radiotherapy dosage

Summary

Summary: The total amount of radiation absorbed by tissues as a result of radiotherapy.

Top Publications

  1. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
  2. ncbi Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Austria
    Radiother Oncol 78:67-77. 2006
  3. ncbi Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience
    Michael K M Kam
    Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 60:1440-50. 2004
  4. ncbi Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer
    Deborah A Kuban
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 70:67-74. 2008
  5. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
  6. ncbi Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Yamanashi, Japan
    Int J Radiat Oncol Biol Phys 81:1352-8. 2011
  7. ncbi Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety
    Joseph Wee
    Department of Radiation Oncology, National Cancer Center, Singapore 169610, Republic of Singapore
    J Clin Oncol 23:6730-8. 2005
  8. ncbi Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study
    Hiroshi Onishi
    Department of Radiology, School of Medicine, University of Yamanashi, Tamaho cho, Nakakoma gun, Japan
    Cancer 101:1623-31. 2004
  9. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
  10. ncbi Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience
    Nancy Lee
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, L 08, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 53:12-22. 2002

Detail Information

Publications325 found, 100 shown here

  1. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG)...
  2. ncbi Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Austria
    Radiother Oncol 78:67-77. 2006
    ..However, prospective use of these recommendations in the clinical context is warranted, to further explore and develop the potential of 3D image-based cervix cancer brachytherapy...
  3. ncbi Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience
    Michael K M Kam
    Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 60:1440-50. 2004
    ..To evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of nasopharyngeal carcinoma (NPC), including the role of dose escalation above 66 Gy level...
  4. ncbi Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer
    Deborah A Kuban
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 70:67-74. 2008
    ..To report the long-term results of a randomized radiotherapy dose escalation trial for prostate cancer...
  5. ncbi Intensity-modulated radiation therapy, protons, and the risk of second cancers
    Eric J Hall
    Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1-7. 2006
    ..The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT...
  6. ncbi Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Yamanashi, Japan
    Int J Radiat Oncol Biol Phys 81:1352-8. 2011
    ..To review treatment outcomes for stereotactic body radiotherapy (SBRT) in medically operable patients with Stage I non-small-cell lung cancer (NSCLC), using a Japanese multi-institutional database...
  7. ncbi Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety
    Joseph Wee
    Department of Radiation Oncology, National Cancer Center, Singapore 169610, Republic of Singapore
    J Clin Oncol 23:6730-8. 2005
    ..However, there were controversies regarding the applicability of the results to patients in endemic regions. This study aims to confirm the findings of the 00-99 Trial and its applicability to patients with endemic NPC...
  8. ncbi Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study
    Hiroshi Onishi
    Department of Radiology, School of Medicine, University of Yamanashi, Tamaho cho, Nakakoma gun, Japan
    Cancer 101:1623-31. 2004
    ..The authors retrospectively evaluated results from a Japanese multiinstitutional study...
  9. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
    ..75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same...
  10. ncbi Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience
    Nancy Lee
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, L 08, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 53:12-22. 2002
    ..To update our experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma (NPC)...
  11. ncbi Conformity index: a review
    Loic Feuvret
    Institut Curie, Orsay, France
    Int J Radiat Oncol Biol Phys 64:333-42. 2006
    ..The conformity index is a complementary tool that attributes a score to a treatment plan or that can compare several treatment plans for the same patient. The future of conformal index in everyday practice therefore remains unclear...
  12. pmc Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer
    Richard Potter
    Department of Radiotherapy, Medical University of Vienna, Austria
    Radiother Oncol 100:116-23. 2011
    ..To analyse the overall clinical outcome and benefits by applying protocol based image guided adaptive brachytherapy combined with 3D conformal external beam radiotherapy (EBRT)±chemotherapy (ChT)...
  13. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008
    ..To report the incidence and predictors of treatment-related toxicity at 10 years after three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for localized prostate cancer...
  14. ncbi Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial
    David P Dearnaley
    Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK
    Lancet Oncol 8:475-87. 2007
    ..We aimed to present the first analyses of effectiveness from the MRC RT01 randomised controlled trial...
