duodenal ulcer


Summary: A PEPTIC ULCER located in the DUODENUM.

Top Publications

  1. Ferrer Ferrer M, Malespín Bendaña W, Ramirez V, González M, Carvajal A, Une C. Polymorphisms in genes coding for HSP-70 are associated with gastric cancer and duodenal ulcer in a population at high risk of gastric cancer in Costa Rica. Arch Med Res. 2013;44:467-74 pubmed publisher
    ..with gastric cancer, 79 healthy controls, 55 individuals with chronic gastritis and 52 individuals with duodenal ulcer was genotyped for the polymorphisms HSP70-2 +1267 and HSP70-Hom +2437 by RFLP...
  2. Fakheri H, Taghvaei T, Hosseini V, Bari Z. A comparison between sequential therapy and a modified bismuth-based quadruple therapy for Helicobacter pylori eradication in Iran: a randomized clinical trial. Helicobacter. 2012;17:43-8 pubmed publisher
    ..So we designed a study to compare a sequential regimen with a bismuth-based quadruple therapy that contains a short course of furazolidone, in Iran...
  3. Lario S, Ramírez Lázaro M, Aransay A, Lozano J, Montserrat A, Casalots A, et al. microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population. Clin Microbiol Infect. 2012;18:E273-82 pubmed publisher
    ..The aim was to compare miRNA expression profiling in patients with duodenal ulcer (DU) due to H. pylori infection with that in infected patients without DU and in uninfected patients...
  4. Miyamoto M, Haruma K. [Gastric ulcer and duodenal ulcer]. Nihon Rinsho. 2013;71:1418-23 pubmed
    ..Several reports described occurrence of newly-developed gastric cancer after H. pylori eradication. Careful follow-up upper gastrointestinal endoscopy is necessary after H. pylori eradication. ..
  5. Ceranowicz P, Warzecha Z, Dembinski A, Sendur R, Cieszkowski J, Ceranowicz D, et al. Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats. J Physiol Pharmacol. 2009;60:87-98 pubmed
    ..Treatment with ghrelin accelerates healing of chronic gastroduodenal ulcers and this effect is mediated by the release of endogenous GH and IGF-1. ..
  6. Kumar N, Mukhopadhyay A, Patra R, De R, Baddam R, Shaik S, et al. Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India. J Bacteriol. 2012;194:5963-4 pubmed publisher
    ..pylori genotypes, and this will be helpful in solving the so-called Indian enigma, by which high infection rates do not corroborate the minuscule number of serious outcomes observed, including gastric cancer. ..
  7. Jafarzadeh A, Mirzaee V, Ahmad Beygi H, Nemati M, Rezayati M. Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients. J Dig Dis. 2009;10:107-12 pubmed publisher
    ..study was to investigate the association of the virulence factor CagA with IL-17 and IL-23 serum levels in duodenal ulcer (DU) patients and H. pylori-infected asymptomatic (AS) carriers. In total, 45 H...
  8. Møller M, Adamsen S, Wøjdemann M, Møller A. Perforated peptic ulcer: how to improve outcome?. Scand J Gastroenterol. 2009;44:15-22 pubmed publisher
    ..In order to improve the outcome of patients with peptic ulcer perforation, sepsis needs to be factored into the existing knowledge and treatment. ..
  9. Batista S, Rocha G, Rocha A, Saraiva I, Cabral M, Oliveira R, et al. Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer. BMC Microbiol. 2011;11:61 pubmed publisher
    ..We studied associations between H. pylori CagA EPIYA patterns and gastric cancer and duodenal ulcer, in an ethnically admixed Western population from Brazil...

More Information


  1. Mei Q, Xu J, Cao H, Bao D, Hu N, Zhang L, et al. Associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population. Int J Immunogenet. 2010;37:9-12 pubmed publisher
    ..whether genetic polymorphism of IL-1Beta-511, IL-1RN, TNF-A-308 are involved in the susceptibility to duodenal ulcer (DU)...
