oxygen inhalation therapy

Summary

Summary: Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)

Top Publications

  1. ncbi Benefits of oxygen on exercise performance and pulmonary hemodynamics in patients with COPD with mild hypoxemia
    Keisaku Fujimoto
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Chest 122:457-63. 2002
  2. ncbi Acute exacerbations of chronic obstructive pulmonary disease
    Kenneth H Palm
    Department of Emergency Medicine, Mayo Medical School, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA
    Emerg Med Clin North Am 21:331-52, viii. 2003
  3. ncbi Managing acute respiratory failure during exacerbation of chronic obstructive pulmonary disease
    Greg L Schumaker
    Pulmonary, Critical Care, and Sleep Division, Tufts New England Medical Center, Boston, Massachusetts, USA
    Respir Care 49:766-82. 2004
  4. ncbi Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study
    James I Hagadorn
    Division of Neonatology, Connecticut Children s Medical Center, 282 Washington St, Hartford, CT 06106, USA
    Pediatrics 118:1574-82. 2006
  5. ncbi Randomised trial of ambulatory oxygen in oxygen-dependent COPD
    Y Lacasse
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Eur Respir J 25:1032-8. 2005
  6. ncbi Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy
    S Marti
    Servei de Pneumologia, Hospital General Vall d Hebron, and Laobratori de Bioestadística i Epidemiologia, Universitat Autonoma de Barcelona, Spain
    Eur Respir J 27:689-96. 2006
  7. ncbi Impact of a physiologic definition on bronchopulmonary dysplasia rates
    Michele C Walsh
    Rainbow Babies and Childrens Hospital, Department of Pediatrics, CASE Case Western Reserve University, 11100 Euclid Ave, Mailstop 6010, Cleveland, OH 44106, USA
    Pediatrics 114:1305-11. 2004
  8. pmc Long-term morbidity and mortality following hypoxaemic lower respiratory tract infection in Gambian children
    T E West
    Medical College of Virginia, Richmond, USA
    Bull World Health Organ 77:144-8. 1999
  9. ncbi Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea
    Takuji Toyama
    Gunma Prefectural Cardiovascular Center, Maebashi, Japan
    Circ J 73:299-304. 2009
  10. ncbi Hypoxaemia among children in rural hospitals in Papua New Guinea: epidemiology and resource availability--a study to support a national oxygen programme
    Francis Wandi
    Department of Paediatrics, Kundiawa Hospital, Simbu Province, Papua New Guinea
    Ann Trop Paediatr 26:277-84. 2006

Research Grants

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Neil Finer; Fiscal Year: 2005
  2. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Neil Finer; Fiscal Year: 2007
  3. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
  4. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2003
  5. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh Singhal; Fiscal Year: 2008
  6. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh Singhal; Fiscal Year: 2006
  7. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2001
  8. Rapid Clinical Snapshots from the EMR among Pneumonia Patients
    Gabriel J Escobar; Fiscal Year: 2010
  9. HOW MUCH DOES SHE REALLY DRINK--HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 1999
  10. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Fernando Martinez; Fiscal Year: 2008

Detail Information

Publications219 found, 100 shown here

  1. ncbi Benefits of oxygen on exercise performance and pulmonary hemodynamics in patients with COPD with mild hypoxemia
    Keisaku Fujimoto
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Chest 122:457-63. 2002
    ..To clarify the effects of oxygen on exercise performance and pulmonary hemodynamics during exercise in patients with COPD with mild hypoxemia at rest...
  2. ncbi Acute exacerbations of chronic obstructive pulmonary disease
    Kenneth H Palm
    Department of Emergency Medicine, Mayo Medical School, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA
    Emerg Med Clin North Am 21:331-52, viii. 2003
    ..The focus is on the presentation of acute exacerbations of COPD in the emergency department and the available evidence for testing and treatment...
  3. ncbi Managing acute respiratory failure during exacerbation of chronic obstructive pulmonary disease
    Greg L Schumaker
    Pulmonary, Critical Care, and Sleep Division, Tufts New England Medical Center, Boston, Massachusetts, USA
    Respir Care 49:766-82. 2004
    ..For invasively ventilated patients the clinical emphasis should be on improving patient-ventilator interaction and avoiding dynamic hyperinflation (intrinsic positive end-expiratory pressure)...
  4. ncbi Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study
    James I Hagadorn
    Division of Neonatology, Connecticut Children s Medical Center, 282 Washington St, Hartford, CT 06106, USA
    Pediatrics 118:1574-82. 2006
    ....
  5. ncbi Randomised trial of ambulatory oxygen in oxygen-dependent COPD
    Y Lacasse
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Eur Respir J 25:1032-8. 2005
    ..Ambulatory oxygen had no effect on any of the outcomes. In conclusion, the current results do not support the widespread provision of ambulatory oxygen to patients with oxygen-dependent chronic obstructive pulmonary disease...
  6. ncbi Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy
    S Marti
    Servei de Pneumologia, Hospital General Vall d Hebron, and Laobratori de Bioestadística i Epidemiologia, Universitat Autonoma de Barcelona, Spain
    Eur Respir J 27:689-96. 2006
    ..These factors should be taken into account when considering the management and prognosis of these patients...
  7. ncbi Impact of a physiologic definition on bronchopulmonary dysplasia rates
    Michele C Walsh
    Rainbow Babies and Childrens Hospital, Department of Pediatrics, CASE Case Western Reserve University, 11100 Euclid Ave, Mailstop 6010, Cleveland, OH 44106, USA
    Pediatrics 114:1305-11. 2004
    ..Safety (apnea, bradycardia, increased oxygen use) and outcomes of the physiologic definition versus the clinical definition were assessed...
  8. pmc Long-term morbidity and mortality following hypoxaemic lower respiratory tract infection in Gambian children
    T E West
    Medical College of Virginia, Richmond, USA
    Bull World Health Organ 77:144-8. 1999
    ..Survival depends more on nutritional status than on having been hypoxaemic. Investment in oxygen therapy appears justified, and efforts should be made to improve nutrition in malnourished children with pneumonia...
  9. ncbi Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea
    Takuji Toyama
    Gunma Prefectural Cardiovascular Center, Maebashi, Japan
    Circ J 73:299-304. 2009
    ..Central sleep apnea, often found in patients with chronic heart failure (CHF), has a high risk of poor prognosis...
