artificial respiration

Summary

Summary: Any method of artifical breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2 ) and excretion of carbon dioxide (CO2 ).

Top Publications

  1. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
  2. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
  3. ncbi Clinical and economic consequences of ventilator-associated pneumonia: a systematic review
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Crit Care Med 33:2184-93. 2005
  4. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
  5. ncbi Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network
    L J Van Marter
    Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 105:1194-201. 2000
  6. ncbi What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
  7. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
  8. ncbi Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
  9. ncbi Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease
    Timothy F Feltes
    Ohio State University and The Children s Hospital, 700 Children s Drive, ED622, Columbus, OH 43205, USA
    J Pediatr 143:532-40. 2003
  10. ncbi Pulmonary contusion: review of the clinical entity
    S M Cohn
    Section of Trauma and Surgical Critical Care, Yale University School of Medicine, New Haven, Connecticut, USA
    J Trauma 42:973-9. 1997

Research Grants

Detail Information

Publications241 found, 100 shown here

  1. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  2. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
    ..Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS...
  3. ncbi Clinical and economic consequences of ventilator-associated pneumonia: a systematic review
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Crit Care Med 33:2184-93. 2005
    ..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature..
  4. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  5. ncbi Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network
    L J Van Marter
    Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 105:1194-201. 2000
    ..To explore the hypothesis that variation in respiratory management among newborn intensive care units (NICUs) explains differences in chronic lung disease (CLD) rates...
  6. ncbi What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
    ..Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI...
  7. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  8. ncbi Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
    ..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
  9. ncbi Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease
    Timothy F Feltes
    Ohio State University and The Children s Hospital, 700 Children s Drive, ED622, Columbus, OH 43205, USA
    J Pediatr 143:532-40. 2003
    ..To evaluate the safety, tolerance, and efficacy of palivizumab in children with hemodynamically significant congenital heart disease (CHD)...
  10. ncbi Pulmonary contusion: review of the clinical entity
    S M Cohn
    Section of Trauma and Surgical Critical Care, Yale University School of Medicine, New Haven, Connecticut, USA
    J Trauma 42:973-9. 1997
    ..Although management of patients with pulmonary contusion is supportive, pneumonia and adult respiratory distress syndrome with long-term disability occur frequently...
  11. ncbi Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine and the Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 33:2228-34. 2005
    ..A second objective was to determine the accuracy of clinical diagnoses of ARDS made in daily practice...
  12. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  13. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
    ..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
  14. pmc Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
    Anne Le
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 105:1282-90. 2008
    ....
  15. ncbi Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants
    Linda J Van Marter
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pediatr 140:171-6. 2002
    ..This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection...
  16. pmc Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilation
    Seok Mo Heo
    Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    Clin Infect Dis 47:1562-70. 2008
    ....
  17. ncbi Oxygenation index predicts outcome in children with acute hypoxemic respiratory failure
    Daniel Trachsel
    Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Am J Respir Crit Care Med 172:206-11. 2005
    ..This is best reflected by the OI, which shows a direct correlation to outcome in a time-independent manner...
  18. ncbi The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    Am J Respir Crit Care Med 166:1338-44. 2002
    ..Our nurses described RASS as logical, easy to administer, and readily recalled. RASS has high reliability and validity in medical and surgical, ventilated and nonventilated, and sedated and nonsedated adult ICU patients...
  19. ncbi Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients
    Christophe Barbier
    Medical and Surgical Intensive Care Unit, Hospital St Germain en Laye, 20 rue Armagis, 78100 St Germain en Laye, France
    Intensive Care Med 30:1740-6. 2004
    ..To evaluate the extent to which respiratory changes in inferior vena cava (IVC) diameter can be used to predict fluid responsiveness...
  20. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  21. ncbi Difficult Airway Society guidelines for management of the unanticipated difficult intubation
    J J Henderson
    Anaesthetic Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK
    Anaesthesia 59:675-94. 2004
    ..The flow-charts are simple, clear and definitive. They can be fully implemented only when the necessary equipment and training are available. The guidelines received overwhelming support from the membership of the DAS...
  22. ncbi Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 108:46-54. 2008
    ..The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury...
  23. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  24. ncbi Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
    V M Ranieri
    Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
    JAMA 282:54-61. 1999
    ....
