Summary: The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.

Top Publications

  1. ncbi The molecular genetics of crop domestication
    John F Doebley
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Cell 127:1309-21. 2006
  2. pmc Prediction of total genetic value using genome-wide dense marker maps
    T H Meuwissen
    Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
    Genetics 157:1819-29. 2001
  3. ncbi Invited review: Genomic selection in dairy cattle: progress and challenges
    B J Hayes
    Department of Primary Industries Victoria, Biosciences Research Division, Bundoora, Australia
    J Dairy Sci 92:433-43. 2009
  4. pmc Whole-genome regression and prediction methods applied to plant and animal breeding
    Gustavo de Los Campos
    Department of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Genetics 193:327-45. 2013
  5. ncbi Genome-wide genetic changes during modern breeding of maize
    Yinping Jiao
    State Key Laboratory of Agrobiotechnology and National Maize Improvement Center, China Agricultural University, Beijing, People s Republic of China
    Nat Genet 44:812-5. 2012
  6. ncbi Breeding technologies to increase crop production in a changing world
    Mark Tester
    Australian Centre for Plant Functional Genomics, University of Adelaide, South Australia SA 5064, Australia
    Science 327:818-22. 2010
  7. pmc The impact of genetic relationship information on genome-assisted breeding values
    D Habier
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Genetics 177:2389-97. 2007
  8. pmc Development and evaluation of a 9K SNP array for peach by internationally coordinated SNP detection and validation in breeding germplasm
    Ignazio Verde
    CRA Fruit Tree Research Center, Rome, Italy
    PLoS ONE 7:e35668. 2012
  9. ncbi Next-generation sequencing technologies and their implications for crop genetics and breeding
    Rajeev K Varshney
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru 502324, A P, India
    Trends Biotechnol 27:522-30. 2009
  10. pmc Analysis of copy number variations among diverse cattle breeds
    George E Liu
    USDA ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland 20705, USA
    Genome Res 20:693-703. 2010

Detail Information

Publications351 found, 100 shown here

  1. ncbi The molecular genetics of crop domestication
    John F Doebley
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Cell 127:1309-21. 2006
  2. pmc Prediction of total genetic value using genome-wide dense marker maps
    T H Meuwissen
    Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
    Genetics 157:1819-29. 2001
    ..It was concluded that selection on genetic values predicted from markers could substantially increase the rate of genetic gain in animals and plants, especially if combined with reproductive techniques to shorten the generation interval...
  3. ncbi Invited review: Genomic selection in dairy cattle: progress and challenges
    B J Hayes
    Department of Primary Industries Victoria, Biosciences Research Division, Bundoora, Australia
    J Dairy Sci 92:433-43. 2009
    A new technology called genomic selection is revolutionizing dairy cattle breeding. Genomic selection refers to selection decisions based on genomic breeding values (GEBV)...
  4. pmc Whole-genome regression and prediction methods applied to plant and animal breeding
    Gustavo de Los Campos
    Department of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Genetics 193:327-45. 2013
    Genomic-enabled prediction is becoming increasingly important in animal and plant breeding and is also receiving attention in human genetics...
  5. ncbi Genome-wide genetic changes during modern breeding of maize
    Yinping Jiao
    State Key Laboratory of Agrobiotechnology and National Maize Improvement Center, China Agricultural University, Beijing, People s Republic of China
    Nat Genet 44:812-5. 2012
    The success of modern maize breeding has been demonstrated by remarkable increases in productivity over the last four decades. However, the underlying genetic changes correlated with these gains remain largely unknown...
  6. ncbi Breeding technologies to increase crop production in a changing world
    Mark Tester
    Australian Centre for Plant Functional Genomics, University of Adelaide, South Australia SA 5064, Australia
    Science 327:818-22. 2010
    ..Hence, new technologies must be developed to accelerate breeding through improving genotyping and phenotyping methods and by increasing the available genetic diversity in ..
  7. pmc The impact of genetic relationship information on genome-assisted breeding values
    D Habier
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Genetics 177:2389-97. 2007
    The success of genomic selection depends on the potential to predict genome-assisted breeding values (GEBVs) with high accuracy over several generations without additional phenotyping after estimating marker effects...
  8. pmc Development and evaluation of a 9K SNP array for peach by internationally coordinated SNP detection and validation in breeding germplasm
    Ignazio Verde
    CRA Fruit Tree Research Center, Rome, Italy
    PLoS ONE 7:e35668. 2012
    ..number of single nucleotide polymorphism (SNP) markers covering the entire genome are needed to enable molecular breeding efforts such as genome wide association studies, fine mapping, genomic selection and marker-assisted selection in ..
  9. ncbi Next-generation sequencing technologies and their implications for crop genetics and breeding
    Rajeev K Varshney
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru 502324, A P, India
    Trends Biotechnol 27:522-30. 2009
    ..introgression, epigenetic modifications, transcript profiling, population genetics and de novo genome/organellar genome assembly for which these technologies are expected to advance crop genetics and breeding, leading to crop improvement.
  10. pmc Analysis of copy number variations among diverse cattle breeds
    George E Liu
    USDA ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland 20705, USA
    Genome Res 20:693-703. 2010
    ..Our results provide a valuable resource beyond microsatellites and single nucleotide polymorphisms to explore the full dimension of genetic variability for future cattle genomic research...
  11. ncbi Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panels
    M Erbe
    Department of Animal Sciences, Animal Breeding and Genetics Group, Georg August University Gottingen, 37075 Gottingen, Germany
    J Dairy Sci 95:4114-29. 2012
    Achieving accurate genomic estimated breeding values for dairy cattle requires a very large reference population of genotyped and phenotyped individuals...
  12. ncbi Efficient mapping of mendelian traits in dogs through genome-wide association
    Elinor K Karlsson
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1321-8. 2007
  13. pmc Deregressing estimated breeding values and weighting information for genomic regression analyses
    Dorian J Garrick
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 41:55. 2009
    Genomic prediction of breeding values involves a so-called training analysis that predicts the influence of small genomic regions by regression of observed information on marker genotypes for a given population of individuals...
  14. pmc Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traits
    Ben J Hayes
    Biosciences Research Division, Department of Primary Industries Victoria, Melbourne, Victoria, Australia
    PLoS Genet 6:e1001139. 2010
    Prediction of genetic merit using dense SNP genotypes can be used for estimation of breeding values for selection of livestock, crops, and forage species; for prediction of disease risk; and for forensics...
  15. pmc Prediction of genetic values of quantitative traits in plant breeding using pedigree and molecular markers
    Jose Crossa
    School of Land Crop and Food Sciences, University of Queensland, 4072, Sta Lucia, Queensland, Australia
    Genetics 186:713-24. 2010
    The availability of dense molecular markers has made possible the use of genomic selection (GS) for plant breeding. However, the evaluation of models for GS in real plant populations is very limited...
