biliary tract

Summary

Summary: The BILE DUCTS and the GALLBLADDER.

Top Publications

  1. Nemeth Z, Szasz A, Tátrai P, Nemeth J, Gyorffy H, Somorácz A, et al. Claudin-1, -2, -3, -4, -7, -8, and -10 protein expression in biliary tract cancers. J Histochem Cytochem. 2009;57:113-21 pubmed publisher
    b>Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly...
  2. Boonyanugomol W, Chomvarin C, Song J, Kim K, Kim J, Cho M, et al. Effects of Helicobacter pylori ?-glutamyltranspeptidase on apoptosis and inflammation in human biliary cells. Dig Dis Sci. 2012;57:2615-24 pubmed
    ..Here, we determined the effects of H. pylori ?-glutamyltranspeptidase (GGT) on the induction of apoptosis and IL-8 production in a human cholangiocarcinoma cell line (KKU-100 cells)...
  3. Kline T, Zamir M, Ritman E. Relating function to branching geometry: a micro-CT study of the hepatic artery, portal vein, and biliary tree. Cells Tissues Organs. 2011;194:431-42 pubmed publisher
  4. Omenetti A, Diehl A. Hedgehog signaling in cholangiocytes. Curr Opin Gastroenterol. 2011;27:268-75 pubmed publisher
    ..Because this has potential implications for liver repair, this review will summarize current knowledge about Hh signaling and cholangiocytes...
  5. Livingston E, Gulaka P, Kommera S, Wang B, Liu H. In vivo spectroscopic characterization of porcine biliary tract tissues: first step in the development of new biliary tract imaging devices. Ann Biomed Eng. 2009;37:201-9 pubmed publisher
    ..The purpose of this work is to characterize the NIR optical properties of bile containing structures that are needed for later development of a clinically useful probe...
  6. Boonyanugomol W, Chomvarin C, Baik S, Song J, Hahnvajanawong C, Kim K, et al. Role of cagA-positive Helicobacter pylori on cell proliferation, apoptosis, and inflammation in biliary cells. Dig Dis Sci. 2011;56:1682-92 pubmed publisher
    ..We compared the effects of H. pylori cagA(+) and cagA(-) mutant strains on cell proliferation, apoptosis, and inflammation in a cholangiocarcinoma (CCA) cell line (KKU-100)...
  7. Cui D, Yin J, Xu W, Chai F, Liu B, Zhang X. Effect of different bile duct flush solutions on biliary tract preservation injury of donated livers for transplantation. Transplant Proc. 2010;42:1576-81 pubmed publisher
    The objective of this study was to explore the effect of various bile duct flush (BDF) solutions on biliary tract preservation of donated livers in rats.
  8. Ando H. Embryology of the biliary tract. Dig Surg. 2010;27:87-9 pubmed publisher
    ..In the 16th week, the muscularis propria extends from just outside the fenestra to the upper end of the ampulla. By the 28th week, the musculus proprius is differentiated almost to the distal end of the ampulla...
  9. Nakanuma Y. A novel approach to biliary tract pathology based on similarities to pancreatic counterparts: is the biliary tract an incomplete pancreas?. Pathol Int. 2010;60:419-29 pubmed publisher
    There are peribiliary glands around the biliary tract, and these glands drain into the bile duct lumen. Interestingly, small amounts of pancreatic exocrine acini are intermingled with these glands...

Scientific Experts

More Information

Publications62

  1. Choi J, Choi J, Kim M, Lim J, Park M, Kim J, et al. Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent. J Magn Reson Imaging. 2010;31:571-8 pubmed publisher
    ..To assess the diagnostic performance of gadobenate dimeglumine-enhanced 3D gradient echo (3D-GRE) magnetic resonance imaging (MRI) for the detection of hepatic hypovascular metastases...
  2. d Aldebert E, Biyeyeme Bi Mve M, Mergey M, Wendum D, Firrincieli D, Coilly A, et al. Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium. Gastroenterology. 2009;136:1435-43 pubmed publisher
    Under normal conditions, the biliary tract is a microbial-free environment. The absence of microorganisms has been attributed to various defense mechanisms that include the physicochemical and signaling actions of bile salts...
