renal dialysis

Summary

Summary: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

Top Publications

  1. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
  2. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
  3. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
  4. doi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
  5. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
  6. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
  7. ncbi Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
  8. doi An improved comorbidity index for outcome analyses among dialysis patients
    Jiannong Liu
    United States Renal Data System Coordinating Center, 914 South 8th Street, Minneapolis, MN 55404, USA
    Kidney Int 77:141-51. 2010
  9. ncbi Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
  10. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001

Research Grants

  1. PROTAMINE FILTER FOR EXTRACORPOREAL HEPARIN REMOVAL
    Victor Yang; Fiscal Year: 1993
  2. ADHERENCE AND ADJUSTMENT IN END-STAGE RENAL DISEASE
    Alan Christensen; Fiscal Year: 2003
  3. Novel Assay for Ethylene Glycol Toxicity
    HANS KLOEPFER; Fiscal Year: 2002
  4. Dialysis Facility Management
    Eric Eisenstein; Fiscal Year: 2003
  5. FUNCTION OF PLATELETS AND COAGULATION FACTORS
    PHILIP MAJERUS; Fiscal Year: 1980
  6. Noninvasive Raman Monitoring of Urea During Hemodialysis
    M Womble; Fiscal Year: 2004
  7. Rapid assessment of vascular grafts patency
    Hansen Mansy; Fiscal Year: 2007
  8. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2007
  9. Old Age, Life Extension, and Geriatrics
    SHARON KAUFMAN; Fiscal Year: 2005
  10. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010

Detail Information

Publications305 found, 100 shown here

  1. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  2. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
    ....
  3. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
    ..Disorders of mineral metabolism are independently associated with mortality and morbidity associated with cardiovascular disease and fracture in hemodialysis patients...
  4. doi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
    ..Statins reduce the incidence of cardiovascular events in patients at high cardiovascular risk. However, a benefit of statins in such patients who are undergoing hemodialysis has not been proved...
  5. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
    ..Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established...
  6. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  7. ncbi Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
    ..Randomized clinical trials would permit definitive conclusions...
  8. doi An improved comorbidity index for outcome analyses among dialysis patients
    Jiannong Liu
    United States Renal Data System Coordinating Center, 914 South 8th Street, Minneapolis, MN 55404, USA
    Kidney Int 77:141-51. 2010
    ..Our index performance was almost identical to the individual comorbid conditions regarding model fit, predictive ability, and effect on inference, and it outperformed the widely used Charlson Comorbidity Index...
  9. ncbi Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
    ..Paricalcitol, a new vitamin D analogue, appears to lessen the elevations in serum calcium and phosphorus levels, as compared with calcitriol, the standard form of injectable vitamin D...
  10. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
    ..01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value...
  11. doi Association of Malnutrition-Inflammation Score with quality of life and mortality in hemodialysis patients: a 5-year prospective cohort study
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, CA, USA
    Am J Kidney Dis 53:298-309. 2009
    ..We hypothesized that MIS risk stratification of hemodialysis (HD) patients in predicting outcomes is better than its components or laboratory markers of inflammation...
  12. doi Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Francesca Tentori
    Arbor Research Collaborative for Health, University of Michigan, Ann Arbor, MI 48103, USA
    Am J Kidney Dis 52:519-30. 2008
    ....
  13. ncbi Cancer in patients on dialysis for end-stage renal disease: an international collaborative study
    P Maisonneuve
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Lancet 354:93-9. 1999
    ..The aim of this study was to examine the risk of cancer in a large cohort of patients treated by dialysis but not transplantation...
  14. ncbi Association of comorbid conditions and mortality in hemodialysis patients in Europe, Japan, and the United States: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    David A Goodkin
    Amgen Inc, Thousand Oaks, California, USA
    J Am Soc Nephrol 14:3270-7. 2003
    ..Adjustments for the observed variability will allow study of association between practice patterns and outcomes...
  15. ncbi Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:864-81. 2003
    ..Clinical trials focusing on MICS and its possible causes and consequences are urgently required to improve poor clinical outcome in dialysis patients...
  16. ncbi Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomes
    Dominique Joly
    Nephrology Unit, Necker Hospital and Université René Descartes Paris V, Paris, France
    J Am Soc Nephrol 14:1012-21. 2003
    ....
  17. doi Overview of regular dialysis treatment in Japan (as of 31 December 2008)
    Shigeru Nakai
    Renal Data Registry Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 14:505-40. 2010
    ..The risk of becoming HCV-positive was high in patients with low serum creatinine, serum albumin, and serum total cholesterol levels, and/or a low body mass index before beginning dialysis...
  18. ncbi Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 70:771-80. 2006
    ....
  19. ncbi Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002
    ..The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain...
