hemoperfusion

Summary

Summary: Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).

Top Publications

  1. ncbi Extracorporeal endotoxin removal for the treatment of sepsis: endotoxin adsorption cartridge (Toraymyxin)
    Hisataka Shoji
    Division of Planning and Science, Department of Blood Purification Medical Devices, Toray Medical Co, Tokyo, Japan
    Ther Apher Dial 7:108-14. 2003
  2. ncbi [Basics of hemoadsorption]
    Masaki Nakane
    Department of Anesthesiology, Fukushima Medical University School of Medicine
    Nihon Rinsho 62:22-8. 2004
  3. pmc Comparison between kidney and hemoperfusion for paraquat elimination
    Moon Soo Kang
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    J Korean Med Sci 24:S156-60. 2009
  4. doi Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock
    Chieko Mitaka
    Department of Critical Care Medicine, Tokyo Medical and Dental University Graduate School, Japan
    Shock 36:332-8. 2011
  5. ncbi In vitro evaluation of dextran sulfate cellulose beads for whole blood infusion low-density lipoprotein-hemoperfusion
    Akira Kobayashi
    Kaneka Corporation, Medical Devices Research Group, Medical Devices Division, Osaka, Japan
    Ther Apher 6:365-71. 2002
  6. ncbi [Paraquat poisoning and hemoperfusion with activated charcoal]
    A M López Lago
    Servicio de Medicina Intensiva, Hospital Clinico Universitario de Santiago de Compostela
    An Med Interna 19:310-2. 2002
  7. doi Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia-reperfusion injury in rats
    Tetsu Yamamoto
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Izumo, Japan
    Crit Care Med 38:879-85. 2010
  8. pmc The place of early haemoperfusion with polymyxin B fibre column in the treatment of sepsis
    Claudio Ronco
    Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy
    Crit Care 9:631-3. 2005
  9. ncbi The isolated perfused bovine uterus as a model for mucous membrane irritation and inflammation
    Wolfgang Baumer
    Institut fur Pharmakologie, Toxikologie und Pharmazie, Tierarztliche Hochschule Hannover, D Hannover, Germany
    ALTEX 19:57-63. 2002
  10. ncbi [Hemoperfusion in the treatment of acute valproic acid intoxication]
    R Peces
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Nefrologia 27:370-3. 2007

Research Grants

  1. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
  2. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
  3. POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHY
    JEAN FRECHET; Fiscal Year: 1993
  4. DESIGN OF MATERIAL FOR REMOVAL OF BLOOD TOXIC AGENTS
    DENNIS MC CARTHY; Fiscal Year: 1990
  5. PHENCYCLIDINE DISPOSITION KINETICS
    Michael Mayersohn; Fiscal Year: 1980
  6. MEMBRANE-MEDIATED SORPTIVE HEMOPERFUSION
    Edward Davis; Fiscal Year: 2000
  7. MEMBRANE-MEDIATED SORPTIVE HEMOPERFUSION
    DANIEL RUDOLPH; Fiscal Year: 1999
  8. A MINIATURIZED CARBON-FIBER HEMOPERFUSION DEVICE
    DONALD COWSAR; Fiscal Year: 1980
  9. EX VIVO IMMUNOALTERATION OF PANCREAS ORGAN TRANSPLANTS
    JAMES THISTLETHWAITE; Fiscal Year: 1990
  10. MethLock vs. heparin as dialysis catheter lock
    Stephen Ash; Fiscal Year: 2007

Detail Information

Publications187 found, 100 shown here

  1. ncbi Extracorporeal endotoxin removal for the treatment of sepsis: endotoxin adsorption cartridge (Toraymyxin)
    Hisataka Shoji
    Division of Planning and Science, Department of Blood Purification Medical Devices, Toray Medical Co, Tokyo, Japan
    Ther Apher Dial 7:108-14. 2003
    ..Further studies are now ongoing to establish Toraymyxin treatment as one of the options to treat sepsis and septic shock patients and to clarify the mechanisms involved in this therapy...
  2. ncbi [Basics of hemoadsorption]
    Masaki Nakane
    Department of Anesthesiology, Fukushima Medical University School of Medicine
    Nihon Rinsho 62:22-8. 2004
  3. pmc Comparison between kidney and hemoperfusion for paraquat elimination
    Moon Soo Kang
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    J Korean Med Sci 24:S156-60. 2009
    ..This study is designed to compare the efficacy of PQ elimination with hemoperfusion (HP) and kidneys, taking into account the functional deterioration of the kidneys...
  4. doi Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock
    Chieko Mitaka
    Department of Critical Care Medicine, Tokyo Medical and Dental University Graduate School, Japan
    Shock 36:332-8. 2011
    ..Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994...
  5. ncbi In vitro evaluation of dextran sulfate cellulose beads for whole blood infusion low-density lipoprotein-hemoperfusion
    Akira Kobayashi
    Kaneka Corporation, Medical Devices Research Group, Medical Devices Division, Osaka, Japan
    Ther Apher 6:365-71. 2002
    ..of a newly developed low-density lipoprotein (LDL) adsorbent designed for use in whole-blood infusion LDL-hemoperfusion. The adsorbent has almost the same chemical structure as the Liposorber adsorbent (dextran sulfate cellulose ..
  6. ncbi [Paraquat poisoning and hemoperfusion with activated charcoal]
    A M López Lago
    Servicio de Medicina Intensiva, Hospital Clinico Universitario de Santiago de Compostela
    An Med Interna 19:310-2. 2002
    ..with orogastric lavage, activated charcoal, N-acetylcysteine, Fuller's earth, cathartics, support measures and hemoperfusion with activated charcoal...
  7. doi Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia-reperfusion injury in rats
    Tetsu Yamamoto
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Izumo, Japan
    Crit Care Med 38:879-85. 2010
    ....
