artificial respiration

Summary

Summary: Any method of artifical breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2 ) and excretion of carbon dioxide (CO2 ).

Top Publications

  1. ncbi The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    Am J Respir Crit Care Med 166:1338-44. 2002
  2. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
  3. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
  4. ncbi Clinical and economic consequences of ventilator-associated pneumonia: a systematic review
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Crit Care Med 33:2184-93. 2005
  5. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
  6. ncbi Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network
    L J Van Marter
    Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 105:1194-201. 2000
  7. ncbi What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
  8. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
  9. pmc Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90024 1922, USA
    J Clin Invest 110:1703-16. 2002
  10. ncbi Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial
    M Antonelli
    Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Rome, Italy
    JAMA 283:235-41. 2000

Research Grants

Detail Information

Publications280 found, 100 shown here

  1. ncbi The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    Am J Respir Crit Care Med 166:1338-44. 2002
    ..Our nurses described RASS as logical, easy to administer, and readily recalled. RASS has high reliability and validity in medical and surgical, ventilated and nonventilated, and sedated and nonsedated adult ICU patients...
  2. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
    ..Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS...
  3. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  4. ncbi Clinical and economic consequences of ventilator-associated pneumonia: a systematic review
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Crit Care Med 33:2184-93. 2005
    ..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature..
  5. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  6. ncbi Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network
    L J Van Marter
    Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 105:1194-201. 2000
    ..To explore the hypothesis that variation in respiratory management among newborn intensive care units (NICUs) explains differences in chronic lung disease (CLD) rates...
  7. ncbi What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
    ..Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI...
  8. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
    ..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
  9. pmc Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90024 1922, USA
    J Clin Invest 110:1703-16. 2002
    ..These findings were confirmed using CXCR2(-/-) mice. Together these experiments support the notion that increased expression of KC/CXCL1 and MIP-2/CXCL2/3 and their interaction with CXCR2 are important in the pathogeneses of VILI...
  10. ncbi Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial
    M Antonelli
    Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Rome, Italy
    JAMA 283:235-41. 2000
    ..Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure...
  11. pmc Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
    Oriol Roca
    Intensive Care Department General Area, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, C P 08035 Barcelona, Spain
    Crit Care 12:R72. 2008
    ..Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI...
  12. ncbi Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia
    Manuel Iregui
    Pulmonary and Critical Care Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 122:262-8. 2002
    ..To determine the influence of initially delayed appropriate antibiotic treatment (IDAAT) on the outcomes of patients with ventilator-associated pneumonia (VAP)...
  13. ncbi Mechanical ventilation alters the immune response in children without lung pathology
    Frans B Plötz
    Pediatric Intensive Care Unit, University Medical Center Utrecht, The Netherlands
    Intensive Care Med 28:486-92. 2002
    ..This study was undertaken to examine the hypothesis that mechanical ventilation in association with anesthesia would alter the cytokine profile in infants without preexisting lung pathology...
  14. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  15. ncbi Noninvasive ventilation in acute respiratory failure--a meta-analysis update
    John V Peter
    Intensive Care Unit, The Queen Elizabeth Hospital, Woodville, SA, Australia
    Crit Care Med 30:555-62. 2002
    ..To present a meta-analytic update on the effects of noninvasive ventilation (NIV) in the management of acute respiratory failure...
  16. ncbi Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  17. ncbi Ventilator-induced lung injury: in vivo and in vitro mechanisms
    Michael A Matthay
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L678-82. 2002
    ....
  18. ncbi Pathogenesis of ventilator-induced lung injury: trials and tribulations
    Lorraine N Tremblay
    Am J Physiol Lung Cell Mol Physiol 288:L596-8. 2005
  19. ncbi Ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
    Am J Respir Crit Care Med 165:867-903. 2002
    ..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
  20. ncbi What is ventilator-associated pneumonia and why is it important?
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Respir Care 50:714-21; discussion 721-4. 2005
    ..Additionally, clinical strategies aimed at the prevention of HAP and VAP should be employed in all hospital settings caring for patients at risk for these infections...
