radiotherapy dosage

Summary

Summary: The total amount of radiation absorbed by tissues as a result of radiotherapy.

Top Publications

  1. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
  2. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
  3. doi Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Yamanashi, Japan
    Int J Radiat Oncol Biol Phys 81:1352-8. 2011
  4. ncbi Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial
    David P Dearnaley
    Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK
    Lancet Oncol 8:475-87. 2007
  5. ncbi Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial
    Anthony L Zietman
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 294:1233-9. 2005
  6. ncbi Conformity index: a review
    Loic Feuvret
    Institut Curie, Orsay, France
    Int J Radiat Oncol Biol Phys 64:333-42. 2006
  7. ncbi The hazard of accelerated tumor clonogen repopulation during radiotherapy
    H R Withers
    Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, UCLA
    Acta Oncol 27:131-46. 1988
  8. doi Dosimetric predictor identification for radiation-induced liver disease after hypofractionated conformal radiotherapy for primary liver carcinoma patients with Child-Pugh Grade A cirrhosis
    Shi xiong Liang
    Department of Radiation Oncology, Cancer Hospital, Guangxi Medical University, Nanning, China
    Radiother Oncol 98:265-9. 2011
  9. doi Stereotactic radiotherapy of primary lung cancer and other targets: results of consultant meeting of the International Atomic Energy Agency
    Yasushi Nagata
    Hiroshima University Hospital, Department of Radiation Oncology, Hiroshima, Japan
    Int J Radiat Oncol Biol Phys 79:660-9. 2011
  10. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008

Detail Information

Publications294 found, 100 shown here

  1. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
    ..The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT...
  2. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
    ..75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same...
  3. doi Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Yamanashi, Japan
    Int J Radiat Oncol Biol Phys 81:1352-8. 2011
    ..To review treatment outcomes for stereotactic body radiotherapy (SBRT) in medically operable patients with Stage I non-small-cell lung cancer (NSCLC), using a Japanese multi-institutional database...
  4. ncbi Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial
    David P Dearnaley
    Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK
    Lancet Oncol 8:475-87. 2007
    ..We aimed to present the first analyses of effectiveness from the MRC RT01 randomised controlled trial...
  5. ncbi Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial
    Anthony L Zietman
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 294:1233-9. 2005
    ..Clinically localized prostate cancer is very prevalent among US men, but recurrence after treatment with conventional radiation therapy is common...
  6. ncbi Conformity index: a review
    Loic Feuvret
    Institut Curie, Orsay, France
    Int J Radiat Oncol Biol Phys 64:333-42. 2006
    ..The conformity index is a complementary tool that attributes a score to a treatment plan or that can compare several treatment plans for the same patient. The future of conformal index in everyday practice therefore remains unclear...
  7. ncbi The hazard of accelerated tumor clonogen repopulation during radiotherapy
    H R Withers
    Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, UCLA
    Acta Oncol 27:131-46. 1988
    ....
  8. doi Dosimetric predictor identification for radiation-induced liver disease after hypofractionated conformal radiotherapy for primary liver carcinoma patients with Child-Pugh Grade A cirrhosis
    Shi xiong Liang
    Department of Radiation Oncology, Cancer Hospital, Guangxi Medical University, Nanning, China
    Radiother Oncol 98:265-9. 2011
    ..The aim of this study was to identify dosimetric predictors for RILD in primary liver carcinoma (PLC) patients with Child-Pugh Grade A cirrhosis after hypofractionated conformal radiotherapy (CRT)...
  9. doi Stereotactic radiotherapy of primary lung cancer and other targets: results of consultant meeting of the International Atomic Energy Agency
    Yasushi Nagata
    Hiroshima University Hospital, Department of Radiation Oncology, Hiroshima, Japan
    Int J Radiat Oncol Biol Phys 79:660-9. 2011
    ..Despite the disadvantages expected to be experienced in developing countries, SBRT using fewer fractions may be useful in selected patients with various extracranial cancers with favorable outcome and low toxicity...
  10. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008
    ..To report the incidence and predictors of treatment-related toxicity at 10 years after three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for localized prostate cancer...
  11. ncbi Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial
    Lisa Lowry
    Haematology Trials Group, University College London Cancer Trials Centre, UK
    Radiother Oncol 100:86-92. 2011
    ..This multicentre, prospective, randomised-controlled trial compared efficacy and toxicity of differing radiotherapy doses in non-Hodgkin lymphoma (NHL)...
  12. ncbi Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy
    Stephanie T H Peeters
    Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Clin Oncol 24:1990-6. 2006
    ..To determine whether a dose of 78 Gy improves outcome compared with a conventional dose of 68 Gy for prostate cancer patients treated with three-dimensional conformal radiotherapy...
  13. ncbi Errors and margins in radiotherapy
    Marcel van Herk
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    Semin Radiat Oncol 14:52-64. 2004
    ..In this article, an overview is given of errors in radiotherapy and margin recipes, based on physical and biological considerations. Respiration motion is treated separately...
  14. pmc Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:620-9. 2007
    ..To determine the dosimetric impact of interfraction anatomic movements in prostate cancer patients receiving proton therapy...
  15. doi GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas
    Jean Jacques Mazeron
    Department of Radiation Oncology, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Radiother Oncol 91:150-6. 2009
    ....
  16. ncbi INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy
    Bruce D Minsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:1167-74. 2002
    ..To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 Gy) radiation therapy for the treatment of patients with esophageal cancer...
