salvage therapy

Summary

Summary: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

Top Publications

  1. ncbi Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte
    P Feugier
    Hematology Department, Centre Hospitalier Universitaire de Brabois, 54500 Vandoeuvre les Nancy, France
    J Clin Oncol 23:4117-26. 2005
  2. pmc Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy
    Andrew J Stephenson
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 0001, USA
    J Clin Oncol 25:2035-41. 2007
  3. ncbi A phase II study of docetaxel as salvage chemotherapy in advanced gastric cancer after failure of fluoropyrimidine and platinum combination chemotherapy
    Jae Lyun Lee
    Division of Oncology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul, 138 736, South Korea
    Cancer Chemother Pharmacol 61:631-7. 2008
  4. doi Surgical treatment of hepatocellular carcinoma beyond Milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation
    Marcelo E Facciuto
    Liver Transplant and Hepatobiliary Service, Westchester Medical Center, New York Medical College, 95 Grasslands Road, Valhalla, New York 10595, USA
    Ann Surg Oncol 15:1383-91. 2008
  5. doi Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death
    Toni K Choueiri
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 116:1887-92. 2010
  6. doi Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
    Leonardo Magro
    Service des Maladies du Sang, Centre Hospitalier Regional Universitaire de Lille, Lille Cedex, France
    Blood 114:719-22. 2009
  7. pmc Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
  8. doi Repeated surgery for glioblastoma multiforme: only in combination with other salvage therapy
    Ellen S Mandl
    Department of Neurosurgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Surg Neurol 69:506-9; discussion 509. 2008
  9. doi Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases
    Marco Losa
    Pituitary Unit, Department of Neurosurgery, Istituto Scientifico San Raffaele, Universita Vita Salute, Via Olgettina 60, 20132 Milano, Italy
    Eur J Endocrinol 163:843-51. 2010
  10. doi Long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma
    T Yano
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Endoscopy 43:657-63. 2011

Research Grants

Detail Information

Publications277 found, 100 shown here

  1. ncbi Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte
    P Feugier
    Hematology Department, Centre Hospitalier Universitaire de Brabois, 54500 Vandoeuvre les Nancy, France
    J Clin Oncol 23:4117-26. 2005
    ....
  2. pmc Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy
    Andrew J Stephenson
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 0001, USA
    J Clin Oncol 25:2035-41. 2007
    ..We developed a nomogram to predict the probability of cancer control at 6 years after SRT for PSA-defined recurrence...
  3. ncbi A phase II study of docetaxel as salvage chemotherapy in advanced gastric cancer after failure of fluoropyrimidine and platinum combination chemotherapy
    Jae Lyun Lee
    Division of Oncology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul, 138 736, South Korea
    Cancer Chemother Pharmacol 61:631-7. 2008
    ..Docetaxel has shown promising activity against this disease. In this study, we explored the efficacy and safety of docetaxel monotherapy as salvage chemotherapy in AGC after F and P combination chemotherapy failed...
  4. doi Surgical treatment of hepatocellular carcinoma beyond Milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation
    Marcelo E Facciuto
    Liver Transplant and Hepatobiliary Service, Westchester Medical Center, New York Medical College, 95 Grasslands Road, Valhalla, New York 10595, USA
    Ann Surg Oncol 15:1383-91. 2008
    ..There is no clear consensus regarding the best treatment strategy for patients with advanced hepatocellular carcinoma (HCC)...
  5. doi Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death
    Toni K Choueiri
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 116:1887-92. 2010
    ..BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk
  6. doi Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
    Leonardo Magro
    Service des Maladies du Sang, Centre Hospitalier Regional Universitaire de Lille, Lille Cedex, France
    Blood 114:719-22. 2009
    ..Despite its limited size, this cohort suggests some beneficial activity of imatinib in sclerotic chronic graft-versus-host disease, warranting further prospective investigations...
  7. pmc Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
    ....
  8. doi Repeated surgery for glioblastoma multiforme: only in combination with other salvage therapy
    Ellen S Mandl
    Department of Neurosurgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Surg Neurol 69:506-9; discussion 509. 2008
    ..The purpose of the study was to evaluate the effects, frequency, and complications of repeated surgical resection for GBM relapse...
  9. doi Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases
    Marco Losa
    Pituitary Unit, Department of Neurosurgery, Istituto Scientifico San Raffaele, Universita Vita Salute, Via Olgettina 60, 20132 Milano, Italy
    Eur J Endocrinol 163:843-51. 2010
    ..We assessed the efficacy of treatment with temozolomide, an oral second-generation alkylating agent, in a consecutive series of six patients with aggressive pituitary adenomas...
  10. doi Long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma
    T Yano
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Endoscopy 43:657-63. 2011
    ..The aim of this study was to clarify the long-term results of salvage photodynamic therapy (PDT) for local failure...
  11. doi Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation
    Susumu Eguchi
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Gastroenterol 44:624-9. 2009
    ..The exact efficacy of pre-liver transplant (LT) therapy for hepatocellular carcinoma (HCC) and the impact on survival after LT remain controversial in regard to salvage LT...
  12. pmc Lenalidomide in combination with dexamethasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma
    Edward A Stadtmauer
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Haematol 82:426-32. 2009
    ..Therefore, lenalidomide plus dexamethasone is both effective and tolerable for second-line MM therapy and the data suggest that the greatest benefit occurs with earlier use...
  13. doi Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia
    Xavier C Badoux
    Departments of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:2085-93. 2011
    ..CFAR compared with a similar population who had received fludarabine, cyclophosphamide, and rituximab as salvage therapy, there was no significant improvement in progression-free survival and overall survival appeared worse...
