ileus

Summary

Summary: A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.

Top Publications

  1. Delaney C, Marcello P, Sonoda T, Wise P, Bauer J, Techner L. Gastrointestinal recovery after laparoscopic colectomy: results of a prospective, observational, multicenter study. Surg Endosc. 2010;24:653-61 pubmed publisher
    ..multicenter study was planned to investigate GI recovery, length of hospital stay (LOS), and postoperative ileus (POI)-related morbidity after LC...
  2. Yeh Y, Klinger E, Reddy P. Pharmacologic options to prevent postoperative ileus. Ann Pharmacother. 2009;43:1474-85 pubmed publisher
    To summarize the evidence on pharmacologic options in preventing postoperative ileus (POI)...
  3. van der Doef H, Kokke F, van der Ent C, Houwen R. Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation. Curr Gastroenterol Rep. 2011;13:265-70 pubmed publisher
    Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients...
  4. The F, Cailotto C, Van Der Vliet J, de Jonge W, Bennink R, Buijs R, et al. Central activation of the cholinergic anti-inflammatory pathway reduces surgical inflammation in experimental post-operative ileus. Br J Pharmacol. 2011;163:1007-16 pubmed publisher
    ..the vagus nerve reduces intestinal inflammation following mechanical handling, thereby shortening post-operative ileus in mice...
  5. Story S, Chamberlain R. A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus. Dig Surg. 2009;26:265-75 pubmed publisher
    Postoperative ileus (POI) is a common complication of abdominal and several other surgeries leading to increased hospital stay and healthcare costs...
  6. Buchler M, Seiler C, Monson J, Flamant Y, Thompson Fawcett M, Byrne M, et al. Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study. Aliment Pharmacol Ther. 2008;28:312-25 pubmed
    Post-operative ileus (POI) affects most patients undergoing abdominal surgery...
  7. Sun L, Rommens J, Corvol H, Li W, Li X, Chiang T, et al. Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. Nat Genet. 2012;44:562-9 pubmed publisher
    Variants associated with meconium ileus in cystic fibrosis were identified in 3,763 affected individuals by genome-wide association study (GWAS). Five SNPs at two loci near SLC6A14 at Xq23-24 (minimum P = 1...
  8. Kappler M, Feilcke M, Schroter C, Kraxner A, Griese M. Long-term pulmonary outcome after meconium ileus in cystic fibrosis. Pediatr Pulmonol. 2009;44:1201-6 pubmed publisher
    To identify cystic fibrosis (CF) patients with a history of meconium ileus (MI) and to compare long-term outcome of these patients with CF patients without MI. 370 CF patients who were treated at the Munich CF centre in 2006, mean age 17...
  9. Rauh P, Neye H, Ensberg D, Bönicke P, Georgiew E, Rickes S. [Ultrasonographic diagnosis of a biliary-digestive fistula with gallstone ileus]. Dtsch Med Wochenschr. 2010;135:287-9 pubmed publisher
    ..Percutaneous ultrasound found aerobilia, a biliary-digestive fistula, and an ileus with gallstones within the small bowel. The findings were confirmed at computed tomography...

More Information

Publications62

  1. Emirleroglu M, Ekci B, Durgun V. The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. Bratisl Lek Listy. 2011;112:309-13 pubmed
    The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses.
  2. Monchal T, Hornez E, Bourgouin S, Sbardella F, Baudoin Y, Butin C, et al. Enterolith ileus due to jejunal diverticulosis. Am J Surg. 2010;199:e45-7 pubmed publisher
    ..The authors report a new case of enterolith ileus in a 74-year-old man, due to jejunal diverticulosis, and its successful surgical management in emergency...
  3. Stoffels B, Schmidt J, Nakao A, Nazir A, Chanthaphavong R, Bauer A. Role of interleukin 10 in murine postoperative ileus. Gut. 2009;58:648-60 pubmed publisher
    Intestinal manipulation triggers an inflammatory cascade within the muscularis causing postoperative ileus (POI). The aim of this study was to investigate the recovery and therapeutic potential of interleukin 10 (IL10) for POI...
  4. Stoffels B, Hupa K, Snoek S, van Bree S, Stein K, Schwandt T, et al. Postoperative ileus involves interleukin-1 receptor signaling in enteric glia. Gastroenterology. 2014;146:176-87.e1 pubmed publisher
    Postoperative ileus (POI) is a common consequence of abdominal surgery that increases the risk of postoperative complications and morbidity. We investigated the cellular mechanisms and immune responses involved in the pathogenesis of POI...
