sphincter of oddi

Summary

Summary: The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.

Top Publications

  1. Khashab M, Watkins J, McHenry L, Lazzell Pannell L, Schmidt S, Sherman S, et al. Frequency of sphincter of Oddi dysfunction in patients with previously normal sphincter of Oddi manometry studies. Endoscopy. 2010;42:369-74 pubmed publisher
    b>Sphincter of Oddi manometry (SOM), performed at endoscopic retrograde cholangiopancreatography (ERCP), is the gold standard for diagnosing sphincter of Oddi dysfunction (SOD)...
  2. Zhang X, Cui G, Ma K, Wang S, Wei Y, Du P, et al. Sphincter of Oddi dysfunction in hypercholesterolemic rabbits. Eur J Gastroenterol Hepatol. 2008;20:202-8 pubmed publisher
    ..The sphincter of Oddi (SO) plays important roles in the regulation of gallbladder evacuation and maintenance of normal hydraulic ..
  3. Katsinelos P, Dimiropoulos S, Katsiba D, Arvaniti M, Tsolkas P, Galanis I, et al. Pseudomonas aeruginosa liver abscesses after diagnostic endoscopic retrograde cholangiography in two patients with sphincter of Oddi dysfunction type 2. Surg Endosc. 2002;16:1638 pubmed
    Patients with sphincter of Oddi dysfunction have a significantly increased rate of pancreatitis after manometry or sphincterotomy, but septic complications after diagnostic endoscopic retrograde cholangiopancreatography (ERCP) in ..
  4. Pop C, Purc─âreanu A, Purcarea M, Andronescu D. The functional sphincter of Oddi disorder. J Med Life. 2008;1:118-29 pubmed
    The sphincter of Oddi disorder (SOD) has been a controversial subject for many years, about which a lot has been written...
  5. Fogel E, Eversman D, Jamidar P, Sherman S, Lehman G. Sphincter of Oddi dysfunction: pancreaticobiliary sphincterotomy with pancreatic stent placement has a lower rate of pancreatitis than biliary sphincterotomy alone. Endoscopy. 2002;34:280-5 pubmed
    Patients with suspected or documented sphincter of Oddi dysfunction (SOD) who undergo standard biliary sphincterotomy have high rates of post-procedure pancreatitis...
  6. Sharma S. Sphincter of Oddi dysfunction in patients addicted to opium: an unrecognized entity. Gastrointest Endosc. 2002;55:427-30 pubmed
    Opiate-induced sphincter of Oddi dysfunction (SOD) as a clinical entity has not been described.
  7. Thompson D. Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis. Am J Gastroenterol. 2001;96:1266-72 pubmed
    Traditional teaching dictates that morphine induces "spasm" in the sphincter of Oddi (SO) and should not be used in acute pancreatitis and that meperidine is the analgesic of choice because it does not elevate SO pressures...
  8. Kaw M, Brodmerkel G. ERCP, biliary crystal analysis, and sphincter of Oddi manometry in idiopathic recurrent pancreatitis. Gastrointest Endosc. 2002;55:157-62 pubmed
    This study investigated the role of ERCP, analysis of bile for microcrystals, and sphincter of Oddi manometry in idiopathic recurrent pancreatitis.
  9. Vracko J, Wiechel K. Increased gallbladder trypsin in acute cholecystitis indicates functional disorder in the sphincter of oddi and could make EPT a logical procedure. Surg Laparosc Endosc Percutan Tech. 2003;13:308-13 pubmed
    ..Such a study is underway to assess the possible role of obstruction at, or other disorders of, the sphincter of Oddi with consequent pancreatic juice reflux into the gallbladder as a possible initial cause of ACh.

Scientific Experts

More Information

Publications62

  1. Uchida N, Tsutsui K, Ezaki T, Fukuma H, Kamata H, Kobara H, et al. Estimation of the stent placement above the intact sphincter of Oddi against malignant bile duct obstruction. J Gastroenterol. 2005;40:291-6 pubmed
    ..Stent blockage occurs as a result of bacterial adherence to the inner wall of the stent. We evaluated the stent placement above the intact sphincter of Oddi to retain the function of the sphincter of Oddi as a bacteriological barrier.
