renal dialysis

Summary

Summary: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

Top Publications

  1. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
  2. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
  3. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
  4. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
  5. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
  6. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
  7. ncbi Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
  8. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
  9. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
  10. ncbi Serum phosphate levels and mortality risk among people with chronic kidney disease
    Bryan Kestenbaum
    Veterans Affairs Puget Sound Health Care System, Division of Nephrology, Mail Stop 111A, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Am Soc Nephrol 16:520-8. 2005

Research Grants

Detail Information

Publications340 found, 100 shown here

  1. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  2. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
    ..Disorders of mineral metabolism are independently associated with mortality and morbidity associated with cardiovascular disease and fracture in hemodialysis patients...
  3. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
    ..Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established...
  4. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  5. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  6. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
    ..Statins reduce the incidence of cardiovascular events in patients at high cardiovascular risk. However, a benefit of statins in such patients who are undergoing hemodialysis has not been proved...
  7. ncbi Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
    ..Paricalcitol, a new vitamin D analogue, appears to lessen the elevations in serum calcium and phosphorus levels, as compared with calcitriol, the standard form of injectable vitamin D...
  8. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
    ....
  9. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
    ..01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value...
  10. ncbi Serum phosphate levels and mortality risk among people with chronic kidney disease
    Bryan Kestenbaum
    Veterans Affairs Puget Sound Health Care System, Division of Nephrology, Mail Stop 111A, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Am Soc Nephrol 16:520-8. 2005
    ..Mortality risk increased linearly with each subsequent 0.5-mg/dl increase in serum phosphate levels. Elevated serum phosphate levels were independently associated with increased mortality risk among this population of patients with CKD...
  11. pmc Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients
    Nazanin Noori
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin J Am Soc Nephrol 5:2258-68. 2010
    ..We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean body mass (LBM), has stronger association with clinical outcomes than triceps skinfold (TSF), a surrogate of fat mass...
  12. ncbi Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
    ..Randomized clinical trials would permit definitive conclusions...
  13. ncbi Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Francesca Tentori
    Arbor Research Collaborative for Health, University of Michigan, Ann Arbor, MI 48103, USA
    Am J Kidney Dis 52:519-30. 2008
    ....
  14. ncbi Vitamin D levels and early mortality among incident hemodialysis patients
    M Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 72:1004-13. 2007
    ..Our study shows that among incident hemodialysis patients, vitamin D deficiency is common, correlates poorly with other components of mineral metabolism and is associated with increased early mortality...
  15. pmc Osteoprotegerin/RANKL axis and progression of coronary artery calcification in hemodialysis patients
    Abdullah Ozkok
    Istanbul Faculty of Medicine, Department of Internal Medicine and Nephrology, Istanbul University, Istanbul, Turkey
    Clin J Am Soc Nephrol 7:965-73. 2012
    ..This prospective study investigated the relationship between serum osteoprotegerin, receptor activator of NF-κB ligand, inflammatory markers, and progression of coronary artery calcification score...
  16. ncbi Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002
    ..The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain...
  17. ncbi Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 70:771-80. 2006
    ....
  18. ncbi Incidence, prevalence and mortality trends of dialysis end-stage renal disease in Taiwan from 1990 to 2001: the impact of national health insurance
    Wu Chang Yang
    Division of Nephrology, Department of Medicine, Taipei Veteran General Hospital, School of Medicine, National Yang Ming University Taipei 11217, Taiwan
    Nephrol Dial Transplant 23:3977-82. 2008
    ..Our aim was to explore the impact of NHI on the status and trends of ESRD epidemiology in Taiwan...
  19. ncbi A randomized, controlled trial of early versus late initiation of dialysis
    Bruce A Cooper
    Department of Renal Medicine, Royal North Shore Hospital, Sydney Medical School, Sydney, Australia
    N Engl J Med 363:609-19. 2010
    ..In this study, conducted at 32 centers in Australia and New Zealand, we examined whether the timing of the initiation of maintenance dialysis influenced survival among patients with chronic kidney disease...
  20. ncbi ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends
    Aileen Grassmann
    Nephrol Dial Transplant 20:2587-93. 2005
  21. ncbi Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients
    S K Ganesh
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48103, USA
    J Am Soc Nephrol 12:2131-8. 2001
    ..More vigorous measures to reduce the prevalence of these factors in HD patients may result in improved survival...
  22. ncbi Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 26:1662-9. 2011
    ..In addition, we assessed the impact of aortic calcification on mortality...
  23. pmc Mortality associated with low serum sodium concentration in maintenance hemodialysis
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 124:77-84. 2011
    ....
  24. ncbi Cardiovascular and noncardiovascular mortality among patients starting dialysis
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 104, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 302:1782-9. 2009
    ..Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population...
  25. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
  26. ncbi An improved comorbidity index for outcome analyses among dialysis patients
    Jiannong Liu
    United States Renal Data System Coordinating Center, 914 South 8th Street, Minneapolis, MN 55404, USA
    Kidney Int 77:141-51. 2010
    ..Our index performance was almost identical to the individual comorbid conditions regarding model fit, predictive ability, and effect on inference, and it outperformed the widely used Charlson Comorbidity Index...