  15. ncbi Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial
    Anthony L Zietman
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 294:1233-9. 2005
    ..Clinically localized prostate cancer is very prevalent among US men, but recurrence after treatment with conventional radiation therapy is common...
  16. ncbi Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial
    Jayant S Vaidya
    Research Department of Surgery, Division of Surgery and Interventional Science, University College London, London, UK
    Lancet 376:91-102. 2010
    ..Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy...
  17. ncbi Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Regina V Tse
    Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 26:657-64. 2008
    ..To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC)...
  18. ncbi Dosimetric predictor identification for radiation-induced liver disease after hypofractionated conformal radiotherapy for primary liver carcinoma patients with Child-Pugh Grade A cirrhosis
    Shi xiong Liang
    Department of Radiation Oncology, Cancer Hospital, Guangxi Medical University, Nanning, China
    Radiother Oncol 98:265-9. 2011
    ..The aim of this study was to identify dosimetric predictors for RILD in primary liver carcinoma (PLC) patients with Child-Pugh Grade A cirrhosis after hypofractionated conformal radiotherapy (CRT)...
  19. ncbi Physical radiotherapy treatment planning based on functional PET/CT data
    Daniela Thorwarth
    Section for Biomedical Physics, University Hospital for Radiation Oncology, Tubingen, Germany
    Radiother Oncol 96:317-24. 2010
    ..Nevertheless, molecular imaging has the potential to significantly improve target volume delineation and might also serve as a basis for treatment alteration in the future...
  20. pmc Rotational IMRT techniques compared to fixed gantry IMRT and tomotherapy: multi-institutional planning study for head-and-neck cases
    Tilo Wiezorek
    Department of Radiation Oncology, University of Jena, Jena, Germany
    Radiat Oncol 6:20. 2011
    ..This upcoming treatment technique was benchmarked in a multi-center treatment planning study against static gantry IMRT and rotational IMRT based on a ring gantry for a complex parotid gland sparing head-and-neck technique...
  21. ncbi Intensity-modulated radiation therapy in the salvage of locally recurrent nasopharyngeal carcinoma
    Sufang Qiu
    Department of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, People s Republic of China
    Int J Radiat Oncol Biol Phys 83:676-83. 2012
    ..The aim of this study was to address the efficacy and toxicity profile of IMRT for a cohort of patients with locally recurrent NPC...
  22. ncbi Targeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: an alternative to standard total body irradiation
    Jeffrey Y C Wong
    Division of Radiation Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
    Biol Blood Marrow Transplant 12:306-15. 2006
    ..Ongoing clinical trials will define the maximum TMI and TMLI doses achievable and define the potential advantages and limitations of this new approach for patients undergoing hematopoietic stem cell transplantation...
  23. pmc Radiation dose-volume effects in radiation-induced rectal injury
    Jeff M Michalski
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 76:S123-9. 2010
    ..It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions...
  24. ncbi Nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy: report on the 3-year outcome of a prospective series
    Shaojun Lin
    Department of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, People s Republic of China
    Int J Radiat Oncol Biol Phys 75:1071-8. 2009
    ..To evaluate the efficacy of intensity-modulated radiotherapy (IMRT) using reduced clinical target volumes (CTV) in the treatment of nasopharyngeal carcinoma (NPC)...
  25. ncbi Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO)
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland AFB, TX, USA
    Int J Radiat Oncol Biol Phys 74:987-1001. 2009
    ..To present guidance for patients and physicians regarding the use of accelerated partial-breast irradiation (APBI), based on current published evidence complemented by expert opinion...
  26. ncbi Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication
    Seok Hyun Son
    Department of Radiation Oncology, College of Medicine, Catholic University of Korea, Seoul, Korea
    Int J Radiat Oncol Biol Phys 78:1073-80. 2010
    ..To identify the parameters that predict hepatic toxicity and deterioration of hepatic function...
  27. ncbi Errors and margins in radiotherapy
    Marcel van Herk
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    Semin Radiat Oncol 14:52-64. 2004
    ..In this article, an overview is given of errors in radiotherapy and margin recipes, based on physical and biological considerations. Respiration motion is treated separately...