  8. pmc The place of early haemoperfusion with polymyxin B fibre column in the treatment of sepsis
    Claudio Ronco
    Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy
    Crit Care 9:631-3. 2005
    ..This commentary considers whether the available evidence allows us to establish an appropriate role for PMX-F treatment in sepsis and what further work is needed...
  9. ncbi The isolated perfused bovine uterus as a model for mucous membrane irritation and inflammation
    Wolfgang Baumer
    Institut fur Pharmakologie, Toxikologie und Pharmazie, Tierarztliche Hochschule Hannover, D Hannover, Germany
    ALTEX 19:57-63. 2002
    ..In conclusion, the isolated perfused bovine uterus seems to be a promising in vitro model for mucous membrane irritancy as well as for inflammatory reactions...
  10. ncbi [Hemoperfusion in the treatment of acute valproic acid intoxication]
    R Peces
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Nefrologia 27:370-3. 2007
    ..and saturable protein-binding render it potentially amenable to exracorporeal removal (hemodialysis, hemoperfusion or hemofiltration ), but published experience is scarce...
  11. ncbi A case of successful treatment with polymyxin B-immobilized fiber column direct hemoperfusion in acute respiratory distress syndrome after influenza A infection
    Kazuhiro Yatera
    Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan
    Intern Med 50:601-5. 2011
    ..ARDS) after influenza A infection who was successfully treated with combined treatment including direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) column...
  12. doi A case of severe ARDS caused by novel swine-origin influenza (A/H1N1pdm) virus: a successful treatment with direct hemoperfusion with polymyxin B-immobilized fiber
    Toshiki Yokoyama
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano 390 8621, Japan
    J Clin Apher 25:350-3. 2010
    ..We subsequently treated the patient with direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP). The hypoxemia improved immediately...
  13. ncbi Continuous arteriovenous hemoperfusion in acute poisoning
    J L Lin
    Division of Nephrology and Poison Center, Chang Gung Memorial Hospital, Chang Gung Medical College, Lin Kou Medical Center, Taipei, Taiwan, ROC
    Blood Purif 12:121-7. 1994
    We have investigated the efficacy of a pumpless hemoperfusion technique, continuous arteriovenous hemoperfusion (CAVHP) in 3 cases of acute intoxications with meprobamate, theophylline and phenobarbital...
  14. ncbi Is there a role for hemoperfusion/hemodialysis as a treatment option in severe tricyclic antidepressant intoxication?
    R D Frank
    Medizinische Klinik II, Universitätsklinikum der RWTH Aachen, Germany
    Int J Artif Organs 23:618-23. 2000
    ..The role of extracorporeal, treatment procedures is not clear. The possible benefit of hemoperfusion/hemodialysis is discussed in a case report with respect to the published literature.
  15. doi Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    Shock 31:454-9. 2009
    ..in patients with septic shock or severe sepsis without shock and whether polymyxin B-immobilized fiber (PMX-F) hemoperfusion affects these levels...
  16. ncbi Effect of direct hemoperfusion with a polymyxin B immobilized fiber column on high mobility group box-1 (HMGB-1) in severe septic shock: report of a case
    Yuichiro Sakamoto
    Department of Emergency and Critical Care Medicine, Chiba Hokisou Hospital, Nippon Medical School, Inba gun, Chiba, Japan
    ASAIO J 52:e37-9. 2006
    ..Our patient, however, recovered from severe septic shock and was saved by the use of direct hemoperfusion with a polymyxin B immobilized fiber column (DHP-PMX)...
  17. ncbi Hemoperfusion in a child with amitriptyline intoxication
    Osman Donmez
    Department of Pediatric Nephrology, Faculty of Medicine, Uludag University, Bursa, Turkey
    Pediatr Nephrol 20:105-7. 2005
    ..b>Hemoperfusion (HP) was performed for 2 h...
  18. ncbi Effect of polymyxin B-immobilized fiber hemoperfusion on serum high mobility group box-1 protein levels and oxidative stress in patients with acute respiratory distress syndrome
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    ASAIO J 55:395-9. 2009
    ..Polymyxin B-immobilized fiber (PMX-F) hemoperfusion is effective for sepsis-induced ARDS...
  19. ncbi High-flux hemodialysis--an effective alternative to hemoperfusion in the treatment of carbamazepine intoxication
    J T Kielstein
    Division of Nephrology, Medical School, Hanover, Germany
    Clin Nephrol 57:484-6. 2002
    ..In acute intoxication, charcoal hemoperfusion is employed for removal of the drug...
  20. doi Angiopoietin balance in septic shock patients with acute lung injury: effect of direct hemoperfusion with polymyxin B-immobilized fiber
    Itaru Ebihara
    Department of Nephrology, Mito Saiseikai General Hospital, Mito, Japan
    Ther Apher Dial 15:349-54. 2011
    ..Polymyxin B-immobilized fiber column hemoperfusion is effective for sepsis-induced ALI...
  21. doi Efficacy of hemodialysis and charcoal hemoperfusion in carbamazepine overdose
    Maricel Pilapil
    Clin Toxicol (Phila) 46:342-3. 2008
  22. ncbi Low-density lipoprotein apheresis therapy with a direct hemoperfusion column: a Japanese multicenter clinical trial
    Hiromi Tasaki
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Ther Apher Dial 10:32-41. 2006
    ..We conclude that the new type of LDL adsorption column, one that deals with whole blood, is a promising apheresis therapy for FH patients in view of its efficacy, reduced time for treatment, and safety...
  23. doi Sustained low-efficiency daily diafiltration with hemoperfusion as a therapy for severe star fruit intoxication: a report of two cases
    Chia Lin Wu
    Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
    Ren Fail 33:837-41. 2011
    ..of choice for severe star fruit intoxication may be continuous renal replacement therapy with or without hemoperfusion. We report two cases of star fruit intoxication with stage V CKD (one case is predialysis) presenting with ..