  27. ncbi Association of Malnutrition-Inflammation Score with quality of life and mortality in hemodialysis patients: a 5-year prospective cohort study
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, CA, USA
    Am J Kidney Dis 53:298-309. 2009
    ..We hypothesized that MIS risk stratification of hemodialysis (HD) patients in predicting outcomes is better than its components or laboratory markers of inflammation...
  28. ncbi Cancer in patients on dialysis for end-stage renal disease: an international collaborative study
    P Maisonneuve
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Lancet 354:93-9. 1999
    ..The aim of this study was to examine the risk of cancer in a large cohort of patients treated by dialysis but not transplantation...
  29. ncbi International comparison of the relationship of chronic kidney disease prevalence and ESRD risk
    Stein I Hallan
    Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
    J Am Soc Nephrol 17:2275-84. 2006
    ..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway...
  30. ncbi Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
    Kidney Int 63:793-808. 2003
    ..It is possible that new standards or goals for such traditional risk factors as body mass, serum cholesterol, and blood pressure should be considered for these individuals...
  31. ncbi Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients
    Mohamed M Nasrallah
    Department of Nephrology, School of Medicine, Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Nephrol Dial Transplant 25:2679-85. 2010
    ..We conducted this study to investigate the relationship between FGF-23 and aortic calcification in a standard haemodialysis setting...
  32. pmc A comparison of SF-36 and SF-12 composite scores and subsequent hospitalization and mortality risks in long-term dialysis patients
    Eduardo Lacson
    Clinical Sciences, Epidemiology, and Research, Fresenius Medical Care, North America, Waltham, Massachusetts 02451 1457, USA
    Clin J Am Soc Nephrol 5:252-60. 2010
    ..The study compared physical and mental component summary (PCS/MCS) scores from the SF-36 with those from the embedded SF-12 in a national cohort of dialysis patients...
  33. ncbi Serum beta-2 microglobulin levels predict mortality in dialysis patients: results of the HEMO study
    Alfred K Cheung
    VA Salt Lake City Healthcare System and Department of Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    J Am Soc Nephrol 17:546-55. 2006
    ..05 to 1.19; P = 0.001), after adjustment for residual kidney urea clearance and number of prestudy years on dialysis. This association is supportive of the potential value of beta(2)M as a marker to guide chronic hemodialysis therapy...
  34. ncbi Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Nephrol Dial Transplant 19:179-84. 2004
    ..We hypothesized that treatment with vitamin D(3) may be beneficial for survival in patients with end-stage renal disease (ESRD)...
  35. ncbi Overview of regular dialysis treatment in Japan (as of 31 December 2008)
    Shigeru Nakai
    Renal Data Registry Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 14:505-40. 2010
    ..The risk of becoming HCV-positive was high in patients with low serum creatinine, serum albumin, and serum total cholesterol levels, and/or a low body mass index before beginning dialysis...
  36. ncbi Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomes
    Dominique Joly
    Nephrology Unit, Necker Hospital and Université René Descartes Paris V, Paris, France
    J Am Soc Nephrol 14:1012-21. 2003
    ....
  37. ncbi Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006
    ..4% in 1988 to 26.6% in 2002 (P < 0.001). This study provides evidence from an administrative database that the incidence of ARF and ARF-D is rising. Despite an increase in the degree of comorbidity, in-hospital mortality has declined...
  38. ncbi Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study
    Eric W Young
    Department of Veterans Affairs Medical Center, and Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA
    Kidney Int 67:1179-87. 2005
    ..Altered mineral metabolism contributes to bone disease, cardiovascular disease, and other clinical problems in patients with end-stage renal disease...
  39. pmc Hemodialysis affects phenotype and proliferation of CD4-positive T lymphocytes
    Katarzyna A Lisowska
    Department of Pathophysiology, Medical University of Gdansk, Debinki 7, 80 211, Gdansk, Poland
    J Clin Immunol 32:189-200. 2012
    ..CD4(+) T lymphocytes of PD patients and healthy controls were characterized by similar cell cycle parameters. Our study shows that repeated hemodialysis procedure influences phenotype and proliferation parameters of CD4(+) T lymphocytes...
  40. ncbi Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:864-81. 2003
    ..Clinical trials focusing on MICS and its possible causes and consequences are urgently required to improve poor clinical outcome in dialysis patients...
  41. ncbi Association of comorbid conditions and mortality in hemodialysis patients in Europe, Japan, and the United States: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    David A Goodkin
    Amgen Inc, Thousand Oaks, California, USA
    J Am Soc Nephrol 14:3270-7. 2003
    ..Adjustments for the observed variability will allow study of association between practice patterns and outcomes...
  42. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  43. ncbi Predialysis serum sodium level, dialysate sodium, and mortality in maintenance hemodialysis patients: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Manfred Hecking
    Arbor Research Collaborative for Health, Ann Arbor, MI 48104, USA
    Am J Kidney Dis 59:238-48. 2012
    ..Predialysis serum sodium concentrations recently have been linked to patient characteristics and outcomes in hemodialysis patients and may have implications for the dialysate sodium prescription...
  44. ncbi Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease
    Carmine Zoccali
    National Research Council Center of Clinical Physiology, Reggio Calabria, Italy
    J Am Soc Nephrol 13:134-41. 2002
    ..Furthermore, ADPN is related to several metabolic risk factors in a manner consistent with the hypothesis that this protein acts as a protective factor for the cardiovascular system...