  14. ncbi Recurrent meningioma: salvage therapy with long-acting somatostatin analogue
    Marc C Chamberlain
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL, USA
    Neurology 69:969-73. 2007
    ..The addition of somatostatin inhibits meningioma growth in vitro in some studies. There have been anecdotal reports of octreotide inhibiting growth in meningiomas...
  15. ncbi Upfront high-dose sequential therapy (HDS) versus VACOP-B with or without HDS in aggressive non-Hodgkin's lymphoma: long-term results by the NHLCSG
    A Olivieri
    Department of Hematology, University of Ancona, Italy
    Ann Oncol 16:1941-8. 2005
    ..We designed this study to evaluate the usefulness of HDS followed by high-dose therapy (HDT) with autologous stem cell transplantation as front-line treatment in different subsets of aggressive NHL...
  16. doi Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases
    Arjun Sahgal
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 74:723-31. 2009
    ..To provide actuarial outcomes and dosimetric data for spinal/paraspinal metastases, with and without prior radiation, treated with stereotactic body radiotherapy (SBRT)...
  17. ncbi Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    JAMA 291:1325-32. 2004
    ..Salvage radiotherapy may potentially cure patients with disease recurrence after radical prostatectomy, but previous evidence has suggested that it is ineffective in patients at the highest risk of metastatic disease progression...
  18. ncbi Salvage radiotherapy for isolated prostate specific antigen increase after radical prostatectomy: evaluation of prognostic factors and creation of a prognostic scoring system
    Steven J Buskirk
    Department of Radiation Oncology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Urol 176:985-90. 2006
    ..This study was performed to evaluate the results and prognostic factors associated with radiotherapy for a detectable serum prostate specific antigen level after radical prostatectomy...
  19. ncbi Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer
    K S Clifford Chao
    Department of Radiation Oncology, Washington University Medical School, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 55:312-21. 2003
    ..To analyze the patterns of locoregional failure in patients with head-and-neck cancer treated with inverse planning intensity-modulated radiotherapy (IMRT)...
  20. doi Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer
    Kwang Won Roh
    Department of Radiation Oncology, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 74:1348-55. 2009
    ..We report early preliminary experience with CyberKnife radiosurgery (RS) as salvage treatment for locally recurrent head and neck cancer (HNC)...
  21. ncbi Antiviral activity of lamivudine in salvage therapy for multidrug-resistant HIV-1 infection
    Thomas B Campbell
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Clin Infect Dis 41:236-42. 2005
    ..Available data suggest that lamivudine contributes to partial viral suppression, despite the presence of M184V mutations and high-level phenotypic lamivudine resistance...
  22. ncbi Indium-111-capromab pendetide radioimmunoscintigraphy and prognosis for durable biochemical response to salvage radiation therapy in men after failed prostatectomy
    Cherry T Thomas
    Division of Radiation Oncology, University of Cincinnati, OH, USA
    J Clin Oncol 21:1715-21. 2003
    ..We evaluated the prognostic significance of indium-111 (111In)-capromab pendetide imaging for patients with prostate cancer who underwent salvage radiotherapy (RT) for recurrent disease after prostatectomy...
  23. doi A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma
    Patrick B Johnston
    Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Hematol 85:320-4. 2010
    ..Four patients experienced a Grade 3 or higher pulmonary toxicity. Everolimus has single-agent activity in relapsed/refractory HL and provides proof-of-concept that targeting the mTOR pathway in HL is clinically relevant...
  24. doi Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population
    Giovanna Lucchini
    Clinica Pediatrica, Universita Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, Monza, MI, Italy
    Biol Blood Marrow Transplant 16:1293-301. 2010
    ..Two patients developed chronic limited GVHD. This study underlines the safety of PL-expanded MSC use in children. MSC efficacy seems to be greater in aGVHD than in cGVHD, even after failure of multiple lines of immunosuppression...
  25. pmc Rituximab for steroid-refractory chronic graft-versus-host disease
    Corey Cutler
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 108:756-62. 2006
    ..We conclude that specific anti-B-cell therapy with rituximab may be beneficial for patients with steroidrefractory chronic GVHD. This trial was registered at www.clinicaltrials.gov as #NCT00136396...
  26. ncbi Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results
    Claus Rodel
    Department of Radiation Oncology, Institute of Pathology, University of Erlangen, Germany
    J Clin Oncol 20:3061-71. 2002
    ..To evaluate our long-term experience with combined modality treatment and selective bladder preservation and to identify factors that may predict treatment response, risk of relapse, and survival...
  27. ncbi Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer
    L A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor 48109 0010, USA
    Int J Radiat Oncol Biol Phys 46:1117-26. 2000
    ..To analyze the patterns of local-regional recurrence in patients with head and neck cancer treated with parotid-sparing conformal and segmental intensity-modulated radiotherapy (IMRT)...
  28. ncbi Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis
    P E Majno
    Transplantation Unit, Department of Surgery, University Hospital, Geneva, Switzerland
    Hepatology 31:899-906. 2000
    ....
  29. doi Docetaxel monotherapy as a second-line treatment after failure of fluoropyrimidine and platinum in advanced gastric cancer: experience of 154 patients with prognostic factor analysis
    Jae Cheol Jo
    Division of Oncology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap 2dong, Songpa Gu, Seoul 138 736, South Korea
    Jpn J Clin Oncol 37:936-41. 2007
    ..To investigate the efficacy and safety of docetaxel monotherapy as salvage chemotherapy for advanced gastric cancer (AGC) in clinical practice and to determine the prognostic factors in these patients...
