genetic hybridization

Summary

Summary: The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.

Top Publications

  1. ncbi Hybrid speciation
    James Mallet
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    Nature 446:279-83. 2007
  2. pmc A model-based method for identifying species hybrids using multilocus genetic data
    E C Anderson
    Department of Statistics, University of Washington, Seattle, Washington 98195, USA
    Genetics 160:1217-29. 2002
  3. ncbi Transgressive segregation, adaptation and speciation
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Heredity (Edinb) 83:363-72. 1999
  4. ncbi The role of hybridization in evolution
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 10:551-68. 2001
  5. doi Genomic plasticity and the diversity of polyploid plants
    A R Leitch
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
    Science 320:481-3. 2008
  6. ncbi Speciation via introgressive hybridization in East African cichlids?
    W Salzburger
    Department of Zoology and Limnology, University of Innsbruck, Technikerstrasse 25, A 6020 Innsbruck, Austria
    Mol Ecol 11:619-25. 2002
  7. pmc A genomic view of introgression and hybrid speciation
    Eric J Baack
    Department of Botany, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Genet Dev 17:513-8. 2007
  8. doi The hidden side of invasions: massive introgression by local genes
    Mathias Currat
    Computational and Molecular Population Genetics Laboratory, Institute of Zoology, University of Bern, Baltzerstrasse 6, 3012 Berne, Switzerland
    Evolution 62:1908-20. 2008
  9. ncbi Major ecological transitions in wild sunflowers facilitated by hybridization
    Loren H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 301:1211-6. 2003
  10. doi Dynamics of polyploid formation in Tragopogon (Asteraceae): recurrent formation, gene flow, and population structure
    V Vaughan Symonds
    Florida Museum of Natural History, University of Florida, Gainesville, Florida 32611, USA
    Evolution 64:1984-2003. 2010

Detail Information

Publications247 found, 100 shown here

  1. ncbi Hybrid speciation
    James Mallet
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    Nature 446:279-83. 2007
    ..Now, new genetic evidence suggests that hybrid speciation, even without polyploidy, is more common in plants and also animals than we thought...
  2. pmc A model-based method for identifying species hybrids using multilocus genetic data
    E C Anderson
    Department of Statistics, University of Washington, Seattle, Washington 98195, USA
    Genetics 160:1217-29. 2002
    ..We demonstrate the method on allozyme data from two species of hybridizing trout, as well as on two simulated data sets...
  3. ncbi Transgressive segregation, adaptation and speciation
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Heredity (Edinb) 83:363-72. 1999
    ..These results lend credence to the view that hybridization may provide the raw material for rapid adaptation and provide a simple explanation for niche divergence and phenotypic novelty often associated with hybrid lineages...
  4. ncbi The role of hybridization in evolution
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 10:551-68. 2001
    ..Moreover, because adaptation is via substitutions of small effect, Fisher's model does not generate the strong effects of single chromosome regions often observed in species crosses...
  5. doi Genomic plasticity and the diversity of polyploid plants
    A R Leitch
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
    Science 320:481-3. 2008
    ..This process has been a major driving force behind the divergence of the angiosperms and their biodiversity...
  6. ncbi Speciation via introgressive hybridization in East African cichlids?
    W Salzburger
    Department of Zoology and Limnology, University of Innsbruck, Technikerstrasse 25, A 6020 Innsbruck, Austria
    Mol Ecol 11:619-25. 2002
    ..Hence, our finding displays another mode of speciation in cichlid fishes. The increase of genetic and phenotypic diversity due to hybridization may contribute to the uniquely rapid pace of speciation in cichlids...
  7. pmc A genomic view of introgression and hybrid speciation
    Eric J Baack
    Department of Botany, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Genet Dev 17:513-8. 2007
    ....
  8. doi The hidden side of invasions: massive introgression by local genes
    Mathias Currat
    Computational and Molecular Population Genetics Laboratory, Institute of Zoology, University of Bern, Baltzerstrasse 6, 3012 Berne, Switzerland
    Evolution 62:1908-20. 2008
    ..Our results imply that speciation genes can be identified by comparing genomes of interfertile native and invading species pairs...
  9. ncbi Major ecological transitions in wild sunflowers facilitated by hybridization
    Loren H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 301:1211-6. 2003
    ..The same combinations of parental chromosomal segments required to generate extreme phenotypes in synthetic hybrids also occurred in ancient hybrids. Thus, hybridization facilitated ecological divergence in sunflowers...
  10. doi Dynamics of polyploid formation in Tragopogon (Asteraceae): recurrent formation, gene flow, and population structure
    V Vaughan Symonds
    Florida Museum of Natural History, University of Florida, Gainesville, Florida 32611, USA
    Evolution 64:1984-2003. 2010
    ..Our data also indicate a lack of gene flow among polyploid plants of independent origin, even when they co-occur, suggesting potential reproductive barriers among separate lineages in both polyploid species...
  11. ncbi Contrasting patterns of mitochondrial DNA and microsatellite introgressive hybridization between lineages of lake whitefish (Coregonus clupeaformis); relevance for speciation
    G Lu
    GIROQ, , , Ste-Foy, , Canada G1K 7P4
    Mol Ecol 10:965-85. 2001
    ..Thus, each lake may be viewed as a different temporal snapshot taken throughout the gradual process of speciation...