  16. ncbi Mapping genes for complex traits in domestic animals and their use in breeding programmes
    Michael E Goddard
    Department of Agriculture and Food Systems, University of Melbourne, Royal Parade, Parkville 3010, Australia
    Nat Rev Genet 10:381-91. 2009
    ..This approach is expected to double the rate of genetic improvement per year in many livestock systems...
  17. ncbi Genomic selection: prediction of accuracy and maximisation of long term response
    Mike Goddard
    Department of Primary Industries, University of Melbourne, Victoria, Australia
    Genetica 136:245-57. 2009
    Genomic selection refers to the use of dense markers covering the whole genome to estimate the breeding value of selection candidates for a quantitative trait...
  18. pmc A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies
    Molly E McCue
    College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA
    PLoS Genet 8:e1002451. 2012
    ..These results demonstrate the high quality of this SNP genotyping resource, its usefulness in diverse genome analyses of the horse, and potential use in related species...
  19. ncbi Genomic selection in plant breeding: from theory to practice
    Jean Luc Jannink
    USDA ARS, R W Holley Center for Agriculture and Health, Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
    Brief Funct Genomics 9:166-77. 2010
    ..Selection can be based on GS predictions, potentially leading to more rapid and lower cost gains from breeding. The objectives of this article are to review essential aspects of GS and summarize the important take-home ..
  20. pmc A single IGF1 allele is a major determinant of small size in dogs
    Nathan B Sutter
    National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
    Science 316:112-5. 2007
    ..A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs...
  21. pmc Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA
    Andreia J Amaral
    Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 6:e14782. 2011
    ..Artificial selection has caused rapid evolution in domesticated species. The identification of selection footprints across domesticated genomes can contribute to uncover the genetic basis of phenotypic diversity...
  22. pmc Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping
    Amaury Vaysse
    Institut de Génétique et Développement de Rennes, CNRS UMR6061, Universite de Rennes 1, Rennes, France
    PLoS Genet 7:e1002316. 2011
    ..Further elucidation of the variants under selection will help to uncover the genetic basis of complex traits and disease...
  23. pmc Genome-wide SNP detection, validation, and development of an 8K SNP array for apple
    David Chagne
    Plant and Food Research, Palmerston North Research Centre, Palmerston North, New Zealand
    PLoS ONE 7:e31745. 2012
    As high-throughput genetic marker screening systems are essential for a range of genetics studies and plant breeding applications, the International RosBREED SNP Consortium (IRSC) has utilized the Illumina Infinium® II system to develop ..
  24. pmc Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
    Bridgett M VonHoldt
    Department of Ecology and Evolutionary Biology, 621 Charles E Young Drive South, University of California, Los Angeles, California 90095, USA
    Nature 464:898-902. 2010
    ..More recently, the evolution of modern dog breeds seems to have been an iterative process that drew on a limited genetic toolkit to create remarkable phenotypic diversity...
  25. ncbi Imputation of genotypes with low-density chips and its effect on reliability of direct genomic values in Dutch Holstein cattle
    H A Mulder
    Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, PO Box 65, 8200 AB Lelystad, The Netherlands
    J Dairy Sci 95:876-89. 2012
    ..selection using 50,000 single nucleotide polymorphism (50k SNP) chips has been implemented in many dairy cattle breeding programs. Cheap, low-density chips make genotyping of a larger number of animals cost effective...
  26. pmc The importance of information on relatives for the prediction of genomic breeding values and the implications for the makeup of reference data sets in livestock breeding schemes
    Samuel A Clark
    University of New England, Armidale, NSW 2351, Australia
    Genet Sel Evol 44:4. 2012
    ..This study aimed to examine the importance of information on relatives versus that of unrelated or more distantly related individuals on the estimation of genomic breeding values.
  27. pmc High-density SNP genotyping of tomato (Solanum lycopersicum L.) reveals patterns of genetic variation due to breeding
    Sung Chur Sim
    Department of Horticulture and Crop Science, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH, USA
    PLoS ONE 7:e45520. 2012
    ..LD decay varied between chromosomes and sub-populations, with large differences reflective of breeding history. For example, on chromosome 11, decay occurred over 0.8 cM for processing accessions and over 19...
  28. pmc Different models of genetic variation and their effect on genomic evaluation
    Samuel A Clark
    School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
    Genet Sel Evol 43:18. 2011
    ..Therefore, a better understanding of what genomic selection actually predicts is relevant so that appropriate methods of analysis are used in genomic evaluations...
  29. ncbi Footprints of selection in the ancestral admixture of a New World Creole cattle breed
    Mathieu Gautier
    INRA, UMR CBGP INRA CIRAD IRD Supagro, Montferrier sur Lez, France
    Mol Ecol 20:3128-43. 2011
    ..This study illustrates the relevance of admixed populations to identify footprints of selection by combining several tests straightforward to implement on large data sets...
  30. pmc Application of site and haplotype-frequency based approaches for detecting selection signatures in cattle
    Saber Qanbari
    Animal Breeding and Genetics Group, Department of Animal Sciences, Georg August University, 37075 Gottingen, Germany
    BMC Genomics 12:318. 2011
  31. pmc Design of a bovine low-density SNP array optimized for imputation
    Didier Boichard
    UMR1313 Animal Genetics and Integrative Biology, National Institute for Agricultural Research INRA, Jouy en Josas, France
    PLoS ONE 7:e34130. 2012
    ..The minor allele frequencies were similar across taurine beef and dairy breeds as was the proportion of SNPs that were polymorphic. The new BovineLD chip should facilitate low-cost genomic selection in taurine beef and dairy cattle...
  32. ncbi Genomic selection
    M E Goddard
    University of Melbourne, Attwood, Australia
    J Anim Breed Genet 124:323-30. 2007
    ..Simulation results and limited experimental results suggest that breeding values can be predicted with high accuracy using genetic markers alone but more validation is required especially ..
  33. pmc Accuracies of genomic breeding values in American Angus beef cattle using K-means clustering for cross-validation
    Mahdi Saatchi
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 43:40. 2011
    Genomic selection is a recently developed technology that is beginning to revolutionize animal breeding. The objective of this study was to estimate marker effects to derive prediction equations for direct genomic values for 16 routinely ..
  34. ncbi Effect of imputing markers from a low-density chip on the reliability of genomic breeding values in Holstein populations
    R Dassonneville
    INRA, UMR1313 Génétique Animale et Biologie Intégrative GABI, 78350 Jouy en Josas, France
    J Dairy Sci 94:3679-86. 2011
    ..investigate the imputation error and loss of reliability of direct genomic values (DGV) or genomically enhanced breeding values (GEBV) when using genotypes imputed from a 3,000-marker single nucleotide polymorphism (SNP) panel to a 50,..
