oxygen inhalation therapy

Summary

Summary: Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)

Top Publications

  1. ncbi Benefits of oxygen on exercise performance and pulmonary hemodynamics in patients with COPD with mild hypoxemia
    Keisaku Fujimoto
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Chest 122:457-63. 2002
  2. ncbi Managing acute respiratory failure during exacerbation of chronic obstructive pulmonary disease
    Greg L Schumaker
    Pulmonary, Critical Care, and Sleep Division, Tufts New England Medical Center, Boston, Massachusetts, USA
    Respir Care 49:766-82. 2004
  3. ncbi Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study
    James I Hagadorn
    Division of Neonatology, Connecticut Children s Medical Center, 282 Washington St, Hartford, CT 06106, USA
    Pediatrics 118:1574-82. 2006
  4. pmc Target ranges of oxygen saturation in extremely preterm infants
    Waldemar A Carlo
    N Engl J Med 362:1959-69. 2010
  5. ncbi Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
  6. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010
  7. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
  8. pmc NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Parramatta Road, Camperdown, 2050, Australia
    BMC Pediatr 11:6. 2011
  9. ncbi Randomised trial of ambulatory oxygen in oxygen-dependent COPD
    Y Lacasse
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Eur Respir J 25:1032-8. 2005
  10. ncbi Definitions and diagnostic criteria for bronchopulmonary dysplasia
    Eduardo Bancalari
    Division of Newborn Medicine, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
    Semin Perinatol 30:164-70. 2006

Research Grants

  1. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
  2. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2007
  3. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh B Singhal; Fiscal Year: 2010
  4. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2003
  5. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2008
  6. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2007
  7. Systematic Reviews in Urologic Diseases
    Timothy Wilt; Fiscal Year: 2008
  8. Palliative Oxygen for the Relief of Breathlessness
    Amy Abernethy; Fiscal Year: 2007
  9. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
  10. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007

Detail Information

Publications235 found, 100 shown here

  1. ncbi Benefits of oxygen on exercise performance and pulmonary hemodynamics in patients with COPD with mild hypoxemia
    Keisaku Fujimoto
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Chest 122:457-63. 2002
    ..To clarify the effects of oxygen on exercise performance and pulmonary hemodynamics during exercise in patients with COPD with mild hypoxemia at rest...
  2. ncbi Managing acute respiratory failure during exacerbation of chronic obstructive pulmonary disease
    Greg L Schumaker
    Pulmonary, Critical Care, and Sleep Division, Tufts New England Medical Center, Boston, Massachusetts, USA
    Respir Care 49:766-82. 2004
    ..For invasively ventilated patients the clinical emphasis should be on improving patient-ventilator interaction and avoiding dynamic hyperinflation (intrinsic positive end-expiratory pressure)...
  3. ncbi Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study
    James I Hagadorn
    Division of Neonatology, Connecticut Children s Medical Center, 282 Washington St, Hartford, CT 06106, USA
    Pediatrics 118:1574-82. 2006
    ....
  4. pmc Target ranges of oxygen saturation in extremely preterm infants
    Waldemar A Carlo
    N Engl J Med 362:1959-69. 2010
    ..However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes...
  5. ncbi Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
    ..Cluster headache is a stereotyped form of primary headache that while common in terms of neurologic illnesses is much less common as a cause of disabling headache than migraine...
  6. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010
    ..If progressive high altitude acclimatization would not be possible, prophylaxis with nifedipine or tadalafil for long sojourns at high altitude or dexamethasone for a short stay of less then 5 days should be recommended...
  7. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  8. pmc NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Parramatta Road, Camperdown, 2050, Australia
    BMC Pediatr 11:6. 2011
    ..In order to answer this clinical dilemma reliably, large scale trial evidence is needed...
  9. ncbi Randomised trial of ambulatory oxygen in oxygen-dependent COPD
    Y Lacasse
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Eur Respir J 25:1032-8. 2005
    ..Ambulatory oxygen had no effect on any of the outcomes. In conclusion, the current results do not support the widespread provision of ambulatory oxygen to patients with oxygen-dependent chronic obstructive pulmonary disease...
  10. ncbi Definitions and diagnostic criteria for bronchopulmonary dysplasia
    Eduardo Bancalari
    Division of Newborn Medicine, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
    Semin Perinatol 30:164-70. 2006
    ..In view of all these shortcomings, it is essential to develop more objective physiologic tools to define the degree of lung damage and improve the prediction for long-term outcome in these infants...
  11. pmc Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial
    James K Stoller
    Respiratory Institute, Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Chest 138:179-87. 2010
    ..The trial plans to enroll subjects with COPD with moderate hypoxemia at rest or desaturation with exercise and compare tailored oxygen therapy to no oxygen therapy...
  12. ncbi Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy
    S Marti
    Servei de Pneumologia, Hospital General Vall d Hebron, and Laobratori de Bioestadística i Epidemiologia, Universitat Autonoma de Barcelona, Spain
    Eur Respir J 27:689-96. 2006
    ..These factors should be taken into account when considering the management and prognosis of these patients...
  13. ncbi Survival on long-term oxygen therapy in chronic airflow limitation: from evidence to outcomes in the routine clinical setting
    A J Crockett
    Respiratory Unit, Flinders Medical Centre and Flinders University, South Australia, Australia
    Intern Med J 31:448-54. 2001
    ....
  14. ncbi Noninvasive positive-pressure ventilation in patients with milder chronic obstructive pulmonary disease exacerbations: a randomized controlled trial
    Sean P Keenan
    Sean P Keenan MD, Suite 103, 250 Keary Street, New Westminster, British Columbia, V3L 5E7, Canada
    Respir Care 50:610-6. 2005
    ....