  28. pmc Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 78:1244-52. 2010
    ..Herein we report our preliminary experience with whole-brain radiotherapy using hippocampal sparing for patients with brain metastases...
  29. ncbi Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study
    Achilles J Fakiris
    Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN 46202, USA
    Int J Radiat Oncol Biol Phys 75:677-82. 2009
    ..The 50-month results of a prospective Phase II trial of stereotactic body radiation therapy (SBRT) in medically inoperable patients are reported...
  30. ncbi The hazard of accelerated tumor clonogen repopulation during radiotherapy
    H R Withers
    Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, UCLA
    Acta Oncol 27:131-46. 1988
    ....
  31. ncbi High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study
    Feng Ming Kong
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 63:324-33. 2005
    ..To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC)...
  32. ncbi Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial
    Lisa Lowry
    Haematology Trials Group, University College London Cancer Trials Centre, UK
    Radiother Oncol 100:86-92. 2011
    ..This multicentre, prospective, randomised-controlled trial compared efficacy and toxicity of differing radiotherapy doses in non-Hodgkin lymphoma (NHL)...
  33. ncbi Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy
    Stephanie T H Peeters
    Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Clin Oncol 24:1990-6. 2006
    ..To determine whether a dose of 78 Gy improves outcome compared with a conventional dose of 68 Gy for prostate cancer patients treated with three-dimensional conformal radiotherapy...
  34. ncbi The impact of IMRT and proton radiotherapy on secondary cancer incidence
    Uwe Schneider
    Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, Triemli Hospital Zurich, 8063 Zurich, Switzerland
    Strahlenther Onkol 182:647-52. 2006
    ..Therefore, X-ray scatter and neutron radiation as well as the impact of the primary dose distribution on secondary cancer incidence are analyzed...
  35. ncbi Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma
    S G Urba
    University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Oncol 19:305-13. 2001
    ..We designed a randomized trial to compare survival for patients treated with this preoperative chemoradiation regimen versus surgery alone...
  36. ncbi Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy
    David Palma
    Radiation Oncology Program, British Columbia Cancer Agency, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 72:996-1001. 2008
    ..The goal of this study was to compare VMAT prostate RT plans with three-dimensional conformal RT (3D-CRT) and IMRT plans...
  37. ncbi Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
    E Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 47:291-8. 2000
    ..To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases...
  38. ncbi Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 68:491-8. 2007
    ..To compare the contours and dose-volume histograms (DVH) of the tumor and organs at risk (OAR) with computed tomography (CT) vs. magnetic resonance imaging (MRI) in cervical cancer brachytherapy...
  39. ncbi Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy
    Min Rao
    Department of Radiation Oncology, Swedish Cancer Institute, 1221 Madison St, Seattle, Washington 98104, USA
    Med Phys 37:1350-9. 2010
    ..The objective of this study is to compare VMAT to both HT and fixed field IMRT in terms of plan quality, delivery efficiency, and accuracy...
  40. ncbi GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas
    Jean Jacques Mazeron
    Department of Radiation Oncology, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Radiother Oncol 91:150-6. 2009
    ....
  41. pmc Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:620-9. 2007
    ..To determine the dosimetric impact of interfraction anatomic movements in prostate cancer patients receiving proton therapy...
  42. ncbi INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy
    Bruce D Minsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:1167-74. 2002
    ..To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 Gy) radiation therapy for the treatment of patients with esophageal cancer...
  43. ncbi Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial
    A T C Chan
    Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    J Clin Oncol 20:2038-44. 2002
    ..Nasopharyngeal carcinoma (NPC) is highly sensitive to both radiotherapy (RT) and chemotherapy. This randomized phase III trial compared concurrent cisplatin-RT (CRT) with RT alone in patients with locoregionally advanced NPC...
  44. pmc Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410
    Walter J Curran
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, 1365C Clifton Rd, NE, Ste C4104, Atlanta, GA 30322, USA
    J Natl Cancer Inst 103:1452-60. 2011
    ..However, it is not known whether sequential or concurrent delivery of these therapies is the optimal combination strategy...
