digestive system

Summary

Summary: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).

Top Publications

  1. Schwaha T, Handschuh S, Redl E, Walzl M. Organogenesis in the budding process of the freshwater bryozoan Cristatella mucedo Cuvier, 1798 (Bryozoa, Phylactolaemata). J Morphol. 2011;272:320-41 pubmed publisher
    ..Nonetheless, our results show that comparative organogenesis can contribute to phylactolaemate systematics and, when more data are available, possibly to that of other bryozoan classes and bilaterian phyla...
  2. Herszenyi L, Mihaly E, Tulassay Z. [Somatostatin and the digestive system. Clinical experiences]. Orv Hetil. 2013;154:1535-40 pubmed publisher
  3. Kim J, Won Y, Nikoh N, Nakayama H, Han S, Kikuchi Y, et al. Polyester synthesis genes associated with stress resistance are involved in an insect-bacterium symbiosis. Proc Natl Acad Sci U S A. 2013;110:E2381-9 pubmed publisher
    ..In vitro culturing analyses confirmed vulnerability of the PHA gene mutants to environmental stresses, suggesting that PHA may play a role in resisting stress under symbiotic conditions. ..
  4. Tziouveli V, Bastos Gomes G, Bastos Gomez G, Bellwood O. Functional morphology of mouthparts and digestive system during larval development of the cleaner shrimp Lysmata amboinensis (de Man, 1888). J Morphol. 2011;272:1080-91 pubmed publisher
    ..The results suggest that early stage L. amboinensis larvae may benefit from soft, perhaps gelatinous prey, whereas later stages are better equipped to handle larger, muscular or more fibrous foods...
  5. Bandyopadhyay P, Ghosh A, Ghosh C. Recent developments on polyphenol–protein interactions: effects on tea and coffee taste, antioxidant properties and the digestive system. Food Funct. 2012;3:592-605 pubmed publisher
    ..trends and patterns (2005 onwards) in polyphenol-protein interaction studies focusing on the characterization of the complex, the effect of this complex formation on tea and coffee taste, antioxidant properties and the digestive system.
  6. Kamps M, Bisschops L, Van Der Hoeven J, Hoedemaekers C. Hypothermia does not increase the risk of infection: a case control study. Crit Care. 2011;15:R48 pubmed publisher
    ..The aim of this study was to investigate the incidence of infections in patients treated with hypothermia and normothermia while receiving SDD...
  7. Moran N, Hansen A, Powell J, Sabree Z. Distinctive gut microbiota of honey bees assessed using deep sampling from individual worker bees. PLoS ONE. 2012;7:e36393 pubmed publisher
    ..Strains showed some differentiation between localities, especially for the Snodgrassella phylotype...
  8. Kikuchi Y, Hayatsu M, Hosokawa T, Nagayama A, Tago K, Fukatsu T. Symbiont-mediated insecticide resistance. Proc Natl Acad Sci U S A. 2012;109:8618-22 pubmed publisher
  9. Eriksson M, Terfelt F. Exceptionally preserved Cambrian trilobite digestive system revealed in 3D by synchrotron-radiation X-ray tomographic microscopy. PLoS ONE. 2012;7:e35625 pubmed publisher
    ..analogous to the labrum of euarthropods and that it was a sophisticated element closely integrated with the digestive system. This study also briefly addresses the preservational bias of the 'Orsten' fauna, particularly the near-..

More Information

Publications62

  1. Cirimotich C, Dong Y, Clayton A, Sandiford S, Souza Neto J, Mulenga M, et al. Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science. 2011;332:855-8 pubmed publisher
    ..We show that this anti-Plasmodium effect is largely caused by bacterial generation of reactive oxygen species...
  2. Loebel D, Studdert J, Power M, Radziewic T, Jones V, Coultas L, et al. Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development. 2011;138:4511-22 pubmed publisher
  3. Lerosey Aubril R, Hegna T, Kier C, Bonino E, Habersetzer J, Carré M. Controls on gut phosphatisation: the trilobites from the Weeks Formation Lagerstätte (Cambrian; Utah). PLoS ONE. 2012;7:e32934 pubmed publisher
    ..However, in some specimens from the Weeks Formation, the phosphatisation extends to the entire digestive system, suggesting that trilobites might have had some biological particularities not observed in modern arthropods...