  2. Lee N, Yun S, Chae S, Yoo B, Cha S, Kwak B. Perforated duodenal ulcer presenting with massive hematochezia in a 30-month-old child. World J Gastroenterol. 2009;15:4853-5 pubmed
    ..Finally, an exploratory laparotomy was performed. A discrete anterior perforation with active bleeding of the duodenal wall was found. After the operation, there were no complications and the patient recovered fully. ..
  3. Choi K, Kim E, Hong H, Ock C, Lee J, Kim J, et al. Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A2/5-lipoxygenase and activating ?-glutamylcysteine synthetase. J Gastroenterol Hepatol. 2012;27 Suppl 3:13-22 pubmed publisher
    Cysteamine is a reducing aminothiol used for inducing duodenal ulcer through mechanisms of oxidative stress related to thiol-derived H(2)O(2) reaction...
  4. Zhang B, Wang J, Bian D, Chen X. No association between IL-1? -31 C/T polymorphism and the risk of duodenal ulcer: a meta-analysis of 3793 subjects. Hum Immunol. 2012;73:1200-6 pubmed publisher
    ..to perform a meta-analysis to investigate a more authentic association between IL-1? -31 C/T polymorphism and duodenal ulcer (DU). Systematic searches of electronic databases Embase, PubMed and Web of Science were performed...
  5. Sommer T, Elbroend H, Friis Andersen H. Laparoscopic repair of perforated ulcer in Western Denmark - a retrospective study. Scand J Surg. 2010;99:119-21 pubmed
    ..laparoscopic repair of perforated ulcer was done without any selection criteria in few surgical departments in Western Denmark and was associated with a low mortality but a higher risk of reperforation. ..
  6. Bertleff M, Lange J. Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature. Surg Endosc. 2010;24:1231-9 pubmed publisher
    ..A Boey score of 3, age over 70 years, and symptoms persisting longer than 24 h are associated with higher morbidity and mortality and should be considered contraindications for laparoscopic intervention. ..
  7. Wang Y, Richter J, Dempsey D. Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006. Ann Surg. 2010;251:51-8 pubmed publisher
  8. Zhang B, Yin Y, Sun Q. No association between IL-1? -511 C/T polymorphism and the risk of duodenal ulcer: a meta-analysis of 4667 subjects. Gene. 2012;506:188-94 pubmed publisher
    Epidemiological studies have evaluated the association between IL-1? -511 C/T polymorphism and duodenal ulcer (DU) risk. However, the results remain conflicting...
  9. Partida Rodríguez O, Torres J, Flores Luna L, Camorlinga M, Nieves Ramírez M, Lazcano E, et al. Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer. Int J Cancer. 2010;126:1861-1868 pubmed publisher
    ..including 228 with non-atrophic gastritis, 98 with intestinal metaplasia, 63 with gastric cancer and 58 with duodenal ulcer, and 132 asymptomatic individuals as well...
  10. Ramos A, De Fuccio M, Moretzsohn L, Barbosa A, Passos M, Carvalho R, et al. Cystic fibrosis, gastroduodenal inflammation, duodenal ulcer, and H. pylori infection: the "cystic fibrosis paradox" revisited. J Cyst Fibros. 2013;12:377-83 pubmed publisher
    ..19/32 (68%) patients showed positive serology. Endoscopy showed erosive duodenitis (15%), and duodenal ulcer scar in 10%. On duodenal histology, 94.5%, showed active inflammation and 66.7% gastric metaplasia...
  11. Shiwani M, Thornton M. Supradiaphragmatic perforated duodenal ulcer in a giant hiatus hernia. Can J Surg. 2008;51:E89-90 pubmed
  12. Romo González C, Salama N, Burgeño Ferreira J, Ponce Castaneda V, Lazcano Ponce E, Camorlinga Ponce M, et al. Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes. Infect Immun. 2009;77:2201-11 pubmed publisher
    ..H. pylori isolates from 10 patients with nonatrophic gastritis, 10 patients with duodenal ulcer, and 9 patients with gastric cancer were studied...