  24. ncbi Hemodialysis is as effective as hemoperfusion for drug removal in carbamazepine poisoning
    Mihály Tapolyai
    Cleveland Clinic Florida, Fort Lauderdale, FL 33309, USA
    Nephron 90:213-5. 2002
    Although most authors recommend charcoal hemoperfusion (CHP) for the removal of carbamazepine (CBZ) in acute CBZ poisoning, we present a case where we had the chance to compare CHP with hemodialysis (HD)...
  25. doi Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial
    Dinna N Cruz
    Department of Nephrology, Dialysis, and Transplantation, St Bortolo Hospital and International Renal Research Institute Vicenza, 36100 Vicenza, Italy
    JAMA 301:2445-52. 2009
    ..Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin. Reducing circulating endotoxin levels with polymyxin B hemoperfusion could potentially improve patient clinical outcomes.
  26. ncbi Comparative efficacy of hemodialysis and hemoperfusion in severe theophylline intoxication
    M W Shannon
    Children s Hospital, Department of Pediatrics, Boston, MA 02115
    Acad Emerg Med 4:674-8. 1997
    To determine the comparative efficacy of hemoperfusion and hemodialysis for severe theophylline toxicity in concurrent case series.
  27. ncbi A novel adsorbent of circulating bacterial toxins and cytokines: the effect of direct hemoperfusion with CTR column for the treatment of experimental endotoxemia
    Takumi Taniguchi
    Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    Crit Care Med 34:800-6. 2006
    ....
  28. doi Use of hemodialysis and hemoperfusion in poisoned patients
    William J Holubek
    Department of Emergency Medicine, New York Methodist Hospital, New York, New York, USA
    Kidney Int 74:1327-34. 2008
    Extracorporeal removal techniques such as hemodialysis, charcoal hemoperfusion, and peritoneal dialysis have been used to remove toxins from the body...
  29. pmc Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors
    Vincenzo Cantaluppi
    Dipartimento di Medicina Interna, Centro Ricerca Medicina Sperimentale CeRMS, Torino, Italy
    Intensive Care Med 34:1638-45. 2008
    ..To test the hypothesis that extracorporeal therapy with polymyxin B (PMX-B) may prevent Gram-negative sepsis-induced acute renal failure (ARF) by reducing the activity of proapoptotic circulating factors...
  30. ncbi Direct hemoperfusion by using Lixelle column for the treatment of systemic inflammatory response syndrome
    Kenji Tsuchida
    Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Abeno Ku, Osaka City 545 8586, Japan
    Int J Mol Med 10:485-8. 2002
    ..The aim of this study was to estimate that an adsorbent column was used in direct hemoperfusion in patients clinically having systemic inflammatory response syndrome (SIRS), and the relationship between a ..
  31. doi Clinical outcome of hemoperfusion in poisoned patients
    Hyo Wook Gil
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea
    Blood Purif 30:84-8. 2010
    ..To define the safety and clinical outcomes of hemoperfusion, we evaluated retrospectively clinical outcomes of hemoperfusion over a 3-year period in our clinical center...
  32. ncbi Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    Am J Surg 188:150-6. 2004
    b>Hemoperfusion with PMX-F (polymyxin B covalently immobilized on fibers) has been reported to be safe and effective for patients with septic shock. However, the molecular mechanism of this usefulness is not yet clear...
  33. ncbi High-flux hemodialysis without hemoperfusion is effective in acute valproic acid overdose
    S L Kane
    College of Pharmacy, Ohio State University, Columbus 43210, USA
    Ann Pharmacother 34:1146-51. 2000
    To report a case of valproic acid overdose treated successfully with high-flux hemodialysis without the addition of charcoal hemoperfusion.
  34. ncbi Ex-vivo hemoperfusion (eHPS) of pig-lungs with whole human blood: effects of complement inhibition with a soluble C1-esterase-inhibitor
    H Schelzig
    University of Ulm, Dept of Thoracic and Vascular Surgery, Germany
    Ann Transplant 6:34-9. 2001
    ..We developed an ex-vivo hemoperfusion (EHP) system to investigate pathophysiology of HAR in the lung...
  35. ncbi Dose-related effects of direct hemoperfusion using a cytokine adsorbent column for the treatment of experimental endotoxemia
    Takumi Taniguchi
    Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, 920 8641, Kanazawa, Japan
    Intensive Care Med 33:529-33. 2007
    To clarify the dose-related effects of direct hemoperfusion using a cytokine adsorbent column (CTR) on the mortality and inflammatory responses to endotoxin-induced shock in rats.
  36. ncbi Arresting dialysis-related amyloidosis: a prospective multicenter controlled trial of direct hemoperfusion with a beta2-microglobulin adsorption column
    Fumitake Gejyo
    Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Artif Organs 28:371-80. 2004
    We investigated the clinical efficacy of direct hemoperfusion with a beta2-microglobulin (beta2-m) adsorption column for the treatment of patients with dialysis-related amyloidosis...
  37. ncbi Beneficial effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on acute exacerbation of idiopathic pulmonary fibrosis
    Yoshitsugu Seo
    4th Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8603, Japan
    Intern Med 45:1033-8. 2006
    This study was aimed to investigate the effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on the acute exacerbation of idiopathic pulmonary fibrosis (IPF).
  38. pmc Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Viale Rodolfi 37, 36100 Vicenza, Italy
    Crit Care 11:R47. 2007
    ..We performed a systematic review to describe the effect in septic patients of direct hemoperfusion with PMX-F on outcomes of blood pressure, use of vasoactive drugs, oxygenation, and mortality reported in ..
  39. ncbi Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis
    Shinji Kohro
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Anesth 20:11-6. 2006
    Direct hemoperfusion (DHP) with polymixin B-immobilized fiber (PMX) has been reported to be effective for patients with septic shock. The aim of this study was to clarify the mechanism of PMX-DHP effect on septic shock.