  35. ncbi Accuracy of prediction of genomic breeding values for residual feed intake and carcass and meat quality traits in Bos taurus, Bos indicus, and composite beef cattle
    S Bolormaa
    Victorian Department of Primary Industries, Bundoora, VIC 3083, Australia
    J Anim Sci 91:3088-104. 2013
    ..All traits appear to be highly polygenic with thousands of SNP independently associated with each trait. ..
  36. ncbi Mapping QTL for agronomic traits in breeding populations
    Tobias Würschum
    State Plant Breeding Institute, University of Hohenheim, 70593 Stuttgart, Germany
    Theor Appl Genet 125:201-10. 2012
    Detection of quantitative trait loci (QTL) in breeding populations offers the advantage that these QTL are of direct relevance for the improvement of crops via knowledge-based breeding...
  37. ncbi Bridging the genotyping gap: using genotyping by sequencing (GBS) to add high-density SNP markers and new value to traditional bi-parental mapping and breeding populations
    Jennifer Spindel
    Department of Plant Breeding and Genetics, Cornell University, 162 Emerson Hall, Ithaca, NY, 14853 1901, USA
    Theor Appl Genet 126:2699-716. 2013
    ..general interest "reference" genomes, the low cost of GBS makes it an attractive means of saturating mapping and breeding populations with a high density of SNP markers...
  38. pmc Linking deforestation to malaria in the Amazon: characterization of the breeding habitat of the principal malaria vector, Anopheles darlingi
    Amy Y Vittor
    Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Trop Med Hyg 81:5-12. 2009
    This study examined the larval breeding habitat of a major South American malaria vector, Anopheles darlingi, in areas with varying degrees of ecologic alteration in the Peruvian Amazon...
  39. ncbi Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score
    I Aguilar
    Animal and Dairy Science Department, University of Georgia, Athens 30602 Instituto Nacional de Investigación Agropecuaria, Las Brujas 90200, Uruguay
    J Dairy Sci 93:743-52. 2010
    ..Advantages of single-step evaluations should increase in the future when animals are pre-selected on genotypes...
  40. pmc The accuracy of Genomic Selection in Norwegian red cattle assessed by cross-validation
    Tu Luan
    Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Box 5003, N 1432 As, Norway
    Genetics 183:1119-26. 2009
    Genomic Selection (GS) is a newly developed tool for the estimation of breeding values for quantitative traits through the use of dense markers covering the whole genome...
  41. ncbi Genomic prediction of simulated multibreed and purebred performance using observed fifty thousand single nucleotide polymorphism genotypes
    K Kizilkaya
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    J Anim Sci 88:544-51. 2010
    ..Improved across breed prediction of genomic merit will require panels with more than 50,000 markers...
  42. ncbi Genetic effects of captive breeding cause a rapid, cumulative fitness decline in the wild
    Hitoshi Araki
    Department of Zoology, 3029 Cordley Hall, Oregon State University Corvallis, OR 97331, USA
    Science 318:100-3. 2007
    Captive breeding is used to supplement populations of many species that are declining in the wild. The suitability of and long-term species survival from such programs remain largely untested, however...
  43. ncbi Distribution and location of genetic effects for dairy traits
    J B Cole
    Animal Improvement Programs Laboratory, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 92:2931-46. 2009
    ..Additive genetic merits were constructed for each chromosome, and the distribution of BTA14-specific estimated breeding value (EBV) showed that selection primarily for milk yield has not changed the distribution of EBV for fat ..
  44. pmc A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken
    Ben Dorshorst
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002412. 2011
    ..This complex genomic rearrangement causing a specific monogenic trait in the chicken illustrates how novel mutations with major phenotypic effects have been reused during breed formation in domestic animals...
  45. ncbi Prediction of unobserved single nucleotide polymorphism genotypes of Jersey cattle using reference panels and population-based imputation algorithms
    K A Weigel
    Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Dairy Sci 93:2229-38. 2010
    ..SNP) genotypes for dairy cattle has created exciting research opportunities and revolutionized practical breeding programs...
  46. pmc Identification of selection signatures in cattle breeds selected for dairy production
    Alessandra Stella
    Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, 20133 Milan, Italy
    Genetics 185:1451-61. 2010
  47. ncbi Technical note: an R package for fitting generalized linear mixed models in animal breeding
    A I Vazquez
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Anim Sci 88:497-504. 2010
    ..Estimation methods available in pedigreemm include approximations to maximum likelihood and REML. This note describes the classes of models that can be fitted using pedigreemm and presents examples that illustrate its use...
  48. pmc Identifying loci influencing 1,000-kernel weight in wheat by microsatellite screening for evidence of selection during breeding
    Lanfen Wang
    Key Laboratory of Crop Germplasm Resources and Utilization, Ministry of Agriculture, The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China
    PLoS ONE 7:e29432. 2012
    ..84% of the total phenotypic variation. Favored alleles for breeding at the 22 loci were inferred according to their estimated effects on MTKW based on mean difference of varieties ..
  49. pmc Population structure and genetic differentiation associated with breeding history and selection in tomato (Solanum lycopersicum L.)
    S C Sim
    Department of Horticulture and Crop Science, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA
    Heredity (Edinb) 106:927-35. 2011
    ..These subpopulations correspond to historical patterns of breeding conducted for specific production environments...
  50. ncbi Prediction of response to marker-assisted and genomic selection using selection index theory
    J C M Dekkers
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011 3150, USA
    J Anim Breed Genet 124:331-41. 2007
    ..By specifying estimates of breeding values derived from marker information (M-EBV) as a correlated trait with heritability equal to 1, it was ..
  51. pmc The impact of genetic relationship information on genomic breeding values in German Holstein cattle
    David Habier
    Institute of Animal Breeding and Husbandry, Christian Albrechts University of Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Genet Sel Evol 42:5. 2010
    ..of additive-genetic relationships captured by single nucleotide polymorphisms (SNPs) on the accuracy of genomic breeding values (GEBVs) has been demonstrated, but recent studies on data obtained from Holstein populations have ignored ..
  52. pmc A common reference population from four European Holstein populations increases reliability of genomic predictions
    Mogens S Lund
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, AU Foulum, PO Box 50, DK 8830 Tjele, Denmark
    Genet Sel Evol 43:43. 2011
    ..Increased accuracies of genomic predictions depend on the number of individuals added to the reference population, the reliability of their phenotypes, and the relatedness of the populations that are combined...
  53. pmc Identifying the most productive breeding sites for malaria mosquitoes in The Gambia
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 8:62. 2009
    ..Despite the plethora of potential mosquito breeding sites found in the floodplains of the Gambia River, about 150 km from its mouth, during the rainy season, only a ..
