kidney transplantation


Summary: The transference of a kidney from one human or animal to another.

Top Publications

  1. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
  2. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
  3. ncbi Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
  4. ncbi Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    C Wiebe
    Department of Medicine and Immunology, University of Manitoba, Canada
    Am J Transplant 12:1157-67. 2012
  5. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
  6. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
  7. ncbi Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes
    M Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 11:2093-109. 2011
  8. ncbi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
  9. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
  10. pmc IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation
    Isaac E Hall
    Department of Medicine, Yale University, West Haven, CT 06516, USA
    J Am Soc Nephrol 21:189-97. 2010

Detail Information

Publications362 found, 100 shown here

  1. ncbi Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant
    R A Wolfe
    U S Renal Data System Coordinating Center, Department of Biostatistics, University of Michigan, Ann Arbor 48103, USA
    N Engl J Med 341:1725-30. 1999
  2. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
    ..The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known...
  3. ncbi Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
    ..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
  4. ncbi Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    C Wiebe
    Department of Medicine and Immunology, University of Manitoba, Canada
    Am J Transplant 12:1157-67. 2012
  5. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
    ..S. and how this has impacted graft survival in the most recent era of kidney transplantation. For this purpose, we analyzed data provided by the Scientific Registry of Transplant Recipients regarding ..
  6. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
    ..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
  7. ncbi Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes
    M Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 11:2093-109. 2011
    Individual studies indicate that kidney transplantation is associated with lower mortality and improved quality of life compared with chronic dialysis treatment...
  8. ncbi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
  9. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
    ..This prospective cohort indicates that many actual failures after indication biopsies manifest phenotypic features of antibody-mediated or mixed rejection and also underscores the major role of nonadherence...
  10. pmc IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation
    Isaac E Hall
    Department of Medicine, Yale University, West Haven, CT 06516, USA
    J Am Soc Nephrol 21:189-97. 2010
    Current methods for predicting graft recovery after kidney transplantation are not reliable...
  11. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    ..With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure...
  12. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
    ..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
  13. pmc Delayed graft function in the kidney transplant
    A Siedlecki
    Nephrology Division, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO, USA
    Am J Transplant 11:2279-96. 2011
    Acute kidney injury occurs with kidney transplantation and too frequently progresses to the clinical diagnosis of delayed graft function (DGF)...
  14. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
  15. ncbi Diabetes mellitus after kidney transplantation in the United States
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, MN, USA
    Am J Transplant 3:178-85. 2003
    New onset diabetes is a major complication after kidney transplantation. However, the incidence, risk factors and clinical relevance of post-transplant diabetes mellitus (PTDM) vary among reports from single-center observational studies ..
  16. ncbi Everolimus-based, calcineurin-inhibitor-free regimen in recipients of de-novo kidney transplants: an open-label, randomised, controlled trial
    Klemens Budde
    Department of Nephrology, Charite University, Berlin, Germany
    Lancet 377:837-47. 2011
    ..allow reduction of calcineurin-inhibitor exposure without compromising safety or efficacy remain a goal in kidney transplantation. Immunosuppression based on the mammalian-target-of-rapamycin inhibitor everolimus was assessed as a ..
  17. ncbi Delayed graft function in kidney transplantation
    Norberto Perico
    Department of Medicine and Transplantation, Ospedali Riuniti di Bergamo Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Lancet 364:1814-27. 2004
  18. pmc Identification of a B cell signature associated with renal transplant tolerance in humans
    Kenneth A Newell
    Emory University, Atlanta, Georgia, USA
    J Clin Invest 120:1836-47. 2010
    ..These results point to a critical role for B cells in regulating alloimmunity and provide a candidate set of genes for wider-scale screening of renal transplant recipients...
  19. ncbi Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation
    C R Parikh
    Nephrology, Yale University, New Haven, Connecticut, USA
    Am J Transplant 6:1639-45. 2006
    ..01). Our results indicate that urine NGAL and IL-18 represent early, predictive biomarkers of DGF...
  20. ncbi Immunosuppressive drugs for kidney transplantation
    Philip F Halloran
    Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    N Engl J Med 351:2715-29. 2004
  21. ncbi Long-term renal allograft survival in the United States: a critical reappraisal
    K E Lamb
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Am J Transplant 11:450-62. 2011
  22. ncbi Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression
    B W Pinsky
    Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO, USA
    Am J Transplant 9:2597-606. 2009
    We describe factors associated with immunosuppression compliance after kidney transplantation and examine relationships between compliance with allograft outcomes and costs...
  23. ncbi Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial
    Francesco P Schena
    Renal, Dialysis and Transplant Unit, Department of Emergency and Organ Transplant, University of Bari, Bari, Italy
    Transplantation 87:233-42. 2009
    ..The efficacy and safety of converting maintenance renal transplant recipients from calcineurin inhibitors (CNIs) to sirolimus (SRL) was evaluated...
  24. ncbi Incidence and impact of de novo donor-specific alloantibody in primary renal allografts
    Matthew J Everly
    Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
    Transplantation 95:410-7. 2013
    ..This report details the dnDSA incidence and actual 3-year post-dnDSA graft outcomes...
  25. ncbi Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis
    Sri G Yarlagadda
    Section of Nephrology, University of Kansas Medical Center, Kansas City, KS, USA
    Nephrol Dial Transplant 24:1039-47. 2009
    ..We conducted a systematic review and meta-analysis to precisely estimate these relationships...
  26. ncbi Antibody-mediated renal allograft rejection: diagnosis and pathogenesis
    Robert B Colvin
    Pathology Department, Thier 831, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Soc Nephrol 18:1046-56. 2007
    ..Clinical trials will be needed to ascertain the optimal treatment for the newly appreciated conditions chronic humoral rejection and accommodation...
