genetic hybridization

Summary

Summary: The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.

Top Publications

  1. ncbi Hybrid speciation
    James Mallet
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    Nature 446:279-83. 2007
  2. ncbi The role of hybridization in evolution
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 10:551-68. 2001
  3. pmc A model-based method for identifying species hybrids using multilocus genetic data
    E C Anderson
    Department of Statistics, University of Washington, Seattle, Washington 98195, USA
    Genetics 160:1217-29. 2002
  4. ncbi Transgressive segregation, adaptation and speciation
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Heredity (Edinb) 83:363-72. 1999
  5. pmc Genomewide nonadditive gene regulation in Arabidopsis allotetraploids
    Jianlin Wang
    Department of Agronomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 172:507-17. 2006
  6. pmc Hybrid zones and the genetic architecture of a barrier to gene flow between two sunflower species
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 152:713-27. 1999
  7. ncbi Efficiency of model-based Bayesian methods for detecting hybrid individuals under different hybridization scenarios and with different numbers of loci
    Juha Pekka Vähä
    Department of Biological and Environmental Sciences, PO Box 65, FIN 00014, University of Helsinki, Finland
    Mol Ecol 15:63-72. 2006
  8. ncbi Allelic variation and heterosis in maize: how do two halves make more than a whole?
    Nathan M Springer
    Cargill Center for Microbial and Plant Genomics, Department of Plant Biology, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Genome Res 17:264-75. 2007
  9. ncbi Major ecological transitions in wild sunflowers facilitated by hybridization
    Loren H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 301:1211-6. 2003
  10. ncbi Emerging vectors in the Culex pipiens complex
    Dina M Fonseca
    Genetics Program, Smithsonian Institution, National Museum of Natural History, 3001 Connecticut Avenue N W, Washington, DC 20008 0551, USA
    Science 303:1535-8. 2004

Research Grants

  1. Standardization of HER-2/neu Tests
    Junqi Qian; Fiscal Year: 2001
  2. ELECTROPERMEABILIZATION/FUSION OF LIPID VESICLES & CELLS
    David Needham; Fiscal Year: 1993
  3. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
  4. TRANSGRESSIVE SEGREGATION, ADAPTATION, AND SPECIATION
    Loren Rieseberg; Fiscal Year: 2008
  5. Demographics and phylogeography of hybrid speciation
    JARED STRASBURG; Fiscal Year: 2007
  6. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
  7. Sperm recognition genes
    Julie Alipaz; Fiscal Year: 2004
  8. Genetics Basis of Dietary Obesity in Mice
    James Cheverud; Fiscal Year: 2009
  9. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
  10. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James M Cheverud; Fiscal Year: 2010

Detail Information

Publications271 found, 100 shown here

  1. ncbi Hybrid speciation
    James Mallet
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    Nature 446:279-83. 2007
    ..Now, new genetic evidence suggests that hybrid speciation, even without polyploidy, is more common in plants and also animals than we thought...
  2. ncbi The role of hybridization in evolution
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 10:551-68. 2001
    ..Moreover, because adaptation is via substitutions of small effect, Fisher's model does not generate the strong effects of single chromosome regions often observed in species crosses...
  3. pmc A model-based method for identifying species hybrids using multilocus genetic data
    E C Anderson
    Department of Statistics, University of Washington, Seattle, Washington 98195, USA
    Genetics 160:1217-29. 2002
    ..We demonstrate the method on allozyme data from two species of hybridizing trout, as well as on two simulated data sets...
  4. ncbi Transgressive segregation, adaptation and speciation
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Heredity (Edinb) 83:363-72. 1999
    ..These results lend credence to the view that hybridization may provide the raw material for rapid adaptation and provide a simple explanation for niche divergence and phenotypic novelty often associated with hybrid lineages...
  5. pmc Genomewide nonadditive gene regulation in Arabidopsis allotetraploids
    Jianlin Wang
    Department of Agronomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 172:507-17. 2006
    ....
  6. pmc Hybrid zones and the genetic architecture of a barrier to gene flow between two sunflower species
    L H Rieseberg
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 152:713-27. 1999
    ..These results demonstrate the utility of hybrid zones for identifying factors contributing to isolation and verify the prediction of increased resolution relative to controlled crosses...
  7. ncbi Efficiency of model-based Bayesian methods for detecting hybrid individuals under different hybridization scenarios and with different numbers of loci
    Juha Pekka Vähä
    Department of Biological and Environmental Sciences, PO Box 65, FIN 00014, University of Helsinki, Finland
    Mol Ecol 15:63-72. 2006
    ..However, separating backcrosses from purebred parental individuals requires a considerable genotyping effort (at least 48 loci), even when divergence between parental populations is high...
  8. ncbi Allelic variation and heterosis in maize: how do two halves make more than a whole?
    Nathan M Springer
    Cargill Center for Microbial and Plant Genomics, Department of Plant Biology, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Genome Res 17:264-75. 2007
    ..Variation for the presence of genes, the presence of novel beneficial alleles, and modified levels of gene expression in hybrids may all contribute to the heterotic phenotypes...
  9. ncbi Major ecological transitions in wild sunflowers facilitated by hybridization
    Loren H Rieseberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 301:1211-6. 2003
    ..The same combinations of parental chromosomal segments required to generate extreme phenotypes in synthetic hybrids also occurred in ancient hybrids. Thus, hybridization facilitated ecological divergence in sunflowers...
  10. ncbi Emerging vectors in the Culex pipiens complex
    Dina M Fonseca
    Genetics Program, Smithsonian Institution, National Museum of Natural History, 3001 Connecticut Avenue N W, Washington, DC 20008 0551, USA
    Science 303:1535-8. 2004
    ..Such hybrids between human-biters and bird-biters may be the bridge vectors contributing to the unprecedented severity and range of the West Nile virus epidemic in North America...
