Summary: Inflammation of the RECTUM and the distal portion of the COLON.

Top Publications

  1. Kiely E, Ajayi N, Wheeler R, Malone M. Diversion procto-colitis: response to treatment with short-chain fatty acids. J Pediatr Surg. 2001;36:1514-7 pubmed
    ..Histopathology provides supportive evidence and SCFAs may provide effective relief of symptoms. Stoma reversal or rectal excision is curative. ..
  2. Andersson P, Olaison G, Bendtsen P, Myrelid P, Sjodahl R. Health related quality of life in Crohn's proctocolitis does not differ from a general population when in remission. Colorectal Dis. 2003;5:56-62 pubmed
    ..this study was to compare health-related quality of life and psychosocial conditions in patients with Crohn's proctocolitis with a general population...
  3. Godart B, Beau P, Benchellal Z, Bumsel F, Metman E. [Ulcerative colitis associated with rectocolitis hemorrhagic: successful treatment with infliximab]. Gastroenterol Clin Biol. 2007;31:88-90 pubmed
  4. Lemann M. [Treatment of chronic inflammatory bowel diseases]. Bull Acad Natl Med. 2007;191:1125-41; discussion 1141 pubmed
    ..The choice of maintenance therapy depends on the nature of the disease (HRC or CD) and its progressive nature. Surgery is reserved for patients with complicated and drug-resistant forms. ..
  5. Troncone R, Discepolo V. Colon in food allergy. J Pediatr Gastroenterol Nutr. 2009;48 Suppl 2:S89-91 pubmed publisher
    The colon is a site of allergic reaction to food proteins. The most common manifestation is allergic proctocolitis. Although frequent in infancy, it may also affect older children...
  6. Desoubeaux G, Gaillard J, Borée Moreau D, Bailly E, Andres C, Chandenier J. Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax. Pathog Glob Health. 2014;108:158-63 pubmed publisher
    ..The definite identification of the E. tenax species was made possible by scanning electron microscopy. The clinical outcome was satisfactory. ..
  7. Fofi C, Nicoletti M, Onetti Muda A, Giulio S. [Focal segmental glomerulosclerosis with IgA deposits in a patient with ulcerative colitis]. G Ital Nefrol. 2003;20:641-4 pubmed
    ..Mesangial IgA deposits could be an "occasional" further occurrence, considering the chronic inflammation of colonic mucosa and the altered immune response of patients with UC. ..
  8. Delaini G, Scaglia M, Lindholm E, Colucci G, Hulten L. Is an ileal pouch an alternative for patients requiring surgery for Crohn's proctocolitis?. Tech Coloproctol. 2005;9:222-4 pubmed
    ..The possibility of having a continent ileostomy, thereby avoiding a conventional ileostomy-even if only for a limited number of years--may be an attractive option for young, highly motivated patients. ..
  9. Kono T, Nomura M, Kasai S, Kohgo Y. Effect of ecabet sodium enema on mildly to moderately active ulcerative proctosigmoiditis: an open-label study. Am J Gastroenterol. 2001;96:793-7 pubmed
    ..The ES enemas proved to be a safe and potentially useful adjuvant therapy currently available for treating patients with mildly to moderately active ulcerative proctosigmoiditis. A controlled study is necessary to confirm our results. ..

More Information


  1. Greenhawt M, Bird J, Nowak Węgrzyn A. Trends in Provider Management of Patients with Food Protein-Induced Enterocolitis Syndrome. J Allergy Clin Immunol Pract. 2017;5:1319-1324.e12 pubmed publisher
    ..FPIES was correctly differentiated from infantile colic or food protein-induced allergic proctocolitis by 82.5% and 71.3%, respectively. Among providers currently managing patients with FPIES, 47...
  2. Zoungrana S, Angeli K, Schneider S, Saint Paul M, Filippi J, Hebuterne X. [Secondary rectal syphilis revealed by a dysentery-like syndrome]. Gastroenterol Clin Biol. 2008;32:167-9 pubmed
  3. Nacaroglu H, Bahceci Erdem S, Durgun E, Karaman S, Baris Erdur C, Unsal Karkmer C, et al. Markers of inflammation and tolerance development in allergic proctocolitis. Arch Argent Pediatr. 2018;116:e1-e7 pubmed publisher
    Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive ..