  3. Zhou R, Hu G, Gong A, Chen X. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. Nucleic Acids Res. 2010;38:3222-32 pubmed publisher
    ..Thus, a subset of miRNA genes is regulated in human biliary epithelial cells through NF-kappaB activation induced by LPS, suggesting a role of the NF-kappaB pathway in the transcriptional regulation of miRNA genes...
  4. Hu G, Zhou R, Liu J, Gong A, Eischeid A, Dittman J, et al. MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge. J Immunol. 2009;183:1617-24 pubmed publisher
    ..parvum infection. Our data suggest that miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response...
  5. Marsh V, Davies E, Williams G, Clarke A. PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. J Pathol. 2013;230:165-73 pubmed publisher
    Carcinomas of the biliary tract are aggressive malignancies in humans. Loss of the tumour suppressor PTEN has previously been associated with cholangiocarcinoma development in a murine model...
  6. Wang D, Cohen D, Carey M. Biliary lipids and cholesterol gallstone disease. J Lipid Res. 2009;50 Suppl:S406-11 pubmed publisher
  7. Zhao H, Zhang G, Zhou J, Lin J, Cui Z, Li X. Biliary tract injury caused by different relative warm ischemia time in liver transplantation in rats. Hepatobiliary Pancreat Dis Int. 2009;8:247-54 pubmed
    ..This study was undertaken to assess biliary tract injury caused by relative warm ischemia (secondary warm ischemia time in the biliary tract) and reperfusion.
  8. Si Tayeb K, Lemaigre F, Duncan S. Organogenesis and development of the liver. Dev Cell. 2010;18:175-89 pubmed publisher
    ..Here, we review the basic molecular mechanisms that control the formation of the liver as an organ...
  9. Gong A, Hu G, Zhou R, Liu J, Feng Y, Soukup G, et al. MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection. Int J Parasitol. 2011;41:397-403 pubmed publisher
    ..These results indicate that miR-221-mediated translational suppression controls ICAM-1 expression in epithelial cells in response to C. parvum infection...
  10. Fisher R, Thistle J, Lembo A, Novick J, O Kane P, Chey W, et al. Tegaserod does not alter fasting or meal-induced biliary tract motility. Am J Gastroenterol. 2004;99:1342-9 pubmed
    ..The effect of tegaserod on nongut digestive organs, such as the gallbladder and biliary tract, has not been previously investigated...
  11. Gupta A, Stuhlfaut J, Fleming K, Lucey B, Soto J. Blunt trauma of the pancreas and biliary tract: a multimodality imaging approach to diagnosis. Radiographics. 2004;24:1381-95 pubmed
    ..Bile duct injuries can be suggested with CT, which may show ascites and associated liver injuries, and can be confirmed with hepatobiliary scintigraphy...
  12. Murakawa K, Tada M, Takada M, Tamoto E, Shindoh G, Teramoto K, et al. Prediction of lymph node metastasis and perineural invasion of biliary tract cancer by selected features from cDNA array data. J Surg Res. 2004;122:184-94 pubmed
    To better understand the nature of the malignancy of biliary tract carcinoma and evaluate the feasibility of its prediction by gene expression profiles.
  13. Chen J, Yeh B, Wang Z, Roberts J, Breiman R, Qayyum A, et al. Concordance of second-order portal venous and biliary tract anatomies on MDCT angiography and MDCT cholangiography. AJR Am J Roentgenol. 2005;184:70-4 pubmed
    We sought to investigate the concordance between second-order portal venous and biliary tract anatomies using MDCT angiography and MDCT cholangiography.
  14. Foley W, Kerimoglu U. Abdominal MDCT: liver, pancreas, and biliary tract. Semin Ultrasound CT MR. 2004;25:122-44 pubmed
    ..In this chapter, a rational approach to hepatic and pancreatic MDCT acquisition is outlined with emphasis on circulatory phases and contrast material pharmacokinetics as well as biological characteristics of focal parenchymal lesions...