  2. Brodsky J, Marks J, Malm J, Bower A, Ponsky J. Sphincter of Oddi injection with botulinum toxin is as effective as endobiliary stent in resolving cystic duct leaks in a canine model. Gastrointest Endosc. 2002;56:849-51 pubmed
    ..This study compared time to bile leak resolution for endoscopic stent insertion versus injection of botulinum toxin into the sphincter of Oddi.
  3. Behar J, Corazziari E, Guelrud M, Hogan W, Sherman S, Toouli J. Functional gallbladder and sphincter of oddi disorders. Gastroenterology. 2006;130:1498-509 pubmed
    ..The functional disorders of the sphincter of Oddi (SO) encompass motor abnormalities of either the biliary or the pancreatic SO...
  4. Fazel A, Li S, Burton F. Octreotide relaxes the hypertensive sphincter of Oddi: pathophysiological and therapeutic implications. Am J Gastroenterol. 2002;97:612-6 pubmed
    As our understanding of the pathophysiology of sphincter of Oddi dysfunction (SOD) expands, new avenues arise for pharmacological intervention...
  5. Corazziari E, Cicala M, Scopinaro F, Schillaci O, Habib I, Pallotta N. Scintigraphic assessment of SO dysfunction. Gut. 2003;52:1655-6 pubmed
  6. Arguedas M, Linder J, Wilcox C. Suspected sphincter of Oddi dysfunction type II: empirical biliary sphincterotomy or manometry-guided therapy?. Endoscopy. 2004;36:174-8 pubmed
    b>Sphincter of Oddi manometry is considered to be the gold standard for diagnosing sphincter of Oddi dysfunction (SOD)...
  7. Inkinen J, Sand J, Arvola P, Porsti I, Nordback I. Direct effect of thyroxine on pig sphincter of Oddi contractility. Dig Dis Sci. 2001;46:182-6 pubmed
    b>Sphincter of Oddi (SO) motility has an important role in the regulation of bile flow...
  8. Singh P, Gurudu S, Davidoff S, Sivak M, Indaram A, Kasmin F, et al. Sphincter of Oddi manometry does not predispose to post-ERCP acute pancreatitis. Gastrointest Endosc. 2004;59:499-505 pubmed
    b>Sphincter of Oddi manometry is helpful in selecting patients with sphincter of Oddi dysfunction who will respond to sphincterotomy...
  9. Cicala M, Habib F, Fiocca F, Pallotta N, Corazziari E. Increased sphincter of Oddi basal pressure in patients affected by gall stone disease: a role for biliary stasis and colicky pain?. Gut. 2001;48:414-7 pubmed
    Even if the motor activity of the gall bladder and sphincter of Oddi (SO) are integrated, it is not known if the presence of stones in the gall bladder affects SO function...
  10. Velosy B, Madacsy L, Szepes A, Pavics L, Csernay L, Lonovics J. The effects of somatostatin and octreotide on the human sphincter of Oddi. Eur J Gastroenterol Hepatol. 1999;11:897-901 pubmed
    ..The aim of the present work was to study the effects of somatostatin and octreotide on the human sphincter of Oddi by means of quantitative hepatobiliary scintigraphy (QHBS).
  11. Chen P, Hu B, Tan Q, Liu L, Li D, Jiang C, et al. Role of neurocrine somatostatin on sphincter of Oddi contractility and intestinal ischemia reperfusion-induced acute pancreatitis in macaques. Neurogastroenterol Motil. 2010;22:935-41, e240 pubmed publisher
    Intestinal ischemia-reperfusion (IIR) is implicated in the pathogenesis of severe acute pancreatitis (SAP). This study investigates the impact of neurocrine somatostatin (SST) on the contraction of sphincter of Oddi (SO) during IIR.
