Genomes and Genes
Summary: Any method of artifical breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2 ) and excretion of carbon dioxide (CO2 ).
Publications189 found, 100 shown here
- Clinical and economic consequences of ventilator-associated pneumonia: a systematic reviewNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Crit Care Med 33:2184-93. 2005..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature..
- Ventilator-associated pneumoniaJean Chastre
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
Am J Respir Crit Care Med 165:867-903. 2002..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
- Pulmonary contusion: review of the clinical entityS M Cohn
Section of Trauma and Surgical Critical Care, Yale University School of Medicine, New Haven, Connecticut, USA
J Trauma 42:973-9. 1997..Although management of patients with pulmonary contusion is supportive, pneumonia and adult respiratory distress syndrome with long-term disability occur frequently...
- Comparison of two fluid-management strategies in acute lung injuryHerbert P Wiedemann
Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
N Engl J Med 354:2564-75. 2006..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
- Superior vena caval collapsibility as a gauge of volume status in ventilated septic patientsAntoine Vieillard-Baron
Medical Intensive Care Unit, University Hospital Ambroise Par, , 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France
Intensive Care Med 30:1734-9. 2004..CONCLUSIONS: Superior vena cava measurement should be systematically performed during routine echocardiography in septic shock as it gives an accurate index of fluid responsiveness...
- Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy miceEsther K Wolthuis
Department of Intensive Care Medicine, University of Amsterdam, Amsterdam, The Netherlands
Crit Care 13:R1. 2009..To study VILI in healthy mice, the authors used a MV model with clinically relevant ventilator settings, avoiding massive damage of lung structures and shock, and preventing metabolic acidosis...
- The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgeryHermann Wrigge
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
Anesth Analg 98:775-81, table of contents. 2004..Our data suggest that the ventilatory settings we studied do not affect inflammatory reactions during major surgery within 3 h...
- Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trialG Umberto Meduri
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
Chest 131:954-63. 2007..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
- Outcomes of adults hospitalised with severe influenzaN Lee
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
Thorax 65:510-5. 2010..The aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza...
- Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosaAlan R Hauser
Department of Microbiology/Immunology, Northwestern University, Chicago, IL, USA
Crit Care Med 30:521-8. 2002..Our findings support the hypothesis that antibodies targeted against these proteins may be useful as adjunctive therapy in intubated patients with P. aeruginosa colonization or infection...
- Is there a safe plateau pressure in ARDS? The right heart only knowsFrancois Jardin
Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, France
Intensive Care Med 33:444-7. 2007..The objective of the present study was to examine if the echocardiographic evaluation of right ventricular function performed in ARDS may help to answer to this question...
- Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head traumaPhilippe Seguin
Surgical Intensive Care Unit, INSERM U620, , 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
Crit Care Med 34:1514-9. 2006..CONCLUSIONS: The regular administration of povidone-iodine may be an effective strategy for decreasing the prevalence of ventilator-associated pneumonia in patients with severe head trauma...
- Ventilator-induced cell wounding and repair in the intact lungOgnjen Gajic
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Respir Crit Care Med 167:1057-63. 2003..25 +/- 0.09 to 0.08 +/- 0.08, p < 0.01). We conclude that cells of ventilator-injured lungs are subject to reversible plasma membrane stress failure...
- Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injuryEsther K Wolthuis
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Anesthesiology 108:46-54. 2008..The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury...
- Readmission rates and life threatening events in COPD survivors treated with non-invasive ventilation for acute hypercapnic respiratory failureC M Chu
Division of Respiratory Medicine, Department of Medicine and Geriatrics, United Christian Hospital, Kowloon, Hong Kong, SAR, China
Thorax 59:1020-5. 2004..However, little information exists on the outcomes following discharge. A study was undertaken to examine the rates of readmission, recurrent AHRF, and death following discharge and the risk factors associated with them...
- Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy ratsAndrea Moriondo
Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Universita degli Studi dell Insubria, via J H Dunant 5, 21100 Varese, Italy
J Appl Physiol 103:747-56. 2007....
- Difficult Airway Society guidelines for management of the unanticipated difficult intubationJ J Henderson
Anaesthetic Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK
Anaesthesia 59:675-94. 2004..Disclaimer: It is not intended that these guidelines should constitute a minimum standard of practice, nor are they to be regarded as a substitute for good clinical judgement...