  54. pmc A genome wide survey of SNP variation reveals the genetic structure of sheep breeds
    James W Kijas
    CSIRO Livestock Industries, St Lucia, Brisbane, Queensland, Australia
    PLoS ONE 4:e4668. 2009
    ..Furthermore, the identification of a subset of SNP able to assign individuals into broad groupings demonstrates even a small panel of markers may be suitable for applications such as traceability...
  55. ncbi A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes
    J E Pryce
    Biosciences Research Division, Department of Primary Industries Victoria, Bundoora 3083, Australia
    J Dairy Sci 93:3331-45. 2010
    ..Promising candidate genes have been identified in several of the validated regions...
  56. pmc Genomic prediction when some animals are not genotyped
    Ole F Christensen
    Aarhus University, Faculty of Agricultural Sciences, Dept of Genetics and Biotechnology, Blichers alle 20, PO Box 50, DK 8830 Tjele, Denmark
    Genet Sel Evol 42:2. 2010
    The use of genomic selection in breeding programs may increase the rate of genetic improvement, reduce the generation time, and provide higher accuracy of estimated breeding values (EBVs)...
  57. ncbi Genome-wide genetic association of complex traits in heterogeneous stock mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 38:879-87. 2006
    ..Our data set, freely available at, provides an entry point to the functional characterization of genes involved in many complex traits...
  58. ncbi Anopheles gambiae s.s. breeding in polluted water bodies in urban Lagos, southwestern Nigeria
    T S Awolola
    Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
    J Vector Borne Dis 44:241-4. 2007
    Urban malaria is on the rise in Nigeria due to rapid industrialisation and developmental activities. A study was undertaken in Lagos, Nigeria to study the Anopheles breeding in polluted water bodies.
  59. ncbi Population genetics of genomics-based crop improvement methods
    Martha T Hamblin
    Institute for Genomic Diversity, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 27:98-106. 2011
  60. ncbi Accuracy of genomic selection in European maize elite breeding populations
    Yusheng Zhao
    State Plant Breeding Institute, University of Hohenheim, 70599, Stuttgart, Germany
    Theor Appl Genet 124:769-76. 2012
    Genomic selection is a promising breeding strategy for rapid improvement of complex traits. The objective of our study was to investigate the prediction accuracy of genomic breeding values through cross validation...
  61. pmc Deregressed EBV as the response variable yield more reliable genomic predictions than traditional EBV in pure-bred pigs
    Tage Ostersen
    The Danish Agricultural and Food Council, Pig Research Centre, Breeding and Genetics, Axeltorv 3, DK 1609, Denmark
    Genet Sel Evol 43:38. 2011
    ..For pure-bred pigs, it was hypothesised that deregressed estimated breeding values (EBV) with the parent average removed as the response variable generate higher reliabilities of genomic ..
  62. pmc Allele coding in genomic evaluation
    Ismo Strandén
    Biotechnology and Food Research, MTT Agrifood Research Finland, FI 31600 Jokioinen, Finland
    Genet Sel Evol 43:25. 2011
    Genomic data are used in animal breeding to assist genetic evaluation. Several models to estimate genomic breeding values have been studied. In general, two approaches have been used...
  63. pmc Will genomic selection be a practical method for plant breeding?
    Akihiro Nakaya
    Center for Transdisciplinary Research, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8585, Japan
    Ann Bot 110:1303-16. 2012
    ..GS is a form of MAS that selects favourable individuals based on genomic estimated breeding values...
  64. ncbi Genomic inbreeding and relationships among Holsteins, Jerseys, and Brown Swiss
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 94:5673-82. 2011
    ..Pedigree relationship matrices ignore common ancestry shared by base animals within breed and may not approximate genomic relationships well in multibreed populations...
  65. pmc Genome wide signatures of positive selection: the comparison of independent samples and the identification of regions associated to traits
    William Barendse
    Commonwealth Scientific and Industrial Research Organization, Queensland Bioscience Precinct, St Lucia, Queensland, Australia
    BMC Genomics 10:178. 2009
    ..The goal of genome wide analyses of polymorphisms is to achieve a better understanding of the link between genotype and phenotype. Part of that goal is to understand the selective forces that have operated on a population...
  66. ncbi Association mapping of iron deficiency chlorosis loci in soybean (Glycine max L. Merr.) advanced breeding lines
    Ju Wang
    Department of Plant Sciences, North Dakota State University, Fargo, ND 58105 5051, USA
    Theor Appl Genet 116:777-87. 2008
    ..Two independent soybean populations consisting of advanced breeding lines representing the diversity within maturity groups 00, 0, and I were screened in multi-site, replicated ..
  67. pmc Comparative analyses of genetic trends and prospects for selection against hip and elbow dysplasia in 15 UK dog breeds
    Thomas W Lewis
    Kennel Club Genetics Centre at the Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    BMC Genet 14:16. 2013
    ..Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection against hip and elbow dysplasia (another ..
  68. pmc Incorporation of competitive effects in forest tree or animal breeding programs
    William M Muir
    Department of Animal Science, Purdue University, West Lafayette, Indiana 47907 1151, USA
    Genetics 170:1247-59. 2005
    ..usual quantitative genetic model ignores these competitive interactions and could result in seriously incorrect breeding decisions and acerbate animal well-being...
  69. pmc SNP discovery and linkage map construction in cultivated tomato
    Kenta Shirasawa
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 17:381-91. 2010
    ..then screened against cultivated tomato lines in order to estimate the transferability of these SNPs to other breeding materials...
  70. pmc Genome-wide association scan and phased haplotype construction for quantitative trait loci affecting boar taint in three pig breeds
    Vivi R Gregersen
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, P, O, Box 50, DK 8830 Tjele, Denmark
    BMC Genomics 13:22. 2012
    ..In the study presented in this paper, markers and haplotypes, which can be applied to DNA-based selection schemes in order to reduce or eliminate the boar taint problem, are identified...
  71. pmc Four loci explain 83% of size variation in the horse
    Shokouh Makvandi-Nejad
    Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e39929. 2012
    ..Our results in the horse, complemented by the prior work in cattle and dog, serve to pinpoint those very few genes that have played major roles in the rapid evolution of size during domestication...
  72. ncbi Breeding for high water-use efficiency
    A G Condon
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    J Exp Bot 55:2447-60. 2004
    There is a pressing need to improve the water-use efficiency of rain-fed and irrigated crop production. Breeding crop varieties with higher water-use efficiency is seen as providing part of the solution...
  73. pmc Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids
    Eli Grindflek
    NORSVIN The Norwegian Pig Breeders Association, 2304 Hamar, Norway
    BMC Genomics 12:362. 2011
    ..This represents a challenge when performing selection against androstenone in breeding programs, without simultaneously decreasing levels of other steroids...