  45. ncbi High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients
    Guillaume Jean
    Centre de Rein Artificiel, Tassin La Demi Lune, France
    Nephrol Dial Transplant 24:2792-6. 2009
    ....
  46. ncbi C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients
    J Y Yeun
    Department of Medicine, Division of Nephrology, and the Department of Statistics, University of California Davis, Sacramento 95817, USA
    Am J Kidney Dis 35:469-76. 2000
    ..The acute-phase response or the cause of the acute-phase response is largely responsible for the effect of hypoalbuminemia on mortality in HD patients...
  47. ncbi Impact of dialysis modality on survival of new ESRD patients with congestive heart failure in the United States
    Austin G Stack
    Division of Renal Diseases and Hypertension, Department of Internal Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Kidney Int 64:1071-9. 2003
    ....
  48. ncbi International differences in dialysis mortality reflect background general population atherosclerotic cardiovascular mortality
    Maki Yoshino
    Renal Research Institute, 207 East 94th Street, Suite 303, New York, NY 10128, USA
    J Am Soc Nephrol 17:3510-9. 2006
    ..Genetic and environmental factors may underlie these differences...
  49. ncbi Octogenarians and nonagenarians starting dialysis in the United States
    Manjula Kurella
    Division of Nephrology, University of California, San Francisco, CA 94118 1211, USA
    Ann Intern Med 146:177-83. 2007
    ....
  50. pmc Nonrecovery of kidney function and death after acute on chronic renal failure
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 4:891-8. 2009
    ..Relatively little is known about clinical outcomes, especially long-term outcomes, among patients who have chronic kidney disease (CKD) and experience superimposed acute renal failure (ARF; acute on chronic renal failure)...
  51. ncbi Clinical consequences of an individualized dialysate sodium prescription in hemodialysis patients
    Flavio M de Paula
    Division of Nephrology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Kidney Int 66:1232-8. 2004
    ....
  52. ncbi Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients
    E D Siew
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Kidney Int 71:146-52. 2007
    ..This study demonstrates that insulin resistance is evident in non-diabetic dialysis patients, is associated with skeletal muscle protein breakdown, and represents a novel target for intervention in uremic wasting...
  53. ncbi Predictors of early mortality among incident US hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Brian D Bradbury
    Department of Global Epidemiology, Amgen, Inc, Thousand Oaks, California 91320, USA
    Clin J Am Soc Nephrol 2:89-99. 2007
    ..Inadequate predialysis nephrology care was strongly associated with mortality during this period, highlighting the potential benefits of contact with a nephrologist at least 1 mo before HD initiation...
  54. ncbi Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
    J Zimmermann
    Department of Medicine, University Clinic Würzburg, Germany
    Kidney Int 55:648-58. 1999
    ..We hypothesize that several of the classic, as well as nontraditional, cardiovascular risk factors may respond to acute phase reactions. An activated acute phase response may influence or predict cardiovascular risk...
  55. ncbi Dialyzer membrane permeability and survival in hemodialysis patients
    Philippe Chauveau
    Departement de Nephrologie, Centre Hospitalier Universitaire and Université Bordeaux 2, Bordeaux, France
    Am J Kidney Dis 45:565-71. 2005
    ..Information on dialysis membrane and erythropoietin use had to be evaluated in an additional follow-up...
  56. ncbi Ankle brachial index as a predictor for mortality in patients with chronic kidney disease and undergoing haemodialysis
    Szu Chia Chen
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Nephrology (Carlton) 15:294-9. 2010
    ..The aim of this study was to investigate the predictors for mortality by using ABI value in patients with CKD and undergoing haemodialysis in Taiwan...
  57. ncbi Chronic dialysis and death among survivors of acute kidney injury requiring dialysis
    Ron Wald
    Division of Nephrology, St Michael s Hospital, 61 Queen St East, 9 140, Toronto, ON M5C 2T2, Canada
    JAMA 302:1179-85. 2009
    ..Severe acute kidney injury among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who survive to hospital discharge...
  58. ncbi Ankle-brachial blood pressure index predicts all-cause and cardiovascular mortality in hemodialysis patients
    Kumeo Ono
    Kan etsu Chuo Hospital, Maebashi, Gunma, Japan
    J Am Soc Nephrol 14:1591-8. 2003
    ..04 [1.14 to 8.12] for all-cause and cardiovascular mortality, respectively). Thus, the present findings validate ABPI as a powerful and independent predictor for all-cause and cardiovascular mortality among hemodialysis patients...
  59. pmc The associations of social support and other psychosocial factors with mortality and quality of life in the dialysis outcomes and practice patterns study
    Aurélie Untas
    Laboratoire de Psychologie Santé et Qualité de vie EA 4139, Universite de Bordeaux, Bordeaux, France
    Clin J Am Soc Nephrol 6:142-52. 2011
    ..This study aimed to investigate the influence of social support and other psychosocial factors on mortality, adherence to medical care recommendations, and physical quality of life among hemodialysis patients...
  60. ncbi Impact of the clinical conditions at dialysis initiation on mortality in incident haemodialysis patients: a national cohort study in Taiwan
    Shang Jyh Hwang
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nephrol Dial Transplant 25:2616-24. 2010
    ..We studied factors potentially related to the mortality in incident haemodialysis (HD) patients...
