extracorporeal membrane oxygenation

Summary

Summary: Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.

Top Publications

  1. ncbi Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial
    Giles J Peek
    Department of Cardiothoracic Surgery, Glenfield Hospital, Leicester, UK
    Lancet 374:1351-63. 2009
  2. ncbi Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database
    Thomas V Brogan
    Division of Critical Care Medicine, Department of Pediatrics, Seattle Children s Hospital, University of Washington School of Medicine, Seattle, WA, USA
    Intensive Care Med 35:2105-14. 2009
  3. ncbi Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1)
    Moronke A Noah
    Heartlink ECMO Centre, Glenfield Hospital, Leicester, England
    JAMA 306:1659-68. 2011
  4. ncbi Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal
    Pier Paolo Terragni
    Dipartimento di Anestesiologia e Medicina degli Stati Critici, Universita di Torino, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, Turin, Italy
    Anesthesiology 111:826-35. 2009
  5. ncbi Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era
    Graeme Maclaren
    Cardiothoracic ICU, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore
    Intensive Care Med 38:210-20. 2012
  6. ncbi Using extracorporeal life support to resuscitate adult postcardiotomy cardiogenic shock: treatment strategies and predictors of short-term and midterm survival
    Meng Yu Wu
    Department of Cardiovascular Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Resuscitation 81:1111-6. 2010
  7. pmc Morbidity and mortality in late preterm infants with severe hypoxic respiratory failure on extra-corporeal membrane oxygenation
    Ashwin Ramachandrappa
    Department of Pediatrics, Division of Neonatology, Emory University, Atlanta, GA 30322, USA
    J Pediatr 159:192-8.e3. 2011
  8. ncbi Extracorporeal membrane oxygenation for postcardiotomy mechanical cardiovascular support in children with congenital heart disease
    Joshua W Salvin
    Cardiac Intensive Care Unit, Department of Cardiology, Children s Hospital Boston, MA 02115, USA
    Paediatr Anaesth 18:1157-62. 2008
  9. pmc Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet
    Ashish R Kurundkar
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Pediatr Res 68:128-33. 2010
  10. ncbi Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis
    Tai Pham
    Service de Reanimation Medicale, Groupe Hospitalier Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Respir Crit Care Med 187:276-85. 2013

Research Grants

  1. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
  2. Attenuation of Ischemia-Reperfusion Injury in Limb Auto- and Allografts
    GEOFFROY COURCELLE SISK; Fiscal Year: 2013
  3. Phase II Trial of Sildenafil in Newborns with Persistent Pulmonary Hyptertension
    Robin H Steinhorn; Fiscal Year: 2010
  4. A point-of-care device for generating nitric oxide for inhalation
    Robert L Whalen; Fiscal Year: 2011
  5. Kidney Injury and Dysfunction Support (KIDS)
    Matthew Paden; Fiscal Year: 2010
  6. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2013
  7. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
  8. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2011
  9. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2012
  10. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2013

Detail Information

Publications353 found, 100 shown here

  1. ncbi Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial
    Giles J Peek
    Department of Cardiothoracic Surgery, Glenfield Hospital, Leicester, UK
    Lancet 374:1351-63. 2009
    ..We aimed to delineate the safety, clinical efficacy, and cost-effectiveness of extracorporeal membrane oxygenation (ECMO) compared with conventional ventilation support.
  2. ncbi Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database
    Thomas V Brogan
    Division of Critical Care Medicine, Department of Pediatrics, Seattle Children s Hospital, University of Washington School of Medicine, Seattle, WA, USA
    Intensive Care Med 35:2105-14. 2009
    To evaluate clinical and treatment factors for patients recorded in the Extracorporeal Life Support Organization (ELSO) registry and survival of adult extracorporeal membrane oxygenation (ECMO) respiratory failure patients.
  3. ncbi Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1)
    Moronke A Noah
    Heartlink ECMO Centre, Glenfield Hospital, Leicester, England
    JAMA 306:1659-68. 2011
    b>Extracorporeal membrane oxygenation (ECMO) can support gas exchange in patients with severe acute respiratory distress syndrome (ARDS), but its role has remained controversial...
  4. ncbi Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal
    Pier Paolo Terragni
    Dipartimento di Anestesiologia e Medicina degli Stati Critici, Universita di Torino, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, Turin, Italy
    Anesthesiology 111:826-35. 2009
    ..The authors verified whether VT lower than 6 ml/kg may enhance lung protection and that consequent respiratory acidosis may be managed by extracorporeal carbon dioxide removal...
  5. ncbi Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era
    Graeme Maclaren
    Cardiothoracic ICU, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore
    Intensive Care Med 38:210-20. 2012
    b>Extracorporeal membrane oxygenation (ECMO) has been used in clinical medicine for 40 years but remains controversial therapy, particularly in adult patients with severe respiratory failure...
  6. ncbi Using extracorporeal life support to resuscitate adult postcardiotomy cardiogenic shock: treatment strategies and predictors of short-term and midterm survival
    Meng Yu Wu
    Department of Cardiovascular Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Resuscitation 81:1111-6. 2010
    ..Postcardiotomy extracorporeal life support (ECLS) is a resource-demanding therapy with varied results among institutions. An organized protocol was necessary to improve the effectiveness of this therapy...
  7. pmc Morbidity and mortality in late preterm infants with severe hypoxic respiratory failure on extra-corporeal membrane oxygenation
    Ashwin Ramachandrappa
    Department of Pediatrics, Division of Neonatology, Emory University, Atlanta, GA 30322, USA
    J Pediatr 159:192-8.e3. 2011
    ..To evaluate morbidity, mortality, and associated risk factors in late preterm term infants (34-0/7 to 36-6/7 weeks) requiring extra-corporeal membrane oxygenation (ECMO)...
  8. ncbi Extracorporeal membrane oxygenation for postcardiotomy mechanical cardiovascular support in children with congenital heart disease
    Joshua W Salvin
    Cardiac Intensive Care Unit, Department of Cardiology, Children s Hospital Boston, MA 02115, USA
    Paediatr Anaesth 18:1157-62. 2008
    b>Extracorporeal membrane oxygenation (ECMO) is increasingly used to support postcardiotomy cardiorespiratory failure in children with congenital heart disease...
  9. pmc Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet
    Ashish R Kurundkar
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Pediatr Res 68:128-33. 2010
    b>Extracorporeal membrane oxygenation (ECMO) is an important life-support system used in neonates and young children with intractable cardiorespiratory failure...
  10. ncbi Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis
    Tai Pham
    Service de Reanimation Medicale, Groupe Hospitalier Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Respir Crit Care Med 187:276-85. 2013
    Many patients with severe acute respiratory distress syndrome (ARDS) caused by influenza A(H1N1) infection receive extracorporeal membrane oxygenation (ECMO) as a rescue therapy.
  11. ncbi Extracorporeal membrane oxygenation in severe trauma patients with bleeding shock
    Matthias Arlt
    Department of Anesthesiology, University Hospital Regensburg, Regensburg, Germany
    Resuscitation 81:804-9. 2010
    ..b>Extracorporeal membrane oxygenation (ECMO) can be effective in severe cardiopulmonary failure, but preexisting bleeding is still a ..