  11. ncbi Genomic plasticity and the diversity of polyploid plants
    A R Leitch
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
    Science 320:481-3. 2008
    ..This process has been a major driving force behind the divergence of the angiosperms and their biodiversity...
  12. ncbi Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 423:715-9. 2003
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
  13. ncbi Speciation via introgressive hybridization in East African cichlids?
    W Salzburger
    Department of Zoology and Limnology, University of Innsbruck, Technikerstrasse 25, A 6020 Innsbruck, Austria
    Mol Ecol 11:619-25. 2002
    ..Hence, our finding displays another mode of speciation in cichlid fishes. The increase of genetic and phenotypic diversity due to hybridization may contribute to the uniquely rapid pace of speciation in cichlids...
  14. ncbi A yeast hybrid provides insight into the evolution of gene expression regulation
    Itay Tirosh
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Science 324:659-62. 2009
    ..These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization...
  15. ncbi Differential patterns of introgression across the X chromosome in a hybrid zone between two species of house mice
    Bret A Payseur
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, Arizona 85721, USA
    Evolution 58:2064-78. 2004
    ..This study highlights the utility of natural populations of hybrids for mapping speciation genes and suggests that the middle of the X chromosome may be important for reproductive isolation between species of house mice...
  16. pmc A genomic view of introgression and hybrid speciation
    Eric J Baack
    Department of Botany, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Genet Dev 17:513-8. 2007
    ....
  17. pmc Dominance, epistasis and the genetics of postzygotic isolation
    M Turelli
    Section of Evolution and Ecology and Center for Population Biology, University of California, Davis 95616, USA
    Genetics 154:1663-79. 2000
    ..Such incompatibilities are common in Drosophila species crosses, and their consequences in male- vs. female-heterogametic taxa may explain the pattern of exceptions to Haldane's rule...
  18. ncbi The hidden side of invasions: massive introgression by local genes
    Mathias Currat
    Computational and Molecular Population Genetics Laboratory, Institute of Zoology, University of Bern, Baltzerstrasse 6, 3012 Berne, Switzerland
    Evolution 62:1908-20. 2008
    ..Our results imply that speciation genes can be identified by comparing genomes of interfertile native and invading species pairs...
  19. pmc Evolution and expression of homeologous loci in Tragopogon miscellus (Asteraceae), a recent and reciprocally formed allopolyploid
    Jennifer A Tate
    Department of Botany, University of Florida, Gainesville, Florida 32611, USA
    Genetics 173:1599-611. 2006
    ..Synthetic F(1) hybrids between putative diploid progenitors are additive of their parental genomes, suggesting that polyploidization rather than hybridization induces genomic changes in Tragopogon...
  20. pmc Sequence elimination and cytosine methylation are rapid and reproducible responses of the genome to wide hybridization and allopolyploidy in wheat
    H Shaked
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    Plant Cell 13:1749-59. 2001
    ....
  21. ncbi Speciation in reverse: morphological and genetic evidence of the collapse of a three-spined stickleback (Gasterosteus aculeatus) species pair
    E B Taylor
    Department of Zoology and Biodiversity Research Centre, University of British Columbia, 6270 University Blvd, Vancouver, BC V6T 1Z4, Canada
    Mol Ecol 15:343-55. 2006
    ..Although the precise mechanism(s) responsible for elevated hybridization in the lake is unknown, the demise of the Enos Lake species pair follows the appearance of an exotic crayfish, Pascifasticus lenisculus, in the early 1990s...
  22. ncbi Comparative expression profiling in meristems of inbred-hybrid triplets of maize based on morphological investigations of heterosis for plant height
    Anna Uzarowska
    Department of Plant Breeding, Technical University of Munich, Freising, Germany
    Plant Mol Biol 63:21-34. 2007
    ..Quantitative RT-PCR was applied in order to validate microarray results. The role of the differentially expressed genes in relation to heterosis for PHT is discussed...
  23. ncbi Hybridization and adaptive mate choice in flycatchers
    T Veen
    Department of Animal Ecology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden
    Nature 411:45-50. 2001
    ..Apparent hybridization may thus represent adaptive mate choice under some circumstances...
  24. pmc Evidence of hybridity in invasive watermilfoil (Myriophyllum) populations
    Michael L Moody
    Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs 06269 3043, USA
    Proc Natl Acad Sci U S A 99:14867-71. 2002
    ..These observations suggest that invasiveness in these aggressive aquatic weeds may be linked to heterosis maintained by vegetative propagation...
  25. pmc Genetic analysis of variation in gene expression in Arabidopsis thaliana
    Marnik Vuylsteke
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, B 9052 Gent, Belgium
    Genetics 171:1267-75. 2005
    ..Further advances in the genetic analysis of gene expression variation may contribute to a better understanding of its role in affecting quantitative trait variation at the phenotypic level...
  26. ncbi Dynamics of polyploid formation in Tragopogon (Asteraceae): recurrent formation, gene flow, and population structure
    V Vaughan Symonds
    Florida Museum of Natural History, University of Florida, Gainesville, Florida 32611, USA
    Evolution 64:1984-2003. 2010
    ..Our data also indicate a lack of gene flow among polyploid plants of independent origin, even when they co-occur, suggesting potential reproductive barriers among separate lineages in both polyploid species...
  27. ncbi Contrasting patterns of mitochondrial DNA and microsatellite introgressive hybridization between lineages of lake whitefish (Coregonus clupeaformis); relevance for speciation
    G Lu
    GIROQ, , , Ste-Foy, , Canada G1K 7P4
    Mol Ecol 10:965-85. 2001
    ..Thus, each lake may be viewed as a different temporal snapshot taken throughout the gradual process of speciation...
