extrahepatic bile ducts

Summary

Summary: Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).

Top Publications

  1. Kobayashi T, Harada K, Miwa K, Nakanuma Y. Helicobacter genus DNA fragments are commonly detectable in bile from patients with extrahepatic biliary diseases and associated with their pathogenesis. Dig Dis Sci. 2005;50:862-7 pubmed
    ..bilis are commonly detectable in the bile of patients with extrahepatic biliary diseases, whether benign or malignant, implying that the Helicobacter genus may be directly or indirectly involved in the pathogenesis of these diseases...
  2. Balbinot R, Gobbato A, Balbinot S, Mendonça L, Tefilli N, Lain V, et al. Double bile duct with ectopic drainage into stomach. Gastrointest Endosc. 2004;60:661-2 pubmed
  3. Honjo Y, Kobayashi Y, Nakamura T, Takehira Y, Kitagawa M, Ikematsu Y, et al. Extrahepatic biliary schwannoma. Dig Dis Sci. 2003;48:2221-6 pubmed
    ..The final diagnosis was benign schwannoma of the common bile duct. The tumor differed from usual soft tissue schwannoma and closely resembled gastrointestinal schwannoma...
  4. Henson D, Schwartz A, Nsouli H, Albores Saavedra J. Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla of vater share a field for carcinogenesis: a population-based study. Arch Pathol Lab Med. 2009;133:67-71 pubmed publisher
    Carcinomas co-occur in the pancreas, extrahepatic bile ducts, and ampulla of Vater. We investigated whether cancers originating in these sites represent a field effect similar to that observed in the lung and upper aerodigestive tract.
  5. Ahmadi O, Nicholson M, Gould M, Mitchell A, Stringer M. Interstitial cells of Cajal are present in human extrahepatic bile ducts. J Gastroenterol Hepatol. 2010;25:277-85 pubmed publisher
    ..ICC were recently discovered in the wall of the human gallbladder. This study sought to determine whether ICC are present in human bile ducts...
  6. Shimizu Y, Ohtsuka M, Ito H, Kimura F, Shimizu H, Togawa A, et al. Should the extrahepatic bile duct be resected for locally advanced gallbladder cancer?. Surgery. 2004;136:1012-7; discussion 1018 pubmed
    ..The incidence and mode of spread of carcinoma of the gallbladder into the hepatoduodenal ligament have not been well described pathologically for gallbladder carcinoma extending into the subserosa and beyond...
  7. El Rassi Z, Mohsine R, Berger F, Thierry P, Partensky C. Endocrine tumors of the extrahepatic bile ducts. Pathological and clinical aspects, surgical management and outcome. Hepatogastroenterology. 2004;51:1295-300 pubmed
    Endocrine tumors of the extrahepatic bile ducts are an extremely rare clinical entity with only very few cases being reported to date...
  8. Park M, Kim T, Kim K, Park S, Lee J, Kim J, et al. Differentiation of extrahepatic bile duct cholangiocarcinoma from benign stricture: findings at MRCP versus ERCP. Radiology. 2004;233:234-40 pubmed
  9. Shivakumar P, Campbell K, Sabla G, Miethke A, Tiao G, McNeal M, et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004;114:322-9 pubmed
    ..resulting in progressive jaundice, growth failure, and greater than 90% mortality due to obstruction of extrahepatic bile ducts. In this model, the genetic loss of IFN-gamma did not alter the onset of jaundice, but it remarkably ..

More Information

Publications62

  1. Malka D, Boige V, Dromain C, Debaere T, Pocard M, Ducreux M. Biliary tract neoplasms: update 2003. Curr Opin Oncol. 2004;16:364-71 pubmed
    ..This reality has fostered therapeutic nihilism, and most physicians and surgeons, in their pessimism, have to run ambitious trials evaluating new diagnostic tools and therapeutic techniques in this disease...
  2. Portella A, Trindade M, Dias L, Goldenberg S, Trindade E. Monopolar electrosurgery on the extrahepatic bile ducts during laparoscopic cholecystectomy: an experimental controlled trial. Surg Laparosc Endosc Percutan Tech. 2009;19:213-6 pubmed publisher
    The purpose of this study is to investigate the occurrence of thermal injury in the extrahepatic bile ducts when monopolar electrosurgery is used to perform dieresis of the cystic duct and cystic vessels in laparoscopic cholecystectomy.