  15. ncbi Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease
    Maximo Vento
    Department of Pediatrics, Neonatal Research Unit, Division of Neonatology, University Hospital La Fe, Valencia, Spain
    Pediatrics 124:e439-49. 2009
    ..The goal was to reduce adverse pulmonary adverse outcomes, oxidative stress, and inflammation in neonates of 24 to 28 weeks of gestation initially resuscitated with fractions of inspired oxygen of 30% or 90%...
  16. ncbi Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    Aneesh B Singhal
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 58:945-52. 2002
    ..Hyperbaric oxygen therapy is considered an important stroke treatment strategy...
  17. pmc Meeting oxygen needs in Africa: an options analysis from the Gambia
    Stephen R C Howie
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, Gambia
    Bull World Health Organ 87:763-71. 2009
    ..To compare oxygen supply options for health facilities in the Gambia and develop a decision-making algorithm for choosing oxygen delivery systems in Africa and the rest of the developing world...
  18. ncbi Drugs (including oxygen) in severe COPD
    P Albert
    Division of Infection and Immunity, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
    Eur Respir J 31:1114-24. 2008
    ..Ambulatory oxygen improves exercise capacity, but whether it is used appropriately is in doubt. Overall, short burst oxygen therapy does not offer a benefit and therefore cannot be recommended...
  19. ncbi Compliance with LTOT and consumption of mobile oxygen
    T Ringbaek
    Department of Internal Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark
    Respir Med 93:333-7. 1999
    ..Using lists referring to the actual usage and discussing the usage with the patients may improve the compliance and cost-benefit...
  20. ncbi Oxygen for treatment of severe pneumonia in The Gambia, West Africa: a situational analysis
    S E Hill
    Department of Public Health, University of Otago, Wellington, New Zealand
    Int J Tuberc Lung Dis 13:587-93. 2009
    ..Health facilities in The Gambia, West Africa...
  21. ncbi Implementing an oxygen programme in hospitals in Papua New Guinea
    Sens Matai
    National Department of Health, School of Medicine and Health Sciences, University of PNG, Papua New Guinea
    Ann Trop Paediatr 28:71-8. 2008
    ..The ongoing training of clinical and engineering staff as well as two follow-up evaluations are described...
  22. pmc Treatment of respiratory failure in COPD
    Stephan Budweiser
    Center for Pneumology, Hospital Donaustauf, Donaustauf, Germany
    Int J Chron Obstruct Pulmon Dis 3:605-18. 2008
    ..Such studies might preferentially recruit patients with repeated hypercapnic decompensation or a high risk for death, while ensuring effective ventilation and the patients' adherence to therapy...
  23. ncbi Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients
    Margareta Emtner
    Rehabilitation Clinical Trials Center, Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 168:1034-42. 2003
    ..001). We conclude that supplemental oxygen provided during high-intensity training yields higher training intensity and evidence of gains in exercise tolerance in laboratory testing...
  24. ncbi A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD
    Judy M Bradley
    Department of Respiratory Medicine, Belfast City Hospital, Belfast, Northern Ireland, BT9 7AB
    Chest 131:278-85. 2007
    ..To systematically review the short-term efficacy of ambulatory oxygen from single-assessment studies in COPD...
  25. pmc Long-term morbidity and mortality following hypoxaemic lower respiratory tract infection in Gambian children
    T E West
    Medical College of Virginia, Richmond, USA
    Bull World Health Organ 77:144-8. 1999
    ..Survival depends more on nutritional status than on having been hypoxaemic. Investment in oxygen therapy appears justified, and efforts should be made to improve nutrition in malnourished children with pneumonia...
  26. pmc Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?
    G Klinger
    Division of Neonatology, Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Dis Child Fetal Neonatal Ed 90:F49-52. 2005
    ..Episodes of hyperoxaemia and hypocapnia, which may contribute to brain injury, occur unintentionally in severely asphyxiated neonates in the first postnatal hours...
  27. ncbi Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients
    A Somfay
    Rehabilitation Clinical Trials Center, Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA
    Eur Respir J 18:77-84. 2001
    ..This effect is maximized at an inspired oxygen fraction of 0.5...
  28. ncbi N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen
    Scott T Johnson
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Shock 28:484-90. 2007
    ..No histologic injury was found in the heart or kidney. In this porcine model of neonatal hypoxia and 100% reoxygenation, NAC improved cardiac function and renal perfusion, with improved tissue glutathione content...
  29. ncbi Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes
    Rønnaug Solberg
    Department of Paediatric Research, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Pediatr Res 67:250-6. 2010
    ..MMP-, VEGF-, and TGFbeta-superfamily are vital for the development, growth, and functional integrity of most tissues and our data rise concern about both short- and long-term consequences of even a brief hyperoxic exposure...
  30. ncbi Increased relative mortality in women with severe oxygen-dependent COPD
    Magnus Ekström
    Department of Respiratory Medicine, Blekinge Hospital, SE 37185 Karlskrona, Sweden
    Chest 137:31-6. 2010
    ..We aimed to analyze differences in relative mortality and cause-specific mortality between men and women on long-term oxygen therapy (LTOT) for COPD...
  31. ncbi Continuous pulse oximetry in acute hemiparetic stroke
    G Sulter
    Department of Neurology, Academisch Ziekenhuis Groningen, Postbus 30 001, 9700 RB, Groningen, The Netherlands
    J Neurol Sci 179:65-9. 2000
    ..The aim of this study was to assess the value of early continuous monitoring with pulse oximetry in detecting arterial oxygen desaturations in patients with acute hemiparetic stroke, and the effects of oxygen administration...
  32. ncbi [Clinical and transcutaneous oxygen saturation characteristics in hospitalized infants with acute viral bronchiolitis]
    Fernanda M Rubin
    Pediatria, Universidade Federal do Rio Grande do Sul
    J Pediatr (Rio J) 79:435-42. 2003
    ..To describe the clinical characteristics of infants with acute viral bronchiolitis (AVB) and to assess the influence of oxygen desaturation time (DT) as a prognostic test to estimate the evolution of such patients...