  12. Talwar A, Dare C, Pain J. Does topical GTN on the sphincter of Oddi facilitate ERCP? A double-blind randomized control trial. Surg Endosc. 2005;19:902-4 pubmed
    ..Glyceryl trinitrate (GTN) has been shown to reduce tone in the sphincter of Oddi (SO), cannulation of which is a rate-limiting factor...
  13. Turan M, Bagcivan I, Gursoy S, Sarac B, Duman M, Kaya T. In vitro effects of intravenous anesthetics on the sphincter of Oddi strips of sheep. Pancreatology. 2005;5:215-9 pubmed
    ..often used for conscious sedation in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincter of Oddi (SO) manometry...
  14. Sand J, Arvola P, Nordback I. Calcium channel antagonists and inhibition of human sphincter of Oddi contractions. Scand J Gastroenterol. 2005;40:1394-7 pubmed
    Nifedipine has been used in the treatment of sphincter of Oddi dyskinesia, a biliary disease characterized by upper abdominal pains and increased pressure in the sphincter...
  15. Chen J, Schloithe A, Toouli J, Saccone G. Endothelin-1 stimulates sphincter of Oddi motility and decreases trans-sphincteric flow: a possible mechanism contributes to cholestasis in disease states. Neurogastroenterol Motil. 2003;15:393-400 pubmed
    Endothelin-1 (ET-1) is a potent stimulator of gallbladder contractility. Its role in modulation of sphincter of Oddi (SO) motility and trans-sphincteric flow (TSF) has not been evaluated...
  16. Sgouros S, Pereira S. Systematic review: sphincter of Oddi dysfunction--non-invasive diagnostic methods and long-term outcome after endoscopic sphincterotomy. Aliment Pharmacol Ther. 2006;24:237-46 pubmed
    b>Sphincter of Oddi dysfunction is a benign, functional gastrointestinal disorder for which invasive endoscopic therapy with potential complications is often recommended.
  17. Petersen B. An evidence-based review of sphincter of Oddi dysfunction: part I, presentations with "objective" biliary findings (types I and II). Gastrointest Endosc. 2004;59:525-34 pubmed
  18. Sostre S, Kalloo A, Spiegler E, Camargo E, Wagner H. A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: the scintigraphic score. J Nucl Med. 1992;33:1216-22 pubmed
    The ideal noninvasive test of sphincter of Oddi dysfunction (SOD) does not exist and the diagnosis of patients with postcholecystectomy pain often relies on invasive procedures...
  19. Sherman S. What is the role of ERCP in the setting of abdominal pain of pancreatic or biliary origin (suspected sphincter of Oddi dysfunction)?. Gastrointest Endosc. 2002;56:S258-66 pubmed
  20. Cheon Y, Cho Y, Moon J, Im H, Jung Y, Lee J, et al. Effects of vardenafil, a phosphodiesterase type-5 inhibitor, on sphincter of Oddi motility in patients with suspected biliary sphincter of Oddi dysfunction. Gastrointest Endosc. 2009;69:1111-6 pubmed publisher
    The therapeutic approach in patients with sphincter of Oddi (SO) dysfunction (SOD) aims to reduce the resistance to the flow of bile or pancreatic juice...
  21. Butler K, Selden B, Pollack C. Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient. J Emerg Med. 2001;21:129-31 pubmed
    Spasm of the sphincter of Oddi is a well-recognized effect of the narcotic class of drugs. Although it is usually clinically silent, such spasm occasionally causes debilitating pain that may be mistaken for more serious disorders...
  22. Quallich L, Stern M, Rich M, Chey W, Barnett J, Elta G. Bile duct crystals do not contribute to sphincter of Oddi dysfunction. Gastrointest Endosc. 2002;55:163-6 pubmed
    ..postcholecystectomy pain by causing temporary biliary obstruction and may be more common in patients with sphincter of Oddi dysfunction...
  23. Devereaux B, Sherman S, Lehman G. Sphincter of Oddi (pancreatic) hypertension and recurrent pancreatitis. Curr Gastroenterol Rep. 2002;4:153-9 pubmed
    Major papilla pancreatic sphincter dysfunction, a variant of sphincter of Oddi dysfunction, causes pancreatitis and pancreatic-type pain...