  12. ncbi Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 423:715-9. 2003
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
  13. doi A yeast hybrid provides insight into the evolution of gene expression regulation
    Itay Tirosh
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Science 324:659-62. 2009
    ..These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization...
  14. ncbi Natural selection for salt tolerance quantitative trait loci (QTLs) in wild sunflower hybrids: implications for the origin of Helianthus paradoxus, a diploid hybrid species
    C Lexer
    Department of Biology, Jordan Hall 142, 1001 East Third Street, Indiana University, Bloomington, IN 47405, USA
    Mol Ecol 12:1225-35. 2003
    ..paradoxus. Finally, selection coefficients of +0.126, -0.084 and -0.094 for the three survivorship QTLs, respectively, are sufficiently large to account for establishment of new, homoploid hybrid species...
  15. ncbi A rapidly evolving homeobox at the site of a hybrid sterility gene
    C T Ting
    Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
    Science 282:1501-4. 1998
    ..Such rapid sequence divergence is driven by positive selection and may contribute to reproductive isolation...
  16. pmc Genomewide nonadditive gene regulation in Arabidopsis allotetraploids
    Jianlin Wang
    Department of Agronomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 172:507-17. 2006
    ....
  17. ncbi The likelihood of homoploid hybrid speciation
    C A Buerkle
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Heredity (Edinb) 84:441-51. 2000
    ..Our results confirmed the importance of the combination of factors that had been emphasized in verbal models and illustrate the trade-off between the frequency at which hybrid species arise and the genetic integrity of incipient species...
  18. doi Complete mitochondrial DNA replacement in a Lake Tanganyika cichlid fish
    B Nevado
    Department Vertebrates, Royal Belgian Institute of Natural Sciences, 1000 Brussels, Belgium
    Mol Ecol 18:4240-55. 2009
    ..callipterus mtDNA lineages, probably still during the water level low stand, and that subsequently the invading mtDNA lineage spread throughout the lake...
  19. ncbi Stress and domestication traits increase the relative fitness of crop-wild hybrids in sunflower
    Kristin L Mercer
    Applied Plant Sciences Program, University of Minnesota, 411 Borlaug Hall, 1991 Upper Buford Circle, St Paul, MN 55108, USA
    Ecol Lett 10:383-93. 2007
    ..Rigorous assessment of how particular genotypes, phenotypes, and environments affect introgression will improve risk assessment for transgenic crops...
  20. pmc Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus
    Daniel A Barbash
    Section of Evolution and Ecology, University of California, Davis, USA
    PLoS Biol 2:e142. 2004
    ..Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles...
  21. doi Variable patterns of introgression in two sculpin hybrid zones suggest that genomic isolation differs among populations
    A W Nolte
    Max Planck Institute for Evolutionary Biology, August Thienemann Strasse 2, 24306 Plön, Germany
    Mol Ecol 18:2615-27. 2009
    ..In the future, data from mapped genetic markers and on variation of ecological factors will provide additional insights into the contribution of these factors to variation in the evolutionary consequences of hybridization...
  22. pmc Genetic dissection of an elite rice hybrid revealed that heterozygotes are not always advantageous for performance
    J P Hua
    National Key Laboratory of Crop Genetic Improvement, National Center of Crop Molecular Breeding, Huazhong Agricultural University, Wuhan 430070, China
    Genetics 162:1885-95. 2002
    ..It was concluded that heterozygotes were not necessarily advantageous for trait performance even among genotypes derived from such a highly heterotic hybrid...
  23. pmc The ecological genetics of homoploid hybrid speciation
    B L Gross
    Department of Biology, 1001 E 3rd Street, Jordan Hall 142, Indiana University, Bloomington, IN 47405, USA
    J Hered 96:241-52. 2005
    ..Overall, theory and empirical evidence gathered to date suggest that ecological selection is a major factor promoting homoploid hybrid speciation, with the strongest evidence coming from genetic studies...
  24. doi Ancient hybridization and mitochondrial capture between two species of chipmunks
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, AZ 85721, USA
    Mol Ecol 17:1313-27. 2008
    ..Our findings challenge long-standing assumptions on patterns of reproductive isolation in chipmunks and suggest that there may be other examples of hybridization among the 23 species of Tamias that occur in western North America...
  25. pmc Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression
    Rita M Graze
    Genetics Institute, Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 3261 3610, USA
    Genetics 183:547-61, 1SI-21SI. 2009
    ..In addition, two genes, with critical roles in sex determination and micro RNA processing, Sxl and loqs, were identified as misexpressed in hybrid female heads, potentially contributing to hybrid incompatibility...
  26. ncbi Interspecific hybridization in plant-associated fungi and oomycetes: a review
    C L Schardl
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546 0091, USA
    Mol Ecol 12:2861-73. 2003
    ..Hybrid mutualists may also be better adapted to new hosts and can provide greater or more diverse benefits to host plants...
  27. ncbi Hybridization and adaptive mate choice in flycatchers
    T Veen
    Department of Animal Ecology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden
    Nature 411:45-50. 2001
    ..Apparent hybridization may thus represent adaptive mate choice under some circumstances...
  28. ncbi Rates of evolution of hybrid inviability in birds and mammals
    Benjamin M Fitzpatrick
    Center for Population Biology and Section of Evolution and Ecology, University of California, Davis, California 95616, USA
    Evolution 58:1865-70. 2004
    ..I briefly discuss this and other potential explanations...