  33. ncbi Short-burst oxygen therapy in chronic obstructive pulmonary disease
    Brenda O'Neill
    Health and Rehabilitation Research Institute, School of Health Sciences, University of Ulster, Shore Rd Newtownabbey, Co Antrim, BT37 OQB, Northern Ireland
    Respir Med 100:1129-38. 2006
    ..Despite widespread prescription, the efficacy of short-burst oxygen therapy has not been established...
  34. ncbi Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea
    Takuji Toyama
    Gunma Prefectural Cardiovascular Center, Maebashi, Japan
    Circ J 73:299-304. 2009
    ..Central sleep apnea, often found in patients with chronic heart failure (CHF), has a high risk of poor prognosis...
  35. pmc One year period prevalence study of respiratory acidosis in acute exacerbations of COPD: implications for the provision of non-invasive ventilation and oxygen administration
    P K Plant
    Department of Respiratory Medicine, St James s University Hospital, Leeds LS9 7TF, UK
    Thorax 55:550-4. 2000
    ..This study aimed to determine the prevalence of respiratory acidosis in patients admitted with COPD, to draw inferences about oxygen therapy, and to determine the need for NIV services for acute COPD in typical UK hospitals...
  36. ncbi The potential impact of anaemia of chronic disease in COPD
    T Similowski
    Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and UPRES EA2397 Université Paris VI Pierre et Marie Curie, Paris, France
    Eur Respir J 27:390-6. 2006
    ..When this body of knowledge is available, the question of the putative benefits of raising haemoglobinaemia in chronic obstructive pulmonary disease will have to be addressed...
  37. ncbi Hypoxaemia in children with severe pneumonia in Papua New Guinea
    T Duke
    Goroka Base Hospital, Eastern Highlands Province, Papua New Guinea
    Int J Tuberc Lung Dis 5:511-9. 2001
    ....
  38. ncbi Ambulatory oxygen improves quality of life of COPD patients: a randomised controlled study
    T Eaton
    Dept of Respiratory Services, Green Lane Hospital, Auckland, New Zealand
    Eur Respir J 20:306-12. 2002
    ..These benefits cannot be predicted by baseline characteristics or acute response. Despite acute or short-term response, a substantial proportion of patients declined ambulatory oxygen...
  39. ncbi Quality of life and social-economic characteristics of greek male patients on long-term oxygen therapy
    Venetia Tsara
    2nd Chest Clinic, General Hospital, G Papanikolaou, Thessaloniki, Greece
    Respir Care 53:1048-53. 2008
    ..Chronic obstructive pulmonary disease (COPD) profoundly impacts patients' functional status, especially in the advanced stages, when long-term oxygen therapy (LTOT) is implemented...
  40. ncbi Retrospective evaluation of patient compliance in continuous oxygen therapy
    Hande Demirel
    Department of Pulmonary Diseases, Cerrahpasa School of Medicine, University of Istanbul, Istanbul, Turkey
    Respiration 70:149-53. 2003
    ..Prescription of continuous oxygen therapy (COT) for correct indications, adequate education of the patients, and a regular and sufficient oxygen intake are essential...
  41. pmc Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxic newborn piglets
    Jiang qin Liu
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e15322. 2010
    ..We investigated whether NAC provides prolonged protective effect on hemodynamics and oxidative stress using a surviving swine model of neonatal asphyxia...
  42. ncbi Refining the role of oxygen administration during delivery room resuscitation: what are the future goals?
    Sam Richmond
    Sunderland Royal Hospital, Sunderland SR4 7TP, UK
    Semin Fetal Neonatal Med 13:368-74. 2008
    ..There are strong arguments in favour of a radical curtailment of the use of oxygen in resuscitation at birth, and for devoting resources to defining the margins of safety for its use in the neonatal period in general...
  43. ncbi Delivery room intervention: improving the outcome
    Wade D Rich
    Division of Neonatology, University of California San Diego, 402 Dickenson Street, Suite 1 140, San Diego, CA 92103 8774, USA
    Clin Perinatol 37:189-202. 2010
    ..Well-designed clinical trials are still needed to further establish the most optimal resuscitation interventions...
  44. ncbi Factors affecting oxygen delivery with bi-level positive airway pressure
    Andrew R Schwartz
    Respiratory Care, Ellison 401, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Respir Care 49:270-5. 2004
    ..We conducted this study to test the hypothesis that delivered oxygen concentration using this configuration is affected by the choice of leak port, oxygen injection site, and ventilator settings...
  45. pmc Oxygen targeting in preterm infants using the Masimo SET Radical pulse oximeter
    Ewen D Johnston
    Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
    Arch Dis Child Fetal Neonatal Ed 96:F429-33. 2011
    ..A pretrial clinical improvement project for the BOOST-II UK trial of oxygen saturation targeting revealed an artefact affecting saturation profiles obtained from the Masimo Set Radical pulse oximeter...
  46. ncbi Determinants of Fi,O2 with oxygen supplementation during noninvasive two-level positive pressure ventilation
    F Thys
    Emergency Dept, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur Respir J 19:653-7. 2002
    ..If inspiratory airway pressure levels are >12 cmH2O, oxygen flows should be at least 4 L x min(-1)...
  47. ncbi Effects of N-acetylcysteine on intestinal reoxygenation injury in hypoxic newborn piglets resuscitated with 100% oxygen
    Scott T Johnson
    Department of Surgery, University of Alberta, Edmonton, Alta, Canada
    Neonatology 96:162-70. 2009
    ..N-Acetylcysteine (NAC) is a thiol-containing antioxidant which increases intracellular stores of glutathione...