  74. ncbi Genome-wide association study for calving traits in Danish and Swedish Holstein cattle
    G Sahana
    Aarhus University, Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Research Centre Foulum, DK 8830, Tjele, Denmark
    J Dairy Sci 94:479-86. 2011
    ..The identification of calving trait-associated single nucleotide polymorphisms and mapping of the corresponding QTL in small chromosomal regions will facilitate the search for candidate calving performance genes and polymorphisms...
  75. ncbi Experimental evidence for density-dependent reproduction in a cooperatively breeding passerine
    Lyanne Brouwer
    Evolutionary Ecology Group, School of Botany and Zoology, Australian National University, Canberra, ACT 0200 Australia
    Ecology 90:729-41. 2009
    ..Islands with the highest insect densities also had the highest bird densities and the largest breeding groups...
  76. pmc Factors affecting accuracy from genomic selection in populations derived from multiple inbred lines: a Barley case study
    Shengqiang Zhong
    Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA
    Genetics 182:355-64. 2009
    ..True breeding values (TBV) were simulated on the basis of 20 or 80 additive QTL...
  77. pmc Linkage disequilibrium decay and haplotype block structure in the pig
    Andreia J Amaral
    Animal Breeding and Genomics Centre, Wageningen UR, 6700AH, Wageningen, The Netherlands
    Genetics 179:569-79. 2008
    ..First, the European ancestral stock had a higher level of LD. Second, modern breeding programs increased the extent of LD in Europe and caused differences of LD between genomic regions...
  78. pmc Accuracy of genomic breeding values in multi-breed dairy cattle populations
    Ben J Hayes
    Biosciences Research Division, Department of Primary Industries Victoria, Bundoora, Australia
    Genet Sel Evol 41:51. 2009
    ..are 1) the reference population used must be very large to subsequently predict accurate genomic estimated breeding values (GEBV), and 2) prediction equations derived in one breed do not predict accurate GEBV when applied to ..
  79. pmc Highly focused anopheline breeding sites and malaria transmission in Dakar
    Vanessa Machault
    Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
    Malar J 8:138. 2009
    ..heterogeneity of malaria transmission was investigated in Dakar, in order to characterize the Anopheles breeding sites in the city and to study the dynamics of larval density and adult aggressiveness in ten characteristically ..
  80. pmc Integrated genomics, physiology and breeding approaches for improving drought tolerance in crops
    Reyazul Rouf Mir
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, Hyderabad 502 324, India
    Theor Appl Genet 125:625-45. 2012
    ..Modern genomics and genetic approaches coupled with advances in precise phenotyping and breeding methodologies are expected to more effectively unravel the genes and metabolic pathways that confer drought ..
  81. ncbi Breeding for water-saving and drought-resistance rice (WDR) in China
    L J Luo
    Shanghai Agrobiological Gene Center, 2901 Beidi Road, Shanghai 201106, China
    J Exp Bot 61:3509-17. 2010
    ..The breeding target is a high yield potential under irrigation, an acceptable grain quality, and water consumption reduced by ..
  82. ncbi Metabolomics-assisted breeding: a viable option for crop improvement?
    Alisdair R Fernie
    Max Planck Institute für Molekulare Pfanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Trends Genet 25:39-48. 2009
    ..Metabolomics represents an important addition to the tools currently employed in genomics-assisted selection for crop improvement...
  83. pmc The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
    Elissa J Chesler
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
    Mamm Genome 19:382-9. 2008 investigate biomolecular networks and systems-level phenotypes underlying complex traits, we have initiated breeding of a new genetic reference population of mice, the Collaborative Cross...
  84. pmc DArT markers for the rye genome - genetic diversity and mapping
    Hanna Bolibok-Bragoszewska
    Department of Plant Genetics, Breeding and Biotechnology, Warsaw University of Life Sciences SGGW, 02 776 Warsaw, Poland
    BMC Genomics 10:578. 2009
    Implementation of molecular breeding in rye (Secale cereale L.) improvement programs depends on the availability of high-density molecular linkage maps...
  85. ncbi Precocious flowering in trees: the FLOWERING LOCUS T gene as a research and breeding tool in Populus
    Huanling Zhang
    Northwest A and F University, College of Forestry, Yangling, 712100 People s Republic of China
    J Exp Bot 61:2549-60. 2010
    ..of FT should be of particular use in forest trees, as it could greatly accelerate and enable new kinds of breeding and research...
  86. ncbi Genome-wide association and genomic selection in animal breeding
    Ben Hayes
    Biosciences Research Division, Department of Primary Industries Victoria, 1 Park Drive, Bundoora 3083, Australia
    Genome 53:876-83. 2010
    ..The genomic breeding values are predicted to be the sum of the effect of these SNPs across the entire genome...
  87. ncbi Feasibility and implications of breeding sheep for resilience to nematode challenge
    S A Bisset
    AgResearch Wallaceville, Upper Hutt, New Zealand
    Int J Parasitol 26:857-68. 1996
    ..Our results suggest that the main benefits of selectively breeding for low FEC are likely to be derived indirectly as a result of reduced pasture contamination...
  88. ncbi More genomic resources for less-studied crops
    Rajeev K Varshney
    International Crops Research Institute for the Semi Arid Tropics, Patancheru 502324, A P, India
    Trends Biotechnol 28:452-60. 2010
    ..These resources have the potential to accelerate gene discovery and initiate molecular breeding in these crops, thereby enhancing crop productivity to ensure food security in developing countries.
  89. ncbi Identification and characterization of large-effect quantitative trait loci for grain yield under lowland drought stress in rice using bulk-segregant analysis
    Ramaiah Venuprasad
    Plant Breeding Genetics and Biotechnology Division, International Rice Research Institute, DAPO Box 7777, Manila, Philippines
    Theor Appl Genet 120:177-90. 2009
    ..The Apo alleles for these large-effect QTL for grain yield under drought and aerobic conditions may be immediately exploited in marker-assisted-breeding to improve the drought tolerance of Swarna.
  90. pmc Reliability of genomic predictions across multiple populations
    A P W de Roos
    Biosciences Research Division, Department of Primary Industries Victoria, University of Melbourne, Bundoora 3083, Australia
    Genetics 183:1545-53. 2009
    ..Our results suggest that the most accurate genomic predictions are achieved when phenotypes from all populations are combined in one training set, while for more diverged populations a higher marker density is required...
  91. pmc Complete chloroplast genome of Oncidium Gower Ramsey and evaluation of molecular markers for identification and breeding in Oncidiinae
    Fu Hui Wu
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
    BMC Plant Biol 10:68. 2010
    ..However, they are amenable to intergeneric and inter-specific crossing making phylogenetic identification very difficult. Molecular markers derived from the chloroplast genome can provide useful tools for phylogenetic resolution...