  4. Almallah Y, Ewen S, El Tahir A, Mowat N, Brunt P, Sinclair T, et al. Distal proctocolitis and n-3 polyunsaturated fatty acids (n-3 PUFAs): the mucosal effect in situ. J Clin Immunol. 2000;20:68-76 pubmed
    ..The aim of this study, therefore, was to evaluate the in situ effect of n-3 PUFAs on distal proctocolitis. Each patient received either fish oil extract (EPA 3.2 g, DHA 2...
  5. Hwang J, Park M, Kang Y, Kim S, Suh S, Kam S. Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis. J Korean Med Sci. 2007;22:213-7 pubmed
    The clinicopathological findings in previous studies concerning food protein-induced proctocolitis (FPIPC) are quite diverse in terms of results and conclusions...
  6. Holt P, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005;50:2191-3 pubmed
    ..This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies. ..
  7. Loriot Y, Boudou Rouquette P, Billemont B, Ropert S, Goldwasser F. Acute exacerbation of hemorrhagic rectocolitis during antiangiogenic therapy with sunitinib and sorafenib. Ann Oncol. 2008;19:1975 pubmed publisher
  8. Köksal B, Baris Z, Ozcay F, Yilmaz Ozbek O. Single and multiple food allergies in infants with proctocolitis. Allergol Immunopathol (Madr). 2018;46:3-8 pubmed publisher
    Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined...
  9. Regueiro M. Diagnosis and treatment of ulcerative proctitis. J Clin Gastroenterol. 2004;38:733-40 pubmed
    ..This review highlights the pathogenesis, diagnosis, and treatment of ulcerative proctitis. ..
  10. Shih H, Wu D, Huang W, Chang Y, Yu F. Glutaraldehyde-induced colitis: case reports and literature review. Kaohsiung J Med Sci. 2011;27:577-80 pubmed publisher
    ..Conservative treatment, including bowel rest and parenteral hydration, is able to stabilize the condition in a week. Herein, we present two cases of acute proctocolitis caused by glutaraldehyde after uneventful colonoscopy.
  11. Kimura M, Shimomura M, Morishita H, Meguro T, Seto S. Eosinophilia in infants with food protein-induced enterocolitis syndrome in Japan. Allergol Int. 2017;66:310-316 pubmed publisher
    ..syndrome (FPIES) show eosinophilia, which has been thought to be a characteristic of food protein-induced proctocolitis (FPIP)...
  12. Camargo L, Silveira J, Taddei J, Fagundes U. ALLERGIC PROCTOCOLITIS IN INFANTS: analysis of the evolution of the nutritional status. Arq Gastroenterol. 2016;53:262-266 pubmed publisher
    Allergic proctocolitis is a disease that affects infants in the first months. The change in feed is the primary factor for clinical improvement and maintenance of the nutritional status of the infant...
  13. Jang H, Kim A, Hwang J. The etiology of small and fresh rectal bleeding in not-sick neonates: should we initially suspect food protein-induced proctocolitis?. Eur J Pediatr. 2012;171:1845-9 pubmed publisher
    This study was performed to identify the cause and frequency of food protein-induced proctocolitis (FPIPC) in not-sick neonates with small and fresh rectal bleeding and to verify the effectiveness of oral food elimination and challenge ..
  14. Nevoral J, Rada V, Vlkova E, Blahova K, Bronsky J, Bubáková D, et al. Intestinal microbiota in exclusively breast-fed infants with blood-streaked stools. Folia Microbiol (Praha). 2009;54:167-71 pubmed publisher
    ..pANCA positivity was found in 53 % of patients. In conclusion a significant low proportion of bifidobacterial microbiota in patients with blood-streaked stools was shown in comparison with controls. ..
  15. Bone J, Claver A, Guallar I, Plaza A. Allergic proctocolitis, food-induced enterocolitis: immune mechanisms, diagnosis and treatment. Allergol Immunopathol (Madr). 2009;37:36-42 pubmed
    ..The gastrointestinal problems derived from these delayed or chronic reactions comprise allergic proctocolitis, enterocolitis and food protein enteropathies...
  16. Ducou Le Pointe H. [Inflammatory digestive pathology: indications for computed tomography]. JBR-BTR. 2005;88:264-5 pubmed
  17. Laureyns J, Pardon B, Letellier C, Deprez P. Periparturient infection with bovine viral diarrhea virus type 1 causes hemorrhagic proctocolitis in a cow. Can Vet J. 2011;52:1135-9 pubmed
    ..Blood analyses revealed the complete absence of white blood cells, the presence of a type 1b strain of bovine viral diarrhea virus (BVDV), and seroconversion to BVDV. ..