  61. ncbi Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Perit Dial Int 30:72-9. 2010
    ..Relative to hemoglobin A(1c) (HbA(1c)), percentage of glycated albumin (GA%) more accurately reflects recent glycemic control in diabetic hemodialysis (HD) patients...
  62. pmc The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis
    Kamyar Kalantar-Zadeh
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Mayo Clin Proc 85:991-1001. 2010
    ..To determine whether dry weight gain accompanied by an increase in muscle mass is associated with a survival benefit in patients receiving maintenance hemodialysis (HD)...
  63. ncbi Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Donna L Mapes
    Amgen, Inc, Thousand Oaks, California, USA
    Kidney Int 64:339-49. 2003
    ..We also compared HRQOL measures with serum albumin regarding their power to predict outcomes...
  64. ncbi The prevalence of symptoms in end-stage renal disease: a systematic review
    Fliss E M Murtagh
    Department of Palliative Care and Policy, Kings College London, London, UK
    Adv Chronic Kidney Dis 14:82-99. 2007
    ..The need for greater recognition of and research into symptom prevalence and causes, and interventions to alleviate them, is urgent...
  65. pmc Clinical practices and outcomes in elderly hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Bernard Canaud
    Lapeyronie University Hospital, CHU Montpellier University, Montpellier, France
    Clin J Am Soc Nephrol 6:1651-62. 2011
    ..The Dialysis Outcomes and Practice Patterns Study (DOPPS) provides a unique opportunity to assess dialysis practices and associated outcomes among elderly versus younger patients on chronic in-center hemodialysis in 12 countries...
  66. ncbi Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    J Am Soc Nephrol 12:2759-67. 2001
    ..72 (95% confidence interval, 0.51 to 0.90) for mortality due to CV disease. These results show that a partial LVH regression in patients with ESRD had a favorable and independent effect on patients' all-cause and CV survival...
  67. ncbi Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin
    Steven Fishbane
    Winthrop University Hospital, Mineola, New York, USA
    Kidney Int 68:1337-43. 2005
    ..Therapy, however, is often observed to be associated with recurrent cyclic fluctuations in hemoglobin levels. The purpose of this analysis was to describe the phenomenology of hemoglobin cycling during rHuEPO treatment...
  68. ncbi Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients
    B Bammens
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 69:1081-7. 2006
    ..These findings may encourage nephrologists to widen their field of interest beyond the scope of small water-soluble uremic solutes and middle molecules...
  69. ncbi The differential impact of risk factors on mortality in hemodialysis and peritoneal dialysis
    Edward F Vonesh
    Baxter Healthcare Corporation, Applied Statistics Center, Round Lake, Illinois 60073, USA
    Kidney Int 66:2389-401. 2004
    ..This study was undertaken to identify key patient characteristics for which the risk of death differs by dialysis modality...
  70. ncbi A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center and the University of California Los Angeles, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 38:1251-63. 2001
    ..The MIS may be superior to the conventional SGA and the DMS, as well as to individual laboratory values, as a predictor of dialysis outcome and an indicator of MICS...
  71. pmc Biomarkers and health-related quality of life in end-stage renal disease: a systematic review
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 3:1759-68. 2008
    ....
  72. pmc Propensity-matched mortality comparison of incident hemodialysis and peritoneal dialysis patients
    Eric D Weinhandl
    Chronic Disease Research Group, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 21:499-506. 2010
    ..These data suggest that increased use of peritoneal dialysis may benefit incident ESRD patients...
  73. ncbi Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
    Geoffrey A Block
    Denver Nephrology Research Division, Denver, Colorado 80230, USA
    Kidney Int 78:578-89. 2010
    ..v. vitamin D. Definitive proof, however, of a survival advantage awaits the performance of randomized clinical trials...
  74. ncbi Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999
    Robert N Foley
    United States Renal Data System Coordinating Center, 914 South 8th Street, Suite D 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:489-95. 2005
    ..On an absolute basis, however, the high death rates of patients with CKD may reflect accelerated rates of atherosclerotic vascular disease and congestive heart failure...
  75. ncbi Predictors of the rate of decline of residual renal function in incident dialysis patients
    Maarten A M Jansen
    Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Kidney Int 62:1046-53. 2002
    ..Few studies have been published on risk factors for loss of RRF in dialysis patients. These studies were either retrospective, performed in a small number of patients, or estimated GFR without a urine collection...
  76. pmc Dialysate sodium, serum sodium and mortality in maintenance hemodialysis
    Finnian R Mc Causland
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nephrol Dial Transplant 27:1613-8. 2012
    ....
  77. pmc Hemodialysis-induced cardiac injury: determinants and associated outcomes
    James O Burton
    Department of Renal Medicine, Derby City Hospital, Derby, UK
    Clin J Am Soc Nephrol 4:914-20. 2009
    ..HD may initiate and drive the same process. In this study, we examined the prevalence and associations of HD-induced repetitive myocardial injury and long-term effects on LV function and patient outcomes...
  78. ncbi The cost of renal dialysis in a UK setting--a multicentre study
    Keshwar Baboolal
    Department of Nephrology and Transplantation, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK
    Nephrol Dial Transplant 23:1982-9. 2008
    ..We have therefore estimated the cost of different dialysis modalities in the Cardiff and Vale NHS Trust and six other hospitals in the UK...