  29. ncbi Quantitative trait analysis of seed yield and other complex traits in hybrid spring rapeseed (Brassica napus L.): 2. Identification of alleles from unadapted germplasm
    Joshua A Udall
    Plant Breeding and Plant Genetics Program, and Department of Agronomy, University of Wisconsin, Madison, WI 53706, USA
    Theor Appl Genet 113:597-609. 2006
    ..In this QTL region, a chromosome rearrangement was identified in P1804, which may have affected seed yield...
  30. ncbi Complex hybridization dynamics between golden-winged and blue-winged warblers (Vermivora chrysoptera and Vermivora pinus) revealed by AFLP, microsatellite, intron and mtDNA markers
    R Vallender
    Fuller Evolutionary Biology Program, Laboratory of Ornithology, Cornell University, 159 Sapsucker Woods Road, Ithaca, NY 14850, USA
    Mol Ecol 16:2017-29. 2007
    ....
  31. doi Epigenetic, transposon and small RNA determinants of hybrid dysfunctions
    P Michalak
    Department of Biology, The University of Texas Arlington, Arlington, TX 76019 0498, USA
    Heredity (Edinb) 102:45-50. 2009
    ..The review offers a handful of glimpses into these complex dynamics...
  32. ncbi Leaky prezygotic isolation and porous genomes: rapid introgression of maternally inherited DNA
    Kai M A Chan
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544 1003, USA
    Evolution 59:720-9. 2005
    ..These findings suggest that we should use extreme caution when interpreting single gene genealogies as species phylogenies, especially for cpDNA and mtDNA...
  33. ncbi Genetic rescue of inviable hybrids between Drosophila melanogaster and its sibling species
    P Hutter
    Nature 327:331-3. 1987
    ..melanogaster females and males of its three closest relatives. The study of this locus may shed light on the genetic control of both speciation and development...
  34. doi Rapid radiation, ancient incomplete lineage sorting and ancient hybridization in the endemic Lake Tanganyika cichlid tribe Tropheini
    Stephan Koblmüller
    Department of Zoology, Karl Franzens University Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Mol Phylogenet Evol 55:318-34. 2010
    ..A large degree of correspondence between AFLP clustering and trophic types indicated fewer cases of parallel evolution of trophic ecomorphology than previously inferred from mitochondrial data...
  35. pmc The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids
    D A Barbash
    Department of Genetics, University of Cambridge, United Kingdom
    Genetics 154:1747-71. 2000
    ..melanogaster mothers. Implications of our findings for understanding Haldane's rule-the observation that hybrid breakdown is often specific to the heterogametic sex-are also discussed...
  36. pmc Hybrid zones and the genetic architecture of a barrier to gene flow between two sunflower species
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 152:713-27. 1999
    ..These results demonstrate the utility of hybrid zones for identifying factors contributing to isolation and verify the prediction of increased resolution relative to controlled crosses...
  37. ncbi Identification of differentially expressed genes in leaf and root between wheat hybrid and its parental inbreds using PCR-based cDNA subtraction
    Yingyin Yao
    Department of Plant Genetics and Breeding, Key Laboratory of Crop Genomics and Genetic Improvement, Ministry of Agriculture Beijing, China Agricultural University, 100094 Beijing, China
    Plant Mol Biol 58:367-84. 2005
    ..2%). And it was concluded that the genes differentially expressed between hybrids and their parents involved in diverse physiological process pathway, which might be responsible for the observed heterosis...
  38. pmc Intra-individual polymorphism in diploid and apomictic polyploid hawkweeds (Hieracium, Lactuceae, Asteraceae): disentangling phylogenetic signal, reticulation, and noise
    Judith Fehrer
    Institute of Botany, Academy of Sciences of the Czech Republic, Pruhonice, Czech Republic
    BMC Evol Biol 9:239. 2009
    ..Concentrating on the supposed major evolutionary units, we used nuclear ribosomal (ETS) and chloroplast (trnT-trnL) sequences in order to disentangle the phylogenetic relationships and to infer the origins of the polyploids...
  39. ncbi Weed evolution after crop gene introgression: greater survival and fecundity of hybrids in a new environment
    Lesley G Campbell
    Ecol Lett 9:1198-209. 2006
    ..270% greater lifetime fecundity and c. 22% greater survival than wild plants in CA. Our results support the hypothesis that crop-wild hybridization may create genotypes with the potential to displace parental taxa in new environments...
  40. ncbi Wolbachia-induced incompatibility precedes other hybrid incompatibilities in Nasonia
    S R Bordenstein
    Department of Biology, The University of Rochester, New York 14627, USA
    Nature 409:707-10. 2001
    ....
  41. ncbi Barrier to gene flow between two ecologically divergent Populus species, P. alba (white poplar) and P. tremula (European aspen): the role of ecology and life history in gene introgression
    C Lexer
    Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3DS, UK
    Mol Ecol 14:1045-57. 2005
    ..alba N(e)c. 500-550; P. tremula N(e)c. 550-700). Our results indicate that hybrid zones will be valuable tools for studying the genetic architecture of the barrier to gene flow between these two ecologically divergent Populus species...
  42. ncbi A role for the mismatch repair system during incipient speciation in Saccharomyces
    D Greig
    The Galton Laboratory, Department of Biology, University College London, London, UK
    J Evol Biol 16:429-37. 2003
    ..We show that these crosses are partially sterile and present evidence that the mismatch repair system is largely responsible for this sterility...