  4. Niu X, Gao C, Jan Lo L, Luo Y, Meng C, Hong J, et al. Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish. Dev Biol. 2012;367:197-207 pubmed publisher
    ..Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system.
  5. Betcher M, Fung J, Han A, O CONNOR R, Seronay R, Concepcion G, et al. Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS ONE. 2012;7:e45309 pubmed publisher
    ..gills have been studied extensively in several species, the abundance and distribution of microbes in the digestive system have not been adequately addressed...
  6. Sheir S, Handy R, Henry T. Effect of pollution history on immunological responses and organ histology in the marine mussel Mytilus edulis exposed to cadmium. Arch Environ Contam Toxicol. 2013;64:701-16 pubmed publisher
    ..01). We conclude that Cd exposure affected some immune responses in M. edulis, but pre-exposure history influenced toxicological outcomes of Cd exposure in the laboratory...
  7. Li Z, Zhang Y, Han L, Shi L, Lin X. Trachea-derived dpp controls adult midgut homeostasis in Drosophila. Dev Cell. 2013;24:133-43 pubmed publisher
    ..This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication...
  8. Holzer P. TRP channels in the digestive system. Curr Pharm Biotechnol. 2011;12:24-34 pubmed
    ..Consequently, blockers of these TRP channels have been developed, and their clinical usefulness has yet to be established...
  9. Dinglasan R, Devenport M, Florens L, Johnson J, McHugh C, Donnelly Doman M, et al. The Anopheles gambiae adult midgut peritrophic matrix proteome. Insect Biochem Mol Biol. 2009;39:125-34 pubmed publisher
    ..Among them were nine new chitin-binding peritrophic matrix proteins, expanding the list from three to twelve peritrophins. Lastly, we provide a model for the putative interactions among the proteins identified in this study...
  10. Hödl E, Felder E, Chabicovsky M, Dallinger R. Cadmium stress stimulates tissue turnover in Helix pomatia: increasing cell proliferation from metal tolerance to exhaustion in molluscan midgut gland. Cell Tissue Res. 2010;341:159-71 pubmed publisher
    ..8 micromol Cd/g dry weight in the midgut gland of H. pomatia. At these Cd concentrations, Cd-MT was saturated with Cd(2+) ions, whereas at the cellular level, structural alterations turned into pathological deterioration...
  11. Del Pozo J, Turnbull J, Ferguson H, Crumlish M. A comparative molecular study of the presence of "Candidatus arthromitus" in the digestive system of rainbow trout, Oncorhynchus mykiss (Walbaum), healthy and affected with rainbow trout gastroenteritis. J Fish Dis. 2010;33:241-50 pubmed publisher
    ..The results of this study showed that the presence of SFB was not invariably associated with clinical disease and that more information is required to understand the role of these organisms...
  12. Prado S, Hung K, Daugherty M, Almeida R. Indirect effects of temperature on stink bug fitness, via maintenance of gut-associated symbionts. Appl Environ Microbiol. 2010;76:1261-6 pubmed publisher
    ..This work illustrates the need to better understand the biology of animal-symbiont associations and the consequences of local climate for the dynamics of these interactions...
  13. Zhang A, Li X, Jiang C, Lin L, Shi R, Chen J, et al. Expression of nesfatin-1/NUCB2 in rodent digestive system. World J Gastroenterol. 2010;16:1735-41 pubmed
    To observe the regional distributions and morphological features of nesfatin-1/nucleobindin-2 (NUCB2) immunoreactive (IR) cells in the rodent digestive system.
  14. Veenstra J, Agricola H, Sellami A. Regulatory peptides in fruit fly midgut. Cell Tissue Res. 2008;334:499-516 pubmed publisher
    ..Although the Drosophila insulin gene Ilp3 was abundantly expressed in the midgut, Ilp3 was not expressed in endocrine cells, but in midgut muscle...
  15. Filimonova S. The ultrastructural investigation of the midgut in the quill mite Syringophilopsis fringilla (Acari, Trombidiformes: Syringophilidae). Arthropod Struct Dev. 2009;38:303-13 pubmed publisher
    ..Evacuation of the fecal masses occurs periodically. Mitotic figures have been observed occasionally in the epithelial cells of the anterior midgut...
  16. Goss A, Tian Y, Tsukiyama T, Cohen E, Zhou D, Lu M, et al. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 2009;17:290-8 pubmed publisher
    ..Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut...