  48. ncbi Retinopathy of prematurity in a tertiary care center--incidence, risk factors and outcome
    Sudha Chaudhari
    Division of Neonatology, Department of Pediatrics, KEM Hospital, Pune 411 011, India
    Indian Pediatr 46:219-24. 2009
    ..To study the incidence and risk factors predisposing to retinopathy of prematurity (ROP) and to assess the outcome after laser photocoagulation...
  49. ncbi Survival and future need of long-term oxygen therapy for chronic obstructive pulmonary disease--gender differences
    Karl A Franklin
    Department of Respiratory Medicine, University Hospital, SE 901 85 Umea, Sweden
    Respir Med 101:1506-11. 2007
    ..This is probably due to the increased frequency of smoking in women compared with men and a higher susceptibility to develop severe hypoxaemia in women. The survival is better in women with long-term oxygen therapy than in men...
  50. pmc Changes in pulmonary arterial pressure in preterm infants with chronic lung disease
    N V Subhedar
    Neonatal Intensive Care Unit, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Arch Dis Child Fetal Neonatal Ed 82:F243-7. 2000
    ..Pulmonary arterial pressure (PAP) is raised in preterm infants with respiratory distress syndrome who subsequently develop chronic lung disease. The natural history of pulmonary hypertension in infants with chronic lung disease is unknown...
  51. pmc Short burst oxygen therapy after activities of daily living in the home in chronic obstructive pulmonary disease
    S J Quantrill
    Chest Clinic, Whipps Cross University Hospital, London E11 1NR, UK
    Thorax 62:702-5. 2007
    ..Short burst oxygen therapy (SBOT) is widely prescribed in the UK with little evidence of benefit. A study was performed to examine whether SBOT benefits patients when undertaking normal activities at home among those who already use it...
  52. pmc A pragmatic assessment of the placement of oxygen when given for exercise induced dyspnoea
    J W Killen
    Department of Respiratory Medicine, Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK
    Thorax 55:544-6. 2000
    ..It is uncertain whether patients with chronic obstructive pulmonary disease (COPD) given oxygen for symptom relief should be advised to use it before or after exertion...
  53. pmc Got a match? Home oxygen therapy in current smokers
    Y Lacasse
    Thorax 61:374-5. 2006
  54. pmc Predictors of mortality in patients with emphysema and severe airflow obstruction
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, and Section of Thoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Respir Crit Care Med 173:1326-34. 2006
    ..Limited data exist describing risk factors for mortality in patients having predominantly emphysema...
  55. ncbi Impact of a physiologic definition on bronchopulmonary dysplasia rates
    Michele C Walsh
    Rainbow Babies and Childrens Hospital, Department of Pediatrics, CASE Case Western Reserve University, 11100 Euclid Ave, Mailstop 6010, Cleveland, OH 44106, USA
    Pediatrics 114:1305-11. 2004
    ..Safety (apnea, bradycardia, increased oxygen use) and outcomes of the physiologic definition versus the clinical definition were assessed...
  56. ncbi Hyperbaric oxygen for acute carbon monoxide poisoning
    Lindell K Weaver
    Department of Internal Medicine, Pulmonary and Critical Care Division, LDS Hospital, Salt Lake City, Utah 84143, USA
    N Engl J Med 347:1057-67. 2002
    ..Patients with acute carbon monoxide poisoning commonly have cognitive sequelae. We conducted a double-blind, randomized trial to evaluate the effect of hyperbaric-oxygen treatment on such cognitive sequelae...
  57. ncbi Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia
    Shimin Liu
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 26:1274-84. 2006
    ..These results suggest that maintaining penumbral oxygenation by normobaric oxygen treatment during ischemia lead to neuroprotection, which is further reflected by the decreased production of ROS, MMP-9, and caspase-8...
  58. ncbi Hypoxaemia among children in rural hospitals in Papua New Guinea: epidemiology and resource availability--a study to support a national oxygen programme
    Francis Wandi
    Department of Paediatrics, Kundiawa Hospital, Simbu Province, Papua New Guinea
    Ann Trop Paediatr 26:277-84. 2006
    ..We also established baseline mortality rate data for all children admitted to five hospitals, for children with a diagnosis of pneumonia and for neonates to evaluate a future intervention...
  59. ncbi A pilot study of normobaric oxygen therapy in acute ischemic stroke
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 36:797-802. 2005
    ..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke...
  60. ncbi Short-burst oxygen therapy for COPD patients: a 6-month randomised, controlled study
    T Eaton
    Respiratory Services, Auckland City Hospital, and Department of Medicine, Faculty of Health Sciences, University of Auckland, New Zealand
    Eur Respir J 27:697-704. 2006
    ..These results provide no support for the widespread use of short-burst oxygen therapy...
  61. ncbi Cost-effectiveness and efficacy in long-term oxygen therapy
    Annette Duck
    South Manchester University Hospital Trust
    Nurs Times 102:46-50. 2006
    ..Annette Duck reviews the use of long-term oxygen therapy and highlights the importance of assessment in selecting both patients and suitable delivery systems...
  62. ncbi Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis
    Peter G Davis
    Royal Women s Hospital, Melbourne, Australia
    Lancet 364:1329-33. 2004
    ..We aimed to establish whether resuscitation with air decreased mortality or neurological disability in newborn infants compared with 100% oxygen...
  63. ncbi Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8
    Berit Holthe Munkeby
    Department of Pediatric Research, Rikhospitalet University Hospital, Oslo, Norway
    Pediatr Res 58:542-8. 2005
    ..Altogether, these data strongly suggest that caution must be taken when applying pure O2 to the newborn infant...
  64. ncbi The demographics and economics of long-term oxygen therapy
    P J Dunne
    HomeTech Medical Services, Fullerton, CA 92832, USA
    Respir Care 45:223-8; discussion 228-30. 2000
    ..The net result would be that reimbursement dollars currently wasted on home oxygen equipment that is not being used could be reallocated for those patient-customers willing and able to use the equipment as prescribed...