  30. ncbi Salvage surgery following downstaging of unresectable hepatocellular carcinoma--a strategy to increase resectability
    Wan Yee Lau
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR, China
    Ann Surg Oncol 14:3301-9. 2007
    ..However, the resectability of HCC at the time of diagnosis is low (10-30%). This article reviews the use of salvage surgery following tumor downstaging to treat unresectable HCC...
  31. pmc Impact of pre-transplant rituximab on survival after autologous hematopoietic stem cell transplantation for diffuse large B cell lymphoma
    Timothy S Fenske
    Division of Neoplastic Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Blood Marrow Transplant 15:1455-64. 2009
    ..to whether rituximab was (n = 176; +R cohort) or was not (n = 818; -R cohort) administered with front-line or salvage therapy before AuHCT. The +R cohort had superior progression-free survival (PFS; 50% vs 38%; P = ...
  32. doi Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107)
    Sergio Amadori
    Department of Haematology, Tor Vergata University Hospital, Roma, Italy Department of Haematology, St George s Hospital, London, UK
    Br J Haematol 156:205-12. 2012
    ..This study assessed the combination of temsirolimus, an mTOR inhibitor, and lower-dose clofarabine as salvage therapy in older patients with AML...
  33. doi Pilot study of irinotecan/oxalipltin (IROX) combination chemotherapy for patients with gemcitabine- and 5-fluorouracil- refractory pancreatic cancer
    Sung Yong Oh
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Invest New Drugs 28:343-9. 2010
    ..We attempted to evaluate the efficacy and safety of a combination of irinotecan and oxaliplatin (IROX) as a salvage treatment for patients with gemcitabine- and 5-FU- refractory pancreatic cancer...
  34. doi Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy)
    Anna Maria Di Giacomo
    Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Strada delle Scotte, 53100, Siena, Italy
    Cancer Immunol Immunother 60:467-77. 2011
    ..To evaluate the feasibility of ipilimumab treatment for metastatic melanoma outside the boundaries of clinical trials, in a setting similar to that of daily practice...
  35. doi Liver transplantation for recurrent hepatocellular carcinoma on cirrhosis after liver resection: University of Bologna experience
    M Del Gaudio
    Liver and Multiorgan Transplantation Unit, S Orsola Malpighi Hospital, University of Bologna Italy, Bologna, Italy
    Am J Transplant 8:1177-85. 2008
    ..73%, p = NS) and disease-free (48% vs. 71%, p = NS) survival rates were obtained for SLT and primary LT for HCC, respectively. LR is a valid treatment for small HCC and in the event of recurrence, SLT is a safe and effective procedure...
  36. ncbi Photodynamic therapy as salvage treatment for local failures after definitive chemoradiotherapy for esophageal cancer
    Tomonori Yano
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa 277 8577, Japan
    Gastrointest Endosc 62:31-6. 2005
    ..Salvage esophagectomy is the only curative intent treatment option; however, it carries higher morbidity and mortality rates than primary esophagectomy. Response to second-line chemotherapy is quite dismal...
  37. doi High-intensity focused ultrasound as salvage therapy for patients with recurrent prostate cancer after external beam radiation, brachytherapy or proton therapy
    Toyoaki Uchida
    Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo, Tokai University, Isehara, Kanagawa, Japan
    BJU Int 107:378-82. 2011
    To investigate the use of high-intensity focused ultrasound (HIFU) as a salvage therapy in patients with recurrence of localized prostate cancer after external beam radiation (EBRT), brachytherapy, or proton therapy.
  38. ncbi Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma
    Tarun Kewalramani
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 103:3684-8. 2004
    ..25). RICE appears to induce very high CR rates in patients with relapsed and refractory DLBCL; however, further studies are necessary to determine whether this treatment regimen will improve outcomes after ASCT...
  39. doi Is there a role for second-line chemotherapy in advanced gastric cancer?
    Robert Wesolowski
    Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Lancet Oncol 10:903-12. 2009
    ..We review the published data concerning the use of chemotherapy in the second-line setting for the treatment of advanced gastric cancer...
  40. doi Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma
    Sebastian Wortmann
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital of Wurzburg, University of Wurzburg, Oberdurrbacher Strasse 6, 97080 Wurzburg, Germany
    Eur J Endocrinol 162:349-56. 2010
    ..However, there is no evidence for any therapy beneficial in patients failing these therapies. Therefore, we evaluated the effects of the anti-VEGF antibody bevacizumab plus capecitabine as salvage therapy in ACC.
  41. doi Salvage liver transplantation for recurrent hepatocellular carcinoma after liver resection: feasibility of the Milan criteria and operative risk
    B W Kim
    Department of Surgery, Ajou University School of Medicine, Suwon, South Korea
    Transplant Proc 40:3558-61. 2008
    ..The operative difficulties of SLT increase the operative risk. The aim of this study was to evaluate the feasibility of the Milan criteria for SLT and its operative complications...
  42. doi Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent head-and-neck tumors
    Mustafa Cengiz
    Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
    Int J Radiat Oncol Biol Phys 81:104-9. 2011
    ..In this study, we present our results of reirradiation of locally recurrent head-and-neck cancer with image-guided, fractionated, frameless stereotactic body radiotherapy technique...
  43. ncbi Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only?
    Christoph Stephan
    Johann Wolfgang Goethe University Hospital, HIV Treatment and Clinical Research Unit, Medical Department II, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Curr HIV Res 7:320-6. 2009
    ..We investigated the virologic and immunologic responses to a mono-class, nucleoside/nucleotide reverse transcriptase inhibitor - combination therapy consisting of tenofovir and zidovudine/lamivudine/abacavir in therapy experienced patients...
  44. doi Multimodal approaches to the treatment of hepatocellular carcinoma
    Giuseppe Cabibbo
    Unit of Gastroenterology and Hepatology, Academic Department of Internal Medicine, University of Palermo, Italy
    Nat Clin Pract Gastroenterol Hepatol 6:159-69. 2009
    ....
