Genomes and Genes
Summary: Any method of artifical breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2 ) and excretion of carbon dioxide (CO2 ).
Publications241 found, 100 shown here
- Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international studyAndres Esteban
Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
JAMA 287:345-55. 2002..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
- Efficacy and safety of corticosteroids for persistent acute respiratory distress syndromeKenneth P Steinberg
Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
N Engl J Med 354:1671-84. 2006..Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS...
- Clinical and economic consequences of ventilator-associated pneumonia: a systematic reviewNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Crit Care Med 33:2184-93. 2005..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature..
- The respiratory variation in inferior vena cava diameter as a guide to fluid therapyMarc Feissel
Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
Intensive Care Med 30:1834-7. 2004..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
- Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental NetworkL J Van Marter
Children s Hospital, Boston, Massachusetts 02115, USA
Pediatrics 105:1194-201. 2000..To explore the hypothesis that variation in respiratory management among newborn intensive care units (NICUs) explains differences in chronic lung disease (CLD) rates...
- What tidal volumes should be used in patients without acute lung injury?Marcus J Schultz
Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
Anesthesiology 106:1226-31. 2007..Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI...
- Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patientsDaniel A Reuter
Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Intensive Care Med 29:476-80. 2003..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
- Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unitArmando J Rotondi
University of Pittsburgh, Pittsburgh, PA
Crit Care Med 30:746-52. 2002..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
- Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart diseaseTimothy F Feltes
Ohio State University and The Children s Hospital, 700 Children s Drive, ED622, Columbus, OH 43205, USA
J Pediatr 143:532-40. 2003..To evaluate the safety, tolerance, and efficacy of palivizumab in children with hemodynamically significant congenital heart disease (CHD)...
- Pulmonary contusion: review of the clinical entityS M Cohn
Section of Trauma and Surgical Critical Care, Yale University School of Medicine, New Haven, Connecticut, USA
J Trauma 42:973-9. 1997..Although management of patients with pulmonary contusion is supportive, pneumonia and adult respiratory distress syndrome with long-term disability occur frequently...
- Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitionsNiall D Ferguson
Interdepartmental Division of Critical Care Medicine and the Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Crit Care Med 33:2228-34. 2005..A second objective was to determine the accuracy of clinical diagnoses of ARDS made in daily practice...
- Recruitment and derecruitment during acute respiratory failure: an experimental studyP Pelosi
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:122-30. 2001..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
- Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failureG Hilbert
Division of Medical Intensive Care, University Hospital, Bordeaux, France
N Engl J Med 344:481-7. 2001..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
- Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injuryAnne Le
Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Appl Physiol (1985) 105:1282-90. 2008....
- Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infantsLinda J Van Marter
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Pediatr 140:171-6. 2002..This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection...
- Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilationSeok Mo Heo
Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
Clin Infect Dis 47:1562-70. 2008....
- Oxygenation index predicts outcome in children with acute hypoxemic respiratory failureDaniel Trachsel
Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
Am J Respir Crit Care Med 172:206-11. 2005..This is best reflected by the OI, which shows a direct correlation to outcome in a time-independent manner...
- The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patientsCurtis N Sessler
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
Am J Respir Crit Care Med 166:1338-44. 2002..Our nurses described RASS as logical, easy to administer, and readily recalled. RASS has high reliability and validity in medical and surgical, ventilated and nonventilated, and sedated and nonsedated adult ICU patients...
- Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patientsChristophe Barbier
Medical and Surgical Intensive Care Unit, Hospital St Germain en Laye, 20 rue Armagis, 78100 St Germain en Laye, France
Intensive Care Med 30:1740-6. 2004..To evaluate the extent to which respiratory changes in inferior vena cava (IVC) diameter can be used to predict fluid responsiveness...
- Comparison of two fluid-management strategies in acute lung injuryHerbert P Wiedemann
Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
N Engl J Med 354:2564-75. 2006..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
- Difficult Airway Society guidelines for management of the unanticipated difficult intubationJ J Henderson
Anaesthetic Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK
Anaesthesia 59:675-94. 2004..Disclaimer: It is not intended that these guidelines should constitute a minimum standard of practice, nor are they to be regarded as a substitute for good clinical judgement...
- Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injuryEsther K Wolthuis
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Anesthesiology 108:46-54. 2008..The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury...
- Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsisG Marx
University of Liverpool, University Department of Anaesthesia, Liverpool, UK
Eur J Anaesthesiol 21:132-8. 2004..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
- Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trialV M Ranieri
Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
JAMA 282:54-61. 1999....
- Evolution of mechanical ventilation in response to clinical researchAndres Esteban
Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
Am J Respir Crit Care Med 177:170-7. 2008..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...
- Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosaAlan R Hauser
Department of Microbiology Immunology, Northwestern University, Chicago, IL, USA
Crit Care Med 30:521-8. 2002..The objective of this study was to determine whether this system contributes to disease severity in humans with ventilator-associated pneumonia...
- The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgeryHermann Wrigge
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
Anesth Analg 98:775-81, table of contents. 2004..Our data suggest that the ventilatory settings we studied do not affect inflammatory reactions during major surgery within 3 h...
- Superior vena caval collapsibility as a gauge of volume status in ventilated septic patientsAntoine Vieillard-Baron
Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France
Intensive Care Med 30:1734-9. 2004..We tested the hypothesis that measurement of superior vena caval collapsibility would reveal the need for volume expansion in a given septic patient...
- Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy miceEsther K Wolthuis
Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
Crit Care 13:R1. 2009..To study VILI in healthy mice, the authors used a MV model with clinically relevant ventilator settings, avoiding massive damage of lung structures and shock, and preventing metabolic acidosis...
- Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trialG Umberto Meduri
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
Chest 131:954-63. 2007..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
- Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavageJames E Baumgardner
Department of Anesthesia, School of Veterinary Medicine, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia 19104 4283, USA
Am J Respir Crit Care Med 166:1556-62. 2002..The important effect of RR on the magnitude of PaO2 oscillations suggests that the static behavior of atelectasis cannot be accurately extrapolated to predict dynamic behavior at realistic breathing frequencies...
- Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcomeCarlos M Luna
Pulmonary and Critical Care Divisions, Department of Medicine, Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Argentina
Crit Care Med 31:676-82. 2003..To prospectively evaluate the performance of the Clinical Pulmonary Infection Score (CPIS) and its components to identify early in the hospital course of ventilator-associated pneumonia (VAP) which patients are responding to therapy...
- Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical centerDavid K Warren
Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
Crit Care Med 31:1312-7. 2003..To determine the attributable cost of ventilator-associated pneumonia from a hospital-based cost perspective, after adjusting for potential confounders...
- The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patientsCyril Charron
Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
Anesth Analg 102:1511-7. 2006..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
- Postnatal risk factors of retinopathy of prematurityTae Im Kim
Department of Ophthalmology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea
Paediatr Perinat Epidemiol 18:130-4. 2004..In addition, apnoea may not only increase the risk of developing ROP, but may also worsen pre-existing ROP...
- Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trialTimothy D Girard
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
Lancet 371:126-34. 2008..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
- [Diagnostic value of quantitative cultures of endotracheal aspirate in ventilator-associated pneumonia: a multicenter study]M Valencia Arango
Unidad de Cuidados Intensivos Universidad Pontificia Bolivariana Medellín Colombia, and Hospital Clínic Barcelona España
Arch Bronconeumol 39:394-9. 2003..To study the validity of quantitative cultures of tracheal aspirate (TA) in comparison with the plugged telescoping catheter (PTC) for the diagnosis of mechanical ventilator-associated pneumonia...
- Device-associated, device-day infection rates in an Israeli adult general intensive care unitR Finkelstein
Infectious Diseases Unit, Rambam Medical Center Technion Israel Institute of Technology, Faculty of Medicine Haifa, Israel
J Hosp Infect 44:200-5. 2000..The present study provides specific surveillance data for further interhospital comparison with similar types of ICUs...
- Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humansSanford Levine
Department of Surgery, University of Pennsylvania, USA
N Engl J Med 358:1327-35. 2008..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm...
- Outcomes of adults hospitalised with severe influenzaN Lee
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
Thorax 65:510-5. 2010..The aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza...
- Chorioamnionitis alters the response to surfactant in preterm infantsJasper V Been
Department of Paediatrics, School for Oncology and Developmental Biology GROW, Maastricht University Medical Centre, Maastricht, The Netherlands
J Pediatr 156:10-15.e1. 2010..To study the association between antenatal exposure to chorioamnionitis and the neonatal response to surfactant...
- Early intervention can improve clinical outcome of acute interstitial pneumoniaGee Young Suh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
Chest 129:753-61. 2006....
- Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumoniaP J Dennesen
Department of Medical Microbiology, Medical Technology Assessment and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
Am J Respir Crit Care Med 163:1371-5. 2001....
- Ventilator-induced cell wounding and repair in the intact lungOgnjen Gajic
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Respir Crit Care Med 167:1057-63. 2003..25 +/- 0.09 to 0.08 +/- 0.08, p < 0.01). We conclude that cells of ventilator-injured lungs are subject to reversible plasma membrane stress failure...
- Is there a safe plateau pressure in ARDS? The right heart only knowsFrancois Jardin
Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, France
Intensive Care Med 33:444-7. 2007..The objective of the present study was to examine if the echocardiographic evaluation of right ventricular function performed in ARDS may help to answer to this question...
- Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head traumaPhilippe Seguin
Surgical Intensive Care Unit, INSERM U620, Hopital Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
Crit Care Med 34:1514-9. 2006..To evaluate the effect of a regular oropharyngeal application of povidone-iodine on the prevalence of ventilator-associated pneumonia in patients with severe head trauma...
- Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndromeMarc Gainnier
Service de Reanimation Medicale, hopitaux Sud, Marseille, France
Crit Care Med 32:113-9. 2004..To evaluate the effects of a 48-hr neuromuscular blocking agents (NMBA) infusion on gas exchange over a 120-hr time period in patients with acute respiratory distress syndrome...
- ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimensDaniel L Herr
Washington Hospital Center, Washington, DC 2010, USA
J Cardiothorac Vasc Anesth 17:576-84. 2003..To compare dexmedetomidine-based to propofol-based sedation after coronary artery bypass graft (CABG) surgery in the intensive care unit (ICU)...
- Outcomes after long-term acute care. An analysis of 133 mechanically ventilated patientsS S Carson
Departments of Medicine, Robert Wood Johnson Clinical Scholars Program, University of Chicago, Chicago, Illinois, USA
Am J Respir Crit Care Med 159:1568-73. 1999..001). We demonstrate characteristics predicting the poorest prognoses for patients requiring prolonged mechanical ventilation. These characteristics may be identifiable before transfer to an LTAC hospital...
- Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulationErcole Zanotti
Pulmonary Department, Scientific Institute of Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Italy
Chest 124:292-6. 2003....
- Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysisJosep Masip
ICU Department, Hospital Dos de Maig Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain
JAMA 294:3124-30. 2005..In patients with acute cardiogenic pulmonary edema noninvasive ventilation may reduce intubation rate, but the impact on mortality and the superiority of one technique over another have not been clearly established...
- Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgeryDaniel A Reuter
Department of Anesthesiology, Grosshadern University Hospital, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Intensive Care Med 28:392-8. 2002....
- A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patientsMark J Rumbak
Department of Medicine, Division of Pulmonary, Critical Care and Occupation Medicine, Tampa General Hospital University of South Florida Health Science Center, Tampa, FL 33612, USA
Crit Care Med 32:1689-94. 2004..The effects of early percutaneous dilational tracheotomy compared with delayed tracheotomy in critically ill medical patients needing prolonged mechanical ventilation were assessed...
- High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenationDidier Demory
Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
Crit Care Med 35:106-11. 2007..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
- Ventilator-associated pneumoniaJean Chastre
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
Am J Respir Crit Care Med 165:867-903. 2002..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
- Readmission rates and life threatening events in COPD survivors treated with non-invasive ventilation for acute hypercapnic respiratory failureC M Chu
Division of Respiratory Medicine, Department of Medicine and Geriatrics, United Christian Hospital, Kowloon, Hong Kong, SAR, China
Thorax 59:1020-5. 2004..However, little information exists on the outcomes following discharge. A study was undertaken to examine the rates of readmission, recurrent AHRF, and death following discharge and the risk factors associated with them...
- Acute respiratory distress syndromeSusannah K Leaver
Department of Critical Care, Imperial College School of Medicine, Royal Brompton Hospital, London SW3 6NP
BMJ 335:389-94. 2007
- Early changes in lung gene expression due to high tidal volumeIan B Copland
Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 168:1051-9. 2003..the effects of HV are cumulative; (2). specific patterns of gene activation and suppression precede lung injury; and (3). alteration of gene expression after mechanical stretch is pathogenic...
- Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy ratsAndrea Moriondo
Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Universita degli Studi dell Insubria, via J H Dunant 5, 21100 Varese, Italy
J Appl Physiol 103:747-56. 2007....
- A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patientsB D Freeman
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
Crit Care Med 29:926-30. 2001..PDT may become the procedure of choice for electively establishing tracheostomy in the appropriately selected patient who requires long-term mechanical ventilation...
- Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotensionB Tavernier
Department of Anesthesia 2, University Hospital, Lille, France
Anesthesiology 89:1313-21. 1998....
- Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injuryTamas Dolinay
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
PLoS ONE 3:e1601. 2008....
- Is it safer to intubate premature infants in the delivery room?Hany Aly
Department of Newborn Services, George Washington University Hospital, Washington, DC 20037, USA
Pediatrics 115:1660-5. 2005..We also explored potential harmful effects of early intubation and examined whether unsuccessful ENCPAP attempts might subject infants to any unforeseen morbidity...
- The changing epidemiology of mechanical ventilation: a population-based studyShannon S Carson
Department of Medicine and the Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7020, USA
J Intensive Care Med 21:173-82. 2006..4% to 34.4%, and discharges to nursing homes grew from 7.3% to 10.7%. The incidence of mechanical ventilation is increasing, and the increase is associated with a higher burden of comorbidities and fewer discharges to home...
- Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patientsFrancisco Manzano
Intensive Care Unit, Virgen de las Nieves University Hospital, Granada, Spain
Crit Care Med 36:2225-31. 2008..To analyze the effect on clinical outcomes of prophylactic positive end expiratory pressure in nonhypoxemic ventilated patients...
- Effects of protective and conventional mechanical ventilation on pulmonary function and systemic cytokine release after cardiopulmonary bypassOzge Koner
Anesthesiology Department, Cardiology Institute, Istanbul University, Haseki caddesi, 34303, Aksaray Istanbul, Turkey
Intensive Care Med 30:620-6. 2004..To evaluate the effects of protective and conventional ventilation with or without positive end-expiratory pressure (PEEP), on systemic tumor necrosis factor-alpha, interleukin-6 levels and pulmonary function during open heart surgery...
- Pulse pressure variations to predict fluid responsiveness: influence of tidal volumeDaniel De Backer
Department of Intensive Care, Erasme University Hospital of the Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
Intensive Care Med 31:517-23. 2005..To evaluate the influence of tidal volume on the capacity of pulse pressure variation (DeltaPP) to predict fluid responsiveness...
- Passive leg raising predicts fluid responsiveness in the critically illXavier Monnet
Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
Crit Care Med 34:1402-7. 2006..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
- Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumoniaShireesha Dhanireddy
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98103, USA
Lab Invest 86:790-9. 2006....
- Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injuryGilman B Allen
Vermont Lung Center, Department of Medicine, University of Vermont, Fletcher Allen Health Care, Burlington, VT 05405, USA
Am J Physiol Lung Cell Mol Physiol 291:L710-7. 2006..Differences between LVDI and HV suggest that an optimal frequency range of DI exists, within which the benefits of maintaining an open lung outweigh injury incurred from overdistention...
- Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trialJean Claude Lacherade
Medical Unit, Henri Mondor Hospital, Creteil, France
Am J Respir Crit Care Med 172:1276-82. 2005....
- High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]Casper W Bollen
Intensive Care, University Medical Centre Utrecht, The Netherlands
Crit Care 9:R430-9. 2005....
- Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failureDavide Colombo
Universita degli Studi del Piemonte Orientale A Avogadro, SCDU Anestesia, Terapia Intensiva e Rianimazione Generale, Azienda Ospedaliera Universitaria Maggiore Della Carità, Novara, Italy
Intensive Care Med 34:2010-8. 2008..We assessed the physiologic response to varying levels of NAVA and pressure support ventilation (PSV)...
- Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndromeL B Ware
Cardiovascular Research Institute, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
Am J Respir Crit Care Med 163:1376-83. 2001....
- Influence of airway management on ventilator-associated pneumonia: evidence from randomized trialsD Cook
Department of Medicine, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
JAMA 279:781-7. 1998..Many interventions have been studied to reduce the risk of VAP. We systematically reviewed the influence of airway management on VAP in critically ill patients...
- Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot studyMarkus Zimmermann
Department of Anesthesiology, University of Regensburg Medical Center, Regensburg, Germany
Crit Care 13:R10. 2009..In the present pilot study we tested the hypothesis that timely initiation of iLA using clear algorithms and an improved cannulation technique will positively influence complication rates and management of lung protective ventilation...
- Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trialPratik P Pandharipande
Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
JAMA 298:2644-53. 2007..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
- An update on bronchial blockers during lung separation techniques in adultsJavier H Campos
Department of Anesthesia, University of Iowa Health Care, Iowa City, Iowa 52242 1079, USA
Anesth Analg 97:1266-74. 2003..The current use of bronchial blockers, supported by scientific evidence, dictates that bronchial blockers should be available in any service that performs lung separation techniques...
- A prolonged postinspiratory pause enhances CO2 elimination by reducing airway dead spaceLeif Uttman
Department of Clinical Physiology, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 23:252-6. 2003..The objective was to quantify changes in airway dead space (VDaw), slope of the alveolar plateau (SLOPE) and VCO2,T as a function of MDT in healthy pigs...
- The new perilaryngeal airway (CobraPLA) is as efficient as the laryngeal mask airway (LMA) but provides better airway sealing pressuresOzan Akca
Outcomes Research Institute, Louisville, Kentucky 40202, USA
Anesth Analg 99:272-8. 2004..Airway sealing pressure was significantly greater with CobraPLA (23 +/- 6 cm H2O) than LMA (18 +/- 5 cm H2O, P < 0.001). The CobraPLA has insertion characteristics similar to the LMA but better airway sealing capabilities...
- Impact of Gram-positive resistance on outcome of nosocomial pneumoniaM Bodi
Department of Critical Care, Hospital Universitari Joan XXIII, University Rovira i Virgili, Tarragona, Spain
Crit Care Med 29:N82-6. 2001..Optimizing treatment focusing on this goal and new antimicrobials provide new opportunities to improve survival. (Crit Care Med 2001; 29[Suppl.]:N82-N86)..
- Comparison of B-mode ultrasound and computed tomography in the diagnosis of maxillary sinusitis in mechanically ventilated patientsG Hilbert
Medical Intensive Care Unit, University Hospital of Bordeaux, Bordeaux, France
Crit Care Med 29:1337-42. 2001..CONCLUSION: B-mode ultrasound may be proposed first-line in a ventilated patient with suspicion of maxillary sinusitis...
- Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled studyD C Bergmans
Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
Am J Respir Crit Care Med 164:382-8. 2001..cross infection, prevention and control; respiration, artificial, adverse effects; antibiotics, administration and dosage infection control methods; pneumonia, etiology, prevention and control; intubation, intratracheal, adverse effects..
- Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)E W Ely
Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
JAMA 286:2703-10. 2001..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
- Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm functionPeter J Radell
Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, 17176 Stockholm, Sweden
Intensive Care Med 28:358-64. 2002..This study used an animal model simulating the critical care environment to investigate the effects of 5 days' mechanical ventilation and inactivity on diaphragm contractility and neurophysiologic function...
- Clinical review: severe asthmaSpyros Papiris
Department of Critical Care and Pulmonary Services, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece
Crit Care 6:30-44. 2002..Finally, after successful treatment and prior to discharge, a careful strategy for prevention of subsequent asthma attacks is imperative...
- A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injuryDuane J Funk
Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
Respir Res 5:22. 2004....
- Pre-ejection period variations predict the fluid responsiveness of septic ventilated patientsMarc Feissel
Intensive Care Unit, Centre Hospitalier, Belfort, France
Crit Care Med 33:2534-9. 2005..We hypothesized that the respiratory change in pre-ejection period (DeltaPEP) would allow the prediction of changes in cardiac index following volume administration in mechanically ventilated septic patients...
- The impact of delirium on the survival of mechanically ventilated patientsShu Min Lin
Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
Crit Care Med 32:2254-9. 2004..To revalidate a means of assessing delirium in intensive care unit patients and to investigate the independent effect of delirium on the mortality of mechanically ventilated patients...
- First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unitSaad Nseir
Intensive Care Unit, Calmette Hospital, Regional University Centre, Lille, France
Crit Care Med 33:283-9. 2005..The objective of this study was to determine the relationship between fluoroquinolone (FQ) use and subsequent emergence of multiple drug-resistant bacteria (MRB) in the intensive care unit (ICU)...