  10. ncbi Hypoxaemia among children in rural hospitals in Papua New Guinea: epidemiology and resource availability--a study to support a national oxygen programme
    Francis Wandi
    Department of Paediatrics, Kundiawa Hospital, Simbu Province, Papua New Guinea
    Ann Trop Paediatr 26:277-84. 2006
    ..We also established baseline mortality rate data for all children admitted to five hospitals, for children with a diagnosis of pneumonia and for neonates to evaluate a future intervention...
  11. doi Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease
    Maximo Vento
    Department of Pediatrics, Neonatal Research Unit, Division of Neonatology, University Hospital La Fe, Valencia, Spain
    Pediatrics 124:e439-49. 2009
    ..The goal was to reduce adverse pulmonary adverse outcomes, oxidative stress, and inflammation in neonates of 24 to 28 weeks of gestation initially resuscitated with fractions of inspired oxygen of 30% or 90%...
  12. pmc NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Parramatta Road, Camperdown, 2050, Australia
    BMC Pediatr 11:6. 2011
    ..In order to answer this clinical dilemma reliably, large scale trial evidence is needed...
  13. pmc Meeting oxygen needs in Africa: an options analysis from the Gambia
    Stephen R C Howie
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, Gambia
    Bull World Health Organ 87:763-71. 2009
    ..To compare oxygen supply options for health facilities in the Gambia and develop a decision-making algorithm for choosing oxygen delivery systems in Africa and the rest of the developing world...
  14. ncbi Compliance with LTOT and consumption of mobile oxygen
    T Ringbaek
    Department of Internal Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark
    Respir Med 93:333-7. 1999
    ..Using lists referring to the actual usage and discussing the usage with the patients may improve the compliance and cost-benefit...
  15. ncbi Drugs (including oxygen) in severe COPD
    P Albert
    Division of Infection and Immunity, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
    Eur Respir J 31:1114-24. 2008
    ..Ambulatory oxygen improves exercise capacity, but whether it is used appropriately is in doubt. Overall, short burst oxygen therapy does not offer a benefit and therefore cannot be recommended...
  16. ncbi Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    Aneesh B Singhal
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 58:945-52. 2002
    ..Hyperbaric oxygen therapy is considered an important stroke treatment strategy...
  17. ncbi A pilot study of normobaric oxygen therapy in acute ischemic stroke
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 36:797-802. 2005
    ..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke...
  18. ncbi Oxygen for treatment of severe pneumonia in The Gambia, West Africa: a situational analysis
    S E Hill
    Department of Public Health, University of Otago, Wellington, New Zealand
    Int J Tuberc Lung Dis 13:587-93. 2009
    ..Health facilities in The Gambia, West Africa...
  19. ncbi Hypoxaemia in children with severe pneumonia in Papua New Guinea
    T Duke
    Goroka Base Hospital, Eastern Highlands Province, Papua New Guinea
    Int J Tuberc Lung Dis 5:511-9. 2001
    ....
  20. ncbi The potential impact of anaemia of chronic disease in COPD
    T Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and UPRES EA2397 Université Paris VI Pierre et Marie Curie, Paris, France
    Eur Respir J 27:390-6. 2006
    ..When this body of knowledge is available, the question of the putative benefits of raising haemoglobinaemia in chronic obstructive pulmonary disease will have to be addressed...
  21. ncbi Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia
    Shimin Liu
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 26:1274-84. 2006
    ..These results suggest that maintaining penumbral oxygenation by normobaric oxygen treatment during ischemia lead to neuroprotection, which is further reflected by the decreased production of ROS, MMP-9, and caspase-8...
  22. ncbi Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: A prospective, multicenter study
    Philippe Jolliet
    Medical Intensive Care Division, University Hospital, Geneva, Switzerland
    Crit Care Med 31:878-84. 2003
    ....
  23. ncbi N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen
    Scott T Johnson
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Shock 28:484-90. 2007
    ..No histologic injury was found in the heart or kidney. In this porcine model of neonatal hypoxia and 100% reoxygenation, NAC improved cardiac function and renal perfusion, with improved tissue glutathione content...
  24. doi Increased relative mortality in women with severe oxygen-dependent COPD
    Magnus Ekström
    Department of Respiratory Medicine, Blekinge Hospital, SE 37185 Karlskrona, Sweden
    Chest 137:31-6. 2010
    ..We aimed to analyze differences in relative mortality and cause-specific mortality between men and women on long-term oxygen therapy (LTOT) for COPD...
  25. ncbi Continuous pulse oximetry in acute hemiparetic stroke
    G Sulter
    Department of Neurology, Academisch Ziekenhuis Groningen, Postbus 30 001, 9700 RB, Groningen, The Netherlands
    J Neurol Sci 179:65-9. 2000
    ..The aim of this study was to assess the value of early continuous monitoring with pulse oximetry in detecting arterial oxygen desaturations in patients with acute hemiparetic stroke, and the effects of oxygen administration...
  26. doi Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes
    Rønnaug Solberg
    Department of Paediatric Research, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Pediatr Res 67:250-6. 2010
    ..MMP-, VEGF-, and TGFbeta-superfamily are vital for the development, growth, and functional integrity of most tissues and our data rise concern about both short- and long-term consequences of even a brief hyperoxic exposure...
  27. ncbi Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8
    Berit Holthe Munkeby
    Department of Pediatric Research, Rikhospitalet University Hospital, Oslo, Norway
    Pediatr Res 58:542-8. 2005
    ..Altogether, these data strongly suggest that caution must be taken when applying pure O2 to the newborn infant...
  28. ncbi Heliox and oxygen reduce infarct volume in a rat model of focal ischemia
    Yi Pan
    Department of Neurology, Saint Louis University Hospital, 3635 Vista Ave, Saint Louis, MO 63110, USA
    Exp Neurol 205:587-90. 2007
    ..This suggests that a greater benefit may accrue from heliox therapy...
  29. ncbi Survival and future need of long-term oxygen therapy for chronic obstructive pulmonary disease--gender differences
    Karl A Franklin
    Department of Respiratory Medicine, University Hospital, SE 901 85 Umea, Sweden
    Respir Med 101:1506-11. 2007
    ..This is probably due to the increased frequency of smoking in women compared with men and a higher susceptibility to develop severe hypoxaemia in women. The survival is better in women with long-term oxygen therapy than in men...