  21. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  22. ncbi Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease
    Timothy F Feltes
    Ohio State University and The Children s Hospital, 700 Children s Drive, ED622, Columbus, OH 43205, USA
    J Pediatr 143:532-40. 2003
    ..To evaluate the safety, tolerance, and efficacy of palivizumab in children with hemodynamically significant congenital heart disease (CHD)...
  23. ncbi Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
    ..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
  24. ncbi Pulmonary contusion: review of the clinical entity
    S M Cohn
    Section of Trauma and Surgical Critical Care, Yale University School of Medicine, New Haven, Connecticut, USA
    J Trauma 42:973-9. 1997
    ..Although management of patients with pulmonary contusion is supportive, pneumonia and adult respiratory distress syndrome with long-term disability occur frequently...
  25. ncbi Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, T1217 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 170:766-72. 2004
    ..To improve outcomes further, new treatment strategies targeted at the endothelium should be investigated...
  26. ncbi Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine and the Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 33:2228-34. 2005
    ..A second objective was to determine the accuracy of clinical diagnoses of ARDS made in daily practice...
  27. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  28. ncbi Oxygenation index predicts outcome in children with acute hypoxemic respiratory failure
    Daniel Trachsel
    Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Am J Respir Crit Care Med 172:206-11. 2005
    ..This is best reflected by the OI, which shows a direct correlation to outcome in a time-independent manner...
  29. ncbi Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants
    Linda J Van Marter
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pediatr 140:171-6. 2002
    ..This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection...
  30. pmc Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilation
    Seok Mo Heo
    Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    Clin Infect Dis 47:1562-70. 2008
    ....
  31. pmc Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
    Anne Le
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 105:1282-90. 2008
    ....
  32. ncbi Increased use of noninvasive ventilation in French intensive care units
    Alexandre Demoule
    Service de Reanimation Medicale, AP HP, Hopital Henri Mondor, 51 Av du Mal de Lattre de Tassigny, 94000, Creteil, France
    Intensive Care Med 32:1747-55. 2006
    ..A prospective survey of French intensive care units (ICUs) in 1997 showed moderate and variable use of noninvasive ventilation (NIV). This study examined changes in NIV use in French ICUs after the intervening 5years...
  33. ncbi Evaluation of delivery of enteral nutrition in critically ill patients receiving mechanical ventilation
    Debra O'Meara
    Department of Nursing, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Crit Care 17:53-61. 2008
    ..Published reports consistently describe incomplete delivery of prescribed enteral nutrition. Which specific step in the process delays or interferes with the administration of a full dose of nutrients is unclear...
  34. ncbi Benefits and risks of success or failure of noninvasive ventilation
    Alexandre Demoule
    Service de Reanimation Medicale, AP HP, Hopital Henri Mondor, 51 Av du Mal de Lattre de Tassigny, 94000, Creteil, France
    Intensive Care Med 32:1756-65. 2006
    ..The impact of NIV failure and success was compared between de novo and CPE or AOC after adjustment for disease severity...
  35. ncbi The prognosis of acute respiratory failure in critically ill cancer patients
    Elie Azoulay
    Medical Intensive Care Unit, Biostatistics Department, Saint Louis Hospital and Paris 7 University, Paris, France
    Medicine (Baltimore) 83:360-70. 2004
    ..The impact of conventional mechanical ventilation on survival depends on the time from ICU admission to conventional mechanical ventilation and on the patient's response to noninvasive mechanical ventilation...
  36. ncbi Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
    Muhittin Tasdogan
    Department of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey
    J Clin Anesth 21:394-400. 2009
    ....
  37. ncbi Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells
    Kenneth E Chapman
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 289:L834-41. 2005
    ..NADPH oxidase activity was increased after 2 h of CMS, contributing to the production of O2-. Increased ROS production in lung epithelial cells in response to elevated stretch may contribute to the onset of VILI...
  38. ncbi Hospital volume and the outcomes of mechanical ventilation
    Jeremy M Kahn
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98104, USA
    N Engl J Med 355:41-50. 2006
    ..The relationship between the number of patients admitted (hospital volume) and outcome among patients with critical illnesses is unknown...