  45. ncbi Salvage chemotherapy with paclitaxel, ifosfamide, and nedaplatin in patients with urothelial cancer who had received prior cisplatin-based therapy
    Nobuo Shinohara
    Department of Urology, Hokkaido University Graduate School of Medicine, Kitaku, Sapporo, Japan
    Cancer Chemother Pharmacol 58:402-7. 2006
    ....
  46. doi Harm and benefits of primary liver resection and salvage transplantation for hepatocellular carcinoma
    A Cucchetti
    Liver and Multiorgan Transplant Unit, University of Bologna, Italy
    Am J Transplant 10:619-27. 2010
    ..An increased proportion of HCC candidates and/or an increased median time-to-transplant could lead to a benefit for waiting-list patients that outweighs this harm...
  47. ncbi Capecitabine and doxorubicin combination chemotherapy as salvage therapy in pretreated advanced gastric cancer
    Sang Joon Shin
    Department of Internal Medicine, Cancer Metastasis Research Center, Yonsei Cancer Center, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134, Shinchon dong, Seodaemun Ku, CPO Box 8044, Seoul, 120 752, South Korea
    Cancer Chemother Pharmacol 61:157-65. 2008
    ..The aim of this study was to evaluate the activity and the safety of a combination regimen of capecitabine and doxorubicin as salvage chemotherapy in advanced gastric cancer patients who had undergone one or two prior chemotherapy regimens...
  48. doi Outcomes of multiple salvage chemotherapy for advanced gastric cancer: implications for clinical practice and trial design
    Yong Wha Moon
    Cancer Metastasis Research Center, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, Korea
    Cancer Chemother Pharmacol 66:797-805. 2010
    ..We analyzed the natural history of advanced gastric cancer with sequential salvage chemotherapy following first-line treatment...
  49. doi Salvage prostate cryoablation: initial results from the cryo on-line data registry
    Louis L Pisters
    Department of Urology, M D Anderson Cancer Center, Houston, Texas, USA
    J Urol 180:559-63; discussion 563-4. 2008
    ..We report contemporary outcomes of salvage cryoablation at a large number of centers which have participated in the COLD (Cryo On-Line Data) Registry...
  50. ncbi Comparison of health-related quality of life and prostate-associated symptoms after primary and salvage cryotherapy for prostate cancer
    Aristotelis G Anastasiadis
    Department of Urology, Columbia University Health Sciences, 161 Fort Washington Avenue, Herbert Irving Pavilion, 11th Floor, New York, NY 10032, USA
    J Cancer Res Clin Oncol 129:676-82. 2003
    ....
  51. pmc Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors
    Brian J Scott
    Lahey Clinic Medical Center, Department of Neurology, 41 Mall Road, Burlington, MA 01805, USA
    Neuro Oncol 12:603-7. 2010
    ..3 weeks. Grade III/IV toxicities were seen in 13 of 24 patients (54%). Subsequently with bevacizumab salvage therapy, 5 of 24 patients (21%) had a PR, the APF6 was 12.5%, and the median TTP was 8 weeks...
  52. ncbi A randomized controlled trial to evaluate antiretroviral salvage therapy guided by rules-based or phenotype-driven HIV-1 genotypic drug-resistance interpretation with or without concentration-controlled intervention: the Resistance and Dosage Adapted Regi
    Carlo Torti
    Institute for Infectious and Tropical Diseases, Brescia, Italy
    Clin Infect Dis 40:1828-36. 2005
    ..intervention (CCI) and rules-based human immunodeficiency virus (HIV) type 1 genotype drug-resistance interpretation (GI) or virtual phenotype drug-resistance interpretation (VPI) may improve the outcome of HIV salvage therapy.
  53. pmc Patterns of relapse and prognosis after bevacizumab failure in recurrent glioblastoma
    F M Iwamoto
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Neurology 73:1200-6. 2009
    ..However, patterns of relapse, prognosis, and outcome of further therapy after bevacizumab failure have not been studied systematically...
  54. ncbi Irinotecan (CPT-11) and mitomycin-C (MMC) as second-line therapy in advanced gastric cancer: a phase II study of the Gruppo Oncologico dell' Italia Meridionale (prot. 2106)
    Francesco Giuliani
    Department of Medical Oncology, Oncology Institute, Bari, Italy
    Am J Clin Oncol 28:581-5. 2005
    ..The aim of this study was to evaluate the activity and toxicity of a combination regimen of CPT-11 and mitomycin-c as second-line chemotherapy for pretreated patients with advanced, metastatic, or both, gastric adenocarcinoma...
  55. ncbi Free tissue transfer to manage salvage laryngectomy defects after organ preservation failure
    Kirk P Withrow
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 117:781-4. 2007
    ..We hypothesize that even when sufficient mucosa is present to close the defect primarily, introduction of vascularized tissue to close the defect may improve outcomes...
  56. doi Radiographic patterns of relapse in glioblastoma
    Marc C Chamberlain
    Division of Neuro Oncology, Department of Neurology and Neurological Surgery, Fred Hutchinson Research Cancer Center, University of Washington, 895 Eastlake Ave, POB Box 19023, MS G4 940, Seattle, WA 98109 1023, USA
    J Neurooncol 101:319-23. 2011
    Glioblastoma (GBM) pathologically is defined as an infiltrative glioma and salvage therapy with bevacizumab is believed to increase the incidence of diffuse and distant invasion as assessed radiographically...