  43. pmc Hybrid lethal systems in the Drosophila melanogaster species complex. II. The Zygotic hybrid rescue (Zhr) gene of D. melanogaster
    K Sawamura
    Department of Genetics, Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka, Japan
    Genetics 133:307-13. 1993
    ..A model is proposed to explain the genetic mechanisms of hybrid lethalities as well as the evolutionary pathways...
  44. pmc Genetics of postzygotic isolation in Eucalyptus: whole-genome analysis of barriers to introgression in a wide interspecific cross of Eucalyptus grandis and E. globulus
    Alexander A Myburg
    Department of Forestry, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 166:1405-18. 2004
    ....
  45. ncbi The maintenance of reproductive isolation in a mosaic hybrid zone between the fire-bellied toads Bombina bombina and B. variegata
    T H Vines
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
    Evolution 57:1876-88. 2003
    ..The hybrid zone may be approaching a state in which the gene pools are homogenized at all but the selected loci, not dissimilar from an early stage of sympatric divergence...
  46. ncbi Hybridization in the recent past
    Peter R Grant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544 1003, USA
    Am Nat 166:56-67. 2005
    ....
  47. doi The accumulation of reproductive incompatibilities in African cichlid fish
    Rike B Stelkens
    Department of Ecology and Evolution, University of Lausanne, Biophore, CH 1015 Lausanne, Switzerland
    Evolution 64:617-33. 2010
    ..By quantifying the capacity to produce viable hybrids between allopatric, distantly related lineages our results also provide an upper divergence time limit for the "hybrid swarm origin" model of adaptive radiation...
  48. ncbi Genetics and the fitness of hybrids
    J M Burke
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Genet 35:31-52. 2001
    ..In contrast, increased hybrid fitness can be most readily explained through the segregation of additive genetic factors, with epistasis playing a more limited role...
  49. pmc Asymmetrical reinforcement and Wolbachia infection in Drosophila
    John Jaenike
    Department of Biology, University of Rochester, Rochester, New York, USA
    PLoS Biol 4:e325. 2006
    ..Given the widespread occurrence of Wolbachia among insects, it thus appears that there are multiple ways by which these endosymbionts may directly and indirectly contribute to reproductive isolation and speciation...
  50. ncbi The rise and fall of the mountain hare (Lepus timidus) during Pleistocene glaciations: expansion and retreat with hybridization in the Iberian Peninsula
    J Melo-Ferreira
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
    Mol Ecol 16:605-18. 2007
    ..Whether a similar scenario explains the introgression into Iberian L. europaeus remains unclear but it is possible that it hybridized with already introgressed L. granatensis...
  51. ncbi Speciation reversal and biodiversity dynamics with hybridization in changing environments
    Ole Seehausen
    Center of Ecology, Evolution and Biogeochemistry, Swiss Institute for Environmental Sciences and Technology EAWAG, Seestrasse 79, 6047 Kastanienbaum, Switzerland
    Mol Ecol 17:30-44. 2008
    ..Since heterogeneity of natural environments is rapidly deteriorating in most biomes, the evolutionary ecology of speciation reversal ought to be fully integrated into conservation biology...
  52. ncbi An anomalous hybrid zone in Drosophila
    Ana Llopart
    Department of Biological Sciences, University of Iowa, 215 Biology Building BB, Iowa City, Iowa 52242, USA
    Evolution 59:2602-7. 2005
    ..Third, there is a puzzling absence of hybrid females. We suggest several tentative explanations for the anomalies associated with this hybrid zone, but for the present they remain a mystery...
  53. pmc Hybridization rapidly reduces fitness of a native trout in the wild
    Clint C Muhlfeld
    US Geological Survey, Northern Rocky Mountain Science Center, Glacier National Park, West Glacier, MT 59936, USA
    Biol Lett 5:328-31. 2009
    ..This outbreeding depression suggests that even low levels of admixture may have negative effects on fitness in the wild and that policies protecting hybridized populations may need reconsideration...
  54. pmc Sequence elimination and cytosine methylation are rapid and reproducible responses of the genome to wide hybridization and allopolyploidy in wheat
    H Shaked
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    Plant Cell 13:1749-59. 2001
    ....
  55. ncbi Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila
    Nicholas J Brideau
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 314:1292-5. 2006
    ..Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene...
  56. ncbi Conspecific sperm precedence in sister species of Drosophila with overlapping ranges
    Audrey S Chang
    Department of Ecology and Evolution, The University of Chicago, 1101 E 57 Street, Chicago, Illinois 60637, USA
    Evolution 58:781-9. 2004
    ..These results suggest that noncompetitive and competitive gametic isolating barriers may contribute to reproductive isolation between D. yakuba and D. santomea...
  57. ncbi Song similarity predicts hybridization in flycatchers
    A Qvarnström
    Animal Ecology, Department of Ecology and Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    J Evol Biol 19:1202-9. 2006
    ..45% of 484 pairs; predicted 19.5%). Our results support the suggestion that song functions as the most important prezygotic isolation mechanism in many birds...
  58. ncbi Allelic variation and heterosis in maize: how do two halves make more than a whole?
    Nathan M Springer
    Cargill Center for Microbial and Plant Genomics, Department of Plant Biology, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Genome Res 17:264-75. 2007
    ..Variation for the presence of genes, the presence of novel beneficial alleles, and modified levels of gene expression in hybrids may all contribute to the heterotic phenotypes...