  39. pmc Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease
    Neil MacIntyre
    Duke University Medical Center, Durham, NC 27710, USA
    Proc Am Thorac Soc 5:530-5. 2008
    ..Although mild episodes of AECOPD are generally reversible, more severe forms of respiratory failure are associated with a substantial mortality and a prolonged period of disability in survivors...
  40. ncbi Hyperoxia in the intensive care unit: why more is not always better
    William A Altemeier
    Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Curr Opin Crit Care 13:73-8. 2007
    ..This review identifies relevant new findings regarding hyperoxic lung injury in the context of providing guidance for future clinical studies...
  41. ncbi Difficult Airway Society guidelines for management of the unanticipated difficult intubation
    J J Henderson
    Anaesthetic Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK
    Anaesthesia 59:675-94. 2004
    ..The flow-charts are simple, clear and definitive. They can be fully implemented only when the necessary equipment and training are available. The guidelines received overwhelming support from the membership of the DAS...
  42. ncbi Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
    V M Ranieri
    Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
    JAMA 282:54-61. 1999
    ....
  43. ncbi Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients
    Christophe Barbier
    Medical and Surgical Intensive Care Unit, Hospital St Germain en Laye, 20 rue Armagis, 78100 St Germain en Laye, France
    Intensive Care Med 30:1740-6. 2004
    ..To evaluate the extent to which respiratory changes in inferior vena cava (IVC) diameter can be used to predict fluid responsiveness...
  44. ncbi Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 108:46-54. 2008
    ..The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury...
  45. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  46. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  47. ncbi Superior vena caval collapsibility as a gauge of volume status in ventilated septic patients
    Antoine Vieillard-Baron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France
    Intensive Care Med 30:1734-9. 2004
    ..We tested the hypothesis that measurement of superior vena caval collapsibility would reveal the need for volume expansion in a given septic patient...
  48. ncbi Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    Alan R Hauser
    Department of Microbiology Immunology, Northwestern University, Chicago, IL, USA
    Crit Care Med 30:521-8. 2002
    ..The objective of this study was to determine whether this system contributes to disease severity in humans with ventilator-associated pneumonia...
  49. pmc Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice
    Esther K Wolthuis
    Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care 13:R1. 2009
    ..To study VILI in healthy mice, the authors used a MV model with clinically relevant ventilator settings, avoiding massive damage of lung structures and shock, and preventing metabolic acidosis...
  50. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
    ..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
  51. ncbi The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery
    Hermann Wrigge
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Anesth Analg 98:775-81, table of contents. 2004
    ..Our data suggest that the ventilatory settings we studied do not affect inflammatory reactions during major surgery within 3 h...
  52. ncbi Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
    ....
  53. ncbi Severe agitation among ventilated medical intensive care unit patients: frequency, characteristics and outcomes
    Jeffery C Woods
    Critical Care and Step down Nursing, Huron Hospital, Cleveland, Ohio, USA
    Intensive Care Med 30:1066-72. 2004
    ..To determine the frequency, characteristics and outcomes of severe agitation among ventilated medical intensive care unit (MICU) patients...
  54. ncbi Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area
    Christopher M Booth
    University of Toronto, Mount Sinai Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 289:2801-9. 2003
    ..Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in China in November 2002 and has subsequently spread worldwide...
  55. ncbi Ventilator-induced diaphragmatic dysfunction
    Theodoros Vassilakopoulos
    Respiratory Division, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 169:336-41. 2004
  56. ncbi Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia
    Marco Confalonieri
    Struttura Complessa Pneumologia, Azienda Ospedaliera di Trieste, U O Pneumologia, via Bonomea 265, 34100 Trieste, Italy
    Intensive Care Med 28:1233-8. 2002
    ..To compare noninvasive positive pressure ventilation (NPPV) vs. invasive mechanical ventilation in AIDS patients with Pneumocystis carinii pneumonia (PCP)-related acute respiratory failure (ARF)...
  57. ncbi Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial
    G Conti
    Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo F Vito, 00168 Rome, Italy
    Intensive Care Med 28:1701-7. 2002
    ....