  17. ncbi Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO)
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland AFB, TX, USA
    Int J Radiat Oncol Biol Phys 74:987-1001. 2009
    ..To present guidance for patients and physicians regarding the use of accelerated partial-breast irradiation (APBI), based on current published evidence complemented by expert opinion...
  18. ncbi Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience
    Nancy Lee
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, L 08, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 53:12-22. 2002
    ..To update our experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma (NPC)...
  19. ncbi Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
    E Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 47:291-8. 2000
    ..To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases...
  20. ncbi Particle radiation therapy using proton and heavier ion beams
    Daniela Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    J Clin Oncol 25:953-64. 2007
    ..Clinical trials investigating proton and carbon ion RT will be summarized and discussed in the context of their relevance to recent concepts of treatment with RT...
  21. ncbi The management of respiratory motion in radiation oncology report of AAPM Task Group 76
    Paul J Keall
    Virginia Commonwealth University, USA
    Med Phys 33:3874-900. 2006
    ..Respiratory motion management is also appropriate when the procedure will increase normal tissue sparing. Respiratory motion management involves further resources, education and the development of and adherence to QA procedures...
  22. pmc Radiation dose-volume effects in the lung
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S70-6. 2010
    ..The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects...
  23. ncbi Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients
    H Blomgren
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    Acta Oncol 34:861-70. 1995
    ..We observed a local rate of no progressive disease of 80% during a follow-up period of 1.5-38 months. Fifty percent of the tumors decreased in size or disappeared...
  24. ncbi Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer
    Nam P Nguyen
    Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
    Oral Oncol 46:283-6. 2010
    ..0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes...
  25. ncbi Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study
    Hiroshi Onishi
    Department of Radiology, School of Medicine, University of Yamanashi, Tamaho cho, Nakakoma gun, Japan
    Cancer 101:1623-31. 2004
    ..The authors retrospectively evaluated results from a Japanese multiinstitutional study...
  26. doi Dynamic jaws and dynamic couch in helical tomotherapy
    Florian Sterzing
    Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 76:1266-73. 2010
    ..To investigate the next generation of helical tomotherapy delivery with dynamic jaw and dynamic couch movements...
  27. ncbi Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate
    Jinka R Sathya
    McMaster University, Hamilton, Ontario, Canada
    J Clin Oncol 23:1192-9. 2005
    ..To determine if iridium implant (IM) and external-beam radiation therapy (EBRT) is better than standard EBRT in locally advanced prostate cancer...
  28. ncbi Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety
    Joseph Wee
    Department of Radiation Oncology, National Cancer Center, Singapore 169610, Republic of Singapore
    J Clin Oncol 23:6730-8. 2005
    ..However, there were controversies regarding the applicability of the results to patients in endemic regions. This study aims to confirm the findings of the 00-99 Trial and its applicability to patients with endemic NPC...
  29. doi Single Arc Volumetric Modulated Arc Therapy of head and neck cancer
    Anders Bertelsen
    Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
    Radiother Oncol 95:142-8. 2010
    ..The VMAT algorithm in Pinnacle is named SmartArc and its capability to generate treatment plans for head and neck cancer was tested...
  30. pmc Radiotherapy dose-volume effects on salivary gland function
    Joseph O Deasy
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 76:S58-63. 2010
    ..Submandibular gland sparing also significantly decreases the risk of xerostomia. The currently available predictive models are imprecise, and additional study is required to identify more accurate models of xerostomia risk...
  31. doi Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial
    Jayant S Vaidya
    Research Department of Surgery, Division of Surgery and Interventional Science, University College London, London, UK
    Lancet 376:91-102. 2010
    ..Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy...
  32. ncbi Secondary neutron dose during proton therapy using spot scanning
    Uwe Schneider
    Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, CH 8063 Zurich, Switzerland
    Int J Radiat Oncol Biol Phys 53:244-51. 2002
    ..In this study, we estimated the neutron dose in patients from a spot scanning beam line by performing measurements and Monte Carlo simulations...
  33. ncbi Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria
    Radiother Oncol 83:148-55. 2007
    ....
  34. ncbi Dose-response relationship in local radiotherapy for hepatocellular carcinoma
    Hee Chul Park
    Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 54:150-5. 2002
    ..This study aimed to determine whether a dose-response relationship exists in local radiotherapy for primary hepatocellular carcinoma (HCC)...
  35. ncbi MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy
    Christine Haie-Meder
    Department of Radiotherapy Brachytherapy Service, Institut Gustave Roussy, Villejuif, France
    Radiother Oncol 96:161-5. 2010
    ..To retrospectively assess the physics contributions and the clinical outcome with preliminary 3D MRI-guided low dose-rate (LDR) intracavitary brachytherapy (BT) experience in locally advanced cervical cancer patients...
  36. ncbi Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies
    Liv Veldeman
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Lancet Oncol 9:367-75. 2008
    ..This review shows evidence of reduced toxicity for various tumour sites by use of IMRT. The findings regarding local control and overall survival are generally inconclusive...
  37. doi Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication
    Seok Hyun Son
    Department of Radiation Oncology, College of Medicine, Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 78:1073-80. 2010
    ..To identify the parameters that predict hepatic toxicity and deterioration of hepatic function...
  38. doi Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control
    Megan E Daly
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 80:1412-22. 2011
    ..Few studies have evaluated the use of intensity-modulated radiotherapy (IMRT) for squamous cell carcinoma (SCC) of the oral cavity (OC). We report clinical outcomes and failure patterns for these patients...