  18. Elloumi H, Ben Abdelaziz A, Arfaoui D, Lassoued Y, Letaief R, Jmaa A, et al. [Predictive factors of recurrence after surgery in severe attacks of hemorrhagic ulcerative proctocolitis]. Tunis Med. 2007;85:417-20 pubmed
    ..Bowel movements/day over 7 on day 3 of hospitalization was the only independently predictive factor of surgery after glucortico steroid treatment failure ..
  19. Hill K, Huang H, Katon R. Acute proctosigmoiditis caused by a dexamethasone mouthwash enema. Gastrointest Endosc. 2005;61:612-4 pubmed
  20. Comberiati P, Landi M, Martelli A, Piacentini G, Capristo C, Paiola G, et al. Awareness of allergic enterocolitis among primary-care paediatricians: A web-based pilot survey. Allergol Immunopathol (Madr). 2016;44:461-6 pubmed publisher
    ..1% recognised acute FPIES and 12.9% recognised all chronic FPIES, whereas 10.3% misdiagnosed FPIES as allergic proctocolitis or infantile colic. To diagnose FPIES 55...
  21. Ionescu M, Dumitrascu T, Stroescu C, Barbuţă S, Tomulescu V, Popescu I. [Surgical treatment in ulcerative rectocolitis . Analysis of a 24 years experience of 50 patients]. Chirurgia (Bucur). 2004;99:125-35 pubmed
    ..The global mortality rate was 12% (6 patients). ..
  22. Lim G, Roslani A, Pang B, Bih Shiou C. Cholesterol atheroembolism of the colon can mimic the endoscopic features of pseudomembranous colitis. Surg Laparosc Endosc Percutan Tech. 2008;18:616-8 pubmed publisher
    ..Histology revealed cholesterol atheroembolism resulting in patchy ischemic ulceration of the colon. Colonic cholesterol atheroembolism can mimic the endoscopic features of pseudomembranous colitis. ..
  23. Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K. Gastrointestinal food allergy in infants. Allergol Int. 2013;62:297-307 pubmed publisher
    ..of different clinical entities: food protein-induced enterocolitis syndrome (FPIES), food protein-induced proctocolitis (FPIP), food protein-induced enteropathy (Enteropathy) and eosinophilic gastrointestinal disorders (EGID)...
  24. Hsu C, Wang J, Kung Y, Chang M. What is the predictor of surgical mortality in adult colorectal perforation? The clinical characteristics and results of a multivariate logistic regression analysis. Surg Today. 2017;47:683-689 pubmed publisher
    ..2 %). The highest etiology-specific mortality was for colorectal cancer (61.5 %) and ischemic proctocolitis (59.8 %)...
  25. Fekih M, Ben Hlima S, Zitouni M, Matri S, Boubaker J, Makni S, et al. [Interest of serologic markers in inflammatory bowel disease. About 105 cases]. Tunis Med. 2007;85:821-8 pubmed
    ..The ASCA and pANCA are useful during some clinical situations such as differentiation between IBD otherss colitis and to distinguish CD from UC. ..
  26. Dumortier J, Scoazec J, Fouque P, Pujol B, Boillot O. [Colonic lymphoma complicating hemorrhagic rectocolitis after liver transplantation]. Gastroenterol Clin Biol. 2003;27:833-4 pubmed
  27. Williams D, Churchill D. Ulcerative proctitis in men who have sex with men: an emerging outbreak. BMJ. 2006;332:99-100 pubmed
  28. Bernardeau Mozer M, Chaussade S. [Cyclooxygenase 2 inhibitors and colorectal cancer]. Bull Cancer. 2004;91 Suppl 2:S89-98 pubmed
    ..This work although review clinicals data of their efficacy as chemopreventive agent as well as therapeutic in the differents group at risk for colorectal cancer. ..