  24. Cicala M, Habib F, Vavassori P, Pallotta N, Schillaci O, Costamagna G, et al. Outcome of endoscopic sphincterotomy in post cholecystectomy patients with sphincter of Oddi dysfunction as predicted by manometry and quantitative choledochoscintigraphy. Gut. 2002;50:665-8 pubmed
    b>Sphincter of Oddi dysfunction is diagnosed at manometry and, after cholecystectomy, non-invasively at quantitative choledochoscintigraphy. Patients may benefit from endoscopic sphincterotomy.
  25. Fazel A, Burton F. A controlled study of the effect of midazolam on abnormal sphincter of Oddi motility. Gastrointest Endosc. 2002;55:637-40 pubmed
    The effect of a medication on sphincter of Oddi motility should be characterized if it is to be used during sphincter of Oddi manometry. Controversy exists as to whether midazolam influences sphincter of Oddi motility...
  26. Tzovaras G, Rowlands B. Transduodenal sphincteroplasty and transampullary septectomy for sphincter of Oddi dysfunction. Ann R Coll Surg Engl. 2002;84:14-9 pubmed
    The diagnosis and management of sphincter of Oddi dysfunction are controversial issues. Both surgical and endoscopic series report modest success in the treatment of this condition...
  27. Varadarajulu S, Hawes R, Cotton P. Determination of sphincter of Oddi dysfunction in patients with prior normal manometry. Gastrointest Endosc. 2003;58:341-4 pubmed
    Assessment of sphincter of Oddi motility by manometry is limited to a finite time period, and the presence of a motor disorder that is intermittent may not be documented...
  28. Sari R, Nemeth J, Porszasz R, Horvath P, Blasig I, Ferdinandy P, et al. Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi. Eur J Pharmacol. 2001;432:91-7 pubmed
    ..inhibition of cholesterol biosynthesis by lovastatin influenced the nitrergic relaxation response of the sphincter of Oddi. Rabbit sphincters of Oddi rings were tested for changes in isometric tension in response to field ..
  29. Wu S, Kong J, Wang W, Zhang Q, Jin J. Effect of morphine and M-cholinoceptor blocking drugs on human sphincter of Oddi during choledochofiberscopy manometry. Hepatobiliary Pancreat Dis Int. 2003;2:121-5 pubmed
    To evaluate the effects of morphine on the human sphincter of Oddi pressure and the antagonism of anticholinergic agents against morphine.
  30. Draganov P, Kowalczyk L, Forsmark C. Prospective trial comparing solid-state catheter and water-perfusion triple-lumen catheter for sphincter of Oddi manometry done at the time of ERCP. Gastrointest Endosc. 2009;70:92-5 pubmed publisher
    b>Sphincter of Oddi manometry is the reference standard for the diagnosis of sphincter of Oddi dysfunction. Numerous studies have established ranges of normal values as well as typical readings in pathologic conditions...
  31. Yasuda I, Tomita E, Enya M, Kato T, Moriwaki H. Can endoscopic papillary balloon dilation really preserve sphincter of Oddi function?. Gut. 2001;49:686-91 pubmed
    Endoscopic papillary balloon dilation (EPBD) is assumed to preserve sphincter of Oddi function because it causes little trauma to the papilla. However, few studies have addressed this issue specifically...
  32. Szilvassy Z, Sari R, Nemeth J, Nagy I, Csati S, Lonovics J. Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. Eur J Pharmacol. 1998;353:75-8 pubmed
    Field stimulation relaxed the rabbit sphincter of Oddi muscle rings after incubation with atropine (1 microM) and guanethidine (4 microM) with a threefold increase in tissue cyclic cGMP content, a response previously shown to be ..
  33. Pereira S, Gillams A, Sgouros S, Webster G, Hatfield A. Prospective comparison of secretin-stimulated magnetic resonance cholangiopancreatography with manometry in the diagnosis of sphincter of Oddi dysfunction types II and III. Gut. 2007;56:809-13 pubmed
    In sphincter of Oddi dysfunction (SOD), sphincter of Oddi manometry (SOM) predicts the response to sphincterotomy, but is invasive and associated with complications.