  28. pmc Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house mice
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Evolution 62:50-65. 2008
    ..These data build on previous studies of speciation in house mice and show that the genetic basis of hybrid male sterility is fairly complex, even at this early stage of divergence...
  29. ncbi Transcriptome shock after interspecific hybridization in senecio is ameliorated by genome duplication
    Matthew J Hegarty
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    Curr Biol 16:1652-9. 2006
    ..cambrensis and this altered expression pattern is maintained in subsequent generations. These findings indicate that hybridization and polyploidization have immediate yet distinct effects on large-scale patterns of gene expression...
  30. ncbi Mobilization of the active MITE transposons mPing and Pong in rice by introgression from wild rice (Zizania latifolia Griseb.)
    Xiaohui Shan
    Laboratory of Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
    Mol Biol Evol 22:976-90. 2005
    ..In addition, we report an atypical behavior of mPing/Pong mobilization in these lines, i.e., the exclusive absence of footprints after excision...
  31. ncbi Identification of differentially expressed genes in leaf and root between wheat hybrid and its parental inbreds using PCR-based cDNA subtraction
    Yingyin Yao
    Department of Plant Genetics and Breeding, Key Laboratory of Crop Genomics and Genetic Improvement, Ministry of Agriculture Beijing, China Agricultural University, 100094 Beijing, China
    Plant Mol Biol 58:367-84. 2005
    ..2%). And it was concluded that the genes differentially expressed between hybrids and their parents involved in diverse physiological process pathway, which might be responsible for the observed heterosis...
  32. ncbi Genetic rescue of inviable hybrids between Drosophila melanogaster and its sibling species
    P Hutter
    Nature 327:331-3. 1987
    ..melanogaster females and males of its three closest relatives. The study of this locus may shed light on the genetic control of both speciation and development...
  33. ncbi Natural selection for salt tolerance quantitative trait loci (QTLs) in wild sunflower hybrids: implications for the origin of Helianthus paradoxus, a diploid hybrid species
    C Lexer
    Department of Biology, Jordan Hall 142, 1001 East Third Street, Indiana University, Bloomington, IN 47405, USA
    Mol Ecol 12:1225-35. 2003
    ..paradoxus. Finally, selection coefficients of +0.126, -0.084 and -0.094 for the three survivorship QTLs, respectively, are sufficiently large to account for establishment of new, homoploid hybrid species...
  34. ncbi The likelihood of homoploid hybrid speciation
    C A Buerkle
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Heredity (Edinb) 84:441-51. 2000
    ..Our results confirmed the importance of the combination of factors that had been emphasized in verbal models and illustrate the trade-off between the frequency at which hybrid species arise and the genetic integrity of incipient species...
  35. ncbi Complete mitochondrial DNA replacement in a Lake Tanganyika cichlid fish
    B Nevado
    Department Vertebrates, Royal Belgian Institute of Natural Sciences, 1000 Brussels, Belgium
    Mol Ecol 18:4240-55. 2009
    ..callipterus mtDNA lineages, probably still during the water level low stand, and that subsequently the invading mtDNA lineage spread throughout the lake...
  36. ncbi Natural hybridization and the evolution of domesticated, pest and disease organisms
    Michael L Arnold
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Mol Ecol 13:997-1007. 2004
    ..I focus on the effects from genetic exchange that may lead to the acquisition of novel phenotypes and thus increase the beneficial or detrimental (to human populations) aspects of the various taxa...
  37. ncbi Speciation reversal and biodiversity dynamics with hybridization in changing environments
    Ole Seehausen
    Center of Ecology, Evolution and Biogeochemistry, Swiss Institute for Environmental Sciences and Technology EAWAG, Seestrasse 79, 6047 Kastanienbaum, Switzerland
    Mol Ecol 17:30-44. 2008
    ..Since heterogeneity of natural environments is rapidly deteriorating in most biomes, the evolutionary ecology of speciation reversal ought to be fully integrated into conservation biology...
  38. ncbi Weed evolution after crop gene introgression: greater survival and fecundity of hybrids in a new environment
    Lesley G Campbell
    Ecol Lett 9:1198-209. 2006
    ..270% greater lifetime fecundity and c. 22% greater survival than wild plants in CA. Our results support the hypothesis that crop-wild hybridization may create genotypes with the potential to displace parental taxa in new environments...
  39. ncbi Facultative mate choice drives adaptive hybridization
    Karin S Pfennig
    Department of Biology, Campus Box 3280, Coker Hall, University of North Carolina, Chapel Hill, NC 27599, USA
    Science 318:965-7. 2007
    ..Thus, when the benefits of mate choice vary, females may radically alter their mate selection in response to their own phenotype and their environment, even to the point of choosing males of other species...
  40. ncbi Hybridization in the recent past
    Peter R Grant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544 1003, USA
    Am Nat 166:56-67. 2005
    ....
  41. ncbi Quantitative trait analysis of seed yield and other complex traits in hybrid spring rapeseed (Brassica napus L.): 2. Identification of alleles from unadapted germplasm
    Joshua A Udall
    Plant Breeding and Plant Genetics Program, and Department of Agronomy, University of Wisconsin, Madison, WI 53706, USA
    Theor Appl Genet 113:597-609. 2006
    ..In this QTL region, a chromosome rearrangement was identified in P1804, which may have affected seed yield...