  39. ncbi 18F-fluorodeoxyglucose positron emisson tomography/computed tomography guided conformal brachytherapy for cervical cancer
    Heerim Nam
    Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 84:e29-34. 2012
    ..To evaluate the feasibility of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-guided conformal brachytherapy treatment planning in patients with cervical cancer...
  40. doi Evaluation and optimization of the new EBT2 radiochromic film dosimetry system for patient dose verification in radiotherapy
    L Richley
    Bristol Haematology and Oncology Centre, Bristol BS28ED, UK
    Phys Med Biol 55:2601-17. 2010
    ..Our results suggest that EBT2 film is a valid alternative, rather than a direct replacement for EBT film...
  41. pmc Rotational IMRT techniques compared to fixed gantry IMRT and tomotherapy: multi-institutional planning study for head-and-neck cases
    Tilo Wiezorek
    Department of Radiation Oncology, University of Jena, Jena, Germany
    Radiat Oncol 6:20. 2011
    ..This upcoming treatment technique was benchmarked in a multi-center treatment planning study against static gantry IMRT and rotational IMRT based on a ring gantry for a complex parotid gland sparing head-and-neck technique...
  42. pmc On the benefits and risks of proton therapy in pediatric craniopharyngioma
    Chris Beltran
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 82:e281-7. 2012
    ..We compared photon- and proton-based irradiation methods to determine the effect of tumor volume change on target coverage and normal tissue irradiation in these patients...
  43. ncbi A new homogeneity index based on statistical analysis of the dose-volume histogram
    Myonggeun Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    J Appl Clin Med Phys 8:9-17. 2007
    ..A guideline for evaluating the dose homogeneity of treatment plans based on the S-index and its relation to equivalent uniform dose is discussed...
  44. doi Patterns of care for brachytherapy in Europe: updated results
    Ferran Guedea
    Department of Radiation Oncology, L Hospitalet de Llobregat, Spain
    Radiother Oncol 97:514-20. 2010
    ..This descriptive survey evaluated brachytherapy (BT) practices and resources in the European area. This was a follow-up study to the original patterns of care for brachytherapy in Europe (PCBE)...
  45. pmc Stereotactic body radiation therapy for liver tumours using flattening filter free beam: dosimetric and technical considerations
    Pietro Mancosu
    IRCCS Istituto Clinico Humanitas, Rozzano Milano, Italy
    Radiat Oncol 7:16. 2012
    ..To report the initial institute experience in terms of dosimetric and technical aspects in stereotactic body radiation therapy (SBRT) delivered using flattening filter free (FFF) beam in patients with liver lesions...
  46. ncbi Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy
    Loren K Mell
    Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 66:1356-65. 2006
    ..To identify dosimetric parameters associated with acute hematologic toxicity (HT) and chemotherapy delivery in cervical cancer patients undergoing concurrent chemotherapy and intensity-modulated pelvic radiotherapy...
  47. ncbi Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 68:1375-80. 2007
    ..In the present analysis, we reviewed the acute and chronic toxicity of this IMRT approach compared with conventional wedge-based treatment...
  48. doi Volumetric arc therapy and intensity-modulated radiotherapy for primary prostate radiotherapy with simultaneous integrated boost to intraprostatic lesion with 6 and 18 MV: a planning comparison study
    Piet Ost
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 79:920-6. 2011
    ..Additionally, the use of 6-MV photons was compared with 18-MV photons for all techniques...
  49. ncbi A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    Penny K Sneed
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 53:519-26. 2002
    ..Data collected from 10 institutions were reviewed to compare survival probabilities of patients with newly diagnosed brain metastases managed initially with radiosurgery (RS) alone vs. RS + whole brain radiotherapy (WBRT)...
  50. ncbi A dose-volume analysis of magnetic resonance imaging-aided high-dose-rate image-based interstitial brachytherapy for uterine cervical cancer
    Ken Yoshida
    Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan
    Int J Radiat Oncol Biol Phys 77:765-72. 2010
    ....
  51. doi Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy
    Leah K Schubert
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA
    Radiother Oncol 100:241-6. 2011
    ..To compare left-sided whole breast conventional and intensity-modulated radiotherapy (IMRT) treatment planning techniques...
  52. ncbi Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy
    Min Rao
    Department of Radiation Oncology, Swedish Cancer Institute, 1221 Madison St, Seattle, Washington 98104, USA
    Med Phys 37:1350-9. 2010
    ..The objective of this study is to compare VMAT to both HT and fixed field IMRT in terms of plan quality, delivery efficiency, and accuracy...
  53. doi Feasibility of helical tomotherapy in stereotactic body radiation therapy for centrally located early stage non‒small-cell lung cancer or lung metastases
    Alexander Chi
    Department of Radiation Oncology, The University of Arizona, Tucson, AZ 85724 5081, USA
    Int J Radiat Oncol Biol Phys 81:856-62. 2011
    ..To investigate the ability of helical tomotherapy (HT) to spare critical organs immediately adjacent to the tumor target in stereotactic body radiation therapy (SBRT) for centrally located lung lesions...
  54. ncbi A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    John P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, United Kingdom
    N Engl J Med 350:1200-10. 2004
    ..The effect of adjuvant treatment on survival in pancreatic cancer is unclear. We report the final results of the European Study Group for Pancreatic Cancer 1 Trial and update the interim results...
  55. doi 70 Gy versus 80 Gy in localized prostate cancer: 5-year results of GETUG 06 randomized trial
    Veronique Beckendorf
    Centre Alexis Vautrin, Vandoeuvre les Nancy, France
    Int J Radiat Oncol Biol Phys 80:1056-63. 2011
    ..To perform a randomized trial comparing 70 and 80 Gy radiotherapy for prostate cancer...