  25. ncbi Evolution of mechanical ventilation in response to clinical research
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
    Am J Respir Crit Care Med 177:170-7. 2008
    ..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...
  26. ncbi Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    Alan R Hauser
    Department of Microbiology Immunology, Northwestern University, Chicago, IL, USA
    Crit Care Med 30:521-8. 2002
    ..The objective of this study was to determine whether this system contributes to disease severity in humans with ventilator-associated pneumonia...
  27. ncbi The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery
    Hermann Wrigge
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Anesth Analg 98:775-81, table of contents. 2004
    ..Our data suggest that the ventilatory settings we studied do not affect inflammatory reactions during major surgery within 3 h...
  28. ncbi Superior vena caval collapsibility as a gauge of volume status in ventilated septic patients
    Antoine Vieillard-Baron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France
    Intensive Care Med 30:1734-9. 2004
    ..We tested the hypothesis that measurement of superior vena caval collapsibility would reveal the need for volume expansion in a given septic patient...
  29. pmc Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice
    Esther K Wolthuis
    Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care 13:R1. 2009
    ..To study VILI in healthy mice, the authors used a MV model with clinically relevant ventilator settings, avoiding massive damage of lung structures and shock, and preventing metabolic acidosis...
  30. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
    ..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
  31. ncbi Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage
    James E Baumgardner
    Department of Anesthesia, School of Veterinary Medicine, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Am J Respir Crit Care Med 166:1556-62. 2002
    ..The important effect of RR on the magnitude of PaO2 oscillations suggests that the static behavior of atelectasis cannot be accurately extrapolated to predict dynamic behavior at realistic breathing frequencies...
  32. ncbi Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome
    Carlos M Luna
    Pulmonary and Critical Care Divisions, Department of Medicine, Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Argentina
    Crit Care Med 31:676-82. 2003
    ..To prospectively evaluate the performance of the Clinical Pulmonary Infection Score (CPIS) and its components to identify early in the hospital course of ventilator-associated pneumonia (VAP) which patients are responding to therapy...
  33. ncbi Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 31:1312-7. 2003
    ..To determine the attributable cost of ventilator-associated pneumonia from a hospital-based cost perspective, after adjusting for potential confounders...
  34. ncbi The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patients
    Cyril Charron
    Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
    Anesth Analg 102:1511-7. 2006
    ..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
  35. ncbi Postnatal risk factors of retinopathy of prematurity
    Tae Im Kim
    Department of Ophthalmology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea
    Paediatr Perinat Epidemiol 18:130-4. 2004
    ..In addition, apnoea may not only increase the risk of developing ROP, but may also worsen pre-existing ROP...
  36. doi Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  37. ncbi [Diagnostic value of quantitative cultures of endotracheal aspirate in ventilator-associated pneumonia: a multicenter study]
    M Valencia Arango
    Unidad de Cuidados Intensivos Universidad Pontificia Bolivariana Medellín Colombia, and Hospital Clínic Barcelona España
    Arch Bronconeumol 39:394-9. 2003
    ..To study the validity of quantitative cultures of tracheal aspirate (TA) in comparison with the plugged telescoping catheter (PTC) for the diagnosis of mechanical ventilator-associated pneumonia...
  38. ncbi Device-associated, device-day infection rates in an Israeli adult general intensive care unit
    R Finkelstein
    Infectious Diseases Unit, Rambam Medical Center Technion Israel Institute of Technology, Faculty of Medicine Haifa, Israel
    J Hosp Infect 44:200-5. 2000
    ..The present study provides specific surveillance data for further interhospital comparison with similar types of ICUs...
  39. doi Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans
    Sanford Levine
    Department of Surgery, University of Pennsylvania, USA
    N Engl J Med 358:1327-35. 2008
    ..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm...
  40. ncbi Outcomes of adults hospitalised with severe influenza
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Thorax 65:510-5. 2010
    ..The aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza...
  41. doi Chorioamnionitis alters the response to surfactant in preterm infants
    Jasper V Been
    Department of Paediatrics, School for Oncology and Developmental Biology GROW, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Pediatr 156:10-15.e1. 2010
    ..To study the association between antenatal exposure to chorioamnionitis and the neonatal response to surfactant...