  42. pmc Genetic dissection of an elite rice hybrid revealed that heterozygotes are not always advantageous for performance
    J P Hua
    National Key Laboratory of Crop Genetic Improvement, National Center of Crop Molecular Breeding, Huazhong Agricultural University, Wuhan 430070, China
    Genetics 162:1885-95. 2002
    ..It was concluded that heterozygotes were not necessarily advantageous for trait performance even among genotypes derived from such a highly heterotic hybrid...
  43. ncbi Ancient hybridization and mitochondrial capture between two species of chipmunks
    Jeffrey M Good
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, AZ 85721, USA
    Mol Ecol 17:1313-27. 2008
    ..Our findings challenge long-standing assumptions on patterns of reproductive isolation in chipmunks and suggest that there may be other examples of hybridization among the 23 species of Tamias that occur in western North America...
  44. ncbi Bayesian analyses of admixture in wild and domestic cats (Felis silvestris) using linked microsatellite loci
    R Lecis
    Istituto Nazionale per la Fauna Fauna Selvatica, via Ca Fornacetta 9, 40064 Ozzano dell Emilia Bologna, Italy
    Mol Ecol 15:119-31. 2006
    ..Inferred recombination events led to identify the population of origin of chromosomal segments, suggesting that admixture mapping experiments can be designed also in wild populations...
  45. pmc Serial analysis of gene expression study of a hybrid rice strain (LYP9) and its parental cultivars
    Jingyue Bao
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Plant Physiol 138:1216-31. 2005
    ..Our study adds a new set of data crucial for the understanding of molecular mechanisms of heterosis and gene regulation networks of the cultivated rice...
  46. ncbi Hybrid speciation in experimental populations of yeast
    Duncan Greig
    The Galton Laboratory, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 298:1773-5. 2002
    ..Extensive karyotypic changes (tetrasomy) were observed in the hybrids, although genic incompatibilities accounted for 50% of the variation in self-fertility...
  47. pmc Inheritance patterns of transcript levels in F1 hybrid mice
    Xiangqin Cui
    Department of Biostatistics, Section on Statistical Genetics, Department of Medicine, Genetic and Translational Medicine Division, University of Alabama, Alabama 35294, USA
    Genetics 174:627-37. 2006
    ..In addition, we identified 314 transcripts with expression levels that differ between the reciprocal F1 animals. These genes may be related to maternal effect...
  48. ncbi Variable patterns of introgression in two sculpin hybrid zones suggest that genomic isolation differs among populations
    A W Nolte
    Max Planck Institute for Evolutionary Biology, August Thienemann Strasse 2, 24306 Plön, Germany
    Mol Ecol 18:2615-27. 2009
    ..In the future, data from mapped genetic markers and on variation of ecological factors will provide additional insights into the contribution of these factors to variation in the evolutionary consequences of hybridization...
  49. pmc The ecological genetics of homoploid hybrid speciation
    B L Gross
    Department of Biology, 1001 E 3rd Street, Jordan Hall 142, Indiana University, Bloomington, IN 47405, USA
    J Hered 96:241-52. 2005
    ..Overall, theory and empirical evidence gathered to date suggest that ecological selection is a major factor promoting homoploid hybrid speciation, with the strongest evidence coming from genetic studies...
  50. pmc Bayesian inference of species hybrids using multilocus dominant genetic markers
    Eric C Anderson
    Fisheries Ecology Division, Southwest Fisheries Science Center, Santa Cruz, CA 95060, USA
    Philos Trans R Soc Lond B Biol Sci 363:2841-50. 2008
    ..Discriminating between pure-bred and non-pure (hybrid) individuals, however, is shown to be much easier, requiring perhaps as few as 10 dominant markers, even from relatively weakly diverged species...
  51. ncbi Adaptation and selection in the Senecio (Asteraceae) hybrid zone on Mount Etna, Sicily
    Adrian C Brennan
    Sir Harold Mitchell Building, School of Biology, University of St Andrews, St Andrews, Fife, UK
    New Phytol 183:702-17. 2009
    ..These results support the hypothesis that extrinsic and intrinsic selection against hybrids maintains the hybrid zone and species distinctiveness despite gene flow between the two Senecio species on Mount Etna...
  52. ncbi Stress and domestication traits increase the relative fitness of crop-wild hybrids in sunflower
    Kristin L Mercer
    Applied Plant Sciences Program, University of Minnesota, 411 Borlaug Hall, 1991 Upper Buford Circle, St Paul, MN 55108, USA
    Ecol Lett 10:383-93. 2007
    ..Rigorous assessment of how particular genotypes, phenotypes, and environments affect introgression will improve risk assessment for transgenic crops...
  53. pmc Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus
    Daniel A Barbash
    Section of Evolution and Ecology, University of California, Davis, USA
    PLoS Biol 2:e142. 2004
    ..Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles...
  54. ncbi A rapidly evolving homeobox at the site of a hybrid sterility gene
    C T Ting
    Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
    Science 282:1501-4. 1998
    ..Such rapid sequence divergence is driven by positive selection and may contribute to reproductive isolation...
  55. ncbi Rates of evolution of hybrid inviability in birds and mammals
    Benjamin M Fitzpatrick
    Center for Population Biology and Section of Evolution and Ecology, University of California, Davis, California 95616, USA
    Evolution 58:1865-70. 2004
    ..I briefly discuss this and other potential explanations...
  56. pmc Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression
    Rita M Graze
    Genetics Institute, Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 3261 3610, USA
    Genetics 183:547-61, 1SI-21SI. 2009
    ..In addition, two genes, with critical roles in sex determination and micro RNA processing, Sxl and loqs, were identified as misexpressed in hybrid female heads, potentially contributing to hybrid incompatibility...