  12. ncbi Outcome of patients with profound cardiogenic shock after cardiopulmonary resuscitation and prompt extracorporeal membrane oxygenation support. A single-center observational study
    Sheng Ying Chung
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Circ J 76:1385-92. 2012
    The in-hospital outcome of patients with profound cardiogenic shock (CS) undergoing extracorporeal membrane oxygenation (ECMO) and prognostic predictors were analyzed.
  13. ncbi Ambulatory veno-venous extracorporeal membrane oxygenation: innovation and pitfalls
    Jose P Garcia
    Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Thorac Cardiovasc Surg 142:755-61. 2011
    ..Veno-venous extracorporeal membrane oxygenation is an available treatment option for these patients but, in its conventional form, can be ..
  14. ncbi Prognosis of patients on extracorporeal membrane oxygenation: the impact of acute kidney injury on mortality
    Yung Chang Chen
    Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Ann Thorac Surg 91:137-42. 2011
    b>Extracorporeal membrane oxygenation (ECMO) has been utilized for patients in critical condition, such as those with life-threatening respiratory failure or postcardiotomy cardiogenic shock...
  15. pmc Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support
    Enno D Wildschut
    Intensive Care and Department of Paediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 5:e10938. 2010
    To evaluate the effect of extracorporeal membrane oxygenation (ECMO) support on pharmacokinetics of oseltamivir and oseltamivir carboxylate (OC) in children.
  16. ncbi Review of ECMO (extra corporeal membrane oxygenation) support in critically ill adult patients
    Silvana F Marasco
    Cardiothoracic Department, Epworth Hospital, Richmond, Australia
    Heart Lung Circ 17:S41-7. 2008
    ..In this review, the technical aspects of ECMO cannulation, maintenance and weaning are outlined. Complication rates and outcomes are reviewed and our experience at The Epworth Hospital is summarized...
  17. ncbi Extracorporeal membrane oxygenation for ARDS in adults
    Daniel Brodie
    Columbia University College of Physicians and Surgeons, and New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 365:1905-14. 2011
    ..She is placed in the prone position and a neuromuscular blocking agent is administered, without improvement in her Pao2. An intensive care specialist recommends the initiation of extracorporeal membrane oxygenation (ECMO).
  18. ncbi Severe hypoxemic respiratory failure: part 2--nonventilatory strategies
    Suhail Raoof
    Division of Pulmonary and Critical Care Medicine, New York Methodist Hospital, 506 Sixth St, Brooklyn, NY 11215, USA
    Chest 137:1437-48. 2010
    ..These interventions may be considered for use, particularly for cases of refractory severe hypoxemia, with proper appreciation of potential costs and adverse effects...
  19. ncbi Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Crit Care Med 36:1404-11. 2008
    To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock.
  20. ncbi Pharmacokinetic changes during extracorporeal membrane oxygenation: implications for drug therapy of neonates
    Marcia L Buck
    Children s Medical Center and Schools of Medicine and Nursing, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Clin Pharmacokinet 42:403-17. 2003
    b>Extracorporeal membrane oxygenation (ECMO) is a prolonged form of cardiopulmonary bypass used to support patients with life-threatening respiratory or cardiac failure...
  21. ncbi Extracorporeal membrane oxygenation support for adult postcardiotomy cardiogenic shock
    Wen Je Ko
    Department of Surgery, National Taiwan University Hospital, Taipei
    Ann Thorac Surg 73:538-45. 2002
    ..We report our experience using extracorporeal membrane oxygenation (ECMO) in adult patients with postcardiotomy cardiogenic shock, and analyze the factors that ..
  22. ncbi Cerebral outcome in adult patients treated with extracorporeal membrane oxygenation
    Ivar Risnes
    Department of Thoracic and Cardiovascular Surgery, Rikshospitalet University Hospital, Oslo, Norway
    Ann Thorac Surg 81:1401-6. 2006
    b>Extracorporeal membrane oxygenation (ECMO) carries a high risk of brain injury. The aim of this study was to determine the cerebral status in 28 adult survivors on average 5.0 (range, 0...
  23. ncbi Extracorporeal membrane oxygenation as a bridge to lung transplant: midterm outcomes
    Christian A Bermudez
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Thorac Surg 92:1226-31; discussion 1231-2. 2011
    b>Extracorporeal membrane oxygenation (ECMO) is used occasionally as a bridge to lung transplantation. The impact on mid-term survival is unknown...
  24. ncbi Extracorporeal membrane oxygenation, an anesthesiologist's perspective: physiology and principles. Part 1
    Sandeep Chauhan
    Department of Cardiac Anesthesia, C N C, All India Institute of Medical Sciences, New Delhi, India
    Ann Card Anaesth 14:218-29. 2011
    b>Extracorporeal membrane oxygenation (ECMO) is an adaptation of conventional cardiopulmonary bypass techniques to provide cardiopulmonary support...
  25. ncbi Hemolysis during cardiac extracorporeal membrane oxygenation: a case-control comparison of roller pumps and centrifugal pumps in a pediatric population
    Jonathan Byrnes
    Department of Pediatrics Section of Critical Care, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA
    ASAIO J 57:456-61. 2011
    b>Extracorporeal membrane oxygenation (ECMO) is a lifesaving therapy, which has been used for the support of children with a broad range of diseases...
  26. ncbi Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
    Andrew Davies
    FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    JAMA 302:1888-95. 2009
    ..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO).
  27. ncbi Extracorporeal membrane oxygenation in adult acute respiratory distress syndrome
    Pauline K Park
    Division of Acute Care Surgery, Department of Surgery, University of Michigan Health System, 1500 East Medical Center Drive, 1C340A UH, SPC 5033, Ann Arbor, MI 48109 5033, USA
    Crit Care Clin 27:627-46. 2011
    The role of extracorporeal membrane oxygenation (ECMO) in supporting adult refractory respiratory failure continues to evolve...
  28. ncbi Initial experience with CentriMag extracorporal membrane oxygenation for support of critically ill patients with refractory cardiogenic shock
    Tariq A Aziz
    Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Heart Lung Transplant 29:66-71. 2010
    ..Outcomes of the first 10 patients to receive this device at our institutions are presented...
  29. ncbi The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks
    Nicolo Patroniti
    Department of Experimental Medicine, University of Milan Bicocca, Via Pergolesi 33, 20052 Monza, Italy
    Intensive Care Med 37:1447-57. 2011
    ..network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS)...
  30. pmc Myocardial oxidative metabolism and protein synthesis during mechanical circulatory support by extracorporeal membrane oxygenation
    Colleen M O Kelly Priddy
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Am J Physiol Heart Circ Physiol 304:H406-14. 2013
    b>Extracorporeal membrane oxygenation (ECMO) provides essential mechanical circulatory support necessary for survival in infants and children with acute cardiac decompensation...