  27. ncbi Which is the most suitable and effective route of administration for mesenchymal stem cell-based immunomodulation therapy in experimental kidney transplantation: endovenous or arterial?
    S Zonta
    Dipartimento di Scienze, Chirurgia Epatopancreatica, IRCCS Pol San Matteo, Chirurgiche Università di Pavia, Italy
    Transplant Proc 42:1336-40. 2010
    ..vs intravenous) was the most effective route to achieve immunomodulating effects in experimental rat kidney transplantation. Transgenic Sprague-Dawley rats (SD) expressing the enhanced green fluorescent protein (EGFP) at the ..
  28. pmc The APOL1 gene and allograft survival after kidney transplantation
    A M Reeves-Daniel
    Department of Internal Medicine, Section on Nephrology, Winston Salem, North Carolina, USA
    Am J Transplant 11:1025-30. 2011
    ..If replicated, APOL1 genotyping could improve the donor selection process and maximize long-term renal allograft survival...
  29. ncbi A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    A Durrbach
    Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
    Am J Transplant 10:547-57. 2010
  30. ncbi The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient death
    Herwig Ulf Meier-Kriesche
    Division of Nephrology, University of Florida, Shands Hospital, 1600 SW Archer Rd, Rm CG 98, Gainesville FL 32610 0224, USA
    Transplantation 73:70-4. 2002
    ..To investigate this hypothesis we retrospectively analyzed 51,927 primary, adult renal transplants registered in the USRDS...
  31. ncbi Tacrolimus once daily (ADVAGRAF) versus twice daily (PROGRAF) in de novo renal transplantation: a randomized phase III study
    B K Krämer
    V Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Transplant 10:2632-43. 2010
    ..Overall results obtained with either Tacrolimus QD or BID, without antibody induction, were good, supporting use of the once-daily formulation as an effective alternative to the established twice-daily formulation...
  32. pmc Sirolimus is associated with new-onset diabetes in kidney transplant recipients
    Olwyn Johnston
    Division of Nephrology, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    J Am Soc Nephrol 19:1411-8. 2008
    ..Given the negative impact of NOD on posttransplantation outcomes, these findings should be confirmed in prospective studies or in meta-analyses of existing trials that involved sirolimus...
  33. pmc Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
    Pervinder Sagoo
    MRC Centre for Transplantation, King s College London, London, United Kingdom
    J Clin Invest 120:1848-61. 2010
    ..This study provides an immunological profile of the tolerant state that, with further validation, should inform and shape drug-weaning protocols in renal transplant recipients...
  34. pmc Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility
    Norberto Perico
    Transplant Research Center Chiara Cucchi de Alessandri e Gilberto Crespi, Department of Immunology and Transplantation, Ospedali Riuniti di Bergamo, Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Parco Scientifico Tecnologico Kilometro Rosso, via Stezzano 87, 24126 Bergamo, Italy
    Clin J Am Soc Nephrol 6:412-22. 2011
    ..Mesenchymal stromal cells (MSCs) abrogate alloimmune response in vitro, suggesting a novel cell-based approach in transplantation. Moving this concept toward clinical application in organ transplantation should be critically assessed...
  35. ncbi Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 10:464-71. 2010
  36. ncbi Treatment for BK virus: incidence, risk factors and outcomes for kidney transplant recipients in the United States
    Jesse D Schold
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Transpl Int 22:626-34. 2009
    ..Careful monitoring and further understanding of disease etiology and treatment strategies are needed...
  37. ncbi Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    K Solez
    University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:518-26. 2007
    ..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
  38. ncbi Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection
    Roberto Marcen
    Department of Nephrology, Ramon y Cajal Hospital, Alcala de Henares University, Madrid, Spain
    Drugs 69:2227-43. 2009
    ..Preliminary results with belatacept suggest its safety and efficacy, and open new perspectives in the immunosuppression of de novo renal transplant recipients...
  39. ncbi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  40. ncbi Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection
    Lorraine C Racusen
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 3:708-14. 2003
    ..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
  41. ncbi Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention
    M Kosieradzki
    Department of General and Transplantation Surgery, Transplantation Institute, Medical University of Warsaw, Poland
    Transplant Proc 40:3279-88. 2008
    Ischemia has been an inevitable event accompanying kidney transplantation. Ischemic changes start with brain death, which is associated with severe hemodynamic disturbances: increasing intracranial pressure results in bradycardia and ..
  42. pmc Long-term consequences of kidney donation
    Hassan N Ibrahim
    Department of Medicine, University of Minnesota, Minneapolis 55414, USA
    N Engl J Med 360:459-69. 2009
    ..Previous studies have included relatively small numbers of donors and a brief follow-up period...
  43. ncbi Cancer incidence before and after kidney transplantation
    Claire M Vajdic
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    JAMA 296:2823-31. 2006
    ..Although it is generally accepted that other cancers do not occur at increased rates, there have been few long-term population-based cohort studies performed...
  44. ncbi Long-term survival in renal transplant recipients with graft function
    A O Ojo
    Departments of Medicine, The University of Michigan, Ann Arbor, Michigan 48109 0364, USA
    Kidney Int 57:307-13. 2000
    ..Long-term survival in renal transplant recipients with graft function...
  45. ncbi Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining
    Banu Sis
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 9:2312-23. 2009
    ..94%) than C4d. The results were validated in independent set of 82 kidneys. High renal endothelial transcript expression in patients with alloantibody is indicator of active antibody-mediated allograft damage and poor graft outcome...
  46. ncbi Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients
    Hans H Hirsch
    Division of Infectious Diseases, University of Basel, Basel, Switzerland
    N Engl J Med 347:488-96. 2002
  47. ncbi Management of polyomavirus-associated nephropathy in renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Nephrol 8:390-402. 2012
    ..Finally, novel compounds and their in vitro actions against BKV are discussed together with future prospects for specific antiviral drug development...