  45. ncbi Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer
    Eric K Hansen
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 64:355-62. 2006
    ..We conducted this retrospective study to determine the dosimetric effects of repeat computed tomography (CT) imaging and replanning during the course of intensity-modulated radiotherapy (IMRT) on both normal tissues and target volumes...
  46. ncbi The management of respiratory motion in radiation oncology report of AAPM Task Group 76
    Paul J Keall
    Virginia Commonwealth University, USA
    Med Phys 33:3874-900. 2006
    ..Respiratory motion management is also appropriate when the procedure will increase normal tissue sparing. Respiratory motion management involves further resources, education and the development of and adherence to QA procedures...
  47. ncbi Particle radiation therapy using proton and heavier ion beams
    Daniela Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    J Clin Oncol 25:953-64. 2007
    ..Clinical trials investigating proton and carbon ion RT will be summarized and discussed in the context of their relevance to recent concepts of treatment with RT...
  48. ncbi Dose-response relationship in local radiotherapy for hepatocellular carcinoma
    Hee Chul Park
    Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 54:150-5. 2002
    ..This study aimed to determine whether a dose-response relationship exists in local radiotherapy for primary hepatocellular carcinoma (HCC)...
  49. ncbi SmartArc-based volumetric modulated arc therapy for oropharyngeal cancer: a dosimetric comparison with both intensity-modulated radiation therapy and helical tomotherapy
    Stefania Clemente
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 80:1248-55. 2011
    ..To investigate the roles of volumetric modulated arc therapy with SmartArc (VMAT-S), intensity-modulated radiation therapy (IMRT), and helical tomotherapy (HT) for oropharyngeal cancer using a simultaneous integrated boost (SIB) approach...
  50. ncbi Bladder dose accumulation based on a biomechanical deformable image registration algorithm in volumetric modulated arc therapy for prostate cancer
    E S Andersen
    Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark
    Phys Med Biol 57:7089-100. 2012
    ..Large variations were found in individual patients between the doses from the initial treatment plan and the accumulated bladder doses. Hence, the use of repeat imaging has a potential for improved accuracy in treatment dose reporting...
  51. ncbi Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer
    Robert Timmerman
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Chest 124:1946-55. 2003
    ..We set out to investigate a new therapy akin to brain radiosurgery called extracranial stereotactic radioablation (ESR) in a phase I trial...
  52. ncbi Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship
    Peter C Levendag
    Department of Radiation Oncology, Erasmus Medical Center Daniel den Hoed, Rotterdam, The Netherlands
    Radiother Oncol 85:64-73. 2007
    ..To assess the relationship between the radiation therapy (RT) dose received by the muscular components of the swallowing (sw) apparatus and - dysphagia related - quality of life (QoL) in oropharyngeal cancer...
  53. ncbi Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:1-8. 2009
    ....
  54. ncbi Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients
    H Blomgren
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    Acta Oncol 34:861-70. 1995
    ..We observed a local rate of no progressive disease of 80% during a follow-up period of 1.5-38 months. Fifty percent of the tumors decreased in size or disappeared...
  55. ncbi Dynamic jaws and dynamic couch in helical tomotherapy
    Florian Sterzing
    Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 76:1266-73. 2010
    ..To investigate the next generation of helical tomotherapy delivery with dynamic jaw and dynamic couch movements...
  56. ncbi Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer
    Nam P Nguyen
    Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
    Oral Oncol 46:283-6. 2010
    ..0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes...
  57. ncbi Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer
    Stephanie T H Peeters
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 64:1151-61. 2006
    ..To identify dosimetric parameters derived from anorectal, rectal, and anal wall dose distributions that correlate with different late gastrointestinal (GI) complications after three-dimensional conformal radiotherapy for prostate cancer...
  58. ncbi Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 C, Aarhus, Denmark
    Lancet 362:933-40. 2003
    ..We aimed to find out whether shortening of treatment time by use of six instead of five radiotherapy fractions per week improves the tumour response in squamous-cell carcinoma...
  59. ncbi Randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy for stage IIIB non-small-cell lung cancer: cancer and leukemia group B study 9431
    Everett E Vokes
    University of Chicago Medical Center and Cancer and Leukemia Group B, Chicago, IL, USA
    J Clin Oncol 20:4191-8. 2002
    ....
