ..enteroplasty (STEP) procedure is a safe and successful way to lengthen the small bowel in patients with short bowel syndrome. However, postoperative dilatation of the intestine may occur, which induces bacterial overgrowth and ..
  8. Cole C, Frem J, Schmotzer B, Gewirtz A, Meddings J, Gold B, et al. The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. J Pediatr. 2010;156:941-947.e1 pubmed publisher
    This pilot study in parenteral nutrition-dependent infants with short bowel syndrome (SBS) evaluated the impact of feeding route and intestinal permeability on bloodstream infection (BSI), small bowel bacterial overgrowth (SBBO), and ..
  9. Joly F, Dray X, Corcos O, Barbot L, Kapel N, Messing B. Tube feeding improves intestinal absorption in short bowel syndrome patients. Gastroenterology. 2009;136:824-31 pubmed publisher
    Tube feeding, recommended for patients with short bowel syndrome in only the postoperative period, has not been compared with oral feeding for absorption...

More Information


  1. Spencer A, Kovacevich D, McKinney Barnett M, Hair D, Canham J, Maksym C, et al. Pediatric short-bowel syndrome: the cost of comprehensive care. Am J Clin Nutr. 2008;88:1552-9 pubmed publisher
    ..The comprehensive care of pediatric SBS patients costs significantly more than has previously been estimated. Contrary to previous views, home care significantly increases each year after diagnosis. ..
  2. Thompson J, Weseman R, Rochling F, Mercer D. Current management of the short bowel syndrome. Surg Clin North Am. 2011;91:493-510 pubmed publisher
    b>Short bowel syndrome is a challenging clinical problem that benefits from a multidisciplinary approach. Much progress has recently been made in all aspects of management...
  3. Martinez M, Fabeiro M, Dalieri M, Barcellandi P, Prozzi M, Hernandez J, et al. [Outcome and survival of pediatric Short Bowel Syndrome (SBS)]. Nutr Hosp. 2011;26:239-42 pubmed
    ..045), cholestasis (0.049, admittance to the center before 2000 (p 0.02). SBS had a high mortality and 1/3 of patients could adapt requiring up to 5 years. Adaptation was in relation to anatomic factors. Mortality was related to. ..
  4. Wales P, Christison Lagay E. Short bowel syndrome: epidemiology and etiology. Semin Pediatr Surg. 2010;19:3-9 pubmed publisher
    Pediatric short bowel syndrome (SBS) is most commonly caused by congenital or acquired conditions of the newborn...
  5. Tolga Muftuoglu M, Civak T, Cetin S, Civak L, Gungor O, Saglam A. Effects of probiotics on experimental short-bowel syndrome. Am J Surg. 2011;202:461-8 pubmed publisher
    ..There was no significant difference in these parameters in ileum. This trial clearly has shown that probiotics had a positive impact on jejunum in the experimental SBS. ..
  6. Digalakis M, Papamichail M, Glava C, Grammatoglou X, Sergentanis T, Papalois A, et al. Interposition of a reversed jejunal segment enhances intestinal adaptation in short bowel syndrome: an experimental study on pigs. J Surg Res. 2011;171:551-7 pubmed publisher
    ..Controversy exists about its efficacy in terms of body weight improvement, direction of luminal changes, and underlying mechanisms. This study aims to provide a comprehensive approach...
  7. Olieman J, Poley M, Gischler S, Penning C, Escher J, van den Hoonaard T, et al. Interdisciplinary management of infantile short bowel syndrome: resource consumption, growth, and nutrition. J Pediatr Surg. 2010;45:490-8 pubmed publisher
    To date, there are hardly any data on the treatment costs of infantile short bowel syndrome (SBS), despite growing interest in evidence-based and cost-effective medicine...
  8. Eizaguirre I, García Urkia N, Asensio A, Hijona E, Garcia Arenzana J, Bachiller P, et al. [Adaptation in the small intestine: Effect of minimal enteral nutrition and probiotics on proliferation and apoptosis in the intestinal wall]. Cir Pediatr. 2010;23:118-21 pubmed
    ..p<0.01). MEN and probiotics reduce BT and improve cellular renewal by encouraging the proliferation. MEN also prevents apoptosis. ..
  9. Kelly D. Preventing parenteral nutrition liver disease. Early Hum Dev. 2010;86:683-7 pubmed publisher
    ..The pathogenesis is multifactorial and is related to prematurity, low birth weight, duration of PN, short bowel syndrome requiring multiple laparotomies and recurrent sepsis...