- Acute respiratory distress syndromeSusannah K Leaver
Department of Critical Care, Imperial College School of Medicine, Royal Brompton Hospital, London SW3 6NP
BMJ 335:389-94. 2007
- Early changes in lung gene expression due to high tidal volumeIan B Copland
Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 168:1051-9. 2003..the effects of HV are cumulative; (2). specific patterns of gene activation and suppression precede lung injury; and (3). alteration of gene expression after mechanical stretch is pathogenic...
- Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trialPratik P Pandharipande
Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
JAMA 298:2644-53. 2007..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
- High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]Casper W Bollen
Intensive Care, University Medical Centre Utrecht, The Netherlands
Crit Care 9:R430-9. 2005....
- Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injuryGilman B Allen
Vermont Lung Center, Department of Medicine, University of Vermont, Fletcher Allen Health Care, Burlington, VT 05405, USA
Am J Physiol Lung Cell Mol Physiol 291:L710-7. 2006..Differences between LVDI and HV suggest that an optimal frequency range of DI exists, within which the benefits of maintaining an open lung outweigh injury incurred from overdistention...
- Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infantsLinda J Van Marter
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Pediatr 140:171-6. 2002....
- Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failureDavide Colombo
Universita degli Studi del Piemonte Orientale A Avogadro, SCDU Anestesia, Terapia Intensiva e Rianimazione Generale, Azienda Ospedaliera Universitaria Maggiore Della Carità, Novara, Italy
Intensive Care Med 34:2010-8. 2008..We assessed the physiologic response to varying levels of NAVA and pressure support ventilation (PSV)...
- Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot studyMarkus Zimmermann
Department of Anesthesiology, University of Regensburg Medical Center, Regensburg, Germany
Crit Care 13:R10. 2009..In the present pilot study we tested the hypothesis that timely initiation of iLA using clear algorithms and an improved cannulation technique will positively influence complication rates and management of lung protective ventilation...
- Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndromeL B Ware
Cardiovascular Research Institute, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
Am J Respir Crit Care Med 163:1376-83. 2001....
- Influence of airway management on ventilator-associated pneumonia: evidence from randomized trialsD Cook
Department of Medicine, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
JAMA 279:781-7. 1998..Many interventions have been studied to reduce the risk of VAP. We systematically reviewed the influence of airway management on VAP in critically ill patients...
- Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trialJean-Claude Lacherade
Medical Unit, Henri Mondor Hospital, , France
Am J Respir Crit Care Med 172:1276-82. 2005....
- Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndromeJames Orme
Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City, Utah 84143, USA
Am J Respir Crit Care Med 167:690-4. 2003..Acute respiratory distress syndrome survivors treated with high and low tidal volumes have abnormal pulmonary function that was related to decreased health-related quality of life 1 year after hospital discharge...
- Pre-ejection period variations predict the fluid responsiveness of septic ventilated patientsMarc Feissel
Intensive Care Unit, Centre Hospitalier, Belfort, France
Crit Care Med 33:2534-9. 2005..CONCLUSIONS: The present study found DeltaPEPKT and DeltaPEPPLET to be as accurate as DeltaPP in the prediction of fluid responsiveness in mechanically ventilated septic patients...
- A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients. Influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumoniaL Holzapfel
Service de Réanimation et Service de Bactériologie, Centre Hospitalier, Bourg en Bresse and Département de Biostastistique et Informatique Médicale, Hopital Saint Louis, Paris, France
Am J Respir Crit Care Med 159:695-701. 1999..The effect on mortality should be confirmed...
- First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unitSaad Nseir
Intensive Care Unit, Calmette Hospital, Regional University Centre, Lille, France
Crit Care Med 33:283-9. 2005..CONCLUSION: FQ use and longer duration of antibiotic treatment are independently associated with MRB emergence. Reducing antimicrobial treatment duration and restricting FQ use could be suggested to control MRB spread in the ICU...
- Lung-protective ventilation strategies in acute lung injuryRoy G Brower
Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 31:S312-6. 2003..It is not yet clear whether the open-lung approach will further reduce mortality in patients receiving volume- and pressure-limited ventilation support...
- Noninvasive cardiac output measurement using partial carbon dioxide rebreathing is less accurate at settings of reduced minute ventilation and when spontaneous breathing is presentKazuya Tachibana
Surgical Intensive Care Unit, National Cardiovascular Center, Osaka, Japan
Anesthesiology 98:830-7. 2003..The objectives of the current study were to investigate whether tidal volume or minute ventilation is the dominant factor for the accuracy, and the accuracy of the technique when spontaneous breathing effort is present...