- Effect of the mechanical ventilatory cycle on thermodilution right ventricular volumes and cardiac outputA B Groeneveld
Medical Intensive Care Unit, Institute for Cardiovascular Research, Free University Hospital, 1081 HV Amsterdam, The Netherlands
J Appl Physiol (1985) 89:89-96. 2000..We conclude that cyclic RV afterloading necessitates multiple thermodilution measurements equally spaced in the ventilatory cycle for reliable assessment of RV performance during mechanical ventilation of patients...
- The prognostic significance of passing a daily screen of weaning parametersE W Ely
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Intensive Care Med 25:581-7. 1999..While "weaning parameters" are commonly used to guide removal of mechanical ventilation devices, little information exists concerning their prognostic value. We evaluated whether passing weaning parameters was associated with survival...
- The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials GroupD K Heyland
Department of Medicine, Queen s University, Kingston, Ontario, Canada
Chest 115:1076-84. 1999..To evaluate the clinical utility of bronchoscopy with protected brush catheter (PBC) and BAL for patients with ventilator-associated pneumonia (VAP)...
- Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trialRichard R Riker
University of Vermont College of Medicine, USA
JAMA 301:489-99. 2009..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
- Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lungMariko Kotani
Department of Anesthesiology, School of Medicine, Keio University, Japan
Crit Care Med 32:514-9. 2004..Acute lung injury induced by lung overstretch is associated with neutrophil influx, but the pathogenic role of neutrophils in overstretch-induced lung injury remains unclear...
- Indicators for tracheostomy in patients with traumatic brain injuryStan A Gurkin
Division of Trauma and Critical Care, Henry Ford Hospital, Detroit, Michigan 48202, USA
Am Surg 68:324-8; discussion 328-9. 2002..Performing TR late did not reduce pneumonia rates or ventilator, ICU, or hospital days. By identifying the at-risk population early TR could be performed in an attempt to decrease morbidity and length of stay...
- Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndromeJames Orme
Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah 84143, USA
Am J Respir Crit Care Med 167:690-4. 2003..Acute respiratory distress syndrome survivors treated with high and low tidal volumes have abnormal pulmonary function that was related to decreased health-related quality of life 1 year after hospital discharge...
- Lung-protective ventilation strategies in acute lung injuryRoy G Brower
Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 31:S312-6. 2003..To review the results of several randomized clinical trials of lung-protective ventilation strategies using conventional mechanical ventilators...
- Noninvasive cardiac output measurement using partial carbon dioxide rebreathing is less accurate at settings of reduced minute ventilation and when spontaneous breathing is presentKazuya Tachibana
Surgical Intensive Care Unit, National Cardiovascular Center, Osaka, Japan
Anesthesiology 98:830-7. 2003..The objectives of the current study were to investigate whether tidal volume or minute ventilation is the dominant factor for the accuracy, and the accuracy of the technique when spontaneous breathing effort is present...
- Impact of low pulmonary vascular pressure on ventilator-induced lung injuryAlain F Broccard
Division of Intensive Care, Department of Medicine, University Hospital, Lausanne, Switzerland
Crit Care Med 30:2183-90. 2002..To study the impact of low pulmonary vascular pressure on ventilator-induced lung injury...
- ICU-acquired weaknessWilliam D Schweickert
Pulmonary Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 6026, Chicago, IL 60657, USA
Chest 131:1541-9. 2007..We advocate an approach to this common syndrome that identifies risk factors early in the hope of minimizing their impact...
Research Grants145 found, 100 shown here
- Development of a Photoactivated Respiratory Support DeviceRichard Gilbert; Fiscal Year: 2009..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
- Development of a Photoactivated Respiratory Support DeviceRichard Gilbert; Fiscal Year: 2007..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
- Measuring /Improving Quality of Life in Acute Lung InjuryChristopher Cox; Fiscal Year: 2007..These results will inform clinical trial outcomes measures as well as highlight targets for interventions designed to improve survivors' HRQL. ..
- DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTSJudith Rabkin; Fiscal Year: 2003..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
- MECHANICAL VENTILATION AND RESPIRATORY MUSCLESScott Powers; Fiscal Year: 2004..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
- CHRONIC LUNG INJURY AFTER PREMATURE BIRTHRichard Bland; Fiscal Year: 2003....