  3. Matsui A, Tanaka E, Choi H, Winer J, Kianzad V, Gioux S, et al. Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents. Surgery. 2010;148:87-95 pubmed publisher
    ..the invisible near-infrared (NIR) fluorescence properties of methylene blue (MB) and indocyanine green (ICG) could be exploited for real-time, intraoperative imaging of the extrahepatic bile ducts during open and laparoscopic surgeries.
  4. Takamura A, Saito H, Kamada T, Hiramatsu K, Takeuchi S, Hasegawa M, et al. Intraluminal low-dose-rate 192Ir brachytherapy combined with external beam radiotherapy and biliary stenting for unresectable extrahepatic bile duct carcinoma. Int J Radiat Oncol Biol Phys. 2003;57:1357-65 pubmed
    ..To evaluate the results of combined-modality therapy, including external beam radiotherapy, intraluminal (192)Ir, and biliary stenting for extrahepatic bile duct carcinoma...
  5. Sakamoto Y, Kosuge T, Shimada K, Sano T, Hibi T, Yamamoto J, et al. Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer. J Surg Oncol. 2006;94:298-306 pubmed
    ..The aim of this study was to determine the clinical significance of extrahepatic bile duct (EHBD) resection during surgery for advanced gallbladder cancer...
  6. Khunamornpong S, Lerwill M, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai W, et al. Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol. 2008;27:366-79 pubmed publisher
    Information on ovarian metastasis of carcinoma of the extrahepatic bile ducts and gallbladder is limited...
  7. Choi E, Byun J, Park B, Lee M. Duplication of the extrahepatic bile duct with anomalous union of the pancreaticobiliary ductal system revealed by MR cholangiopancreatography. Br J Radiol. 2007;80:e150-4 pubmed
    ..This variant of a duplication of the extrahepatic biliary system has not been described previously in the literature...
  8. Dutton J, Chillingworth N, Eberhard D, Brannon C, Hornsey M, Tosh D, et al. Beta cells occur naturally in extrahepatic bile ducts of mice. J Cell Sci. 2007;120:239-45 pubmed
    ..The mammalian bile-duct-derived beta cells might therefore represent an extant trace of the evolutionary origin of the vertebrate beta cell...
  9. Tanaka E, Choi H, Humblet V, Ohnishi S, Laurence R, Frangioni J. Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light. Surgery. 2008;144:39-48 pubmed publisher
    Currently, only x-ray fluoroscopy is available for visualization of the extrahepatic bile ducts intraoperatively...
  10. Itatsu K, Zen Y, Yamaguchi J, Ohira S, Ishikawa A, Ikeda H, et al. Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts. Hum Pathol. 2008;39:710-9 pubmed publisher
    Cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts (collectively referred to as the large bile ducts) is an intractable disease, and a papillary phenotype and well-differentiated histologic grade have been proposed ..
  11. Shin H, Seong J, Kim W, Lee H, Moon S, Lee I, et al. Combination of external beam irradiation and high-dose-rate intraluminal brachytherapy for inoperable carcinoma of the extrahepatic bile ducts. Int J Radiat Oncol Biol Phys. 2003;57:105-12 pubmed
    To assess the feasibility and therapeutic benefits of a combination of external beam radiotherapy (EBRT) and high-dose-rate intraluminal brachytherapy (ILBT) for treating patients with inoperable carcinoma of the extrahepatic bile ducts.
  12. Hoang M, Murakata L, Katabi N, Henson D, Albores Saavedra J. Invasive papillary carcinomas of the extrahepatic bile ducts: a clinicopathologic and immunohistochemical study of 13 cases. Mod Pathol. 2002;15:1251-8 pubmed
    Carcinomas of the extrahepatic bile ducts are uncommon neoplasms that are morphologically heterogeneous and associated with a poor prognosis...
  13. Jarnagin W. Cholangiocarcinoma of the extrahepatic bile ducts. Semin Surg Oncol. 2000;19:156-76 pubmed
    Malignancies of the biliary tree, particularly the extrahepatic bile ducts, remain difficult clinical problems...
  14. Chen W, Ying D, Liu Z, He Z. Analysis of the arterial supply of the extrahepatic bile ducts and its clinical significance. Clin Anat. 1999;12:245-9 pubmed
    ..The patterns are: a network, a longitudinal anastomotic chain, and an arterial circle. These data emphasize the importance of the arterial supply in biliary surgery and especially the treatment of hemobilia...