  65. ncbi Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates
    M Vento
    Servicio de Pediatria, Hospital Virgen del Consuelo, Valencia, Spain
    Pediatrics 107:642-7. 2001
    ..Oxidative stress markers in moderately asphyxiated term newborn infants resuscitated with either 100% oxygen or room air have been studied for the first time in this work...
  66. pmc The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography
    S J Falk
    MRC Unit, Cambridge, UK
    Br J Cancer 66:919-24. 1992
    ..5 mmHg were only eliminated in three out of 11 tumours. The time course has implications for the planning of clinical trials utilising radiotherapy with carbogen breathing...
  67. ncbi Oxygen toxicity in premature infants
    Barry Weinberger
    Department of Pediatrics Neonatology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Toxicol Appl Pharmacol 181:60-7. 2002
    ..These include limiting oxygen supplementation and light exposure, the use of antiinflammatory agents or antioxidants, and the use of room air in neonatal resuscitation...
  68. ncbi Treatment and quality of life in patients with chronic obstructive pulmonary disease
    M Miravitlles
    Servei de Pneumologia, Hospital General Vall d Hebron, Barcelona, Spain
    Qual Life Res 11:329-38. 2002
    ..These findings suggest that the use of multiple drugs in the treatment of patients with COPD is associated with worse total SGRQ scores. The effect of drugs, their dosages and associations with other drugs on HRQL merit further research...
  69. ncbi Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: A prospective, multicenter study
    Philippe Jolliet
    Medical Intensive Care Division, University Hospital, Geneva, Switzerland
    Crit Care Med 31:878-84. 2003
    ....
  70. ncbi Management of two pregnancies in a woman with mixed connective tissue disease, pulmonary fibrosis, frequent pneumothorax and oxygen inhalation therapy along with a published work review
    Tatsuji Hoshino
    Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, Japan
    J Obstet Gynaecol Res 34:613-8. 2008
    Two pregnancies in a woman on oxygen inhalation therapy before pregnancy, due to pulmonary fibrosis and frequent pneumothorax that are secondary to mixed connective tissue disease, were managed safely...
  71. ncbi Routine use of oxygen in the treatment of myocardial infarction: systematic review
    M Wijesinghe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Heart 95:198-202. 2009
    ..International guidelines recommend the routine use of oxygen therapy in the treatment of myocardial infarction (MI)...
  72. ncbi Oxygen therapy in COPD: what do we know?
    M Bradley Drummond
    Am J Respir Crit Care Med 176:321-2. 2007
  73. ncbi Heliox and oxygen reduce infarct volume in a rat model of focal ischemia
    Yi Pan
    Department of Neurology, Saint Louis University Hospital, 3635 Vista Ave, Saint Louis, MO 63110, USA
    Exp Neurol 205:587-90. 2007
    ..This suggests that a greater benefit may accrue from heliox therapy...
  74. ncbi Characteristics of demand oxygen delivery systems: maximum output and setting recommendations
    Peter L Bliss
    Department of Pulmonary Critical Care Medicine, Regions Hospital, St Paul, Minnesota, USA
    Respir Care 49:160-5. 2004
    ..Because DODS conserve oxygen by various methods, there are important performance differences between DODS. We studied certain performance factors that have not previously been carefully examined...
  75. pmc The history of COPD
    Thomas L Petty
    University of Colorado Medical Center, Denver, CO, USA
    Int J Chron Obstruct Pulmon Dis 1:3-14. 2006
    ..Early identification and prevention, and treatment of emerging stages of disease through smoking cessation and a growing number of bronchoactive drugs promises to change the outcome...
  76. ncbi Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia
    Mika L Nonoyama
    West Park Healthcare Centre, 82 Buttonwood Avenue, Toronto, ON, M6M 2J5 Canada
    Am J Respir Crit Care Med 176:343-9. 2007
    ..Ambulatory oxygen improves acute exercise performance in people with chronic obstructive pulmonary disease (COPD). This improvement may not translate into symptomatic benefit for patients during activities of daily living...
  77. ncbi Physician practices for prescribing supplemental oxygen in the palliative care setting
    Elizabeth Stringer
    Department of Medicine, Queen Elizabeth II Health Sciences Centre, Capital District Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada
    J Palliat Care 20:303-7. 2004
    ..There was a wide range of perceived benefits to oxygen prescription. In conclusion, physician practices for prescribing supplemental oxygen in the palliative care setting are variable. Further research is needed...
  78. ncbi A randomized controlled trial of the effect of fixed-dose routine nocturnal oxygen supplementation on oxygen saturation in patients with acute stroke
    Christine Roffe
    Stroke Research Group, Keele University, Staffordshire, United Kingdom
    J Stroke Cerebrovasc Dis 19:29-35. 2010
    ..The aim of this study was to assess the effect of routine low-flow oxygen supplementation on oxygen saturation (SpO(2)) in patients with acute stroke...
  79. ncbi The effect of different doses of oxygen administration on oxygen saturation in patients with stroke
    Khalid Ali
    Springfield Unit, University Hospital of North Staffordshire, Staffordshire, UK
    Neurocrit Care 3:24-6. 2005
    ..The aim of this study was to assess the effects of different doses and routes of oxygen administration on oxygen saturation in patients with stroke...
  80. pmc Oxygen therapy in chronic obstructive pulmonary disease
    Victor Kim
    Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Am Thorac Soc 5:513-8. 2008
    ..The goals of this article are to briefly describe the indications for chronic oxygen administration, the physiologic effects of treatment, and potential toxicities, as well as its effect on morbidity and mortality...
  81. ncbi Achievement of targeted saturation values in extremely low gestational age neonates resuscitated with low or high oxygen concentrations: a prospective, randomized trial
    Raquel Escrig
    Neonatalogy Service, La Fe Infant Maternal University Hospital, Valencia, Spain
    Pediatrics 121:875-81. 2008
    ....