  59. ncbi Speciation in reverse: morphological and genetic evidence of the collapse of a three-spined stickleback (Gasterosteus aculeatus) species pair
    E B Taylor
    Department of Zoology and Biodiversity Research Centre, University of British Columbia, 6270 University Blvd, Vancouver, BC V6T 1Z4, Canada
    Mol Ecol 15:343-55. 2006
    ..Although the precise mechanism(s) responsible for elevated hybridization in the lake is unknown, the demise of the Enos Lake species pair follows the appearance of an exotic crayfish, Pascifasticus lenisculus, in the early 1990s...
  60. pmc Extended Newick: it is time for a standard representation of phylogenetic networks
    Gabriel Cardona
    Department of Mathematics and Computer Science, University of the Balearic Islands, Palma de Mallorca, Spain
    BMC Bioinformatics 9:532. 2008
    ....
  61. doi Natural selection influences AFLP intraspecific genetic variability and introgression patterns in Atlantic eels
    P A Gagnaire
    Institut des Sciences de l Evolution ISEM UMR 5554 CNRS UMII, Universite de Montpellier II, Place E Bataillon, Montpellier Cedex 5, France
    Mol Ecol 18:1678-91. 2009
    ....
  62. ncbi Genes and speciation
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Genet 5:114-22. 2004
  63. ncbi Efficiency of model-based Bayesian methods for detecting hybrid individuals under different hybridization scenarios and with different numbers of loci
    Juha Pekka Vähä
    Department of Biological and Environmental Sciences, PO Box 65, FIN 00014, University of Helsinki, Finland
    Mol Ecol 15:63-72. 2006
    ..However, separating backcrosses from purebred parental individuals requires a considerable genotyping effort (at least 48 loci), even when divergence between parental populations is high...
  64. pmc Introduction. Extent, processes and evolutionary impact of interspecific hybridization in animals
    Klaus Schwenk
    Department of Ecology and Evolution, J W Goethe University Frankfurt am Main, 60054 Frankfurt am Main, Germany
    Philos Trans R Soc Lond B Biol Sci 363:2805-11. 2008
    ..Here we provide firstly a historic perspective of hybridization research, secondly a novel attempt to assess the extent of hybridization among animals and thirdly an overview of the reviews and case studies presented in this theme issue...
  65. pmc Plant speciation
    Loren H Rieseberg
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 317:910-4. 2007
    ..Finally, species richness in plants is correlated with many biological and geohistorical factors, most of which increase ecological opportunities...
  66. pmc Evolution and expression of homeologous loci in Tragopogon miscellus (Asteraceae), a recent and reciprocally formed allopolyploid
    Jennifer A Tate
    Department of Botany, University of Florida, Gainesville, Florida 32611, USA
    Genetics 173:1599-611. 2006
    ..Synthetic F(1) hybrids between putative diploid progenitors are additive of their parental genomes, suggesting that polyploidization rather than hybridization induces genomic changes in Tragopogon...
  67. pmc Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house mice
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Evolution 62:50-65. 2008
    ..These data build on previous studies of speciation in house mice and show that the genetic basis of hybrid male sterility is fairly complex, even at this early stage of divergence...
  68. ncbi Gene transposition as a cause of hybrid sterility in Drosophila
    John P Masly
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 313:1448-50. 2006
    ..simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution...
  69. pmc Classical genetic and quantitative trait loci analyses of heterosis in a maize hybrid between two elite inbred lines
    Elisabetta Frascaroli
    Department of Agroenvironmental Sciences and Technologies, University of Bologna, 40127 Bologna, Italy
    Genetics 176:625-44. 2007
    ..Some chromosome regions presented overlaps of overdominant QTL for SW, PH, NK, and GY, suggesting pleiotropic effects on overall plant vigor...
  70. ncbi Evidence for bimodal hybrid zones between two species of char (Pisces: Salvelinus) in northwestern North America
    Z Redenbach
    Department of Zoology, Native Fish Research Group, University of British Columbia, Vancouver, BC, Canada
    J Evol Biol 16:1135-48. 2003
    ..These traits may limit interspecific pairings because of size assortative pairing and size-dependent reproductive habitat use...
  71. pmc Adaptation by introgression
    Michael L Arnold
    Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
    J Biol 8:82. 2009
    ..A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals the mosaic nature of introgression, which is probably caused by a combination of selection and demography...
  72. ncbi Adaptive gamete-recognition divergence in a hybridizing Mytilus population
    Stevan A Springer
    Department of Biosciences, Behavioural Ecology Research Group, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada
    Evolution 61:772-83. 2007
    ..edulis in the East Atlantic, drove the divergence of Lysin-M7 in M. galloprovincialis...
  73. ncbi Emerging vectors in the Culex pipiens complex
    Dina M Fonseca
    Genetics Program, Smithsonian Institution, National Museum of Natural History, 3001 Connecticut Avenue N W, Washington, DC 20008 0551, USA
    Science 303:1535-8. 2004
    ..Such hybrids between human-biters and bird-biters may be the bridge vectors contributing to the unprecedented severity and range of the West Nile virus epidemic in North America...
  74. ncbi Parent-dependent loss of gene silencing during interspecies hybridization
    Caroline Josefsson
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 16:1322-8. 2006
    ..We propose that the dosage-dependent regulation of chromatin could be a universal phenomenon affecting lethality in interspecies hybrids...