  57. ncbi Weekly irinotecan in patients with metastatic gastric cancer failing cisplatin-based chemotherapy
    Jong Ho Chun
    Gastric Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea
    Jpn J Clin Oncol 34:8-13. 2004
    ..The goal of this study is to determine the efficacy and toxicity of weekly irinotecan as second-line chemotherapy in advanced gastric cancer after failure of cisplatin-based regimen...
  58. doi Trastuzumab and gemcitabine as salvage therapy in heavily pre-treated patients with metastatic breast cancer
    Rupert Bartsch
    First Department of Medicine and Cancer Centre, Clinical Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Cancer Chemother Pharmacol 62:903-10. 2008
    ..In this trial, we evaluated the efficacy and safety of gemcitabine and trastuzumab after earlier exposure to anthracyclines, docetaxel and/or vinorelbine, and trastuzumab...
  59. ncbi Nonmyeloablative allogeneic hematopoietic transplantation: a promising salvage therapy for patients with non-Hodgkin's lymphoma whose disease has failed a prior autologous transplantation
    Maricer P Escalon
    Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 22:2419-23. 2004
    ..We investigated the safety and efficacy of nonmyeloablative stem-cell transplantation in these patients...
  60. ncbi Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma
    Shin Hwang
    Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Liver Transpl 13:741-6. 2007
    ..These results indicate that every combination of prior hepatectomy and living donor liver graft is feasible for patients undergoing salvage LDLT, and the acceptable extent of HCC for salvage LDLT is equivalent to that for primary LDLT...
  61. doi R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. A GEL/TAMO study
    Alejandro Martin
    Department of Hematology, Complejo Hospitalario de Zamora, Avenida de Requejo 35, Zamora 49022, Spain
    Haematologica 93:1829-36. 2008
    ....
  62. ncbi Prostate cancer DNA ploidy and response to salvage hormone therapy after radiotherapy with or without short-term total androgen blockade: an analysis of RTOG 8610
    A Pollack
    Department of Radiation Oncology, Fox Chase Cancer Center, and Radiation Therapy Oncology Group, Philadelphia, PA 19111, USA
    J Clin Oncol 21:1238-48. 2003
    ..The protocol treatment randomization was RT alone versus RT plus short-course (approximately 4 months) neoadjuvant and concurrent total androgen blockade (RT+TAB)...
  63. doi Salvage therapy with single agent bevacizumab for recurrent glioblastoma
    Marc C Chamberlain
    Department of Neurology and Neurosurgery, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1023, USA
    J Neurooncol 96:259-69. 2010
    ..5 months). 6-month and 12-month PFS were 42% and 22% respectively. Single agent bevacizumab demonstrated efficacy and acceptable toxicity in this cohort of adults with recurrent alkylator-refractory GBM...
  64. ncbi Treatment of multiple myeloma
    Bart Barlogie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 103:20-32. 2004
    ..Fundamental and clinical research should, therefore, focus on the molecular and biologic mechanisms of treatment failure in the high-risk subgroup...
  65. ncbi Radiotherapy after prostatectomy: improved biochemical relapse-free survival with whole pelvic compared with prostate bed only for high-risk patients
    Michael T Spiotto
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 69:54-61. 2007
    ..To compare the biochemical relapse-free survival (bRFS) among patients receiving whole pelvic radiotherapy (WPRT) vs. prostate bed RT (PBRT) after radical prostatectomy...
  66. pmc Comparison of single versus fractionated dose of stereotactic radiotherapy for salvaging local failures of nasopharyngeal carcinoma: a matched-cohort analysis
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
    Head Neck Oncol 1:13. 2009
    ..Stereotactic radiation using single or multiple fractions have been employed in re-irradiation of NPC, but the optimal fractionation scheme and dose are not clear...
  67. ncbi Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 110:1417-28. 2007
    ....
  68. ncbi Rituximab, gemcitabine and oxaliplatin: an effective salvage regimen for patients with relapsed or refractory B-cell lymphoma not candidates for high-dose therapy
    T El Gnaoui
    Department of Clinical Hematology, Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Paris XII University, Creteil, France
    Ann Oncol 18:1363-8. 2007
    ..Rituximab, gemcitabine and oxaliplatin are active as single agents in relapsed or refractory lymphoma, and have demonstrated synergistic effects in vitro and in vivo...
  69. doi Salvage surgery after induction chemotherapy with paclitaxel/cisplatin and primary radiotherapy for advanced laryngeal and hypopharyngeal carcinomas
    A Relic
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankheiten, plastische und ästhetische Operationen der Universität Würzburg, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Eur Arch Otorhinolaryngol 266:1799-805. 2009
    ..In the light of our results, unfavourable outcome after salvage surgery must be pointed out when initially informing patients about different therapeutic options for advanced LHC...
  70. doi The pectoralis major myocutaneous flap revisited: a reliable technique for head and neck reconstruction
    J Nicholas McLean
    Emory Division of Plastic and Reconstructive Surgery, Atlanta, GA 30308, USA
    Ann Plast Surg 64:570-3. 2010
    ..Patients who had radiation therapy had significantly higher complication rates. The PMMF flap remains a very versatile technique with proven reliability for soft tissue coverage of many head and neck defects...
  71. pmc The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy
    Jean Claude M Rwigema
    Departments of Radiation Oncology, University of Pittsburgh Cancer Institute, PA, USA
    Am J Clin Oncol 34:372-9. 2011
    ..To assess the effect of stereotactic body radiotherapy (SBRT) dose and tumor volume on outcomes in patients with recurrent, previously irradiated squamous cell carcinoma of the head and neck...
  72. ncbi Reduced intensity conditioning and allogeneic stem cell transplantation after salvage therapy integrating alemtuzumab for patients with relapsed peripheral T-cell non-Hodgkin's lymphoma
    G G Wulf
    Bone Marrow Transplant 36:271-3. 2005
  73. ncbi Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung
    Harubumi Kato
    Department of Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 42:103-11. 2003
    ..PDT using the second generation photosensitizer NPe6 and a diode laser will likely become a standard modality of PDT for central type early superficial squamous cell carcinoma of the lung...