  92. ncbi Flowering time control and applications in plant breeding
    Christian Jung
    Plant Breeding Institute, Christian Albrechts University of Kiel, D 24098 Kiel, Germany
    Trends Plant Sci 14:563-73. 2009
    Shifting the seasonal timing of reproduction is a major goal of plant breeding efforts to produce novel varieties that are better adapted to local environments and changing climatic conditions...
  93. pmc Population structure and genetic diversity in a commercial maize breeding program assessed with SSR and SNP markers
    Delphine Van Inghelandt
    Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70593, Stuttgart, Germany
    Theor Appl Genet 120:1289-99. 2010
    Information about the genetic diversity and population structure in elite breeding material is of fundamental importance for the improvement of crops...
  94. ncbi Shifts in caterpillar biomass phenology due to climate change and its impact on the breeding biology of an insectivorous bird
    Marcel E Visser
    Netherlands Institute of Ecology NIOO KNAW, P O Box 40, 6666 ZG, Heteren, The Netherlands
    Oecologia 147:164-72. 2006
    ..The birds will start breeding earlier and this advancement is predicted to be at the same rate as the advancement of the food peak, and hence ..
  95. pmc High-resolution haplotype block structure in the cattle genome
    Rafael Villa-Angulo
    Department of Bioinformatics and Computational Biology, George Mason University, VA, USA
    BMC Genet 10:19. 2009
    ..6 Mb with an average density of approximately one SNP per 4 kb, and characterized the linkage disequilibrium (LD) and haplotype block structure within individual breeds and groups of breeds in relation to their geographic origin and use...
  96. ncbi Genetic diversity within and between European pig breeds using microsatellite markers
    M SanCristobal
    Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique, 31326 Castanet Tolosan Cedex, France
    Anim Genet 37:189-98. 2006
    ..This study has consequences for the interpretation of biodiversity results and will be of importance for future conservation programmes...
  97. ncbi Accuracy of genotypic value predictions for marker-based selection in biparental plant populations
    Robenzon E Lorenzana
    Department of Agronomy and Plant Genetics, University of Minnesota, 411 Borlaug Hall, 1991 Upper Buford Circle, Saint Paul, MN 55108, USA
    Theor Appl Genet 120:151-61. 2009
    The availability of cheap and abundant molecular markers has led to plant-breeding methods that rely on the prediction of genotypic value from marker data, but published information is lacking on the accuracy of genotypic value ..
  98. pmc Biodiversity of pig breeds from China and Europe estimated from pooled DNA samples: differences in microsatellite variation between two areas of domestication
    Hendrik Jan Megens
    Wageningen University, Animal Breeding and Genomics Centre, PO Box 338, 6700AH, Wageningen, The Netherlands
    Genet Sel Evol 40:103-28. 2008
    ..A likely cause is a more diverse wild boar population in Asia, but various other possible contributing factors are discussed...
  99. pmc Short interspersed elements (SINEs) are a major source of canine genomic diversity
    Wei Wang
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Genome Res 15:1798-808. 2005
  100. pmc Anopheles culicifacies breeding in brackish waters in Sri Lanka and implications for malaria control
    Pavilupillai J Jude
    Department of Zoology, Faculty of Science, University of Jaffna, Jaffna, Sri Lanka
    Malar J 9:106. 2010
    ..subpictus exists as a complex of species A-D. The freshwater breeding habit of An. culicifacies is well established...
  101. pmc Breeding value prediction for production traits in layer chickens using pedigree or genomic relationships in a reduced animal model
    Anna Wolc
    Department of Genetics and Animal Breeding, University of Life Sciences in Poznan, Wołyńska st, 33, 60 637 Poznan, Poland
    Genet Sel Evol 43:5. 2011
    Genomic selection involves breeding value estimation of selection candidates based on high-density SNP genotypes...

Research Grants72

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..These animals are currently breeding with wildtype mice to establish germ-line transmission of the targeted allele...
  2. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..analysis, sequence data and functional genomics, high throughput DNA sequencing, the use of short term selective breeding to confirm the role of Drd2 network coherence in haloperidol response and the integration of the QTL and network ..
  3. Tobacco Control Research Branch Scientific and Technical Services Support
    KOURTNEY MARSHALL; Fiscal Year: 2009
    ..relate to the "targeting" of special populations; 9) Tobacco growing practices, particularly those dealing with breeding and genetics which change the tobacco and tobacco smoke constituents; 10) The epidemiologic, clinical or ..
  4. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..because all the required tools can be brought together by breeding. This technology will make it possible to stimulate, for example, a specific population of neurons with channel ..
    Paul R Odgren; Fiscal Year: 2012
    ..We are maintaining an ongoing out-crossed breeding project to narrow the candidate region and are sequencing genes in the chromosome interval containing the ..
  6. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..genetic engineering, which is difficult to do with more than one regulator simultaneously and also requires breeding for generations and is thus slow, or by mechanically connecting the mouse to a pump via an external tether, which ..
  7. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..generated mice lacking the TRPC4, TRPC5, both TRPC4 and TRPC5 genes, obtained the TRPC1 knockout mouse, and are breeding TRPC1/4/5 triple knockout mice...
  8. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..Herein, we will determine whether BPA can exert transgenerational effects by breeding black (a/a) females to viable yellow (Avy/a) males...
  9. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..Mice which lack the Rhox5 gene exhibit abnormalities in sperm number, sperm motility, and breeding efficiency...
  10. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Finally, we will establish breeding herds to generate LDLR-/- pigs and to expand and propagate the colony...
  11. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay E Reeder; Fiscal Year: 2010
    ..The phenotype has been isolated from the transgene in FVB/N mice by selective breeding. It is inherited as an autosomal dominant trait, is seen in both males and females and no precipitating event (..
    Douglas M Tollefsen; Fiscal Year: 2010
    ..b>Breeding studies will be done to determine whether neonatal mortality is related to maternal, paternal, or fetal HCII ..
  13. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..The first mouse line (73.12xffIKKb) is obtained by breeding a GFAP-Cre line developed in Dr...
  14. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..2-HC rats will be generated by breeding 1-HC female rats with normal male rats...
  15. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2013
    ..Finally, we will establish long-term breeding herds...
  16. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    ADIL YOUSIF SHAMOO; Fiscal Year: 2012
    ..Hospitals and farms can therefore act as breeding grounds and reservoirs for the transfer of drug resistance genes into the general community...
  17. Modulation of Ca Control of Cardiac Myofibrils
    R John Solaro; Fiscal Year: 2013
    ..In Aim #3 our approach is to determine whether cross-breeding a familial DCM mouse model linked to a tropomyosin mutation with the miR208a-KO mouse is able to rescue the DCM ..
  18. Pathological Evaluation of a Cystic Fibrosis Ferret Model
    John F Engelhardt; Fiscal Year: 2010
    ..for easier propagation without intestinal obstruction, and establishment of a corporate partnership for breeding and disseminating this model to the research community-will greatly impact research on the multi-organ aspects of ..