  30. pmc Oxygen targeting in preterm infants using the Masimo SET Radical pulse oximeter
    Ewen D Johnston
    Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
    Arch Dis Child Fetal Neonatal Ed 96:F429-33. 2011
    ..A pretrial clinical improvement project for the BOOST-II UK trial of oxygen saturation targeting revealed an artefact affecting saturation profiles obtained from the Masimo Set Radical pulse oximeter...
  31. ncbi Refining the role of oxygen administration during delivery room resuscitation: what are the future goals?
    Sam Richmond
    Sunderland Royal Hospital, Sunderland SR4 7TP, UK
    Semin Fetal Neonatal Med 13:368-74. 2008
    ..There are strong arguments in favour of a radical curtailment of the use of oxygen in resuscitation at birth, and for devoting resources to defining the margins of safety for its use in the neonatal period in general...
  32. doi Routine use of oxygen in the treatment of myocardial infarction: systematic review
    M Wijesinghe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Heart 95:198-202. 2009
    ..International guidelines recommend the routine use of oxygen therapy in the treatment of myocardial infarction (MI)...
  33. ncbi Retinopathy of prematurity in a tertiary care center--incidence, risk factors and outcome
    Sudha Chaudhari
    Division of Neonatology, Department of Pediatrics, KEM Hospital, Pune 411 011, India
    Indian Pediatr 46:219-24. 2009
    ..To study the incidence and risk factors predisposing to retinopathy of prematurity (ROP) and to assess the outcome after laser photocoagulation...
  34. doi Effects of N-acetylcysteine on intestinal reoxygenation injury in hypoxic newborn piglets resuscitated with 100% oxygen
    Scott T Johnson
    Department of Surgery, University of Alberta, Edmonton, Alta, Canada
    Neonatology 96:162-70. 2009
    ..N-Acetylcysteine (NAC) is a thiol-containing antioxidant which increases intracellular stores of glutathione...
  35. ncbi Delivery room intervention: improving the outcome
    Wade D Rich
    Division of Neonatology, University of California San Diego, 402 Dickenson Street, Suite 1 140, San Diego, CA 92103 8774, USA
    Clin Perinatol 37:189-202. 2010
    ..Well-designed clinical trials are still needed to further establish the most optimal resuscitation interventions...
  36. pmc Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxic newborn piglets
    Jiang qin Liu
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e15322. 2010
    ..We investigated whether NAC provides prolonged protective effect on hemodynamics and oxidative stress using a surviving swine model of neonatal asphyxia...
  37. ncbi Factors affecting oxygen delivery with bi-level positive airway pressure
    Andrew R Schwartz
    Respiratory Care, Ellison 401, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Respir Care 49:270-5. 2004
    ..We conducted this study to test the hypothesis that delivered oxygen concentration using this configuration is affected by the choice of leak port, oxygen injection site, and ventilator settings...
  38. ncbi Determinants of Fi,O2 with oxygen supplementation during noninvasive two-level positive pressure ventilation
    F Thys
    Emergency Dept, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur Respir J 19:653-7. 2002
    ..If inspiratory airway pressure levels are >12 cmH2O, oxygen flows should be at least 4 L x min(-1)...
  39. ncbi Retrospective evaluation of patient compliance in continuous oxygen therapy
    Hande Demirel
    Department of Pulmonary Diseases, Cerrahpasa School of Medicine, University of Istanbul, Istanbul, Turkey
    Respiration 70:149-53. 2003
    ..Prescription of continuous oxygen therapy (COT) for correct indications, adequate education of the patients, and a regular and sufficient oxygen intake are essential...
  40. doi Management of two pregnancies in a woman with mixed connective tissue disease, pulmonary fibrosis, frequent pneumothorax and oxygen inhalation therapy along with a published work review
    Tatsuji Hoshino
    Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, Japan
    J Obstet Gynaecol Res 34:613-8. 2008
    Two pregnancies in a woman on oxygen inhalation therapy before pregnancy, due to pulmonary fibrosis and frequent pneumothorax that are secondary to mixed connective tissue disease, were managed safely...
  41. pmc Short burst oxygen therapy after activities of daily living in the home in chronic obstructive pulmonary disease
    S J Quantrill
    Chest Clinic, Whipps Cross University Hospital, London E11 1NR, UK
    Thorax 62:702-5. 2007
    ..Short burst oxygen therapy (SBOT) is widely prescribed in the UK with little evidence of benefit. A study was performed to examine whether SBOT benefits patients when undertaking normal activities at home among those who already use it...
  42. ncbi Implementing an oxygen programme in hospitals in Papua New Guinea
    Sens Matai
    National Department of Health, School of Medicine and Health Sciences, University of PNG, Papua New Guinea
    Ann Trop Paediatr 28:71-8. 2008
    ..The ongoing training of clinical and engineering staff as well as two follow-up evaluations are described...
  43. pmc Treatment of respiratory failure in COPD
    Stephan Budweiser
    Center for Pneumology, Hospital Donaustauf, Donaustauf, Germany
    Int J Chron Obstruct Pulmon Dis 3:605-18. 2008
    ..Such studies might preferentially recruit patients with repeated hypercapnic decompensation or a high risk for death, while ensuring effective ventilation and the patients' adherence to therapy...
  44. ncbi Cost-effectiveness and efficacy in long-term oxygen therapy
    Annette Duck
    South Manchester University Hospital Trust
    Nurs Times 102:46-50. 2006
    ..Annette Duck reviews the use of long-term oxygen therapy and highlights the importance of assessment in selecting both patients and suitable delivery systems...
  45. pmc Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial
    James K Stoller
    Respiratory Institute, Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Chest 138:179-87. 2010
    ..The trial plans to enroll subjects with COPD with moderate hypoxemia at rest or desaturation with exercise and compare tailored oxygen therapy to no oxygen therapy...
  46. pmc Got a match? Home oxygen therapy in current smokers
    Y Lacasse
    Thorax 61:374-5. 2006
  47. pmc Predictors of mortality in patients with emphysema and severe airflow obstruction
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, and Section of Thoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Respir Crit Care Med 173:1326-34. 2006
    ..Limited data exist describing risk factors for mortality in patients having predominantly emphysema...