  58. ncbi Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  59. ncbi Secular trends in nosocomial infections and mortality associated with noninvasive ventilation in patients with exacerbation of COPD and pulmonary edema
    Emmanuelle Girou
    Unité d Hygiène et Prévention de l Infection, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    JAMA 290:2985-91. 2003
    ..But whether these benefits translate to a clinical setting is unclear...
  60. ncbi Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation
    M Confalonieri
    Unità Operativa di Pneumologia, Ospedale Civile di Piacenza, Piacenza, Italy
    Am J Respir Crit Care Med 160:1585-91. 1999
    ..A 2-mo survival advantage was seen in patients with COPD...
  61. ncbi Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions
    R M Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, West Sussex, UK
    Br J Anaesth 87:684-90. 2001
    ..The rate pressure product is reduced in patients receiving dexmedetomidine, which may protect against myocardial ischaemia. Dexmedetomidine reduces the requirement for opioid analgesia...
  62. ncbi Noninvasive positive pressure ventilation in the acute care setting: where are we?
    N Ambrosino
    Pulmonary and Respiratory Intensive Care Unit, Cardio Thoracic Dept, University Hospital Pisa, Italy
    Eur Respir J 31:874-86. 2008
    ..Additionally, the technique must be applied in the appropriate location by a trained team in order to avoid disappointing results...
  63. ncbi Electrical impedance tomography compared with thoracic computed tomography during a slow inflation maneuver in experimental models of lung injury
    Hermann Wrigge
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    Crit Care Med 36:903-9. 2008
    ....
  64. ncbi The impact of nosocomial infections on patient outcomes following cardiac surgery
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 112:666-75. 1997
    ..To evaluate the relationship between nosocomial infections and clinical outcomes following cardiac surgery, and to identify risk factors for the development of nosocomial infections in this patient population...
  65. ncbi The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patients
    Cyril Charron
    Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
    Anesth Analg 102:1511-7. 2006
    ..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
  66. ncbi Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 31:1312-7. 2003
    ..To determine the attributable cost of ventilator-associated pneumonia from a hospital-based cost perspective, after adjusting for potential confounders...
  67. ncbi Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage
    James E Baumgardner
    Department of Anesthesia, School of Veterinary Medicine, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Am J Respir Crit Care Med 166:1556-62. 2002
    ..The important effect of RR on the magnitude of PaO2 oscillations suggests that the static behavior of atelectasis cannot be accurately extrapolated to predict dynamic behavior at realistic breathing frequencies...
  68. ncbi Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome
    Carlos M Luna
    Pulmonary and Critical Care Divisions, Department of Medicine, Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Argentina
    Crit Care Med 31:676-82. 2003
    ..To prospectively evaluate the performance of the Clinical Pulmonary Infection Score (CPIS) and its components to identify early in the hospital course of ventilator-associated pneumonia (VAP) which patients are responding to therapy...
  69. ncbi Device-associated, device-day infection rates in an Israeli adult general intensive care unit
    R Finkelstein
    Infectious Diseases Unit, Rambam Medical Center Technion Israel Institute of Technology, Faculty of Medicine Haifa, Israel
    J Hosp Infect 44:200-5. 2000
    ..The present study provides specific surveillance data for further interhospital comparison with similar types of ICUs...
  70. ncbi Postnatal risk factors of retinopathy of prematurity
    Tae Im Kim
    Department of Ophthalmology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea
    Paediatr Perinat Epidemiol 18:130-4. 2004
    ..In addition, apnoea may not only increase the risk of developing ROP, but may also worsen pre-existing ROP...
  71. ncbi Chorioamnionitis alters the response to surfactant in preterm infants
    Jasper V Been
    Department of Paediatrics, School for Oncology and Developmental Biology GROW, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Pediatr 156:10-15.e1. 2010
    ..To study the association between antenatal exposure to chorioamnionitis and the neonatal response to surfactant...
  72. ncbi Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia
    P J Dennesen
    Department of Medical Microbiology, Medical Technology Assessment and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 163:1371-5. 2001
    ....