  15. Hsing A, Gao Y, Devesa S, Jin F, Fraumeni J. Rising incidence of biliary tract cancers in Shanghai, China. Int J Cancer. 1998;75:368-70 pubmed
    ..The increase in incidence was seen for all 3 subsites, both sexes, and all age groups. Future studies are needed to identify reasons for the large increases in these rates...
  16. Kurosaki I, Watanabe H, Tsukada K, Hatakeyama K. Synchronous primary tumors of the extrahepatic bile duct and gallbladder. J Surg Oncol. 1997;65:258-62 pubmed
    ..Understanding multiplicity and its histologic confirmation is an important step for successful surgical management...
  17. Mokuno Y, Katoh T, Yoshida K, Abe T, Maeda M, Chigira H. Undifferentiated spindle cell carcinoma of the extrahepatic bile ducts: a case report. Hepatogastroenterology. 2000;47:1234-7 pubmed
    ..We report an 81-year-old man with spindle cell carcinoma located in the extrahepatic bile ducts, resulting in obstructive jaundice. The patient died 10 months after operation due to local recurrence...
  18. Levy A, Murakata L, Abbott R, Rohrmann C. From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Armed Forces Institute of Pathology. Radiographics. 2002;22:387-413 pubmed
    ..However, the differential diagnosis should include benign tumors and tumorlike lesions. The preoperative determination of a benign lesion may significantly alter therapy and patient prognosis...
  19. Ferluga D, Luzar B, Gadzijev E. Follicular lymphoma of the gallbladder and extrahepatic bile ducts. Virchows Arch. 2003;442:136-40 pubmed
    ..was classified as an extranodal follicular lymphoma, grade II of the gallbladder, involving also hilar extrahepatic bile ducts. To the best of our knowledge, this is the first report of an extranodal follicular lymphoma in this ..
  20. Kaneoka Y, Yamaguchi A, Isogai M, Harada T, Suzuki M. Hepatoduodenal ligament invasion by gallbladder carcinoma: histologic patterns and surgical recommendation. World J Surg. 2003;27:260-5 pubmed
    ..9%. There were no 5-year survivors with BDI. In conclusion, perineural invasion in BDI is an important obstacle to complete resection. Hepatopancreatoduodenectomy is a feasible strategy only for LNI(+)BDI(-) disease...
  21. Hribernik M, Gadzijev E, Mlakar B, Ravnik D. Variations of intrahepatic and proximal extrahepatic bile ducts. Hepatogastroenterology. 2003;50:342-8 pubmed
    ..importance for biliary specialists and should include information on variations of intrahepatic and extrahepatic bile ducts. The aim of this study was to find biliary variations, especially on a segmental and sectorial level, and ..
  22. Hori H, Ajiki T, Mita Y, Horiuchi H, Hirata K, Matsumoto T, et al. Frequent activation of mitogen-activated protein kinase relative to Akt in extrahepatic biliary tract cancer. J Gastroenterol. 2007;42:567-72 pubmed
    ..The aim of this study was to examine the expression patterns of phosphorylated MAPK (p-MAPK) and phosphorylated Akt (p-Akt) proteins in BTC cell lines and clinical specimens...
  23. Suzuki Y, Fujino Y, Yoshikawa T, Tanioka Y, Sakai T, Takada M, et al. Intraoperative continuous external bile drainage during pancreaticoduodenectomy. Surg Today. 2004;34:920-4 pubmed
    ..Here, we investigate this phenomenon further...
  24. Choi H. [Assessment of the definition of early extrahepatic bile duct cancer through the prognosis analysis of patients who had received curative resection]. Korean J Gastroenterol. 2007;50:136-9 pubmed
  25. Kayahara M, Nagakawa T, Nakagawara H, Kitagawa H, Ohta T. Prognostic factors for gallbladder cancer in Japan. Ann Surg. 2008;248:807-14 pubmed publisher
    ..The objective of this study was to evaluate prognostic predictors for patients with gallbladder cancer (GBC) in a Japanese nationwide data base...
  26. Dixon E, Sutherland F, Vollmer C, Greig P. Bile duct injury after laparoscopic cholecystectomy: resection of the entire extrahepatic biliary tree. J Am Coll Surg. 2003;197:862-3 pubmed
  27. Herrera L, Martino E, Rodriguez Sanjuan J, Castillo J, Casafont F, Gonzalez F, et al. Traumatic neuroma of extrahepatic bile ducts after orthotopic liver transplantation. Transplant Proc. 2009;41:1054-6 pubmed publisher
    ..We propose a classification to help patient selection for surgery. In our opinion, resection of the TN is the operation of choice, together with resection of the involved biliary tract in type I TN...