  56. doi A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastases
    George Rodrigues
    Department of Oncology, University of Western Ontario and Lawson Health Research Institute, London, ON, Canada
    Radiother Oncol 102:180-6. 2012
    ..To report pooled overall survival and time to radiological intracranial progression results related to arc-based image-guided radiotherapy for dose-escalation of oligometastatic disease of the brain...
  57. ncbi Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma
    Marisol De Brabandere
    Department of Radiation Oncology, University Hospital Leuven, Belgium
    Radiother Oncol 88:217-26. 2008
    ..In this study on PDR treatment planning of utero-vaginal carcinoma, we analysed the dosimetry of traditional X-ray based plans as it presents on MR images. The potential gain of MRI-based dose optimisation was assessed...
  58. ncbi Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy
    Tae Hyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 67:225-31. 2007
    ..To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy...
  59. ncbi Tolerances for the accuracy of photon beam dose calculations of treatment planning systems
    J Venselaar
    Department of Radiotherapy, Dr. B. Verbeeten Institute, P.O. Box 90120, 5000 LA, Tilburg, The Netherlands
    Radiother Oncol 60:191-201. 2001
    ..The new set of tolerances and the quantity confidence limit have proven to be useful tools for the acceptance of photon beam dose calculation algorithms of treatment planning systems...
  60. doi SmartArc-based volumetric modulated arc therapy for oropharyngeal cancer: a dosimetric comparison with both intensity-modulated radiation therapy and helical tomotherapy
    Stefania Clemente
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 80:1248-55. 2011
    ..To investigate the roles of volumetric modulated arc therapy with SmartArc (VMAT-S), intensity-modulated radiation therapy (IMRT), and helical tomotherapy (HT) for oropharyngeal cancer using a simultaneous integrated boost (SIB) approach...
  61. ncbi Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma: dosimetric analysis incorporating quality assurance guidelines from RTOG 0225
    Allen M Chen
    Departments of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140, Sacramento, CA, USA
    Technol Cancer Res Treat 9:291-8. 2010
    ..02), larynx (p = 0.03), and oral cavity (p = 0.03). These findings suggest that HT-IMRT may be of improve the therapeutic ratio in the radiotherapeutic treatment of nasopharyngeal carcinoma...
  62. ncbi Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma
    Jose Luis Guinot
    Department of Radiation Oncology, Fundación Instituto Valenciano de Oncología IVO, Valencia, Spain
    Brachytherapy 9:227-34. 2010
    ..To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas...
  63. doi Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:1-8. 2009
    ....
  64. ncbi On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations
    Antonella Fogliata
    Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    Phys Med Biol 52:1363-85. 2007
    ..035 g cm(-3)), enhanced for the most energetic beam. For denser, and more clinical, densities a better agreement among the sophisticated algorithms with respect to MC was observed...
  65. ncbi Evaluation of the gamma dose distribution comparison method
    Daniel A Low
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Med Phys 30:2455-64. 2003
    ..For clinical cases, the calculation time is typically 5 minutes for a 1 x 1 mm2 interpolated resolution on an 800 MHz Pentium 4 for a 14.1 x 15.2 cm2 radiographic film...
  66. doi Dosimetry audit for a multi-centre IMRT head and neck trial
    Catharine H Clark
    Department of Physics, Royal Marsden NHS Foundation Trust, London, UK
    Radiother Oncol 93:102-8. 2009
    ..The dosimetry audit goals were to verify the plan delivery in participating centres, ascertain what tolerances were suitable for head and neck IMRT trials and develop an IMRT credentialing program...
  67. doi Regional relapse after intensity-modulated radiotherapy for head-and-neck cancer
    Frederic Duprez
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 79:450-8. 2011
    ..To evaluate the regional relapse rate in the elective neck using intensity-modulated radiotherapy (IMRT) for head-and-neck cancer...
  68. doi Risk of hypothyroidism in older breast cancer patients treated with radiation
    Grace L Smith
    Department of Breast Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:1371-9. 2008
    ..The authors assessed risk of hypothyroidism in breast cancer patients who were receiving RT to a supraclavicular field, which typically includes a portion of thyroid...
  69. ncbi Local response and impact on survival after local ablation of liver metastases from colorectal carcinoma by computed tomography-guided high-dose-rate brachytherapy
    Jens Ricke
    Klinik fur Radiologie und Nuklearmedizin, Universitatsklinikum Magdeburg, Germany
    Int J Radiat Oncol Biol Phys 78:479-85. 2010
    ..To determine local tumor control after CT-guided brachytherapy at various dose levels and the prognostic impact of extensive cytoreduction in colorectal liver metastases...
  70. pmc Safety margin in irradiation of colorectal liver metastases: assessment of the control dose of micrometastases
    Max Seidensticker
    Klinik fur Radiologie und Nuklearmedizin, Universitatsklinikum Magdeburg, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:24. 2010
    ..In this study we sought to determine the threshold dose for local control of occult micrometastases in patients undergoing CT (computed tomography)-guided brachytherapy of colorectal liver metastases...
  71. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG)...
  72. doi Dose-volume histogram parameters and local tumor control in magnetic resonance image-guided cervical cancer brachytherapy
    Johannes C A Dimopoulos
    Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    Int J Radiat Oncol Biol Phys 75:56-63. 2009
    ..To investigate the value of dose-volume histogram (DVH) parameters for predicting local control in magnetic resonance (MR) image-guided brachytherapy (IGBT) for patients with cervical cancer...