  29. Chiang C, Lee C, Huang C, Huang S, Wu C. A rare cause of ischemic proctosigmoiditis: idiopathic myointimal hyperplasia of mesenteric veins. Endoscopy. 2012;44 Suppl 2 UCTN:E54-5 pubmed publisher
  30. Sahin P, Pozsár J, Simon K, Illyes G, Laszlo F, Topa L. Autoimmune pancreatitis associated with immune-mediated inflammation of the papilla of Vater: report on two cases. Pancreas. 2004;29:162-6 pubmed
    ..The immunohistological features of endoscopic biopsy samples from the swollen MDP were identical as in the surgically resected specimens. Immune-mediated inflammation of the MDP may be associated with AIP. ..
  31. Heine R. Pathophysiology, diagnosis and treatment of food protein-induced gastrointestinal diseases. Curr Opin Allergy Clin Immunol. 2004;4:221-9 pubmed
    ..Clinical presentations include protein-induced enterocolitis syndrome, enteropathy and proctocolitis, as well as eosinophilic gastroenteritis and related disorders...
  32. Ehman E, Phelps A, Ohliger M, Rhee S, MacKenzie J, Courtier J. Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation. Clin Imaging. 2016;40:1135-1139 pubmed publisher
    ..45-0.73. Interobserver agreement was ?=0.53 for DWI/T2 and ?=0.63 for postcontrast images. DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/interobserver reliability. ..
  33. Ishihara S, Watanabe T, Nagawa H. Free colonic perforation in a patient with Crohn's disease and loop ileostomy: report of a case. Int Surg. 2011;96:159-61 pubmed
    ..However, in some cases, fecal diversion is reported to adversely affect the inflammation of the diverted bowel, and it is this unusual complication of Crohn's disease that we discuss here. ..
  34. Hsu C, Lin C, Wang J, Wang H, Ou W, King T. Acute rectocolitis following endoscopy in health check-up patients--glutaraldehyde colitis or ischemic colitis?. Int J Colorectal Dis. 2009;24:1193-200 pubmed publisher
  35. Anzai H, Hata K, Kishikawa J, Ishii H, Nishikawa T, Tanaka T, et al. Clinical pattern and progression of ulcerative proctitis in the Japanese population: a retrospective study of incidence and risk factors influencing progression. Colorectal Dis. 2016;18:O97-O102 pubmed publisher
    ..A younger age of disease onset was associated with disease extension. Extension of proctitis may be associated with an increased risk of colorectal cancer. ..
  36. DOLCE P, Gourdeau M, April N, Bernard P. Outbreak of glutaraldehyde-induced proctocolitis. Am J Infect Control. 1995;23:34-9 pubmed
    An outbreak of hemorrhagic proctocolitis occurred after the introduction of 2% glutaraldehyde as a disinfectant for colonoscopes. An inadequate rinsing procedure was detected...
  37. Coulie B, Camilleri M, Bharucha A, Sandborn W, Burton D. Colonic motility in chronic ulcerative proctosigmoiditis and the effects of nicotine on colonic motility in patients and healthy subjects. Aliment Pharmacol Ther. 2001;15:653-63 pubmed
    ..Nicotine has dose-dependent effects on colonic motor activity in healthy subjects. ..
  38. Pal K, Tinalal S, Al Buainain H, Singh V. Diversion proctocolitis and response to treatment with short-chain fatty acids--a clinicopathological study in children. Indian J Gastroenterol. 2015;34:292-9 pubmed publisher
    Diversion proctocolitis (DPC) frequently develops in the colorectum after diversion of the fecal stream characterized by bleeding from the inflamed mucosa...
  39. Mylonakis E, Allan R, Keighley M. How does pouch construction for a final diagnosis of Crohn's disease compare with ileoproctostomy for established Crohn's proctocolitis?. Dis Colon Rectum. 2001;44:1137-42; discussion 1142-3 pubmed
    ..Nevertheless, the functional results of those with a successful outcome are comparable. ..
  40. Chalumeau S, Moussata D, Nancey S, Claudel Bonvoisin S, Saurin J, Flourie B. [Pancytopenia induced by two low-dose injections of methotrexate in a patient treated for ulcerative colitis]. Gastroenterol Clin Biol. 2007;31:1104-6 pubmed
    ..This report emphasizes the need for a close monitoring of hematologic tests after onset of methotrexate particularly if some risk factors are present. ..
  41. Gallegos M, Bradly D, Jakate S, Keshavarzian A. Lymphogranuloma venereum proctosigmoiditis is a mimicker of inflammatory bowel disease. World J Gastroenterol. 2012;18:3317-21 pubmed publisher
    ..We describe three such cases initially suspected to be an inflammatory bowel disease and subsequently identified as C. trachomatis proctosigmoiditis. ..