  13. Zhang Z, Zheng Q, Chen X, Xiao S, Liu W, Lu H. The Helicobacter pylori duodenal ulcer promoting gene, dupA in China. BMC Gastroenterol. 2008;8:49 pubmed publisher
    The prevalence of H. pylori is as high as 60-70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by H. pylori, they are at opposite ends of the spectrum and as such are considered mutually exclusive...
  14. Zub Pokrowiecka A, Rembiasz K, Konturek S, Budzynski A, Konturek P, Budzynski P. Ghrelin in diseases of the gastric mucosa associated with Helicobacter pylori infection. Med Sci Monit. 2010;16:CR493-500 pubmed
    ..pylori in the stomach with peptic ulcer increases plasma ghrelin levels, whereas in gastric cancer and atrophic gastritis it is accompanied by a marked decrease in plasma and cancer tissue levels of ghrelin. ..
  15. Alam J, Maiti S, Ghosh P, De R, Chowdhury A, Das S, et al. Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population. J Med Microbiol. 2012;61:1295-302 pubmed publisher
    A novel virulence factor, duodenal ulcer-promoting gene A (dupA), in Helicobacter pylori has been found to be associated with disease in certain populations but not in others...
  16. Gisbert J, Calvet X. Review article: Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther. 2009;30:791-815 pubmed publisher
    Helicobacter pylori infection rates in duodenal ulcer (DU) patients may be lower than previously estimated. To review the real prevalence of H. pylori-negative DUs and its possible causes...
  17. Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson G, McLaren G. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1277-86 pubmed publisher
  18. Tanikawa C, Urabe Y, Matsuo K, Kubo M, Takahashi A, Ito H, et al. A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet. 2012;44:430-4, S1-2 pubmed publisher
    Through a genome-wide association analysis with a total of 7,035 individuals with duodenal ulcer and 25,323 controls from Japan, we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at ..
  19. Saha D, Datta S, Chattopadhyay S, Patra R, De R, Rajendran K, et al. Indistinguishable cellular changes in gastric mucosa between Helicobacter pylori infected asymptomatic tribal and duodenal ulcer patients. World J Gastroenterol. 2009;15:1105-12 pubmed
    ..parameters occurring in the stomach tissue of Helicobacter pylori (H pylori) infected tribal populations and duodenal ulcer patients among ethnic Bengalis and correlation of the genotypes of H pylori with different histological ..
  20. Moura S, Almeida L, Guerra J, Rocha G, Camargos Rocha A, Melo F, et al. Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. Microbes Infect. 2008;10:1477-83 pubmed publisher
    ..pylori susceptibility and risk for duodenal ulcer in children. Gastric biopsy specimens were obtained at endoscopy for evaluation of H...
  21. Lee J, Sung K, Lee D, Lee W, Kim W. Single-port laparoscopic repair of a perforated duodenal ulcer: intracorporeal "cross and twine" knotting. Surg Endosc. 2011;25:229-33 pubmed publisher
    ..of our simple "cross and twine" intracorporeal knotting approach for treatment of a perforated duodenal ulcer. From January 2009 to October 2009, 13 patients with perforated duodenal ulcers underwent single-port ..
  22. Sarkar S, Buha D. Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats. Indian J Exp Biol. 2008;46:639-45 pubmed
    ..pepo fruit pulp extract for 14 consecutive days showed increase in AP activity and mucosal thickness along with decrease in UI, suggesting gastroduodenal protective and anti-ulcerogenic properties of C. pepo...