  5. Smith V, Schäppi M, Bisset W, Kiparissi F, Jaffe A, Milla P, et al. Lymphocytic leiomyositis and myenteric ganglionitis are intrinsic features of cystic fibrosis: studies in distal intestinal obstruction syndrome and meconium ileus. J Pediatr Gastroenterol Nutr. 2009;49:42-51 pubmed publisher
    ..Full-thickness terminal ileal tissues from 6 children with CF and severe DIOS, 6 infants with complicated meconium ileus (MI), and 6 children with non-CF intestinal atresia were studied...
  6. Copeland D, St Peter S, Sharp S, Islam S, Cuenca A, Tolleson J, et al. Diminishing role of contrast enema in simple meconium ileus. J Pediatr Surg. 2009;44:2130-2 pubmed publisher
    Contrast enema is the initial study of choice for simple meconium ileus to confirm diagnosis and to relieve obstruction...
  7. De Winter B, Bredenoord A, Van Nassauw L, De Man J, De Schepper H, Timmermans J, et al. Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors. Eur J Pharmacol. 2009;615:177-84 pubmed publisher
    ..reflex pathways by inflammatory mediators is postulated as an important pathogenic mechanism in postoperative ileus. In this study, we investigated the involvement of afferent neurons and more specifically the role of the ..
  8. Gorter R, Karimi A, Sleeboom C, Kneepkens C, Heij H. Clinical and genetic characteristics of meconium ileus in newborns with and without cystic fibrosis. J Pediatr Gastroenterol Nutr. 2010;50:569-72 pubmed publisher
    The present study compares the clinical presentation and diagnostic features of meconium ileus (MI) in newborns with and without cystic fibrosis (CF)...
  9. Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, et al. Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via ?7nACh receptors on muscularis macrophages associated with postoperative ileus. Gut. 2011;60:638-47 pubmed publisher
    The main symptom of postoperative ileus (POI) is an intestinal motility disorder in which monocytes/macrophages and neutrophils play crucial roles...
  10. Stengel A, TACHE Y. Ghrelin: new insight to mechanisms and treatment of postoperative gastric ileus. Curr Pharm Des. 2011;17:1587-93 pubmed
    Postoperative gastric ileus develops after abdominal surgery and if prolonged leads to longer hospitalization times...
  11. Cailotto C, Costes L, Van Der Vliet J, van Bree S, Van Heerikhuize J, Buijs R, et al. Neuroanatomical evidence demonstrating the existence of the vagal anti-inflammatory reflex in the intestine. Neurogastroenterol Motil. 2012;24:191-200, e93 pubmed publisher
    ..The expression of c-fos was evaluated at different levels of the neurocircuitry in the course of postoperative ileus (POI) in a mouse model...
  12. Snoek S, Dhawan S, van Bree S, Cailotto C, van Diest S, Duarte J, et al. Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model. Neurogastroenterol Motil. 2012;24:172-84, e91 pubmed publisher
    ..commonly results in inflammation of the bowel wall, which leads to impaired intestinal motility and postoperative ileus (POI). Mast cells have shown to play a key role in the pathogenesis of POI in mouse models and human studies...
  13. Martinez Ramos D, Daroca José J, Escrig Sos J, Paiva Coronel G, Alcalde Sanchez M, Salvador Sanchís J. Gallstone ileus: management options and results on a series of 40 patients. Rev Esp Enferm Dig. 2009;101:117-20, 121-4 pubmed
    Controversy remains about the management of gallstone ileus. While some authors propose enterotomy, others defend the one-stage procedure (simultaneously fistula repair)...
  14. Çavuşoğlu Y, Azili M, Karaman A, Aslan M, Karaman I, Erdogan D, et al. Does gum chewing reduce postoperative ileus after intestinal resection in children? A prospective randomized controlled trial. Eur J Pediatr Surg. 2009;19:171-3 pubmed publisher
  15. Johnson J, Bush A, Buchdahl R. Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis?. Pediatr Pulmonol. 2010;45:951-8 pubmed publisher
    ..of debate as to what extent the long-term outcome of cystic fibrosis (CF) is affected by presenting with meconium ileus (MI)...
  16. Fohl A, Johnson C, Cober M. Stability of extemporaneously prepared acetylcysteine 1% and 10% solutions for treatment of meconium ileus. Am J Health Syst Pharm. 2011;68:69-72 pubmed publisher
    The stability of extemporaneously prepared acetylcysteine 1% and 10% solutions for treatment of meconium ileus was evaluated.