  31. pmc Extracorporeal membrane oxygenation with spontaneous breathing as a bridge to lung transplantation
    Mario Nosotti
    Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    Interact Cardiovasc Thorac Surg 16:55-9. 2013
    A large number of transplantation centres consider extracorporeal membrane oxygenation as an inappropriate option for bridging critical patients to lung transplantation...
  32. pmc First-year experience of a Brazilian tertiary medical center in supporting severely ill patients using extracorporeal membrane oxygenation
    Marcelo Park
    Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo SP, Brazil
    Clinics (Sao Paulo) 67:1157-63. 2012
    The aim of this manuscript is to describe the first year of our experience using extracorporeal membrane oxygenation support.
  33. ncbi Extracorporeal membrane oxygenation in burn and smoke inhalation injury
    Sven Asmussen
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX 77555, USA
    Burns 39:429-35. 2013
    A systematic review and meta-analysis was conducted to assess the level of evidence for the use of extracorporeal membrane oxygenation (ECMO) in hypoxemic respiratory failure resulting from burn and smoke inhalation injury...
  34. pmc The effect of venovenous extra-corporeal membrane oxygenation (ECMO) therapy on immune inflammatory response of cerebral tissues in porcine model
    Qiyi Chen
    Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China
    J Cardiothorac Surg 8:186. 2013
    ..The aim of this study is to investigate the effect of VV- ECMO on immune inflammatory response of cerebral tissues and neurological impairment...
  35. ncbi Veno-arterial extracorporeal membrane oxygenation using Levitronix centrifugal pump as bridge to decision for refractory cardiogenic shock
    Claudio F Russo
    A De Gasperis Cardiology and Cardiac Surgery Department, Niguarda Ca Granda Hospital, Milan, Italy
    J Thorac Cardiovasc Surg 140:1416-21. 2010
    Cardiogenic shock still carries a very high mortality. We adopted veno-arterial extracorporeal membrane oxygenation using the Levitronix centrifugal pump (Levitronix LLC, Waltham, Massachusetts) as a first-line treatment of cardiogenic ..
  36. ncbi Should we emergently revascularize occluded coronaries for cardiac arrest?: rapid-response extracorporeal membrane oxygenation and intra-arrest percutaneous coronary intervention
    Eisuke Kagawa
    Department of Cardiology, Hiroshima City Asa Hospital, 2 1 1, Kabeminami, Asakita ku, Hiroshima, 731 0293 Japan
    Circulation 126:1605-13. 2012
    b>Extracorporeal membrane oxygenation (ECMO) and percutaneous coronary intervention (PCI) may be useful in cardiopulmonary resuscitation. However, little is known about the combination of ECMO and intra-arrest PCI...
  37. ncbi Venovenous extracorporeal membrane oxygenation for acute lung failure in adults
    Christof Schmid
    Department of Cardiothoracic Surgery, University Medical Center, Regensburg, Germany
    J Heart Lung Transplant 31:9-15. 2012
    Acute lung failure (ALF) is an increasing problem that can be treated with venovenous extracorporeal membrane oxygenation (vv-ECMO). This report summarizes prospectively collected data of an institutional experience with vv-ECMO.
  38. ncbi Primary lung transplantation after bridge with extracorporeal membrane oxygenation: a plea for a shift in our paradigms for indications
    Gyorgy Lang
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Transplantation 93:729-36. 2012
    The introduction of the lung allocation score has brought lung transplantation (LTX) of patients on extracorporeal membrane oxygenation (ECMO) bridge into the focus of interest...
  39. ncbi Extracorporeal membrane oxygenation in severe hypoxemia: time for reappraisal?
    Luciano Cesar Pontes Azevedo
    Hospital Sirio Libanes, São Paulo SP Brasil
    J Bras Pneumol 38:7-12. 2012
    ..Many of those cases were treated with extracorporeal membrane oxygenation (ECMO), which renewed international interest in the technique...
  40. ncbi Efficacy of veno-arterial extracorporeal membrane oxygenation in acute myocardial infarction with cardiogenic shock
    Hyungtae Kim
    Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Republic of Korea
    Resuscitation 83:971-5. 2012
    We analyzed the results of acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) necessitating extracorporeal membrane oxygenation (ECMO), and investigated for the associated risk factors for poor clinical outcomes.
  41. ncbi Continuous renal replacement therapy (CRRT) attenuates myocardial inflammation and mitochondrial injury induced by venovenous extracorporeal membrane oxygenation (VV ECMO) in a healthy piglet model
    Juanhong Shen
    Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China
    Inflammation 36:1186-93. 2013
    ..study, we investigated the myocardial inflammation and mitochondrial function during venovenous extracorporeal membrane oxygenation (VV ECMO) and further evaluated the effects of continuous renal replacement therapy (CRRT) on them...
  42. ncbi Extracorporeal membrane oxygenation for respiratory failure in adults
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Curr Opin Crit Care 18:99-104. 2012
    This article reviews case series and trials that evaluated extracorporeal membrane oxygenation (ECMO) for respiratory failure and describes patient and circuit management in the modern era of ECMO support.
  43. pmc Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation
    Melania M Bembea
    Department of Anesthesiology and Critical Care, Johns Hopkins University, Baltimore, MD, USA mbembea1jhmi edu
    Pediatr Crit Care Med 12:572-9. 2011
    To determine whether, in children, plasma glial fibrillary acidic protein is associated with brain injury during extracorporeal membrane oxygenation and with mortality.
  44. ncbi Extracorporeal Life Support Organization Registry Report 2012
    Matthew L Paden
    Division of Critical Care, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA
    ASAIO J 59:202-10. 2013
    ..Use of ECLS for cardiac support represents a large area of consistent growth. Approximately 13,000 patients have been treated with survival to discharge rates of 40%, 49%, and 39% for neonates, pediatric, and adults, respectively...
  45. pmc Cerebral and peripheral tissue oxygenation in children supported on ECMO for cardio-respiratory failure
    Maria D Papademetriou
    Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
    Adv Exp Med Biol 662:447-53. 2010
    b>Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for patients with cardio-respiratory failure. Establishing, maintaining and weaning from ECMO may increase the risk for intracranial injury...
  46. ncbi Increased extracorporeal membrane oxygenation center case volume is associated with improved extracorporeal membrane oxygenation survival among pediatric patients
    Tara Karamlou
    Division of Pediatric Cardiac Surgery, University of California, San Francisco, CA, USA
    J Thorac Cardiovasc Surg 145:470-5. 2013
    We sought to examine the relationship between extracorporeal membrane oxygenation center case volume and survival in pediatric patients requiring extracorporeal membrane oxygenation support.
  47. pmc Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn
    G Ganesh Konduri
    Department of Pediatrics, Division of Neonatology, Children s Research Institute and Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 56:579-600, Table of Contents. 2009
    ..This review focuses on the diagnosis, recent advances in management, and recommendations for the long-term follow-up of infants who have PPHN...