  74. ncbi Feasibility of salvage liver transplantation for patients with recurrent hepatocellular carcinoma
    Rey Heng Hu
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Clin Transplant 19:175-80. 2005
    ..Salvage liver transplantation is an alternative treatment for recurrent HCC. The transplantability for patients with recurrent HCC has not been well studied...
  75. ncbi High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: an indication for salvage liver transplantation
    Margarita Sala
    Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Catalonia, Spain
    Liver Transpl 10:1294-300. 2004
    ..In conclusion, this policy is clinically effective and could further improve the outcome of resected patients...
  76. pmc Phase II study of erlotinib as a salvage treatment for non-small-cell lung cancer patients after failure of gefitinib treatment
    D H Lee
    Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Songpa Gu, Seoul, South Korea
    Ann Oncol 19:2039-42. 2008
    ..We conducted a phase II study of erlotinib after failure of gefitinib treatment in patients with non-small-cell lung cancer (NSCLC)...
  77. ncbi Salvage therapy for prostate cancer recurrence after radiation therapy
    Jared M Cox
    Division of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Urol Rep 10:199-205. 2009
    ..As these modalities continue to improve and patient selection is optimized, better results will evolve...
  78. doi The assessment of pharyngocutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypopharynx
    Richard Dirven
    Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Australia
    Laryngoscope 119:1691-5. 2009
    ....
  79. doi Salvage therapy for Hodgkin's lymphoma
    Fahd Quddus
    Section of Hematology and Oncology, UNMC Oncology Hematology Section, 987680 Nebraska Medical Center, University of Nebraska, Omaha, NE, USA
    Cancer J 15:161-3. 2009
    ..This article provides a review of the current literature regarding salvage therapy for HL.
  80. doi Pectoralis myofascial flap during salvage laryngectomy prevents pharyngocutaneous fistula
    Urjeet A Patel
    Department of Otolaryngology Head and Neck Surgery, Northwestern University, and Division of Otolaryngology Head and Neck Surgery, Cook County Hospital, Chicago, IL 60611, USA
    Otolaryngol Head Neck Surg 141:190-5. 2009
    ..To determine the rate of pharyngocutaneous fistula after salvage laryngectomy and assess if pectoralis myofascial flap reinforcement over primary pharyngeal closure prevents pharyngocutaneous fistula...
  81. doi Salvage therapy for acute myeloid leukemia with fludarabine, cytarabine, and idarubicin with or without gemtuzumab ozogamicin and with concurrent or sequential G-CSF
    Mike G Martin
    Section of Leukemia and Bone Marrow Transplantation, Division of Oncology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Am J Hematol 84:733-7. 2009
    ..The patients who received G-CSF concurrently with chemotherapy had improved outcomes. Am. J. Hematol., 2009. (c) 2009 Wiley-Liss, Inc...
  82. ncbi ACNU-cisplatin continuous infusion chemotherapy as salvage therapy for recurrent glioblastomas: phase II study
    Ho Shin Gwak
    Department of Neurosurgery, Korea Institute of Radiological and Medical Science, 139 706, 215 4 Gongreung dong, Nowon Gu, Seoul, Korea
    J Neurooncol 75:173-80. 2005
    ....
  83. ncbi John E. Bennett Forum on Deep Mycoses Study Design 2004: Candidiasis and salvage therapy for aspergillosis
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Clin Infect Dis 41:S369-70. 2005
  84. doi Salvage therapy with bicalutamide 150 mg in nonmetastatic castration-resistant prostate cancer
    Michele Lodde
    Department of Urology, Centre Hospitalier Universitaire du Québec, Quebec, Canada
    Urology 76:1189-93. 2010
    ..To evaluate the rate and duration of prostate-specific antigen (PSA) response to high-dose bicalutamide (150 mg) in nonmetastatic castration-resistant prostate cancer patients and its impact on metastasis-free survival...
  85. doi Lenalidomide is effective as salvage therapy in refractory or relapsed multiple myeloma: analysis of the Spanish Compassionate Use Registry in advanced patients
    Adrian Alegre
    Department of Hematology, Hospital Universitario de la Princesa, C Diego de Leon, 62, 28006 Madrid, Spain
    Int J Hematol 93:351-60. 2011
    We evaluated the clinical results of lenalidomide (Len) as a compassionate salvage therapy in refractory/relapsed multiple myeloma (MM) patients...
  86. doi A pretreatment nomogram predicting biochemical failure after salvage cryotherapy for locally recurrent prostate cancer
    Philippe E Spiess
    Department of Urology, Columbia University, New York, NY, USA
    BJU Int 106:194-8. 2010
    ....
  87. ncbi Colistin as a salvage therapy for nosocomial infections caused by multidrug-resistant bacteria in the ICU
    Hatem Kallel
    Service de Reanimation Medicale, CHU Habib Bourguiba, Route el Ain Km 1, 3029 Sfax, Tunisia
    Int J Antimicrob Agents 28:366-9. 2006
    ..9%). Renal failure occurred in only seven cases. We conclude that colistin can be a safe and effective salvage therapeutic option for nosocomial infections caused by multidrug-resistant A. baumannii or P. aeruginosa...
  88. ncbi Predictive factors of tumor control and survival after radiosurgery for local failures of nasopharyngeal carcinoma
    Daniel T T Chua
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 66:1415-21. 2006
    ..To identify patients that would benefit from radiosurgery, we reviewed our data with emphasis on factors that predicted treatment outcome...