- Liquid ventilation: an adjunct for respiratory managementMarla R Wolfson
Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Paediatr Anaesth 14:15-23. 2004..Currently, there are several theoretical and practical applications of LAV in the immature or mature lung at risk for acute respiratory distress and injury associated with mechanical ventilation...
- The impact of delirium on the survival of mechanically ventilated patientsShu-Min Lin
Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
Crit Care Med 32:2254-9. 2004..24-41.18) were independent predictors of mortality. CONCLUSIONS: This study confirms previous work showing that delirium is an independent predictor for increased mortality among mechanically ventilated patients...
- Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lungMariko Kotani
Department of Anesthesiology, School of Medicine, Keio University, Japan
Crit Care Med 32:514-9. 2004..This study suggests that large Vt ventilation potentiates the predisposed, subclinical lung injury, such as nosocomial pneumonia or aspiration of gastric contents...
- Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trialRichard R Riker
University of Vermont College of Medicine, USA
JAMA 301:489-99. 2009..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
- A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injuryDuane J Funk
Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
Respir Res 5:22. 2004....
- The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials GroupD K Heyland
Department of Medicine, Queen s University, Kingston, Ontario, Canada
Chest 115:1076-84. 1999..To evaluate the clinical utility of bronchoscopy with protected brush catheter (PBC) and BAL for patients with ventilator-associated pneumonia (VAP)...
- Impact of low pulmonary vascular pressure on ventilator-induced lung injuryAlain F Broccard
Division of Intensive Care, Department of Medicine, University Hospital, Lausanne, Switzerland
Crit Care Med 30:2183-90. 2002..05; C vs. A and B). CONCLUSION: Reducing left atrial pressure results in more severe ventilator-induced lung injury. These results suggest that lung blood volume modulates cyclic tidal lung stress...
- Indicators for tracheostomy in patients with traumatic brain injuryStan A Gurkin
Division of Trauma and Critical Care, Henry Ford Hospital, Detroit, Michigan 48202, USA
Am Surg 68:324-8; discussion 328-9. 2002..Performing TR late did not reduce pneumonia rates or ventilator, ICU, or hospital days. By identifying the at-risk population early TR could be performed in an attempt to decrease morbidity and length of stay...
- ICU-acquired weaknessWilliam D Schweickert
Pulmonary Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 6026, Chicago, IL 60657, USA
Chest 131:1541-9. 2007..We advocate an approach to this common syndrome that identifies risk factors early in the hope of minimizing their impact...
- Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled studyD C Bergmans
Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
Am J Respir Crit Care Med 164:382-8. 2001..cross infection, prevention and control; respiration, artificial, adverse effects; antibiotics, administration and dosage infection control methods; pneumonia, etiology, prevention and control; intubation, intratracheal, adverse effects..
- Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)E W Ely
Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
JAMA 286:2703-10. 2001..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
- Comparison of B-mode ultrasound and computed tomography in the diagnosis of maxillary sinusitis in mechanically ventilated patientsG Hilbert
Medical Intensive Care Unit, University Hospital of Bordeaux, Bordeaux, France
Crit Care Med 29:1337-42. 2001..CONCLUSION: B-mode ultrasound may be proposed first-line in a ventilated patient with suspicion of maxillary sinusitis...
- Impact of Gram-positive resistance on outcome of nosocomial pneumoniaM Bodi
Department of Critical Care, Hospital Universitari Joan XXIII, University Rovira i Virgili, Tarragona, Spain
Crit Care Med 29:N82-6. 2001..Optimizing treatment focusing on this goal and new antimicrobials provide new opportunities to improve survival. (Crit Care Med 2001; 29[Suppl.]:N82-N86)..
- Effect of the mechanical ventilatory cycle on thermodilution right ventricular volumes and cardiac outputA B Groeneveld
Medical Intensive Care Unit, Institute for Cardiovascular Research, Free University Hospital, 1081 HV Amsterdam, The Netherlands
J Appl Physiol 89:89-96. 2000..We conclude that cyclic RV afterloading necessitates multiple thermodilution measurements equally spaced in the ventilatory cycle for reliable assessment of RV performance during mechanical ventilation of patients...
- Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm functionPeter J Radell
Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, 17176 Stockholm, Sweden
Intensive Care Med 28:358-64. 2002..This study used an animal model simulating the critical care environment to investigate the effects of 5 days' mechanical ventilation and inactivity on diaphragm contractility and neurophysiologic function...