  48. ncbi Favourable survival of in-hospital compared to out-of-hospital refractory cardiac arrest patients treated with extracorporeal membrane oxygenation: an Italian tertiary care centre experience
    Leonello Avalli
    Servizio di Anestesia e Rianimazione 1, U O S Anestesia e Terapia intensiva CCH, Universita Milano Bicocca, Ospedale S Gerardo, Via Pergolesi 33, 20052 Monza, Italy
    Resuscitation 83:579-83. 2012
    b>Extracorporeal membrane oxygenation (ECMO) support has been suggested to improve the survival rate in patients with refractory in- and out-of-hospital cardiac arrest (IHCA and OHCA)...
  49. ncbi Neonatal ECMO: neuroimaging and neurodevelopmental outcome
    Dorothy Bulas
    Division of Diagnostic Imaging, Children s National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA
    Semin Perinatol 29:58-65. 2005
    Intracranial injury continues to be a major complication associated with extracorporeal membrane oxygenation (ECMO)-treated neonates...
  50. pmc Children with fulminant myocarditis rescued with extracorporeal membrane oxygenation
    E T Wu
    Heart 92:1325-6. 2006
  51. ncbi Early extracorporeal life support as rescue for Wegener granulomatosis with diffuse alveolar hemorrhage and acute respiratory distress syndrome: a case report and literature review
    Mark Joseph
    Division of Trauma and Critical Care Surgery, Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7228, USA
    Pediatr Emerg Care 27:1163-6. 2011
    ..The study's objective was to report a case and review the literature on the use of extracorporeal life support in the face of severe pulmonary hemorrhage for acute respiratory distress syndrome...
  52. ncbi Current status of extracorporeal life support (ECMO) for cardiopulmonary failure
    R H Bartlett
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Minerva Anestesiol 76:534-40. 2010
    ..life support with artificial heart and lung for cardiopulmonary failure is commonly called extracorporeal membrane oxygenation (ECMO)...
  53. ncbi Prolonged extracorporeal membrane oxygenation-assisted support provides improved survival in hypothermic patients with cardiocirculatory arrest
    Elfriede Ruttmann
    Department of Cardiac Surgery, Innsbruck Medical University, Tyrol, Austria
    J Thorac Cardiovasc Surg 134:594-600. 2007
    ..gold standard in the treatment of hypothermic cardiocirculatory arrest; however, few centers use extracorporeal membrane oxygenation instead of standard extracorporeal circulation for this indication...
  54. ncbi Kidney transplantation from organ donors following cardiopulmonary death using extracorporeal membrane oxygenation support
    Mark T Gravel
    University of Michigan Health System, Ann Arbor, Michigan, USA
    Ann Transplant 9:57-8. 2004
    b>Extracorporeal membrane oxygenation (ECMO) has the ability to provide normal organ perfusion and oxygenation in the absence of cardiac function and thus has the potential to improve viability of subsequently transplanted kidneys...
  55. ncbi Use of extracorporeal membrane oxygenation in a patient with diffuse alveolar hemorrhage
    S Hinan Ahmed
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 126:305-9. 2004
    b>Extracorporeal membrane oxygenation (ECMO) was developed as a supportive therapy for severe respiratory failure...
  56. ncbi Increased sedation requirements in patients receiving extracorporeal membrane oxygenation for respiratory and cardiorespiratory failure
    K Shekar
    Critical Care Research Group, Adult Intensive Care Unit, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Anaesth Intensive Care 40:648-55. 2012
    Critically ill patients receiving extracorporeal membrane oxygenation (ECMO) are often noted to have increased sedation requirements. However, data related to sedation in this complex group of patients is limited...
  57. ncbi Normothermic kidney preservation
    Sarah A Hosgood
    Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Leicester, UK
    Curr Opin Organ Transplant 16:169-73. 2011
    ..Normothermic preservation can be adapted to improve the quality of kidneys for transplantation by a variety of techniques...
  58. pmc Use of nafamostat mesilate as an anticoagulant during extracorporeal membrane oxygenation
    Sang Jin Han
    Division of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
    J Korean Med Sci 26:945-50. 2011
    ..Nafamostat mesilate should be considered as an alternative anticoagulant to heparin to reduce bleeding complications during ECMO...
  59. ncbi Initial experience with single cannulation for venovenous extracorporeal oxygenation in adults
    Christian A Bermudez
    Heart, Lung, and Esophageal Surgery Institute, Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 90:991-5. 2010
    Historically, venovenous extracorporeal membrane oxygenation has required dual cannulation. A single-venous cannulation strategy may facilitate implantation and patient mobilization...
  60. pmc Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation
    Maurice J Ahsman
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, Netherlands
    Antimicrob Agents Chemother 54:1734-41. 2010
    b>Extracorporeal membrane oxygenation (ECMO) is used to temporarily sustain cardiac and respiratory function in critically ill infants but can cause pharmacokinetic changes necessitating dose modifications...
  61. ncbi Extracorporeal membrane oxygenation support improves survival of patients with severe Hantavirus cardiopulmonary syndrome
    Charles A Dietl
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    J Thorac Cardiovasc Surg 135:579-84. 2008
    The purposes of this study are to evaluate the outcome of extracorporeal membrane oxygenation support in a subgroup of patients with Hantavirus cardiopulmonary syndrome who had a predicted mortality of 100% and to assess the ..
  62. ncbi Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 139:302-11, 311.e1. 2010
    ..5% to 1.5% of cases. Risk factors influencing early or long-term outcome after extracorporeal membrane oxygenation implantation are not well described.
  63. ncbi Venoarterial extracorporeal membrane oxygenation for treatment of cardiogenic shock: clinical experiences in 45 adult patients
    Farhad Bakhtiary
    Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt Main, Germany
    J Thorac Cardiovasc Surg 135:382-8. 2008
    Venoarterial extracorporeal membrane oxygenation is an established treatment option in patients with cardiogenic shock...
  64. ncbi Use of venovenous extracorporeal membrane oxygenation and an atrial septostomy for pulmonary and right ventricular failure
    Daniele Camboni
    Extracorporeal Life Support Laboratory, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 91:144-9. 2011
    ..This study was designed to evaluate the effectiveness of an atrial septostomy with venovenous extracorporeal membrane oxygenation (VV-ECMO) as a novel potential bridge to transplantation.
  65. ncbi Use of bicaval dual-lumen catheter for adult venovenous extracorporeal membrane oxygenation
    Jeffrey Javidfar
    Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    Ann Thorac Surg 91:1763-8; discussion 1769. 2011
    b>Extracorporeal membrane oxygenation (ECMO) provides supplementary oxygenation and carbon dioxide removal for selected patients on mechanical ventilatory support...
  66. ncbi Extracorporeal membrane oxygenation for pediatric respiratory failure: Survival and predictors of mortality
    Luke A Zabrocki
    Division of Pediatric Critical Care, Department of Pediatrics, Primary Children s Medical Center, University of Utah, Salt Lake City, UT, USA
    Crit Care Med 39:364-70. 2011
    The last multicentered analysis of extracorporeal membrane oxygenation in pediatric acute respiratory failure was completed in 1993. We reviewed recent international data to evaluate survival and predictors of mortality.