  57. ncbi Complex hybridization dynamics between golden-winged and blue-winged warblers (Vermivora chrysoptera and Vermivora pinus) revealed by AFLP, microsatellite, intron and mtDNA markers
    R Vallender
    Fuller Evolutionary Biology Program, Laboratory of Ornithology, Cornell University, 159 Sapsucker Woods Road, Ithaca, NY 14850, USA
    Mol Ecol 16:2017-29. 2007
    ....
  58. ncbi Rapid radiation, ancient incomplete lineage sorting and ancient hybridization in the endemic Lake Tanganyika cichlid tribe Tropheini
    Stephan Koblmüller
    Department of Zoology, Karl Franzens University Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Mol Phylogenet Evol 55:318-34. 2010
    ..A large degree of correspondence between AFLP clustering and trophic types indicated fewer cases of parallel evolution of trophic ecomorphology than previously inferred from mitochondrial data...
  59. ncbi Epigenetic, transposon and small RNA determinants of hybrid dysfunctions
    P Michalak
    Department of Biology, The University of Texas Arlington, Arlington, TX 76019 0498, USA
    Heredity (Edinb) 102:45-50. 2009
    ..The review offers a handful of glimpses into these complex dynamics...
  60. ncbi Leaky prezygotic isolation and porous genomes: rapid introgression of maternally inherited DNA
    Kai M A Chan
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544 1003, USA
    Evolution 59:720-9. 2005
    ..These findings suggest that we should use extreme caution when interpreting single gene genealogies as species phylogenies, especially for cpDNA and mtDNA...
  61. ncbi Natural selection influences AFLP intraspecific genetic variability and introgression patterns in Atlantic eels
    P A Gagnaire
    Institut des Sciences de l Evolution ISEM UMR 5554 CNRS UMII, Universite de Montpellier II, Place E Bataillon, Montpellier Cedex 5, France
    Mol Ecol 18:1678-91. 2009
    ....
  62. ncbi Conspecific sperm precedence in sister species of Drosophila with overlapping ranges
    Audrey S Chang
    Department of Ecology and Evolution, The University of Chicago, 1101 E 57 Street, Chicago, Illinois 60637, USA
    Evolution 58:781-9. 2004
    ..These results suggest that noncompetitive and competitive gametic isolating barriers may contribute to reproductive isolation between D. yakuba and D. santomea...
  63. pmc The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids
    D A Barbash
    Department of Genetics, University of Cambridge, United Kingdom
    Genetics 154:1747-71. 2000
    ..melanogaster mothers. Implications of our findings for understanding Haldane's rule-the observation that hybrid breakdown is often specific to the heterogametic sex-are also discussed...
  64. ncbi Correlation between parental transcriptome and field data for the characterization of heterosis in Zea mays L
    Alexander Thiemann
    Biocenter Klein Flottbek, University of Hamburg, 22609 Hamburg, Germany
    Theor Appl Genet 120:401-13. 2010
    ..The phenomenon of heterosis was characterized by the over- and underrepresentation of specific GO terms among heterosis-correlated genes...
  65. pmc The ubiquitous mountain hare mitochondria: multiple introgressive hybridization in hares, genus Lepus
    Paulo C Alves
    Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
    Philos Trans R Soc Lond B Biol Sci 363:2831-9. 2008
    ..Such high levels of introgressive hybridization should discourage attempts to revise hare taxonomy based solely on mtDNA...
  66. pmc Hybrid sterility, Haldane's rule and speciation in Heliconius cydno and H. melpomene
    Russell E Naisbit
    The Galton Laboratory, Department of Biology, University College London, London NW1 2HE, United Kingdom
    Genetics 161:1517-26. 2002
    ..The effect of female sterility is comparable to that of selection against non-mimetic hybrids, while mate choice forms a much stronger barrier to gene transfer...
  67. ncbi Inferences from a rapidly moving hybrid zone
    Kanchon K Dasmahapatra
    Department of Biology, University College London, United Kingdom
    Evolution 56:741-53. 2002
    ..Hybrid zone movement has rarely been considered likely in the past, but our results show that it may be more important in biogeography and evolution than generally realized...
  68. pmc Aneuploidy and genetic variation in the Arabidopsis thaliana triploid response
    Isabelle M Henry
    Department of Biology, University of Washington, Seattle, Washington 98195 5325, USA
    Genetics 170:1979-88. 2005
    ..Thus, genetic variation was subject to selection contingent on the final ploidy and possibly acting during the protracted aneuploid phase...
  69. ncbi Interspecific hybridization in plant-associated fungi and oomycetes: a review
    C L Schardl
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546 0091, USA
    Mol Ecol 12:2861-73. 2003
    ..Hybrid mutualists may also be better adapted to new hosts and can provide greater or more diverse benefits to host plants...
  70. pmc Hybrid lethal systems in the Drosophila melanogaster species complex. II. The Zygotic hybrid rescue (Zhr) gene of D. melanogaster
    K Sawamura
    Department of Genetics, Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka, Japan
    Genetics 133:307-13. 1993
    ..A model is proposed to explain the genetic mechanisms of hybrid lethalities as well as the evolutionary pathways...
  71. ncbi Wolbachia-induced incompatibility precedes other hybrid incompatibilities in Nasonia
    S R Bordenstein
    Department of Biology, The University of Rochester, New York 14627, USA
    Nature 409:707-10. 2001
    ....
  72. ncbi The maintenance of reproductive isolation in a mosaic hybrid zone between the fire-bellied toads Bombina bombina and B. variegata
    T H Vines
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
    Evolution 57:1876-88. 2003
    ..The hybrid zone may be approaching a state in which the gene pools are homogenized at all but the selected loci, not dissimilar from an early stage of sympatric divergence...