  19. Mechanisms of glucagon-like peptide 1 (GLP-1) in fatty liver disease
    Frank A Anania; Fiscal Year: 2013
    ..establishing 1) a dietary model capable of inducing NAFLD and hepatocyte insulin resistance;and 2) successful breeding of a tissue-specific knockout mouse for the GLP-1 receptor (GLP-1R) in the liver, GLP-1RCre+/flox/flox confirmed ..
  20. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ..b>Breeding females will be fed one of two diets containing either a high percentage of omega 6 or a high percentage of omega ..
    Guojun Bu; Fiscal Year: 2013
    ..if overexpressed LRP1 in mouse brains is sufficient to rescue lipid and synaptic impairments in apoE4-TR mice by breeding apoE3-TR and apoE4-TR mice with LRP1 transgenic mice...
  22. The evolutionary and molecular mechanisms underlying sperm performance in an emer
    Heidi S Fisher; Fiscal Year: 2013
    ..In species in which females mate multiple times over a breeding season, there is intense competition between ejaculates of different males for fertilization of her eggs...
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
    ..diets through dietary adjuvants, upregulation of intestinal uptake by moderate vitamin A deficiency, and cross breeding of various transgenic mice targeted to the carotenoid metabolic pathways...
    Thomas J Rowell; Fiscal Year: 2011
    ..from the wild for research purposes;and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP)...
  25. Symbiotic Rickettsia Species as a Model System for the Study of Folate Biosynthes
    Jianmin Zhong; Fiscal Year: 2012
    ..Arthropods that feed primarily or entirely on blood are virtually a breeding ground for these types of partnerships because vertebrate blood rarely contains sufficient quantities of ..
    Eric J Nestler; Fiscal Year: 2013
    ..The Transgenic Core (PI, Eric Nestler) is responsible for breeding the many lines of transgenic and knockout mice, and for constructs for viral-mediated gene transfer, to be ..
  27. Genetic determinants of susceptibility to mycobacterial infections
    Philippe Gros; Fiscal Year: 2013
    ..characterizing a series of congenic and subcongenic mouse strains, in which Trl3 has been isolated by selective breeding. The minimal genetic interval will be carefully scrutinized for the presence of positional candidates that will ..
  28. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..We will use genetically engineered mice that express Cre recombinase and GFP under the Kiss1 promoter. Breeding to homozygosity would lead to Kiss1 deficient (but Cre/GFP positive) mice...
  29. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..In 1986 the National Institutes of Health created the Chimpanzee Breeding and Research Program (CBRP) to insure that a chimpanzee population in the United States was available for use in ..
  30. The Biosynthesis of Anandamide
    Dale G Deutsch; Fiscal Year: 2010
    ..major limitation of a conventional NAPE-PLD-/-, we propose to develop an adult conditional NAPE-PLD knockout by breeding mice in which the exon encoding the enzyme's catalytic residues is floxed...
  31. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
    ..Pilot funding is required because genotyping, breeding, housing, and testing of these mice in the immunohistochemical and behavioral assays proposed require an ..
  32. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    ..will create new genetically modified mouse strains, maintain strains shared by all projects, and assist with breeding and genotyping for genetic studies...
  33. A semi field trial test on efficacy of transgenic antimalarial biocontrol fungi
    Raymond J St Leger; Fiscal Year: 2013
    ..will consist of experimental huts (mimicking traditional housing), sugar sources (plants) for adults and created breeding sites (plastic containers), enclosed in a greenhouse frame with walls of mosquito netting to allow exposure to ..
  34. Aflatoxin B1 hepatocarcinogenesis in the mGSTA3-/- mouse
    Stewart Sell; Fiscal Year: 2013
    ..The models will be designed to target oval cells, mimic initiation + promotion protocols and include cross-breeding with chronic hepatitis-prone transgenic mice...
  35. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
    ..ROCKs in smooth muscle during OVA challenge using smooth muscle specific ROCK1 and ROCK2 knockdowns generated by breeding conditional ROCK1 and ROCK2 knockout mice (floxed mice) to transgenic mice expressing Cre recombinase under ..
  36. Defining a clinically relevant time point for astrocyte targeted therapy in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..Indeed, it has been shown that the reduction of mtSOD1 expression in astrocytes by breeding transgenic mice contacting the floxed mtSOD1 with mice expressing Cre from the glial fibrillary acidic protein (..
    ANTHONY PEGG; Fiscal Year: 2009
    ..the presence of spermine in their diets;and preliminary results indicating that restoring a source of spermine by breeding female Gy carrier mice with CAG-SpmS mice restores normal growth and fertility to these mice despite the ..
  38. The Ecology, Emergence and Pandemic Potential of Nipah virus in Bangladesh
    Peter Daszak; Fiscal Year: 2012
    ..NiV spillover risk from bats to humans is a factor of fruit bat population biology, especially their synchronous breeding patterns...
  39. Transgenic Mouse Models of FUS/TLS-Mediated Amyotrophic Lateral Sclerosis
    Zuoshang Xu; Fiscal Year: 2010
    ..This strategy will allow the selection and breeding of founder animals even if the mutant gene is highly toxic...
  40. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..many animals manifest marked seasonal changes in physiology and behavior, such as those related to hibernation, breeding and migration...
  41. Construct novel influenza A (H1N1) virus chimeric HA genes for development of bro
    VICTOR CHESTER HUBER; Fiscal Year: 2010
    ..spread of novel swine-origin H1N1 influenza viruses, this proposed study will test the feasibility of a molecular breeding (DNA shuffling) approach to create novel HA genes of influenza H1N1 viruses for development of broadly protective ..
  42. Endothelial NOS by protein to protein interactions
    William C Sessa; Fiscal Year: 2013
    ..Interestingly, breeding ApoE/ Cav-1 KO double KO (dKO) mice to EC specific Cav-1 transgenic mice (Cav-1 RC) to reconstitute Cav-1 and ..
  43. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2012
    ..In addition animal breeding colonies were set up for 4 strains of genetically-modified mice from unapproved sources...
  44. College of Medicine Phoenix Campus Vivarium Phase I Construction
    William M Crist; Fiscal Year: 2010
    ..Rooms will be provided for breeding of transgenic mice lines, specialized behavioral assays of rats and mice, animal biosafety level 2 (ABSL2) ..
  45. Development & Characterization of Tyrosinase Epitope Specific TCR Transgenic Mice
    Shikhar Mehrotra; Fiscal Year: 2010
    ..This objective will be accomplished by breeding our TIL1383i/Tg mice with commercially available HLA-A2 and HLA-A/H2-Db mice...