- The prognostic significance of passing a daily screen of weaning parametersE W Ely
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Intensive Care Med 25:581-7. 1999..We evaluated whether passing weaning parameters was associated with survival...
- Clinical review: severe asthmaSpyros Papiris
Department of Critical Care and Pulmonary Services, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece
Crit Care 6:30-44. 2002..Finally, after successful treatment and prior to discharge, a careful strategy for prevention of subsequent asthma attacks is imperative...
- Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysisMark Duffett
Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
Crit Care 11:R66. 2007..The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure...
- Effect of hemodialysis on intra-abdominal pressureRoberta Fernandes Bonfim
Hospital das Clinicas, Medical School, Sao Paulo University, Sao Paulo, SP, Brazil
Clinics (Sao Paulo) 62:145-50. 2007..To study the effect of hemodialysis on intra-abdominal pressure...
- Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammationMartin C J Kneyber
Department of Pediatric Intensive Care, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Crit Care 13:R87. 2009..We hypothesized that mechanical ventilation (MV) augmented sepsis-induced myocardial CML deposition and inflammation...
- Noninvasive positive pressure ventilation in the acute care setting: where are we?N Ambrosino
Pulmonary and Respiratory Intensive Care Unit, Cardio Thoracic Dept, University Hospital Pisa, Italy
Eur Respir J 31:874-86. 2008..Additionally, the technique must be applied in the appropriate location by a trained team in order to avoid disappointing results...
- Diagnosis of ventilator-associated pneumonia: a systematic review of the literatureAlvaro Rea-Neto
Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, 07743 Jena, Germany
Crit Care 12:R56. 2008....
- Intercomparison of recruitment maneuver efficacy in three models of acute lung injurySung-Chul Lim
Department of Pulmonary/Critical Care Medicine, Regions Hospital, University of Minnesota, St. Paul, MN, USA
Crit Care Med 32:2371-7. 2004..Although RM may improve PaO2 in certain injury settings when traditional tidal volumes are used, sustained improvement depends on the post-RM positive end-expiratory pressure value...
- An evaluation of protocolised weaning on the duration of mechanical ventilationB Blackwood
Nursing and Midwifery Research Unit, Queen s University Belfast, 21 Stranmillis Road, Belfast, N Ireland
Anaesthesia 61:1079-86. 2006..Protocolised weaning did not reduce the duration of mechanical ventilation and was not associated with an increased rate of re-intubation or intensive care unit mortality...
- Ventilator-associated pneumonia caused by high risk microorganisms: a matched case-control studyMelda Aybar Türkoğlu
Medical Intensive Care Unit, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey
Tuberk Toraks 56:139-49. 2008..To determine the impact of ventilator-associated pneumonia (VAP) caused by high risk microorganisms (HRM) on patient outcome...
- The effect of open lung ventilation on right ventricular and left ventricular function in lung-lavaged pigsDinis Reis Miranda
Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands
Crit Care 10:R86. 2006..We hypothesize that when atelectasis is minimized by OLC ventilation, cardiac function is not affected despite the higher mean airway pressure...
- Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patientsEvert de Jonge
Department of Intensive Care, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Crit Care 12:R156. 2008..The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO2) and achieved arterial partial pressure of oxygen (PaO2)...
- Management strategies for patients with pulmonary hypertension in the intensive care unitRoham T Zamanian
Stanford University Medical Center, Stanford, CA, USA
Crit Care Med 35:2037-50. 2007....
- Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressureChung Chi Huang
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
Crit Care Med 36:2810-6. 2008....
- Management and outcomes of pediatric patients transported by emergency medical services in a Canadian prehospital systemJulie Richard
Faculty of Medicine, University of Ottawa, Ottawa, ON
CJEM 8:6-12. 2006..Very few children receive prehospital airway management, ventilation or IV medications; consequently EMS personnel have little opportunity to maintain these pediatric skills in the field...
- Massive hospital admission of patients with respiratory failure resulting from smoke inhalation injury: the Cromagnon Republic TragedyG Ramos
Intensive Care Unit, Cosme Argerich Hospital, Buenos Aires, Argentina
J Burn Care Res 27:842-7. 2006
- Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndromeE Wesley Ely
Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
Ann Intern Med 136:25-36. 2002....
- Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shockAlessandro Pontes-Arruda
, Department of Intensive Care, Fortaleza, Cear, Brazil
Crit Care Med 34:2325-33. 2006....