  28. Popescu I. [The treatment of extrahepatic bile duct cancer]. Chirurgia (Bucur). 2003;98:199-201 pubmed
  29. Mirza Q, Kvist N, Petersen B. Histologic features of the portal plate in extrahepatic biliary atresia and their impact on prognosis--a Danish study. J Pediatr Surg. 2009;44:1344-8 pubmed publisher
    ..The aims of this study are as follows:..
  30. Owens S, Gossett R, McElhaney M, Christopher M, Shelly S. Three cases of canine bile peritonitis with mucinous material in abdominal fluid as the prominent cytologic finding. Vet Clin Pathol. 2003;32:114-20 pubmed
    ..Cytologically, bile in abdominal fluid appears as golden-green granular pigment...
  31. Pitt H, Nakeeb A. Operative approach to gallbladder cancer. Curr Gastroenterol Rep. 2006;8:161-7 pubmed
    ..randomized studies are available, resection of the gallbladder and adjacent liver with or without the extrahepatic bile ducts and with a regional lymph node dissection is the operative approach recommended for selected patients ..
  32. Hong S, Hwang I, Song D, Choi J, Yu E. Clinical and prognostic significances of nuclear and cytoplasmic KIT expressions in extrahepatic bile duct carcinomas. Mod Pathol. 2007;20:562-9 pubmed
    ..In addition, more frequent nuclear expression of KIT in cases with vascular invasion suggests that nuclear KIT expression may contribute to the progression of extrahepatic bile duct carcinoma...
  33. Aikawa M, Miyazawa M, Okada K, Toshimitsu Y, Torii T, Otani Y, et al. Regeneration of extrahepatic bile duct--possibility to clinical application by recognition of the regenerative process. J Smooth Muscle Res. 2007;43:211-8 pubmed
    ..The creation of this artificial bile duct may be able to promote the development of the treatment for biliary diseases...
  34. Baeza Herrera C, Medellín Sierra U, Sanjuán Fabián H, Jiménez González N, García Cabello L. [A pancreatobiliary malformation causing spontaneous perforation of the extrahepatic bile duct]. Gac Med Mex. 2006;142:79-80 pubmed
    ..Perforation was due to malformation of the pancreatico-biliary junction. An uneventful external derivation by tube was performed...
  35. Gusani N, Marsh J, Nalesnik M, Tublin M, Gamblin T. Carcinoid of the extra-hepatic bile duct: a case report with long-term follow-up and review of literature. Am Surg. 2008;74:87-90 pubmed
    ..Carcinoid tumor of the extrahepatic bile ducts is a reportable lesion, with only approximately 50 cases described in the literature since 1959...
  36. Lazaridis K. Sclerosing cholangitis epidemiology and etiology. J Gastrointest Surg. 2008;12:417-9 pubmed
    ..In contrast, the etiology of secondary sclerosing cholangitis is always known, but the epidemiology of this clinical entity is difficult to study...
  37. Choi J, Lee J, Lee J, Kim S, Lee M, Han J, et al. Assessment of hilar and extrahepatic bile duct cancer using multidetector CT: value of adding multiplanar reformations to standard axial images. Eur Radiol. 2007;17:3130-8 pubmed
    ..The addition of MPR images to the standard axial images did not significantly improve the diagnostic performance of MDCT in the evaluation of the bile duct cancer...
  38. Zardi E, Malafarina V, Ambrosino G, Uwechie V, Rollo M, Picardi A, et al. An unusual post-traumatic case of extrahepatic bile duct compression. Mt Sinai J Med. 2006;73:1093-4 pubmed
    ..Unfortunately, the patient refused either surgical or more conservative treatment and was lost to follow-up...
  39. Ramia J, Gutierrez G, Garrote D, Mansilla A, Villar J, Ferron J. Isolated extrahepatic bile duct rupture in blunt abdominal trauma. Am J Emerg Med. 2005;23:231-2 pubmed
  40. Hong S, Choi J, Ryu K, Ro J, Yu E. Promoter hypermethylation of the p16 gene and loss of its protein expression is correlated with tumor progression in extrahepatic bile duct carcinomas. Arch Pathol Lab Med. 2006;130:33-8 pubmed
    ..Promoter hypermethylation, a mechanism of p16 gene inactivation, has been reported to play an important role in tumorigenesis and to be related to patient prognosis in several carcinomas...