  20. ncbi Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease
    Carmine Zoccali
    National Research Council Center of Clinical Physiology, Reggio Calabria, Italy
    J Am Soc Nephrol 13:134-41. 2002
    ..Furthermore, ADPN is related to several metabolic risk factors in a manner consistent with the hypothesis that this protein acts as a protective factor for the cardiovascular system...
  21. doi A randomized, controlled trial of early versus late initiation of dialysis
    Bruce A Cooper
    Department of Renal Medicine, Royal North Shore Hospital, Sydney Medical School, Sydney, Australia
    N Engl J Med 363:609-19. 2010
    ..In this study, conducted at 32 centers in Australia and New Zealand, we examined whether the timing of the initiation of maintenance dialysis influenced survival among patients with chronic kidney disease...
  22. doi Ankle brachial index as a predictor for mortality in patients with chronic kidney disease and undergoing haemodialysis
    Szu Chia Chen
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Nephrology (Carlton) 15:294-9. 2010
    ..The aim of this study was to investigate the predictors for mortality by using ABI value in patients with CKD and undergoing haemodialysis in Taiwan...
  23. doi Chronic dialysis and death among survivors of acute kidney injury requiring dialysis
    Ron Wald
    Division of Nephrology, St Michael s Hospital, 61 Queen St East, 9 140, Toronto, ON M5C 2T2, Canada
    JAMA 302:1179-85. 2009
    ..Severe acute kidney injury among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who survive to hospital discharge...
  24. ncbi Ankle-brachial blood pressure index predicts all-cause and cardiovascular mortality in hemodialysis patients
    Kumeo Ono
    Kan etsu Chuo Hospital, Maebashi, Gunma, Japan
    J Am Soc Nephrol 14:1591-8. 2003
    ..04 [1.14 to 8.12] for all-cause and cardiovascular mortality, respectively). Thus, the present findings validate ABPI as a powerful and independent predictor for all-cause and cardiovascular mortality among hemodialysis patients...
  25. pmc The associations of social support and other psychosocial factors with mortality and quality of life in the dialysis outcomes and practice patterns study
    Aurélie Untas
    Laboratoire de Psychologie Santé et Qualité de vie EA 4139, Universite de Bordeaux, Bordeaux, France
    Clin J Am Soc Nephrol 6:142-52. 2011
    ..This study aimed to investigate the influence of social support and other psychosocial factors on mortality, adherence to medical care recommendations, and physical quality of life among hemodialysis patients...
  26. doi Impact of the clinical conditions at dialysis initiation on mortality in incident haemodialysis patients: a national cohort study in Taiwan
    Shang Jyh Hwang
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nephrol Dial Transplant 25:2616-24. 2010
    ..We studied factors potentially related to the mortality in incident haemodialysis (HD) patients...
  27. doi Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Perit Dial Int 30:72-9. 2010
    ..Relative to hemoglobin A(1c) (HbA(1c)), percentage of glycated albumin (GA%) more accurately reflects recent glycemic control in diabetic hemodialysis (HD) patients...
  28. ncbi Serum beta-2 microglobulin levels predict mortality in dialysis patients: results of the HEMO study
    Alfred K Cheung
    VA Salt Lake City Healthcare System and Department of Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    J Am Soc Nephrol 17:546-55. 2006
    ..05 to 1.19; P = 0.001), after adjustment for residual kidney urea clearance and number of prestudy years on dialysis. This association is supportive of the potential value of beta(2)M as a marker to guide chronic hemodialysis therapy...
  29. doi Cardiovascular and noncardiovascular mortality among patients starting dialysis
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 104, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 302:1782-9. 2009
    ..Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population...
  30. ncbi A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center and the University of California Los Angeles, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 38:1251-63. 2001
    ..The MIS may be superior to the conventional SGA and the DMS, as well as to individual laboratory values, as a predictor of dialysis outcome and an indicator of MICS...
  31. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  32. pmc Biomarkers and health-related quality of life in end-stage renal disease: a systematic review
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 3:1759-68. 2008
    ....
  33. pmc Propensity-matched mortality comparison of incident hemodialysis and peritoneal dialysis patients
    Eric D Weinhandl
    Chronic Disease Research Group, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 21:499-506. 2010
    ..These data suggest that increased use of peritoneal dialysis may benefit incident ESRD patients...
  34. ncbi Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
    Kidney Int 63:793-808. 2003
    ..It is possible that new standards or goals for such traditional risk factors as body mass, serum cholesterol, and blood pressure should be considered for these individuals...
  35. ncbi Octogenarians and nonagenarians starting dialysis in the United States
    Manjula Kurella
    Division of Nephrology, University of California, San Francisco, CA 94118 1211, USA
    Ann Intern Med 146:177-83. 2007
    ....