  10. Wallis K, Walters J, Gabe S. Short bowel syndrome: the role of GLP-2 on improving outcome. Curr Opin Clin Nutr Metab Care. 2009;12:526-32 pubmed publisher
    The medical management of short bowel syndrome frequently requires lifelong parenteral nutrition...
  11. Munakata S, Arakawa C, Kohira R, Fujita Y, Fuchigami T, Mugishima H. A case of D-lactic acid encephalopathy associated with use of probiotics. Brain Dev. 2010;32:691-4 pubmed publisher
    ..She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of ..
  12. Seetharam P, Rodrigues G. Short bowel syndrome: a review of management options. Saudi J Gastroenterol. 2011;17:229-35 pubmed publisher
    ..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
  13. Richette P, Ayoub G, Bardin T, Bouvet S, Orcel P, Badran A. Hypomagnesemia and chondrocalcinosis in short bowel syndrome. J Rheumatol. 2005;32:2434-6 pubmed
    ..We describe 3 patients with chronic hypomagnesemia induced by short bowel syndrome who developed symptomatic chondrocalcinosis...
  14. Sukhotnik I, Shehadeh N, Shamir R, Bejar J, Bernshteyn A, Mogilner J. Oral insulin enhances intestinal regrowth following massive small bowel resection in rat. Dig Dis Sci. 2005;50:2379-85 pubmed
    ..on structural intestinal adaptation and enterocyte proliferation and loss via apoptosis in a rat model of short bowel syndrome (SBS)...
  15. Jeppesen P. Growth factors in short-bowel syndrome patients. Gastroenterol Clin North Am. 2007;36:109-21, vii pubmed
  16. DiBaise J, Young R, Vanderhoof J. Intestinal rehabilitation and the short bowel syndrome: part 1. Am J Gastroenterol. 2004;99:1386-95 pubmed
    The management of patients with intestinal failure due to short bowel syndrome (SBS) is complex, requiring a comprehensive approach that frequently necessitates long-term, if not life-long, use of parenteral nutrition (PN)...
  17. Goulet O, Ruemmele F. Causes and management of intestinal failure in children. Gastroenterology. 2006;130:S16-28 pubmed
    ..Causes of severe protracted intestinal failure include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal ..
  18. De Groote M, Frank D, Dowell E, Glode M, Pace N. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J. 2005;24:278-80 pubmed
    ..We used sequencing of the ribosomal operon region and strain typing with pulsed field electrophoresis of the isolates to show identity between the tablet and bloodstream isolates. ..
  19. Ferrone M, Scolapio J. Teduglutide for the treatment of short bowel syndrome. Ann Pharmacother. 2006;40:1105-9 pubmed
    ..application of teduglutide (ALX-0600), a glucagon-like peptide-2 (GLP-2) analog for the treatment of short bowel syndrome (SBS)...
  20. Ekema G, Falchetti D, Boroni G, Tanca A, Altana C, Righetti L, et al. Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids). J Pediatr Surg. 2008;43:1191-5 pubmed publisher
    ..This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids. ..
  21. Thompson J, Langnas A. Surgical approaches to improving intestinal function in the short-bowel syndrome. Arch Surg. 1999;134:706-9; discussion 709-11 pubmed
    ..Success is lowest for procedures designed to prolong intestinal transit time; thus, these procedures should be used only in carefully selected patients. ..
  22. Kim H, Fauza D, Garza J, Oh J, Nurko S, Jaksic T. Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure. J Pediatr Surg. 2003;38:425-9 pubmed
    Bowel lengthening may be beneficial for children with short bowel syndrome. However, current techniques require at least one intestinal anastomosis and place the mesenteric blood supply at risk...
  23. García Urkia N, Asensio A, Zubillaga Azpiroz I, Zubillaga Huici P, Vidales C, Garcia Arenzana J, et al. [Beneficial effects of Bifidobacterium lactis in the prevention of bacterial translocation in experimental short bowel syndrome]. Cir Pediatr. 2002;15:162-5 pubmed
    ..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated...
  24. Florescu D, Hill L, Sudan D, Iwen P. Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review. Pediatr Infect Dis J. 2008;27:1013-9 pubmed publisher
    ..This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the ..