  41. Schweizer P, Petersen M, Drews U, Bachmann C, Schweizer M. Pathogenesis of extrahepatic bile duct atresia (EHBA): comprehension from a surgical point of view. Eur J Pediatr Surg. 2005;15:248-57 pubmed
    ..The aim of the study is to establish a complete comprehension of the pathogenesis of Biliary Atresia, and to explain both the variable and redundant pathomorphological, as well as, histological findings...
  42. Stewart L, Hunter J, Wetter A, Chin B, Way L. Operative reports: form and function. Arch Surg. 2010;145:865-71 pubmed publisher
  43. Noronha Y, Raza A. Well-differentiated neuroendocrine (carcinoid) tumors of the extrahepatic biliary ducts. Arch Pathol Lab Med. 2010;134:1075-9 pubmed publisher
    ..It is important to keep this entity in mind, especially when examining cytologic or small biopsy specimens, so that appropriate immunohistochemical stains can be used to arrive at the correct diagnosis...
  44. Fernández Ruiz M, Guerra Vales J, Colina Ruizdelgado F. Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma. World J Gastroenterol. 2009;15:5279-86 pubmed
    ..To study the outcome and prognostic factors in a series of patients with extrahepatic cholangiocarcinoma and determine the impact of comorbidity on survival...
  45. Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, et al. Surgical strategy for mucin-producing bile duct tumor. J Hepatobiliary Pancreat Sci. 2010;17:236-40 pubmed publisher
    Tumors with copious mucin production within the intra- or extrahepatic bile ducts have been reported as mucin-producing bile duct tumors (MPBTs)...
  46. Yoon Y, Kim S, Jang J, Park Y. Curative reoperation for recurrent cancer of the extrahepatic bile duct: report of two cases. Hepatogastroenterology. 2005;52:381-4 pubmed
    ..A primary operation for bile duct cancer should be performed with a wide surgical margin, and secondary curative surgery should be considered whenever possible in cases of recurrence...
  47. Stroszczynski C, Hunerbein M. Malignant biliary obstruction: value of imaging findings. Abdom Imaging. 2005;30:314-23 pubmed
    ..With newer diagnostic imaging technologies emerging, endoscopic retrograde cholangiopancreatography is evolving into a predominantly therapeutic procedure...
  48. Boutros C, Somasundar P, Espat N. Low common bile duct bifurcation incidentally discovered during pancreaticoduodenectomy. J Gastrointest Surg. 2009;13:2092-3 pubmed publisher
    ..Bile duct injury due to failure to recognize anatomical variations can have considerable consequences...
  49. Muscari F, Dousset B, Sauvanet A. [A difficult cholecystectomy]. J Chir (Paris). 2006;143:93-8 pubmed
  50. Sasaki R, Takeda Y, Funato O, Nitta H, Kawamura H, Uesugi N, et al. Significance of ductal margin status in patients undergoing surgical resection for extrahepatic cholangiocarcinoma. World J Surg. 2007;31:1788-96 pubmed
  51. Petera J, Papík Z, Zouhar M, Jansa J, Odrazka K, Dvorak J. The technique of intensity-modulated radiotherapy in the treatment of cholangiocarcinoma. Tumori. 2007;93:257-63 pubmed
    ..The aim of our dosimetric study was an evaluation of intensity-modulated radiotherapy in the treatment of inoperable bile duct carcinoma...
  52. Schwarzmannová K, Poch T, Simsa J, Vidim T, Chudomel P, Volsanský P, et al. [Pseudoaneurysm of the hepatic artery presenting with hemobilia--a complication of laparoscopic cholecystectomy]. Rozhl Chir. 2008;87:360-3 pubmed
    ..Hemobilia, defined as a bleeding into the bile duct, is a rare disease. One of its infrequent causes is a hepatic artery pseudoaneurysm, usually developed after arterial iatrogenic leasion...
  53. Jiexiong F, Minju L, Hongfeng T, Weizhong G, Shaoyong Y. Clinical and pathological characteristics of cystic lesions of extrahepatic bile duct in neonates. Acta Paediatr. 2003;92:1183-9 pubmed
    ..To investigate the differences in clinical and pathological manifestations between biliary atresia with extrahepatic biliary cyst and choledochal cyst in neonates...