  17. Klann A, Alberti G. Histological and ultrastructural characterization of the alimentary system of solifuges (Arachnida, Solifugae). J Morphol. 2010;271:225-43 pubmed publisher
    ..In contrast to the midgut, the epithelium of the hindgut consists of only one type of cell overlain by a thin cuticle. Digested residuals are stored in the hindgut until defecation...
  18. Canesi L, Borghi C, Ciacci C, Fabbri R, Lorusso L, Vergani L, et al. Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland. Aquat Toxicol. 2008;87:272-9 pubmed publisher
    ..The results demonstrate that short-term exposure to environmentally relevant concentrations of EDC mixtures can interfere with the lysosomal function, redox-related enzyme activities and gene transcription of mussel digestive gland...
  19. Jeffers L, Michael Roe R. The movement of proteins across the insect and tick digestive system. J Insect Physiol. 2008;54:319-32 pubmed publisher
    The movement of intact proteins across the digestive system was shown in a number of different blood-feeding and non-blood-feeding insects in the orders Blattaria, Coleoptera, Diptera, Hemiptera, Lepidoptera, Orthoptera, Neuroptera and ..
  20. Andert J, Marten A, Brandl R, Brune A. Inter- and intraspecific comparison of the bacterial assemblages in the hindgut of humivorous scarab beetle larvae (Pachnoda spp.). FEMS Microbiol Ecol. 2010;74:439-49 pubmed publisher
    ..A comparison with a previously obtained clone library of the same species corroborates both the similarities and the intraspecific variance of the hindgut microbiota...
  21. Yee N, Gong W, Huang Y, Lorent K, Dolan A, Maraia R, et al. Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biol. 2007;5:e312 pubmed
    ..These data show that functional interactions between Pol III subunits have been conserved during eukaryotic evolution and support the utility of zebrafish as a model vertebrate for analysis of Pol III function...
  22. Dong Y, Manfredini F, Dimopoulos G. Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog. 2009;5:e1000423 pubmed publisher
    ..We show that the microbiota can modulate the anti-Plasmodium effects of some immune genes. In sum, the microbiota plays an essential role in modulating the mosquito's capacity to sustain Plasmodium infection...
  23. Azevedo D, Neves C, Mallet J, Gonçalves T, Zanuncio J, Serrão J. Notes on midgut ultrastructure of cimex hemipterus (Hemiptera: Cimicidae). J Med Entomol. 2009;46:435-41 pubmed
    ..Also, there was strong evidence that the posterior midgut may be the major site of nutrient absorption. The hematophagous heteropteran groups share many of these blood digestion mechanisms...
  24. Visôtto L, Oliveira M, Guedes R, Ribon A, Good God P. Contribution of gut bacteria to digestion and development of the velvetbean caterpillar, Anticarsia gemmatalis. J Insect Physiol. 2009;55:185-91 pubmed publisher
  25. Crotti E, Rizzi A, Chouaia B, Ricci I, Favia G, Alma A, et al. Acetic acid bacteria, newly emerging symbionts of insects. Appl Environ Microbiol. 2010;76:6963-70 pubmed publisher
    ..Taken together, the data indicate that AAB represent novel secondary symbionts of insects...
  26. Canesi L, Barmo C, Fabbri R, Ciacci C, Vergani L, Roch P, et al. Effects of vibrio challenge on digestive gland biomarkers and antioxidant gene expression in Mytilus galloprovincialis. Comp Biochem Physiol C Toxicol Pharmacol. 2010;152:399-406 pubmed publisher
    ..Moreover, the results support the hypothesis that host responses to bacteria may be taken into account when interpreting biomarker data in ecotoxicological studies...
  27. Haselton A, Yin C, Stoffolano J. FMRFamide-like immunoreactivity in the central nervous system and alimentary tract of the non-hematophagous blow fly, Phormia regina, and the hematophagous horse fly, Tabanus nigrovittatus. J Insect Sci. 2008;8:1-17 pubmed publisher
  28. Wang Z, Wang W, Qiu W, Fan Y, Zhao J, Wang Y, et al. Involvement of ghrelin-growth hormone secretagogue receptor system in pathoclinical profiles of digestive system cancer. Acta Biochim Biophys Sin (Shanghai). 2007;39:992-8 pubmed
    ..For the first time, we identified the distribution of ghrelin receptor in digestive system cancers...