  34. Sonoda Y, Kawamoto M, Woods C, Schloithe A, Carati C, Toouli J, et al. Sphincter of Oddi function in the Australian brush-tailed possum is inhibited by intragastric ethanol. Neurogastroenterol Motil. 2007;19:401-10 pubmed
    The role of sphincter of Oddi (SO) function in alcoholic acute pancreatitis (AP) is unclear. We aimed to compare the effect of i.v. and intragastric (IG) ethanol on SO function (i.e...
  35. Wehrmann T, Stergiou N, Schmitt T, Dietrich C, Seifert H. Reduced risk for pancreatitis after endoscopic microtransducer manometry of the sphincter of Oddi: a randomized comparison with the perfusion manometry technique. Endoscopy. 2003;35:472-7 pubmed
    Endoscopic microtransducer manometry of the sphincter of Oddi has been shown to be a reliable alternative to perfusion manometry for evaluating sphincter of Oddi motor function...
  36. Mariani A, Curioni S, Zanello A, Passaretti S, Masci E, Rossi M, et al. Secretin MRCP and endoscopic pancreatic manometry in the evaluation of sphincter of Oddi function: a comparative pilot study in patients with idiopathic recurrent pancreatitis. Gastrointest Endosc. 2003;58:847-52 pubmed
    b>Sphincter of Oddi dysfunction plays an important etiologic role in idiopathic acute recurrent pancreatitis...
  37. Linder J, Klapow J, Linder S, Wilcox C. Incomplete response to endoscopic sphincterotomy in patients with sphincter of Oddi dysfunction: evidence for a chronic pain disorder. Am J Gastroenterol. 2003;98:1738-43 pubmed
    The efficacy of endoscopic treatment of sphincter of Oddi dysfunction (SOD) with endoscopic sphincterotomy (ES) remains controversial...
  38. Sugawa C, Park D, Lucas C, Higuchi D, Ukawa K. Endoscopic sphincterotomy for stenosis of the sphincter of Oddi. Surg Endosc. 2001;15:1004-7 pubmed
    b>Sphincter of Oddi dysfunction (SOD) is one of the causes of postcholecytectomy syndrome and biliary pain. Endoscopic sphincterotomy (EST) is recommended in some cases for patients refractory to conservative treatment...
  39. Coyle W, Pineau B, Tarnasky P, Knapple W, Aabakken L, Hoffman B, et al. Evaluation of unexplained acute and acute recurrent pancreatitis using endoscopic retrograde cholangiopancreatography, sphincter of Oddi manometry and endoscopic ultrasound. Endoscopy. 2002;34:617-23 pubmed
    ..The aim of this study was to determine the diagnostic utility of endoscopic retrograde cholangiopancreatography (ERCP) with sphincter of Oddi manometry (SOM), bile analysis, and endoscopic ultrasound (EUS) in evaluating such patients.
  40. Piccinni G, Angrisano A, Testini M, Bonomo G. Diagnosing and treating Sphincter of Oddi dysfunction: a critical literature review and reevaluation. J Clin Gastroenterol. 2004;38:350-9 pubmed
    b>Sphincter of Oddi dysfunction is a pathologic syndrome, without considering etiology, physiopathology, or anatomic aspects of the condition...
  41. Tanaka M. Function and dysfunction of the sphincter of Oddi. Dig Surg. 2010;27:94-9 pubmed publisher
    In this review, the function of the sphincter of Oddi (SO) is detailed in terms of normal motility, neural and hormonal control of SO function, coordination between gallbladder and SO motility, and correlation of motility of the SO and ..
  42. Sherman S, Ruffolo T, Hawes R, Lehman G. Complications of endoscopic sphincterotomy. A prospective series with emphasis on the increased risk associated with sphincter of Oddi dysfunction and nondilated bile ducts. Gastroenterology. 1991;101:1068-75 pubmed
    Mostly retrospective series with limited use of sphincter of Oddi manometry have indicated that early complications are more common when endoscopic sphincterotomy is performed for sphincter of Oddi dysfunction than for common duct stones...