  48. ncbi Vaccine-induced allo-HLA-reactive memory T cells in a kidney transplantation candidate
    Lloyd J A D'Orsogna
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Transplantation 91:645-51. 2011
    ..However, the effect of successful vaccination on the alloreactive memory T-cell repertoire is unclear. We hypothesized that vaccination could specifically induce allo-HLA-reactive memory T cells...
  49. ncbi Non-adherence to immunosuppressive medications in kidney transplantation: intent vs. forgetfulness and clinical markers of medication intake
    Konstadina Griva
    Department of Psychology, National University of Singapore, 9 Arts Link AS402 28, Singapore, Singapore
    Ann Behav Med 44:85-93. 2012
    ..The purpose of this study was to examine intentional and unintentional non-adherence to immunosuppression medication in kidney transplant patients...
  50. ncbi The cost-effectiveness of increasing kidney transplantation and home-based dialysis
    Kirsten Howard
    University of Sydney, Australia
    Nephrology (Carlton) 14:123-32. 2009
    ..We aimed to quantify these implications for increasing kidney transplantation and improving the rate of home-based dialysis.
  51. ncbi Posttransplantation encapsulating peritoneal sclerosis contributes significantly to mortality after kidney transplantation
    M R Korte
    Albert Schweitzer Hospital, Department of Internal Medicine, Dordrecht, The Netherlands
    Am J Transplant 11:599-605. 2011
    ..peritoneal sclerosis (EPS) is a severe complication of peritoneal dialysis (PD) and may present after kidney transplantation, a condition known as posttransplantation EPS...
  52. ncbi Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease--a cross-sectional study of predialysis, dialysis and kidney-transplantation patients
    Alejandro Recio-Mayoral
    Division of Cardiac and Vascular Sciences, St Georges Hospital and St Georges, University of London, UK
    Atherosclerosis 216:446-51. 2011
    ..We assessed the relationship among, endothelial dysfunction, early atherosclerosis and inflammation in predialysis, dialysis and post kidney-transplantation CKD patients...
  53. pmc Early basal insulin therapy decreases new-onset diabetes after renal transplantation
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:739-49. 2012
    ..In conclusion, this study suggests regimens that include basal insulin significantly reduce the odds for NODAT after renal transplantation, presumably via insulin-mediated protection of β cells...
  54. ncbi Polyomavirus BK
    Hans H Hirsch
    Division of Infectious Diseases, Department of Internal Medicine, University Hospitals Basel, and Transplantation Virology Laboratory, Institute of Medical Microbiology, University of Basel, Switzerland
    Lancet Infect Dis 3:611-23. 2003
    ..Case series suggest that cidofovir might be effective, especially when combined with reduced immunosuppression...
  55. pmc Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conference
    Michael Abecassis
    Division of Nephrology, University of Alabama at Birmingham, 625 THT, 1900 University Boulevard, Birmingham, AL 35294, USA
    Clin J Am Soc Nephrol 3:471-80. 2008
    b>Kidney transplantation is the most desired and cost-effective modality of renal replacement therapy for patients with irreversible chronic kidney failure (end-stage renal disease, stage 5 chronic kidney disease)...
  56. ncbi A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 12:1168-79. 2012
    ..Thus any degree of microcirculation inflammation in late kidney transplant biopsies strongly indicates presence of DSA and predicts progression to graft failure...
  57. pmc Fibrogenesis in kidney transplantation: potential targets for prevention and therapy
    Arjang Djamali
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53793, USA
    Transplantation 88:1149-56. 2009
    ..Clinical trials are needed to examine the effect of these therapies on long-term outcomes...
  58. ncbi Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation
    Sebastian Riethmüller
    Division of Visceral and Transplant Surgery, University Hospital, Zurich, Switzerland
    Transplantation 90:160-7. 2010
    ..This study evaluated the prognostic impact of pretransplant donor-specific anti-human leukocyte antigen antibodies (DSA) detected by single-antigen beads and compared the three generations of crossmatch (XM) tests in kidney transplantation.
  59. ncbi Posttransplant de novo donor-specific hla antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection
    F Ginevri
    Pediatric Nephrology, Istituto G Gaslini, Genova, Italy
    Am J Transplant 12:3355-62. 2012
    ..005). In our pediatric cohort, DSA identify patients at risk of renal dysfunction, AMR and graft loss; treatment started at Ab emergence might prevent AMR occurrence and/or progression to graft failure...
  60. ncbi Impact of HLA mismatching on incidence of posttransplant non-hodgkin lymphoma after kidney transplantation
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 61920 Heidelberg, Germany
    Transplantation 89:567-72. 2010
    ..Posttransplant non-Hodgkin lymphoma is a rare complication but associated with high mortality. The extent to which human leukocyte antigen (HLA) mismatching influences the rate of posttransplant lymphoma has not been clarified...
  61. pmc Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells
    Francesco Vendrame
    Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA
    Diabetes 59:947-57. 2010
    ..To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients...
  62. ncbi Lower variability of tacrolimus trough concentration after conversion from prograf to advagraf in stable kidney transplant recipients
    Ming Ju Wu
    Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Transplantation 92:648-52. 2011
    Variability of blood trough concentration (C0) in immunosuppressant leads to rejection and graft loss after kidney transplantation.
  63. ncbi In vivo effect of bone marrow-derived mesenchymal stem cells in a rat kidney transplantation model with prolonged cold ischemia
    Yoshiaki Hara
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transpl Int 24:1112-23. 2011
    ..In addition, fewer antigen-presenting cells were recruited into the renal allograft. In conclusion, rat MSCs ameliorate inflammation induced by prolonged cold ischemia in kidney transplantation.