  29. Kumar S, Molina Cruz A, Gupta L, Rodrigues J, Barillas Mury C. A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae. Science. 2010;327:1644-8 pubmed publisher
    ..Disruption of this barrier results in strong and effective pathogen-specific immune responses. ..
  30. Yoshida S, Shimada Y, Kondoh D, Kouzuma Y, Ghosh A, Jacobs Lorena M, et al. Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development. PLoS Pathog. 2007;3:e192 pubmed
  31. Filimonova S. The fine structure of the midgut in the mite Anystis baccarum (L.) (Acari, Actinedida: Anystidae). Arthropod Struct Dev. 2008;37:299-309 pubmed publisher
    ..All types of secretory granules were observed close to the apical plasmalemma...
  32. Olofsson T, Vásquez A. Detection and identification of a novel lactic acid bacterial flora within the honey stomach of the honeybee Apis mellifera. Curr Microbiol. 2008;57:356-63 pubmed publisher
  33. Coates B, Sumerford D, Hellmich R, Lewis L. Mining an Ostrinia nubilalis midgut expressed sequence tag (EST) library for candidate genes and single nucleotide polymorphisms (SNPs). Insect Mol Biol. 2008;17:607-20 pubmed publisher
    ..This O. nubilalis larval midgut EST collection is a resource for gene discovery, expression information, and allelic variation for use in genetic marker development...
  34. Trotter A, Parslow A, Heath J. Morphologic analysis of the zebrafish digestive system. Methods Mol Biol. 2009;546:289-315 pubmed publisher
    ..Despite optical transparency of embryos, the internal position of the developing digestive system and its close juxtaposition with the yolk initially made morphological analysis relatively challenging, ..
  35. Brackney D, Isoe J, W C B, Zamora J, Foy B, Miesfeld R, et al. Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. J Insect Physiol. 2010;56:736-44 pubmed publisher
    ..A subfamily of midgut serine proteases and/or that A. aegypti has evolved an array of proteases with a broad range of substrate specificities for rapid, efficient digestion of bloodmeals...
  36. Nardi J, Bee C, Miller L. Stem cells of the beetle midgut epithelium. J Insect Physiol. 2010;56:296-303 pubmed publisher
    ..This organization of stem cell pouches in insect midguts closely parallels that of regenerative crypts in mammalian intestines...
  37. Ostaszewska T, Kamaszewski M, Grochowski P, Dabrowski K, Verri T, Aksakal E, et al. The effect of peptide absorption on PepT1 gene expression and digestive system hormones in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol A Mol Integr Physiol. 2010;155:107-14 pubmed publisher
    ..Leptin immunoreactivity was also observed in hepatocyte cytoplasm and pancreatic acinar cells. Gastrin/CCK immunoreactive cells were present in the proximal intestine and pyloric caeca...
  38. Secundino N, Kimblin N, Peters N, Lawyer P, Capul A, Beverley S, et al. Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies. Cell Microbiol. 2010;12:906-18 pubmed publisher
  39. Neira Oviedo M, VanEkeris L, Corena McLeod M, Linser P. A microarray-based analysis of transcriptional compartmentalization in the alimentary canal of Anopheles gambiae (Diptera: Culicidae) larvae. Insect Mol Biol. 2008;17:61-72 pubmed publisher
    ..Furthermore, our data support the notion that the region encompassing the hindgut and Malpighian tubes plays important roles in avoiding the excretion of nutrients, as well as in xenobiotic detoxification...
  40. Enache Angoulvant A, Bourget M, Brisse S, Stockman Pannier C, Diancourt L, Francois N, et al. Multilocus microsatellite markers for molecular typing of Candida glabrata: application to analysis of genetic relationships between bloodstream and digestive system isolates. J Clin Microbiol. 2010;48:4028-34 pubmed publisher
    ..The demonstration of the occurrence of microevolution in digestive strains supports the idea that C. glabrata can be a persistent commensal of the human gut...
  41. Kang M, Mott T, Tapley E, Lewis E, Luckhart S. Insulin regulates aging and oxidative stress in Anopheles stephensi. J Exp Biol. 2008;211:741-8 pubmed publisher
  42. Dai W, Du H, Fu L, Jin C, Xu Z, Liu H. Effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in the digestive system of tilapia (Oreochromis niloticus). Biol Trace Elem Res. 2009;127:124-31 pubmed publisher
    ..the effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in tissues of the digestive system. The results showed that the Pb accumulation in tissues increased with the dietary Pb concentrations...