- Mechanical Ventilation and Diaphragmatic Oxidant InjuryScott Powers; Fiscal Year: 2007..abstract_text> ..
- Exercise, Antioxidants, and I-R InjuryScott Powers; Fiscal Year: 2006..abstract_text> ..
- Aerosolized PGE1 in Neonatal Pulmonary HypertensionBEENA SOOD; Fiscal Year: 2005..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
- Modafinil Treatment for Fatigue in HIV+ PatientsJudith Rabkin; Fiscal Year: 2007..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
- Reducing Sedative Exposure in Ventilated ICU PatientsLinda Chlan; Fiscal Year: 2007....
- Outcomes of Prolonged Mechanical VentilationShannon Carson; Fiscal Year: 2006..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
- Weaning from Prolonged Mechanical VentilationAmal Jubran; Fiscal Year: 2007..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. ..
- DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMESJudith Rabkin; Fiscal Year: 2004..The data collected in the preliminary study will be used in the full-scale study. ..
- Reducing Sedative Exposure in Ventilated ICU PatientsLinda Chlan; Fiscal Year: 2009..abstract_text> ..
- Mechanical ventilation, oxidative stress, and diaphragmatic atrophyScott Powers; Fiscal Year: 2009..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDale Needham; Fiscal Year: 2009..End of Abstract) ..
- Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinRichard Bland; Fiscal Year: 2009..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
- Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinRICHARD DAVID BLAND; Fiscal Year: 2010..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDALE MURRAY contact NEEDHAM; Fiscal Year: 2010..End of Abstract) ..
- Mechanical ventilation, oxidative stress, and diaphragmatic atrophySCOTT KLINE POWERS; Fiscal Year: 2010..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDale Needham; Fiscal Year: 2009..End of Abstract) ..
- Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinRichard Bland; Fiscal Year: 2009..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
- Central Respiratory Effects of Organophosphate PoisoningRomolo Gaspari; Fiscal Year: 2007..The goal of the applicant is to become an independent researcher in the area of neurophysiology and neurotoxicology with the ability to run his own laboratory and write successful grant applications. ..
- Palliation of Thirst in Intensive Care Unit PatientsKathleen Puntillo; Fiscal Year: 2009..The study will also identify the most important factors that make ICU patients thirsty so that future research studies can test how to relieve those factors and/or make interventions for thirst more readily available. ..
- Palliation of Thirst in Intensive Care Unit PatientsKathleen A Puntillo; Fiscal Year: 2010..The study will also identify the most important factors that make ICU patients thirsty so that future research studies can test how to relieve those factors and/or make interventions for thirst more readily available. ..
- Stretch and Vitamin A Effects on Alveolar FormationKURT ALBERTINE; Fiscal Year: 2009..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
- Assessing and Treating Symptoms of Dying ICU PatientsKathleen Puntillo; Fiscal Year: 2006..Results will also contribute empirical data needed to generate and test hypotheses concerning appropriate symptom assessment and management interventions. ..
- Strategies for Airway Management & Prevention Endotracheal Tube Cuff InterventionMARY SOLE; Fiscal Year: 2007..Findings will assist in designing airway management interventions and technologies to improve the outcomes of critically ill patients, and inform the development of an intervention/technology package to reduce VAP. ..
- Oxygen, Oxidant Stress and Wheezing in Premature InfantsTimothy Stevens; Fiscal Year: 2007..By evaluating the effect of oxygen exposure on oxidant stress and airway dysfunction this award will identify new therapeutic approaches to improve respiratory health of preterm infants in early childhood. ..
- LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 1999..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..
- Quality of Care and Outcomes of Healthcare-Associated PneumoniaMichael B Rothberg; Fiscal Year: 2010..If recommended therapy is beneficial but underutilized, these results will alert quality improvement officers and policy makers to an important opportunity to improve patient care for a common and deadly illness. ..
- VITAMIN A EFFECTS ON ALVEOLAR FORMATIONKURT ALBERTINE; Fiscal Year: 2002..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
- CHRONIC LUNG INJURY AFTER PREMATURE BIRTHKURT ALBERTINE; Fiscal Year: 2001....
- Home Automatic external Defibrillator TrainingThomas Rea; Fiscal Year: 2007..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. ..
- LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 1993..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
- LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 2003....
- Human genetic variation and ventricular fibrillation resuscitation outcomesThomas D Rea; Fiscal Year: 2010..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..