  36. doi Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
    Geoffrey A Block
    Denver Nephrology Research Division, Denver, Colorado 80230, USA
    Kidney Int 78:578-89. 2010
    ..v. vitamin D. Definitive proof, however, of a survival advantage awaits the performance of randomized clinical trials...
  37. ncbi Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999
    Robert N Foley
    United States Renal Data System Coordinating Center, 914 South 8th Street, Suite D 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:489-95. 2005
    ..On an absolute basis, however, the high death rates of patients with CKD may reflect accelerated rates of atherosclerotic vascular disease and congestive heart failure...
  38. doi Clinical practices and outcomes in elderly hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Bernard Canaud
    Lapeyronie University Hospital, CHU Montpellier University, Montpellier, France
    Clin J Am Soc Nephrol 6:1651-62. 2011
    ..The Dialysis Outcomes and Practice Patterns Study (DOPPS) provides a unique opportunity to assess dialysis practices and associated outcomes among elderly versus younger patients on chronic in-center hemodialysis in 12 countries...
  39. doi Secular trends in cardiovascular mortality rates of patients receiving dialysis compared with the general population
    Matthew A Roberts
    Department of Nephrology, Austin Health, Melbourne, Australia
    Am J Kidney Dis 58:64-72. 2011
    ..We hypothesized that cardiovascular mortality rates in dialysis patients, which are higher than in the general population, have not decreased as much as those in the general population...
  40. ncbi Coronary artery calcification in patients with CRF not undergoing dialysis
    Domenico Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Am J Kidney Dis 44:1024-30. 2004
    ..Nearly all data about CAC relate to patients on dialysis therapy. This study evaluates the prevalence and extent of CAC in patients with chronic renal failure (CRF) not yet on dialysis therapy...
  41. pmc Nonrecovery of kidney function and death after acute on chronic renal failure
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 4:891-8. 2009
    ..Relatively little is known about clinical outcomes, especially long-term outcomes, among patients who have chronic kidney disease (CKD) and experience superimposed acute renal failure (ARF; acute on chronic renal failure)...
  42. pmc Current status of dialysis therapy in Korea
    Dong Chan Jin
    Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea
    Korean J Intern Med 26:123-31. 2011
    ..Mean Kt/V was 1.38 in male patients and 1.65 in female patients. Fifth, the overall 5-year survival rate of male patients undergoing dialysis was 65.4% and that of female patients was 67.4%...
  43. pmc Hemodialysis vascular access modifies the association between dialysis modality and survival
    Jeffrey Perl
    Division of Nephrology, St Michael s Hospital and The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Am Soc Nephrol 22:1113-21. 2011
    ..In conclusion, the use of CVCs in incident HD patients largely accounts for the early survival benefit seen with PD...
  44. doi Early start of dialysis: a critical review
    Steven Rosansky
    Dorn Research Institute, William Jennings Bryan Dorn Veterans Hospital, University of South Carolina, Arnold School of Public Health, Columbia, South Carolina 29206, USA
    Clin J Am Soc Nephrol 6:1222-8. 2011
    ..73 m(2), if accompanied by uremia symptoms or fluid management issues...
  45. ncbi Mortality risk among hemodialysis patients receiving different vitamin D analogs
    F Tentori
    Dialysis Clinic Inc, Albuquerque, New Mexico, USA
    Kidney Int 70:1858-65. 2006
    ..2 (1.1-1.3)). Mortality in doxercalciferol- and paricalcitol-treated patients was virtually identical. Differences in survival between vitamin D2 and D3 may be smaller than previously reported...
  46. pmc Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality
    Jennifer E Flythe
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 79:250-7. 2011
    ..Hence, higher ultrafiltration rates in hemodialysis patients are associated with a greater risk of all-cause and cardiovascular death...
  47. doi Inflammation in end-stage renal disease--what have we learned in 10 years?
    Juan J Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Semin Dial 23:498-509. 2010
    ..Causes and consequences of inflammation, genetic heritability of the inflammatory response, implications on outcome prognostication, and contemporary therapeutic evidence are some of the various topics discussed...
  48. doi Epidemiology, surveillance, and prevention of hepatitis C virus infections in hemodialysis patients
    Priti R Patel
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Atlanta, GA, USA
    Am J Kidney Dis 56:371-8. 2010
    ..This article describes the current epidemiology of HCV infection in US maintenance hemodialysis patients and prevention practices to decrease its incidence and transmission...
  49. doi Calcium, phosphorus, PTH and death rates in a large sample of dialysis patients from Latin America. The CORES Study
    Manuel Naves-Díaz
    Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Universidad de Oviedo, Julian Claveria s n, 33006 Oviedo, Spain
    Nephrol Dial Transplant 26:1938-47. 2011
    ..Mineral metabolism parameters may play a role in the survival of patients with chronic kidney disease (CKD)...