  79. ncbi Coronary artery calcification in patients with CRF not undergoing dialysis
    Domenico Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Am J Kidney Dis 44:1024-30. 2004
    ..Nearly all data about CAC relate to patients on dialysis therapy. This study evaluates the prevalence and extent of CAC in patients with chronic renal failure (CRF) not yet on dialysis therapy...
  80. ncbi Secular trends in cardiovascular mortality rates of patients receiving dialysis compared with the general population
    Matthew A Roberts
    Department of Nephrology, Austin Health, Melbourne, Australia
    Am J Kidney Dis 58:64-72. 2011
    ..We hypothesized that cardiovascular mortality rates in dialysis patients, which are higher than in the general population, have not decreased as much as those in the general population...
  81. ncbi Early start of dialysis: a critical review
    Steven Rosansky
    Dorn Research Institute, William Jennings Bryan Dorn Veterans Hospital, University of South Carolina, Arnold School of Public Health, Columbia, South Carolina 29206, USA
    Clin J Am Soc Nephrol 6:1222-8. 2011
    ..73 m(2), if accompanied by uremia symptoms or fluid management issues...
  82. pmc Current status of dialysis therapy in Korea
    Dong Chan Jin
    Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea
    Korean J Intern Med 26:123-31. 2011
    ..Mean Kt/V was 1.38 in male patients and 1.65 in female patients. Fifth, the overall 5-year survival rate of male patients undergoing dialysis was 65.4% and that of female patients was 67.4%...
  83. pmc Hemodialysis vascular access modifies the association between dialysis modality and survival
    Jeffrey Perl
    Division of Nephrology, St Michael s Hospital and The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Am Soc Nephrol 22:1113-21. 2011
    ..In conclusion, the use of CVCs in incident HD patients largely accounts for the early survival benefit seen with PD...
  84. ncbi Mortality risk among hemodialysis patients receiving different vitamin D analogs
    F Tentori
    Dialysis Clinic Inc, Albuquerque, New Mexico, USA
    Kidney Int 70:1858-65. 2006
    ..2 (1.1-1.3)). Mortality in doxercalciferol- and paricalcitol-treated patients was virtually identical. Differences in survival between vitamin D2 and D3 may be smaller than previously reported...
  85. pmc Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality
    Jennifer E Flythe
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 79:250-7. 2011
    ..Hence, higher ultrafiltration rates in hemodialysis patients are associated with a greater risk of all-cause and cardiovascular death...
  86. ncbi Calcium, phosphorus, PTH and death rates in a large sample of dialysis patients from Latin America. The CORES Study
    Manuel Naves-Díaz
    Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Universidad de Oviedo, Julian Claveria s n, 33006 Oviedo, Spain
    Nephrol Dial Transplant 26:1938-47. 2011
    ..Mineral metabolism parameters may play a role in the survival of patients with chronic kidney disease (CKD)...
  87. ncbi Epidemiology, surveillance, and prevention of hepatitis C virus infections in hemodialysis patients
    Priti R Patel
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Atlanta, GA, USA
    Am J Kidney Dis 56:371-8. 2010
    ..This article describes the current epidemiology of HCV infection in US maintenance hemodialysis patients and prevention practices to decrease its incidence and transmission...
  88. ncbi Inflammation in end-stage renal disease--what have we learned in 10 years?
    Juan J Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Semin Dial 23:498-509. 2010
    ..Causes and consequences of inflammation, genetic heritability of the inflammatory response, implications on outcome prognostication, and contemporary therapeutic evidence are some of the various topics discussed...
  89. pmc Functional status of elderly adults before and after initiation of dialysis
    Manjula Kurella Tamura
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    N Engl J Med 361:1539-47. 2009
    ..It is unclear whether functional status before dialysis is maintained after the initiation of this therapy in elderly patients with end-stage renal disease (ESRD)...
  90. ncbi Frequent Hemodialysis Network (FHN) randomized trials: study design
    R S Suri
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Kidney Int 71:349-59. 2007
    ....
  91. ncbi Travel time to dialysis as a predictor of health-related quality of life, adherence, and mortality: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Louise M Moist
    Division of Nephrology, London Health Sciences Center and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Am J Kidney Dis 51:641-50. 2008
    ..This study evaluated the effect of self-reported 1-way travel time to hemodialysis on mortality, health-related quality of life (HR-QOL), adherence, withdrawal from dialysis therapy, hospitalization, and transplantation...
  92. ncbi Effect of the ownership of dialysis facilities on patients' survival and referral for transplantation
    P P Garg
    Robert Wood Johnson Clinical Scholars Program, Department of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 341:1653-60. 1999
    ..Therefore, we examined the effect of for-profit ownership of dialysis facilities on patients' survival and referral for possible transplantation...
  93. ncbi Early start of hemodialysis may be harmful
    Steven J Rosansky
    Dorn Research Institute, Wm Jennings Bryan Dorn Veterans Hospital, 526 N Trenholm Rd, Columbia, SC 29206, USA
    Arch Intern Med 171:396-403. 2011
    ..The current study examines a relatively "healthy" dialysis cohort to minimize confounding issues and determine whether early initiation of hemodialysis is associated with a survival benefit or harm...