  73. doi RapidArc planning and delivery in patients with locally advanced head-and-neck cancer undergoing chemoradiotherapy
    Patricia Doornaert
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 79:429-35. 2011
    ..We studied planning and delivery in patients who underwent RapidArc for locally advanced head-and-neck cancer (HNC)...
  74. doi Tolerance and acceptance results of a palladium-103 permanent breast seed implant Phase I/II study
    Jean Philippe Pignol
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 73:1482-8. 2009
    ..To test, in a prospective Phase I/II trial, a partial breast irradiation technique using a 103Pd permanent breast seed implant (PBSI) realized in a single 1-h procedure under sedation and local freezing...
  75. ncbi Surrogate endpoints for overall survival in locally advanced head and neck cancer: meta-analyses of individual patient data
    Stefan Michiels
    Department of Biostatistics and Epidemiology, Institut Gustave Roussy, Villejuif, France
    Lancet Oncol 10:341-50. 2009
    ..This would allow a reduction in the duration and cost of the development of new treatments...
  76. doi From point A to the sculpted pear: MR image guidance significantly improves tumour dose and sparing of organs at risk in brachytherapy of cervical cancer
    Kari Tanderup
    Department of Oncology, Aarhus University Hospital, Noerrebrogade, Aarhus, Denmark
    Radiother Oncol 94:173-80. 2010
    ..The purpose of this study was to compare point doses to 3D dose volume parameters for tumour and organs at risk (OARs), and to evaluate the improvement of dose parameters with MR image guided adaptive brachytherapy (IGABT)...
  77. doi A novel dose constraint to reduce xerostomia in head-and-neck cancer patients treated with intensity-modulated radiotherapy
    Lidia Strigari
    Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy
    Int J Radiat Oncol Biol Phys 77:269-76. 2010
    ....
  78. doi Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma: the University of California-San Francisco experience
    Kim Huang
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California 94143 0226, USA
    Cancer 113:497-507. 2008
    ..Treatment outcomes for stage III and IV oropharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy without prior surgical resection were reviewed...
  79. doi Variation of treatment planning parameters (D90 HR-CTV, D 2cc for OAR) for cervical cancer tandem ring brachytherapy in a multicentre setting: comparison of standard planning and 3D image guided optimisation based on a joint protocol for dose-volume const
    Ina M Jürgenliemk-Schulz
    Department of Radiation Oncology, University Medical Centre Utrecht, The Netherlands
    Radiother Oncol 94:339-45. 2010
    ..To perform a qualitative and quantitative comparison of different treatment planning methods used in different centres for MRI-based brachytherapy (BT) of cervical cancer...
  80. pmc Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases
    Ricarda Ruhl
    Universitatsklinikum Magdeburg, Klinik fur Radiologie und Nuklearmedizin, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:44. 2010
    ..To assess radiobiological restrictions and tolerance doses as well as other toxic effects derived from repeated applications of single-fraction high dose rate irradiation of small liver volumes in clinical practice...
  81. ncbi New inverse planning technology for image-guided cervical cancer brachytherapy: description and evaluation within a clinical frame
    Petra Trnkova
    Department of Radiotherapy, Medical University of Vienna, Austria
    Radiother Oncol 93:331-40. 2009
    ....
  82. ncbi Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results
    Qiuwen Wu
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Int J Radiat Oncol Biol Phys 56:573-85. 2003
    ..The protocol employed stringent dosimetric guidelines in the treatment of locally advanced head-and-neck squamous cell carcinomas (HNSCC) with radiotherapy alone using IMRT and the simultaneous integrated boost (SIB) technique...
  83. ncbi Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Int J Radiat Oncol Biol Phys 57:1247-53. 2003
    ..We present our ongoing clinical experience utilizing 3D conformal radiation therapy (3D-CRT) to deliver partial-breast irradiation (PBI) in patients with early-stage breast cancer treated with breast-conserving therapy...
  84. ncbi The Vienna applicator for combined intracavitary and interstitial brachytherapy of cervical cancer: clinical feasibility and preliminary results
    Johannes C A Dimopoulos
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Int J Radiat Oncol Biol Phys 66:83-90. 2006
    ....
  85. ncbi Selective Internal Radiation Therapy (SIRT) for liver metastases secondary to colorectal adenocarcinoma
    James S Welsh
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 66:S62-73. 2006
    ..It is FDA approved for liver metastases secondary to colorectal carcinoma and is under investigation for treatment of other liver malignancies, such as hepatocellular carcinoma and neuroendocrine malignancies...
  86. ncbi Clinical and physical quality assurance for intensity modulated radiotherapy of prostate cancer
    Dirk Boehmer
    Department of Radiation Oncology, Charité University Clinic Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Radiother Oncol 71:319-25. 2004
    ..Alternative CQA and PQA procedures are discussed. The literature is reviewed and discussed with special respect to quality assurance in IMRT of prostate cancer patients...
  87. ncbi Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer
    Christian Kirisits
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Int J Radiat Oncol Biol Phys 62:901-11. 2005
    ..This study reports the systematic development of our concept applied in clinical routine...
  88. ncbi Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: update of the Memorial Sloan-Kettering experience
    Suzanne L Wolden
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 64:57-62. 2006
    ..We now evaluate whether IMRT has resulted in improved outcomes for a larger cohort of patients with longer follow-up...
  89. ncbi Radiotherapy of malignant gliomas: comparison of volumetric single arc technique (RapidArc), dynamic intensity-modulated technique and 3D conformal technique
    Daniela Wagner
    Radiotherapy and Radiooncology, University Hospital Goettingen, Germany
    Radiother Oncol 93:593-6. 2009
    ..The analysis was designed to identify the optimal radiation technique for patients with malignant glioma...