  50. ncbi Frequent Hemodialysis Network (FHN) randomized trials: study design
    R S Suri
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Kidney Int 71:349-59. 2007
    ....
  51. pmc Functional status of elderly adults before and after initiation of dialysis
    Manjula Kurella Tamura
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    N Engl J Med 361:1539-47. 2009
    ..It is unclear whether functional status before dialysis is maintained after the initiation of this therapy in elderly patients with end-stage renal disease (ESRD)...
  52. ncbi Effect of the ownership of dialysis facilities on patients' survival and referral for transplantation
    P P Garg
    Robert Wood Johnson Clinical Scholars Program, Department of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 341:1653-60. 1999
    ..Therefore, we examined the effect of for-profit ownership of dialysis facilities on patients' survival and referral for possible transplantation...
  53. ncbi The prevalence of symptoms in end-stage renal disease: a systematic review
    Fliss E M Murtagh
    Department of Palliative Care and Policy, Kings College London, London, UK
    Adv Chronic Kidney Dis 14:82-99. 2007
    ..The need for greater recognition of and research into symptom prevalence and causes, and interventions to alleviate them, is urgent...
  54. ncbi Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006
    ..4% in 1988 to 26.6% in 2002 (P < 0.001). This study provides evidence from an administrative database that the incidence of ARF and ARF-D is rising. Despite an increase in the degree of comorbidity, in-hospital mortality has declined...
  55. doi Travel time to dialysis as a predictor of health-related quality of life, adherence, and mortality: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Louise M Moist
    Division of Nephrology, London Health Sciences Center and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Am J Kidney Dis 51:641-50. 2008
    ..This study evaluated the effect of self-reported 1-way travel time to hemodialysis on mortality, health-related quality of life (HR-QOL), adherence, withdrawal from dialysis therapy, hospitalization, and transplantation...
  56. doi Early start of hemodialysis may be harmful
    Steven J Rosansky
    Dorn Research Institute, Wm Jennings Bryan Dorn Veterans Hospital, 526 N Trenholm Rd, Columbia, SC 29206, USA
    Arch Intern Med 171:396-403. 2011
    ..The current study examines a relatively "healthy" dialysis cohort to minimize confounding issues and determine whether early initiation of hemodialysis is associated with a survival benefit or harm...
  57. ncbi Mortality caused by sepsis in patients with end-stage renal disease compared with the general population
    M J Sarnak
    Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 58:1758-64. 2000
    ..Although it is intuitive to believe that mortality caused by sepsis may be higher in patients with ESRD compared with the general population (GP), no such data are currently available...
  58. ncbi Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
    J Zimmermann
    Department of Medicine, University Clinic Würzburg, Germany
    Kidney Int 55:648-58. 1999
    ..We hypothesize that several of the classic, as well as nontraditional, cardiovascular risk factors may respond to acute phase reactions. An activated acute phase response may influence or predict cardiovascular risk...
  59. doi Frequencies of hepatitis B and C infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: analysis of registry data
    David W Johnson
    Australia and New Zealand Dialysis and Transplant Registry, Discipline of Public Health, University of Adelaide, Adelaide, Australia
    Nephrol Dial Transplant 24:1598-603. 2009
    ..The aim of the present investigation was to evaluate the rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in peritoneal dialysis (PD) and haemodialysis (HD) patients in the Asia-Pacific region...
  60. doi Recombinant human erythropoietin treatment of chronic renal failure patients normalizes altered phenotype and proliferation of CD4-positive T lymphocytes
    Katarzyna A Lisowska
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Artif Organs 34:E77-84. 2010
    ..Our study confirms that rhEPO treatment normalizes activation parameters of CD4(+) T lymphocytes and their proliferative capacity, which could explain earlier described immunomodulatory effects of rhEPO in patients suffering from CRF...
  61. ncbi Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    J Am Soc Nephrol 16:2180-9. 2005
    ..Normalization of hemoglobin in incident hemodialysis patients does not have a beneficial effect on cardiac structure, compared with partial correction...
  62. ncbi Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Donna L Mapes
    Amgen, Inc, Thousand Oaks, California, USA
    Kidney Int 64:339-49. 2003
    ..We also compared HRQOL measures with serum albumin regarding their power to predict outcomes...
  63. doi Interferon-gamma release assays versus tuberculin skin testing for detection of latent tuberculosis in chronic haemodialysis patients
    Pierre Alain Triverio
    Division of Nephrology, Geneva University Hospital, 1211 Geneva 14, Switzerland
    Nephrol Dial Transplant 24:1952-6. 2009
    ..End stage renal disease increases the risk of reactivating latent tuberculosis (LTBI). Interferon-gamma release assays (IGRA) are an alternative to the tuberculin skin test (TST) for detecting LTBI...