  25. Jeppesen P. Clinical significance of GLP-2 in short-bowel syndrome. J Nutr. 2003;133:3721-4 pubmed
  26. Eizaguirre I, Urkia N, Asensio A, Zubillaga I, Zubillaga P, Vidales C, et al. Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome. J Pediatr Surg. 2002;37:699-702 pubmed
    ..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated...
  27. Weale A, Edwards A, Bailey M, Lear P. Intestinal adaptation after massive intestinal resection. Postgrad Med J. 2005;81:178-84 pubmed
    Patients with short bowel syndrome require long term parenteral nutrition support. However, after massive intestinal resection the intestine undergoes adaptation and nutritional autonomy may be obtained...
  28. Jeppesen P. Glucagon-like peptide-2: update of the recent clinical trials. Gastroenterology. 2006;130:S127-31 pubmed
    ..In this respect, glucagon-like peptide 2 (GLP-2) has received attention. In this review, the nature of the short bowel syndrome is described, and the antisecretory, transit-modulating, but also intestinotrophic effects of GLP-2 are ..
  29. Nightingale J. Management of patients with a short bowel. World J Gastroenterol. 2001;7:741-51 pubmed
    ..The survival of patients with a short bowel, even if they need long-term parenteral nutrition, is good. ..
  30. Achour L, Nancey S, Moussata D, Graber I, Messing B, Flourie B. Faecal bacterial mass and energetic losses in healthy humans and patients with a short bowel syndrome. Eur J Clin Nutr. 2007;61:233-8 pubmed
    ..The error introduced by the faecal bacterial fraction when assessing the extent of nutrient digestibility is small in healthy volunteers; it is more pronounced in patients with SBC, reaching 18% for the digestibility of ingested fat. ..
  31. Wales P, de Silva N, Kim J, Lecce L, Sandhu A, Moore A. Neonatal short bowel syndrome: a cohort study. J Pediatr Surg. 2005;40:755-62 pubmed
    To date, our knowledge of morbidity and mortality in neonatal short bowel syndrome (SBS) is based on individual case series...
  32. Uchida H, Yamamoto H, Kisaki Y, Fujino J, Ishimaru Y, Ikeda H. D-lactic acidosis in short-bowel syndrome managed with antibiotics and probiotics. J Pediatr Surg. 2004;39:634-6 pubmed
    ..Recolonization of the intestine with nonpathogenic floras should be a long-term treatment for D-lactic acidosis. ..
  33. Cella W, Urbano A, Vinhadelli W, Donatti M, Rocha E. Xerophthalmia secondary to short bowel syndrome. J Pediatr Ophthalmol Strabismus. 2002;39:125-7 pubmed
  34. Sentongo T, Cohran V, Korff S, Sullivan C, Iyer K, Zheng X. Intestinal permeability and effects of Lactobacillus rhamnosus therapy in children with short bowel syndrome. J Pediatr Gastroenterol Nutr. 2008;46:41-7 pubmed
    ..the effects of Lactobacillus rhamnosus (also known as LGG) on intestinal permeability (IP) in children with short bowel syndrome (SBS)...
  35. Salvia G, Guarino A, Terrin G, Cascioli C, Paludetto R, Indrio F, et al. Neonatal onset intestinal failure: an Italian Multicenter Study. J Pediatr. 2008;153:674-6, 676.e1-2 pubmed publisher
    ..Cholestatic liver disease was diagnosed in 54% of observed children. An understanding of the incidence, causes, and natural history of intestinal failure would be helpful to appropriately allocate resources and to plan clinical trials. ..
  36. O Keefe S, Buchman A, Fishbein T, Jeejeebhoy K, Jeppesen P, Shaffer J. Short bowel syndrome and intestinal failure: consensus definitions and overview. Clin Gastroenterol Hepatol. 2006;4:6-10 pubmed
    b>Short bowel syndrome (SBS)-associated intestinal failure is a highly disabling condition that impairs quality of life and social integration...
  37. Spencer A, Neaga A, West B, Safran J, Brown P, Btaiche I, et al. Pediatric short bowel syndrome: redefining predictors of success. Ann Surg. 2005;242:403-9; discussion 409-12 pubmed
    To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients...