  42. ncbi Early intervention can improve clinical outcome of acute interstitial pneumonia
    Gee Young Suh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
    Chest 129:753-61. 2006
    ....
  43. ncbi Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia
    P J Dennesen
    Department of Medical Microbiology, Medical Technology Assessment and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 163:1371-5. 2001
    ....
  44. ncbi Ventilator-induced cell wounding and repair in the intact lung
    Ognjen Gajic
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 167:1057-63. 2003
    ..25 +/- 0.09 to 0.08 +/- 0.08, p < 0.01). We conclude that cells of ventilator-injured lungs are subject to reversible plasma membrane stress failure...
  45. ncbi Is there a safe plateau pressure in ARDS? The right heart only knows
    Francois Jardin
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, France
    Intensive Care Med 33:444-7. 2007
    ..The objective of the present study was to examine if the echocardiographic evaluation of right ventricular function performed in ARDS may help to answer to this question...
  46. ncbi Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma
    Philippe Seguin
    Surgical Intensive Care Unit, INSERM U620, Hopital Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
    Crit Care Med 34:1514-9. 2006
    ..To evaluate the effect of a regular oropharyngeal application of povidone-iodine on the prevalence of ventilator-associated pneumonia in patients with severe head trauma...
  47. ncbi Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome
    Marc Gainnier
    Service de Reanimation Medicale, hopitaux Sud, Marseille, France
    Crit Care Med 32:113-9. 2004
    ..To evaluate the effects of a 48-hr neuromuscular blocking agents (NMBA) infusion on gas exchange over a 120-hr time period in patients with acute respiratory distress syndrome...
  48. ncbi ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens
    Daniel L Herr
    Washington Hospital Center, Washington, DC 2010, USA
    J Cardiothorac Vasc Anesth 17:576-84. 2003
    ..To compare dexmedetomidine-based to propofol-based sedation after coronary artery bypass graft (CABG) surgery in the intensive care unit (ICU)...
  49. ncbi Outcomes after long-term acute care. An analysis of 133 mechanically ventilated patients
    S S Carson
    Departments of Medicine, Robert Wood Johnson Clinical Scholars Program, University of Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 159:1568-73. 1999
    ..001). We demonstrate characteristics predicting the poorest prognoses for patients requiring prolonged mechanical ventilation. These characteristics may be identifiable before transfer to an LTAC hospital...
  50. ncbi Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation
    Ercole Zanotti
    Pulmonary Department, Scientific Institute of Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Italy
    Chest 124:292-6. 2003
    ....
  51. ncbi Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis
    Josep Masip
    ICU Department, Hospital Dos de Maig Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain
    JAMA 294:3124-30. 2005
    ..In patients with acute cardiogenic pulmonary edema noninvasive ventilation may reduce intubation rate, but the impact on mortality and the superiority of one technique over another have not been clearly established...
  52. ncbi Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgery
    Daniel A Reuter
    Department of Anesthesiology, Grosshadern University Hospital, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 28:392-8. 2002
    ....
  53. ncbi A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients
    Mark J Rumbak
    Department of Medicine, Division of Pulmonary, Critical Care and Occupation Medicine, Tampa General Hospital University of South Florida Health Science Center, Tampa, FL 33612, USA
    Crit Care Med 32:1689-94. 2004
    ..The effects of early percutaneous dilational tracheotomy compared with delayed tracheotomy in critically ill medical patients needing prolonged mechanical ventilation were assessed...
  54. ncbi High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
  55. ncbi Ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
    Am J Respir Crit Care Med 165:867-903. 2002
    ..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
  56. pmc Readmission rates and life threatening events in COPD survivors treated with non-invasive ventilation for acute hypercapnic respiratory failure
    C M Chu
    Division of Respiratory Medicine, Department of Medicine and Geriatrics, United Christian Hospital, Kowloon, Hong Kong, SAR, China
    Thorax 59:1020-5. 2004
    ..However, little information exists on the outcomes following discharge. A study was undertaken to examine the rates of readmission, recurrent AHRF, and death following discharge and the risk factors associated with them...