  64. ncbi Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
    W N Suki
    Renal Section, Department of Medicine, The Kidney Institute, Baylor College of Medicine, Houston, Texas 77054, USA
    Kidney Int 72:1130-7. 2007
    ..There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings...
  65. doi Neutrophil gelatinase-associated lipocalin in dialyzed patients is related to residual renal function, type of renal replacement therapy and inflammation
    Jolanta Malyszko
    Department of Nephrology, Medical University, Bialystok, Poland
    Kidney Blood Press Res 32:464-9. 2009
    ..A cross-sectional study was performed to assess NGAL in serum, urine and ultrafiltrate in relation to the type of renal replacement therapy and NGAL correlations with renal function and markers of inflammation...
  66. ncbi The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer
    D Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Kidney Int 72:1255-61. 2007
    ..Our study shows that sevelamer treatment should not be restricted to dialysis patients; however, a larger study should be undertaken to confirm these results...
  67. doi Association of serum prealbumin and its changes over time with clinical outcomes and survival in patients receiving hemodialysis
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, General Clinical Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Clin Nutr 88:1485-94. 2008
    ..In patients receiving maintenance hemodialysis (MHD), a low serum prealbumin is an indicator of protein-energy wasting...
  68. ncbi Serum matrix metalloproteinases MMP-2 and MMP-3 levels in dialysis patients vary independently of CRP and IL-6 levels
    Gloria A Preston
    Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Nephron 92:817-23. 2002
    ..Little is known as to whether CRP, cytokines, such as IL-6 and IL-1beta that stimulate the synthesis of CRP, or matrix metalloproteinases (MMPs) are markers of inflammation in patients on dialysis...
  69. ncbi Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients
    K Sharma
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Kidney Int 51:1980-5. 1997
    ..In addition, plasma leptin is not cleared by hemodialysis with a modified cellulose membrane. Additional studies are required to evaluate the role of leptin in mediating the anorexia of uremia...
  70. ncbi Predictors of loss of residual renal function among new dialysis patients
    L M Moist
    Department of Medicine, University of Western Ontario, London, Canada
    J Am Soc Nephrol 11:556-64. 2000
    ..The observations of demographic groups at risk and potentially modifiable factors and therapies have generated testable hypotheses regarding therapies that may preserve RRF among end-stage renal disease patients...
  71. ncbi The quality of life and cost utility of home nocturnal and conventional in-center hemodialysis
    Philip A McFarlane
    Department of Medicine, Home Dialysis Clinic, Inner City Health Research Unit, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 64:1004-11. 2003
    ..We hypothesized that individuals performing home nocturnal hemodialysis would have a higher quality of life and superior cost utility than in-center hemodialysis patients...
  72. ncbi Lipoprotein metabolism and lipid management in chronic kidney disease
    Bonnie C H Kwan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Am Soc Nephrol 18:1246-61. 2007
  73. pmc Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
    ..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
  74. doi The impact of dialysis modality on serum heat shock proteins in children and young adults with chronic kidney disease
    Kinga Musiał
    Department of Pediatric Nephrology, Wrocław Medical University, Wrocław, Poland
    Kidney Blood Press Res 32:366-72. 2009
    ..The aim of the study was to evaluate the serum HSP, their connections with dialysis modality and their possible role as markers of atherosclerosis...
  75. doi Glycemic control and cardiovascular events in diabetic hemodialysis patients
    Christiane Drechsler
    Department of Medicine, Division of Nephrology, University Hospital, Oberdürrbacherstrasse 6, D 97080 Wurzburg, Germany
    Circulation 120:2421-8. 2009
    ..Poor glycemic control is associated with cardiovascular comorbidities in the general population. This study investigated the impact of glycemic control on cardiac and vascular outcomes in diabetic hemodialysis patients...
  76. doi Impact of haemoglobin and erythropoietin dose changes on mortality: a secondary analysis of results from a randomized anaemia management trial
    Joanne H Lau
    Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Canada
    Nephrol Dial Transplant 25:4002-9. 2010
    ..To date, no study has evaluated the impact of Hgb variability on mortality in the setting of a uniform Hgb target and erythropoiesis-stimulating agents (ESA) dosing strategy...
  77. doi Sex-specific association of time-varying haemoglobin values with mortality in incident dialysis patients
    Gisela Sturm
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstr 41, Innsbruck, Austria
    Nephrol Dial Transplant 25:2715-22. 2010
    ..Previous studies in dialysis patients showed an association between haemoglobin levels and all-cause mortality, however, without addressing sex differences...