  67. ncbi Anticoagulation and coagulation management for ECMO
    William C Oliver
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Cardiothorac Vasc Anesth 13:154-75. 2009
    Advances in extracorporeal membrane oxygenation (ECMO) management have helped to reduce complications compared with its inception but they remain high. The principal causes of mortality and morbidity are bleeding and thrombosis...
  68. ncbi Extracorporeal membrane oxygenation (ECMO) reconsidered
    John L Moran
    Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    Crit Care Resusc 12:131-5. 2010
    The role of extracorporeal membrane oxygenation (ECMO) in the treatment of the acute respiratory distress syndrome (ARDS) is controversial, notwithstanding the recent publication of the results of the CESAR (Conventional Ventilation or ..
  69. pmc A systematic review to inform institutional decisions about the use of extracorporeal membrane oxygenation during the H1N1 influenza pandemic
    Matthew D Mitchell
    Center for Evidence Based Practice, University of Pennsylvania Health System, Philadelphia, PA, USA
    Crit Care Med 38:1398-404. 2010
    To systematically evaluate the effect of extracorporeal membrane oxygenation on survival in adults with acute respiratory failure and to help inform institutional decisions about implementing an extracorporeal membrane oxygenation ..
  70. ncbi Temporary extracorporeal membrane oxygenation in the treatment of acute traumatic lung injury
    W Voelckel
    Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria
    Can J Anaesth 45:1097-102. 1998
    ..To report two cases of acute life-threatening traumatic lung injury, who required temporary extracorporeal veno-venous membrane oxygenation (ECMO), and airlifting to a level I trauma centre...
  71. ncbi Fulminant peripartum cardiomyopathy rescue with extracorporeal membranous oxygenation
    I J Smith
    Department of Cardiothoracic, Auckland City Hospital, Grafton, Auckland, New Zealand
    Int J Obstet Anesth 18:186-8. 2009
    ..This case highlights the potential of this lifesaving treatment, in appropriately selected patients, where death seems inevitable. No major complications of extracorporeal membranous oxygenation occurred in this patient...
  72. ncbi Acute kidney injury in adult postcardiotomy patients with extracorporeal membrane oxygenation: evaluation of the RIFLE classification and the Acute Kidney Injury Network criteria
    Xiaolei Yan
    Intensive Care Unit, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, PR China
    Eur J Cardiothorac Surg 37:334-8. 2010
    Acute kidney injury (AKI) is one of the major complications in adult postcardiotomy patients on extracorporeal membrane oxygenation (ECMO) support...
  73. ncbi Cytokine imbalance in infants receiving extracorporeal membrane oxygenation for respiratory failure
    Reinout J Mildner
    Heartlink ECMO Centre, Glenfield Hospital, Leicester, UK
    Biol Neonate 88:321-7. 2005
    It is likely that the imbalance between the pro- and anti-inflammatory cytokines will determine the outcome in infants with severe respiratory failure receiving extracorporeal membrane oxygenation (ECMO).
  74. pmc Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine
    R Britt McILwain
    University Hospital Services, University of Alabama at Birmingham UAB, Birmingham, AL 35294, USA
    Lab Invest 90:128-39. 2010
    b>Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure...
  75. ncbi Congenital diaphragmatic hernia: current status and review of the literature
    Anthony S De Buys Roessingh
    Service de Chirurgie Pediatrique, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011, Lausanne, Switzerland
    Eur J Pediatr 168:393-406. 2009
    ..The benefits of other drugs or technical improvements such as the use of inhaled nitric oxide or extracorporeal membrane oxygenation (ECMO) are still being debated and no single strategy is accepted worldwide...
  76. ncbi Extracorporeal support for organ donation after cardiac death effectively expands the donor pool
    Joseph F Magliocca
    Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
    J Trauma 58:1095-101; discussion 1101-2. 2005
    ..Study parameters included increase in number of donors and organs, types of organs procured, and viability of kidneys transplanted...
  77. ncbi The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity
    M G Peetsold
    Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
    Pediatr Surg Int 25:1-17. 2009
    ..Based on such studies a more focused approach for routine follow-up programs may be established...
  78. ncbi Preliminary result of an algorithm to select proper ventricular assist devices for high-risk patients with extracorporeal membrane oxygenation support
    Y S Chen
    Department of Cardiothoracic Surgery, National Taiwan University Hospital, Taipei, Taiwan
    J Heart Lung Transplant 20:850-7. 2001
    b>Extracorporeal membrane oxygenation (ECMO) is not suitable for long-term support because of its high incidence of complications...
  79. ncbi Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation
    Yves Fromes
    Department of Cardiac Surgery, Fondation Hopital Saint Joseph, 185 rue Raymond Losserand, Paris, France
    Eur J Cardiothorac Surg 22:527-33. 2002
    ..A novel technique based on a minimal extracorporeal circulation (MECC(R)) system has been evaluated with regard to the inflammatory response in a prospective study involving patients undergoing coronary artery bypass grafting...
  80. pmc Extracorporeal life support for severe acute respiratory distress syndrome in adults
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    Ann Surg 240:595-605; discussion 605-7. 2004
    ..The objective of this study was to evaluate our experience with ECLS in adult patients with severe ARDS with respect to mortality and morbidity...
  81. ncbi Extracorporeal membrane oxygenation for refractory cardiogenic shock after cardiac surgery: predictors of early mortality and outcome from 51 adult patients
    Po Shun Hsu
    Division of Cardiovascular Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Eur J Cardiothorac Surg 37:328-33. 2010
    b>Extracorporeal membrane oxygenation (ECMO) offers temporary haemodynamic support for those with refractory cardiogenic shock after cardiac surgery...
  82. ncbi Early and intermediate results of rescue extracorporeal membrane oxygenation in adult cardiogenic shock
    Jiangang Wang
    Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, Peoples Republic of China
    Ann Thorac Surg 88:1897-903. 2009
    We retrospectively evaluated the early and intermediate results of use of temporary extracorporeal membrane oxygenation (ECMO) support and examined its effect on quality of life (QOL).
  83. ncbi Extracorporeal Life Support Registry Report 2008: neonatal and pediatric cardiac cases
    Nikkole M Haines
    Pediatric Cardiac Research Laboratory, Department of Pediatrics, Penn State Milton S Hershey Medical Center, Penn State College Medicine, Penn State Hershey Children s Hospital, Hershey, Pennsylvania 17033 0850, USA
    ASAIO J 55:111-6. 2009
    ..The major mechanical complications facing cardiac ECLS patients are oxygenator failure and clots in the circuit. Databases such as this one provide powerful tools for institutions, clinicians, and researchers...
  84. ncbi Extracorporeal membrane oxygenation for pandemic H1N1 2009 respiratory failure
    B Holzgraefe
    Section for Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Paediatric Anaesthesia and Intensive Care, ECMO Center Karolinska, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden
    Minerva Anestesiol 76:1043-51. 2010
    ..If, in spite of maximal conventional critical care, the patient's condition deteriorates, extracorporeal membrane oxygenation (ECMO) may be a life-saving procedure.