  40. ncbi Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+ CD14+ monocytes in patients with septic shock
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College Research Institute, Saitama, Japan
    J Endotoxin Res 10:229-37. 2004
    CD16+ CD14+ monocytes dramatically increase in number in patients with severe infection. Hemoperfusion with PMX-F (direct hemoperfusion with polymyxin B immobilized fibers) has been reported to be a safe and effective treatment for ..
  41. ncbi A novel immunotherapeutic modality with direct hemoperfusion targeting transforming growth factor-beta prolongs the survival of tumor-bearing rats
    Yoshiki Yamamoto
    Department of Surgery, Division of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Oncol Rep 16:1277-84. 2006
    ..from tumor-bearing hosts, we developed an immunosuppressive substance adsorption (ISA) column for direct hemoperfusion (DHP) treatment. It is filled with extra-fine fibers that can adsorb TGF-beta...
  42. ncbi Effect of haemoperfusion on plasma paraquat concentration in vitro and in vivo
    Sae Yong Hong
    Department of Internal Medicine and Clinical Research Institute, Soonchunhyang University College of Medicine, Cheonan, Korea
    Toxicol Ind Health 19:17-23. 2003
    ..3+/-19.9 versus 67.2+/-19.2%, P <0.01), we concluded that adequate HP appears to be an indispensable treatment for patients with acute PQ poisoning...
  43. ncbi A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 23:400-5. 2005
    Endotoxin is an important pathogenic trigger for sepsis. The polymyxin B-immobilized endotoxin removal hemoperfusion cartridge, Toraymyxin (hereafter PMX), has been shown to remove endotoxin in preclinical and open-label clinical studies...
  44. ncbi Effect of polymyxin B-immobilized fiber on blood metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in acute respiratory distress syndrome patients
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    Blood Purif 22:256-60. 2004
    ..We aimed to assess whether PMX-F treatment alters the blood MMP-9 and tissue inhibitor of MMP (TIMP)-1 levels in ARDS patients...
  45. ncbi In acute organophosphate poisoning, the efficacy of hemoperfusion on clinical status and mortality
    Levent Altintop
    Department of Internal Medicine, Ondokuz Mayis University, School of Medicine, Samsun, Turkey
    J Intensive Care Med 20:346-50. 2005
    ..to report experience in patients with organophosphate poisoning (OPP) and to discuss the potential role for hemoperfusion (HP) in the management of severe OPP...
  46. ncbi Direct hemoperfusion using a polymyxin B immobilized column improves acute respiratory distress syndrome
    Kenji Tsushima
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    J Clin Apher 17:97-102. 2002
    ..We have studied whether direct hemoperfusion using a polymyxin B immobilized fiber column (PMX-DHP) is effective for acute lung injury (ALI) and ARDS...
  47. doi Vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in septic shock patients treated with direct hemoperfusion with a polymyxin B-immobilized fiber column
    Itaru Ebihara
    Department of Nephrology, Mito Saiseikai General Hospital, Mito, Japan
    Ther Apher Dial 12:285-91. 2008
    ..Serum VEGF and soluble Flt-1 levels in 21 patients with septic shock, who were treated with direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX), were measured by enzyme-linked immunoassay...
  48. ncbi Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning
    Ja Ryong Koo
    Division of Nephrology, College of Medicine, Hallym University, Chunchon, Kangwon Do, Seoul, Korea
    Am J Kidney Dis 39:55-9. 2002
    ..The amount ingested was 2.1 +/- 1.0 mouthfuls (as 20% concentrate). All patients were treated with hemoperfusion (HP; duration, 6.4 +/- 3...
  49. ncbi Endotoxin adsorption by polymyxin B immobilized fiber column in patients with systemic inflammatory response syndrome: the Japanese experience
    Takashi Sato
    Kidney Center, Koga Hospital, Kurume, Fukuoka Japan
    Ther Apher Dial 7:252-8. 2003
    ..Further studies are needed to clarify the mechanisms of PMX treatment and to strengthen the scientific basis of this treatment...
  50. ncbi Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis
    H Nemoto
    Department of Nephrology and Kidney Disease Center, Saitama Medical College, Saitama, Japan
    Blood Purif 19:361-8; discussion 368-9. 2001
    ..However, in severe sepsis, this therapy does not improve the survival rate...
  51. doi Polymyxin B-immobilized fiber hemoperfusion attenuates increased plasma atrial natriuretic peptide and brain natriuretic Peptide levels in patients with septic shock
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    ASAIO J 54:210-3. 2008
    Polymyxin B-immobilized fiber (PMX-F) hemoperfusion is reported to be safe and effective in septic shock patients...
  52. doi Relationship between treatment resistance to hemoperfusion using a polymyxin B-immobilized fiber column and oxidative stress
    Yuichiro Sakamoto
    Department of Emergency and Critical Care Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Japan
    ASAIO J 54:412-5. 2008
    ..Recent reports have suggested that direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX) may improve the oxygenation in patients with acute lung ..
  53. ncbi Hemoperfusion with an immobilized polymyxin B fiber column inhibits activation of vascular endothelial cells
    Hidehiko Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    Ther Apher Dial 9:303-7. 2005
    ..We therefore investigated whether direct hemoperfusion (DHP) with a polymyxin B immobilized fiber column (PMX) could reduce the level of plasminogen activator ..
  54. ncbi Clinical evaluation of PMX-DHP for hypercytokinemia caused by septic multiple organ failure
    Toshiaki Ikeda
    Division of Critical Care and Emergency Medicine, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan
    Ther Apher Dial 8:293-8. 2004
    ..These results suggest that PMX-DHP could save more lives in patients with septic multiple organ failure with IL-6 = 1000 pg/mL when applied early after the onset of shock...