  57. pmc Acute respiratory distress syndrome
    Susannah K Leaver
    Department of Critical Care, Imperial College School of Medicine, Royal Brompton Hospital, London SW3 6NP
    BMJ 335:389-94. 2007
  58. ncbi Early changes in lung gene expression due to high tidal volume
    Ian B Copland
    Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 168:1051-9. 2003
    ..the effects of HV are cumulative; (2). specific patterns of gene activation and suppression precede lung injury; and (3). alteration of gene expression after mechanical stretch is pathogenic...
  59. ncbi Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats
    Andrea Moriondo
    Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Universita degli Studi dell Insubria, via J H Dunant 5, 21100 Varese, Italy
    J Appl Physiol 103:747-56. 2007
    ....
  60. ncbi A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients
    B D Freeman
    Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
    Crit Care Med 29:926-30. 2001
    ..PDT may become the procedure of choice for electively establishing tracheostomy in the appropriately selected patient who requires long-term mechanical ventilation...
  61. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  62. pmc Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury
    Tamas Dolinay
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e1601. 2008
    ....
  63. ncbi Is it safer to intubate premature infants in the delivery room?
    Hany Aly
    Department of Newborn Services, George Washington University Hospital, Washington, DC 20037, USA
    Pediatrics 115:1660-5. 2005
    ..We also explored potential harmful effects of early intubation and examined whether unsuccessful ENCPAP attempts might subject infants to any unforeseen morbidity...
  64. ncbi The changing epidemiology of mechanical ventilation: a population-based study
    Shannon S Carson
    Department of Medicine and the Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7020, USA
    J Intensive Care Med 21:173-82. 2006
    ..4% to 34.4%, and discharges to nursing homes grew from 7.3% to 10.7%. The incidence of mechanical ventilation is increasing, and the increase is associated with a higher burden of comorbidities and fewer discharges to home...
  65. ncbi Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients
    Francisco Manzano
    Intensive Care Unit, Virgen de las Nieves University Hospital, Granada, Spain
    Crit Care Med 36:2225-31. 2008
    ..To analyze the effect on clinical outcomes of prophylactic positive end expiratory pressure in nonhypoxemic ventilated patients...
  66. ncbi Effects of protective and conventional mechanical ventilation on pulmonary function and systemic cytokine release after cardiopulmonary bypass
    Ozge Koner
    Anesthesiology Department, Cardiology Institute, Istanbul University, Haseki caddesi, 34303, Aksaray Istanbul, Turkey
    Intensive Care Med 30:620-6. 2004
    ..To evaluate the effects of protective and conventional ventilation with or without positive end-expiratory pressure (PEEP), on systemic tumor necrosis factor-alpha, interleukin-6 levels and pulmonary function during open heart surgery...
  67. ncbi Pulse pressure variations to predict fluid responsiveness: influence of tidal volume
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital of the Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 31:517-23. 2005
    ..To evaluate the influence of tidal volume on the capacity of pulse pressure variation (DeltaPP) to predict fluid responsiveness...
  68. ncbi Passive leg raising predicts fluid responsiveness in the critically ill
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
    Crit Care Med 34:1402-7. 2006
    ..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
  69. ncbi Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia
    Shireesha Dhanireddy
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98103, USA
    Lab Invest 86:790-9. 2006
    ....
  70. ncbi Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injury
    Gilman B Allen
    Vermont Lung Center, Department of Medicine, University of Vermont, Fletcher Allen Health Care, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 291:L710-7. 2006
    ..Differences between LVDI and HV suggest that an optimal frequency range of DI exists, within which the benefits of maintaining an open lung outweigh injury incurred from overdistention...
  71. ncbi Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial
    Jean Claude Lacherade
    Medical Unit, Henri Mondor Hospital, Creteil, France
    Am J Respir Crit Care Med 172:1276-82. 2005
    ....
  72. pmc High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]
    Casper W Bollen
    Intensive Care, University Medical Centre Utrecht, The Netherlands
    Crit Care 9:R430-9. 2005
    ....
  73. ncbi Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure
    Davide Colombo
    Universita degli Studi del Piemonte Orientale A Avogadro, SCDU Anestesia, Terapia Intensiva e Rianimazione Generale, Azienda Ospedaliera Universitaria Maggiore Della Carità, Novara, Italy
    Intensive Care Med 34:2010-8. 2008
    ..We assessed the physiologic response to varying levels of NAVA and pressure support ventilation (PSV)...