  75. ncbi Genome expansion in three hybrid sunflower species is associated with retrotransposon proliferation
    Mark C Ungerer
    Curr Biol 16:R872-3. 2006
  76. ncbi Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid
    R J O'Neill
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
    Nature 393:68-72. 1998
    ....
  77. ncbi Genetic mapping of a new set of microsatellite markers in a reference common bean (Phaseolus vulgaris) population BAT93 x Jalo EEP558
    M C M Grisi
    Escola de Agronomia, Universidade Federal de Goias, Goiania, GO, Brasil
    Genet Mol Res 6:691-706. 2007
    ....
  78. ncbi Interspecific hybridization increases transposition rates of Osvaldo
    M Labrador
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Spain
    Mol Biol Evol 16:931-7. 1999
    ..We show that inbreeding has no effect on transposition in the strains used, concluding that hybridization significantly increases the Osvaldo transposition rate...
  79. ncbi Phylogeny and phylogeography of the Liolaemus darwinii complex (Squamata: Liolaemidae): evidence for introgression and incomplete lineage sorting
    Mariana Morando
    Department of Integrative Biology, and M L Bean Life Science Museum, Brigham Young University, 401 WIDB, Provo, Utah 84602, USA
    Evolution 58:842-61. 2004
    ..Additional studies are needed in this group of lizards and in other codistributed groups to determine if Pleistocene climatic changes could be a general factor influencing the evolutionary history of a regional biota...
  80. ncbi Convergent evolution of Darwin's finches caused by introgressive hybridization and selection
    Peter R Grant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544 1003, USA
    Evolution 58:1588-99. 2004
    ..The study illustrates how species without postmating barriers to gene exchange can alternate between convergence and divergence when environmental conditions oscillate...
  81. ncbi Prevalence of interspecific hybrids amongst asexual fungal endophytes of grasses
    C D Moon
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Mol Ecol 13:1455-67. 2004
    ..Therefore, the abundance of hybrid species among grass endophytes, and their prevalence in many host populations suggests a selective advantage of hybridization for the mutualistic endophytes...
  82. ncbi Genetic basis of adaptive shape differences in the cichlid head
    R C Albertson
    Hubbard Center for Genome Studies and the Department of Zoology, University of New Hampshire, 35 Colovos Road, Durham, NH 03824, USA
    J Hered 94:291-301. 2003
    ..Moreover, we find that cosegregation of shape differences in different elements corresponds to developmental, rather than functional, units...
  83. ncbi Facultative mate choice drives adaptive hybridization
    Karin S Pfennig
    Department of Biology, Campus Box 3280, Coker Hall, University of North Carolina, Chapel Hill, NC 27599, USA
    Science 318:965-7. 2007
    ..Thus, when the benefits of mate choice vary, females may radically alter their mate selection in response to their own phenotype and their environment, even to the point of choosing males of other species...
  84. doi Haldane's rule in an avian system: using cline theory and divergence population genetics to test for differential introgression of mitochondrial, autosomal, and sex-linked loci across the Passerina bunting hybrid zone
    Matthew D Carling
    Museum of Natural Science, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Evolution 62:2600-15. 2008
    ....
  85. pmc Extensive de Novo genomic variation in rice induced by introgression from wild rice (Zizania latifolia Griseb.)
    Yong Ming Wang
    Laboratory of Molecular Epigenetics and The State Key Laboratory of Grassland and Ecology, Northeast Normal University, Changchun 130024, China
    Genetics 170:1945-56. 2005
    ..Taken together, our results imply that even cryptic alien introgression can be highly mutagenic to a recipient plant genome...
  86. ncbi The origin of ecological divergence in Helianthus paradoxus (Asteraceae): selection on transgressive characters in a novel hybrid habitat
    Christian Lexer
    Indiana University, Department of Biology, Jordan Hall 325, Bloomington, Indiana 47405, USA
    Evolution 57:1989-2000. 2003
    ..annuus and H. petiolaris. These results are consistent with the hypothesis that transgressive segregation of elemental uptake and leaf succulence contributed to the origin of salt adaptation in the diploid hybrid species H. paradoxus...
  87. pmc The basis of natural and artificial postzygotic hybridization barriers in Arabidopsis species
    Catherine Bushell
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Plant Cell 15:1430-42. 2003
    ..Our results also demonstrate that manipulation of DNA methylation can be sufficient to erect hybridization barriers, offering a potential mechanism for speciation and a means of controlling gene flow between species...
  88. ncbi Molecular cytogenetic analysis of wheat-barley hybrids using genomic in situ hybridization and barley microsatellite markers
    L Malysheva
    Institute of Plant Genetics and Crop Plant Research, IPK, Correns Str 3, 06466 Gatersleben, Germany
    Genome 46:314-22. 2003
    ..These methods were complementary and provided comprehensive information about the genomic constitution of the plants produced...
  89. ncbi QTL mapping for growth and carcass traits in an Iberian by Landrace pig intercross: additive, dominant and epistatic effects
    L Varona
    Area de Produccio Animal, Centre UdL IRTA, c Rovira Roure 177, 25198 Lleida, Spain
    Genet Res 80:145-54. 2002
    ..The results of the bidimensional genomic scan showed that the genetic architecture was mainly additive or the experimental set-up did not have enough power to detect epistatic interactions...