  48. pmc Changes in pulmonary arterial pressure in preterm infants with chronic lung disease
    N V Subhedar
    Neonatal Intensive Care Unit, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Arch Dis Child Fetal Neonatal Ed 82:F243-7. 2000
    ..Pulmonary arterial pressure (PAP) is raised in preterm infants with respiratory distress syndrome who subsequently develop chronic lung disease. The natural history of pulmonary hypertension in infants with chronic lung disease is unknown...
  49. ncbi Oxygen therapy in COPD: what do we know?
    M Bradley Drummond
    Am J Respir Crit Care Med 176:321-2. 2007
  50. pmc A pragmatic assessment of the placement of oxygen when given for exercise induced dyspnoea
    J W Killen
    Department of Respiratory Medicine, Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK
    Thorax 55:544-6. 2000
    ..It is uncertain whether patients with chronic obstructive pulmonary disease (COPD) given oxygen for symptom relief should be advised to use it before or after exertion...
  51. ncbi Oxygen toxicity in premature infants
    Barry Weinberger
    Department of Pediatrics Neonatology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Toxicol Appl Pharmacol 181:60-7. 2002
    ..These include limiting oxygen supplementation and light exposure, the use of antiinflammatory agents or antioxidants, and the use of room air in neonatal resuscitation...
  52. ncbi Hyperbaric oxygen for acute carbon monoxide poisoning
    Lindell K Weaver
    Department of Internal Medicine, Pulmonary and Critical Care Division, LDS Hospital, Salt Lake City, Utah 84143, USA
    N Engl J Med 347:1057-67. 2002
    ..Patients with acute carbon monoxide poisoning commonly have cognitive sequelae. We conducted a double-blind, randomized trial to evaluate the effect of hyperbaric-oxygen treatment on such cognitive sequelae...
  53. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  54. doi A randomized controlled trial of the effect of fixed-dose routine nocturnal oxygen supplementation on oxygen saturation in patients with acute stroke
    Christine Roffe
    Stroke Research Group, Keele University, Staffordshire, United Kingdom
    J Stroke Cerebrovasc Dis 19:29-35. 2010
    ..The aim of this study was to assess the effect of routine low-flow oxygen supplementation on oxygen saturation (SpO(2)) in patients with acute stroke...
  55. ncbi Physician practices for prescribing supplemental oxygen in the palliative care setting
    Elizabeth Stringer
    Department of Medicine, Queen Elizabeth II Health Sciences Centre, Capital District Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada
    J Palliat Care 20:303-7. 2004
    ..There was a wide range of perceived benefits to oxygen prescription. In conclusion, physician practices for prescribing supplemental oxygen in the palliative care setting are variable. Further research is needed...
  56. ncbi Advantages of oxygen inhalation therapy for postoperative pulmonary hypertension
    N Ohashi
    Department of Pediatrics Developmental Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Cardiol 26:90-2. 2005
    ..remained after surgery, oxygenation was continued for 15 months, which included a shift to at-home oxygen inhalation therapy (HOT)...
  57. ncbi Pulmonary hypertension and chronic obstructive pulmonary disease: a case for treatment
    Tim Higenbottam
    Clinical Science, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK
    Proc Am Thorac Soc 2:12-9. 2005
    ....
  58. ncbi Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1632-42. 2007
    ..Our data suggest that NBO may represent a promising strategy for acute stroke treatment...
  59. pmc Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation
    G E Carpagnano
    Institute of Respiratory Diseases, University of Bari, Italy
    Thorax 59:1016-9. 2004
    ....
  60. ncbi The effect of different doses of oxygen administration on oxygen saturation in patients with stroke
    Khalid Ali
    Springfield Unit, University Hospital of North Staffordshire, Staffordshire, UK
    Neurocrit Care 3:24-6. 2005
    ..The aim of this study was to assess the effects of different doses and routes of oxygen administration on oxygen saturation in patients with stroke...
  61. ncbi Achievement of targeted saturation values in extremely low gestational age neonates resuscitated with low or high oxygen concentrations: a prospective, randomized trial
    Raquel Escrig
    Neonatalogy Service, La Fe Infant Maternal University Hospital, Valencia, Spain
    Pediatrics 121:875-81. 2008
    ....
  62. ncbi Ambulatory oxygen therapy, exercise, and survival with advanced chronic obstructive pulmonary disease (the Nocturnal Oxygen Therapy Trial revisited)
    T L Petty
    University of Colorado Health Sciences Center, Denver 80218, USA
    Respir Care 45:204-11; discussion 211-3. 2000
    ..In addition, COT was associated with better survival and reduced hospitalizations, compared with NOT patients who were unable to increase their walking level...
  63. ncbi Oxygen-saturation targets and outcomes in extremely preterm infants
    Lisa Maree Askie
    Centre for Perinatal Health Services Research, University of Sydney, NSW, Australia
    N Engl J Med 349:959-67. 2003
    ..Anecdotal reports and uncontrolled observational studies have suggested that a higher oxygen-saturation range may be beneficial in terms of growth and development...
  64. ncbi Survival on long-term oxygen therapy in chronic airflow limitation: from evidence to outcomes in the routine clinical setting
    A J Crockett
    Respiratory Unit, Flinders Medical Centre and Flinders University, South Australia, Australia
    Intern Med J 31:448-54. 2001
    ....
  65. ncbi Use of heliox in patients with severe exacerbation of chronic obstructive pulmonary disease
    P Gerbeaux
    Service d accueil des urgences, Hopital de la Conception, Marseille, France
    Crit Care Med 29:2322-4. 2001
    ..To assess whether patients with chronic obstructive pulmonary disease treated with heliox have a better prognosis than those treated with standard therapy...
  66. ncbi A cautionary tale about supplemental oxygen: the albatross of neonatal medicine
    William A Silverman
    Pediatrics 113:394-6. 2004
  67. pmc Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation
    W Tin
    Department of Paediatrics, South Cleveland Hospital, Middlesbrough TS4 3BW, UK
    Arch Dis Child Fetal Neonatal Ed 84:F106-10. 2001
    ....
  68. ncbi Improved oxygen systems for childhood pneumonia: a multihospital effectiveness study in Papua New Guinea
    Trevor Duke
    Centre for International Child Health, Department of Paediatrics, University of Melbourne, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet 372:1328-33. 2008
    ..We studied the effect of an improved oxygen system on death rate in children with pneumonia in Papua New Guinea...