  74. ncbi Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
    L B Ware
    Cardiovascular Research Institute, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Am J Respir Crit Care Med 163:1376-83. 2001
    ....
  75. ncbi Influence of airway management on ventilator-associated pneumonia: evidence from randomized trials
    D Cook
    Department of Medicine, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    JAMA 279:781-7. 1998
    ..Many interventions have been studied to reduce the risk of VAP. We systematically reviewed the influence of airway management on VAP in critically ill patients...
  76. pmc Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study
    Markus Zimmermann
    Department of Anesthesiology, University of Regensburg Medical Center, Regensburg, Germany
    Crit Care 13:R10. 2009
    ..In the present pilot study we tested the hypothesis that timely initiation of iLA using clear algorithms and an improved cannulation technique will positively influence complication rates and management of lung protective ventilation...
  77. ncbi Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  78. ncbi An update on bronchial blockers during lung separation techniques in adults
    Javier H Campos
    Department of Anesthesia, University of Iowa Health Care, Iowa City, Iowa 52242 1079, USA
    Anesth Analg 97:1266-74. 2003
    ..The current use of bronchial blockers, supported by scientific evidence, dictates that bronchial blockers should be available in any service that performs lung separation techniques...
  79. ncbi A prolonged postinspiratory pause enhances CO2 elimination by reducing airway dead space
    Leif Uttman
    Department of Clinical Physiology, University Hospital, Lund, Sweden
    Clin Physiol Funct Imaging 23:252-6. 2003
    ..The objective was to quantify changes in airway dead space (VDaw), slope of the alveolar plateau (SLOPE) and VCO2,T as a function of MDT in healthy pigs...
  80. pmc The new perilaryngeal airway (CobraPLA) is as efficient as the laryngeal mask airway (LMA) but provides better airway sealing pressures
    Ozan Akca
    Outcomes Research Institute, Louisville, Kentucky 40202, USA
    Anesth Analg 99:272-8. 2004
    ..Airway sealing pressure was significantly greater with CobraPLA (23 +/- 6 cm H2O) than LMA (18 +/- 5 cm H2O, P < 0.001). The CobraPLA has insertion characteristics similar to the LMA but better airway sealing capabilities...
  81. ncbi Impact of Gram-positive resistance on outcome of nosocomial pneumonia
    M Bodi
    Department of Critical Care, Hospital Universitari Joan XXIII, University Rovira i Virgili, Tarragona, Spain
    Crit Care Med 29:N82-6. 2001
    ..Optimizing treatment focusing on this goal and new antimicrobials provide new opportunities to improve survival. (Crit Care Med 2001; 29[Suppl.]:N82-N86)..
  82. ncbi Comparison of B-mode ultrasound and computed tomography in the diagnosis of maxillary sinusitis in mechanically ventilated patients
    G Hilbert
    Medical Intensive Care Unit, University Hospital of Bordeaux, Bordeaux, France
    Crit Care Med 29:1337-42. 2001
    ..CONCLUSION: B-mode ultrasound may be proposed first-line in a ventilated patient with suspicion of maxillary sinusitis...
  83. ncbi Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study
    D C Bergmans
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 164:382-8. 2001
    ..cross infection, prevention and control; respiration, artificial, adverse effects; antibiotics, administration and dosage infection control methods; pneumonia, etiology, prevention and control; intubation, intratracheal, adverse effects..
  84. ncbi Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    E W Ely
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
    JAMA 286:2703-10. 2001
    ..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
  85. ncbi Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm function
    Peter J Radell
    Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, 17176 Stockholm, Sweden
    Intensive Care Med 28:358-64. 2002
    ..This study used an animal model simulating the critical care environment to investigate the effects of 5 days' mechanical ventilation and inactivity on diaphragm contractility and neurophysiologic function...
  86. pmc Clinical review: severe asthma
    Spyros Papiris
    Department of Critical Care and Pulmonary Services, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece
    Crit Care 6:30-44. 2002
    ..Finally, after successful treatment and prior to discharge, a careful strategy for prevention of subsequent asthma attacks is imperative...
  87. pmc A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury
    Duane J Funk
    Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
    Respir Res 5:22. 2004
    ....