  43. Laukkarinen J, Sand J, Aittomaki S, Porsti I, Koobi P, Kalliovalkama J, et al. Mechanism of the prorelaxing effect of thyroxine on the sphincter of Oddi. Scand J Gastroenterol. 2002;37:667-73 pubmed
    Disturbances in the function of sphincter of Oddi (SO) may prevent normal bile flow and thus enhance the probability of common bile duct stone (CBDS) formation...
  44. Park S, Watkins J, Fogel E, Sherman S, Lazzell L, Bucksot L, et al. Long-term outcome of endoscopic dual pancreatobiliary sphincterotomy in patients with manometry-documented sphincter of Oddi dysfunction and normal pancreatogram. Gastrointest Endosc. 2003;57:483-91 pubmed
    For patients with sphincter of Oddi dysfunction and abnormal pancreatic basal sphincter pressure, additional pancreatic sphincterotomy has been recommended...
  45. Craig A, Chen L, Saccone G, Chen J, Padbury R, Toouli J. Sphincter of Oddi dysfunction associated with choledochal cyst. J Gastroenterol Hepatol. 2001;16:230-4 pubmed
    ..b>Sphincter of Oddi (SO) manometry was performed in three patients with choledochal cysts...
  46. Wehrmann T, Schmitt T, Schonfeld A, Caspary W, Seifert H. Endoscopic sphincter of Oddi manometry with a portable electronic microtransducer system: comparison with the perfusion manometry method and routine clinical application. Endoscopy. 2000;32:444-51 pubmed
    Endoscopic perfusion manometry (PM) of the sphincter of Oddi (SO) requires expensive equipment which is relatively large and uncomfortable to handle in the endoscopic retrograde cholangiopancreatography (ERCP) setting...
  47. Varadarajulu S, Hawes R. Key issues in sphincter of Oddi dysfunction. Gastrointest Endosc Clin N Am. 2003;13:671-94 pubmed
    ..All procedures on the sphincter should be undertaken with caution after meticulous investigation, and patient selection should be based on strict objective criteria...
  48. Mandryka Y, Klimczak J, Duszewski M, Kondras M, Modzelewski B. [Bile duct infections as a late complication after endoscopic sphincterotomy]. Pol Merkur Lekarski. 2006;21:525-7 pubmed
    ..Nevertheless patients after invasive procedures concerning bile ducts with destruction of Oddi's sphincter often have increased succeptibility to chronic infections of bile ducts...
  49. Al Jiffry B, Chen J, Toouli J, Saccone G. Endothelins induce gallbladder contraction independent of elevated blood pressure in vivo in the Australian possum. J Gastrointest Surg. 2002;6:699-705 pubmed
    ..05). Endothelins increase gallbladder motility in vivo, acting directly on the smooth muscle and independent of changes in blood pressure...
  50. Zhang H, Tsang T, Pollack J, Jack C. Evaluation of role of bile flow patterns in process of in vitro stent occlusion. Dig Dis Sci. 2002;47:2691-5 pubmed
    Stent placement above the sphincter of Oddi might have advantages over stent placement across the sphincter of Oddi in prolonging stent patency in the treatment for malignant obstructive jaundice...
  51. Cannici F, Sommariva S, Castrati G. [The surgical treatment of biliary lithiasis in the patient of an advanced age]. Minerva Chir. 1992;47:1189-91 pubmed
    ..The indications for surgery are examined taking into account the possibilities offered by the introduction of new technologies, and in particular preoperative EPST...
  52. Dill J, Dill B. Sphincter of Oddi manometry and bile crystals. Gastrointest Endosc. 2004;60:862-3; author reply 863 pubmed
  53. Woods C, Saccone G. Neurohormonal regulation of the sphincter of Oddi. Curr Gastroenterol Rep. 2007;9:165-70 pubmed
    The control of sphincter of Oddi (SO) motor activity is complex and involves interactions between the SO smooth muscle with nerves, bioactive agents, and presumably interstitial cells of Cajal...