  38. Duro D, Jaksic T, Duggan C. Multiple micronutrient deficiencies in a child with short bowel syndrome and normal somatic growth. J Pediatr Gastroenterol Nutr. 2008;46:461-4 pubmed publisher
  39. Sukhotnik I, Siplovich L, Shiloni E, Mor Vaknin N, Harmon C, Coran A. Intestinal adaptation in short-bowel syndrome in infants and children: a collective review. Pediatr Surg Int. 2002;18:258-63 pubmed
  40. Javid P, Kim H, Duggan C, Jaksic T. Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. J Pediatr Surg. 2005;40:1019-23; discussion 1023-4 pubmed
    ..The serial transverse enteroplasty (STEP) has been shown to improve nutritional indices in an animal model of short bowel syndrome. The aim of this study was to review short-term surgical and nutritional outcomes in the first cohort of ..
  41. Jeppesen P, Sanguinetti E, Buchman A, Howard L, Scolapio J, Ziegler T, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut. 2005;54:1224-31 pubmed
    Glucagon-like peptide 2 (GLP-2) may improve intestinal absorption in short bowel syndrome (SBS) patients with an end jejunostomy...
  42. Sigalet D. Short bowel syndrome in infants and children: an overview. Semin Pediatr Surg. 2001;10:49-55 pubmed
    b>Short bowel syndrome is a spectrum of malnutrition resulting from inadequate bowel length...
  43. DiBaise J, Young R, Vanderhoof J. Enteric microbial flora, bacterial overgrowth, and short-bowel syndrome. Clin Gastroenterol Hepatol. 2006;4:11-20 pubmed
    ..Because many aspects related to SIBO in the SBS population remain poorly understood, it was our aim to review the current understanding of the gut flora and issues related to SIBO occurring in SBS. ..
  44. Thompson J, DiBaise J, Iyer K, Yeats M, Sudan D. Postoperative short bowel syndrome. J Am Coll Surg. 2005;201:85-9 pubmed
    Unanticipated massive resection after intraabdominal procedures is an increasing cause of short bowel syndrome (SBS). Our aim was to determine the frequency and potential mechanisms of postoperative SBS...
  45. Bartholome A, Albin D, Baker D, Holst J, Tappenden K. Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets. JPEN J Parenter Enteral Nutr. 2004;28:210-22; discussion 222-3 pubmed
    ..Ultimately, butyrate administration may enable an infant with short-bowel syndrome to successfully transition to enteral feedings by maximizing their absorptive area. ..
  46. Wang L, Tang Y, Rubin D, Levin M. Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1559-69 pubmed
    ..directly assess whether chronically administered retinoic acid could stimulate gut adaptation in a model of short bowel syndrome and to address the mechanisms of any such effects, Sprague-Dawley rats were implanted with controlled ..
  47. Mogilner J, Srugo I, Lurie M, Shaoul R, Coran A, Shiloni E, et al. Effect of probiotics on intestinal regrowth and bacterial translocation after massive small bowel resection in a rat. J Pediatr Surg. 2007;42:1365-71 pubmed
    ..intestinal bacterial overgrowth, probiotics (PROs) have been advocated for the treatment of patients with short bowel syndrome (SBS)...
  48. Hasosah M, Lemberg D, Skarsgard E, Schreiber R. Congenital short bowel syndrome: a case report and review of the literature. Can J Gastroenterol. 2008;22:71-4 pubmed
    Congenital short bowel syndrome (SBS) is a rare condition of the newborn, with several reports demonstrating high mortality. A six-week-old boy presented with chronic diarrhea and failure to thrive...
  49. Serrano M, Schmidt Sommerfeld E. Nutrition support of infants with short bowel syndrome. Nutrition. 2002;18:966-70 pubmed
  50. Thompson J. Comparison of massive vs. repeated resection leading to short bowel syndrome. J Gastrointest Surg. 2000;4:101-4 pubmed
    b>Short bowel syndrome can result from either a single massive intestinal resection or repeated lesser resections, which might have prognostic implications...
  51. Messing B, Blethen S, DiBaise J, Matarese L, Steiger E. Treatment of adult short bowel syndrome with recombinant human growth hormone: a review of clinical studies. J Clin Gastroenterol. 2006;40 Suppl 2:S75-84 pubmed
    ..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
  52. Chen Y, Ni Y, Lai H. Gastrocolocutaneous fistula in a child with congenital short bowel syndrome: a rare complication of percutaneous endoscopic gastrostomy. J Formos Med Assoc. 2004;103:306-10 pubmed
    ..We report a case of this complication in a 2-year-old boy with congenital short bowel syndrome with dilated bowel loops who underwent PEG insertion...
  53. Crenn P, Coudray Lucas C, Thuillier F, Cynober L, Messing B. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology. 2000;119:1496-505 pubmed