  15. Liu Y, Bair M, Chang W, Lin S, Chan Y. Acute pancreatitis caused by tapeworm in the biliary tract. Am J Trop Med Hyg. 2005;73:377-80 pubmed
    ..Although parasites are not an uncommon cause of pancreatitis, especially in disease-endemic areas, it is rare for Taenia to cause acute pancreatitis...
  16. Saxena R, Theise N, Crawford J. Microanatomy of the human liver-exploring the hidden interfaces. Hepatology. 1999;30:1339-46 pubmed
  17. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, et al. Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg. 2008;15:41-54 pubmed publisher
    The only curative treatment in biliary tract cancer is surgical treatment. Therefore, the suitability of curative resection should be investigated in the first place...
  18. Huang L, Gu W, Si X, Wei M, Feng J. Expression of NF-kappaB in rotavirus-induced damage to the liver and biliary tract in neonatal mice. Hepatobiliary Pancreat Dis Int. 2007;6:188-93 pubmed
    ..In this study, we aimed to investigate the histopathological patterns of different kinds of rotavirus in the liver and biliary tract of neonatal mice and the expression of NF-kappaB in the liver and biliary tract of infected mice.
  19. Schwab D, Grauer M, Hahn E, Mühldorfer S. Biliary secretion of moxifloxacin in obstructive cholangitis and the non-obstructed biliary tract. Aliment Pharmacol Ther. 2005;22:417-22 pubmed
    ..Biliary secretion of antibiotic agents into the bile is considerably compromised by biliary obstruction, a precondition of bacterial cholangitis. Moxifloxacin may be advantageous according to secretion and antimicrobial spectrum...
  20. Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, et al. Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile . Toxicology. 2001;167:83-98 pubmed
    ..Such an interaction might lead potentially also in man to a troglitazone-induced intrahepatic cholestasis, potentially contributing to the formation of troglitazone-induced liver injuries...
  21. Curbishley S, Eksteen B, Gladue R, Lalor P, Adams D. CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am J Pathol. 2005;167:887-99 pubmed
  22. Shitara Y, Sato H, Sugiyama Y. Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. Annu Rev Pharmacol Toxicol. 2005;45:689-723 pubmed
    ..To avoid adverse consequences of such transporter-mediated drug-drug interactions, we need to be more aware of the role played by drug transporters as well as those caused by drug metabolizing enzymes...
  23. Maurer K, Ihrig M, Rogers A, Ng V, Bouchard G, Leonard M, et al. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology. 2005;128:1023-33 pubmed
    ..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model...
  24. Chathadi K, Elta G. Motility and dysmotility of the biliary tract. Semin Gastrointest Dis. 2003;14:199-207 pubmed
    ..However, patients with suspected SOD have the highest complication rate from endoscopic retrograde cholangiogram and sphincterotomy, and, therefore, careful patient selection is mandatory...
  25. Shimotake T, Aoi S, Tomiyama H, Iwai N. DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union. J Pediatr Surg. 2003;38:694-7 pubmed
    ..studies have found that anomalous pancreaticobiliary ductal union (APBDU) is a substantial risk factor for biliary tract cancer at a younger age...
  26. Vladov N. Intraoperative choledochoscopy for the management of liver hydatid cysts opened to the biliary tract. J Gastroenterol Hepatol. 2004;19:836-7 pubmed
  27. Lemaigre F. Development of the biliary tract. Mech Dev. 2003;120:81-7 pubmed
  28. Clotman F, Lannoy V, Reber M, Cereghini S, Cassiman D, Jacquemin P, et al. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development. 2002;129:1819-28 pubmed
    ..The transcription factors that control the development of the biliary tract are unknown...
  29. Murakami T, Sato H, Nakatani S, Taguchi T, Ohtsuka A. Biliary tract of the rat as observed by scanning electron microscopy of cast samples. Arch Histol Cytol. 2001;64:439-47 pubmed
    The three-dimensional distribution of the biliary tract in the rat was studied by scanning electron microscopy of biliary casts...