  69. ncbi Automated adjustment of inspired oxygen in preterm infants with frequent fluctuations in oxygenation: a pilot clinical trial
    Nelson Claure
    Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Pediatr 155:640-5.e1-2. 2009
    ..To assess the efficacy of a system for automated fraction of inspired oxygen (FiO(2)) adjustment in maintaining oxygen saturation (SpO(2)) within an intended range in preterm infants with spontaneous fluctuations in SpO(2)...
  70. ncbi Retinopathy of prematurity--risk factors
    Ved P Gupta
    Department of Ophthalmology, University College of Medical Sciences, GTB Hospital, Delhi, India
    Indian J Pediatr 71:887-92. 2004
    ..Improved survival of low birth weight, premature babies have increased the incidence of retinopathy of prematurity. This hospital-based, prospective, study was undertaken to determine its incidence and risk factors in our neonatal unit...
  71. pmc Oxygen therapy in chronic obstructive pulmonary disease
    Victor Kim
    Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Am Thorac Soc 5:513-8. 2008
    ..The goals of this article are to briefly describe the indications for chronic oxygen administration, the physiologic effects of treatment, and potential toxicities, as well as its effect on morbidity and mortality...
  72. pmc A double-blind, randomised, controlled Phase II trial of Heliox28 gas mixture in lung cancer patients with dyspnoea on exertion
    S H Ahmedzai
    Academic Palliative Medicine Unit, Clinical Sciences Division South, Royal Hallamshire Hospital, Glossop Rd, Sheffield S10 2JF, UK
    Br J Cancer 90:366-71. 2004
    ..01). When compared to medical air, breathing Heliox28 but not oxygen-enriched air gave a significant improvement in the exercise capability (P<0.0001), SaO(2) (P<0.05) and dyspnoea scores (VAS, P<0.05) of lung cancer patients...
  73. ncbi Bronchiolitis: assessment and evidence-based management
    Dominic A Fitzgerald
    Department of Respiratory Medicine, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
    Med J Aust 180:399-404. 2004
    ..On current evidence, nebulised adrenaline, inhaled and systemic corticosteroids, and inhaled bronchodilators do not have a role in the routine management of infants with bronchiolitis...
  74. ncbi Oxygen supply in rural africa: a personal experience
    G Schneider
    Worldwide Evangelisation for Christ International, Banjul, The Gambia
    Int J Tuberc Lung Dis 5:524-6. 2001
    ..The system becomes cost effective if a rural hospital needs more than 6 treatment days (1 l/min) of oxygen per month and can be considered in a setting where 6 hours of sunlight per day can be guaranteed...
  75. pmc One year period prevalence study of respiratory acidosis in acute exacerbations of COPD: implications for the provision of non-invasive ventilation and oxygen administration
    P K Plant
    Department of Respiratory Medicine, St James s University Hospital, Leeds LS9 7TF, UK
    Thorax 55:550-4. 2000
    ..This study aimed to determine the prevalence of respiratory acidosis in patients admitted with COPD, to draw inferences about oxygen therapy, and to determine the need for NIV services for acute COPD in typical UK hospitals...
  76. ncbi Histological changes in the alveolar structure of the rat lung after exposure to hyperoxia
    Mohamed Akram Al-Motabagani
    Department of Anatomy, College of Medicine, King Faisal University
    Ital J Anat Embryol 110:209-23. 2005
    ..It was concluded that supplemental O2 therapy should be serially monitored by continuous assessment of pulmonary functions...
  77. ncbi Influence of the oxygen delivery system on the quality of life of patients with chronic hypoxemia
    Suzana Erico Tanni
    Pulmonology Division, Universidade Estadual Paulista UNESP, State University of São Paulo Julio de Mesquita Filho School of Medicine of Botucatu, Botucatu, SP, Brasil
    J Bras Pneumol 33:161-7. 2007
    ....
  78. pmc Recently published papers: the Jekyll and Hyde of oxygen, neuromuscular blockade and good vibrations?
    Jonathan Ball
    General Intensive Care Unit, St George s Hospital, Blackshaw Road, London, UK
    Crit Care 11:108. 2007
    ..This issue's recently published papers commentary takes a long hard look at the surprisingly topically issue of oxygen. To give a balanced perspective, topical ventilatory studies are also discussed...
  79. ncbi Impact of noninvasive home ventilation on long-term survival in chronic hypercapnic COPD: a prospective observational study
    S Budweiser
    Center for Pneumology, Hospital Donaustauf, Donaustauf, Germany
    Int J Clin Pract 61:1516-22. 2007
    ..The long-term benefit from noninvasive ventilation (NIV) in chronic hypercapnic chronic obstructive pulmonary disease (COPD) remains uncertain...
  80. pmc Overnight prescription of oxygen in long term oxygen therapy: time to reconsider the guidelines?
    M Nisbet
    Green Lane Respiratory Services, Auckland City Hospital, University of Auckland, Auckland, New Zealand
    Thorax 61:779-82. 2006
    ....
  81. pmc Explaining adherence to supplemental oxygen therapy: the patient's perspective
    Mark A Earnest
    University of Colorado Health Sciences Center, Denver, Colo, USA
    J Gen Intern Med 17:749-55. 2002
    ..To describe and explain the patterns of adherence to supplemental oxygen in individuals with hypoxemic chronic obstructive pulmonary disease (COPD)...
  82. ncbi A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD
    Judy M Bradley
    Department of Respiratory Medicine, Belfast City Hospital, Belfast, Northern Ireland, BT9 7AB
    Chest 131:278-85. 2007
    ..To systematically review the short-term efficacy of ambulatory oxygen from single-assessment studies in COPD...
  83. ncbi Oxygen therapy for hypercapnic patients with chronic obstructive pulmonary disease and acute respiratory failure: a randomized, controlled pilot study
    Charles D Gomersall
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT
    Crit Care Med 30:113-6. 2002
    ..To investigate the effect of oxygen therapy on outcome and on symptomatic hypercapnia...
  84. ncbi Room-air resuscitation causes less damage to heart and kidney than 100% oxygen
    Maximo Vento
    Neonatal Research Unit, Servicio de Neonatologia, Hospital Universitario Materno Infantil La Fe, Avenida de Campanar 21, 46009 Valencia, Spain
    Am J Respir Crit Care Med 172:1393-8. 2005
    ..Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage...