  17. Boeckxstaens G, de Jonge W. Neuroimmune mechanisms in postoperative ileus. Gut. 2009;58:1300-11 pubmed publisher
    Postoperative ileus (POI) is a common clinical condition arising after almost every abdominal surgical procedure, leading to increased patient morbidity and prolonged hospitalisation...
  18. Li Y, Li Y, Ni J, Chen C, Lv S, Chai S, et al. Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus. Neurogastroenterol Motil. 2010;22:350-e88 pubmed publisher
    ..to characterize the possible influence of CB(1) and CB(2) receptors on motility impairment in a model of septic ileus. METHODS Lipopolysaccharide (LPS) injections were used to mimic pathophysiological features of septic ileus...
  19. Ludwig K, Viscusi E, Wolff B, Delaney C, Senagore A, Techner L. Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis. World J Surg. 2010;34:2185-90 pubmed publisher
    ..of alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist, for the management of postoperative ileus after bowel resection...
  20. van der Doef H, Slieker M, Staab D, Alizadeh B, Seia M, Colombo C, et al. Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2010;50:347-9 pubmed publisher
    ..acts as a modifier gene in a cohort of 682 European patients with cystic fibrosis (CF)-99 patients with meconium ileus. The 357SS genotype was significantly overrepresented in both patients with meconium ileus and also with a severe ..
  21. Moore B, Manthey C, Johnson D, Bauer A. Matrix metalloproteinase-9 inhibition reduces inflammation and improves motility in murine models of postoperative ileus. Gastroenterology. 2011;141:1283-92, 1292.e1-4 pubmed publisher
    ..Inflammation contributes to development of postoperative ileus (POI), which is caused by physical disturbances to the bowel during abdominal surgery...
  22. Koscielny A, Engel D, Maurer J, Wehner S, Kurts C, Kalff J. The role of lymphoid tissue in the attenuation of the postoperative ileus. Am J Physiol Gastrointest Liver Physiol. 2013;304:G401-12 pubmed publisher
    ..These data demonstrate that secondary lymphoid organs are involved in the propagation of FE and postoperative ileus. FTY720 indirectly affects FE by inhibiting migration of activated T cells from the jejunum and adjacent secondary ..
  23. Choi H, Lee Y, Lee Y, Park J, Min K, Park H. Inflammatory responses in the muscle coat of stomach and small bowel in the postoperative ileus model of guinea pig. Yonsei Med J. 2013;54:1336-41 pubmed publisher
    ..function returns first after surgery, and then the function of the stomach returns to normal after postoperative ileus (POI)...
  24. Zeinali F, Stulberg J, Delaney C. Pharmacological management of postoperative ileus. Can J Surg. 2009;52:153-7 pubmed
    The duration of postoperative ileus following abdominal surgery is quite variable, and prolonged postoperative ileus is an iatrogenic phenomenon with important influence on patient morbidity, hospital costs and length of stay in hospital...
  25. Kronberg U, Kiran R, Soliman M, Hammel J, Galway U, Coffey J, et al. A characterization of factors determining postoperative ileus after laparoscopic colectomy enables the generation of a novel predictive score. Ann Surg. 2011;253:78-81 pubmed publisher
    Postoperative ileus (POI) after colorectal surgery is associated with prolonged hospital stay and increased costs...
  26. Chatterjee S, Chaudhuri T, Ghosh G, Ganguly A. Gallstone ileus--an atypical presentation and unusual location. Int J Surg. 2008;6:e55-6 pubmed publisher
    Gallstone ileus is an uncommon cause of small bowel obstruction and is rarely suspected preoperatively. Patients are usually elderly and present with features of small bowel obstruction...
  27. Asgeirsson T, El Badawi K, Mahmood A, Barletta J, Luchtefeld M, Senagore A. Postoperative ileus: it costs more than you expect. J Am Coll Surg. 2010;210:228-31 pubmed publisher
    The clinical impact of postoperative ileus (POI) after colectomy is difficult to quantify financially because of administrative coding limitations...
  28. Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford A, et al. Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. Hum Genet. 2009;126:763-78 pubmed publisher
    ..Here, we conduct a modifier gene study for meconium ileus (MI), an intestinal obstruction that occurs in 16-20% of CF newborns, providing linkage and association results ..