  73. ncbi Outcomes of adults hospitalised with severe influenza
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Thorax 65:510-5. 2010
    ..The aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza...
  74. ncbi Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans
    Sanford Levine
    Department of Surgery, University of Pennsylvania, USA
    N Engl J Med 358:1327-35. 2008
    ..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm...
  75. ncbi [Diagnostic value of quantitative cultures of endotracheal aspirate in ventilator-associated pneumonia: a multicenter study]
    M Valencia Arango
    Unidad de Cuidados Intensivos Universidad Pontificia Bolivariana Medellín Colombia, and Hospital Clínic Barcelona España
    Arch Bronconeumol 39:394-9. 2003
    ..To study the validity of quantitative cultures of tracheal aspirate (TA) in comparison with the plugged telescoping catheter (PTC) for the diagnosis of mechanical ventilator-associated pneumonia...
  76. ncbi Is there a safe plateau pressure in ARDS? The right heart only knows
    Francois Jardin
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, France
    Intensive Care Med 33:444-7. 2007
    ..The objective of the present study was to examine if the echocardiographic evaluation of right ventricular function performed in ARDS may help to answer to this question...
  77. ncbi Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma
    Philippe Seguin
    Surgical Intensive Care Unit, INSERM U620, Hopital Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
    Crit Care Med 34:1514-9. 2006
    ..To evaluate the effect of a regular oropharyngeal application of povidone-iodine on the prevalence of ventilator-associated pneumonia in patients with severe head trauma...
  78. ncbi Ventilator-induced cell wounding and repair in the intact lung
    Ognjen Gajic
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 167:1057-63. 2003
    ..25 +/- 0.09 to 0.08 +/- 0.08, p < 0.01). We conclude that cells of ventilator-injured lungs are subject to reversible plasma membrane stress failure...
  79. pmc Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling
    J M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25 Florida Gym, Gainesville, FL 32611, USA
    J Physiol 585:203-15. 2007
    ..Further, these results also indicate that differential regulation of diaphragmatic IGF-1-PI3K-Akt signalling exists during the early and late stages of MV...
  80. ncbi Early intervention can improve clinical outcome of acute interstitial pneumonia
    Gee Young Suh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
    Chest 129:753-61. 2006
    ....
  81. ncbi Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury
    Deborah A Quinn
    Pulmonary Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Appl Physiol (1985) 93:517-25. 2002
    ....
  82. ncbi Cystic fibrosis adult care: consensus conference report
    James R Yankaskas
    University of North Carolina, Chapel Hill, NC 27599, USA
    Chest 125:1S-39S. 2004
  83. ncbi Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study
    Monica M Lahra
    Royal Prince Alfred Hospital, Department of Neonatal Medicine, Missenden Road, Camperdown, New South Wales 2050, Australia
    Pediatrics 123:1314-9. 2009
    ..OBJECTIVE To determine the impact of intrauterine inflammation of maternal (chorioamnionitis) and fetal (umbilical vasculitis) origin and neonatal sepsis on the development of neonatal chronic lung disease in preterm infants...
  84. ncbi Early intensive care unit mobility therapy in the treatment of acute respiratory failure
    Peter E Morris
    Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Crit Care Med 36:2238-43. 2008
    ..Despite the theoretical advantages of physical therapy to address this problem, it has not been shown that physical therapy initiated in the intensive care unit offers benefit...
  85. ncbi Evolution of mechanical ventilation in response to clinical research
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
    Am J Respir Crit Care Med 177:170-7. 2008
    ..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...
  86. ncbi Is it safer to intubate premature infants in the delivery room?
    Hany Aly
    Department of Newborn Services, George Washington University Hospital, Washington, DC 20037, USA
    Pediatrics 115:1660-5. 2005
    ..We also explored potential harmful effects of early intubation and examined whether unsuccessful ENCPAP attempts might subject infants to any unforeseen morbidity...
  87. pmc Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
    Am J Respir Crit Care Med 175:150-9. 2007
    ..Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic myofiber volume/myonucleus) of diaphragm myofibers is altered during MV...
  88. ncbi Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
    ..In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear...