  55. ncbi Endotoxin removal by direct hemoperfusion with an adsorbent column using polymyxin B-immobilized fiber ameliorates systemic circulatory disturbance in patients with septic shock
    Kohei Uriu
    Kidney Center, First Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Kitakyusyu, Japan
    Am J Kidney Dis 39:937-47. 2002
    Direct hemoperfusion (DHP) with an adsorbent column using polymyxin B-immobilized fiber (PMX-F) has been shown to improve the state of shock in patients with septic shock...
  56. ncbi Hemoperfusion with polymyxin B immobilized fibers for urinary albumin excretion in septic patients with trauma
    Tsukasa Nakamura
    Department of Medicine, Misato Junshin Hospital, Saitama, Japan
    ASAIO J 48:244-8. 2002
    ..Plasma endotoxin levels were determined by endospecy test. Hemoperfusion with PMX-F was carried out twice, for 2 hours, at a flow rate of 100 ml/min...
  57. ncbi Endotoxin adsorption therapy for septic shock using polymyxin B-immobilized fibers (PMX): evaluation by high-sensitivity endotoxin assay and measurement of the cytokine production capacity
    Masahiro Kojika
    Department of Critical Care Medicine, Iwate Medical University, School of Medicine, Morioka, Japan
    Ther Apher Dial 10:12-8. 2006
    ..The 28-day mortality rate was 12%. PMX-direct hemoperfusion (PMX-DHP) was associated with elevation of the mean arterial pressure and urine output, reduction in the mean ..
  58. ncbi Hemoperfusion with an immobilized polymyxin B column reduces the blood level of neutrophil elastase
    Hidehiko Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    Blood Purif 24:212-7. 2006
    We investigated whether direct hemoperfusion with an immobilized polymyxin B column (DHP with PMX) could reduce the blood level of neutrophil elastase.
  59. ncbi The severity of hyperdynamic circulation may predict the effects of direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber in patients with gram-negative septic shock
    K Uriu
    Kidney Center, and Division of Critical Care Medicine, University of Occupational and Environmental Health School of Medicine, Kitakyusyu, Japan
    Ther Apher 5:25-30. 2001
    It has been reported that direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber (DHP with PMX-F column) ameliorates hyperdynamic circulation in septic shock and improves survival rate...
  60. pmc Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation
    Hidehiko Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo, 173 8610, Japan
    Crit Care 9:R653-61. 2005
    The objective of this study was to clarify the efficacy and mechanism of action of direct hemoperfusion with an immobilized polymyxin B fiber column (DHP-PMX) in patients with acute lung injury or acute respiratory distress syndrome ..
  61. ncbi Combination therapy with polymyxin B-immobilized fibre haemoperfusion and teicoplanin for sepsis due to methicillin-resistant Staphylococcus aureus
    T Nakamura
    Department of Medicine, Misato Junshin Hospital, Saitama, Japan
    J Hosp Infect 53:58-63. 2003
    ..001). The mean duration of stay was 44, 42, 28 and 56 days in groups A, B, C and D, respectively. Our data suggest that combination therapy with PMX-F and teicoplanin is effective for sepsis caused by MRSA...
  62. ncbi Hemoperfusion with polymyxin B-immobilized fiber in septic patients with methicillin-resistant Staphylococcus aureus-associated glomerulonephritis
    Tsukasa Nakamura
    Department of Medicine, Misato Junshin Hospital, Saitama, Japan
    Nephron Clin Pract 94:c33-9. 2003
    ....
  63. ncbi Therapeutic efficacy of charcoal hemoperfusion in patients with acute severe dichlorvos poisoning
    Ai Peng
    Department of Medicine, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, China
    Acta Pharmacol Sin 25:15-21. 2004
    To assess the efficacy of hemoperfusion (HP) in the treatment of the patients with acute severe dichlorvos (DDVP) poisoning.
  64. ncbi Polymyxin B-immobilized fiber hemoperfusion after emergency surgery in patients with chronic renal failure
    Tamotsu Tojimbara
    Department of Surgery III, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Ther Apher Dial 8:286-92. 2004
    The purpose of this study was to evaluate the effect of direct hemoperfusion using a Polymyxin B (PMX) immobilized fiber column in septic patients with chronic renal failure after emergency surgery...
  65. ncbi Effect over time of endotoxin adsorption therapy in sepsis
    Takuya Ueno
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Ther Apher Dial 9:128-36. 2005
    ..In recent years, endotoxin adsorption therapy (PMX-DHP, polymyxin-direct hemoperfusion) has been widely used in Japan to remove endotoxin, a causative agent of sepsis...
  66. ncbi Effects of polymyxin B-immobilized fiber hemoperfusion on amino acid imbalance in septic encephalopathy
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    Blood Purif 21:282-6. 2003
    ..study was to determine whether the ratio of branched-chain amino acids to aromatic amino acids is altered in patients with septic encephalopathy and whether polymyxin B-immobilized fiber (PMX-F) hemoperfusion affects this balance.
  67. ncbi Hemoadsorption in critical care
    Toshiaki Ikeda
    Division of Critical Care and Emergency Medicine, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan
    Ther Apher 6:189-92. 2002
    ..These results suggest favorable effects of endotoxin hemoadsorption on the hemodynamic and pathophysiological conditions in patients with septic shock although attention should be given to the decrease in platelet count...
  68. ncbi Endotoxin apheresis for sepsis
    Tomoharu Shimizu
    Department of Surgery, Shiga University of Medical Science, Shiga, Japan
    Transfus Apher Sci 35:271-82. 2006
    ..Lixelle and CTR which have recently been shown to remove circulating bacterial components are also included in this review...
  69. ncbi Physiological response to superantigen-adsorbing hemoperfusion in toxin-concentration-controlled septic swine
    Keishi Miwa
    New Frontiers Research Laboratories, Toray Industries, Inc, Kanagawa, Japan
    Blood Purif 24:319-26. 2006
    ..The effects of hemoadsorption with a superantigen-adsorbing device (SAAD) were evaluated in septic swine...