  85. pmc Intrapulmonary percussive ventilation in acute exacerbations of COPD patients with mild respiratory acidosis: a randomized controlled trial [ISRCTN17802078]
    Frederic Vargas
    Département de Réanimation Médicale, Hopital Pellegrin Tripode, Bordeaux, France
    Crit Care 9:R382-9. 2005
    ....
  86. ncbi Reducing the frequency and severity of exacerbations of chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Clinical Sciences Centre, Longmoor Lane, Liverpool L9 7AL, UK
    Proc Am Thorac Soc 1:121-4. 2004
    ..Health status changes mirrored these effects. In summary, combination therapy can effectively prevent exacerbations in patients with more advanced COPD...
  87. ncbi Helium/oxygen mixture reduces the work of breathing at the end of the weaning process in patients with severe chronic obstructive pulmonary disease
    Jean Luc Diehl
    Services de Réanimation Médicale, Hôpitaux Européen Georges Pompidou, France
    Crit Care Med 31:1415-20. 2003
    ..To test the hypothesis that helium/oxygen mixture can reduce the work of breathing at the end of the weaning process in patients with chronic obstructive pulmonary disease...
  88. ncbi [Clinical and transcutaneous oxygen saturation characteristics in hospitalized infants with acute viral bronchiolitis]
    Fernanda M Rubin
    Pediatria, Universidade Federal do Rio Grande do Sul
    J Pediatr (Rio J) 79:435-42. 2003
    ..To describe the clinical characteristics of infants with acute viral bronchiolitis (AVB) and to assess the influence of oxygen desaturation time (DT) as a prognostic test to estimate the evolution of such patients...
  89. ncbi Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy
    Arnaud Chambellan
    Service de Pneumologie, CHU de Nantes, Boulevard Jacques Monod, 44093 Nantes Cedex 1, France
    Chest 128:1201-8. 2005
    ..This study describes the distribution and prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy (LTOT)...
  90. ncbi Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
    ..Cluster headache is a stereotyped form of primary headache that while common in terms of neurologic illnesses is much less common as a cause of disabling headache than migraine...
  91. ncbi Effects of maternal hyperoxia with and without normocapnia in uteroplacental and fetal Doppler studies
    M J Simchen
    Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel
    Ultrasound Obstet Gynecol 26:495-9. 2005
    ..We aimed to evaluate the effect of maternal hyperoxygenation with and without maintaining normocapnia on the fetal and uteroplacental circulations in healthy near-term human pregnancies...
  92. ncbi Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients
    Margareta Emtner
    Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 168:1034-42. 2003
    ..001). We conclude that supplemental oxygen provided during high-intensity training yields higher training intensity and evidence of gains in exercise tolerance in laboratory testing...
  93. ncbi Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen
    Maximo Vento
    School of Medicine, University of Alicante, Department of Pediatrics and Neonatology and Division of Neonatology, Hospital Virgen del Consuelo, Valencia, Spain
    J Pediatr 142:240-6. 2003
    ..Assays performed included: blood gases; reduced glutathione (GSH) and oxidized glutathione (GSSG) in whole blood; glutathione-related enzyme activities; and superoxide dismutase activity (SOD) in erythrocytes...
  94. ncbi Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three tests
    Sian E Turner
    Physiotherapy Department, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia
    Chest 126:766-73. 2004
    ..To investigate cardiorespiratory and dyspnea responses to incremental and self-paced exercise tests in patients with COPD...
  95. ncbi Sequential use of oxygen and bi-level ventilation for respiratory failure in cystic fibrosis
    Catherine J Dobbin
    Department of Respiratory Medicine, E 11 West, Royal Prince Alfred Hospital, Missenden Road, NSW 2050, Australia
    J Cyst Fibros 3:237-42. 2004
    ..Supplemental nocturnal oxygen is widely used for hypoxaemic respiratory failure in adults with CF...
  96. ncbi Effects of mechanical insufflation-exsufflation on respiratory parameters for patients with chronic airway secretion encumbrance
    João C Winck
    Pneumology Department, Hospital Sao Joao, Faculdade de Medicina, Universidade do Porto Porto, Portugal
    Chest 126:774-80. 2004
    ..To analyze the physiologic effects and tolerance of mechanical insufflation-exsufflation (MI-E) for patients with chronic ventilatory failure of various etiologies...
  97. ncbi Respiratory assessment in adults
    T Moore
    School of Health and Social Sciences, Middlesex University, Middlesex
    Nurs Stand 21:48-56; quiz 58. 2007
    ..This article highlights the role of the nurse in respiratory assessment and discusses the implications of clinical findings...
  98. ncbi Home oxygen therapy: the jury is still in session
    Ann C Halbower
    J Perinatol 24:59-61. 2004
  99. ncbi The controversies surrounding oxygen therapy in neonatal intensive care units
    Sunil K Sinha
    The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, United Kingdom
    Curr Opin Pediatr 15:161-5. 2003
    ..This article provides the physiological rationale and evidence from recent clinical studies suggesting that keeping the oxygen therapy to an "acceptable" minimum in premature babies does not do any harm and may be even advantageous...
  100. ncbi Infants with bronchopulmonary dysplasia suckle with weak pressures to maintain breathing during feeding
    Katsumi Mizuno
    Showa University of Medicine, Department of Pediatrics, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Pediatrics 120:e1035-42. 2007
    ..The aim of this study was to determine whether the severity of bronchopulmonary dysplasia affects not only coordination among suck-swallow-respiration but also sucking endurance and performance itself...
  101. ncbi Non-invasive ventilation in COPD 1: Managing exacerbations
    Donna Barnes
    Pilgrims Hospice, Canterbury
    Nurs Times 103:26-7. 2007
    ..Part 1 examines how an exacerbation of COPD can lead to hypercapnic respiratory failure and how this might be managed...

Research Grants123 found, 100 shown here

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Neil Finer; Fiscal Year: 2005
    ..abstract_text> ..
  2. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Neil Finer; Fiscal Year: 2007
    ..abstract_text> ..
  3. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
    ..These studies should have immediate impact on treatment strategies for large poor-prognosis subgroups of COPD patients. ..
  4. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2003
    ..These studies should have immediate impact on treatment strategies for large poor-prognosis subgroups of COPD patients. ..
  5. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh Singhal; Fiscal Year: 2008
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  6. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh Singhal; Fiscal Year: 2006
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  7. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2001
    ..abstract_text> ..
  8. Rapid Clinical Snapshots from the EMR among Pneumonia Patients
    Gabriel J Escobar; Fiscal Year: 2010
    ....