- Increased use of noninvasive ventilation in French intensive care unitsAlexandre Demoule
, AP-HP, , 51 Av du Mal de Lattre de Tassigny, 94000, , France
Intensive Care Med 32:1747-55. 2006..The proportion of patients successfully treated with NIV increased significantly over the 5-year period (13% vs. 9% of all patients receiving ventilatory support)...
- Ventilator Y-piece pressure compared with intratracheal airway pressure in healthy intubated childrenOmer Nasiroglu
Department of Anesthesiology, University of Florida, Gainesville, USA
J Clin Monit Comput 20:95-100. 2006....
- Intratracheal pressure: a more accurate reflection of pulmonary airway pressure in pediatric patients with respiratory failureRogelio H Dela Cruz
Department of Pediatrics, University of Florida College of Medicine, Gainesville, USA
Pediatr Crit Care Med 6:175-81. 2005..Clinicians need to be aware of the limitations of P(vent) data and consider using ETTs that allow measurement of P(T), a more accurate reflection of pulmonary airway pressure...
- Equitable resource allocation in the intensive care unit: a descriptive ethical caseElchanan Lewis
Beit Midrash of Western Australia, Dianella, WA, Australia
Crit Care Resusc 8:123-8. 2006..Six of these ethical questions have been presented to leading physicians and an ethicist, from a range of national, cultural and religious backgrounds, for their comment...
- Lung recruitment: the role of recruitment maneuversDean R Hess
Department of Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Respir Care 47:308-17; discussion 317-8. 2002..There have been a number of recent reports describing improvements in arterial oxygenation with the use of recruitment maneuvers. However, the impact of recruitment maneuvers on patient-important outcomes such as survival is unknown...
- Heat and moisture exchangers and heated humidifiers in acute lung injury/acute respiratory distress syndrome patients. Effects on respiratory mechanics and gas exchangeIndalecio Morán
Servei de Medicina Intensiva, Hospital de la Santa Creu i Sant Pau, Sant Antoni M Claret 167, 08025, Barcelona, Spain
Intensive Care Med 32:524-31. 2006....
- Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndromeRichard H Kallet
Critical Care Division, Department of Anesthesia, University of California, San Francisco at San Francisco General Hospital, San Francisco, CA 94110, USA
Crit Care Med 34:8-14. 2006..To assess the effects of step-changes in tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury (ALI) or the acute respiratory distress syndrome (ARDS)...
- Noninvasive vs conventional mechanical ventilation in acute respiratory failure: a multicenter, randomized controlled trialTeresa Honrubia
, Hospital Universitario Puerta de Hierro, , 4, 28035 Madrid, Spain
Chest 128:3916-24. 2005..There is a nonsignificant trend of reduction in ICUs and hospital mortality together with fewer complications during ICU stay...
- Current issues in mechanical ventilation for respiratory failureNeil R MacIntyre
Pulmonary and Critical Care Medicine, Duke University Medical Center, Room 7453 Duke Hospital, Box 3911 Medical Center, Durham, NC 27710, USA
Chest 128:561S-567S. 2005..These efforts involve the initiation of spontaneous-breathing trials, implementation of systematic weaning protocols, and optimization of individual patient interventions...
- Noninvasive positive-pressure ventilation for postextubation respiratory distress: a randomized controlled trialSean P Keenan
Department of Medicine, Royal Columbian Hospital, New Westminster, British Columbia, Canada
JAMA 287:3238-44. 2002..It is also used for patients who develop acute respiratory distress after extubation, but there are no randomized controlled trials that address its effectiveness in this population...
- [Applications of non-invasive mechanical ventilation in patients receiving endotracheal ventilation]S Diaz Lobato
Unidad de Ventilación Mecánica No Invasiva y Domiciliaria Servicio de Neumología Hospital Universitario La Paz Madrid Spain
Arch Bronconeumol 38:281-4. 2002
- Effects of short-term pressure-controlled ventilation on gas exchange, airway pressures, and gas distribution in patients with acute lung injury/ARDS: comparison with volume-controlled ventilationMaura Prella
Multidisciplinary ICU, Regional Hospital La Carit, 6600 Locarno, Switzerland
Chest 122:1382-8. 2002....
- Non-invasive mechanical ventilation: a practice not for all seasonsL Bianchi
Monaldi Arch Chest Dis 65:126-7. 2006
- A critical appraisal of a randomized controlled trial: Willson et al: Effect of exogenous surfactant (calfactant) in pediatric acute lung injury (JAMA 2005, 293: 470-476)Angela S Czaja
Children's Hospital and Regional Medical Center, University of Washington, Department of Pediatric Critical Care, Seattle, WA, USA
Pediatr Crit Care Med 8:50-3. 2007..Given the uncertainty of the benefits, calfactant cannot be routinely recommended in pediatric ALI/ARDS...