  23. Nuhu A, Madziga A, Gali B. Acute perforated duodenal ulcer in Maiduguri: experience with simple closure and Helicobacter pylori eradication. West Afr J Med. 2009;28:384-7 pubmed
    ..There is a changing trend in emergency surgery for perforated duodenal ulcer (PDU) from definitive anti ulcer surgery to simple closure followed by Helicobacter pylori eradication...
  24. Yang Y, Sheu B, Chang W, Cheng H, Yang H. Increased body mass index after H. pylori eradication for duodenal ulcer predisposes to erosive reflux esophagitis. J Clin Gastroenterol. 2009;43:705-10 pubmed publisher
    ..The study aimed to determine whether increased BMI after H. pylori eradication in duodenal ulcer patients predisposes to erosive reflux esophagitis...
  25. Khoder G, Yamaoka Y, Fauchère J, Burucoa C, Atanassov C. Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:1193-9 pubmed publisher
    Protein patterns of 129 Helicobacter pylori strains isolated from Korean and Colombian patients suffering from duodenal ulcer or gastric cancer were analyzed by the high-throughput methodology SELDI-TOF-MS...
  26. Lal P, Vindal A, Hadke N. Controlled tube duodenostomy in the management of giant duodenal ulcer perforation: a new technique for a surgically challenging condition. Am J Surg. 2009;198:319-23 pubmed publisher
    Giant duodenal ulcer (GDU) perforation remains an extremely uncommon but a rather challenging condition to manage wherein routine surgical procedures are fraught with an extremely high incidence of failure and mortality...
  27. Sugano K, Matsumoto Y, Itabashi T, Abe S, Sakaki N, Ashida K, et al. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. J Gastroenterol. 2011;46:724-35 pubmed publisher
    ..042-0.230). Lansoprazole was superior to gefarnate in reducing the risk of gastric or duodenal ulcer recurrence in patients with a definite history of gastric or duodenal ulcers who required long-term LDA ..
  28. Shimamoto T, Yamamichi N, Kodashima S, Takahashi Y, Fujishiro M, Oka M, et al. No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan. PLoS ONE. 2013;8:e65996 pubmed publisher
    ..aim is to evaluate the effect of coffee consumption on four major acid-related diseases: gastric ulcer (GU), duodenal ulcer (DU), reflux esophagitis (RE), and non-erosive reflux disease (NERD) based on the large-scale multivariate ..
  29. Saccomani G, Percivale A, Stella M, Durante V, Pellicci R. Laparoscopic billroth II gastrectomy for completely stricturing duodenal ulcer: technical details. Scand J Surg. 2003;92:200-2 pubmed
    ..of three patients who underwent laparoscopic gastrectomy for gastric outlet obstruction due to stricturing duodenal ulcer. In all cases an intracorporeal resection of the antrum and an antecolic end to side gastrojejunostomy (..
  30. Olfat F, Zheng Q, Oleastro M, Voland P, Boren T, Karttunen R, et al. Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. FEMS Immunol Med Microbiol. 2005;44:151-6 pubmed
    ..This finding appears to reflect allelic variations of the babA2 gene in SWE, although adhesive properties of the strains are retained. ..
  31. Radziejewska I, Kisiel D, Borzym Kluczyk M, Kluz A, Namiot Z, Gindzienski A. MUC 1 mucin content in gastric juice of duodenal ulcer patients: effect of Helicobacter pylori eradication therapy. Clin Exp Med. 2007;7:72-6 pubmed
    ..Gastric juice samples of 14 duodenal ulcer patients infected with H. pylori were assayed before and at the end of eradication...
  32. Sung H, Kim J, Park Y, Cheung D, Cho S, Park S, et al. The papilla of Vater just below the pylorus presenting as recurrent duodenal ulcer bleeding. Intern Med. 2007;46:1853-6 pubmed
    ..We report here a case with recurrent duodenal ulcer bleeding associated with this anomaly. A 42-year-old man was admitted to St...