  46. The Role of Heme Oxygenase-1 in the Immune Response
    James F George; Fiscal Year: 2013 the PIs, including i) a transgenic floxed HO-1 mouse strain permitting selective expression of HO-1 by cross-breeding with the appropriate cre recombinants;a CD11c-DC specific HO-1 overexpressing strain;ii) a GFP+ HO-1-/- mouse ..
  47. Genetics and biology of a viable mutant mouse with dystonic movements
    Kathleen J Sweadner; Fiscal Year: 2013
    ..with high penetrance;adult-onset;a lack of incapacitating deficits;lifespan of at least 18 months so far;and easy breeding. Although the symptoms are severe, a key feature is that the mice are capable of normal walking and running on a ..
  48. Sound Source Segregation
    Mark A Bee; Fiscal Year: 2013
    ..calls of individual males from the overlapping signals of other males and the general din of noise in a large breeding chorus...
  49. Cortisol regulation of perinatal adipose tissue and sheep neonatal leptin peak
    Stephen P Ford; Fiscal Year: 2013 1) C;ewes fed 100% diet pre-, during and after pregnancy or 2) MO, ewes fed 150% diet from 60 d before breeding, during and after pregnancy...
  50. Astrocyte Function in Genetic Mouse Models of Autism Spectrum Disorders
    Bruce D Trapp; Fiscal Year: 2013
    ..b>Breeding of these fluorescently tagged astrocytes into genetic models of ASDs will permit astrocyte isolation by ..
  51. An Integrated Nano-Cell Delivery Platform of Theranostics for Lung Cancers
    Subhra Mohapatra; Fiscal Year: 2013
    ..In this aim, it is planned to establish a model of spontaneous lung cancer by breeding LSL-K-ras- G12D mice with CC10- Cretg mice to generate CC10-Cre-LSL-K-ras G12D mice and to evaluate the efficacy ..
  52. TILLING Wheat for Reduced Celiac Disease Causing Proteins
    CHARLES PAUL MOEHS; Fiscal Year: 2010
    ..organism) technique invented by an Arcadia Biosciences scientist that is a target-selected variation of mutation breeding. During STTR phase I research we have also determined the importance of a DNA 5- methylcytosine deglycosylase for ..
  53. Role of Calpastatin in mutant SOD1-mediated motor neuron disease
    Mala V Rao; Fiscal Year: 2010
    ..We will use mouse breeding techniques, Southern Blotting, polymerase chain reactions, immunoblotting, immunocytochemistry, electron ..
  54. The Impact of Maternal Health and Diet on Development of Fetal Metabolic Systems
    KENT L R THORNBURG; Fiscal Year: 2013
    ..For these studies, breeding NHPs will be chronically maintained on a diet high in fats and calories (HFD)...
    Peter J Newman; Fiscal Year: 2013
    ..The Transgenic/Knockout Mouse Core will assist with vector design, transgenic mouse production, multi-trait breeding, and animal husbandry...
    Kaiyi Li; Fiscal Year: 2012 oncogenic stress (c-myc), we will generate the double mutant mice (Alb- cMyc/BRIT1flox/flox/Alb-Cre) by breeding the BRIT1 conditional knockout with Alb-cMyc transgenic mice...
  57. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2013
    ..C57Lc1 recombinant congenic strain Lc1(1.34Mb) that contains the 1.34Mb of interest by intercross breeding (NZM2328X507-2)F1 X (NZM2328X507-2)F1;Specific Aim 2: To identify a set of contiguous overlapping genomic clones (..
    Herbert W Virgin; Fiscal Year: 2012
    ..a significant proportion of laboratory mice, requiring a significant investment in developing a closed mouse breeding colony to generate non-immune mice with which to perform immunology and pathogenesis experiments...
  59. Genetic basis of sperm competition in Peromyscus
    Heidi S Fisher; Fiscal Year: 2010
    ..In species where females mate multiple times over a breeding season, there is intense competition between ejaculates of different males for fertilization of her eggs...
  60. Epigenetics underlies long-term risk of relapse during abstinence
    Kristine M Wiren; Fiscal Year: 2013
    ..contributions, both sexes of an animal model with widely divergent responses to alcohol derived by selective breeding, the Withdrawal Seizure-Resistant (WSR) and Withdrawal Seizure-Prone (WSP) lines, were analyzed...
  61. STAT3 Functional Defects and a Novel Therapeutic Approach for Hyper IgE Syndrome
    Hans Ochs; Fiscal Year: 2009
    ..Finally, we have established a breeding colony of WAS deficient (KO) mice that will allows us to study in vivo the immune defect caused by mutations of ..
  62. Physiologic role of the gamma epithelial sodium channel subunit in the kidney
    Donald E Kohan; Fiscal Year: 2010
    ..b>Breeding of these animals will result in distal nephron-knockout of ? ENaC...
  63. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    ..the role that North American migratory passerines play in the dispersion of avian influenza strains between breeding sites in Canada and the U.S. and wintering sites in Mexico and Central and South America...
  64. Ochlerotatus japonicus: Ecology of an Invasive Mosquito
    RICHARD FALCO; Fiscal Year: 2005
    ..Oc. japonicus uses a wide variety of breeding sites that encompass urban, suburban, and rural habitats, including those inhabited by Culex pipiens, the primary ..
    ROBERT DRUILHET; Fiscal Year: 2000
    ..The initial objective is to establish a breeding colony of SPF defined feral pigtail macaques capable of producing subsequent breeder stock of native born SPF M...
    RONALD SCHUELER; Fiscal Year: 1993
    Maintain and provide for the care and breeding of genetically defined rabbits (approximately 600 past the age of weaning). House rabbits in cage meeting Government requirements and provided by the Government...
    LAUREN RITERS; Fiscal Year: 2003
    ..During the breeding season, song in male starlings (Sturnus vulgaris) is observed prior to pair formation and copulation and likely ..
    M Izard; Fiscal Year: 1999
    ..drug therapy and for basic sciences research, requiring that the government establish and maintain macaque breeding colonies free of the known simian retroviruses and Herpes B virus...
  69. A Novel Device Design for Sperm Cryopreservation
    ERIK WOODS; Fiscal Year: 2009
    ..However, maintenance of these lines by standard breeding techniques is producing unsustainable pressure on facilities and budgets...
  70. Novel accelerated in vitro breeding for phytoremediation
    MIHALY CZAKO; Fiscal Year: 2007
    ..The long-term goal of the collaboration between the USC and Southern Sun BioSystems is to create a plant breeding and remediation technology-development center which would supply hardware, protocols for breeding-selection and ..
    Fred Turek; Fiscal Year: 2001
    ..change in day length is the major environmental factor regulating the timing of reproduction in many seasonally breeding mammals...
    Charles Snowdon; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The cotton-top tamarin is a cooperatively breeding monkey living in family groups. Infant care taking is divided among group members with fathers and older siblings doing most infant carrying...