  89. ncbi Quality of life 2 years after salvage cryosurgery for the treatment of local recurrence of prostate cancer after radiotherapy
    John W Robinson
    Department of Oncology and Program in Clinical Psychology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada
    Urol Oncol 24:472-86. 2006
    ..The present study's purpose was to further the understanding of the quality of life outcomes of salvage cryosurgery...
  90. doi Raltegravir, maraviroc, etravirine: an effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience
    Silvia Nozza
    Department of Infectious Diseases, San Raffaele Scientific Institute, Italy
    AIDS 24:924-8. 2010
    ..Although long-term safety needs further study, this protease inhibitor and nucleoside analogue-sparing regimen showed sustained efficacy...
  91. doi Rituximab as salvage therapy for refractory chronic GVHD
    M Mohty
    Bone Marrow Transplant 41:909-11. 2008
  92. ncbi Salvage therapy in relapsed squamous cell carcinoma of the oral cavity: how and when?
    Chun Ta Liao
    Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Cancer 112:94-103. 2008
    ..In addition, salvage therapy may be a significant source of morbidity in patients with relapsing OSCC...
  93. ncbi A phase II study of irinotecan with bi-weekly, low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFIRI) as salvage therapy for patients with advanced or metastatic gastric cancer
    Seong Geun Kim
    Department of Internal Medicine, Dong A University College of Medicine, 3 1 Dongdaeshin dong, Seo Gu, Busan, 602 715, Korea
    Jpn J Clin Oncol 37:744-9. 2007
    ..and efficacy of a modified FOLFIRI regimen (irinotecan with bi-weekly, low dose leucovorin (ldLV) and bolus and continuous infusion with 5-fluorouracil (5-FU)) as a salvage therapy for patients with advanced or metastatic gastric cancer.
  94. doi Mantle cell lymphoma: Frontline and salvage therapy
    Jorge E Romaguera
    Department of Lymphoma Myeloma, Unit 429, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Hematol Malig Rep 3:204-9. 2008
    ..New insights into resistance pathways and new drugs created to inhibit them offer great promise in the treatment of newly diagnosed and previously treated MCL...
  95. ncbi Salvage cryoablation of the prostate: followup and analysis of predictive factors for outcome
    Chee Kwan Ng
    Division of Urology, Department of Pathology, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    J Urol 178:1253-7; discussion 1257. 2007
    ..We assessed the efficacy of cryoablation of the prostate with an emphasis on finding predictive factors that lead to improved outcome...
  96. doi Partial salvage cryoablation of the prostate for recurrent prostate cancer after radiotherapy failure
    Michael L Eisenberg
    Department of Urology, University of California San Francisco, San Francisco, California 94143 1695, USA
    Urology 72:1315-8. 2008
    ..To determine the efficacy of partial cryoablation of the prostate in the salvage setting...
  97. ncbi Salvage cryotherapy for recurrent prostate cancer after radiation failure: a prospective case series of the first 100 patients
    Mohamed Ismail
    The Royal Surrey County Hospital and St Luke s Cancer Centre, Guildford, Surrey, UK
    BJU Int 100:760-4. 2007
    ..To report the short- to intermediate-term experience of using salvage targeted cryoablation of the prostate (TCAP) for the recurrence of localized prostate cancer after radiotherapy...
  98. ncbi Review of primary and salvage cryoablation for prostate cancer
    Joseph L Chin
    Division of Urological Surgery, University of Western Ontario, London, Canada N6A 4G5
    Cancer Control 14:231-7. 2007
    ..Herein we present a review and summary reports on primary cryoablation for prostate cancer and salvage cryoablation following radiation failure...
  99. doi Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study
    Kaoru Kubota
    National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 3:1439-45. 2008
    ..Available tumor biopsy samples were analyzed to examine relationships between biomarkers and clinical outcome...
  100. doi Salvage therapy with bevacizumab-sunitinib combination after failure of sunitinib alone for metastatic renal cell carcinoma: a case series
    Jacques Medioni
    Department of Oncology, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
    Eur Urol 56:207-11; quiz 211. 2009
    ..metastatic renal cell carcinoma treated with bevacizumab (10 mg/kg) in combination with sunitinib 25-50 mg as salvage therapy after disease progression under sunitinib monotherapy...
  101. ncbi Pharyngocutaneous fistula repair after radiotherapy and salvage total laryngectomy
    Lawrence Iteld
    Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Reconstr Microsurg 23:339-45. 2007
    ..Early repair is strongly recommended once a postlaryngectomy pharyngocutaneous fistula is identified...

Research Grants75

  1. A Resorbable Cryoprobe Provides a Salvage Therapeutic Option
    KRISTI SNYDER; Fiscal Year: 2007
    ..applied in specific locations of the diseased area; (3) The application of will initially be intended as a salvage therapy tool for treating prostate cancer and; (4) the utilization of this device may also be an effective nerve-..
  2. ENHANCING ACTIVITY OF ALKYLATING AGENTS IN NEUROBLASTOMA
    CHARLES PATRICK REYNOLDS; Fiscal Year: 2010
    ..the frequency of p53 loss-of-function (p53 LOF) in recurrent neuroblastoma and to determine if response to salvage therapy correlates with p53 status...
  3. SPORE in Lymphoma
    Richard Ambinder; Fiscal Year: 2007
    ..with high dose therapy and autologous peripheral stem cell rescue insofar as this has emerged as the standard salvage therapy for HL patients and reduces tumor bulk and tumor-associated cytokines, chemokines and other molecules that ..