  88. ncbi Pre-ejection period variations predict the fluid responsiveness of septic ventilated patients
    Marc Feissel
    Intensive Care Unit, Centre Hospitalier, Belfort, France
    Crit Care Med 33:2534-9. 2005
    ..We hypothesized that the respiratory change in pre-ejection period (DeltaPEP) would allow the prediction of changes in cardiac index following volume administration in mechanically ventilated septic patients...
  89. ncbi The impact of delirium on the survival of mechanically ventilated patients
    Shu Min Lin
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Crit Care Med 32:2254-9. 2004
    ..To revalidate a means of assessing delirium in intensive care unit patients and to investigate the independent effect of delirium on the mortality of mechanically ventilated patients...
  90. ncbi First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unit
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, Regional University Centre, Lille, France
    Crit Care Med 33:283-9. 2005
    ..The objective of this study was to determine the relationship between fluoroquinolone (FQ) use and subsequent emergence of multiple drug-resistant bacteria (MRB) in the intensive care unit (ICU)...
  91. ncbi Effect of the mechanical ventilatory cycle on thermodilution right ventricular volumes and cardiac output
    A B Groeneveld
    Medical Intensive Care Unit, Institute for Cardiovascular Research, Free University Hospital, 1081 HV Amsterdam, The Netherlands
    J Appl Physiol (1985) 89:89-96. 2000
    ..We conclude that cyclic RV afterloading necessitates multiple thermodilution measurements equally spaced in the ventilatory cycle for reliable assessment of RV performance during mechanical ventilation of patients...
  92. ncbi The prognostic significance of passing a daily screen of weaning parameters
    E W Ely
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Intensive Care Med 25:581-7. 1999
    ..While "weaning parameters" are commonly used to guide removal of mechanical ventilation devices, little information exists concerning their prognostic value. We evaluated whether passing weaning parameters was associated with survival...
  93. ncbi The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 115:1076-84. 1999
    ..To evaluate the clinical utility of bronchoscopy with protected brush catheter (PBC) and BAL for patients with ventilator-associated pneumonia (VAP)...
  94. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  95. ncbi Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung
    Mariko Kotani
    Department of Anesthesiology, School of Medicine, Keio University, Japan
    Crit Care Med 32:514-9. 2004
    ..Acute lung injury induced by lung overstretch is associated with neutrophil influx, but the pathogenic role of neutrophils in overstretch-induced lung injury remains unclear...
  96. ncbi Indicators for tracheostomy in patients with traumatic brain injury
    Stan A Gurkin
    Division of Trauma and Critical Care, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am Surg 68:324-8; discussion 328-9. 2002
    ..Performing TR late did not reduce pneumonia rates or ventilator, ICU, or hospital days. By identifying the at-risk population early TR could be performed in an attempt to decrease morbidity and length of stay...
  97. ncbi Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome
    James Orme
    Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Respir Crit Care Med 167:690-4. 2003
    ..Acute respiratory distress syndrome survivors treated with high and low tidal volumes have abnormal pulmonary function that was related to decreased health-related quality of life 1 year after hospital discharge...
  98. ncbi Lung-protective ventilation strategies in acute lung injury
    Roy G Brower
    Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 31:S312-6. 2003
    ..To review the results of several randomized clinical trials of lung-protective ventilation strategies using conventional mechanical ventilators...
  99. ncbi Noninvasive cardiac output measurement using partial carbon dioxide rebreathing is less accurate at settings of reduced minute ventilation and when spontaneous breathing is present
    Kazuya Tachibana
    Surgical Intensive Care Unit, National Cardiovascular Center, Osaka, Japan
    Anesthesiology 98:830-7. 2003
    ..The objectives of the current study were to investigate whether tidal volume or minute ventilation is the dominant factor for the accuracy, and the accuracy of the technique when spontaneous breathing effort is present...
  100. ncbi Impact of low pulmonary vascular pressure on ventilator-induced lung injury
    Alain F Broccard
    Division of Intensive Care, Department of Medicine, University Hospital, Lausanne, Switzerland
    Crit Care Med 30:2183-90. 2002
    ..To study the impact of low pulmonary vascular pressure on ventilator-induced lung injury...
  101. ncbi ICU-acquired weakness
    William D Schweickert
    Pulmonary Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 6026, Chicago, IL 60657, USA
    Chest 131:1541-9. 2007
    ..We advocate an approach to this common syndrome that identifies risk factors early in the hope of minimizing their impact...