  33. Choi K, Kim N, Lee D, Kim J, Kim J, Jung H, et al. Analysis of the 3' variable region of the cagA gene of Helicobacter pylori isolated in Koreans. Dig Dis Sci. 2007;52:960-6 pubmed
    ..Seventy-nine patients (chronic gastritis, 15; duodenal ulcer, 27; benign gastric ulcer, 18; gastric cancer, 19) were enrolled...
  34. Namiot Z, Namiot D, Kemona A, Stasiewicz J. Effect of antibacterial therapy and salivary secretion on the efficacy of Helicobacter pylori eradication in duodenal ulcer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:714-7 pubmed
    ..The study involved 90 H pylori-positive subjects with duodenal ulcer (68 men, 22 women, aged 20-70 years) in whom saliva was collected under basal conditions for 45 min before ..
  35. López Cepero J, López Silva M, Amaya Vidal A, Alcaraz García S, Cayón Blanco M, Castro T, et al. [Influence of climatic factors on the incidence of upper gastrointestinal bleeding]. Gastroenterol Hepatol. 2005;28:540-5 pubmed
    ..role of these factors in the incidence of UGB secondary to esophageal varices (EV), gastric ulcer (GU), and duodenal ulcer (DU)...
  36. Alvarado Aparicio H, Moreno Portillo M. Multimedia article: management of duodenal ulcer perforation with combined laparoscopic and endoscopic methods. Surg Endosc. 2004;18:1394 pubmed
    In the past, primary closes for perforated duodenal ulcer were not effective because of the high incidence of recurrence (42%), therefore most surgeons preferred definitive procedures to control acid production...
  37. Lee S, Kim B, Choi W, Lee I, Choi J, Song K. Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B -31 C/+ and IL-1RN *2/*2) and gastric cancer/duodenal ulcer in Korean population. Cytokine. 2003;21:167-71 pubmed
    ..We tested the association between the polymorphisms and 190 gastric cancer, 117 duodenal ulcer, and 172 healthy subjects as controls in the Korean population...
  38. Lu H, Hsu P, Graham D, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology. 2005;128:833-48 pubmed
    ..We examined 500 H pylori strains from East Asia and South America, including 120 with gastritis, 140 with duodenal ulcer (DU), 110 with gastric ulcer (GU), and 130 with gastric cancer...
  39. Argent R, Burette A, Miendje Deyi V, Atherton J. The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis. 2007;45:1204-6 pubmed
    ..We determined the prevalence of dupA in H. pylori strains recovered from 4 independent populations and found a significant association with gastric cancer but not with duodenal ulceration. ..
  40. Jin L, Yoshida M, Nakamura T, Ishikawa H, Wakabayashi G, Tanabe M, et al. Candida albicans infection delays duodenal ulcer healing in cysteamine-induced duodenal ulcers in rats. Dig Dis Sci. 2008;53:2878-85 pubmed publisher
    ..group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (..
  41. Zambon C, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine. 2005;29:141-52 pubmed
    ..cagA, s1 and m1 vacA, were PCR amplified. Duodenal ulcer was more frequent in TNF-A -857 TT and in IL-1RN 1,2 subjects...
  42. Kim N, Cho S, Yim J, Kim J, Lee D, Park J, et al. The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea. Helicobacter. 2006;11:105-12 pubmed
    ..of 1360 subjects: control, gastric cancer (GC, intestinal type, and diffuse type), benign gastric ulcer (BGU), duodenal ulcer, and first-degree gastric cancer relative (GCR)...
  43. Queiroz D, Bittencourt P, Guerra J, Rocha A, Rocha G, Carvalho A. IL1RN polymorphism and cagA-positive Helicobacter pylori strains increase the risk of duodenal ulcer in children. Pediatr Res. 2005;58:892-6 pubmed
    ..authors evaluated the role of proinflammatory interleukin-1 gene cluster polymorphisms in the pathogenesis of duodenal ulcer. They studied prospectively 437 children 1 to years old, 209 of whom were H...