  73. ncbi A role for the mismatch repair system during incipient speciation in Saccharomyces
    D Greig
    The Galton Laboratory, Department of Biology, University College London, London, UK
    J Evol Biol 16:429-37. 2003
    ..We show that these crosses are partially sterile and present evidence that the mismatch repair system is largely responsible for this sterility...
  74. ncbi Barrier to gene flow between two ecologically divergent Populus species, P. alba (white poplar) and P. tremula (European aspen): the role of ecology and life history in gene introgression
    C Lexer
    Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3DS, UK
    Mol Ecol 14:1045-57. 2005
    ..alba N(e)c. 500-550; P. tremula N(e)c. 550-700). Our results indicate that hybrid zones will be valuable tools for studying the genetic architecture of the barrier to gene flow between these two ecologically divergent Populus species...
  75. pmc Genetics of postzygotic isolation in Eucalyptus: whole-genome analysis of barriers to introgression in a wide interspecific cross of Eucalyptus grandis and E. globulus
    Alexander A Myburg
    Department of Forestry, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 166:1405-18. 2004
    ....
  76. pmc Intra-individual polymorphism in diploid and apomictic polyploid hawkweeds (Hieracium, Lactuceae, Asteraceae): disentangling phylogenetic signal, reticulation, and noise
    Judith Fehrer
    Institute of Botany, Academy of Sciences of the Czech Republic, Pruhonice, Czech Republic
    BMC Evol Biol 9:239. 2009
    ..Concentrating on the supposed major evolutionary units, we used nuclear ribosomal (ETS) and chloroplast (trnT-trnL) sequences in order to disentangle the phylogenetic relationships and to infer the origins of the polyploids...
  77. ncbi The accumulation of reproductive incompatibilities in African cichlid fish
    Rike B Stelkens
    Department of Ecology and Evolution, University of Lausanne, Biophore, CH 1015 Lausanne, Switzerland
    Evolution 64:617-33. 2010
    ..By quantifying the capacity to produce viable hybrids between allopatric, distantly related lineages our results also provide an upper divergence time limit for the "hybrid swarm origin" model of adaptive radiation...
  78. ncbi The rise and fall of the mountain hare (Lepus timidus) during Pleistocene glaciations: expansion and retreat with hybridization in the Iberian Peninsula
    J Melo-Ferreira
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
    Mol Ecol 16:605-18. 2007
    ..Whether a similar scenario explains the introgression into Iberian L. europaeus remains unclear but it is possible that it hybridized with already introgressed L. granatensis...
  79. pmc Asymmetrical reinforcement and Wolbachia infection in Drosophila
    John Jaenike
    Department of Biology, University of Rochester, Rochester, New York, USA
    PLoS Biol 4:e325. 2006
    ..Given the widespread occurrence of Wolbachia among insects, it thus appears that there are multiple ways by which these endosymbionts may directly and indirectly contribute to reproductive isolation and speciation...
  80. ncbi From clonal to sexual hybrids: genetic recombination via triploids in all-hybrid populations of water frogs
    Ditte G Christiansen
    Ecology, Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Evolution 63:1754-68. 2009
    ..esculentus calls for a change of the conventional view of hybridogens as clonally reproducing diploids. Rather, hybridogens can be independent sexually reproducing units with an evolutionary potential...
  81. ncbi Genetic and epigenetic consequences of recent hybridization and polyploidy in Spartina (Poaceae)
    Armel Salmon
    UMR 118 INRA Agrocampus Rennes, Amelioration des Plantes et Biotechnologies Vegetales, Station de Génétique et Amélioration des Plantes, F 35653 Le Rheu, France
    Mol Ecol 14:1163-75. 2005
    ..Hybridization rather than genome doubling seems to have triggered most of the methylation changes observed in Spartina anglica...
  82. ncbi Genetic evidence for complex speciation of humans and chimpanzees
    Nick Patterson
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 441:1103-8. 2006
    ..These unexpected features would be explained if the human and chimpanzee lineages initially diverged, then later exchanged genes before separating permanently...
  83. ncbi Species relative abundance and direction of introgression in oaks
    O Lepais
    INRA, UMR 1202 BIOGECO, Cestas, France
    Mol Ecol 18:2228-42. 2009
    ..In addition, we demonstrate a strong impact of species abundance on both hybridisation rate and introgression directionality...
  84. pmc Adaptation by introgression
    Michael L Arnold
    Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
    J Biol 8:82. 2009
    ..A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals the mosaic nature of introgression, which is probably caused by a combination of selection and demography...
  85. ncbi Genetics and the fitness of hybrids
    J M Burke
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Genet 35:31-52. 2001
    ..In contrast, increased hybrid fitness can be most readily explained through the segregation of additive genetic factors, with epistasis playing a more limited role...
  86. pmc Early events in speciation: polymorphism for hybrid male sterility in Drosophila
    Laura K Reed
    Department of Ecology and Evolutionary Biology and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 101:9009-12. 2004
    ..Because male sterility factors in hybrids between these species are not yet fixed within D. mojavensis, this system provides an invaluable opportunity to characterize the genetics of reproductive isolation at an early stage...
  87. ncbi Combined use of maternal, paternal and bi-parental genetic markers for the identification of wolf-dog hybrids
    C Vila
    Department of Evolutionary Biology, Uppsala University, Sweden
    Heredity (Edinb) 90:17-24. 2003
    ..This finding confirms that inter-specific hybridization between wolves and dogs can occur in natural wolf populations. A possible correlation between hybridization and wolf population density and disturbance deserves further research...