  42. Kumagai H, Maisawa S, Tanaka M, Takahashi M, Takasago Y, Nishijima A, et al. Intestinal microbiota and secretory immunoglobulin A in feces of exclusively breast-fed infants with blood-streaked stools. Microbiol Immunol. 2012;56:657-63 pubmed publisher
    ..Such bleeding is thought to be associated with food protein-induced proctocolitis, however the pathomechanism remains unclear...
  43. Martin Iguacel R, Llibre J, Nielsen H, Heras E, Matas L, Lugo R, et al. Lymphogranuloma venereum proctocolitis: a silent endemic disease in men who have sex with men in industrialised countries. Eur J Clin Microbiol Infect Dis. 2010;29:917-25 pubmed publisher
    ..It has additional public health implications since LGV may facilitate the transmission and acquisition of HIV and other STD. ..
  44. Echenique I, García Gonzrález J, Echenique I, Izquierdo N, Mella J, Barasorda E, et al. Hermansky Pudlak syndrome: an unusual form of procto-colitis. Bol Asoc Med P R. 2008;100:76-9 pubmed
    ..Furthermore, avoidance of a perineal wound is preferred, and when possible, ileostomies have fewer complications than colostomies as they do not involve the small bowel. ..
  45. Comar M, Delbue S, Lepore L, Martelossi S, Radillo O, Ronfani L, et al. Latent viral infections in young patients with inflammatory diseases treated with biological agents: prevalence of JC virus genotype 2. J Med Virol. 2013;85:716-22 pubmed publisher
    ..Conversely, increased susceptibility to herpesviruses infection was not shown. Future studies are warranted to investigate the effects of JCV reactivation on the health of young patients treated with infliximab...
  46. Zhang F, Zhong X, Miao L, Liu Z, Huang G, Wu P, et al. High concentration glutaraldehyde-induced severe procto-sigmoiditis: treatment experiences and the 20-month follow-up. Dig Liver Dis. 2008;40:483-4 pubmed publisher
  47. Kuipers T, Hoekstra C, van t Riet A, Mak A, Vonk E, Elders L, et al. HDR brachytherapy applied to cervical carcinoma with moderate lateral expansion: modified principles of treatment. Radiother Oncol. 2001;58:25-30 pubmed
    ..The 3-year disease-free survival in stage IIB patients and the low complication rates in all stages together, justify its continuation. ..
  48. Leonard S. Non-IgE-mediated Adverse Food Reactions. Curr Allergy Asthma Rep. 2017;17:84 pubmed publisher allergies: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE)...
  49. Wardle T, Hall L, Turnberg L. Use of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease. Gut. 1992;33:1644-51 pubmed
  50. Macaigne G, Auriault M, Boivin J, Chayette C, Cheaib S, Deplus R. [Acute cytomegalovirus (CMV) recto-colitis mimicking rectal carcinoma without apparent cause of immunodeficiency]. Gastroenterol Clin Biol. 2004;28:73-6 pubmed
    ..In the absence of controlled data in the field of CMV intestinal infections in immunocompetents, we discuss the potential benefit of an antiviral therapy in those patients who do not recover rapidly and spontaneously. ..
  51. Gionchetti P, Rizzello F, Morselli C, Campieri M. Review article: problematic proctitis and distal colitis. Aliment Pharmacol Ther. 2004;20 Suppl 4:93-6 pubmed
    ..Surgical colectomy may be required in those rare patients refractory or intolerant to pharmacotherapy. ..
  52. Kimura M, Shimomura M, Morishita H, Meguro T, Seto S. Serum C-reactive protein in food protein-induced enterocolitis syndrome versus food protein-induced proctocolitis in Japan. Pediatr Int. 2016;58:836-41 pubmed publisher clarify and compare the incidence of this in patients with FPIES versus patients with food protein-induced proctocolitis (FPIP)...
  53. Nishii S, Higashiyama M, Ogata S, Komoto S, Ito S, Mizoguchi A, et al. Human intestinal spirochetosis mimicking ulcerative colitis. Clin J Gastroenterol. 2018;11:145-149 pubmed publisher
    ..This case reveals (1) a possible pro-inflammatory role of HIS, (2) difficulties in diagnosing HIS in chronic proctocolitis, and (3) a possible inclusion of some HIS cases in "UC"...