  64. ncbi KIR-ligand mismatches are associated with reduced long-term graft survival in HLA-compatible kidney transplantation
    J van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 11:1959-64. 2011
    ..This finding constitutes the first indication that alloreactive NK cells may thwart the success of HLA-compatible kidney transplantations, and suggests that suppression of NK-cell activity can improve the survival of such kidney grafts...
  65. ncbi Machine perfusion or cold storage in deceased-donor kidney transplantation
    Cyril Moers
    Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    N Engl J Med 360:7-19. 2009
    ..Hypothermic machine perfusion may improve outcomes after transplantation, but few sufficiently powered prospective studies have addressed this possibility...
  66. ncbi Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations
    Hans H Hirsch
    Transplantation Virology, Institute for Medical Microbiology and Div Infectious Diseases, Universitatsspital Basel, Switzerland
    Transplantation 79:1277-86. 2005
    ..25-0.33 mg/kg intravenously biweekly) without probenicid should be considered for refractory cases. Retransplantation after renal allograft loss to PVAN remains a treatment option for patients clearing polyomavirus replication...
  67. ncbi A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation
    W D Irish
    Biostatistics and Health Outcomes Research, CTI Clinical Trial and Consulting Services, Cincinnati, OH, USA
    Am J Transplant 10:2279-86. 2010
    ..This tool is useful for predicting DGF and long-term outcomes at the time of transplant...
  68. ncbi All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies
    Po Chang Lee
    Department of Surgery, Medical College, University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan, Taiwan 704
    Transplantation 74:1192-4. 2002
    ..Recent studies show that almost all patients who have rejected a kidney transplant had human leukocyte antigen (HLA) antibodies. In this study, we sought to determine whether patients develop HLA antibodies before chronic rejection...
  69. ncbi Post-transplant renal function in the first year predicts long-term kidney transplant survival
    Sundaram Hariharan
    Division of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Kidney Int 62:311-8. 2002
    ..However, the reasons for this were unclear. This study examined post-transplant renal function within the first year as an independent variable influencing long-term survival...
  70. ncbi The dangers of rationing dialysis treatment: the dilemma facing a developing country
    M R Moosa
    Department of Medicine, Faculty of Health Sciences, University of Stellenbosch and Renal Unit, Tygerberg Academic Hospital, Cape Town, South Africa
    Kidney Int 70:1107-14. 2006
    ..In our experience, socioeconomic factors influenced decision to accept patients more profoundly than medical ones...
  71. ncbi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
    ..The aims of this study were to investigate to which extent HLA-DSA detected by SAFB represent a risk for antibody-mediated rejection (AMR) and diminished allograft survival, and to define HLA-DSA characteristics predictive for AMR...
  72. pmc Predominance of intraglomerular T-bet or GATA3 may determine mechanism of transplant rejection
    Qiquan Sun
    Research Institute of Nephrology, Jinling Hospital, 305 East Zhong Shan Road, Nanjing 210002, China
    J Am Soc Nephrol 22:246-52. 2011
    ..In summary, predominance of intraglomerular T-bet expression correlates with antibody-mediated rejection and resistance to steroid treatment...
  73. ncbi Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy
    S Schaub
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Switzerland
    Am J Transplant 10:2615-23. 2010
    ..6 mg/dl and 1.3 mg/dl, respectively. We conclude that screening for BKV-replication and reduction of immunosuppression is an effective strategy to preserve medium-term allograft function even in patients developing definitive PyVAN...
  74. ncbi Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    Thangamani Muthukumar
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2342-51. 2005
    ..The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy...
  75. ncbi Functionally significant renal allograft rejection is defined by transcriptional criteria
    Steven C Hoffmann
    Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Transplant 5:573-81. 2005
    ..Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts...
  76. ncbi Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus
    F Vincenti
    University of California San Francisco Kidney Transplant Service, San Francisco, CA, USA
    Am J Transplant 7:1506-14. 2007
    ..The incidence of NODAT or IFG at 6 months post-transplant is significantly lower with CsA-ME than with tacrolimus without a significant difference in short-term outcome...
  77. ncbi Preemptive kidney transplantation: the advantage and the advantaged
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, Minnesota 55414, USA
    J Am Soc Nephrol 13:1358-64. 2002
    ..Alterations in the payment system, emphasis on early referral, and changes in cadaver kidney allocation could increase the number of patients who benefit from preemptive transplantation...
  78. ncbi Noninfectious gastrointestinal (GI) complications of mycophenolic acid therapy: a consequence of local GI toxicity?
    W Arns
    Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Transplant Proc 39:88-93. 2007
    ..Research which more closely focuses on the local gut pathobiology of MPA-containing drugs may provide a much clearer understanding of the dose-limiting toxicity of this drug class...
  79. ncbi Malignancy after transplantation
    Joseph F Buell
    Israel Penn International Transplant Tumor Registry, University of Cincinnati, Cincinnati, OH 45267 0558, USA
    Transplantation 80:S254-64. 2005
    ..Long-term data are needed to determine if the use of these agents will ultimately lower the mortality due to malignancy for transplant recipients...
  80. ncbi Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation
    Josep M Campistol
    Hospital Clinic i Provincial, Barcelona, Spain
    J Am Soc Nephrol 17:581-9. 2006
    ..Longer follow-up and additional trials are needed to confirm these promising results...
  81. pmc Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation
    G Andreola
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 11:1236-47. 2011
    ..While regulatory cells may play an early role, long-term tolerance appears to be maintained by a deletion or anergy mechanism...
  82. ncbi Sirolimus and secondary skin-cancer prevention in kidney transplantation
    Sylvie Euvrard
    Department of Dermatology, Hospices Civils de Lyon, Edouard Herriot Hospital Group, Lyon, France
    N Engl J Med 367:329-39. 2012
    ..Transplant recipients in whom cutaneous squamous-cell carcinomas develop are at high risk for multiple subsequent skin cancers. Whether sirolimus is useful in the prevention of secondary skin cancer has not been assessed...