  70. pmc A targeted extracorporeal therapy for endotoxemia: the time has come
    John A Kellum
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 11:137. 2007
    ..High levels of endotoxin activity are associated with worse clinical outcomes. In Japan, polymyxin B hemoperfusion has been available to treat endotoxemia for more than ten years...
  71. ncbi Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock
    Yuichiro Sakamoto
    Department of Emergency and Critical Care Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Inba gun, Chiba, Japan
    ASAIO J 53:646-50. 2007
    Direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX; Toray Industries Inc., Tokyo, Japan) was first developed in 1994 and has since been used for the treatment of septic shock...
  72. ncbi Clinical effects of direct hemoperfusion using a polymyxin-B immobilized column in solid organ transplanted patients with signs of severe sepsis and septic shock. A pilot study
    F Ruberto
    Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy
    Int J Artif Organs 30:915-22. 2007
    ..An extracorporeal hemoperfusion device (TORAYMYXIN) has been developed: PMX is covalently bound on the surface of an insoluble carrier ..
  73. ncbi Endotoxin removal with a polymyxin B-immobilized hemoperfusion cartridge improves cardiopulmonary function after cardiopulmonary bypass
    Shigeru Ohki
    Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma, Japan
    J Surg Res 145:74-9. 2008
    ..We evaluated the effectiveness of endotoxin removal with a polymyxin B-immobilized hemoperfusion cartridge (PMX) in CPB.
  74. ncbi Clinical effects of use polymyxin B fixed on fibers in liver transplant patients with severe sepsis or septic shock
    F Ruberto
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Transplant Proc 39:1953-5. 2007
    ..An extracorporeal hemoperfusion device (TORAYMYXIN) has been developed: PMX is covalently bound to the surface of an insoluble carrier ..
  75. ncbi Clinical effects of polymyxin B-immobilized fiber column in septic patients
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Vicenza, Italy
    Contrib Nephrol 156:444-51. 2007
    ..Direct hemoperfusion with polymyxin-B-immobilized fiber (PMX-F) is a promising treatment of gram-negative sepsis in critically ill ..
  76. ncbi The effect of continuous veno-venous hemofiltration or direct hemoperfusion with polymyxin B-immobilized fiber on neutrophil respiratory oxidative burst in patients with sepsis and septic shock
    Toshio Naka
    Department of Critical Care Medicine, Wakayama Medical University, Wakayama, Japan
    Ther Apher Dial 10:7-11. 2006
    ..Blood purification therapies such as continuous veno-venous hemofiltration (CVVH) and direct hemoperfusion with polymyxin-immobilized fiber (PMX-DHP) have been used for the treatment of sepsis and septic shock, ..
  77. ncbi Polymyxin B-immobilized fiber hemoperfusion with the PMX-05R column in elderly patients suffering from septic shock
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    Am J Med Sci 334:244-7. 2007
    Direct hemoperfusion with the polymyxin B-immobilized fiber (PMX-20R) column has a positive effect on outcome in patients with sepsis or septic shock...
  78. ncbi Intraoperative endotoxin adsorption as a new therapeutic option for mycotic aortic aneurysm
    Toshinori Totsugawa
    Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan
    Circ J 72:161-3. 2008
    ..Direct hemoperfusion using polymyxin B-immobilized fiber (PMX-DHP) was intraoperatively carried out in parallel with the ..
  79. ncbi Blood purification therapy for sepsis
    Hiromi Sakata
    Department of Surgery, Sapporo Hokuyu Hospital, Research Institute for Artificial Organs, Transplantation and Gene Therapy, 6 6 5 1, Higashi Sapporo, Shiroishi ku, Sapporo, Hokkaido 003 0006, Japan
    Transfus Apher Sci 35:245-51. 2006
    ..Blood purification therapy including polymyxin B-immobilized hemoperfusion cartridge and continuous hemodiafiltration has shown the beneficial effect on patients with sepsis in Japan...
  80. ncbi Hemoperfusion with an immobilized polymyxin B fiber column reduces circulating interleukin-8 concentrations
    Hidehiko Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    Ther Apher Dial 10:425-9. 2006
    In the present study, we examined whether the performance of hemoperfusion with an immobilized polymyxin B fiber column (DHP-PMX) reduces circulating interleukin-8 concentration in patients with sepsis...
  81. ncbi Effects of combination therapy with direct hemoperfusion using polymyxin B-immobilized fiber and oral vancomycin on fulminant pseudomembranous colitis with septic shock
    Yoshihide Kimura
    Department of Internal Medicine, Nagoya City Johoku Hospital, 2 15 Kaneda cho, Kita ku, Nagoya 462 0033, Japan
    Dig Dis Sci 52:675-8. 2007
    ..Direct hemoperfusion using polymyxin B-immobilized fiber, which was previously demonstrated to have excellent therapeutic effects ..
  82. ncbi Effects of PMX-DHP treatment for patients with directly induced acute respiratory distress syndrome
    Kenji Tsushima
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Ther Apher Dial 11:138-45. 2007
    Endotoxin-removal direct hemoperfusion column containing polymyxin B immobilized fibers (PMX-DHP) is an effective procedure for the treatment of sepsis-induced acute respiratory distress syndrome (ARDS)...
  83. doi Early hemoperfusion with a polymyxin b column improves gastric intramucosal pH in sepsis
    Hidehiko Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    Ther Apher Dial 12:278-84. 2008
    ..The other was to determine whether direct hemoperfusion with a polymyxin B fiber column (DHP-PMX) could improve the pHi if it remained low after early goal-directed ..
  84. ncbi [Polymyxin-B direct hemoperfusion (PMX-DHP) in gram negative sepsis]
    A F Perego
    A O Ospedale Niguarda Ca, Granda, Milano
    G Ital Nefrol 23:S94-102. 2006
    ..The polymyxin B cartridge is an extracorporeal hemoperfusion device (PMX-DHP) known to remove circulating endotoxins...