  82. ncbi Improved oxygen systems for childhood pneumonia: a multihospital effectiveness study in Papua New Guinea
    Trevor Duke
    Centre for International Child Health, Department of Paediatrics, University of Melbourne, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet 372:1328-33. 2008
    ..We studied the effect of an improved oxygen system on death rate in children with pneumonia in Papua New Guinea...
  83. ncbi Automated adjustment of inspired oxygen in preterm infants with frequent fluctuations in oxygenation: a pilot clinical trial
    Nelson Claure
    Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Pediatr 155:640-5.e1-2. 2009
    ..To assess the efficacy of a system for automated fraction of inspired oxygen (FiO(2)) adjustment in maintaining oxygen saturation (SpO(2)) within an intended range in preterm infants with spontaneous fluctuations in SpO(2)...
  84. ncbi Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1632-42. 2007
    ..Our data suggest that NBO may represent a promising strategy for acute stroke treatment...
  85. ncbi Oxygen-saturation targets and outcomes in extremely preterm infants
    Lisa Maree Askie
    Centre for Perinatal Health Services Research, University of Sydney, NSW, Australia
    N Engl J Med 349:959-67. 2003
    ..Anecdotal reports and uncontrolled observational studies have suggested that a higher oxygen-saturation range may be beneficial in terms of growth and development...
  86. pmc Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation
    G E Carpagnano
    Institute of Respiratory Diseases, University of Bari, Italy
    Thorax 59:1016-9. 2004
    ....
  87. ncbi Retinopathy of prematurity--risk factors
    Ved P Gupta
    Department of Ophthalmology, University College of Medical Sciences, GTB Hospital, Delhi, India
    Indian J Pediatr 71:887-92. 2004
    ..Improved survival of low birth weight, premature babies have increased the incidence of retinopathy of prematurity. This hospital-based, prospective, study was undertaken to determine its incidence and risk factors in our neonatal unit...
  88. ncbi Pulmonary hypertension and chronic obstructive pulmonary disease: a case for treatment
    Tim Higenbottam
    Clinical Science, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK
    Proc Am Thorac Soc 2:12-9. 2005
    ....
  89. pmc Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation
    W Tin
    Department of Paediatrics, South Cleveland Hospital, Middlesbrough TS4 3BW, UK
    Arch Dis Child Fetal Neonatal Ed 84:F106-10. 2001
    ....
  90. ncbi Advantages of oxygen inhalation therapy for postoperative pulmonary hypertension
    N Ohashi
    Department of Pediatrics Developmental Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Cardiol 26:90-2. 2005
    ..remained after surgery, oxygenation was continued for 15 months, which included a shift to at-home oxygen inhalation therapy (HOT)...
  91. ncbi Ambulatory oxygen therapy, exercise, and survival with advanced chronic obstructive pulmonary disease (the Nocturnal Oxygen Therapy Trial revisited)
    T L Petty
    University of Colorado Health Sciences Center, Denver 80218, USA
    Respir Care 45:204-11; discussion 211-3. 2000
    ..In addition, COT was associated with better survival and reduced hospitalizations, compared with NOT patients who were unable to increase their walking level...
  92. ncbi A cautionary tale about supplemental oxygen: the albatross of neonatal medicine
    William A Silverman
    Pediatrics 113:394-6. 2004
  93. ncbi Use of heliox in patients with severe exacerbation of chronic obstructive pulmonary disease
    P Gerbeaux
    Service d accueil des urgences, Hopital de la Conception, Marseille, France
    Crit Care Med 29:2322-4. 2001
    ..To assess whether patients with chronic obstructive pulmonary disease treated with heliox have a better prognosis than those treated with standard therapy...
  94. pmc A double-blind, randomised, controlled Phase II trial of Heliox28 gas mixture in lung cancer patients with dyspnoea on exertion
    S H Ahmedzai
    Academic Palliative Medicine Unit, Clinical Sciences Division South, Royal Hallamshire Hospital, Glossop Rd, Sheffield S10 2JF, UK
    Br J Cancer 90:366-71. 2004
    ..01). When compared to medical air, breathing Heliox28 but not oxygen-enriched air gave a significant improvement in the exercise capability (P<0.0001), SaO(2) (P<0.05) and dyspnoea scores (VAS, P<0.05) of lung cancer patients...
  95. ncbi Oxygen supply in rural africa: a personal experience
    G Schneider
    Worldwide Evangelisation for Christ International, Banjul, The Gambia
    Int J Tuberc Lung Dis 5:524-6. 2001
    ..The system becomes cost effective if a rural hospital needs more than 6 treatment days (1 l/min) of oxygen per month and can be considered in a setting where 6 hours of sunlight per day can be guaranteed...
  96. ncbi Bronchiolitis: assessment and evidence-based management
    Dominic A Fitzgerald
    Department of Respiratory Medicine, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
    Med J Aust 180:399-404. 2004
    ..On current evidence, nebulised adrenaline, inhaled and systemic corticosteroids, and inhaled bronchodilators do not have a role in the routine management of infants with bronchiolitis...
  97. pmc Overnight prescription of oxygen in long term oxygen therapy: time to reconsider the guidelines?
    M Nisbet
    Green Lane Respiratory Services, Auckland City Hospital, University of Auckland, Auckland, New Zealand
    Thorax 61:779-82. 2006
    ....
  98. ncbi Oxygen therapy for hypercapnic patients with chronic obstructive pulmonary disease and acute respiratory failure: a randomized, controlled pilot study
    Charles D Gomersall
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT
    Crit Care Med 30:113-6. 2002
    ..To investigate the effect of oxygen therapy on outcome and on symptomatic hypercapnia...
  99. pmc Recently published papers: the Jekyll and Hyde of oxygen, neuromuscular blockade and good vibrations?