  9. HOW MUCH DOES SHE REALLY DRINK--HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 1999
    ..abstract_text> ..
  10. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Fernando Martinez; Fiscal Year: 2008
    ..This will become particularly important if translational research is to keep pace as strides are made in the basic immunology, genetics and biochemistry of IPF. ..
  11. NICHD Cooperative Multicenter Neonatal Research Network
    Michele Walsh; Fiscal Year: 2007
    ....
  12. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2001
    ..abstract_text> ..
  13. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2005
    ..abstract_text> ..
  14. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2002
    ..abstract_text> ..
  15. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2008
    ..These protocols will define the role of standard therapy, test the efficacy of targeted combination therapy, and explore the promise of a novel approach to the design and delivery of therapeutic agents for IPF. (End of Abstract) ..
  16. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  17. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2005
    ..These protocols will define the role of standard therapy, test the efficacy of targeted combination therapy, and explore the promise of a novel approach to the design and delivery of therapeutic agents for IPF. (End of Abstract) ..
  18. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2004
    ..abstract_text> ..
  19. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2003
    ..abstract_text> ..
  20. NICHD Cooperative Multicenter Neonatal Research Network
    Michele Walsh; Fiscal Year: 2006
    ....
  21. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2007
    ..These protocols will define the role of standard therapy, test the efficacy of targeted combination therapy, and explore the promise of a novel approach to the design and delivery of therapeutic agents for IPF. (End of Abstract) ..
  23. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2007
    ..abstract_text> ..
  24. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh B Singhal; Fiscal Year: 2010
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  25. Rapid Clinical Snapshots from the EMR among Pneumonia Patients
    GABRIEL ESCOBAR; Fiscal Year: 2009
    ....
  26. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh Singhal; Fiscal Year: 2007
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  27. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Fernando Martinez; Fiscal Year: 2007
    ..This will become particularly important if translational research is to keep pace as strides are made in the basic immunology, genetics and biochemistry of IPF. ..
  28. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2006
    ..abstract_text> ..
  30. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2000
    ..abstract_text> ..
  31. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh Singhal; Fiscal Year: 2009
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  32. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. Collaborative Pediatric Critical Care Research Network
    Kathleen Meert; Fiscal Year: 2007
    ..Aim 3 will evaluate risk factors for pathological grief, psychological distress and marital dysfunction, and the effect of the postmortem conference in the identified high-risk groups. ..
  34. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2007
    ..Understanding these mechanisms that cause pathologic VEGF164 expression will provide potential strategies to prevent IVNV and to facilitate regression of IVNV and promote VPAR. ..
  35. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2008
    ..Understanding these mechanisms that cause pathologic VEGF164 expression will provide potential strategies to prevent IVNV and to facilitate regression of IVNV and promote VPAR. ..
  36. End-of-life Care for Chronic Lung Disease and Acute Respiratory Failure
    J Curtis; Fiscal Year: 2008
    ..3. Evaluate the stability of changes in the above outcomes over a 3 month period. 4. Evaluate the efficacy of the intervention for improving physician-nurse collaboration. ..
  37. ANTECEDENTS TO LUNG INJURY IN THE PRETERM
    Alan Jobe; Fiscal Year: 2005
    ..Finally, the ventilation and surfactant strategies that are found to cause the least injury will be tested to see if the arrest in lung development can be prevented. ..
  38. MRI and MRS Correlates of Cognitive Function in SLE
    Elizabeth Kozora; Fiscal Year: 2004
    ..This will better prepare clinicians with clear diagnostic avenues and better treatment options in the future. ..
  39. Role of Angiogenic Agents in Alveolar Maturation and Injury
    Vineet Bhandari; Fiscal Year: 2009
    ....
  40. NEW MEDIATORS OF CLINICAL LUNG MATURATION
    Alan Jobe; Fiscal Year: 2004
    ..A goal is to identify a mediator with potential for clinical use to induce lung maturation. ..
  41. GERIATRIC CLINICAL EPIDEMIOLOGY TRAINING GRANT
    STEVEN HALBERT; Fiscal Year: 2007
    ..g., clinical trials, case control, cohort research, etc.), and the faculties' commitment to collaborative research. [unreadable] [unreadable]..
  42. COGNITIVE EFFECTS OF LUNG VOLUME REDUCTION SURGERY
    Elizabeth Kozora; Fiscal Year: 2004
    ..Forty normal controls will be tested at baseline and 6-10 weeks follow- up. ..
  43. Reducing Mortality from Acute Hemorrhage in Trauma
    John Hess; Fiscal Year: 2006
    ..Reducing death from acute hemorrhage in trauma care will be a major step forward in reducing overall trauma mortality. ..
  44. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    JOHN WEG; Fiscal Year: 2003
    ..of lives lost from underdiagnosis, and major bleeding from overdiagnosis; 2) the potential applicability of a OF A NEW TECHNOLOGY FOR THE DIAGNOSIS OF PE THAT WILL HAVE WIDESPREAD AVAILABILITY; AND 3) THE INVESTIGATION ..
  45. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  46. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2005
    ..Specific Aim 2. Determine the severity of CNS injury by in vivo & ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..
  47. Force Propagation of Emphysema in Vivo
    Edward Ingenito; Fiscal Year: 2006
    ..The results of these experiments will provide new insight into the role of mechanical forces in promoting injury in the intact emphysema lung, and the effect of mechanical forces on tissue remodeling. [unreadable] [unreadable]..
  48. Force Propagation of Emphysema in Vivo
    Edward Ingenito; Fiscal Year: 2004
    ..The results of these experiments will provide new insight into the role of mechanical forces in promoting injury in the intact emphysema lung, and the effect of mechanical forces on tissue remodeling. ..
  49. Methylphenidate for Fatigue in Advanced Cancer Patients
    Eduardo Bruera; Fiscal Year: 2009
    ....
  50. Sleep Apnea: Upper Airway Nerve Injury
    Sigrid Veasey; Fiscal Year: 2009
    ..Collectively, the proposed studies will unveil important mechanisms of neuronal injury in obstructive sleep apnea and should reveal diabetes is a risk factor for this neural injury in sleep apnea. ..
  51. COGNITIVE EFFECTS OF LUNG VOLUME REDUCTION SURGERY
    Elizabeth Kozora; Fiscal Year: 2000
    ..Forty normal controls will be tested at baseline and 6-10 weeks follow- up. ..