  88. pmc Hybridization rapidly reduces fitness of a native trout in the wild
    Clint C Muhlfeld
    US Geological Survey, Northern Rocky Mountain Science Center, Glacier National Park, West Glacier, MT 59936, USA
    Biol Lett 5:328-31. 2009
    ..This outbreeding depression suggests that even low levels of admixture may have negative effects on fitness in the wild and that policies protecting hybridized populations may need reconsideration...
  89. ncbi Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila
    Nicholas J Brideau
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 314:1292-5. 2006
    ..Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene...
  90. ncbi Song similarity predicts hybridization in flycatchers
    A Qvarnström
    Animal Ecology, Department of Ecology and Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    J Evol Biol 19:1202-9. 2006
    ..45% of 484 pairs; predicted 19.5%). Our results support the suggestion that song functions as the most important prezygotic isolation mechanism in many birds...
  91. ncbi An anomalous hybrid zone in Drosophila
    Ana Llopart
    Department of Biological Sciences, University of Iowa, 215 Biology Building BB, Iowa City, Iowa 52242, USA
    Evolution 59:2602-7. 2005
    ..Third, there is a puzzling absence of hybrid females. We suggest several tentative explanations for the anomalies associated with this hybrid zone, but for the present they remain a mystery...
  92. ncbi Genes and speciation
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Genet 5:114-22. 2004
  93. pmc Extended Newick: it is time for a standard representation of phylogenetic networks
    Gabriel Cardona
    Department of Mathematics and Computer Science, University of the Balearic Islands, Palma de Mallorca, Spain
    BMC Bioinformatics 9:532. 2008
    ....
  94. pmc Introduction. Extent, processes and evolutionary impact of interspecific hybridization in animals
    Klaus Schwenk
    Department of Ecology and Evolution, J W Goethe University Frankfurt am Main, 60054 Frankfurt am Main, Germany
    Philos Trans R Soc Lond B Biol Sci 363:2805-11. 2008
    ..Here we provide firstly a historic perspective of hybridization research, secondly a novel attempt to assess the extent of hybridization among animals and thirdly an overview of the reviews and case studies presented in this theme issue...
  95. pmc Plant speciation
    Loren H Rieseberg
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 317:910-4. 2007
    ..Finally, species richness in plants is correlated with many biological and geohistorical factors, most of which increase ecological opportunities...
  96. ncbi Gene transposition as a cause of hybrid sterility in Drosophila
    John P Masly
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 313:1448-50. 2006
    ..simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution...
  97. ncbi Evidence for bimodal hybrid zones between two species of char (Pisces: Salvelinus) in northwestern North America
    Z Redenbach
    Department of Zoology, Native Fish Research Group, University of British Columbia, Vancouver, BC, Canada
    J Evol Biol 16:1135-48. 2003
    ..These traits may limit interspecific pairings because of size assortative pairing and size-dependent reproductive habitat use...
  98. pmc Classical genetic and quantitative trait loci analyses of heterosis in a maize hybrid between two elite inbred lines
    Elisabetta Frascaroli
    Department of Agroenvironmental Sciences and Technologies, University of Bologna, 40127 Bologna, Italy
    Genetics 176:625-44. 2007
    ..Some chromosome regions presented overlaps of overdominant QTL for SW, PH, NK, and GY, suggesting pleiotropic effects on overall plant vigor...
  99. ncbi Adaptive gamete-recognition divergence in a hybridizing Mytilus population
    Stevan A Springer
    Department of Biosciences, Behavioural Ecology Research Group, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada
    Evolution 61:772-83. 2007
    ..edulis in the East Atlantic, drove the divergence of Lysin-M7 in M. galloprovincialis...
  100. ncbi Parent-dependent loss of gene silencing during interspecies hybridization
    Caroline Josefsson
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 16:1322-8. 2006
    ..We propose that the dosage-dependent regulation of chromatin could be a universal phenomenon affecting lethality in interspecies hybrids...
  101. ncbi Prevalence of interspecific hybrids amongst asexual fungal endophytes of grasses
    C D Moon
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Mol Ecol 13:1455-67. 2004
    ..Therefore, the abundance of hybrid species among grass endophytes, and their prevalence in many host populations suggests a selective advantage of hybridization for the mutualistic endophytes...

Research Grants49

  1. Standardization of HER-2/neu Tests
    Junqi Qian; Fiscal Year: 2001
    ..and calibrators for quantitative immunohistochemistry, fluorescence in situ hybridization, and various genetic hybridization procedures...
  2. ELECTROPERMEABILIZATION/FUSION OF LIPID VESICLES & CELLS
    David Needham; Fiscal Year: 1993
    ..These fundamental studies will find direct application in newly developing areas of biomedical and biochemical technologies, such as drug and hemoglobin encapsulation, antibody loading and genetic hybridization.
  3. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  4. TRANSGRESSIVE SEGREGATION, ADAPTATION, AND SPECIATION
    Loren Rieseberg; Fiscal Year: 2008
    ..The proposed work represents an important step toward understanding the contribution of hybridization to adaptive evolution and speciation. ..
  5. Demographics and phylogeography of hybrid speciation
    JARED STRASBURG; Fiscal Year: 2007
    ..abstract_text> ..
  6. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  7. Sperm recognition genes
    Julie Alipaz; Fiscal Year: 2004
    ..All female specific transcripts will be explored for their possible involvement in gametic interactions and ultimately species divergence. ..
  8. Genetics Basis of Dietary Obesity in Mice
    James Cheverud; Fiscal Year: 2009
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  9. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  10. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James M Cheverud; Fiscal Year: 2010
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  11. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James M Cheverud; Fiscal Year: 2010
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  12. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 2002
    ..In addition to positional cloning of the QTLs, congenic strains will be formed for each QTL and will be tested, along with the LGxSM recombinant inbred strains for a variety of obesity-related traits. ..