  90. ncbi Combined use of maternal, paternal and bi-parental genetic markers for the identification of wolf-dog hybrids
    C Vila
    Department of Evolutionary Biology, Uppsala University, Sweden
    Heredity (Edinb) 90:17-24. 2003
    ..This finding confirms that inter-specific hybridization between wolves and dogs can occur in natural wolf populations. A possible correlation between hybridization and wolf population density and disturbance deserves further research...
  91. ncbi Internal transcribed spacer repeat-specific primers and the analysis of hybridization in the Glycine tomentella (Leguminosae) polyploid complex
    Jason T Rauscher
    L H Bailey Hortorium, 228 Plant Science, Cornell University, Ithaca, NY 14853, USA
    Mol Ecol 11:2691-702. 2002
    ..Other strategies, such as the use of exclusion primers, may detect rare parental repeat types in hybrids when previous hypotheses regarding the second parental species are lacking...
  92. ncbi Assessing hybridization in natural populations of Penstemon (Scrophulariaceae) using hypervariable intersimple sequence repeat (ISSR) bands
    A D Wolfe
    Department of Plant Biology, Ohio State University, Columbus 43210 1293, USA
    Mol Ecol 7:1107-25. 1998
    ..clevelandii is a diploid hybrid species derived from P. centranthifolius and P. spectabilis; and (iii) demonstrate that pollen-mediated gene flow via hummingbird vectors is prevalent in the hybrid complex...
  93. ncbi Natural hybridization in primates: one evolutionary mechanism
    Michael L Arnold
    Department of Genetics, Life Sciences Building, University of Georgia, Athens, GA 30602, USA
    Zoology (Jena) 109:261-76. 2006
    ..e. chimpanzees and gorillas) and most likely also our extinct, close relatives in the hominid lineage...
  94. ncbi Incongruent plastid and nuclear DNA phylogenies reveal ancient intergeneric hybridization in Pilosella hawkweeds (Hieracium, Cichorieae, Asteraceae)
    Judith Fehrer
    Institute of Botany, Academy of Sciences of the Czech Republic, 25243 Průhonice, Czech Republic
    Mol Phylogenet Evol 42:347-61. 2007
    ..These chloroplast capture events, the first of which involved a now extinct haplotype, are the most likely explanation for the observed incongruencies between plastid and nuclear DNA markers...
  95. doi Metrics for phylogenetic networks I: generalizations of the Robinson-Foulds metric
    Gabriel Cardona
    University of the Balearic Islands, Palma de Mallorca, Spain
    IEEE/ACM Trans Comput Biol Bioinform 6:46-61. 2009
    ..We analyze the behavior of these metrics by studying their least and largest values and when they achieve them. As a by-product of this study, we obtain tight bounds on the size of a tree-child time consistent phylogenetic network...
  96. ncbi Phylogeographic inferences concerning evolution of Brazilian Passiflora actinia and P. elegans (Passifloraceae) based on ITS (nrDNA) variation
    Aline P Lorenz-Lemke
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, 91501 970 Porto Alegre, RS, Brazil
    Ann Bot 95:799-806. 2005
    ..The aim of the present work was to analyse in more detail their geographical range in this region of overlap, to investigate intraspecific genetic variability and phylogeographic structure, and to search for possible hybrids...
  97. pmc Differential gene expression in an elite hybrid rice cultivar (Oryza sativa, L) and its parental lines based on SAGE data
    Shuhui Song
    Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China
    BMC Plant Biol 7:49. 2007
    ....
  98. ncbi Contrasting genetic structure of adults and progeny in a Louisiana iris hybrid population
    R Scott Cornman
    Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
    Evolution 58:2669-81. 2004
    ....
  99. pmc Gene expression analysis of the ovary of hybrid females of Xenopus laevis and X. muelleri
    John H Malone
    Department of Biology, The University of Texas Arlington, Box 19498, Arlington, Texas, 76010, USA
    BMC Evol Biol 8:82. 2008
    ..muelleri). In this work, we examine the gene expression pattern in hybrid females of X. laevis x X. muelleri to determine if this asymmetrical pattern of expression also occurs in hybrid females...
  100. pmc Review. Lifelong commitment to the wrong partner: hybridization in ants
    Heike Feldhaar
    Lehrstuhl für Verhaltensphysiologie und Soziobiologie Zoologie II, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Philos Trans R Soc Lond B Biol Sci 363:2891-9. 2008
    ..The morphological similarity of most ant males, perhaps resulting from the lack of sexual conflict, may similarly contribute to the commoness of hybridization...
  101. ncbi Regeneration of somatic hybrids in relation to the nuclear and cytoplasmic genomes of wheat and Setaria italica
    Fengning Xiang
    School of Life Sciences, Shandong University, Jinan 250100, Shandong, China
    Genome 47:680-8. 2004
    ..These results indicate that the regeneration of hybrid plants involves not only the integration of S. italica nuclear and organellar DNA, but also the genome complementation of T1 and T2...

Research Grants102 found, 100 shown here

  1. The genetic basis of speciation in Drosphila
    H Orr; Fiscal Year: 2007
    ..Our long-term goal is to understand how animal species, including humans, arise by uncovering the genetic causes of speciation. ..
  2. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2006
    ..groups, identified by Multilocus Sequence Typing (MLST), and can be localized in the genome by comparative genetic hybridization (CGH). In order to test this hypothesis, we propose to: 1) Define the allelic diversity of 1000 S...