  60. ncbi Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy
    Tae Hyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 67:225-31. 2007
    ..To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy...
  61. pmc Radiation dose-volume effects in the lung
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S70-6. 2010
    ..The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects...
  62. ncbi A dose-volume analysis of magnetic resonance imaging-aided high-dose-rate image-based interstitial brachytherapy for uterine cervical cancer
    Ken Yoshida
    Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan
    Int J Radiat Oncol Biol Phys 77:765-72. 2010
    ....
  63. ncbi Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate
    Jinka R Sathya
    McMaster University, Hamilton, Ontario, Canada
    J Clin Oncol 23:1192-9. 2005
    ..To determine if iridium implant (IM) and external-beam radiation therapy (EBRT) is better than standard EBRT in locally advanced prostate cancer...
  64. ncbi Single Arc Volumetric Modulated Arc Therapy of head and neck cancer
    Anders Bertelsen
    Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
    Radiother Oncol 95:142-8. 2010
    ..The VMAT algorithm in Pinnacle is named SmartArc and its capability to generate treatment plans for head and neck cancer was tested...
  65. pmc Radiotherapy dose-volume effects on salivary gland function
    Joseph O Deasy
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 76:S58-63. 2010
    ..Submandibular gland sparing also significantly decreases the risk of xerostomia. The currently available predictive models are imprecise, and additional study is required to identify more accurate models of xerostomia risk...
  66. ncbi Secondary neutron dose during proton therapy using spot scanning
    Uwe Schneider
    Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, CH 8063 Zurich, Switzerland
    Int J Radiat Oncol Biol Phys 53:244-51. 2002
    ..In this study, we estimated the neutron dose in patients from a spot scanning beam line by performing measurements and Monte Carlo simulations...
  67. ncbi Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria
    Radiother Oncol 83:148-55. 2007
    ....
  68. ncbi Stereotactic radiotherapy of primary lung cancer and other targets: results of consultant meeting of the International Atomic Energy Agency
    Yasushi Nagata
    Hiroshima University Hospital, Department of Radiation Oncology, Hiroshima, Japan
    Int J Radiat Oncol Biol Phys 79:660-9. 2011
    ..Despite the disadvantages expected to be experienced in developing countries, SBRT using fewer fractions may be useful in selected patients with various extracranial cancers with favorable outcome and low toxicity...
  69. ncbi Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer--a systematic review
    George Rodrigues
    Department of Radiation Oncology, London Regional Cancer Centre, London, Ontario, Canada
    Radiother Oncol 71:127-38. 2004
    ....
  70. ncbi A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    John P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, United Kingdom
    N Engl J Med 350:1200-10. 2004
    ..The effect of adjuvant treatment on survival in pancreatic cancer is unclear. We report the final results of the European Study Group for Pancreatic Cancer 1 Trial and update the interim results...
  71. pmc Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects
    D P Dearnaley
    Academic Department of Radiotherapy and Oncology, Institute of Cancer Research, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 92:488-98. 2005
    ..Data from this randomised pilot study informed the Data Monitoring Committee of the Medical Research Council RT 01 Trial and the two studies will be combined in subsequent meta-analysis...
  72. ncbi Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication
    Jason Chia Hsien Cheng
    Department of Radiation Oncology, Koo Foundation Sun Yat Sen Cancer Center, No 125 Lih Der Road, Pei tou District, Taipei 112, Taiwan
    Int J Radiat Oncol Biol Phys 54:156-62. 2002
    ....
  73. ncbi Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer
    Dirk Wolff
    Department of Radiation Oncology of the University Medical Center Mannheim, University of Heidelberg, Germany
    Radiother Oncol 93:226-33. 2009
    ..This analysis compares VMAT against established IMRT and 3D-conformal radiation therapy (3D-CRT) delivery techniques...
  74. ncbi Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy
    M Guerrero
    Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA
    Phys Med Biol 49:4825-35. 2004
    ..This work indicates that the standard LQ model can lead to erroneous results when used to calculate iso-effects with large fraction doses, such as those used for ESR. We present a solution to this problem...