  85. ncbi Extracorporeal membrane oxygenation for the support of infants, children, and young adults with acute myocarditis: a review of the Extracorporeal Life Support Organization registry
    Satish K Rajagopal
    Department of Cardiology, Children s Hospital Boston, Boston, MA, USA
    Crit Care Med 38:382-7. 2010
    To describe survival outcomes for pediatric patients supported with extracorporeal membrane oxygenation for severe myocarditis and identify risk factors for in-hospital mortality.
  86. ncbi Successful use of bivalirudin as anticoagulant for ECMO in a patient with acute HIT
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 83:1865-7. 2007
    ..of an acute type A aortic dissection had acute heparin-induced thrombocytopenia develop during extracorporeal membrane oxygenation. Heparin was discontinued and the anticoagulant was switched to the direct thrombin inhibitor ..
  87. ncbi Traumatic lung injury treated by extracorporeal membrane oxygenation (ECMO)
    J A Cordell-Smith
    Heartlink ECMO Centre, The Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Injury 37:29-32. 2006
    ..b>Extracorporeal membrane oxygenation (ECMO) has been used successfully in critically ill adult trauma patients and can offer an ..
  88. ncbi In vitro evaluation of sedative drug losses during extracorporeal membrane oxygenation
    H Mulla
    Glenfield Hospital, De Montfort University Centre for Pharmacy Practice Research, Leicester, UK
    Perfusion 15:21-6. 2000
    Sedative agents are routinely administered to critically ill patients, both on and off extracorporeal membrane oxygenation (ECMO), to enable patients to be comfortable and facilitate patient management...
  89. ncbi Extracorporeal membrane oxygenation for severe influenza A (H1N1) acute respiratory distress syndrome: a prospective observational comparative study
    Antoine Roch
    Service de Reanimation, Hopital Sainte Marguerite, hopitaux Sud, 13274, Marseille Cedex 9, France
    Intensive Care Med 36:1899-905. 2010
    To compare characteristics, clinical evolution and outcome in adult patients with influenza A (H1N1) acute respiratory distress syndrome (ARDS) treated with or without extracorporeal membrane oxygenation (ECMO).
  90. ncbi "Benign" extra-axial fluid in survivors of neonatal intensive care
    Scott A Lorch
    Center for Outcomes Research, Department of Neonatology, The Children s Hospital of Philadelphia, 3535 Market Street, Suite 1029, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 158:178-82. 2004
    ..To identify the prevalence of "benign" extra-axial fluid (BEAF), the risk factors associated with this condition, and the natural history in "graduates" of neonatal intensive care...
  91. ncbi Inter-hospital transportation of patients with severe acute respiratory failure on extracorporeal membrane oxygenation--national and international experience
    V Linden
    Department of Pediatric Anesthesiology and Intensive Care, Astrid Lindgren Children s Hospital, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Intensive Care Med 27:1643-8. 2001
    To evaluate the experiences and results from inter-hospital transportation of patients with acute respiratory failure on extracorporeal membrane oxygenation (ECMO).
  92. ncbi Transportation of critically ill patients on extracorporeal membrane oxygenation
    K Wagner
    Department of Anesthesiology and Intensive Care Medicine, Rikshospitalet University Hospital, Oslo, Norway
    Perfusion 23:101-6. 2008
    Serious pulmonary and cardiac failure may be treated with extracorporeal membrane oxygenation (ECMO) when conventional treatment fails...
  93. ncbi Survival in congenital diaphragmatic hernia: use of predictive equations in the ECMO population
    Suma B Hoffman
    Department of Pediatrics, Children s National Medical Center, George Washington University School of Medicine, Washington, D C, USA
    Neonatology 99:258-65. 2011
    ..These models have not been applied specifically to the CDH ECMO (extracorporeal membrane oxygenation) population, a group at highest mortality risk.
  94. ncbi Extracorporal life support for pulmonary hemorrhage in children: a case series
    Nikoleta S Kolovos
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, USA
    Crit Care Med 30:577-80. 2002
    ..To examine the use and outcome of extracorporeal life support in children with severe respiratory failure caused by pulmonary hemorrhage...
  95. ncbi Risk factors for mortality in 137 pediatric cardiac intensive care unit patients managed with extracorporeal membrane oxygenation
    Marilyn C Morris
    Children s Hospital of Philadelphia, Department of Anesthesia and Critical Care Medicine, USA
    Crit Care Med 32:1061-9. 2004
    To identify factors associated with mortality in children with heart disease managed with extracorporeal membrane oxygenation (ECMO).
  96. ncbi The first case of severe novel H1N1 influenza successfully rescued by extracorporeal membrane oxygenation in Taiwan
    Tsui Mai Kao
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 108:894-8. 2009
    ..b>Extracorporeal membrane oxygenation (ECMO) support may successfully rescue these severely ill patients...
  97. ncbi Continuous renal replacement therapy to reduce inflammation in a piglet hemorrhage-reperfusion extracorporeal membrane oxygenation model
    Thornton S Mu
    Department of Pediatrics, Tripler Army Medical Center, Honolulu, Hawaii, USA
    Pediatr Res 72:249-55. 2012
    During extracorporeal membrane oxygenation (ECMO), circulation of blood across synthetic surfaces triggers an inflammatory response...
  98. ncbi A review of the fundamental principles and evidence base in the use of extracorporeal membrane oxygenation (ECMO) in critically ill adult patients
    Steve Allen
    Department of Surgery, Division of Traumatology and Surgical Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Intensive Care Med 26:13-26. 2011
    b>Extracorporeal membrane oxygenation (ECMO) comprises a commonly used method of extracorporeal life support...
  99. ncbi Extra corporeal membrane oxygenation and plasmapheresis for pulmonary hemorrhage in microscopic polyangiitis
    Hemant Shyam Agarwal
    Division of Pediatric Critical Care, Vanderbilt Children s Hospital, Nashville, TN 37212, USA
    Pediatr Nephrol 20:526-8. 2005
    Early initiation of extracorporeal membrane oxygenation to treat acute hypoxemic respiratory failure secondary to massive pulmonary hemorrhage in microscopic polyangiitis in children can be life-saving while awaiting control of the ..
  100. ncbi Experience in the management of eighty-two newborns with congenital diaphragmatic hernia treated with high-frequency oscillatory ventilation and delayed surgery without the use of extracorporeal membrane oxygenation
    Valérie Datin-Dorriere
    Service de réanimation néonatale, Universite Paris Descartes, Faculté de Médecine AP HP, Hopital Necker Enfants Malades, Paris, France
    J Intensive Care Med 23:128-35. 2008
    ..diaphragmatic hernia with early high-frequency ventilation and delayed surgery but excluding extracorporeal membrane oxygenation, survival rates compare favorably with other reported series, and the respiratory morbidity is low.
  101. ncbi Argatroban in extracorporeal membrane oxygenation
    Martin Beiderlinden
    Klinik für Anästhesiologie und Intensivmedizin Universitätsklinikum Essen, Universitat Duisburg Essen, Germany
    Artif Organs 31:461-5. 2007
    ..approved for anticoagulation in patients with heparin-induced thrombocytopenia (HIT) undergoing extracorporeal membrane oxygenation (ECMO)...