  30. Swidsinski A, Lee S. The role of bacteria in gallstone pathogenesis. Front Biosci. 2001;6:E93-103 pubmed
  31. Limaye P, Alarcón G, Walls A, Nalesnik M, Michalopoulos G, Demetris A, et al. Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Lab Invest. 2008;88:865-72 pubmed publisher
  32. Ergen F, Akata D, Sarikaya B, Kerimoglu U, Hayran M, Akhan O, et al. Visualization of the biliary tract using gadobenate dimeglumine: preliminary findings. J Comput Assist Tomogr. 2008;32:54-60 pubmed publisher
    ..To compare contrast-enhanced magnetic resonance (MR) cholangiography (CE-MRC) performed with gadobenate dimeglumine with T2-weighted MRC (T2-MRC) for visualization of the bile ducts in nondilated biliary systems...
  33. Hsing A, Gao Y, Han T, Rashid A, Sakoda L, Wang B, et al. Gallstones and the risk of biliary tract cancer: a population-based study in China. Br J Cancer. 2007;97:1577-82 pubmed
    We conducted a population-based study of 627 patients with biliary tract cancers (368 of gallbladder, 191 bile duct, and 68 ampulla of Vater), 1037 with biliary stones, and 959 healthy controls randomly selected from the Shanghai ..
  34. Cabada Giadas T, Sarria Octavio de Toledo L, Martínez Berganza Asensio M, Cozcolluela Cabrejas R, Alberdi Ibáñez I, Alvarez López A, et al. Helical CT cholangiography in the evaluation of the biliary tract: application to the diagnosis of choledocholithiasis. Abdom Imaging. 2002;27:61-70 pubmed
    We evaluated the role of helical computed tomographic (HCT) cholangiography in the study of the biliary tract, especially in the detection of choledocholithiasis, and compared it with direct cholangiography.
  35. Machi J. Laparoscopic ultrasonography: an additional method for potentially preventing biliary tract injury. Surg Endosc. 2008;22:802-3 pubmed
  36. Hedstrom J, Haglund C, Leinonen J, Nordling S, Stenman U. Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas. Scand J Clin Lab Invest. 2001;61:111-8 pubmed
    ..of trypsinogen-1, -2 and tumour-associated trypsin-inhibitor (TATI) were determined in 23 patients with benign biliary tract disease, two with biliary tract cancer, and in 15 with pancreatic cancer...
  37. Itoi T, Takei K, Shinohara Y, Takeda K, Nakamura K, Horibe T, et al. K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers. Pathol Int. 1999;49:30-7 pubmed
    ..To evaluate whether it is useful for diagnosis to detect K-ras and p53 mutations in biopsy specimens and bile of biliary tract lesions, 12 cholangiocarcinomas (CC), eight cases of cholangitis, seven gallbladder carcinomas (GBC), seven ..
  38. Roskams T, Theise N, Balabaud C, Bhagat G, Bhathal P, Bioulac Sage P, et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology. 2004;39:1739-45 pubmed
  39. Tominaga K, Kuriyama S, Yoshiji H, Deguchi A, Kita Y, Funakoshi F, et al. Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies. Gut. 2004;53:1167-73 pubmed
    ..Systemic adenoviral readministration appears to be limited by immunogenicity...
  40. Poddar U, Bhattacharya A, Thapa B, Mittal B, Singh K. Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med. 2004;45:1488-92 pubmed
    ..This study aimed at identifying the role of ursodeoxycholic acid (UDCA), a choleretic agent, in conjunction with hepatobiliary scintigraphy in differentiating extrahepatic biliary atresia from neonatal hepatitis...
  41. Curry M, Hegarty J. The gallbladder and biliary tract in cystic fibrosis. Curr Gastroenterol Rep. 2005;7:147-53 pubmed
    ..Liver transplantation can be performed successfully in patients with end-stage liver disease. Future treatments involve targeted gene therapy and activation of mutant forms of the cystic fibrosis transmembrane conductance regulator...
  42. Marcos L, Terashima A, Gotuzzo E. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis. 2008;21:523-30 pubmed publisher
    ..The present review focuses on current knowledge of clinical, diagnostic and treatment aspects caused by hepatobiliary flukes that can be applied to current protocols in endemic areas...