  90. doi Intensity-modulated arc therapy with simultaneous integrated boost in the treatment of primary irresectable cervical cancer. Treatment planning, quality control, and clinical implementation
    Katrien Vandecasteele
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Strahlenther Onkol 185:799-807. 2009
    ..To report on the planning procedure, quality control, and clinical implementation of intensity-modulated arc therapy (IMAT) delivering a simultaneous integrated boost (SIB) in patients with primary irresectable cervix carcinoma...
  91. ncbi Guidance document on delivery, treatment planning, and clinical implementation of IMRT: report of the IMRT Subcommittee of the AAPM Radiation Therapy Committee
    Gary A Ezzell
    Mayo Clinic, Scottsdale, Arizona 85259, USA
    Med Phys 30:2089-115. 2003
    ..This report, while not prescribing specific procedures, provides the framework and guidance to allow clinical radiation oncology physicists to make judicious decisions in implementing a safe and efficient IMRT program in their clinics...
  92. ncbi How low is the alpha/beta ratio for prostate cancer?
    Jian Z Wang
    Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA
    Int J Radiat Oncol Biol Phys 55:194-203. 2003
    ..In this paper, we present a comprehensive analysis of the updated clinical data to derive a self-consistent set of parameters for the linear-quadratic (LQ) model...
  93. ncbi Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures
    Felix Y Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 68:1289-98. 2007
    ....
  94. ncbi Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life
    A Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Acta Otorhinolaryngol Belg 53:271-5. 1999
    ..The pattern of recurrence suggests that careful escalation of the dose to targets judged to be at highest risk may improve tumor control...
  95. ncbi Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer
    Albert C Koong
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5152, USA
    Int J Radiat Oncol Biol Phys 58:1017-21. 2004
    ..To determine the feasibility and toxicity of delivering stereotactic radiosurgery to patients with locally advanced pancreatic cancer...
  96. doi Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review
    Maurice Tubiana
    Institute Gustave Roussy, Villejuif, France
    Radiother Oncol 91:4-15; discussion 1-3. 2009
    ..In parallel, radiation therapy philosophy must evolve, and the aim of treatment should be to deliver the minimal effective radiation therapy rather than the maximal tolerable dose...
  97. doi Influence of daily setup measurements and corrections on the estimated delivered dose during IMRT treatment of prostate cancer patients
    Paul M A van Haaren
    Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, The Netherlands
    Radiother Oncol 90:291-8. 2009
    ..To evaluate the impact of marker-based position verification, using daily imaging and an off-line correction protocol, by calculating the delivered dose to prostate, rectum and bladder...
  98. ncbi Concurrent chemoradiotherapy with helical tomotherapy for oropharyngeal cancer: a preliminary result
    Pei Wei Shueng
    Department of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 77:715-21. 2010
    ..To review the experience with and evaluate the treatment plan for helical tomotherapy for the treatment of oropharyngeal cancer...
  99. ncbi A technique for the quantitative evaluation of dose distributions
    D A Low
    Mallinckrodt Institute of Radiology, Division of Radiation Oncology, St Louis, Missouri 63110, USA
    Med Phys 25:656-61. 1998
    ..The determination of gamma throughout the measured dose distribution provides a presentation that quantitatively indicates the calculation accuracy. Examples of a 6 MV beam penumbra are used to illustrate the gamma index...
  100. doi Helical tomotherapy as a new treatment technique for whole abdominal irradiation
    Nathalie Rochet
    Department of Radiation Oncology, University of Heidelberg, Germany
    Strahlenther Onkol 184:145-9. 2008
    ..To describe a new intensity-modulated radiotherapy (IMRT) technique using helical tomotherapy for whole abdominal irradiation (WAI) in patients with advanced ovarian cancer...
  101. doi Comparison of PSA relapse-free survival in patients treated with ultra-high-dose IMRT versus combination HDR brachytherapy and IMRT
    Israel Deutsch
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center New York, New York, NY10021, USA
    Brachytherapy 9:313-8. 2010
    ..a lower dose of IMRT combined with high-dose-rate (HDR) brachytherapy to increase the biologically effective dose of IMRT...

Research Grants130 found, 100 shown here

  1. RADIATION INDUCED WHOLE & REGIONAL LUNG INJURY IN HUMANS
    Lawrence Marks; Fiscal Year: 2004
    ..The development, testing and validation of such predictive algorithms will improve patient care by reducing the incidence of lung injury and facilitate "safe" dose escalation for intrathoracic cancers. ..
  2. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2009
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  3. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  4. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2008
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  5. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2006
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  6. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2005
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  7. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  8. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2007
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. [unreadable] [unreadable]..
  9. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2008
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. [unreadable] [unreadable]..
  10. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2006
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. [unreadable] [unreadable]..
  11. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2005
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. ..
  12. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  13. Dose-Response in Radionuclide Therapy
    George Sgouros; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  14. Dose-Response in Radionuclide Therapy
    George Sgouros; Fiscal Year: 2009
    ..abstract_text> ..
  15. Dose-Response in Radionuclide Therapy
    George Sgouros; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2008
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  17. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  18. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2006
    ..The work described in this application is intended to develop and evaluate such an approach. [unreadable] [unreadable]..
  19. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 1999
    ....
  20. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2007
    ..The work described in this application is intended to develop and evaluate such an approach. [unreadable] [unreadable]..