  83. ncbi The histology of solitary renal allografts at 1 and 5 years after transplantation
    M D Stegall
    Von Liebig Transplant Center, Division of Transplantation Surgery, Division of Nephrology and Hypertension, Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:698-707. 2011
    ..and progression of histologic changes using protocol allograft biopsies at 1 and 5 years after solitary kidney transplantation in patients transplanted between 1998 and 2004...
  84. doi Effect on kidney graft survival of reducing or discontinuing maintenance immunosuppression after the first year posttransplant
    Gerhard Opelz
    Transplantation 86:371-6. 2008
    ..Data are scarce concerning the impact of maintenance immunosuppression dose reductions posttransplant...
  85. ncbi Diagnosis and prevention of chronic kidney allograft loss
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    Lancet 378:1428-37. 2011
    b>Kidney transplantation is the best possible treatment for many patients with end-stage renal failure, but progressive dysfunction and eventual allograft loss with return to dialysis is associated with increased mortality and morbidity...
  86. ncbi Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnnesota, USA
    Am J Transplant 5:2464-72. 2005
    ..In conclusion, inflammation and glomerulopathy 1 year post-transplant predict loss of graft function and graft failure independently of function and other variables...
  87. ncbi Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia
    Daniel L Bohl
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Transplant 5:2213-21. 2005
    ..Our data support donor origin for early BKV infection in kidney transplant recipients, and suggest that a specific HLA C locus may be associated with failure to control BKV infection...
  88. pmc Associations of pretransplant weight and muscle mass with mortality in renal transplant recipients
    Elani Streja
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Clin J Am Soc Nephrol 6:1463-73. 2011
  89. ncbi The effect of patients' preferences on racial differences in access to renal transplantation
    J Z Ayanian
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 341:1661-9. 1999
    ..In the United States, black patients undergo renal transplantation less often than white patients, but few studies have directly assessed the association between race and patients' preferences with respect to transplantation...
  90. ncbi Successful renal transplantation in factor H autoantibody associated HUS with CFHR1 and 3 deficiency and CFH variant G2850T
    A M Waters
    Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, and Faculty of Medicine, Imperial College, London, UK
    Am J Transplant 10:168-72. 2010
    ..Furthermore, delineation of the functional significance of CFH-autoantibodies is warranted in individual cases...
  91. ncbi ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a 3-year follow-up
    Helena Genberg
    Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden
    Transplantation 85:1745-54. 2008
    In 2001 a protocol for ABO-incompatible (ABOi) kidney transplantation based on antigen-specific immunoadsorption and rituximab was introduced at our center, short-term results being comparable with those of ABO-compatible (ABOc) living ..
  92. ncbi Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom
    C Mark Taylor
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, UK
    Br J Haematol 148:37-47. 2010
    ..We particularly address the role of renal transplantation alone and combined liver-kidney transplantation.
  93. ncbi Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation
    Yves Caumartin
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    Kidney Int 79:1080-9. 2011
    ..Thus, CORM-2-derived CO protects renal transplants from IRI by modulating inflammation...
  94. pmc Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival
    R L Kedainis
    Department of Internal Medicine, Renal Division, Washington University, St Louis, MO, USA
    Am J Transplant 9:812-9. 2009
    ..There was a clear trend toward worse graft survival in patients with focal C4d+ in this time interval, but focal C4d+ compared to both diffuse C4d+ and C4d-groups was not statistically significant (p = 0.08)...
  95. ncbi Factors contributing to acute rejection in renal transplantation: the role of noncompliance
    P E Morrissey
    Division of Organ Transplantation and Medical Statistics, Rhode Island Hospital, Brown Medical School, 593 Eddy Street APC 921, Providence, RI 02903, USA
    Transplant Proc 37:2044-7. 2005
    ..Future strategies to improve compliance, including increased vigilance in high-risk patient groups, frequent medication review, and laboratory testing, should be encouraged...
  96. pmc Molecular evidence of nosocomial Pneumocystis jirovecii transmission among 16 patients after kidney transplantation
    Sabine Schmoldt
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, University of Munich, Marchioninstrasse 17, 81377 Munich, Germany
    J Clin Microbiol 46:966-71. 2008
    ..jirovecii as the predominant transmission route. Therefore, strict segregation and isolation of P. jirovecii-positive/suspected patients in clinical settings seems warranted...
  97. ncbi Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients
    Pål Falck
    Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway
    Transplantation 85:179-84. 2008
    ..We investigated cyclosporine A (CsA) concentrations at the site of action, inside T-lymphocytes, to evaluate its applicability as a new supplementary therapeutic drug monitoring method after renal transplantation...
  98. ncbi Allocation of deceased donor kidneys for transplantation: opinions of patients with CKD
    Colin C Geddes
    Renal Unit, Western Infirmary, University of Glasgow, Scotland
    Am J Kidney Dis 46:949-56. 2005
    ..The aim of this single-center survey is to seek patient opinion about the relative importance of factors used to determine the optimal transplant recipient in kidney allocation schemes...
  99. ncbi Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state
    Olivier Thaunat
    Department of Renal Transplantation, Hopital Necker Enfants Malades, Paris, France
    Transplantation 80:1212-9. 2005
    ..The responsibility of sirolimus (SRL) for postrenal transplant anemia has never been proven, because SRL is usually combined with myelotoxic drugs, and because of the high incidence of anemia in the posttransplant period...
  100. ncbi Optimization of initial tacrolimus dose using pharmacogenetic testing
    E Thervet
    Department of Renal Transplantation, Assistance Publique Hopitaux de Paris, Necker Enfants Malades Hospital, Paris, France
    Clin Pharmacol Ther 87:721-6. 2010
    ..Pharmacogenetic adaptation of the daily dose of tacrolimus is associated with improved achievement of the target C(0). Whether this improvement will affect clinical outcomes requires further evaluation...