  94. ncbi Interferon-gamma release assays versus tuberculin skin testing for detection of latent tuberculosis in chronic haemodialysis patients
    Pierre Alain Triverio
    Division of Nephrology, Geneva University Hospital, 1211 Geneva 14, Switzerland
    Nephrol Dial Transplant 24:1952-6. 2009
    ..End stage renal disease increases the risk of reactivating latent tuberculosis (LTBI). Interferon-gamma release assays (IGRA) are an alternative to the tuberculin skin test (TST) for detecting LTBI...
  95. ncbi Mortality caused by sepsis in patients with end-stage renal disease compared with the general population
    M J Sarnak
    Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 58:1758-64. 2000
    ..Although it is intuitive to believe that mortality caused by sepsis may be higher in patients with ESRD compared with the general population (GP), no such data are currently available...
  96. ncbi Recombinant human erythropoietin treatment of chronic renal failure patients normalizes altered phenotype and proliferation of CD4-positive T lymphocytes
    Katarzyna A Lisowska
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Artif Organs 34:E77-84. 2010
    ..Our study confirms that rhEPO treatment normalizes activation parameters of CD4(+) T lymphocytes and their proliferative capacity, which could explain earlier described immunomodulatory effects of rhEPO in patients suffering from CRF...
  97. ncbi Frequencies of hepatitis B and C infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: analysis of registry data
    David W Johnson
    Australia and New Zealand Dialysis and Transplant Registry, Discipline of Public Health, University of Adelaide, Adelaide, Australia
    Nephrol Dial Transplant 24:1598-603. 2009
    ..The aim of the present investigation was to evaluate the rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in peritoneal dialysis (PD) and haemodialysis (HD) patients in the Asia-Pacific region...
  98. ncbi Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    J Am Soc Nephrol 16:2180-9. 2005
    ..Normalization of hemoglobin in incident hemodialysis patients does not have a beneficial effect on cardiac structure, compared with partial correction...
  99. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
    ..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
  100. ncbi The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer
    D Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Kidney Int 72:1255-61. 2007
    ..Our study shows that sevelamer treatment should not be restricted to dialysis patients; however, a larger study should be undertaken to confirm these results...
  101. ncbi Neutrophil gelatinase-associated lipocalin in dialyzed patients is related to residual renal function, type of renal replacement therapy and inflammation
    Jolanta Malyszko
    Department of Nephrology, Medical University, Bialystok, Poland
    Kidney Blood Press Res 32:464-9. 2009
    ..A cross-sectional study was performed to assess NGAL in serum, urine and ultrafiltrate in relation to the type of renal replacement therapy and NGAL correlations with renal function and markers of inflammation...

Research Grants64

  1. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    ..to other urologic complications, such as incontinence, urinary tract infection, renal damage and consequent renal dialysis or transplantation which can lead to recurrent and costly hospitalization...
  2. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..requesting funds to support the EIP cooperative agreement Healthcare Associated Infections Program End Stage Renal Dialysis Blood Stream Surveillance special pilot project...
  3. Phase I Clinical Study Using an Antifibrotic Drug
    Weizhong Cai; Fiscal Year: 2011
    ..In addition, a clinical study of intravenously administered BB3 for safety and PK in renal dialysis patients has been completed...
  4. Bladder Voiding via Pudendal Nerve Block
    KENNETH GUSTAFSON; Fiscal Year: 2009
    ..lead to urological complications, such as incontinence, urinary tract infection, renal damage and consequent renal dialysis or transplantation can lead to recurrent and costly hospitalization...
  5. Evaluating Payment Reform and Provider Practices to Improve Health Outcomes in Ch
    Marc Turenne; Fiscal Year: 2013
    ..On 1/1/ 2011, the Medicare ESRD program will transition from fee-for-service payment to a broader PPS for many renal dialysis services...
  6. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2003
    ..of increased intracranial pressure following trauma, the treatment of disequilibrium and hypotension during renal dialysis, the monitoring of hydrational state of premature infants, and the investigation and diagnosis of orthostatic ..
  7. ADHERENCE AND ADJUSTMENT IN END-STAGE RENAL DISEASE
    Alan Christensen; Fiscal Year: 2003
    ..characteristics that influence medical regimen adherence and emotional adjustment among patients treated with renal dialysis. This will be accomplished using a longitudinal study design that considers the effects of patient individual ..
  8. Novel Assay for Ethylene Glycol Toxicity
    HANS KLOEPFER; Fiscal Year: 2002
    ..late or unnecessary treatment; 3) cutting intensive care and hospital stay; 4) abating long term morbidity (renal dialysis)...
  9. ZYNPEPTIDES AS MODULATORS OF RESPONSES TO BIOMATERIALS
    Gregory Kopia; Fiscal Year: 1991
    ..as in renal dialysis), or chronic, in-dwelling catheters...
  10. PATIENT ADHERENCE AND ADJUSTMENT IN RENAL DIALYSIS
    Alan Christensen; Fiscal Year: 1999
    DESCRIPTION: This is a FIRST award application for research on adherence and adjustment in renal dialysis patients. The research proposal has two phases...