  85. ncbi [Experimental study on a novel affinity adsorbent for removal of endotoxin in plasma]
    Yuan Li
    Key Lab for Biomechanical and Tissue Engineering under the State Ministry of Education, Chongqing University, Chongqing 400044, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:832-5. 2006
    ..The rat models of endotoxemia were established, which were used in hemoperfusion. The experiment results indicated that the novel affinity adsorbent could remove endotoxin from plasma ..
  86. doi Criteria for direct hemoperfusion with an immobilized polymyxin B fiber column based on oxygen metabolism
    Hidehiko Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    Ther Apher Dial 12:292-7. 2008
    The optimum time for commencement of direct hemoperfusion with a polymyxin B immobilized fiber column (DHP-PMX) in patients with sepsis remains unclear...
  87. ncbi Relationship between effect of polymyxin B-immobilized fiber and high-mobility group box-1 protein in septic shock patients
    Yuichiro Sakamoto
    Department of Emergency and Critical Care Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan
    ASAIO J 53:324-8. 2007
    Direct hemoperfusion (DHP) using a polymyxin B (PMX)-immobilized fiber column has been used for treatment of endotoxemia-induced septic shock in Japan since 1994 and is now an accepted therapy for reducing serum endotoxin levels...
  88. ncbi Emerging technologies in extracorporeal treatment: focus on adsorption
    Sergey V Mikhalovsky
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK
    Perfusion 18:47-54. 2003
    ..Since the 1990s interest in the use of adsorbents in extracorporeal medical devices has been rising again. In this paper some recent developments in synthesis and application of novel uncoated medical adsorbents are discussed...
  89. ncbi [Experience of direct hemoperfusion using polymyxin B-immobilized fiber on patients with endotoxin shock from urosepsis]
    H Ushida
    Department of Urology, Uji Tokushukai Hospital
    Hinyokika Kiyo 47:329-31. 2001
    We report the effects of direct hemoperfusion using polymyxin B-immobilized fiber (PMX treatment) on two patients with endotoxin shock from urosepsis...
  90. ncbi Changes in circulating levels of calcitonin gene-related peptide and nitric oxide metabolites in septic patients during direct hemoperfusion with polymyxin B-immobilized fiber
    Tomoharu Shimizu
    PMX Hemodynamics Study Group, Shiga University of Medical Science, Shiga, Japan
    Blood Purif 21:237-43. 2003
    ..This study evaluated the mechanism of hemodynamic improvement in polymyxin B-immobilized fiber (PMX) treatment...
  91. ncbi [Clinical experiences of endotoxin removal in urinary obstruction: report of two cases]
    Motohiko Sugi
    Department of Urology, Iseikai Hospital
    Hinyokika Kiyo 50:685-9. 2004
    ..Under the diagnosis of septic shock, left nephrostomy were performed. Direct hemoperfusion using polymyxin B immobilized fiber column was carried out...
  92. ncbi Selection of hemoperfusion therapy for patients with septic shock on the basis of the primary disease
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    J Artif Organs 6:205-10. 2003
    ..There were no significant differences between the two groups in age or the Apache II scores at the start of hemoperfusion treatment; however, the gender ratio varied: 72% of the cardiovascular group were male, compared to 46% of the ..
  93. ncbi Extracorporeal endotoxin adsorption in septic patients--does it work?
    Guido Grass
    Crit Care Med 32:1792-3. 2004
  94. ncbi Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis
    Konrad Reinhart
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, 07743 Jena, Germany
    Crit Care Med 32:1662-8. 2004
    ..An initial phase II trial to investigate the safety and therapeutic effect of the endotoxin adsorber system EN 500 in septic patients suffering from presumed Gram-negative infection...
  95. ncbi [Hemoperfusion]
    Shigeo Negi
    Center of Blood Purification Therapy, Wakayama Medical University
    Nihon Rinsho 62:343-6. 2004
  96. ncbi Changes of cytokines in direct endotoxin adsorption treatment on postoperative multiple organ failure
    N Matsuno
    Fifth Department of Surgery, Hachioji Medical Center, Tokyo Medical University, Hachioji-city, Japan
    Ther Apher 5:36-9. 2001
    ..therapy with the endotoxin adsorption column containing polymyxin B immobilized fibers by direct hemoperfusion (PMX-DHP) is reportedly effective in the treatment of septic shock...
  97. ncbi A new therapeutic strategy for streptococcal toxic shock syndrome: a key target for cytokines
    Takayuki Kawaguchi
    Department of Internal Medicine, Takasago Municipal Hospital, Takasago
    Intern Med 42:211-8. 2003
    ..Direct hemoperfusion with polymyxin B-immobilized fiber improved the hemodynamics in all three patients who had developed shock at ..
  98. ncbi [Acute blood purification for septic multiple organ failure]
    Makoto Kobayashi
    Hyogo Emergency Medical Center
    Nihon Rinsho 62:2308-12. 2004
    ..Direct hemoperfusion with polymyxin B immobilized fiber (PMX-DHP) can rapidly improve circulation and decrease blood levels of ..
  99. ncbi Effects of hemoperfusion on serum cardiac troponin T concentrations using polymyxin B-immobilized fibers in septic patients undergoing hemodialysis
    Tsukasa Nakamura
    Department of Medicine, Misato Junshin Hospital, Saitama, Japan
    ASAIO J 48:41-4. 2002
    ..PMX-F is effective in reducing myocardial damage, in part, due to reducing plasma endotoxin levels...
  100. ncbi Polymyxin B-immobilized fiber hemoperfusion with low priming volume in an elderly septic shock patient with marked endotoxemia
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    ASAIO J 51:482-4. 2005
    ..However, her plasma endotoxin level remained high for 3 days. We performed direct hemoperfusion twice using a polymyxin B-immobilized fiber (PMX-F) column with a low priming volume...