  52. Respiratory and Metabolic Adaptation to Hypoxia
    Paul Schumacker; Fiscal Year: 2009
    ..Collectively, these studies will provide new information regarding the mechanisms of oxygen sensing in cells, which is important in normal tissues and in disease states. ..
  53. LUNG VOLUME REDUCTION USING A BRONCHOSCOPIC APPROACH
    Edward Ingenito; Fiscal Year: 1999
    ..The objective of this proposal is to test this hypothesis, and develop bronchoscopic volume reduction to such an extent that it could be considered for human trials. ..
  54. Pneumografting - a novel cell-based therapy for emphysema
    Edward Ingenito; Fiscal Year: 2008
    ..We intend to advance this approach, known as pneumografting, into human trials under a physician-sponsored Investigation New Drug Application. ..
  55. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2010
    ....
  56. MOLECULAR NEUROIMAGING OF AIDS DEMENTIA--ANIMAL MODELS
    Ramon Gonzalez; Fiscal Year: 2001
    ..The relationship of viral infection in the brain to metabolic and pathological abnormalities subsequently observed will be determined. ..
  57. COGNITIVE EFFECTS OF LUNG VOLUME REDUCTION SURGERY
    Elizabeth Kozora; Fiscal Year: 2002
    ..Forty normal controls will be tested at baseline and 6-10 weeks follow- up. ..
  58. Improving Physician Skill at Providing End-of-Life Care
    J Curtis; Fiscal Year: 2004
    ..The results will allow investigators and others to develop targeted educational and systemic interventions to improve the quality of this care. ..
  59. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
    ..This research will use clinically relevant prenatal exposures and postnatal sensitization to establish under controlled conditions any link between antenatal inflammation and the hygiene hypothesis. [unreadable] [unreadable] [unreadable]..
  60. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2009
    ..Specific Aim 2. Determine the severity of CNS injury by in vivo &ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..
  61. PATHOPHYSIOLOGY OF EXERCISE INDUCED ASTHMA
    EDWARD MCFADDEN; Fiscal Year: 2002
    ..abstract_text> ..
  62. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2002
    ....
  63. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2009
    ....
  64. C1q-complement and hypoxic-ischemic injury in the developing brain.
    Vadim S Ten; Fiscal Year: 2010
    ....
  65. Role of Angiogenic Agents in Alveolar Maturation and Injury
    Vineet Bhandari; Fiscal Year: 2010
    ....
  66. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  67. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2009
    ....
  68. Defining Acute Exacerbations of Idiopathic Pulmonary Fibrosis
    Harold Collard; Fiscal Year: 2008
    ..These skills will allow me to fully realize the power of clinical research to inform basic biology and advance medical knowledge. ..
  69. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2008
    ..Specific Aim 2. Determine the severity of CNS injury by in vivo & ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..
  70. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2007
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  71. Oxygen, Oxidant Stress and Wheezing in Premature Infants
    Timothy Stevens; Fiscal Year: 2008
    ..By evaluating the effect of oxygen exposure on oxidant stress and airway dysfunction this award will identify new therapeutic approaches to improve respiratory health of preterm infants in early childhood. ..
  72. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2008
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  73. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ....
  74. A Multifaceted Prompting Intervention for Urban Children With Asthma
    Jill Halterman; Fiscal Year: 2009
    ..Should it prove successful in reducing symptoms and improving the health of urban children with asthma, it has the potential to serve as a model for improved asthma care in urban communities. ..
  75. C1q-complement and hypoxic-ischemic injury in the developing brain.
    VADIM TEN; Fiscal Year: 2009
    ....
  76. School-Based Asthma Therapy: Stage 2 Effectiveness Study Revised
    Jill Halterman; Fiscal Year: 2009
    ..Should it prove successful in reducing symptoms and improving the health of young urban children with asthma, it has the potential to serve as a model for improved asthma care in urban communities. ..
  77. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  78. C1q-complement and hypoxic-ischemic injury in the developing brain.
    VADIM TEN; Fiscal Year: 2007
    ....
  79. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2002
    ..abstract_text> ..
  80. PATHOPHYSIOLOGY OF EXERCISE INDUCED ASTHMA
    EDWARD MCFADDEN; Fiscal Year: 2000
    ..abstract_text> ..
  81. PATHOPHYSIOLOGY OF EXERCISE INDUCED ASTHMA
    EDWARD MCFADDEN; Fiscal Year: 2001
    ..abstract_text> ..
  82. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2001
    ..abstract_text> ..
  83. ADVANCED MR SPECTROSCOPY OF SIV BRAIN INJURY
    Ramon Gonzalez; Fiscal Year: 2000
    ..In other experiments, the animals will be treated after infection. These studies have been simplified since the prior submission. They will begin on Year 02 of the grant. ..
  84. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2000
    ..abstract_text> ..
  85. ADVANCED MR SPECTROSCOPY OF SIV BRAIN INJURY
    Ramon Gonzalez; Fiscal Year: 1999
    ..In other experiments, the animals will be treated after infection. These studies have been simplified since the prior submission. They will begin on Year 02 of the grant. ..
  86. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 1999
    ..abstract_text> ..
  87. MOLECULAR NEUROIMAGING OF AIDS DEMENTIA--ANIMAL MODELS
    Ramon Gonzalez; Fiscal Year: 1999
    ..The relationship of viral infection in the brain to metabolic and pathological abnormalities subsequently observed will be determined. ..
  88. MOLECULAR NEUROIMAGING OF AIDS DEMENTIA--ANIMAL MODELS
    Ramon Gonzalez; Fiscal Year: 2002
    ..The relationship of viral infection in the brain to metabolic and pathological abnormalities subsequently observed will be determined. ..
  89. PATHOPHYSIOLOGY OF EXERCISE INDUCED ASTHMA
    EDWARD MCFADDEN; Fiscal Year: 2003
    ..abstract_text> ..
  90. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  91. Oxygen, Oxidant Stress and Wheezing in Premature Infants
    Timothy Stevens; Fiscal Year: 2007
    ..By evaluating the effect of oxygen exposure on oxidant stress and airway dysfunction this award will identify new therapeutic approaches to improve respiratory health of preterm infants in early childhood. ..
  92. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2007
    ..unreadable] [unreadable]..