  101. ncbi Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d staining
    Enver Akalin
    Renal Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Clin J Am Soc Nephrol 2:1261-7. 2007
    ..We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms...

Research Grants71

  1. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..kidney disease, with spilling of protein in the urine and, eventually, with the need for dialysis or kidney transplantation. In most cases, the available treatments cannot stop the progression of diabetic kidney disease and the ..
  2. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..not only progressive, in many cases to end stage kidney disease requiring artificial kidney treatments or kidney transplantation, but also contributes greatly to the very high incidence of heart and circulatory disease...
  3. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..They insidiously lead to end- stage kidney disease (ESKD) requiring dialysis or kidney transplantation for survival. 20 million individuals in the U.S...
  4. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..When progression of CKD to end-stage renal disease (ESRD) cannot be prevented, then either dialysis or kidney transplantation are required to prevent immediate mortality...
  5. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..and HTN, (2) Compare the incidence of cardiorenal events (hospitalized heart failure, MI, stroke, ESRD, kidney transplantation, death) among the hypertension categories (3) Compare the prognostic value of two definitions of MHTN (a ..
  6. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease...
  7. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immediately following allogeneic kidney transplantation, the pancreatic beta-cell mass is relentlessly punished by four counterregulatory metabolic factors namely: (1) gluconeogenic surgery-related ..
  8. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2013
    ..loss of protein, and blood in the urine often leads to irreparable damage that ultimately requires a kidney transplantation and/or dialysis to treat the affected patient...
  9. Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study
    Clifford E Kashtan; Fiscal Year: 2013
    ..with Alport syndrome inevitably develop end-stage kidney failure, with a 50% likelihood of dialysis or kidney transplantation by age 25 years...
  10. Novel endonuclease-targeted approaches to nephroprotection
    Alexei G Basnakian; Fiscal Year: 2013
    ..Resulting AKI is a life-threatening condition that requires hemodialysis or kidney transplantation. This proposal is a continuation of the previous research funded by VA Merit Review grant, which was ..
  11. Financial Risks and Ethnic/Racial Disparities in Live Kidney Donation
    TANJALA PURNELL; Fiscal Year: 2011
    ..of Diabetes and Digestive and Kidney Diseases end-stage renal disease target focus of improving rates of kidney transplantation and donation, particularly by African Americans and other ethnic/racial minority groups...
  12. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..circulating endothelial microparticles (EMP) as a novel biomarker of allograft rejection in the setting of kidney transplantation. Endothelial cells (EC) play an important role in the pathogenesis of allograft dysfunction and rejection...
  13. MRI Imaging Biomarkers of ARPKD Kidney and Liver Disease
    Christopher A Flask; Fiscal Year: 2013
    ..complications and contributes to morbidity and mortality in ARPKD patients who have undergone kidney transplantation. Unfortunately, there are currently no established methods for monitoring kidney or liver disease ..
  14. Sphingosine 1 phosphate receptors 1 and 3 as novel targets in transplantation
    Amandeep Bajwa; Fiscal Year: 2013
    ..In the current proposal, we will elucidate: 1) the role of DC S1P1 and S1P3 activation in rodent kidney transplantation model by using genetic approaches (use of S1pr3-/- and DC specific S1pr1-/- mice), 2) the role of S1P ..
  15. Acute Humoral Rejection of Renal Allografts
    Robert L Fairchild; Fiscal Year: 2013
    ..This program comprises three established and interactive investigators who will utilize mouse models of kidney transplantation to address how T cell sensitization impacts allograft reactive antibody production and to identify ..
  16. Role of the complement system in renal disease
    Richard J Quigg; Fiscal Year: 2011
    ..the use of genetically manipulated mice and recombinant proteins, and the techniques of bone marrow and kidney transplantation to determine effects of these proteins in specific cellular populations, relevant cellular pathways ..
  17. Sun protection Internet-based program for kidney transplant recipients
    June K Robinson; Fiscal Year: 2013
    ..b>Kidney transplantation is the treatment of choice for patients with end-stage kidney disease;however, the requisite life-long ..
  18. Kidney Donor Outcomes Cohort (KDOC) Study
    James R Rodrigue; Fiscal Year: 2013
    ..Live donor kidney transplantation (LDKT) is important because its outcomes for recipients are superior to those of deceased donor ..
  19. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..HO-1 in mediating the effects of IL-10 on vascular neointimal proliferation and inflammation in aortic and kidney transplantation using HO-1-/- and HO-1+/+ recipient mice...
  20. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2011 proposal, we seek to perform proof of concept studies in a well-characterized in vivo model of rat kidney transplantation. In Aim 1, we will test the efficacy of anti-CD47 mAb treatment of the donor kidney during cold ischemia ..
  21. Clinical utility of extracellular RNA as marker of kidney disease progression
    Thomas Tuschl; Fiscal Year: 2013
    ..A large proportion of CKD patients develop end stage renal disease and require dialysis or kidney transplantation. Identifying patients at risk for CKD progression may facilitate precision medicine and prevent attendant ..
  22. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    ..Combined liver-kidney transplantation, the definitive treatment of PH1, is not always successful because of large body oxalate stores...
  23. Disparities in Progression to Renal Replacement Therapy
    Stephen F Derose; Fiscal Year: 2011
    ..When the kidneys fail, death inevitably ensues without the aid of dialysis or kidney transplantation. It has long been recognized that African Americans are much more likely to experience end-stage renal ..
  24. Training Program in Hypertension, Kidney Disease &Cell Biology
    Christie P Thomas; Fiscal Year: 2013
    ..Therapies for kidney disease include dialysis and kidney transplantation, but these therapies are imperfect...