  75. ncbi MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy
    Christine Haie-Meder
    Department of Radiotherapy Brachytherapy Service, Institut Gustave Roussy, Villejuif, France
    Radiother Oncol 96:161-5. 2010
    ..To retrospectively assess the physics contributions and the clinical outcome with preliminary 3D MRI-guided low dose-rate (LDR) intracavitary brachytherapy (BT) experience in locally advanced cervical cancer patients...
  76. ncbi Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies
    Liv Veldeman
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Lancet Oncol 9:367-75. 2008
    ..This review shows evidence of reduced toxicity for various tumour sites by use of IMRT. The findings regarding local control and overall survival are generally inconclusive...
  77. ncbi Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control
    Megan E Daly
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 80:1412-22. 2011
    ..Few studies have evaluated the use of intensity-modulated radiotherapy (IMRT) for squamous cell carcinoma (SCC) of the oral cavity (OC). We report clinical outcomes and failure patterns for these patients...
  78. ncbi 18F-fluorodeoxyglucose positron emisson tomography/computed tomography guided conformal brachytherapy for cervical cancer
    Heerim Nam
    Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 84:e29-34. 2012
    ..To evaluate the feasibility of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-guided conformal brachytherapy treatment planning in patients with cervical cancer...
  79. ncbi Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 68:1375-80. 2007
    ..In the present analysis, we reviewed the acute and chronic toxicity of this IMRT approach compared with conventional wedge-based treatment...
  80. pmc On the benefits and risks of proton therapy in pediatric craniopharyngioma
    Chris Beltran
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 82:e281-7. 2012
    ..We compared photon- and proton-based irradiation methods to determine the effect of tumor volume change on target coverage and normal tissue irradiation in these patients...
  81. ncbi Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy
    Loren K Mell
    Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 66:1356-65. 2006
    ..To identify dosimetric parameters associated with acute hematologic toxicity (HT) and chemotherapy delivery in cervical cancer patients undergoing concurrent chemotherapy and intensity-modulated pelvic radiotherapy...
  82. ncbi A new homogeneity index based on statistical analysis of the dose-volume histogram
    Myonggeun Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    J Appl Clin Med Phys 8:9-17. 2007
    ..A guideline for evaluating the dose homogeneity of treatment plans based on the S-index and its relation to equivalent uniform dose is discussed...
  83. ncbi Evaluation and optimization of the new EBT2 radiochromic film dosimetry system for patient dose verification in radiotherapy
    L Richley
    Bristol Haematology and Oncology Centre, Bristol BS28ED, UK
    Phys Med Biol 55:2601-17. 2010
    ..Our results suggest that EBT2 film is a valid alternative, rather than a direct replacement for EBT film...
  84. ncbi Patterns of care for brachytherapy in Europe: updated results
    Ferran Guedea
    Department of Radiation Oncology, L Hospitalet de Llobregat, Spain
    Radiother Oncol 97:514-20. 2010
    ..This descriptive survey evaluated brachytherapy (BT) practices and resources in the European area. This was a follow-up study to the original patterns of care for brachytherapy in Europe (PCBE)...
  85. pmc Stereotactic body radiation therapy for liver tumours using flattening filter free beam: dosimetric and technical considerations
    Pietro Mancosu
    IRCCS Istituto Clinico Humanitas, Rozzano Milano, Italy
    Radiat Oncol 7:16. 2012
    ..To report the initial institute experience in terms of dosimetric and technical aspects in stereotactic body radiation therapy (SBRT) delivered using flattening filter free (FFF) beam in patients with liver lesions...
  86. ncbi 70 Gy versus 80 Gy in localized prostate cancer: 5-year results of GETUG 06 randomized trial
    Veronique Beckendorf
    Centre Alexis Vautrin, Vandoeuvre les Nancy, France
    Int J Radiat Oncol Biol Phys 80:1056-63. 2011
    ..To perform a randomized trial comparing 70 and 80 Gy radiotherapy for prostate cancer...