- Early intensive care unit mobility therapy in the treatment of acute respiratory failurePeter E Morris
Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC, USA
Crit Care Med 36:2238-43. 2008..Despite the theoretical advantages of physical therapy to address this problem, it has not been shown that physical therapy initiated in the intensive care unit offers benefit...
- Assessment of neonatal ventilation during high-frequency oscillatory ventilationWendy J Sturtz
Division of Neonatology, Department of Pediatrics, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Pediatr Crit Care Med 9:101-4. 2008..To determine alterations in high-frequency oscillatory ventilation (HFOV) performance during clinical ventilator management...
- Flex: a new computerized system for mechanical ventilationFleur T Tehrani
Department of Electrical Engineering, California State University, Fullerton, CA, USA
J Clin Monit Comput 22:121-30. 2008..To describe and evaluate a new weaning and decision support system for mechanical ventilation...
- A (large) step toward improved lung protectionGerhard K Wolf
Pediatr Crit Care Med 9:127-8. 2008
- Automatic selection of breathing pattern using adaptive support ventilationJean Michel Arnal
Hôpital Font Pré, Service de Reanimation Polyvalente, 1208 Avenue du Colonel Picot, 83100 Toulon, France
Intensive Care Med 34:75-81. 2008..In a cohort of mechanically ventilated patients to compare the automatic tidal volume (VT)-respiratory rate (RR) combination generated by adaptive support ventilation (ASV) for various lung conditions...
- Noninvasive versus conventional mechanical ventilation. An epidemiologic surveyA Carlucci
, Department of Biostatistics, Medical Intensive Care Unit, , Henri Mondor Hospital, , France
Am J Respir Crit Care Med 163:874-80. 2001..Failure of NIV was associated with a longer length of stay. In conclusion, NIV can be successful in selected patients, and is associated with a lower risk of pneumonia and death than is ETI...
- Unplanned extubation in orally intubated medical patients in the intensive care unit: a prospective cohort studyCarmen Bouza
Intensive Care Unit, Hospital General Universitario, Gregorio Maranon, Madrid, Spain
Heart Lung 36:270-6. 2007..Unplanned endotracheal extubation (UE) is recognized as the most common airway adverse event in the intensive care unit (ICU)...
- Clinical relevance of monitoring respiratory mechanics in the ventilator-supported patient: an update (1995-2000)L Appendini
Pulmonary Division, Ospedali Riuniti di Bergamo, Bergamo, Italy
Curr Opin Crit Care 7:41-8. 2001..Thanks to it, new ventilatory strategies and modalities have been developed. Finally, on-line monitoring of respiratory mechanics parameters is going to be more than a future perspective...
- Tracheal pressure regulated volume assist ventilation in acute respiratory failureTomislav Mirkovic
McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Room M4 10, Montreal, Quebec H3A 1A1, Canada
Can J Anaesth 54:420-9. 2007..We therefore compared the effects of Pao and Ptr regulated VAV on breathing pattern and inspiratory effort...
- Closed system endotracheal suctioning maintains lung volume during volume-controlled mechanical ventilationM Cereda
Department of Anesthesia and Intensive Care, Ospedale S. Gerardo dei Tintori, University of Milan-Bicocca, Via Donizetti 106, Monza, MI, 20052 Italy
Intensive Care Med 27:648-54. 2001....
- Assist-control ventilation vs. low levels of pressure support ventilation on sleep quality in intubated ICU patientsBénédicte Toublanc
Department of Respiratory Medicine, Centre Hospitalier Universitaire Sud, Avenue Rene Laennec, 80054, Amiens Cedex 1, France
Intensive Care Med 33:1148-54. 2007..To compare the impact of assist-control ventilation (ACV) and pressure support ventilation with 6 cmH2O inspiratory pressure (low PSV) on sleep quality...
- Community-acquired pneumonia requiring admission to an intensive care unit: a descriptive studyThomas J Marrie
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Medicine (Baltimore) 86:103-11. 2007..Severe CAP requiring admission to the ICU is common, and the decision about which patients to admit often requires clinical judgment that in many cases appears at odds with various validated pneumonia severity scoring systems...