Research Grants62

  1. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
    ..Non-responders to iNO therapy are supported via extracorporeal membrane oxygenation (ECMO)...
  2. Attenuation of Ischemia-Reperfusion Injury in Limb Auto- and Allografts
    GEOFFROY COURCELLE SISK; Fiscal Year: 2013
    ..Often, the 4-hour time limit prohibits surgical limb salvage. Extracorporeal membrane oxygenation (ECMO) was developed to support patients incapable of adequate oxygen delivery, and has been ..
  3. Phase II Trial of Sildenafil in Newborns with Persistent Pulmonary Hyptertension
    Robin H Steinhorn; Fiscal Year: 2010
    ..in randomized, controlled trials, approximately 40% of newborns still required treatment with extracorporeal membrane oxygenation (ECMO) because of the failure of INO therapy to cause sustained improvement in oxygenation...
  4. A point-of-care device for generating nitric oxide for inhalation
    Robert L Whalen; Fiscal Year: 2011
    ..level, inhaled NO remains cost-effective compared with alternative, more invasive therapies such as extracorporeal membrane oxygenation. We are proposing to develop and test a compact point-of-care device that will generate unlimited ..
  5. Kidney Injury and Dysfunction Support (KIDS)
    Matthew Paden; Fiscal Year: 2010
    ..blood transfusion needs, and lack of compatibility with other extracorporeal devices such as extracorporeal membrane oxygenation. For this Challenge Grant, we have assembled a multi-disciplinary team of pediatricians and ..
  6. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Extracorporeal membrane oxygenation (ECMO) remains the primary method of long term support after myocardial stunning caused by cardiac surgery in infants and children...
  7. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
    ..full gas transfer requirements with significantly less coagulation and inflammation than with extracorporeal membrane oxygenation (ECMO). Our group's previous work has led to devices that met these goals in large animals...
  8. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2011
    ..pediatric cardiopulmonary assist system (pCAS) has been designed and developed as a next-generation extracorporeal membrane oxygenation (ECMO) - also called extracorporeal life support (ECLS) - system that provides increased ..
  9. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2012
    ..pediatric cardiopulmonary assist system (pCAS) has been designed and developed as a next-generation extracorporeal membrane oxygenation (ECMO) - also called extracorporeal life support (ECLS) - system that provides increased ..
  10. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2013
    ..pediatric cardiopulmonary assist system (pCAS) has been designed and developed as a next-generation extracorporeal membrane oxygenation (ECMO) - also called extracorporeal life support (ECLS) - system that provides increased ..
  11. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2010
    ..pediatric cardiopulmonary assist system (pCAS) has been designed and developed as a next-generation extracorporeal membrane oxygenation (ECMO) - also called extracorporeal life support (ECLS) - system that provides increased ..
  12. Development of the CircuLite Nano Pump and Infant Cannula System
    BRYAN PATRICK FRITZ; Fiscal Year: 2013
    ..In the U.S., there are only two current options to treat infants (less than 10 kg), extracorporeal membrane oxygenation or ECMO and the Berlin Heart EXCOR...
  13. PumpKIN Preclinical Program
    Bartley Griffith; Fiscal Year: 2012
    ..become refractory to conventional therapies, aggressive mechanical circulatory intervention through extracorporeal membrane oxygenation (ECMO) or ventricular assist devices (VADs), may improve the likelihood of survival...
  14. PumpKIN Preclinical Program
    JANET SIMONS; Fiscal Year: 2011
    ..become refractory to conventional therapies, aggressive mechanical circulatory intervention through extracorporeal membrane oxygenation (ECMO) or ventricular assist devices (VADs), may improve the likelihood of survival...
  15. PumpKIN Preclinical Program
    Bartley Griffith; Fiscal Year: 2013
    ..become refractory to conventional therapies, aggressive mechanical circulatory intervention through extracorporeal membrane oxygenation (ECMO) or ventricular assist devices (VADs), may improve the likelihood of survival...
  16. PumpKIN Preclinical Program
    JANET SIMONS; Fiscal Year: 2010
    ..become refractory to conventional therapies, aggressive mechanical circulatory intervention through extracorporeal membrane oxygenation (ECMO) or ventricular assist devices (VADs), may improve the likelihood of survival...
  17. Noninvasive Methemoglobin Monitoring Technology
    LEONARD WINCHESTER; Fiscal Year: 2007
    ..The inhaled nitric oxide therapy effectively decreases the need for extracorporeal membrane oxygenation treatment...
  18. FETAL TRACHEAL OCCLUSION FOR SEVERE DIAPHAGMATIC HERNIA
    Craig Albanese; Fiscal Year: 2000
    ..a very poor prognosis with the highest quality and most expensive postnatal treatment including extracorporeal membrane oxygenation, sophisticated ventilatory techniques, and surfactant therapy...
  19. Surface Enhanced Biocompatible Blood Oxygenators
    Daniel Campos; Fiscal Year: 2010
    ..In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respiratory distress syndrome, and artificial lungs...
  20. First-in-Human Use of an Artificial Lung for Ambulatory Respiratory Support
    ZHONGJUN JON WU; Fiscal Year: 2013
    ..Currently, when mechanical ventilation fails only extracorporeal membrane oxygenation (ECMO) systems with components designed and qualified for a few hours are available...
  21. Paracorporeal Ambulatory Assist Lung
    William R Wagner; Fiscal Year: 2013
    ..b>Extracorporeal membrane oxygenation (ECMO) can provide longer term respiratory support but is complex and significantly limits a ..
  22. PREVENTION OF ORGAN INJURY DURING CARDIOPULMONARY BYPASS
    DUKE CAMERON; Fiscal Year: 1993
    ..Mollification of PPS would significantly improve the safety of cardiac surgical procedures, mechanical circulatory assistance, and extracorporeal membrane oxygenation (ECMO).
  23. Novel Dense Hollow Fiber for Blood Gas Exchange
    JEAN MONTOYA; Fiscal Year: 2010
    ..Our patented silicone hollow fiber has great commercial potential for use in long term extracorporeal membrane oxygenation (ECMO) as well as routine cardiopulmonary bypass...
  24. ANALYSIS OF BLOOD TRAUMA FROM MICROPOROUS OXYGENATORS
    Robert Eberhart; Fiscal Year: 1991
    ..A canine model of extracorporeal membrane oxygenation (ECMO), the animal perfused in the partial veno-arterial mode, will be used for this evaluation...
  25. Biocompatible Coating for Pediatric Blood Oxygenators - Phase II
    Patrick Cahalan; Fiscal Year: 2009
    Many oxygenators clinically available for pediatric (and adult) extracorporeal membrane oxygenation (ECMO) utilize heparin coatings such as Carmeda BioActive Surface on device surfaces, including the microporous hollow fibers, to ..
  26. Biocompatible Coating for Pediatric Blood Oxygenators
    Patrick Cahalan; Fiscal Year: 2006
    ..applicant): Project Summary/Abstract: Many oxygenators clinically available for adult and pediatric extracorporeal membrane oxygenation (ECMO) employ heparin coatings on microporous hollow fibers to improve biocompatibility...