  78. pmc The views of patients and carers in treatment decision making for chronic kidney disease: systematic review and thematic synthesis of qualitative studies
    R L Morton
    Sydney School of Public Health, University of Sydney, Sydney, NSW 2006, Australia
    BMJ 340:c112. 2010
    ..To synthesise the views of patients and carers in decision making regarding treatment for chronic kidney disease, and to determine which factors influence those decisions...
  79. ncbi Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition
    Yongmei Liu
    Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 291:451-9. 2004
    ..This paradox may be explained by systemic inflammation and/or malnutrition, which are associated with lower cholesterol levels and higher mortality...
  80. doi The HSP72 stress response of monocytes from patients on haemodialysis is impaired
    Stefan Reuter
    Department of Medicine D, University of Munster, Germany
    Nephrol Dial Transplant 24:2838-46. 2009
    ..Renal insufficiency-related alteration of microbicidal and tumoricidal functions of Mphi, major effectors of the immune system, might promote these diseases...
  81. ncbi The kind of vascular access influences the baseline inflammatory status and epoetin response in chronic hemodialysis patients
    Ezio Movilli
    Chair and Division of Nephrology, Spedali Civili and University of Brescia, University of Brescia, Brescia, Italy
    Blood Purif 24:387-93. 2006
    ....
  82. ncbi Impact of kidney bone disease and its management on survival of patients on dialysis
    Grace H Lee
    Department of Pharmacy, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Ren Nutr 17:38-44. 2007
    ..Because these associations may be secondary to bias by indication, randomized clinical trials are necessary to verify the findings of this and similar observational studies...
  83. ncbi Hemodialysis clinical practice guidelines for the Canadian Society of Nephrology
    Kailash Jindal
    J Am Soc Nephrol 17:S1-27. 2006
  84. ncbi Predialysis psychoeducational intervention extends survival in CKD: a 20-year follow-up
    Gerald M Devins
    Behavioral Sciences and Health Research Division, Toronto General Research Institute, Toronto, Canada
    Am J Kidney Dis 46:1088-98. 2005
    ..The present research examines long-term survival after predialysis psychoeducational intervention. In addition, we examined whether survival differed because of early (ie, > or = 3 months) versus late referral to nephrology...
  85. ncbi Assessment and clinical aspects of health-related quality of life in dialysis patients and patients with chronic kidney disease
    Stig Molsted
    Department of Nephrology, Hilleroed Hospital, Hilleroed, Denmark
    Nephron Clin Pract 106:c24-33. 2007
    ....
  86. ncbi A systematic review of the effect of nocturnal hemodialysis on blood pressure, left ventricular hypertrophy, anemia, mineral metabolism, and health-related quality of life
    Michael Walsh
    Department of Medicine, University of Calgary, Alberta, Canada
    Kidney Int 67:1500-8. 2005
    ..A systematic review of the current available literature was undertaken to examine the effect of nocturnal hemodialysis on key health outcomes...
  87. ncbi Plasma aluminium: a redundant test for patients on dialysis?
    P M Gault
    Department of Clinical Biochemistry, Leeds Teaching Hospitals, Britannia House, Morley, Leeds LS27 0DQ, UK
    Ann Clin Biochem 42:51-4. 2005
    Aluminium toxicity as a cause of dementia, osteodystrophy and anaemia in patients receiving renal dialysis was first described in the 1970s and led to the regular monitoring of aluminium in plasma and dialysate water...
  88. ncbi Uremic malnutrition is a predictor of death independent of inflammatory status
    Lara B Pupim
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    Kidney Int 66:2054-60. 2004
    ..Often, these conditions coexist, and the relative importance of poor nutritional status and chronic inflammation in terms of predicting clinical outcomes in chronic hemodialysis (CHD) patients has not been clarified...
  89. ncbi Knowledge of dietary restrictions and the medical consequences of noncompliance by patients on hemodialysis are not predictive of dietary compliance
    Claire Louise Durose
    FOAD Centre, University of Southampton, School of Medicine, Princess Anne Hospital, United Kingdom
    J Am Diet Assoc 104:35-41. 2004
    ..To investigate whether knowledge of the diet and medical consequences of noncompliance influences dietary compliance among patients on hemodialysis...
  90. ncbi Long-term dialysis survivors: a transformational experience
    Roberta Braun Curtin
    Medical Education Institute, Inc, Madison, WI, USA
    Qual Health Res 12:609-24. 2002
    ....
  91. ncbi Mortality among hemodialysis patients in Europe, Japan, and the United States: case-mix effects
    David A Goodkin
    University Renal Research and Education Association, Ann Arbor, MI 48103, USA
    Am J Kidney Dis 44:16-21. 2004
    ....
  92. doi Comparison of glycated albumin and hemoglobin A(1c) levels in diabetic subjects on hemodialysis
    T P Peacock
    Section of Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 73:1062-8. 2008
    ..Our results show that in diabetic hemodialysis patients, hemoglobin A(1c) levels significantly underestimate glycemic control while those of glycated albumin more accurately reflect this control...