  4. SYNTHESIS AND BIOTRANSFORMATION OF ANTI-HIV PRODRUGS
    CHUNG CHU; Fiscal Year: 2007
    ..it has demonstrated a favorable viral resistant profile in vitro as well as in vivo, which is necessary for salvage therapy for AIDS patients. Therefore, DAPD has been designated as a "fast-track" compound by the FDA...
  5. Induction of molecular Mediators by Enteral Nutrients in the Postischemic Gut
    Rosemary Kozar; Fiscal Year: 2007
    ..consequences of admin- istration of arginine and glutamine in combination when delivered as synchronous and salvage therapy to the postischemic gut...
  6. Induction of molecular Mediators by Enteral Nutrients in the Postischemic Gut
    Rosemary A Kozar; Fiscal Year: 2010
    ..consequences of admin- istration of arginine and glutamine in combination when delivered as synchronous and salvage therapy to the postischemic gut...
  7. INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TEST
    Edward Acosta; Fiscal Year: 2006
    ..viral phenotypic drug susceptibility (IC50) information to assist clinicians in choosing optimal regimens for salvage therapy of their treatment-experienced HIV-infected patients...
  8. Improved Diagnosis in ALL
    Dietrich Stephan; Fiscal Year: 2002
    ..b>Salvage therapy for this poor outcome group is currently ineffectual (LTDFS in less than 10 percent of cases) but there is ..
  9. ACTIVITY OF RESISTANT VARIANTS OF HIV PROTEASE
    Irene Weber; Fiscal Year: 2009
    ..of mutant proteases, resulting in high potency, excellent resistance profile, and approval for AIDS salvage therapy in June 2006...
  10. ACTIVITY OF RESISTANT VARIANTS OF HIV PROTEASE
    Irene T Weber; Fiscal Year: 2011
    ..of mutant proteases, resulting in high potency, excellent resistance profile, and approval for AIDS salvage therapy in June 2006...
  11. ACTIVITY OF RESISTANT VARIANTS OF HIV PROTEASE
    Irene T Weber; Fiscal Year: 2010
    ..of mutant proteases, resulting in high potency, excellent resistance profile, and approval for AIDS salvage therapy in June 2006...
  12. Hu1D10 in CLL: CLINICAL AND LABORATORY STUDIES
    John Byrd; Fiscal Year: 2006
    ..CLL); Rituximab has moved into frontline CLL drug combinations, and Campath-1H has been approved for salvage therapy. Our group has been actively pursuing the pre-clinical and clinical development of a humanized HLA-DR beta-..
  13. Synthesis/Biological evaluation of Anti-HIV Nucleosides
    David Chu; Fiscal Year: 2005
    ..Thus, Patients need additional drugs for salvage therapy. Previously, under the support of this grant we have discovered several clinical candidates for HIV (DAPD; ..
  14. ROLE OF MULTIDRUG RESISTANCE MUTATION IN HIV FITNESS
    Prem Sharma; Fiscal Year: 2002
    ..through the proposed studies should help optimize protocols of specific drug combinations for clinical trials, based on drugs which select for viruses that are less fit and design a salvage therapy for multi-drug failure subjects.
  15. TECHNIQUES FOR CALCULATING TUMOR DOSIMETRY FROM IMAGING
    KENNETH KORAL; Fiscal Year: 2003
    ..Applications of the methods to other therapies and to imaging with other multi-gamma-emission radionuclides such as 111-In are also possible. ..
  16. Community-based accompaniment with supervised antiretrovirals in Lima, Peru
    Sonya Shin; Fiscal Year: 2009
    ..We will enroll individuals living in extreme poverty who are starting either first-line HAART or salvage therapy due to virologic failure. Those residing in intervention clusters will receive 12 months of DOT-HAART...
  17. Community-based accompaniment with supervised antiretrovirals in Lima, Peru
    Sonya S Shin; Fiscal Year: 2010
    ..We will enroll individuals living in extreme poverty who are starting either first-line HAART or salvage therapy due to virologic failure. Those residing in intervention clusters will receive 12 months of DOT-HAART...
  18. Rapid Diagnosis of XDR Tuberculosis
    David Alland; Fiscal Year: 2010
    ..Early and rapid detection of XDR TB could be crucial to disease management by alerting physicians to use salvage therapy and to institute special infection control procedures...
  19. Focal HIFU Ablation of Prostate Cancer Using Advanced Ultrasound Guidance
    Narendra T Sanghvi; Fiscal Year: 2010
    ..3) developing methods to identify viable cancer regions in radiation-treated patients who require salvage therapy. The proposed RRI-FSI Partnership will include internationally respected clinical collaborators who are ..
  20. Fitness of Enfuvirtide-(T-20)-Resistant HIV-1
    Daniel Kuritzkes; Fiscal Year: 2006
    ..Results of these studies will provide a deeper understanding of the molecular, virologic, and clinical consequences ofT-20 resistance, and may help guide the use of T-20 in salvage therapy.
  21. DEVELOPMENT OF POLY-L-GLUTAMIC ACID PACLITAXEL CONJUGATE
    Sidney Wallace; Fiscal Year: 2005
    ..A phase I clinical trial of CT-2103 as single agent salvage therapy for patients with advanced solid tumors demonstrated safety and tolerability in dose up to 266 mg equivalent ..
  22. Fitness of Enfuvirtide-(T-20)-Resistant HIV-1
    Daniel Kuritzkes; Fiscal Year: 2003
    ..Results of these studies will provide a deeper understanding of the molecular, virologic, and clinical consequences ofT-20 resistance, and may help guide the use of T-20 in salvage therapy.
  23. Molecular Profiling to Predict Response to Chemotherapy
    Johnathan Lancaster; Fiscal Year: 2006
    ..Prospectively collected ovarian samples will be arrayed and the clinical response to primary and salvage therapy observed...