- Controversies in the critical care setting. Should adaptive pressure control modes be utilized for virtually all patients receiving mechanical ventilation?Richard D Branson
Division of Trauma and Critical Care, Department of Surgery, University of Cincinnati Medical Center, 231 Albert Sabin Way, Room 2457, Cincinnati, OH 45267 0558, USA
Respir Care 52:478-85; discussion 485-8. 2007..Clinicians should be aware of the limitations of adaptive pressure control and understand when other breath delivery techniques are more suitable...
- Respiratory therapies in the critical care setting. Should every mechanically ventilated patient be monitored with capnography from intubation to extubation?Ira M Cheifetz
Department of Pediatric Critical Care Medicine, Duke Children s Hospital, Durham, NC 27710, USA
Respir Care 52:423-38; discussion 438-42. 2007..We hope that as new data become available, the answer to this capnography question will become clear...
- Chronic obstructive pulmonary disease and weaning of difficult-to-wean patients from mechanical ventilation: randomized prospective studyIvo Matić
Department of Anaesthesiology and Intensive Care, Dr Josip Bencevic General Hospital, Slavonski Brod, Croatia
Croat Med J 48:51-8. 2007..To compare T-tube and pressure support ventilation (PSV) as two methods of mechanical ventilation weaning of patients with chronic obstructive pulmonary disease (COPD) after failed extubation...
- Outcomes of morbidly obese patients requiring mechanical ventilation for acute respiratory failureAlexander G Duarte
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
Crit Care Med 35:732-7. 2007..To examine the outcomes of morbidly obese patients with acute respiratory failure treated with mechanical ventilation...
- Non-invasive ventilation for cancer patients with life-support techniques limitationAnne Pascale Meert
Department of Intensive Care and Thoracic Oncology, Institut Jules Bordet, Brussels, Belgium
Support Care Cancer 14:167-71. 2006....
- Predictors of hospital outcome and intubation in COPD patients admitted to the respiratory ICU for acute hypercapnic respiratory failureIrfan Ucgun
Department of Chest Diseases, Medical Faculty, Osmangazi University, Tr 26040, Eskisehir, Turkey
Respir Med 100:66-74. 2006..Mortality rate, the possible factors affecting mortality and intubation in patients with acute exacerbation of chronic obstructive pulmonary diseases (COPD) and hypercapnic respiratory failure (RF) are yet unclear...
- Endotracheal tube intraluminal volume loss among mechanically ventilated patientsChirag Shah
Pulmonary and Critical Care Division, Washington University School of Medicine, St. Louis, MO 63110, USA
Crit Care Med 32:120-5. 2004..5 +/- 0.4 vs. 6.7 +/- 1.2 mm, p <.001). CONCLUSIONS: Endotracheal tube intraluminal volume loss is common among patients with acute respiratory failure requiring mechanical ventilation and increases with prolonged tracheal intubation...
- Prone positioning in patients with acute respiratory distress syndromeGemma Rialp
Servei Medicina Intensiva, Complex Hospitalari de Mallorca, , 07012 Palma de Mallorca, Spain
Respir Care Clin N Am 8:237-45, vi-vii. 2002..This article reviews the rationale for using prone positioning in ARDS patients who require intubation and mechanical ventilation...
Research Grants145 found, 100 shown here
- Development of a Photoactivated Respiratory Support DeviceRichard Gilbert; Fiscal Year: 2009..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
- Development of a Photoactivated Respiratory Support DeviceRichard Gilbert; Fiscal Year: 2007..on this preliminary experience in order to develop a microfluidic scale device capable of carrying out artificial respiration powered by photocatalysis...
- Measuring /Improving Quality of Life in Acute Lung InjuryChristopher Cox; Fiscal Year: 2007..These results will inform clinical trial outcomes measures as well as highlight targets for interventions designed to improve survivors' HRQL. ..
- DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTSJudith Rabkin; Fiscal Year: 2003..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
- MECHANICAL VENTILATION AND RESPIRATORY MUSCLESScott Powers; Fiscal Year: 2004..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
- CHRONIC LUNG INJURY AFTER PREMATURE BIRTHRichard Bland; Fiscal Year: 2003....
- Mechanical Ventilation and Diaphragmatic Oxidant InjuryScott Powers; Fiscal Year: 2007..abstract_text> ..
- Exercise, Antioxidants, and I-R InjuryScott Powers; Fiscal Year: 2006..abstract_text> ..