  93. ncbi Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients
    Manchang Liu
    Division of Clinical Immunology, Department of Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nephrol Dial Transplant 18:563-9. 2003
    ..Lack of nocturnal blood pressure (BP) fall (non-dipping) is common among haemodialysis (HD) patients, but much less is known regarding its association with cardiovascular (CV) disease morbidity and mortality...
  94. pmc Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD
    Gerard M London
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, France
    J Am Soc Nephrol 19:1827-35. 2008
    ..Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls...
  95. ncbi Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients
    Kirsten L Johansen
    Division of Nephrology, San Francisco Veterans Affairs Medical Center, CA 94121, USA
    Am J Clin Nutr 77:842-6. 2003
    ..Cross-sectional studies have shown an association between the duration (y) of dialysis and nutritional status, providing evidence of wasting...
  96. ncbi Calcium, phosphate, and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality: evidence for the complexity of the association between mineral metabolism and outcomes
    Lesley A Stevens
    Division of Nephrology, New England Medical Centre, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:770-9. 2004
    ..In so doing, the complex interaction of time and MM can begin to be understand. Further exploration is required...
  97. pmc A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients
    Steven C Cheng
    Division of Nephrology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8129, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 3:1131-8. 2008
    ..A prospective, randomized, double-blind, placebo-controlled crossover trial was performed for assessment of the safety and efficacy of niacinamide...
  98. ncbi Optimization of dialysate sodium in sodium profiling haemodialysis
    Moon Jae Kim
    Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Inchon City, Korea
    Nephrology (Carlton) 8:S16-22. 2003
    ..In the future, dialysate sodium should be optimized based on the exact prediction of the postdialysis plasma sodium levels...
  99. ncbi Optimization of epoetin therapy with intravenous iron therapy in hemodialysis patients
    A Besarab
    Department of Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    J Am Soc Nephrol 11:530-8. 2000
    ..Reticulocyte hemoglobin content increased only in the study group from 28.5 to 30.1 pg. It is concluded that maintenance of TSAT between 30 and 50% reduces rhEPO requirements significantly over a 6-mo period...
  100. ncbi The low molecular weight apo(a) phenotype is an independent predictor for coronary artery disease in hemodialysis patients: a prospective follow-up
    F Kronenberg
    Institute of Medical Biology and Human Genetics, University of Innsbruck, Austria
    J Am Soc Nephrol 10:1027-36. 1999
    ..Apo(a) phenotyping might be helpful to identify hemodialysis patients at high risk for coronary artery disease...
  101. ncbi Mortality and technique failure in patients starting chronic peritoneal dialysis: results of The Netherlands Cooperative Study on the Adequacy of Dialysis. NECOSAD Study Group
    K J Jager
    Department of Nephrology, Academic Medical Center, University of Amsterdam, The Netherlands
    Kidney Int 55:1476-85. 1999
    ..The aim of this study was to determine the relative importance of baseline patient and treatment characteristics to mortality and technique failure in patients starting peritoneal dialysis...

Research Grants99

  1. PROTAMINE FILTER FOR EXTRACORPOREAL HEPARIN REMOVAL
    Victor Yang; Fiscal Year: 1993
    Extracorporeal blood circulation (ECBC) has been employed in many important clinical situations such as renal dialysis and cardiopulmonary bypass. In the US alone, more than 15 million ECBC procedures are performed each year...
  2. ADHERENCE AND ADJUSTMENT IN END-STAGE RENAL DISEASE
    Alan Christensen; Fiscal Year: 2003
    ..characteristics that influence medical regimen adherence and emotional adjustment among patients treated with renal dialysis. This will be accomplished using a longitudinal study design that considers the effects of patient individual ..
  3. Novel Assay for Ethylene Glycol Toxicity
    HANS KLOEPFER; Fiscal Year: 2002
    ..late or unnecessary treatment; 3) cutting intensive care and hospital stay; 4) abating long term morbidity (renal dialysis)...
  4. Dialysis Facility Management
    Eric Eisenstein; Fiscal Year: 2003
    ..ESRD patients typically survive fewer than five years after beginning renal dialysis. During this time they average 1.9 hospitalizations per year, for a total of 14 days...
  5. FUNCTION OF PLATELETS AND COAGULATION FACTORS
    PHILIP MAJERUS; Fiscal Year: 1980
    ..We are also carrying out a randomized double bind study to determine the efficacy of 180mg aspirin per day in preventing shunt thrombosis in patients with chronic renal dialysis.