  87. ncbi Feasibility of helical tomotherapy in stereotactic body radiation therapy for centrally located early stage non‒small-cell lung cancer or lung metastases
    Alexander Chi
    Department of Radiation Oncology, The University of Arizona, Tucson, AZ 85724 5081, USA
    Int J Radiat Oncol Biol Phys 81:856-62. 2011
    ..To investigate the ability of helical tomotherapy (HT) to spare critical organs immediately adjacent to the tumor target in stereotactic body radiation therapy (SBRT) for centrally located lung lesions...
  88. ncbi Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy
    Leah K Schubert
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA
    Radiother Oncol 100:241-6. 2011
    ..To compare left-sided whole breast conventional and intensity-modulated radiotherapy (IMRT) treatment planning techniques...
  89. ncbi A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    Penny K Sneed
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 53:519-26. 2002
    ..Data collected from 10 institutions were reviewed to compare survival probabilities of patients with newly diagnosed brain metastases managed initially with radiosurgery (RS) alone vs. RS + whole brain radiotherapy (WBRT)...
  90. ncbi Volumetric arc therapy and intensity-modulated radiotherapy for primary prostate radiotherapy with simultaneous integrated boost to intraprostatic lesion with 6 and 18 MV: a planning comparison study
    Piet Ost
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 79:920-6. 2011
    ..Additionally, the use of 6-MV photons was compared with 18-MV photons for all techniques...
  91. ncbi A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastases
    George Rodrigues
    Department of Oncology, University of Western Ontario and Lawson Health Research Institute, London, ON, Canada
    Radiother Oncol 102:180-6. 2012
    ..To report pooled overall survival and time to radiological intracranial progression results related to arc-based image-guided radiotherapy for dose-escalation of oligometastatic disease of the brain...
  92. ncbi Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma
    Marisol De Brabandere
    Department of Radiation Oncology, University Hospital Leuven, Belgium
    Radiother Oncol 88:217-26. 2008
    ..In this study on PDR treatment planning of utero-vaginal carcinoma, we analysed the dosimetry of traditional X-ray based plans as it presents on MR images. The potential gain of MRI-based dose optimisation was assessed...
  93. ncbi Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma
    Jose Luis Guinot
    Department of Radiation Oncology, Fundación Instituto Valenciano de Oncología IVO, Valencia, Spain
    Brachytherapy 9:227-34. 2010
    ..To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas...
  94. ncbi Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma: dosimetric analysis incorporating quality assurance guidelines from RTOG 0225
    Allen M Chen
    Departments of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140, Sacramento, CA, USA
    Technol Cancer Res Treat 9:291-8. 2010
    ..02), larynx (p = 0.03), and oral cavity (p = 0.03). These findings suggest that HT-IMRT may be of improve the therapeutic ratio in the radiotherapeutic treatment of nasopharyngeal carcinoma...
  95. ncbi Tolerances for the accuracy of photon beam dose calculations of treatment planning systems
    J Venselaar
    Department of Radiotherapy, Dr. B. Verbeeten Institute, P.O. Box 90120, 5000 LA, Tilburg, The Netherlands
    Radiother Oncol 60:191-201. 2001
    ..The new set of tolerances and the quantity confidence limit have proven to be useful tools for the acceptance of photon beam dose calculation algorithms of treatment planning systems...
  96. ncbi On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations
    Antonella Fogliata
    Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    Phys Med Biol 52:1363-85. 2007
    ..035 g cm(-3)), enhanced for the most energetic beam. For denser, and more clinical, densities a better agreement among the sophisticated algorithms with respect to MC was observed...
  97. ncbi Evaluation of the gamma dose distribution comparison method
    Daniel A Low
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Med Phys 30:2455-64. 2003
    ..For clinical cases, the calculation time is typically 5 minutes for a 1 x 1 mm2 interpolated resolution on an 800 MHz Pentium 4 for a 14.1 x 15.2 cm2 radiographic film...
  98. ncbi Regional relapse after intensity-modulated radiotherapy for head-and-neck cancer
    Frederic Duprez
    Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 79:450-8. 2011
    ..To evaluate the regional relapse rate in the elective neck using intensity-modulated radiotherapy (IMRT) for head-and-neck cancer...