- Aerosolized PGE1 in Neonatal Pulmonary HypertensionBEENA SOOD; Fiscal Year: 2005..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
- Modafinil Treatment for Fatigue in HIV+ PatientsJudith Rabkin; Fiscal Year: 2007..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
- Reducing Sedative Exposure in Ventilated ICU PatientsLinda Chlan; Fiscal Year: 2007....
- Outcomes of Prolonged Mechanical VentilationShannon Carson; Fiscal Year: 2006..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
- Weaning from Prolonged Mechanical VentilationAmal Jubran; Fiscal Year: 2007..Such information will provide for the first time solid scientific evidence to health care providers, and help them formulate objective guidelines for the management of patients being weaned at a LTAC facility. ..
- DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMESJudith Rabkin; Fiscal Year: 2004..The data collected in the preliminary study will be used in the full-scale study. ..
- Reducing Sedative Exposure in Ventilated ICU PatientsLinda Chlan; Fiscal Year: 2009..abstract_text> ..
- Mechanical ventilation, oxidative stress, and diaphragmatic atrophyScott Powers; Fiscal Year: 2009..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDale Needham; Fiscal Year: 2009..End of Abstract) ..
- Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinRichard Bland; Fiscal Year: 2009..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
- Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinRICHARD DAVID BLAND; Fiscal Year: 2010..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDALE MURRAY contact NEEDHAM; Fiscal Year: 2010..End of Abstract) ..
- Mechanical ventilation, oxidative stress, and diaphragmatic atrophySCOTT KLINE POWERS; Fiscal Year: 2010..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDale Needham; Fiscal Year: 2009..End of Abstract) ..
- Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinRichard Bland; Fiscal Year: 2009..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
- Central Respiratory Effects of Organophosphate PoisoningRomolo Gaspari; Fiscal Year: 2007..The goal of the applicant is to become an independent researcher in the area of neurophysiology and neurotoxicology with the ability to run his own laboratory and write successful grant applications. ..
- Palliation of Thirst in Intensive Care Unit PatientsKathleen Puntillo; Fiscal Year: 2009..The study will also identify the most important factors that make ICU patients thirsty so that future research studies can test how to relieve those factors and/or make interventions for thirst more readily available. ..
- Palliation of Thirst in Intensive Care Unit PatientsKathleen A Puntillo; Fiscal Year: 2010..The study will also identify the most important factors that make ICU patients thirsty so that future research studies can test how to relieve those factors and/or make interventions for thirst more readily available. ..
- Stretch and Vitamin A Effects on Alveolar FormationKURT ALBERTINE; Fiscal Year: 2009..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
- Assessing and Treating Symptoms of Dying ICU PatientsKathleen Puntillo; Fiscal Year: 2006..Results will also contribute empirical data needed to generate and test hypotheses concerning appropriate symptom assessment and management interventions. ..
- Strategies for Airway Management & Prevention Endotracheal Tube Cuff InterventionMARY SOLE; Fiscal Year: 2007..Findings will assist in designing airway management interventions and technologies to improve the outcomes of critically ill patients, and inform the development of an intervention/technology package to reduce VAP. ..
- Oxygen, Oxidant Stress and Wheezing in Premature InfantsTimothy Stevens; Fiscal Year: 2007..By evaluating the effect of oxygen exposure on oxidant stress and airway dysfunction this award will identify new therapeutic approaches to improve respiratory health of preterm infants in early childhood. ..
- LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 1999..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..
- Quality of Care and Outcomes of Healthcare-Associated PneumoniaMichael B Rothberg; Fiscal Year: 2010..If recommended therapy is beneficial but underutilized, these results will alert quality improvement officers and policy makers to an important opportunity to improve patient care for a common and deadly illness. ..
- VITAMIN A EFFECTS ON ALVEOLAR FORMATIONKURT ALBERTINE; Fiscal Year: 2002..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
- CHRONIC LUNG INJURY AFTER PREMATURE BIRTHKURT ALBERTINE; Fiscal Year: 2001....
- Home Automatic external Defibrillator TrainingThomas Rea; Fiscal Year: 2007..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. ..
- LIVER-LUNG INTERACTIONS DURING GRAM-NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 1993..This will enable a synthesis integrating the signal transduction of peptide and non-peptide mediators with organ system interactions, and provide further insight into potential therapeutic interventions to ameliorate ARDS with MSOF...
- LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIAGeorge Matuschak; Fiscal Year: 2003....
- Human genetic variation and ventricular fibrillation resuscitation outcomesThomas D Rea; Fiscal Year: 2010..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..