Research Grants145 found, 100 shown here

  1. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2009
    ..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
  2. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2007
    ..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
  3. DISCHARGE PATTERNS OF MOTONEURONS
    PEDRO RUDOMIN; Fiscal Year: 1990
    ..in anesthetized, decerebrated and decerebrated/spinal cats, either spontaneously or paralyzed and under artificial respiration. Particular attention will be given to: a), characterization of the intracellular PAD patterns produced by ..
  4. Measuring /Improving Quality of Life in Acute Lung Injury
    Christopher Cox; Fiscal Year: 2007
    ..These results will inform clinical trial outcomes measures as well as highlight targets for interventions designed to improve survivors' HRQL. ..
  5. Measuring /Improving Quality of Life in Acute Lung Injury
    Christopher Cox; Fiscal Year: 2008
    ..These results will inform clinical trial outcomes measures as well as highlight targets for interventions designed to improve survivors' HRQL. ..
  6. Impact of Cigarette Smoke Exposure on Acute Lung Injury
    CAROLYN CALFEE; Fiscal Year: 2008
    ..Therefore, studying the role of CSE in the development of ALI may help develop new therapies and will provide further rationale and support for measures to eliminate active and passive CSE. (End of Abstract) ..
  7. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2002
    ....
  8. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  9. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  10. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  11. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2006
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  12. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2003
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  13. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2008
    ..abstract_text> ..
  14. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2003
    ..abstract_text> ..
  15. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  16. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2002
    ....
  17. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  18. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2004
    ..abstract_text> ..
  19. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2007
    ..abstract_text> ..
  20. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2005
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  21. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  22. Weaning from Prolonged Mechanical Ventilation
    Amal Jubran; Fiscal Year: 2005
    ..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. ..
  23. Weaning from Prolonged Mechanical Ventilation
    Amal Jubran; Fiscal Year: 2006
    ..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. [unreadable] [unreadable]..
  24. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  25. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2005
    ..abstract_text> ..
  26. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  27. Weaning from Prolonged Mechanical Ventilation
    Amal Jubran; Fiscal Year: 2004
    ..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. ..
  28. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2007
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  29. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  30. Outcomes of Prolonged Mechanical Ventilation
    Shannon Carson; Fiscal Year: 2006
    ..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
  31. Weaning from Prolonged Mechanical Ventilation
    Amal Jubran; Fiscal Year: 2007
    ..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. [unreadable] [unreadable]..
  32. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  33. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2002
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  34. Sleep Depression, and Psychosocial Risk Factors in Caregivers
    Lisa Meltzer; Fiscal Year: 2008
    ..Approximately 8% of children have a chronic condition that transforms parents into caregivers. This 24-hour a day job often results in elevated symptoms of depression. ..
  35. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2000
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  36. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2000
    ....
  37. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2009
    ..abstract_text> ..
  38. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott Powers; Fiscal Year: 2009
    ..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
  39. Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network Trials
    Dale Needham; Fiscal Year: 2009
    ..End of Abstract) ..
  40. Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung Elastin
    Richard Bland; Fiscal Year: 2009
    ..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
  41. Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung Elastin
    RICHARD DAVID BLAND; Fiscal Year: 2010
    ..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
  42. Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network Trials
    DALE MURRAY contact NEEDHAM; Fiscal Year: 2010
    ..End of Abstract) ..
  43. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    SCOTT KLINE POWERS; Fiscal Year: 2010
    ..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
  44. Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network Trials
    Dale Needham; Fiscal Year: 2009
    ..End of Abstract) ..
  45. Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung Elastin
    Richard Bland; Fiscal Year: 2009
    ..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
  46. Mechanism of Traumatic Coagulopathy
    Mitchell Cohen; Fiscal Year: 2008
    ..Aim 3 entails dynamic modeling based on the results of Aim 1 and 2 data and as such is an interesting approach. The question is how will it be validated as reflective of what occurs in trauma patients? ..
  47. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2002
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  48. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2002
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  49. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2001
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  50. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2001
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  51. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2003
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  52. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2008
    ..abstract_text> ..
  53. Weaning from Prolonged Mechanical Ventilation
    Amal Jubran; Fiscal Year: 2008
    ..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. [unreadable] [unreadable]..