  13. Epigenetic Regulation of Gene Expression
    Robert Martienssen; Fiscal Year: 2003
    ..It is in a cross-disciplinary environment such as this that intellectual leaps occur and innovative ideas flourish. ..
  14. Transcriptional and genic basis of incipient speciation
    Chung I Wu; Fiscal Year: 2008
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  15. Noninvasive monitoring of physiological parameters in mice
    LARRY SANFORD; Fiscal Year: 2008
    ..The proposed applications have particular significance for studies of behavior and sleep. [unreadable] [unreadable] [unreadable]..
  16. CMMI Human Subject Research Enhancement Program
    David Goldenberg; Fiscal Year: 2002
    ..3.) Provide travel expenses and educational materials for IRB members, investigators, and Regulatory Affairs Office personnel to attend meetings for educational enhancement. ..
  17. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2008
    ..abstract_text> ..
  18. Evolution of L1sw Retrotransposons in Teleost Fishes
    David Duvernell; Fiscal Year: 2002
    ..abstract_text> ..
  19. ENHANCED DEVELOPMENT OF THE XIPHOPHORUS MODEL SYSTEM
    RONALD WALTER; Fiscal Year: 2001
    ....
  20. Studies on Influenza B Virus BM2 Protein Ion Channel
    LAWRENCE PINTO; Fiscal Year: 2009
    ....
  21. PHENOTYPICAL EXPRESSION OF ANXIETY AND SLEEP
    LARRY SANFORD; Fiscal Year: 2009
    ....
  22. The Etiology of UV-Induced Melanoma
    David L Mitchell; Fiscal Year: 2010
    ..From these studies we hope to define the effective solar wavelength boundaries of melanoma, identify the class of DNA damage critical to CMM and elucidate the role of DNA repair in tumor suppression. ..
  23. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....
  24. THE XIPHOPHORUS GENETIC STOCK CENTER
    RONALD WALTER; Fiscal Year: 2006
    ..abstract_text> ..
  25. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2010
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..
  26. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  27. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  28. NEUROBIOLOGICAL EFFECTS OF ALTERED MOTOR CONTROL IN REM
    LARRY SANFORD; Fiscal Year: 2001
    ..These studies may lead to a better understanding of disorders of REM, such as REM behavior disorder, which, like REM-A, is characterized by overt behavior during sleep. ..
  29. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..Such understanding may provide insight that could lead to improved therapies and improved prognosis for infectious diseases. ..
  30. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
  31. 11th & 12th Conference on Cancer Therapy with Antibodies and Immunoconjugates
    David Goldenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. The Cichlid Dentition Integrates Tooth Number and Tooth Shape
    JEFFREY STREELMAN; Fiscal Year: 2007
    ..Results may identify novel therapeutic targets for human dental disorders that warrant further testing in mammalian models. [unreadable] [unreadable] [unreadable]..
  33. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  34. Cryptococcus gatti mating 1oci; mapping and gene study
    Vishnu Chaturvedi; Fiscal Year: 2004
    ..abstract_text> ..
  35. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  36. 9/10TH Conf./Cancer Therapy/Antibody/Immunoconjugates
    David Goldenberg; Fiscal Year: 2004
    ..The conference chairman, Dr. Goldenberg, has secured two outstanding scientists as co-chairmen, Drs. Ralph Reisfeld (Scripps) and Edward Sausville (NCI). ..
  37. Protein Self-Assembly in Model Microorganisms
    James Hu; Fiscal Year: 2004
    ..cerevisiae and E. coli) and important human pathogens (M. tuberculosis and A. fumigatus), and new drug targets based on protein-protein interactions. ..
  38. Parenchymal/Stem Cell Pathways for Salivary Gland Repair
    Robert Redman; Fiscal Year: 2003
    ..abstract_text> ..
  39. Self recognition and signaling in plant reproduction
    JUNE NASRALLAH; Fiscal Year: 2005
    ..abstract_text> ..
  40. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  41. Relevance of Herbal Products in Transplantation
    Dilip Kittur; Fiscal Year: 2005
    ..They will also uncover the mechanisms of action of Ginger and Milk thistle, determine if these herbal products interact with conventional immunosuppressive drugs, and potentially discover novel immunomodulatory agents. ..
  42. Angiocidal Effect of Cyclosporine in Cancer Therapy
    Dilip Kittur; Fiscal Year: 2006
    ..Our studies have the potential of discovering a novel, angiocidal effect of a commonly used drug. If successful, these studies will be translated expeditiously into clinical trials for the treatment of cancer. ..
  43. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
    ..The WNT2 findings will be further examined in two-independent patient samples. ..
  44. TRANSPOSON ACTIVE TRANSGENIC XIPHOPHORUS
    RONALD WALTER; Fiscal Year: 2003
    ..abstract_text> ..
  45. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  46. High Throughput Assays for Ion Channel Activities of Influenza A & B Viruses
    LAWRENCE PINTO; Fiscal Year: 2006
    ..These assays will make it possible to perform efficient searches for antiviral drugs against the M2 ion channels. [unreadable] [unreadable] [unreadable] [unreadable]..
  47. RESPIRATORY VIRUS ION CHANNELS
    LAWRENCE PINTO; Fiscal Year: 2007
    ..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]..
  48. Molecular basis of reproductive isolation in Drosophila
    AMANDA MOEHRING; Fiscal Year: 2007
    ..simulans and its sibling species D. mauritiana and D. sechellia. Information from studies of Drosophila fertility can then potentially be applied to understanding the genetics of human fertility. ..
  49. Advances in Mineral Metabolism (AIMM) annual meeting
    Rene St Arnaud; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..