    Jonathan Ball
    General Intensive Care Unit, St George s Hospital, Blackshaw Road, London, UK
    Crit Care 11:108. 2007
    ..This issue's recently published papers commentary takes a long hard look at the surprisingly topically issue of oxygen. To give a balanced perspective, topical ventilatory studies are also discussed...
  100. ncbi Impact of noninvasive home ventilation on long-term survival in chronic hypercapnic COPD: a prospective observational study
    S Budweiser
    Center for Pneumology, Hospital Donaustauf, Donaustauf, Germany
    Int J Clin Pract 61:1516-22. 2007
    ..The long-term benefit from noninvasive ventilation (NIV) in chronic hypercapnic chronic obstructive pulmonary disease (COPD) remains uncertain...
  101. ncbi Influence of the oxygen delivery system on the quality of life of patients with chronic hypoxemia
    Suzana Erico Tanni
    Pulmonology Division, Universidade Estadual Paulista UNESP, State University of São Paulo Julio de Mesquita Filho School of Medicine of Botucatu, Botucatu, SP, Brasil
    J Bras Pneumol 33:161-7. 2007
    ....

Research Grants62

  1. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
    ..These studies should have immediate impact on treatment strategies for large poor-prognosis subgroups of COPD patients. ..
  2. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  3. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh B Singhal; Fiscal Year: 2010
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  4. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2003
    ..abstract_text> ..
  5. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2007
    ..abstract_text> ..
  7. Systematic Reviews in Urologic Diseases
    Timothy Wilt; Fiscal Year: 2008
    ..This will provide rapid dissemination, enhances implementation, and identifies new areas requiring additional research. ..
  8. Palliative Oxygen for the Relief of Breathlessness
    Amy Abernethy; Fiscal Year: 2007
    ..The results will also advance a long-standing international debate about the role of palliative oxygen for intractable dyspnea and it's funding. [unreadable] [unreadable] [unreadable]..
  9. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
    ..2.3. Perfusion (BF) in the surgical incision on postoperative days 3, 5 and 9 using Laser Doppler Flowmetry (LDF). ..
  10. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007
    ..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
  11. Force Propagation of Emphysema in Vivo
    Edward Ingenito; Fiscal Year: 2007
    ..The results of these experiments will provide new insight into the role of mechanical forces in promoting injury in the intact emphysema lung, and the effect of mechanical forces on tissue remodeling. [unreadable] [unreadable]..
  12. Statistical Methods for Clinical Trials with Twin Births
    Michele Shaffer; Fiscal Year: 2007
    ..Thus, the effects of trial design and analysis need to be quantified and taken into consideration for studies that involve singletons and twin births. [unreadable] [unreadable] [unreadable] [unreadable]..
  13. Microbubbles: a novel treatment for hemorrhagic shock
    CLAS LUNDGREN; Fiscal Year: 2007
    ..The project is expected to bring the DDFPe treatment to a state of scientific underpinning and applicability in the animal model which lays a solid foundation for pursuing FDA approval for human use. ..
  14. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  15. Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled Trial
    Eduardo Bruera; Fiscal Year: 2009
    ..In this study, we will test if giving fluid through the vein will improve the symptoms, delay confusion and prolong life in patients who are no longer to drink at the end of life. ..
  16. Calpain mediated injury in post ischemic neurons
    ROBERT NEUMAR; Fiscal Year: 2008
    ..The results will provide fundamental insights into the mechanism of delayed post-ischemic neuronal necrosis, and facilitate the development of effective therapies for patients suffering from cardiac arrest and stroke. ..
  17. Pneumografting - a novel cell-based therapy for emphysema
    Edward P Ingenito; Fiscal Year: 2010
    ..We intend to advance this approach, known as pneumografting, into human trials under a physician-sponsored Investigation New Drug Application. ..
  18. Neonatal Resuscitation and Preterm Lung Injury
    Alan H Jobe; Fiscal Year: 2010
    ..This translational research should result in changes in resuscitation procedures for preterm infants. ..
  19. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..Relevance to Public Health: In this study, we will test if methadone is better than morphine in cancer pain control, quality of life, and is more cost-effective. ..
  20. Creation and demonstration of a palliative care research cooperative group
    Jean S Kutner; Fiscal Year: 2010
    ....
  21. O2 Sensing in Hypoxic Pulmonary Vasoconstriction
    Paul Schumacker; Fiscal Year: 2009
    ..Collectively, these studies will test whether a common O2 sensing mechanism functions in PA myocytes and endothelial cells to trigger their diverse responses in HPV. ..
  22. Prospective Investigation of Pulmonary Embolism Dx III
    JOHN WEG; Fiscal Year: 2008
    ..It is expected that 942 patients will be shown to have no PE or VTE. From among this group, 314 patients will be randomly selected for the index test, Gd-MRA/MRV. ..
  23. Modest supplemental oxygen worsens lung injury in a murine model of sepsis
    Neil Aggarwal; Fiscal Year: 2008
    ..This work has the potential to improve human outcomes and decrease burden on the health care system from this devastating illness. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
    ..abstract_text> ..
  25. The Predictive Value of Pre-plus Disease in ROP
    David Wallace; Fiscal Year: 2008
    ..abstract_text> ..
  26. CLINICAL RESEARCH CURRICULUM
    BRIAN STROM; Fiscal Year: 2004
    ..I. and co-PI s in the three distinct aspects of Clinical Research targeted by this program represent particular features of this proposal. ..
  27. DIFFERENTIAL VULNERABILITY TO MORBIDITIES OF SLEEP APNEA
    Sigrid Veasey; Fiscal Year: 2003
    ..Therefore, this work provides an essential foundation for determining gene function in the susceptibility of sleepiness, impaired cognation and behavioral responses caused by obstructive sleep apnea. (End of Abstract.) ..