  29. Braun U, Forster E, Steininger K, Irmer M, Gautschi A, Previtali M, et al. Ultrasonographic findings in 63 cows with haemorrhagic bowel syndrome. Vet Rec. 2010;166:79-81 pubmed publisher
    ..2 per cent) cows. Ultrasonography was considered to be a useful tool for the diagnosis of ileus. However, this imaging modality could be used to make a definitive diagnosis of haemorrhagic bowel syndrome only ..
  30. van der Doef H, Kokke F, Beek F, Woestenenk J, Froeling S, Houwen R. Constipation in pediatric cystic fibrosis patients: an underestimated medical condition. J Cyst Fibros. 2010;9:59-63 pubmed publisher
    ..The aims of this study were to determine prevalence, risk factors and treatment of constipation in patients with Cystic Fibrosis (CF), as well as the diagnostic value of abdominal radiography...
  31. Swenson B, Gottschalk A, Wells L, Rowlingson J, Thompson P, Barclay M, et al. Intravenous lidocaine is as effective as epidural bupivacaine in reducing ileus duration, hospital stay, and pain after open colon resection: a randomized clinical trial. Reg Anesth Pain Med. 2010;35:370-6 pubmed publisher
    Both postoperative epidural analgesia and intravenous (IV) infusion of local anesthetic have been shown to shorten ileus duration and hospital stay after colon surgery when compared with the use of systemic narcotics alone...
  32. Mueller M, Karpitschka M, Gao Z, Mittler S, Kasparek M, Renz B, et al. Vagal innervation and early postoperative ileus in mice. J Gastrointest Surg. 2011;15:891-900; discussion 900-1 pubmed publisher
    Postoperative ileus is characterized by infiltrates of leukocytes in the gut wall 24 h after surgery, which is subject to vagal modulation...
  33. Shang H, Yang Y, Tong X, Zhang L, Fang A, Hong L. Gum chewing slightly enhances early recovery from postoperative ileus after cesarean section: results of a prospective, randomized, controlled trial. Am J Perinatol. 2010;27:387-91 pubmed publisher
    Postoperative ileus is one of the common problems after abdominal surgeries. It contributes to delayed recovery and prolongs hospital stay...
  34. Iyer S, Saunders W, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm. 2009;15:485-94 pubmed
    Postoperative ileus, a transient impairment of gastrointestinal motility, is a common cause of delay in return to normal bowel function after abdominal surgery...
  35. Houwen R, van der Doef H, Sermet I, Munck A, Hauser B, Walkowiak J, et al. Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS. J Pediatr Gastroenterol Nutr. 2010;50:38-42 pubmed publisher
    Various definitions for distal intestinal obstruction syndrome (DIOS), meconium ileus equivalent, and constipation in patients with cystic fibrosis (CF) are used...
  36. Efrati O, Nir J, Fraser D, Cohen Cymberknoh M, Shoseyov D, Vilozni D, et al. Meconium ileus in patients with cystic fibrosis is not a risk factor for clinical deterioration and survival: the Israeli Multicenter Study. J Pediatr Gastroenterol Nutr. 2010;50:173-8 pubmed publisher
    Patients with cystic fibrosis (CF) presenting with meconium ileus (MI) tend to have worse outcomes than those without MI...
  37. Zhou H, Liu L, Bai Y, Wu W, Li G, Li J, et al. Damage of the interstitial cells of Cajal and myenteric neurons causing ileus in acute necrotizing pancreatitis rats. Surgery. 2011;149:262-75 pubmed publisher
    ..role of interstitial cells of Cajal (ICC), myenteric neurons and the associated mechanism in the pathogenesis of ileus during experimentally induced acute pancreatitis...
  38. Gasparrini M, Liverani A, Catracchia V, Conte S, Leonardo G, Marino G, et al. Gallstone ileus: a case report and review of the literature. Chir Ital. 2008;60:755-9 pubmed
    Gallstone ileus is a rare complication of gallstone disease, accounting for 1-4% of all bowel obstructions. The phisiopathology is related to the presence of a bilio-enteric fistula...
  39. Johnson M, Walsh R. Current therapies to shorten postoperative ileus. Cleve Clin J Med. 2009;76:641-8 pubmed publisher
    Postoperative ileus delays hospital discharge, increases costs, and contributes to adverse outcomes. A variety of neural and chemical factors are involved...
  40. Graham J, Rothwell B. Images in clinical medicine. Gallstone ileus. N Engl J Med. 2004;351:1119 pubmed
  41. Mueller M, Glatzle J, Kampitoglou D, Kasparek M, Grundy D, Kreis M. Differential sensitization of afferent neuronal pathways during postoperative ileus in the mouse jejunum. Ann Surg. 2008;247:791-802 pubmed publisher
    Postoperative ileus induces reflex inhibition of gastrointestinal motility and an intestinal inflammatory response...