  25. Molecular pathways leading to chronic graft dysfunction
    VALERIA RAQUEL MAS; Fiscal Year: 2012
    ..nephropathy (CAN), causes most kidney allograft losses and remains a significant clinical challenge in kidney transplantation (KTx)...
  26. CFTR inhibitors for therapy of polycystic kidney disease
    Alan S Verkman; Fiscal Year: 2010
    ..most common human genetic diseases and a major cause of chronic renal insufficiency requiring dialysis or kidney transplantation. There is compelling evidence that in autosomal dominant polycystic kidney disease (ADPKD) progressive ..
  27. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2013
    ..Here we will to test the CD47humAb in both small (rat) and large (pig) animal models of kidney transplantation. Our specific aims are: Aim 1. Rat kidney SCD and DCD transplants. 1A...
  28. Renal and Cardiovascular Events in Patients with Chronic Kidney Disease
    Akinlolu O Ojo; Fiscal Year: 2013
    ..a) to develop a comprehensive patient-oriented research portfolio in areas of chronic kidney disease and kidney transplantation;and (b) to mentor nephrology trainees in patient-oriented research (POR)...
  29. Culturally Adapted Strategies to Enhance Kidney Donation in Native Communities
    Dedra S Buchwald; Fiscal Year: 2013
    ..Despite similar referral rates for kidney transplantation, AIs are less likely than Whites to be placed on the transplant waiting list or to receive a transplant...
  30. Toxicology studies for gene-modified stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..This treatment would represent a life-long theray that may prevent kidney transplantation and long-term complications associated with cystinosis...
  31. Mechanisms of Acceptance in Mouse Renal Allografts
    Robert B Colvin; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The mouse kidney transplantation system offers an optimal combination of fidelity to human pathological processes, a rich spectrum of ..
  32. Modeling Immune Desensitization in Renal Transplantation
    Martin S Zand; Fiscal Year: 2013
    ..success or failure of immune desensitization in an independent sample of patients undergoing standard immune desensitization for ABO incompatible kidney transplantation, which combines PLEX, IVIG, and plasma- cell depleting therapies. ]
  33. Novel Urinary Proteomic Biomarkers for Acute Renal Transplant Rejection
    Minnie M Sarwal; Fiscal Year: 2010
    ..discovery of diagnostic and prognostic urinary non- invasive biomarkers for acute rejection in pediatric kidney transplantation. Graft survival after kidney transplantation, the treatment of choice for children with end stage kidney ..
  34. In Vivo Assessment of Calcineurin Inhibitor Toxicity in Children
    Joshua M Thurman; Fiscal Year: 2013
    ..cell and vascular endothelial cell metabolism in pediatric patients with nephrotic syndrome and after kidney transplantation are reflected by changes in plasma and urine metabolite patterns, and - plasma and urine metabolite ..
  35. Mineral metabolism disturbances and arteriovenous fistula maturation
    Bryan R Kestenbaum; Fiscal Year: 2013
    ..applicant): More than 450,000 Americans have end stage kidney disease (ESKD), which requires dialysis or kidney transplantation for survival...
  36. Urinary Proteome Monitoring for Transplant Injury
    Minnie M Sarwal; Fiscal Year: 2013
    ..b>Kidney transplantation is the treatment of choice for children with end stage kidney disease...
    Roger D Yusen; Fiscal Year: 2011
    ..lymphocytic bronchiolitis, and an association between DSA and antibody-mediated rejection (AMR) exists in kidney transplantation. To test the hypothesis that treatment-induced depletion of DSA, before the onset of rejection, reduces ..
  38. Enhancing Kidney Donation Through Live Organ Video Educated Donors (LOVED)
    Frank A Treiber; Fiscal Year: 2013
    ..b>Kidney transplantation offers the best outcomes for patients with End Stage Renal Disease (ESRD) but rates of procurement far ..
  39. Frailty and Risk Prediction in Older Adults Considering Kidney Transplantation
    Dorry Segev; Fiscal Year: 2013
    ..On average, older patients who undergo kidney transplantation (KT) have a survival benefit over dialysis...
  40. The comparative effectiveness of kidney transplantation in advanced CKD
    MORGAN ERIKA GRAMS; Fiscal Year: 2013
    ..Preemptive kidney transplantation, or transplantation prior to the initiation of maintenance dialysis, is an increasingly common therapy...
  41. New genes and pathomechanisms of congenital abnormalities of the kidney (CAKUT)
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..Chronic kidney diseases (CKD) take one of the highest tolls on human health, requiring dialysis or kidney transplantation for survival...
  42. The Role of Bicaudal-C in Polycystic Kidney Disease
    Oliver Wessely; Fiscal Year: 2013
    ..They require extensive treatments, such as dialysis and kidney transplantation. Only limited forms of therapy for PKD exist, since the molecular mechanisms underlying the formation of ..
  43. Glucose Modifications of Proteins in Diabetic Nephropathy
    BILLY GERALD HUDSON; Fiscal Year: 2013 nephropathy, end stage renal disease (ESRD) is of great concern given the requirement for dialysis or kidney transplantation to sustain the patient's life...
  44. Understanding Race and Culture in Living Donor Kidney Transplantation
    Larissa Myaskovsky; Fiscal Year: 2013
    ..e., deceased donor kidney transplantation (DDKT) versus living donor kidney transplantation (LDKT)];and, (c) early post-transplant health outcomes...
  45. Cardiovascular Disease in Children with Chronic Kidney Disease
    Mark M Mitsnefes; Fiscal Year: 2013
    ..examine early biological markers of myocardial dysfunction in children on maintenance dialysis and after kidney transplantation: 1) left ventricular myocardial circumferential strain (Ecc), and 2) muscle energy metabolism by ..