  21. Dose-Response in Radionuclide Therapy
    George Sgouros; Fiscal Year: 2008
    ..abstract_text> ..
  22. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2000
    ....
  23. Dose-Response in Radionuclide Therapy
    George Sgouros; Fiscal Year: 2010
    ..abstract_text> ..
  24. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2001
    ....
  25. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  26. Wine for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2007
    ..3. To explore whether wine in combination with megestrol acetate alters the hormonal milieu that modulates appetite. We will specifically look for alterations of circulating leptin, ghrelin, and neuropeptide y. ..
  27. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  28. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2005
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  29. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2004
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  30. MONTE CARLO TOOLS FOR IMRT
    Chang Ming Ma; Fiscal Year: 2001
    ..abstract_text> ..
  31. Intraoperative Dose Visualization using X-Ray and Ultrasound for Prostate Brachyt
    Danny Song; Fiscal Year: 2010
    ....
  32. Improving Effectiveness and Accuracy of Radiation Therapy
    Rebecca Howell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Improving Effectiveness and Accuracy of Radiation Therapy
    Rebecca Howell; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2003
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  35. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Mohammad Khan; Fiscal Year: 2006
    ....
  36. Multi-Criteria IMRT Optimization
    Thomas Bortfeld; Fiscal Year: 2008
    ..Furthermore, shorter treatment planning times will reduce the overall cost. ..
  37. Wine for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2008
    ..3. To explore whether wine in combination with megestrol acetate alters the hormonal milieu that modulates appetite. We will specifically look for alterations of circulating leptin, ghrelin, and neuropeptide y. ..
  38. Multi-Criteria IMRT Optimization
    Thomas Bortfeld; Fiscal Year: 2006
    ..The navigation tool will be based on a prototype that was used for a preliminary approach with linear objective functions. The new approach will be evaluated using challenging clinical cases. ..
  39. Mentoring and Research in Cancer Palliative Care
    Aminah Jatoi; Fiscal Year: 2008
    ....
  40. Very-High-Frequency Ultrasound Imaging With Coded Signals and Annular Arrays
    Jonathan Mamou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. RADIATION INDUCED WHOLE & REGIONAL LUNG INJURY IN HUMANS
    Lawrence Marks; Fiscal Year: 2002
    ..The development, testing and validation of such predictive algorithms will improve patient care by reducing the incidence of lung injury and facilitate "safe" dose escalation for intrathoracic cancers. ..
  42. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2008
    ..abstract_text> ..
  43. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Mohammad Khan; Fiscal Year: 2007
    ....
  45. Rash from EGFR Inhibitors: Characterization & Palliation of a Symptom Cluster
    Aminah Jatoi; Fiscal Year: 2008
    ..The purpose of this proposal is to better characterize this skin-related symptom cluster from a clinical and basic science standpoint and to test the agent menadione to prevent it all together. ..
  46. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence Marks; Fiscal Year: 2007
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  47. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Mohammad Khan; Fiscal Year: 2008
    ....
  48. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  49. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2008
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
  50. Management of Breathing effects in Radiotherapy Planning
    Thomas Bortfeld; Fiscal Year: 2009
    ....
  51. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence Marks; Fiscal Year: 2009
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  52. Wine for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2009
    ..3. To explore whether wine in combination with megestrol acetate alters the hormonal milieu that modulates appetite. We will specifically look for alterations of circulating leptin, ghrelin, and neuropeptide y. ..
  53. PBeam: Fast and Easy Monte Carlo System for Proton Therapy
    Harald Paganetti; Fiscal Year: 2009
    ....
  54. Prediction of Pathologic Complete Response by Gene Expression Profiling in Esopha
    Jaffer A Ajani; Fiscal Year: 2010
    ..Our goal is to pave the way for a strategy in the future that will allow administration of effective therapy, improve safety, and preserve the esophagus in some patients. ..
  55. Management of Breathing effects in Radiotherapy Planning
    Thomas R Bortfeld; Fiscal Year: 2010
    ....
  56. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence B Marks; Fiscal Year: 2010
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  57. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  58. Multi-Criteria IMRT Optimization
    Thomas R Bortfeld; Fiscal Year: 2010
    ..Furthermore, shorter treatment planning times will reduce the overall cost. ..
  59. Human Breast Cancer Stem Cell Surrogates
    Massimo Cristofanilli; Fiscal Year: 2009
    ..This approach could be used to select patients for individualized therapy using targeted sensitizing agents based on the proposed preclinical studies. ..
  60. RADIATION INDUCED WHOLE & REGIONAL LUNG INJURY IN HUMANS
    Lawrence Marks; Fiscal Year: 2003
    ..The development, testing and validation of such predictive algorithms will improve patient care by reducing the incidence of lung injury and facilitate "safe" dose escalation for intrathoracic cancers. ..
  61. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  62. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence Marks; Fiscal Year: 2007
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  63. Image-guided Adaptive IMRT for Head and Neck Cancer
    David Schwartz; Fiscal Year: 2008
    ....
  64. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2005
    ..abstract_text> ..
  65. Molecular Markers of Response to Chemoradiation in Localized Esophageal Cancer
    Jaffer Ajani; Fiscal Year: 2008
    ..Our goal is to pave the way for a strategy in the future that will allow administration of effective therapy, improve safety, and preserve the esophagus in some patients. ..
  66. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2005
    ....
  67. Multi-Criteria IMRT Optimization
    Thomas Bortfeld; Fiscal Year: 2005
    ..The navigation tool will be based on a prototype that was used for a preliminary approach with linear objective functions. The new approach will be evaluated using challenging clinical cases. ..