  101. ncbi Polymyxin B-immobilized fiber hemoperfusion in a patient with active ulcerative colitis
    Tsukasa Nakamura
    Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan
    ASAIO J 51:471-3. 2005
    ..0 pg/ml; normal < 9.8 pg/ml). She underwent polymyxin B-immobilized fiber (PMX-F) hemoperfusion therapy twice...

Research Grants40

  1. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  2. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  3. POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHY
    JEAN FRECHET; Fiscal Year: 1993
    ..to the determination of trace amounts of materials such as N-acetylneuraminic acid (for cancer diagnosis) or hemoperfusion. This study will also provide a fundamental understanding of the requirements for optimal porous particulate ..
  4. DESIGN OF MATERIAL FOR REMOVAL OF BLOOD TOXIC AGENTS
    DENNIS MC CARTHY; Fiscal Year: 1990
    ..Although there have been some dramatic successes, sorbent hemoperfusion suffers from a marked lack of specificity and relatively poor hemocompatibility...
  5. PHENCYCLIDINE DISPOSITION KINETICS
    Michael Mayersohn; Fiscal Year: 1980
    ..of urine, gastrointestinal and blood pH; diuresis; oral ingestion of specific adsorbents; hemodialysis and hemoperfusion. The disposition of PCP will be quantitated as a function of: dose; acute vs...
  6. MEMBRANE-MEDIATED SORPTIVE HEMOPERFUSION
    Edward Davis; Fiscal Year: 2000
    b>Hemoperfusion is used to treat some patients with life-threatening blood levels of drugs or other toxic compounds...
  7. MEMBRANE-MEDIATED SORPTIVE HEMOPERFUSION
    DANIEL RUDOLPH; Fiscal Year: 1999
    b>Hemoperfusion is used to treat some patients with life-threatening blood levels of drugs or other toxic compounds...
  8. A MINIATURIZED CARBON-FIBER HEMOPERFUSION DEVICE
    DONALD COWSAR; Fiscal Year: 1980
    We are developing and evaluating small blood-compatible activated-carbon hemoperfusion devices...
  9. EX VIVO IMMUNOALTERATION OF PANCREAS ORGAN TRANSPLANTS
    JAMES THISTLETHWAITE; Fiscal Year: 1990
    ..Intact rat pancreases will be placed in an ex vivo normothermic, oxygenated hemoperfusion circuit and monoclonal reagents reactive with passenger leukocytes introduced into the blood perfusate...
  10. MethLock vs. heparin as dialysis catheter lock
    Stephen Ash; Fiscal Year: 2007
    ..In Phase II we will implement the protocol in a number of dialysis centers and complete the study as originally proposed or as modified after Phase I. ..
  11. MethLock vs. heparin as dialysis catheter lock
    Stephen Ash; Fiscal Year: 2008
    ..In Phase II we will implement the protocol in a number of dialysis centers and complete the study as originally proposed or as modified after Phase I. ..
  12. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..The safety systems of the existing PF system will be modified to meet the needs of the stand-alone system. Finally, an animal model of sepsis will be used to check efficacy and safety of the entire system. ..
  13. Nephrogenic Systemic Fibrosis (NSF): A Rodent Model for Therapeutic Intervention
    Wassana Yantasee; Fiscal Year: 2010
    ....
  14. XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2008
    ..Demonstration of efficacy in a pre-clinical model of FHF, as proposed in this application, will provide a basis for future clinical trials of the spheroid reservoir BAL. [unreadable] [unreadable] [unreadable]..
  15. XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2007
    ..Demonstration of efficacy in a pre-clinical model of FHF, as proposed in this application, will provide a basis for future clinical trials of the spheroid reservoir BAL. [unreadable] [unreadable] [unreadable]..
  16. XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2009
    ..Demonstration of efficacy in a pre-clinical model of FHF, as proposed in this application, will provide a basis for future clinical trials of the spheroid reservoir BAL. ..
  17. XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2006
    ..Demonstration of efficacy in a pre-clinical model of FHF, as proposed in this application, will provide a basis for future clinical trials of the spheroid reservoir BAL. [unreadable] [unreadable] [unreadable]..
  18. IMMUNOGENICITY OF A XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2001
    ..A better understanding of the immune response in recipients will improve BAL therapy. ..
  19. IMMUNOGENICITY OF A XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2002
    ..A better understanding of the immune response in recipients will improve BAL therapy. ..
  20. IMMUNOGENICITY OF A XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2000
    ..A better understanding of the immune response in recipients will improve BAL therapy. ..
  21. IMMUNOGENICITY OF A XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 2003
    ..A better understanding of the immune response in recipients will improve BAL therapy. ..
  22. IMMUNOGENICITY OF A XENOGENEIC BIOARTIFICAL LIVER
    Scott Nyberg; Fiscal Year: 1999
    ..A better understanding of the immune response in recipients will improve BAL therapy. ..
  23. XENOGENEIC BIOARTIFICAL LIVER
    Scott L Nyberg; Fiscal Year: 2010
    ..Demonstration of efficacy in a pre-clinical model of FHF, as proposed in this application, will provide a basis for future clinical trials of the spheroid reservoir BAL. ..
  24. Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS
    John A Kellum; Fiscal Year: 2010
    ....
  25. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  26. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2009
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  27. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2006
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  28. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2008
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  29. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2008
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  30. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2007
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  31. A Hemoadsorptive Device for the Treatment of SIRS
    James Winchester; Fiscal Year: 2004
    The overall objective of the proposed project is to develop a hemoperfusion device for the clinical treatment of sepsis and other conditions related to the Systemic Inflammatory Response Syndrome (SIRS). RenalTech International and Dr...
  32. Pediatric Transplant Infections and Outcomes
    Vikas Dharnidharka; Fiscal Year: 2006
    ..abstract_text> ..
  33. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2006
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  34. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2005
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..