  46. Individualizing Therapy for Kidney and Heart Transplant Recipients
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..RELEVANCE: Kidney transplantation and heart transplantation are lifesaving treatments for organ failure, but the transplanted organs do not ..
  47. YKL-40 in Idiopathic Pulmonary Fibrosis and Kidney Transplantation
    Jack A Elias; Fiscal Year: 2013
    ..End of Abstract) ..
  48. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving quality of ..
  49. Novel Targets of Rituximab in FSGS
    SANDRA MONIKA MERSCHER; Fiscal Year: 2013
    ..We propose to utilize a pilot study in all patients with primary FSGS who undergo kidney transplantation as a feeder for the experimental studies...
  50. Pathogenesis of Murine Polyomavirus Allograft Nephropathy
    Kenneth A Newell; Fiscal Year: 2012
    ..this problem, we have developed an unique experimental model of polyomavirus infection in mice following kidney transplantation that mimics many of the important features of BKVN in clinical transplantation...
  51. End-of-life decision making in seriously ill patients: the case of ESRD
    Melissa Wachterman; Fiscal Year: 2011
    ..Although kidney transplantation is an option for some patients, most patients and their families must, at some point, face the difficult ..
  52. Racial and Cardiovascular Risk Factor Anomalies in CKD
    CSABA PAL KOVESDY; Fiscal Year: 2013
    ..higher rates of CKD incidence and/or faster CKD progression, lower mortality, and lower likelihood of kidney transplantation. The anomalous cardiovascular risk factor profile in ESRD could be the result of short-term competing ..
  53. Quantifying risk from and appropriate recipients for infectious-risk kidneys
    Dorry Segev; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Although kidney transplantation offers potentially significant benefit to the tens of thousands of patients on the waiting list, there is ..
    ..referred to as reflux nephropathy and is a major cause of end stage kidney disease requiring dialysis and kidney transplantation in children...
  55. T and B cell Homeostasis After Induction Therapy in Kidney Transplantation
    Fadi G Lakkis; Fiscal Year: 2013
  56. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..2. Kidney Transplantation: 2A...
  57. Monitoring transplant kidney function with MRI
    SEAN BEDILION FAIN; Fiscal Year: 2010
    ..b>Kidney transplantation can replace failed kidney function and offset some of these complications...
  58. Intragraft expression to Predict Future GFR Decline in Kidney Transplantation
    Mark D Stegall; Fiscal Year: 2013
    ..Gene expression appears to identify kidneys that will lose function later, sheds light on the causes of kidney transplant damage and may lead to new therapy that will help transplants last longer. ..
  59. Dopaminergic genetic contributions to obesity in kidney transplant recipients
    Ansley Stanfill; Fiscal Year: 2013
    ..when coupled with how patients respond to their dietary urges, their health and weight status at the time of transplant, and other environmental factors, could explain the weight gain phenomena seen following kidney transplantation.
  60. House Calls and Decision Support: Increasing Access to Live Donor Transplantation
    James R Rodrigue; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): While kidney transplantation is the best treatment option for adults with end-stage renal disease (ESRD), profound racial and socioeconomic disparities persist...
  61. Age, functional status, and survival benefit from kidney transplantation
    Peter Philip Reese; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD), including for older patients with ESRD, but the scarcity of donated kidneys has focused interest on allocating ..
  62. Pathophysiology of Post-Transplantation Cancer
    Soumitro Pal; Fiscal Year: 2013
    ..g., kidney cancer) increase markedly after kidney transplantation. Moreover, different oncogenes including Ras may become activated during the post-transplantation period...
  63. New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas
    Michael Taylor; Fiscal Year: 2009 has been shown to have a major impact in circumventing ischemic injury in kidney transplantation. This proposal seeks to apply this approach to the preservation and procurement of viable islets for ..
    Ali Hassan; Fiscal Year: 2009
    ..prolonged hospital stays and, at the extreme, end-stage kidney disease requiring permanent dialysis and kidney transplantation. Prophylactic procedures for preventing CIN are only marginally effective, and include curtailing ..
    Mita Giacomini; Fiscal Year: 1992
    ..artery bypass, pacemaker implant, carotid endarterectomy, hip arthroplasty/replacement, lithotripsy, kidney transplantation, and surgery for gastrointestinal bleeding...
    Akinlolu Ojo; Fiscal Year: 2001
    Over 30,000 end-stage renal disease (ESRD) patients are waiting for cadaveric kidney transplantation. This number is expected to double in five years...
  67. Social Networks and Pathways to Transplant Parity for Black Hemodialysis Patients
    TERI MARIE BROWNE; Fiscal Year: 2010
    ..that black hemodialysis patients'lack of access to social contacts with useful information about kidney transplantation may hinder information transaction regarding the benefits of, and pathway to, kidney transplantation...
  68. Immunopathogenesis of Chronic Allograft Rejection
    MOHAMED SAYEGH; Fiscal Year: 2005
    The most common cause of late Allograft failure, excluding death with a functioning graft in the case of kidney transplantation, is a clinicopathologic entity termed chronic rejection...
    Ahmed Gaber; Fiscal Year: 2005
    ..islet researchers has a long history of experience in the treatment of diabetes by pancreas and pancreas- kidney transplantation and an extensive experience in human islet isolation, preservation and genetic modification of human ..
  70. Renal Senescence and Transplantation
    Bryan Myers; Fiscal Year: 2007
    Elderly cadaveric donors >60 years old are reluctantly used tbr kidney transplantation (Tx), because an aged renal allograft has been shown to be associated with a short half-life...
  71. Phase I Study of BB3 in Dialysis Patients
    Weizhong Cai; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Kidney transplantation is the most effective therapeutic modality for end-stage renal disease;it offers a better quality of life and a longer survival...