  68. Wine for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2010
    ..3. To explore whether wine in combination with megestrol acetate alters the hormonal milieu that modulates appetite. We will specifically look for alterations of circulating leptin, ghrelin, and neuropeptide y. ..
  69. Multi-Criteria IMRT Optimization
    Thomas Bortfeld; Fiscal Year: 2004
    ..The navigation tool will be based on a prototype that was used for a preliminary approach with linear objective functions. The new approach will be evaluated using challenging clinical cases. ..
  70. Mechanisms and Therapeutics in Cancer Anorexia/Cachexia
    Aminah Jatoi; Fiscal Year: 2004
    ..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
  71. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2009
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
  72. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence Marks; Fiscal Year: 2008
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  73. Thick scintillation detector with continuous positioning & DOI capability for PET
    Suleman Surti; Fiscal Year: 2008
    ..Hence, thick continuous detectors have the potential to significantly impact the clinical imaging situation and the resultant patient treatment. [unreadable] [unreadable] [unreadable]..
  74. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2008
    ..Under- standing the mechanisms regulating scleral remodeling may point the way toward targets for drug intervention to one day control myopia progression. ..
  75. Dynamic multi-organ anatomical models for hypofractionated RT design and delivery
    Kristy Brock; Fiscal Year: 2010
    ..This enhanced patient model will allow improved accuracy in the design and implementation of treatment. ..
  76. Molecular Characterization of p53R2 in Head and Neck Ca
    Stuart Wong; Fiscal Year: 2004
    ..We will identify and characterize the frequency of p53R2 gene SNPs in HNSCC patients and test the hypothesis that p53R2 gene SNPs predict adverse normal tissue radiation effects in HNSCC patients treated with radiation. ..
  77. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2007
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  78. IMRT Guided by Magnetic Resonance Spectroscopic Imaging
    Lei Xing; Fiscal Year: 2006
    ..In addition, the dose optimization framework will be equally applicable to biologically-guided IMRT incorporating functional information from other modalities including PET and molecular imaging. ..
  79. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2006
    ..We will develop and evaluate influence diagrams for prostate cancer and for head & neck cancer. [unreadable] [unreadable]..
  80. Statistical Methods--3D Conformal Radiation Therapy Data
    Jeremy Taylor; Fiscal Year: 2003
    ..The methods will be applied to repeated measures saliva flow measurements from the parotid for patients treated with 3D conformal radiation therapy for head and neck cancer. ..
  81. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2005
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  82. Signal Transduction Pathways in Glioblastoma
    Arnab Chakravarti; Fiscal Year: 2006
    ....
  83. A Time-of-Flight PET scanner for dedicated breast imaging
    Suleman Surti; Fiscal Year: 2009
    ..Hence, the development of a dedicated, TOF, breast scanner has the potential to significantly impact patient treatment for breast cancer. ..
  84. PBeam: Fast and Easy Monte Carlo System for Proton Therapy
    Harald Paganetti; Fiscal Year: 2010
    ....
  85. IMRT Dose Optimization
    Lei Xing; Fiscal Year: 2007
    ..Thus it will likely result in a measurable improvement in treatment outcome and have a widespread impact on cancer management. [unreadable] [unreadable] [unreadable]..
  86. Human Breast Cancer Stem Cell Surrogates
    WENDY A contact WOODWARD; Fiscal Year: 2010
    ..This approach could be used to select patients for individualized therapy using targeted sensitizing agents based on the proposed preclinical studies. ..
  87. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2008
    ..We will develop and evaluate influence diagrams for prostate cancer and for head & neck cancer. ..
  88. A Time-of-Flight PET scanner for dedicated breast imaging
    Suleman Surti; Fiscal Year: 2010
    ..Hence, the development of a dedicated, TOF, breast scanner has the potential to significantly impact patient treatment for breast cancer. ..
  89. Phase II validation of 4-dimensional computed tomography derived ventilation for
    Thomas Guerrero; Fiscal Year: 2007
    ..Our new imaging method uses equipment already available in almost every radiation oncology clinic. This study seeks to validate our new ventilation imaging with the present standard method. [unreadable] [unreadable] [unreadable]..
  90. MECHANISMS OF OCULAR DEVELOPMENT
    THOMAS NORTON; Fiscal Year: 2004
    ..Understanding the mechanisms regulating scleral remodeling may point the way toward targets for drug intervention to one-day control myopia progression. ..
  91. Management of Breathing effects in Radiotherapy Planning
    Thomas Bortfeld; Fiscal Year: 2008
    ....
  92. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  93. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Nadeem Khan; Fiscal Year: 2010
    ....
  94. Virotherapy for Relapsed Refractory Multiple Myeloma
    Angela Dispenzieri; Fiscal Year: 2010
    ..MV-NIS, given by vein, should kill myeloma cells. Using simple scans, we should be able to track where MV-NIS goes in the body. ..
  95. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Mohammad Khan; Fiscal Year: 2009
    ....
  96. Monitoring Oxygen Repeatedly for Hypoxic Tumor Therapy
    Mohammad Khan; Fiscal Year: 2007
    ..If successful, this approach potentially could be immediately extended for clinical applications. [unreadable] [unreadable] [unreadable]..
  97. Virotherapy for Relapsed Refractory Multiple Myeloma
    Angela Dispenzieri; Fiscal Year: 2009
    ..MV-NIS, given by vein, should kill myeloma cells. Using simple scans, we should be able to track where MV-NIS goes in the body. ..