  89. ncbi Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy
    Abdulaziz Boker
    Department of Anesthesia and Critical Care, Abdulaziz University, Jeddah, Saudi Arabia
    Anesthesiology 100:608-16. 2004
    ..VV was compared with CV in patients undergoing abdominal aortic aneurysmectomy, a patient group known to be at risk of deteriorating lung function perioperatively...
  90. ncbi Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease
    Ikechukwu I Ekekezie
    Children s Mercy Hospitals and Clinics, University of Missouri Kansas City, School of Medicine, Department of Pediatrics, Section of Neonatal Perinatal Medicine, Kansas City, Missouri, USA
    Pediatrics 113:1709-14. 2004
    ....
  91. ncbi Prediction of fluid responsiveness in patients during cardiac surgery
    S Rex
    Department of Anaesthesiology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Br J Anaesth 93:782-8. 2004
    ..Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are unproven in patients ventilated with low tidal volumes...
  92. ncbi ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens
    Daniel L Herr
    Washington Hospital Center, Washington, DC 2010, USA
    J Cardiothorac Vasc Anesth 17:576-84. 2003
    ..To compare dexmedetomidine-based to propofol-based sedation after coronary artery bypass graft (CABG) surgery in the intensive care unit (ICU)...
  93. ncbi A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients
    Mark J Rumbak
    Department of Medicine, Division of Pulmonary, Critical Care and Occupation Medicine, Tampa General Hospital University of South Florida Health Science Center, Tampa, FL 33612, USA
    Crit Care Med 32:1689-94. 2004
    ..The effects of early percutaneous dilational tracheotomy compared with delayed tracheotomy in critically ill medical patients needing prolonged mechanical ventilation were assessed...
  94. ncbi Outcomes after long-term acute care. An analysis of 133 mechanically ventilated patients
    S S Carson
    Departments of Medicine, Robert Wood Johnson Clinical Scholars Program, University of Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 159:1568-73. 1999
    ..001). We demonstrate characteristics predicting the poorest prognoses for patients requiring prolonged mechanical ventilation. These characteristics may be identifiable before transfer to an LTAC hospital...
  95. ncbi Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis
    Josep Masip
    ICU Department, Hospital Dos de Maig Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain
    JAMA 294:3124-30. 2005
    ..In patients with acute cardiogenic pulmonary edema noninvasive ventilation may reduce intubation rate, but the impact on mortality and the superiority of one technique over another have not been clearly established...
  96. ncbi High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
  97. ncbi Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome
    Marc Gainnier
    Service de Reanimation Medicale, hopitaux Sud, Marseille, France
    Crit Care Med 32:113-9. 2004
    ..To evaluate the effects of a 48-hr neuromuscular blocking agents (NMBA) infusion on gas exchange over a 120-hr time period in patients with acute respiratory distress syndrome...
  98. ncbi Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation
    Ercole Zanotti
    Pulmonary Department, Scientific Institute of Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Italy
    Chest 124:292-6. 2003
    ....
  99. ncbi Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgery
    Daniel A Reuter
    Department of Anesthesiology, Grosshadern University Hospital, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 28:392-8. 2002
    ....
  100. ncbi Early changes in lung gene expression due to high tidal volume
    Ian B Copland
    Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 168:1051-9. 2003
    ..the effects of HV are cumulative; (2). specific patterns of gene activation and suppression precede lung injury; and (3). alteration of gene expression after mechanical stretch is pathogenic...
  101. pmc Acute respiratory distress syndrome
    Susannah K Leaver
    Department of Critical Care, Imperial College School of Medicine, Royal Brompton Hospital, London SW3 6NP
    BMJ 335:389-94. 2007

Research Grants68

  1. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2009
    ..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
  2. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2009
    ..abstract_text> ..
  3. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  4. Weaning from Prolonged Mechanical Ventilation
    Amal Jubran; Fiscal Year: 2008
    ..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. [unreadable] [unreadable]..
  5. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2008
    ..abstract_text> ..