  43. Rost Roszkowska M, Jansta P, Vilimova J. Fine structure of the midgut epithelium in two Archaeognatha, Lepismachilis notata and Machilis hrabei (Insecta), in relation to its degeneration and regeneration. Protoplasma. 2010;247:91-101 pubmed publisher
    ..Some of them proliferate, while the others differentiate into epithelial cells. We compared the organisation of the midgut epithelium of M. hrabei and L. notata with zygentoman species, which have just been described...
  44. Rost Roszkowska M, Poprawa I, Wójtowicz M, Kaczmarek L. Ultrastructural changes of the midgut epithelium in Isohypsibius granulifer granulifer Thulin, 1928 (Tardigrada: Eutardigrada) during oogenesis. Protoplasma. 2011;248:405-14 pubmed publisher
    ..At the end of oogenesis, autophagy also intensifies in midgut epithelial cells, which is probably caused by the great amount of reserve material. Midgut epithelium of analyzed species takes part in the yolk precursor synthesis...
  45. Mendes A, Schlegelmilch T, Cohuet A, Awono Ambene P, De Iorio M, Fontenille D, et al. Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. PLoS Pathog. 2008;4:e1000069 pubmed publisher
    ..falciparum field isolates have been established by direct experimentation. Importantly, they validate for semi-field human malaria transmission the concept of parasite antagonists and agonists...
  46. Angelucci C, Barrett Wilt G, Hunt D, Akhurst R, East P, Gordon K, et al. Diversity of aminopeptidases, derived from four lepidopteran gene duplications, and polycalins expressed in the midgut of Helicoverpa armigera: identification of proteins binding the delta-endotoxin, Cry1Ac of Bacillus thuringiensis. Insect Biochem Mol Biol. 2008;38:685-96 pubmed publisher
    ..This is the first report of hybrid, lipocalin-like domains in shorter polycalin sequences that are not present in the longest sequence. We propose that these hybrid domains are generated by alternative splicing of the mRNA...
  47. Xia J, Liu J, Zhou L, Li Z, Gui J. Apo-14 is required for digestive system organogenesis during fish embryogenesis and larval development. Int J Dev Biol. 2008;52:1089-98 pubmed publisher
    ..in the yolk syncytial layer at a high level during embryogenesis, and then found to be restricted to the digestive system including liver and intestine in later embryos and early larvae...
  48. Rodrigues J, Brayner F, Alves L, Dixit R, Barillas Mury C. Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes. Science. 2010;329:1353-5 pubmed publisher
    ..In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory...
  49. Popova Butler A, Dean D. Proteomic analysis of the mosquito Aedes aegypti midgut brush border membrane vesicles. J Insect Physiol. 2009;55:264-72 pubmed publisher
    ..Three proteins, arginine kinase, putative allergen and actin are shown to be the most predominant proteins in the sample. The total number of 36 proteins detected by both methods represents the most abundant proteins in the BBMV...
  50. Sabbatini M. Natriuretic peptides as regulatory mediators of secretory activity in the digestive system. Regul Pept. 2009;154:5-15 pubmed publisher
    ..Overall, these findings indicate that ANP and CNP are members of the large group of regulatory peptides affecting digestive secretions...
  51. González Lázaro M, Dinglasan R, Hernández Hernández F, RODRIGUEZ M, Laclaustra M, Jacobs Lorena M, et al. Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei. Insect Biochem Mol Biol. 2009;39:395-402 pubmed publisher
    ..Interestingly, knockdown of SCRBQ2 expression by dsRNA injection resulted in a 62.5% inhibition of oocyst formation, suggesting that SCRBQ2 plays a role in Plasmodium-mosquito interactions. ..
  52. Rani A, Sharma A, Rajagopal R, Adak T, Bhatnagar R. Bacterial diversity analysis of larvae and adult midgut microflora using culture-dependent and culture-independent methods in lab-reared and field-collected Anopheles stephensi-an Asian malarial vector. BMC Microbiol. 2009;9:96 pubmed publisher
  53. Momota R, Naito I, Ninomiya Y, Ohtsuka A. Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. Matrix Biol. 2011;30:258-66 pubmed publisher