  11. Dialysis Facility Management
    Eric Eisenstein; Fiscal Year: 2003
    ..ESRD patients typically survive fewer than five years after beginning renal dialysis. During this time they average 1.9 hospitalizations per year, for a total of 14 days...
  12. THERAPEUTIC APPLICATIONS OF MICROBUBBLES-PHASE II
    Thomas Porter; Fiscal Year: 2001
    ..to determine whether it can replace current pharmacologic and surgical techniques in recanalizing thrombosed renal dialysis grafts...
  13. Rapid patency assessment of dialysis vascular access
    Hansen Mansy; Fiscal Year: 2002
    Vascular access for renal dialysis is a lifeline for about 120,000 patients in the United States. Detection of access compromise is critical for optimal management...
  14. Noninvasive Raman Monitoring of Urea During Hemodialysis
    M Womble; Fiscal Year: 2004
    ..be produced rapidly, if the Phase II work is successful, by the adaptation for the clinical setting of the Company's present R-2001 Raman module for attachment by fiberoptic probe to existing renal dialysis equipment.
  15. Anastomotic Device for Large Vascular Grafts
    Hong Zhang; Fiscal Year: 2009
    ..These include ventricular assist device (VAD) implantation, arteriovenous (AV) fistula placement for renal dialysis, aortic arch reconstruction, and abdominal aortic aneurysm (AAA) repair...
  16. DIABETES AMONG THE MISSISSIPPI BAND OF CHOCTAW
    JAMES BINDON; Fiscal Year: 1991
    ..Nearly 50% of the diabetes are hypertensive, seven are on renal dialysis, and 11 patients had amputations during 1990...
  17. ROCHESTER CARIES RESEARCH CENTER
    William Bowen; Fiscal Year: 1993
    ..Marquis) Salivary Mediated Base Production in Humans (Dr. Tabak): Caries Experience in Renal Dialysis Patients (Dr. Meyerowitz): Effects of Age and Drug Induced Hyposalivation on Caries (Dr...
  18. MEDICAL DEVICE TO REMOVE ANTI-A AND ANTI-B ANTIBODIES
    TERRY SCHAACK; Fiscal Year: 2001
    DESCRIPTION: (Adapted from applicant's abstract) Renal transplant remains superior to chronic renal dialysis. Organ availability is the largest hurdle to transplant for thousands of individuals per year...
  19. NOVEL ASSAY METHODS FOR ETHYLENE GLYCOL TOXICITY
    HANS KLOEPFER; Fiscal Year: 1999
    ..screening, confirmatory and other testing; (2) averting late or unnecessary treatment; (3) cutting intensive care and hospital stay; (4) abating long-term morbidity (renal dialysis). PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
  20. Old Age, Life Extension, and Geriatrics
    SHARON KAUFMAN; Fiscal Year: 2005
    ..of life-extending medical procedures (cardiac bypass, angioplasty and stent; kidney and liver transplant; and renal dialysis) and how they each respond to those procedures; and second, to identify socio-cultural issues of relevance to ..
  21. SYNTHETIC RGD MATRIX TO SUPPORT ISLET TRANSPLANTATION
    MICHAEL PIERSCHBACHER; Fiscal Year: 1999
    ..Diabetes Mellitus, IDDM) occurs most often in children and young adults and accounts for one-third of renal dialysis patients. IDDM patients do not produce insulin and must take daily insulin to stay alive...
  22. "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"
    Allon Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  23. Antiproliferative Rx for venous neointimal hyperplasia
    Prabir Roy Chaudhury; Fiscal Year: 2005
    ..We believe that the results from this study could transform the clinical care of hemodialysis patients and at the same time result in the successful clinical application of local therapy for the treatment of neointimal hyperplasia...
  24. Effects of N-acetylcystein on Muscle Fatigue in ESRD
    KIRSTEN JOHANSEN; Fiscal Year: 2007
    ..To determine whether patients with ESRD generate excessive oxidative stress in response to exercise and whether muscle fatigue can be ameliorated by short-term treatment with N-acetylcysteine. [unreadable] [unreadable] [unreadable]..
  25. ANABOLIC STEROIDS AND EXERCISE IN HEMODIALYSIS
    KIRSTEN JOHANSEN; Fiscal Year: 2002
    ..abstract_text> ..
  26. World Workshop in Oral Medicine IV
    Peter Lockhart; Fiscal Year: 2005
    ..The proceedings will be published as evidence-based recommendations for best clinical practice in Oral Medicine as well as providing suggestions for future basic science and clinical research. ..
  27. Mechanisms Progression in Renal Insufficiency
    Timothy Meyer; Fiscal Year: 2006
    ..These studies, like those of endocytosis, will employ knockout mice to assess the importance of potential mediators of injury which are not yet subject to pharmacologic manipulation. ..
  28. Removal of Protein-Bound Solutes by Dialysis
    Timothy Meyer; Fiscal Year: 2007
    ..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..
  29. HEMODIALYSIS VASCULAR ACCESS CLINICAL TRIALS CONSORTIUM
    Michael Allon; Fiscal Year: 2007
    ..The primary endpoint will be fistula thrombosis within 6 weeks, and the secondary endpoint will be the ability to use the fistula successfully for dialysis within 6 months. ..