  6. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  7. Outcomes of Prolonged Mechanical Ventilation
    Shannon Carson; Fiscal Year: 2006
    ..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
  8. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  9. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  10. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  11. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  12. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  13. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  14. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  16. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. Chemosensitivity of Tachykinin-containing Lung Afferents
    Lu Yuan Lee; Fiscal Year: 2008
    ..The results obtained from this study should provide critical information for gaining new insights into the mechanisms underlying the airway hyperresponsiveness induced by cationic proteins. [unreadable] [unreadable]..
  18. Host variability in innate inflammatory responses
    Mark Wurfel; Fiscal Year: 2007
    ..abstract_text> ..
  19. Novel device for improving standard CPR outcomes
    Keith Lurie; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Mother-Administered Interventions for VLBW Infants
    Diane Holditch Davis; Fiscal Year: 2009
    ..Cost-effectiveness of the interventions will also be determined. ..
  21. Toward Optimal End-of-Life Care in the PICU
    Robert Truog; Fiscal Year: 2010
    ....
  22. Building End-of-Life Science through Positive Human Strengths and Traits
    Barbara Daly; Fiscal Year: 2010
    ..A thorough evaluation of the activities and milestones will assist us to measure our success and promote the sustainability of the BEST Center. ..
  23. Role of TRPV1 in Airway Hypersensitivity Induced by Inflammation
    Lu Yuan Lee; Fiscal Year: 2010
    ..The results obtained from these studies should bring a new insight into the pathogenesis and therapeutic strategy for alleviating the airway hypersensitivity. ..
  24. TSP-1: A mediator of sepsis-induced lung injury
    Naeem A Ali; Fiscal Year: 2010
    ..The combined resources of this institution (tertiary care hospital, GCRC and College of Medicine and Public Health) will be available to the candidate to achieve these goals. ..
  25. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  26. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  27. Improving The Quality Of Advanced Cancer Care With Disease Management
    Barbara Daly; Fiscal Year: 2010
    ..remain after controlling for the influence of demographic, clinical and organizational covariates? (5) To what extent are differences in patient and caregiver outcomes achieved through improvements in collaboration and problem solving? ..
  28. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  29. Impedance Threshold Value for Improving Standard CPR
    Keith Lurie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Patients' Recall and Assessment of Mechanical Ventilation: Impact of Sedation
    Jill Guttormson; Fiscal Year: 2010
    ..The knowledge gained from this study has significant public health implications for patients receiving ventilatory support in the United States-improving symptom management and recovery. ..
  31. Ventilator-induced diaphragm dysfunction
    SANFORD NO MIDDLE NAME LEVINE; Fiscal Year: 2010
    ..Moreover, these studies may directly lead to therapy for this newly recognized but relatively common disease of diaphragm muscle. ..
  32. Improving Ventilator Management and Preventing Injury to Patients with ARF
    Gordon Rubenfeld; Fiscal Year: 2009
    ....
  33. Immunomodulatory Effects of Mechanical Ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2007
    ....
  34. Physiologic Genomics of Pulmonary Hypertension & RVH
    SINA GHARIB; Fiscal Year: 2008
    ..Ultimately, this mentored research career award will allow the PI to develop into an independent computational molecular biologist and pursue an academic research career in the physiologic genomics of the cardiopulmonary system. ..
  35. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2005
    ..If this study confirms the benefits seen in the pilot study, it will result in a significant improvement in health care for premature infants, both by introducing a beneficial new therapy, and by avoiding higher dose dexamethasone. ..
  36. Ventilator-Induced Lung Injury:Mechanisms & Consequences
    Scott Sinclair; Fiscal Year: 2005
    ..Aim 3A: Document cyclical airway collapse and reopening via changes in regional ventilation distribution. Aim 3B: Validate a method to estimate appropriate PEEP level to prevent cyclical airway collapse. ..
  37. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  38. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2005
    ....
  39. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ....
  40. TLR's, Nitric Oxide and Chronic Lung Disease
    William Truog; Fiscal Year: 2005
    ..Its results may also open up intriguing pathways for treatments aimed at selective diminution of pulmonary inflammation. ..