  28. Parent Education on DNA Testing in the Newborn Screen
    Richard Parad; Fiscal Year: 2003
    ..On demand interactive in-hospital television education will provide a cost effective means for educating parents about genetics issues, implications of DNA based testing, and assessing their comprehension of the complex concepts. ..
  29. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  30. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  31. LUNG PHOSPHOLIPID APPEARANCE AND STABILITY
    Alan Jobe; Fiscal Year: 2002
    ....
  32. Pediatric Interstitial Lung Disease Conference
    Robin Deterding; Fiscal Year: 2004
    ..Communication between clinical and basic scientists and an enhanced interest in PILD will certainly occur. Ultimately the care of children with these rare diseases will be improved and the field advanced. ..
  33. NEONATAL TRAINING GRANT
    Alan Jobe; Fiscal Year: 2005
    ..The goal for this training grant is to support only research training for Neonatologists who have the potential and motivation to become successful research oriented academic neonatologists. ..
  34. Balancing Hope & Truth-Telling for Patients with Ca/COPD
    J Curtis; Fiscal Year: 2005
    ..These strategies will be described and translated into interventions targeting nurses, physicians, and teams who provide care for patients with cancer, COPD, and other life-limiting diseases. ..
  35. OXYGEN SENSING AND CELL SIGNALING IN HYPOXIA
    Paul Schumacker; Fiscal Year: 2001
    ..These studies will identify a novel pathway of cellular O2 detection, and may help clarify understanding of how cells adapt to lowered O2 conditions. ..
  36. NEW MEDIATORS OF CLINICAL LUNG MATURATION
    Alan Jobe; Fiscal Year: 2007
    ..A goal is to identify a mediator with potential for clinical use to induce lung maturation. ..
  37. O2 SENSING BY MITOCHONDRIA DURING INTERMITTENT HYPOXIA
    Paul Schumacker; Fiscal Year: 2003
    ..Collectively, these studies could identify a novel mechanism of O2 sensing in the lung, and provide a mechanistic explanation for the activation of gene transcritpion and cellular proliferation during intermittent hypoxia. ..
  38. NEUROCIRCULATORY RESPONSES IN OBSTRUCTIVE SLEEP APNEA
    VIRGINIA IMADOJEMU; Fiscal Year: 2003
    ..The PI has been funded by a Minority Supplement to Dr. Sinoway's R01 proposal from the NIH. This proposal will give the PI the additional support and training necessary to become an independent funded investigator. ..
  39. Responses to Surgical and Bronchoscopic Volume Reduction
    Edward Ingenito; Fiscal Year: 2006
    ..We believe that by accomplishing these objectives, we can help advance this technology into the clinical arena. ..
  40. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
  41. Training in Complementary and Alternative Medicine(CAM)
    Alfred Fishman; Fiscal Year: 2005
    ..Trainees will be candidates for a MS degree in Clinical Epidemiology. Contrary to a MPH degree, this program is similar to a PhD in its rigor. ..
  42. COGNITIVE EFFECTS OF LUNG VOLUME REDUCTION SURGERY
    Elizabeth Kozora; Fiscal Year: 2004
    ..Forty normal controls will be tested at baseline and 6-10 weeks follow- up. ..
  43. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2009
    ..Specific Aim 2. Determine the severity of CNS injury by in vivo &ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..
  44. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
    ..This research will use clinically relevant prenatal exposures and postnatal sensitization to establish under controlled conditions any link between antenatal inflammation and the hygiene hypothesis. [unreadable] [unreadable] [unreadable]..
  45. Methylphenidate for Fatigue in Advanced Cancer Patients
    Eduardo Bruera; Fiscal Year: 2009
    ....
  46. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  47. GERIATRIC CLINICAL EPIDEMIOLOGY TRAINING GRANT
    STEVEN HALBERT; Fiscal Year: 2007
    ..g., clinical trials, case control, cohort research, etc.), and the faculties' commitment to collaborative research. [unreadable] [unreadable]..
  48. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    JOHN WEG; Fiscal Year: 2003
    ..of lives lost from underdiagnosis, and major bleeding from overdiagnosis; 2) the potential applicability of a OF A NEW TECHNOLOGY FOR THE DIAGNOSIS OF PE THAT WILL HAVE WIDESPREAD AVAILABILITY; AND 3) THE INVESTIGATION ..
  49. Improving Physician Skill at Providing End-of-Life Care
    J Curtis; Fiscal Year: 2004
    ..The results will allow investigators and others to develop targeted educational and systemic interventions to improve the quality of this care. ..
  50. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2002
    ..abstract_text> ..
  51. C1q-complement and hypoxic-ischemic injury in the developing brain.
    Vadim S Ten; Fiscal Year: 2010
    ....
  52. MOLECULAR NEUROIMAGING OF AIDS DEMENTIA--ANIMAL MODELS
    Ramon Gonzalez; Fiscal Year: 2002
    ..The relationship of viral infection in the brain to metabolic and pathological abnormalities subsequently observed will be determined. ..
  53. PATHOPHYSIOLOGY OF EXERCISE INDUCED ASTHMA
    EDWARD MCFADDEN; Fiscal Year: 2003
    ..abstract_text> ..
  54. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  55. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  56. Genetic Modifiers in CF: Role of ABH polymorphisms
    JENNIFER TAYLOR COUSAR; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  58. Neuropsychological Testing for Lupus and Depression
    Elizabeth Kozora; Fiscal Year: 2002
    ....
  59. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. ADVANCED MR SPECTROSCOPY OF SIV BRAIN INJURY
    Ramon Gonzalez; Fiscal Year: 2001
    ..In other experiments, the animals will be treated after infection. These studies have been simplified since the prior submission. They will begin on Year 02 of the grant. ..
  61. MRI and MRS Correlates of Cognitive Function in SLE
    Elizabeth Kozora; Fiscal Year: 2007
    ..This will better prepare clinicians with clear diagnostic avenues and better treatment options in the future. [unreadable] [unreadable]..