  6. Noninvasive Raman Monitoring of Urea During Hemodialysis
    M Womble; Fiscal Year: 2004
    ..be produced rapidly, if the Phase II work is successful, by the adaptation for the clinical setting of the Company's present R-2001 Raman module for attachment by fiberoptic probe to existing renal dialysis equipment.
  7. Rapid assessment of vascular grafts patency
    Hansen Mansy; Fiscal Year: 2007
    ..The Phase I effort focused on renal dialysis access grafts and fistulas, and showed high accuracy (p <...
  8. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2007
    ..of increased intracranial pressure following trauma, the treatment of disequilibrium and hypotension during renal dialysis, the monitoring of hydration state of premature infants, and the investigation and diagnosis of orthostatic ..
  9. Old Age, Life Extension, and Geriatrics
    SHARON KAUFMAN; Fiscal Year: 2005
    ..of life-extending medical procedures (cardiac bypass, angioplasty and stent; kidney and liver transplant; and renal dialysis) and how they each respond to those procedures; and second, to identify socio-cultural issues of relevance to ..
  10. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  11. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  12. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  13. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2009
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  14. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2009
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  15. Examining Racial and Cardiovascular Paradoxes in Chronic Kidney Disease
    Kamyar Kalantar Zadeh; Fiscal Year: 2010
    ..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
  16. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2007
    ....
  17. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  18. The role of hypoxia in venous neointimal hyperplasia in hemodialysis grafts
    Sanjay Misra; Fiscal Year: 2010
    ..The long term goal of this current proposal and research program is to improve the care of patients with ESRD, the vast majority of who use long-term hemodialysis as their mode of renal replacement therapy. ..
  19. Predictors of Hemodialysis Access Dysfunction
    Haimanot Wasse; Fiscal Year: 2007
    ..The proposed studies aim to elucidate reasons for the disparities in vascular access survival among diabetics and AA's. ..
  20. Antiproliferative Rx for venous neointimal hyperplasia
    Prabir Roy Chaudhury; Fiscal Year: 2005
    ..We believe that the results from this study could transform the clinical care of hemodialysis patients and at the same time result in the successful clinical application of local therapy for the treatment of neointimal hyperplasia...
  21. HEMODIALYSIS VASCULAR ACCESS CLINICAL TRIALS CONSORTIUM
    Michael Allon; Fiscal Year: 2007
    ..The primary endpoint will be fistula thrombosis within 6 weeks, and the secondary endpoint will be the ability to use the fistula successfully for dialysis within 6 months. ..
  22. TRAINING IN KIDNEY DISEASE, HYPERTENSION, CELL BIOLOGY
    John Stokes; Fiscal Year: 2007
    ..At Iowa, research training is an important component of our overall mission. A strong faculty, strong institutional resources, and a strong applicant pool are the hallmarks of this application. ..
  23. Cognitive Behavioral Treatment of Depression in ESRD PAtients on Dialysis
    Daniel Cukor; Fiscal Year: 2007
    ..If it is proven to be beneficial, this targeted and brief intervention could be incorporated into standard of care for all depressed dialysis patients. ..
  24. Are Cardioprotective Medications Effective in ESRD?
    Theresa I Shireman; Fiscal Year: 2010
    ..This project will evaluate the effectiveness of cardioprotective medications in reducing cardiac deaths and hospitalizations in ESRD patients. ..
  25. Genetic Analysis of African American Hypertensive End-Stage Renal Disease
    Barry Freedman; Fiscal Year: 2009
    ....
  26. Natural History of MYH9-Associated Nephropathy
    Barry Freedman; Fiscal Year: 2009
    ..This will benefit individuals at risk who could benefit from therapeutic intervention to alleviate disease at an earlier stage. The anticipated benefits to the population at large outweigh the minimal risk involved in the study. ..
  27. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  28. Pyrophosphate in vascular calcification of renal failure
    W O NEILL; Fiscal Year: 2007
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  29. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2004
    ..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
  30. Renal Volume Measurement to Detect Early Kidney Disease
    W O NEILL; Fiscal Year: 2004
    ..abstract_text> ..
  31. PREVENTION OF HEMODIALYSIS VASCULAR ACCESS STENOSIS
    Alfred Cheung; Fiscal Year: 2007
    ..It is highly likely that, within this 5-year proposal, the results of this project can be applied to pilot clinical studies. ..
  32. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    Peter Heeger; Fiscal Year: 2007
    ..The findings derived from the work will define the role for indirectly primed CD8 T cells in allograft rejection and have the potential to guide future therapies aimed a prolonging graft survival. ..
  33. Novel Biomarkers in Cardiac Surgery to Detect Acute Kidney Injury
    Chirag Parikh; Fiscal Year: 2009
    ..The ultimate findings of this study will pave the way for larger multi-center studies of these biomarkers in other clinical conditions and for interventional clinical trials to prevent or to treat AKI. ..