  41. Mentored Patient-Oriented Research Career Development Aw
    Heidi Flori; Fiscal Year: 2004
    ..This data will provide the first comprehensive prospective study of pediatric ALI using a standard, internationally accepted definition with a combination of epidemiological and biological markers of acute lung injury. ..
  42. PLASTICITY IN RESPIRATORY MOTOR CONTROL
    Gordon Mitchell; Fiscal Year: 2004
    ..A multidisciplinary approach will be used to test key elements of the model. ..
  43. GENETIC EPIDEMIOLOGY OF RSV BRONCHIOLITIS AND ASTHMA
    Adrienne Randolph; Fiscal Year: 2004
    ..Identifying the genes associated with the onset of childhood asthma could lead to targeted interventions aimed at prevention and treatment of this disorder that is increasing at a rate of 5 percent per year. ..
  44. ASSESSMENT OF BIOLOGICAL/SOCIAL RISK IN PRETERM INFANTS
    Diane Holditch Davis; Fiscal Year: 2001
    ....
  45. Role of the Leukotriene B4 Receptors in Asthma
    BENJAMIN MEDOFF; Fiscal Year: 2003
    ..Repeat experiments in the presence of a BLTR2 antagonist will also allow characterization of the role of this receptor in asthma. ..
  46. Nursing Support Intervention for Mothers of Prematures
    Diane Holditch Davis; Fiscal Year: 2005
    ..Child development will be measured by the Bayley II and a language assessment. ..
  47. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  48. Neurohormonal Activation in Pulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..We will formulate prediction rules using neurohormone levels and clinical variables to improve prognostication and management in this disease. ..
  49. Cytoprotection by VEGF and HO-1 in Hyperoxic Lung Injury
    JONATHAN SINER; Fiscal Year: 2005
    ..These investigations will provide insight into the cytoprotective effects of HO-1 and VEGF and mechanisms of protection from hyperoxic acute lung injury. ..
  50. The Effect of Patient Volume on Outcome in the ICU
    Jeremy Kahn; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. Advancing Clinical Research in Pediatric Surgery
    KEVIN LALLY; Fiscal Year: 2006
    ..Lally with his research and mentoring to advance the quality of clinical research in pediatric surgery, develop an expanded international trials network, and improve the outcome of high-risk infants. ..
  52. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2008
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  53. Assessing and Treating Symptoms of Dying ICU Patients
    Kathleen Puntillo; Fiscal Year: 2006
    ..Results will also contribute empirical data needed to generate and test hypotheses concerning appropriate symptom assessment and management interventions. [unreadable] [unreadable] [unreadable]..
  54. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  55. Strategies for Airway Management & Prevention Endotracheal Tube Cuff Intervention
    MARY SOLE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
    ....
  57. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2007
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  58. Comprehensive Research Training for Oral Health Sciences
    Frank Scannapieco; Fiscal Year: 2008
    ..Name Organization Frank A. Scannapieco University at Buffalo/Oral Biology Libuse Bobek University at Buffalo/Oral Biology Rosemary Dziak University at Buffalo/Oral Biology in the format shown below. Role on ..
  59. Intensive Communication for Chronically Critically Ill
    Barbara Daly; Fiscal Year: 2007
    ..ethnicity); (e) What are the key process characteristics of communication in ICS? ..
  60. THE CHRONICALLY ILL--LONG TERM MECHANICAL VENTILATION
    Barbara Daly; Fiscal Year: 2003
    ..4) Are there differences between family members of chronically critically ill patients who participate in a disease management program and family members of those who do not in care-giving burden and depression? ..
  61. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2007
    ....
  62. Autologous Cellular Therapy for Ventricular Dysfunction
    Robert Kormos; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Amylase Binding Streptococci Dental Plaque and Caries
    Frank Scannapieco; Fiscal Year: 2008
    ..mutans made to express AbpA show altered colonization and/or cariogenic abilities. Integration of in vitro with in vivo studies is crucial for mechanistic understanding of Dental plaque formation. ..
  64. Oral Health and Ventilator Associated Pneumonia
    Frank Scannapieco; Fiscal Year: 2006
    ..abstract_text> ..
  65. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..