  43. Cariani S, Palandri P, Della Valle E, Della Valle A, Di Cosmo L, Vassallo C, et al. Italian multicenter experience of Roux-en-Y gastric bypass on vertical banded gastroplasty: four-year results of effective and safe innovative procedure enabling traditional endoscopic and radiographic study of bypassed stomach and biliary tract. Surg Obes Relat Dis. 2008;4:16-25 pubmed
    ..A previously published study demonstrated that complete occlusion of the gastrogastric outlet was not necessary to lose weight. We have developed an open RYGB-on-vertical banded gastroplasty procedure...
  44. Robertson A, Davidson B. Mirizzi syndrome complicating an anomalous biliary tract: a novel cause of a hugely elevated CA19-9. Eur J Gastroenterol Hepatol. 2007;19:167-9 pubmed
    ..surgery, biliary obstruction owing to a gallstone (Type II Mirizzi) was found to be complicating a congenital biliary tract anomaly...
  45. Heinzmann A, Muller T, Leitlein J, Braun B, Kubicka S, Blank W. Endocavitary contrast enhanced ultrasound (CEUS)--work in progress. Ultraschall Med. 2012;33:76-84 pubmed publisher
    ..In addition, to investigate the usefulness of CEUS in applying the agents in the biliary tract or when given orally.
  46. Yashima Y, Tsujino T, Masuzaki R, Nakai Y, Hirano K, Tateishi R, et al. Increased liver elasticity in patients with biliary obstruction. J Gastroenterol. 2011;46:86-91 pubmed publisher
    ..Because little is known about liver elasticity in patients with obstructive jaundice, we evaluated this feature in these patients...
  47. Parasrampuria R, Mehvar R. Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of Rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers. J Pharm Sci. 2010;99:455-66 pubmed publisher
    ..It is concluded that the use of RH-123 in an IPRL model may serve as a dual marker for the determination of the altered functions of P-gp and/or Mrp2...
  48. Yeh B, Coakley F, Webb E, Qayyum A, Westphalen A, Way L. Evaluation of the biliary intestinal limb of a Roux-en-Y choledochojejunostomy using computed tomographic cholangiography. J Comput Assist Tomogr. 2008;32:886-9 pubmed publisher
    ..We conclude that CT cholangiography may help clarify the status of a Roux-en-Y choledochojejunostomy...
  49. Pîglesan C, Dragoteanu M, Grigorescu I, Cosma C. The non-conventional use of 99mTc-Tetrofosmine for dynamic hepatobiliary scintigraphy. Nucl Med Rev Cent East Eur. 2011;14:79-84 pubmed
    ..The possibility to use 99mTc-TF for DHBS may be important in situations when the standardized RF for this procedure (IDA derivatives) is not available...
  50. Ruiz A, Lemoinne S, Carrat F, Corpechot C, Chazouilleres O, Arrive L. Radiologic course of primary sclerosing cholangitis: assessment by three-dimensional magnetic resonance cholangiography and predictive features of progression. Hepatology. 2014;59:242-50 pubmed publisher
    ..These scores were associated with radiologic progression, with an area under the curve of 80 and 83%?±?4%...
  51. Tanimizu N, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T. Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci. 2013;126:5239-46 pubmed publisher
    ..Our results suggest that a molecular machinery augmenting epithelial integrity limits lineage plasticity of epithelial cells...
  52. Sánchez Fernández P, Martínez Ordaz J, Sánchez Reyes K, Ferat Osorio E. [Usefulness of hepatobiliary scintigraphy in the follow-up of patients with biliary reconstruction]. Rev Med Inst Mex Seguro Soc. 2015;53:538-45 pubmed
    The relevance of biliary tract injury patients is not only related to diagnosis and treatment but also to follow-up for the possibility of late complications and medical and legal aspects...
  53. Hawramy T, Saeed K, Qaradaghy S, Karboli T, Nore B, Bayati N. Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate. BMC Res Notes. 2012;5:691 pubmed publisher
    ..We believe that shedding light on this disease in our locality will increase our physician awareness and experience in early detection, treatment in order to avoid unnecessary surgeries...