  3. UV CARCINOGENESIS IN NONMAMMALIAN ANIMAL MODELS
    Rodney Nairn; Fiscal Year: 1999
    ..available in genetic hybrids of the genus Xiphophorus, in which genetic factors can be manipulated through genetic hybridization of different Xiphophorus species. Recently, UV-inducible Xiphophorus melanoma models have been developed...
  4. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  5. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2005
    ..abstract_text> ..
  6. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  7. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2001
    ..The proposed research will focus on phenotypes in each of these three categories, subjecting each to a gene mapping protocol. ..
  8. The genetics of hybrid male sterility in Drosophila virilis and D. americana
    Andrea Sweigart; Fiscal Year: 2007
    ..The proposed study is relevant to public health because studies of Drosophila fertility can be applied to understanding the genetics of human fertility. ..
  9. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2007
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  10. TRANSGRESSIVE SEGREGATION, ADAPTATION, AND SPECIATION
    Loren Rieseberg; Fiscal Year: 2007
    ..The proposed work represents an important step toward understanding the contribution of hybridization to adaptive evolution and speciation. ..
  11. Molecular genetics of Drosophila hybrid lethality
    DANIEL BARBASH; Fiscal Year: 2007
    ..simulans as well as several other Drosophila species will greatly enhance both the technical feasibility and the potential impact of this proposal as a model for testing functional consequences of sequence divergence. ..
  12. Molecular genetics of Drosophila hybrid lethality
    Daniel A Barbash; Fiscal Year: 2010
    ..Understanding the consequences of the evolutionary patterns of these genes will help to reveal how species including humans maintain a functionally coherent genome. ..
  13. The genetic basis of speciation in Drosophila
    H Allen Orr; Fiscal Year: 2010
    ....
  14. The genetic basis of speciation in Drosophila
    H Orr; Fiscal Year: 2004
    ..abstract_text> ..
  15. The genetic basis of speciation in Drosophila
    H Orr; Fiscal Year: 2009
    ....
  16. Genetic Environmental Relationship Between Bone, Obesity and Leptin in Mice
    James Cheverud; Fiscal Year: 2007
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  17. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  18. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  19. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2007
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  20. Sperm recognition genes
    Julie Alipaz; Fiscal Year: 2004
    ..All female specific transcripts will be explored for their possible involvement in gametic interactions and ultimately species divergence. ..
  21. Molecular genetics of hybrid incompatibilities in Drosophila
    Daven C Presgraves; Fiscal Year: 2010
    ..Since we are concentrating on hybrid inviability, some of our work will involve characterizing previously unstudied viability-essential genes and gene interactions that have functions required in all eukaryotes, including humans. ..
  22. Genetics of reproductive isolation in Arabidopsis
    KIRSTEN BOMBLIES YANT; Fiscal Year: 2007
    ..I will also analyze the population dynamics and molecular evolution of the incompatibility alleles to ask whether they have adaptive value to the parental strains. ..
  23. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  24. Genetics Basis of Dietary Obesity in Mice
    James Cheverud; Fiscal Year: 2009
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  25. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James M Cheverud; Fiscal Year: 2010
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  26. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James M Cheverud; Fiscal Year: 2010
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  27. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2003
    ..We will test whether animals subjected to relatively poor pre- and neonatal environments respond more strongly to the high fat diet. We will map quantitative trait loci for these genetic maternal effects and their interaction with diet. ..
  28. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 2002
    ..In addition to positional cloning of the QTLs, congenic strains will be formed for each QTL and will be tested, along with the LGxSM recombinant inbred strains for a variety of obesity-related traits. ..
  29. GENETIC BASIS OF DIETARY OBESITY IN MICE
    James Cheverud; Fiscal Year: 2005
    ..This project will be the first to detect and map genes specifically affecting response to a high fat diet. ..
  30. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James Cheverud; Fiscal Year: 2007
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  31. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 1999
    ....
  32. Transposons, RNA Interference and Heterochromatin
    Robert Martienssen; Fiscal Year: 2009
    ..These genic sRNAs may be responsible for sporadic gene methylation (epialleles) in ddm1. Cancer cells have similar changes in DNA methylation, which may use the same mechanism. ..
  33. Transposons, RNA Interference and Heterochromatin
    Robert A Martienssen; Fiscal Year: 2010
    ..These genic sRNAs may be responsible for sporadic gene methylation (epialleles) in ddm1. Cancer cells have similar changes in DNA methylation, which may use the same mechanism. ..
  34. RNAi, Histone Modification and the DDB1/CPSF-like Complex Rik1
    Robert A Martienssen; Fiscal Year: 2010
    ..Transposable elements and other repeats are common to all of these genomes, and may hold the key to epigenetic mechanisms of gene regulation and chromosome function. ..
  35. The Etiology of UV-Induced Melanoma
    David Mitchell; Fiscal Year: 2007
    ..From these studies we hope to define the effective solar wavelength boundaries of melanoma, identify the class of DNA damage critical to CMM and elucidate the role of DNA repair in tumor suppression. ..
  36. Transposons, RNA Interference and Heterochromatin
    Robert Martienssen; Fiscal Year: 2006
    ..Preliminary data suggests this mechanism is conserved in Arabidopsis. We will use each system to explore the ancient role of heterochromatin in chromosome biology. ..
  37. A Drosophila model for genomic analysis of Metabolic Syndrome
    Laura Reed; Fiscal Year: 2007
    ....