  42. Quah H, Samad A, Neathey A, Hay D, Maw A. Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial. Colorectal Dis. 2006;8:64-70 pubmed
    Postoperative ileus is common after colorectal resection and can prolong hospital stay. Gum chewing, a type of sham feeding, may to stimulate gut motility via cephalic-vagal stimulation, and thereby reduce the length of ileus...
  43. Schuster R, Grewal N, Greaney G, Waxman K. Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg. 2006;141:174-6 pubmed
    Gum chewing after elective open colon resection may stimulate bowel motility and decrease duration of postoperative ileus. Prospective, randomized study in a community-based teaching hospital...
  44. Zissin R, Osadchy A, Klein E, Konikoff F. Consecutive instances of gallstone ileus due to obstruction first at the ileum and then at the duodenum complicating a gallbladder carcinoma: a case report. Emerg Radiol. 2006;12:108-10 pubmed
    Ectopic gallstone obstruction, gallstone ileus, due to cholecystoenteric fistula is an infrequent condition. Its occurrence as a complication of a gallbladder (GB) carcinoma is even more rare...
  45. Cowles R, Berdon W, Holt P, Buonomo C, Stolar C. Neonatal intestinal obstruction simulating meconium ileus in infants with long-segment intestinal aganglionosis: radiographic findings that prompt the need for rectal biopsy. Pediatr Radiol. 2006;36:133-7 pubmed
    ..intestinal aganglionosis involving the entire colon, ileum and sometimes the jejunum can mimic meconium ileus. This makes the diagnosis difficult for the radiologist and surgeon...
  46. Kirchmayr W, Mühlmann G, Zitt M, Bodner J, Weiss H, Klaus A. Gallstone ileus: rare and still controversial. ANZ J Surg. 2005;75:234-8 pubmed
    Gallstone ileus is a rare disease and accounts for about 1-3% of mechanic ileus of the small bowel, but for 25% of all small bowel obstructions in patients older than 65 years...
  47. Behm B, Stollman N. Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol. 2003;1:71-80 pubmed
    This article will review the pathophysiology of postoperative ileus, with emphasis on potential therapeutic targets, and examine the efficacy of pharmacologic and nonpharmacologic interventions...
  48. Yoshida H, Tajiri T, Mamada Y, Taniai N, Hirakata A, Kawano Y, et al. Diagnosis of gallstone ileus by serial computed tomography. Hepatogastroenterology. 2004;51:33-5 pubmed
    An unusual case of choledocholithiasis followed by gallstone ileus documented by serial computed tomography is reported...
  49. Saclarides T. Current choices--good or bad--for the proactive management of postoperative ileus: A surgeon's view. J Perianesth Nurs. 2006;21:S7-15 pubmed
    Postoperative ileus (POI) is frequently experienced by many patients undergoing abdominal operations and other surgical procedures...
  50. Maruna P, Frasko R, Gurlich R. Plasma procalcitonin in patients with ileus. Relations to other inflammatory parameters. Physiol Res. 2008;57:481-6 pubmed
    ..The purpose of this study was to characterize PCT plasma levels in patients with various types of ileus at preoperative stage, where the other inducing factors such as a surgical stress are excluded...
  51. Noriega Maldonado O, Bernal Mendoza L, Rivera Nava J, Guevara Torres L. [Gallstone ileus]. Cir Cir. 2005;73:443-8 pubmed
    To determine the frequency of gallstone ileus as a cholelithiasis complication and likely cause of intestinal obstruction, as well as the factors that can influence morbidity and mortality of these patients in our hospital...
  52. Lamireau T, Monnereau S, Martin S, Marcotte J, Winnock M, Alvarez F. Epidemiology of liver disease in cystic fibrosis: a longitudinal study. J Hepatol. 2004;41:920-5 pubmed
    ..disease was studied using a multivariate Cox's regression analysis including variables such as history of meconium ileus, pulmonary function, pancreatic insufficiency and CFTR gene mutations...
  53. Saedon M, Gourgiotis S, Salemis N, Majeed A, Zavos A. Gallstone ileus one quarter of a century post cholecystectomy. Ann Hepatol. 2008;7:258-9 pubmed
    Gallstone ileus is a rare but potentially serious complication of cholelithiasis. It is usually preceded by history of biliary symptoms...