  54. Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network Trials
    Dale Needham; Fiscal Year: 2008
    ..End of Abstract) ..
  55. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2001
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  56. Incidence & management of hypotension in ill term & near-term infants in the NRN
    Kristi Watterberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Central Respiratory Effects of Organophosphate Poisoning
    Romolo Gaspari; Fiscal Year: 2007
    ..The goal of the applicant is to become an independent researcher in the area of neurophysiology and neurotoxicology with the ability to run his own laboratory and write successful grant applications. ..
  58. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2004
    ..Moreover, this technique should provide spinal cord injured patients the capacity to clear their secretions more readily and thereby reduce the incidence of respiratory complications and associated morbidity and mortality. ..
  59. Oxygen-Mediated Regulation of PDE5 in the Developing Pulmonary Vasculature
    KATHRYN FARROW; Fiscal Year: 2008
    ..End of Abstract) ..
  60. Palliation of Thirst in Intensive Care Unit Patients
    Kathleen Puntillo; Fiscal Year: 2009
    ..The study will also identify the most important factors that make ICU patients thirsty so that future research studies can test how to relieve those factors and/or make interventions for thirst more readily available. ..
  61. Executive Dysfunction and Functional Impairment in Elderly ICU Survivors
    James Jackson; Fiscal Year: 2008
    ....
  62. Palliation of Thirst in Intensive Care Unit Patients
    Kathleen A Puntillo; Fiscal Year: 2010
    ..The study will also identify the most important factors that make ICU patients thirsty so that future research studies can test how to relieve those factors and/or make interventions for thirst more readily available. ..
  63. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2006
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  64. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  65. Assessing and Treating Symptoms of Dying ICU Patients
    Kathleen Puntillo; Fiscal Year: 2006
    ..Results will also contribute empirical data needed to generate and test hypotheses concerning appropriate symptom assessment and management interventions. [unreadable] [unreadable] [unreadable]..
  66. Oxygen, Oxidant Stress and Wheezing in Premature Infants
    Timothy Stevens; Fiscal Year: 2008
    ..By evaluating the effect of oxygen exposure on oxidant stress and airway dysfunction this award will identify new therapeutic approaches to improve respiratory health of preterm infants in early childhood. ..
  67. Human genetic variation and ventricular fibrillation resuscitation outcomes
    Thomas Rea; Fiscal Year: 2008
    ..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..
  68. Strategies for Airway Management & Prevention Endotracheal Tube Cuff Intervention
    MARY SOLE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  69. Oxygen, Oxidant Stress and Wheezing in Premature Infants
    Timothy Stevens; Fiscal Year: 2007
    ..By evaluating the effect of oxygen exposure on oxidant stress and airway dysfunction this award will identify new therapeutic approaches to improve respiratory health of preterm infants in early childhood. ..
  70. Strategies for Airway Management & Prevention Endotracheal Tube Cuff Intervention
    MARY SOLE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  71. Assessing and Treating Symptoms of Dying ICU Patients
    Kathleen Puntillo; Fiscal Year: 2004
    ..Results will also contribute empirical data needed to generate and test hypotheses concerning appropriate symptom assessment and management interventions. ..
  72. LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1990
    ..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
  73. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    ..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..
  74. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    ....
  75. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2001
    ....
  76. LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1991
    ..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
  77. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2000
    ....
  78. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2005
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  79. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2005
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. ..
  80. Quality of Care and Outcomes of Healthcare-Associated Pneumonia
    Michael B Rothberg; Fiscal Year: 2010
    ..If recommended therapy is beneficial but underutilized, these results will alert quality improvement officers and policy makers to an important opportunity to improve patient care for a common and deadly illness. ..
  81. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2002
    ..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
  82. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    KURT ALBERTINE; Fiscal Year: 2001
    ....
  83. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2007
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  84. LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1992
    ..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
  85. LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1993
    ..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
  86. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
    ....
  87. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2001
    ..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
  88. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2002
    ....
  89. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2000
    ..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
  90. Human genetic variation and ventricular fibrillation resuscitation outcomes
    Thomas D Rea; Fiscal Year: 2010
    ..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..
  91. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2004
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. ..
  92. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2006
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  93. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2007
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..