  27. Integrated Maglev Pump-Oxygenator for Respiratory Support
    Kurt Dasse; Fiscal Year: 2009
    ..Current therapy for respiratory failure includes mechanical ventilation and extracorporeal membrane oxygenation (ECMO)...
  28. Pediatric Cardiac Monitor for Extracorporeal Life Support
    Nikolai M Krivitski; Fiscal Year: 2010
    ..at the end of the surgery requiring cardiopulmonary bypass, and at the conclusion of Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO)...
  29. Pediatric Cardiac Monitor for Extracorporeal Life Support
    Nikolai Krivitski; Fiscal Year: 2005
    ..to assess the cardiac function at the end of bypass surgery and prior to weaning the patient from extracorporeal membrane oxygenation (ECMO), to quantitatively evaluate the effectiveness of the therapy...
  30. NEUROLOGIC STUDIES IN REQUIRED ECMO
    LEONARD GRAZIANI; Fiscal Year: 1991
    b>Extracorporeal Membrane Oxygenation (ECMO) is a temporary procedure for treating human neonates who have reversible, severely impaired lung function refractory to conventional treatment...
  31. MICROWAVE DEVICE FOR BLOOD WARMING & TEMPERATURE CONTROL
    RICHARD GRABOWY; Fiscal Year: 1991
    ..To address this problem, extracorporeal membrane oxygenation (ECMO) is used to provide external pumping and membrane oxygenation to assist the weakened of ..
  32. ALTERNATIVES TO ECMO FOR PEDIATRIC CIRCULATORY SUPPORT
    George Pantalos; Fiscal Year: 2002
    ..A current common practice is to support these patients with extracorporeal membrane oxygenation circuitry (ECMO), even when the indications for support are purely cardiac, due to the clinical ..
  33. An Artificial Myocardium for Pediatric Support
    Robert Stewart; Fiscal Year: 2003
    ..e., centrifugal pumps, usually with extracorporeal membrane oxygenation (ECMO))...
  34. DISPOSABLE, MAGNETICALLY SUSPENDED BLOOD PUMP
    Hsiang Chen; Fiscal Year: 2000
    ..applications inculde cardiopulmonary bypass (CPB) circuits, postcardiotomy- assist cases, and extracorporeal membrane oxygenation (ECMO)...
  35. Pediatric ECMO Catheters
    Richard Martin; Fiscal Year: 2004
    This proposal is for the development of specialty catheters designed to make single catheter ECMO (Extracorporeal Membrane Oxygenation) available to pediatric patients over 14 kg...
  36. Positional mapping of a gene for Alveolar Capillary Dys*
    Bassem Bejjani; Fiscal Year: 2004
    ..include mechanical ventilation, high concentrations of inspired oxygen, inhaled nitric oxide, and extracorporeal membrane oxygenation (ECMO) support...
  37. Integrated Maglev Pump-Oxygenator for Respiratory Support
    Kurt Dasse; Fiscal Year: 2006
    ..Current treatment is limited to extracorporeal membrane oxygenation (ECMO), but ECMO systems are generally assembled from multiple, unmatched components to create a ..
  38. Pneumatically actuated integrated life support system
    Mark Gartner; Fiscal Year: 2002
    ..MedEvac" field as a potential enabling technology to improve safety of transports with patients on extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass (CPB)...
  39. An Artificial Myocardium for Pediatric Support
    Robert Stewart; Fiscal Year: 2007
    ..This is in spite of the fact that most cases for cardiac support via extracorporeal membrane oxygenation (ECMO) are for infants following complex surgical reconstructions for congenital defects...
  40. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
  41. FOURTH INTERNATIONAL CONFERENCE ON PEDIATRIC CARDIAC DEVICES
    Akif Undar; Fiscal Year: 2008
    ..This will be the only national/international conference to focus solely on pediatric cardiac patients. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  42. PEDIATRIC MECHANICAL CIRCULATORY SUPPORT SYSTEMS
    Akif Undar; Fiscal Year: 2005
    ..The manuscripts from all of the contributors including key note, invited, slide and poster presenters will be peer-reviewed and will be published in the November-December 2005 issue of the ASAIO Journal. ..
  43. SECOND INTERNATIONAL CONFERENCE PEDIATRIC CARDIAC DEVICE
    Akif Undar; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  44. Venoarterial ECMO and neonatal cerebrovascular injury
    Billie Short; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) One of the complications of venoarterial extracorporeal membrane oxygenation (VA ECMO), an accepted rescue therapy for term and near-term infants in respiratory failure, is the development of major ..
  45. Automatic Control Of Rotary Cardiovascular Assist Device
    Fernando Casas; Fiscal Year: 2007
    ..of Albany, NY on several rotary blood pump projects. In addition, an advisory committee of highly regarded biomedical researchers will provide scientific and career advice. ..
  46. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..
  47. CLONING OF A POTENTIAL REGULATOR OF THE DHAND FACTOR
    Mark Russell; Fiscal Year: 2002
    ....
  48. LUNG INJURY, PERFLUOROCARBONS, AND HEMORRHAGIC SHOCK
    JOHN YOUNGER; Fiscal Year: 2003
    ....
  49. SURGICAL STUDIES OF SEVERE RESPIRATORY FAILURE
    Joseph Zwischenberger; Fiscal Year: 2004
    ....
  50. PAL: Pre-Clinical Fabrication & Outcomes Studies
    Joseph Zwischenberger; Fiscal Year: 2004
    ..The knowledge gained will provide unique insight into the pathophysiology of ARDS and yield outcomes data for final PAL preclinical development. ..
  51. Project PROTECT II
    Gordon Bernard; Fiscal Year: 2003
    ..abstract_text> ..
  52. Economic Analysis of Pulmonary Artery Catheter Use
    Derek Angus; Fiscal Year: 2004
    ..abstract_text> ..
  53. Schizophrenia Predisposition in 22q11 Deletion Syndrome
    Vandana Shashi; Fiscal Year: 2005
    ..abstract_text> ..
  54. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  55. Perinatal Regionalization and Quality of Care
    Scott Lorch; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. Role of Obscurin and Obscurin-MLCK in myofibrillogenesis
    Mark Russell; Fiscal Year: 2008
    ..Characterizing obscurin's roles in new myofibril assembly and in sarcomere-sarcoplasma organization may identify new strategies to treat congestive heart failure and prevent myofibril damage during ischemia. ..
  57. Interleukin-10 Therapy for Bronchopulmonary Dysplasia
    Dennis Davidson; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. Long-Term Outcomes of NO for Ventilated Premature Babies
    Derek Angus; Fiscal Year: 2007
    ..Finally, our data will allow assessment of the robustness of early proxies for subsequent outcomes, key for future study design in this area. ..
  59. Early Diagnosis of Neonatal Candidiasis
    Daniel Benjamin; Fiscal Year: 2008
    ..abstract_text> ..
  60. Chronic Lung Allograft Rejection in MHC-Defined Swine
    James Allan; Fiscal Year: 2005
    ..abstract_text> ..