  30. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. New Evidence on the Persistence of High Health Spending
    Richard Hirth; Fiscal Year: 2009
    ..We will provide an example of how such estimates can inform the evaluation of risk-adjustment and reinsurance as mechanisms to improve the functioning of small group health insurance markets. ..
  32. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  33. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004
    ..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
  34. Donor Kidney Gene Expression and Delayed Graft Function
    Timothy Meyer; Fiscal Year: 2004
    ..Ultimately, better understanding of these mechanisms should provide a basis for treatment to prevent cadaver kidney injury and improve graft function. ..
  35. Vascular Access in Hemodialysis Patients
    Michael Allon; Fiscal Year: 2005
    ..The applicant will assist the trainees in acquiring the conceptual skills, research experience, and motivation required to pursue a successful career in Academic Nephrology. ..
  36. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
    ..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
  37. TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSIS
    Glenn Chertow; Fiscal Year: 2003
    ..The investigators have provided additional preliminary studies and have provided an extensive, detailed example of how the Monte Carlo models will be specified, validated, and optimized. ..
  38. Cognitive function in dialysis patients: Ancillary study to the FHN trial
    John B Stokes; Fiscal Year: 2010
    ..Knowing which impaired cognitive functions predict impaired driving skills will help develop strategies to improve cognition and thus enhance safe driving. Such strategies have the potential to make the highways safer for everyone. ..
  39. The Impact of Outcomes on Transplant Center Choice
    David Howard; Fiscal Year: 2004
    ..Using these estimates, we will simulate the impact of changes in survival rates on market shares for the groups of patients mentioned above. ..
  40. Current Antipsychotics and Fractures in Nursing Homes
    Sally Rigler; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  41. MethLock vs. heparin as dialysis catheter lock
    Stephen Ash; Fiscal Year: 2008
    ..In Phase II we will implement the protocol in a number of dialysis centers and complete the study as originally proposed or as modified after Phase I. ..
  42. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..abstract_text> ..
  43. Adiponectin and Cardiovascular Disease in the CKiD Children
    Mark Mitsnefes; Fiscal Year: 2009
    ....
  44. ADENOSINE AND RENAL INJURY
    MARK OKUSA; Fiscal Year: 2009
    ..These experiments also will shed light on the role of inflammation in the etiology of DN and provide insights into other potential anti-inflammatory therapeutic strategies. ..
  45. Novel Cardiovascular Risk Factors in Renal Insufficiency
    Sylvia Rosas; Fiscal Year: 2005
    ....
  46. PORPHYRIA AND HUMAN HEME BIOSYNTHESIS
    Robert J Desnick; Fiscal Year: 2010
    ..Viable CEP mice should permit studies of the disease pathophysiology and future therapeutic endeavors. ..
  47. Self Monitoring of Dietary and Fluid Intake Using a PDA
    Janet Welch; Fiscal Year: 2007
    ..Data from this study will be used in developing a large randomized controlled trial to evaluate the intervention's effectiveness. [unreadable] [unreadable]..
  48. Regulation of GnRH Neuronal Development by FGF Signaling
    John Gill; Fiscal Year: 2005
    ..Critical stages of GnRH neuron development will be evaluated in mice to discern the functional contribution of FGF signaling in this important neuroendocrine system. ..
  49. Outcomes of Prolonged Mechanical Ventilation
    Shannon Carson; Fiscal Year: 2006
    ..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
  50. Urban-Rural Sedative & Anxiolytic Use in Long Term Care
    Sally Rigler; Fiscal Year: 2005
    ....
  51. MALNUTRITION IN DIALYSIS PATIENTS
    TALAT IKIZLER; Fiscal Year: 2006
    ..abstract_text> ..
  52. Cardiac disease in children with chronic renal failure
    Mark Mitsnefes; Fiscal Year: 2006
    ..Thus, the long-term goal will be to decrease the incidence and prevalence of cardiovascular disease in young adults who developed chronic renal disease during childhood. ..
  53. Post Coronary Bypass Atrial Arrhythmic Prediction Rule
    Rod Passman; Fiscal Year: 2006
    ..This project will be an integral part of the candidate?s career development plan and his maturation as an epidemiologist, cardiac electrophysiologist, and clinical investigator. ..
  54. TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASIS
    Michael Whyte; Fiscal Year: 2002
    ....
  55. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..The safety systems of the existing PF system will be modified to meet the needs of the stand-alone system. Finally, an animal model of sepsis will be used to check efficacy and safety of the entire system. ..
  56. MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES
    ROBERT DESNICK; Fiscal Year: 2007
    ..It is anticipated that these trainees will continue the tradition of this program by becoming basic and/or clinical researchers in the field of human genetics and mental retardation. [unreadable] [unreadable]..
  57. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2007
    ..of increased intracranial pressure following trauma, the treatment of disequilibrium and hypotension during renal dialysis, the monitoring of hydration state of premature infants, and the investigation and diagnosis of orthostatic ..
  58. Urinary Biomarkers for Acute Kidney Injury in Critical Illness
    Steven Coca; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Infection, Persistence & Clearance of Oral HPV in Women
    Jimmy Efird; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  61. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  62. Renal Volume Measurement to Detect Early Kidney Disease
    W O NEILL; Fiscal Year: 2004
    ..abstract_text> ..