  44. Nilsson C, Sillén A, Eriksson L, Strand M, Enroth H, Normark S, et al. Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease. Infect Immun. 2003;71:6573-81 pubmed
    ..We have analyzed the composition of the cag PAI in 66 clinical isolates obtained from patients with duodenal ulcer, gastric cancer, and nonulcer dyspepsia...
  45. Bardhan K, Royston C. Time, change and peptic ulcer disease in Rotherham, UK. Dig Liver Dis. 2008;40:540-6 pubmed publisher
    ..Seven thousand five hundred and ninety new peptic ulcer disease patients (5564 duodenal ulcer+2026 gastric ulcer) were seen, peaking in 1982-1986 but declining thereafter, and with a falling male ..
  46. Lunevicius R, Morkevicius M. Management strategies, early results, benefits, and risk factors of laparoscopic repair of perforated peptic ulcer. World J Surg. 2005;29:1299-310 pubmed
    The primary goal of this study was to describe epidemiology and management strategies of the perforated duodenal ulcer, as well as the most common methods of laparoscopic perforated duodenal ulcer repair...
  47. Song K, Kim T, Kim S, Park C. Laparoscopic repair of perforated duodenal ulcers: the simple "one-stitch" suture with omental patch technique. Surg Endosc. 2008;22:1632-5 pubmed
    ..simple "one-stitch" suture with omental patch technique for treating 35 patients with perforated duodenal ulcer. The laparoscopic treatment included peritoneal lavage, suture of the perforation without knotting, and then ..
  48. Zapata Colindres J, Zepeda Gomez S, Montano Loza A, Vázquez Ballesteros E, de Jesús Villalobos J, Valdovinos Andraca F. The association of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic ulcer disease. Can J Gastroenterol. 2006;20:277-80 pubmed
    ..001). The development of PUD was observed earlier in the combined H pylori and NSAID group than in patients with only NSAID use. This suggests a synergic effect between the two risks factors in the development of PUD. ..
  49. Erzin Y, Koksal V, Altun S, Dobrucali A, Aslan M, Erdamar S, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia. Helicobacter. 2006;11:574-80 pubmed
    ..Ninety-three H. pylori-positive patients [30 with non-ulcer dyspepsia (NUD), 30 with duodenal ulcer (DU), and 33 with gastric cancer (GC)] who were admitted to our endoscopy unit due to dyspepsia were enrolled ..
  50. Garcia Rodriguez L, Barreales Tolosa L. Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology. 2007;132:498-506 pubmed
    ..Whether use of selective inhibitors of cyclooxygenase-2 (COXIBs) will translate into a clinically relevant reduced toxicity has not been widely investigated in the general population...
  51. Povoski S, Shamma a J. Fistula involving portal vein and duodenum at the site of a duodenal ulcer in a patient after previous extrahepatic bile duct resection and brachytherapy. Dig Surg. 2003;20:53-5 pubmed
    ..A case of a fistula between the main portal vein and the posterior wall of the duodenal bulb at the site of a duodenal ulcer in a patient who had previously undergone an extrahepatic bile duct resection and brachytherapy for mucinous ..
  52. Arachchi H, Kalra V, Lal B, Bhatia V, Baba C, Chakravarthy S, et al. Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter. 2007;12:591-7 pubmed
    The duodenal ulcer (DU)-promoting gene (dupA) of Helicobacter pylori has been identified as a novel virulent marker associated with an increased risk for DU. The presence or absence of dupA gene of H...
  53. Paul Jayaraj A, Tovey F, Hobsley M. Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids. Phytother Res. 2003;17:391-8 pubmed
    ..sterol esters and phospholipids in the lipid fraction of foods in staple diets may account for the low prevalence of duodenal ulcer in certain geographical areas, despite a uniformly high prevalence of Helicobacter pylori infection.