  99. ncbi Dose-volume histogram parameters and local tumor control in magnetic resonance image-guided cervical cancer brachytherapy
    Johannes C A Dimopoulos
    Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    Int J Radiat Oncol Biol Phys 75:56-63. 2009
    ..To investigate the value of dose-volume histogram (DVH) parameters for predicting local control in magnetic resonance (MR) image-guided brachytherapy (IGBT) for patients with cervical cancer...
  100. ncbi RapidArc planning and delivery in patients with locally advanced head-and-neck cancer undergoing chemoradiotherapy
    Patricia Doornaert
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 79:429-35. 2011
    ..We studied planning and delivery in patients who underwent RapidArc for locally advanced head-and-neck cancer (HNC)...
  101. pmc Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases
    Ricarda Ruhl
    Universitatsklinikum Magdeburg, Klinik fur Radiologie und Nuklearmedizin, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:44. 2010
    ..To assess radiobiological restrictions and tolerance doses as well as other toxic effects derived from repeated applications of single-fraction high dose rate irradiation of small liver volumes in clinical practice...

Research Grants43

  1. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  2. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2008
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. [unreadable] [unreadable]..
  3. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  4. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  5. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  6. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  7. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2005
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  8. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  9. Very-High-Frequency Ultrasound Imaging With Coded Signals and Annular Arrays
    Jonathan Mamou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Mechanisms and Therapeutics in Cancer Anorexia/Cachexia
    Aminah Jatoi; Fiscal Year: 2004
    ..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
  11. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2009
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
  12. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  14. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  15. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..
  16. PSA BASED EARLY DETECTION OF PROSTATE CANCER RECURRENCE
    Jeremy Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  17. Four-dimensional IMAT planning using graph algorithms
    Cedric X Yu; Fiscal Year: 2010
    ..Successful achievement of the aforementioned project aims will provide planning and practical image guidance for the safe and efficient delivery of IMAT, and significantly improve cancer treatments. ..
  18. Phase II validation of 4-dimensional computed tomography derived ventilation for
    Thomas Guerrero; Fiscal Year: 2008
    ..Our new imaging method uses equipment already available in almost every radiation oncology clinic. This study seeks to validate our new ventilation imaging with the present standard method. [unreadable] [unreadable] [unreadable]..
  19. Spinal Cord Tolerance to Radiosurgical Dose Delivery
    Paul M Medin; Fiscal Year: 2010
    ....
  20. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2009
    ..We will develop and evaluate influence diagrams for prostate cancer and for head &neck cancer. ..
  21. IMRT Dose Optimization
    Lei Xing; Fiscal Year: 2009
    ..Thus it will likely result in a measurable improvement in treatment outcome and have a widespread impact on cancer management. ..
  22. Signal Transduction Pathways in Glioblastoma
    Arnab Chakravarti; Fiscal Year: 2009
    ....
  23. Genetic Consequences of Therapies for Cancer
    John Boice; Fiscal Year: 2009
    ..abstract_text> ..
  24. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. [unreadable] [unreadable] [unreadable]..
  25. Analysis Methods for Volume-Outcome Studies
    Katherine Panageas; Fiscal Year: 2005
    ..Our methodological research will heighten awareness of clustering in health policy studies. Upon completion of our research plan, we will make recommendations about various analytic strategies for clustered binary data. ..
  26. Pretargeting mouse tumor with anti-PSMA antibody-MORF
    Guozheng Liu; Fiscal Year: 2005
    ..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
  27. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  28. Temporal Variation of Organ Dose Distribution in RT
    Di Yan; Fiscal Year: 2007
    ..Explore practical methods to include temporal variation of organ dose distribution, estimated from image feedback, in treatment planning optimization. ..
  29. TRIMODAL GENE THERAPY FOR PROSTATE CANCER
    SVEND FREYTAG; Fiscal Year: 2003
    ....
  30. IMRT Guided by Magnetic Resonance Spectroscopic Imaging
    Lei Xing; Fiscal Year: 2006
    ..In addition, the dose optimization framework will be equally applicable to biologically-guided IMRT incorporating functional information from other modalities including PET and molecular imaging. ..
  31. Thick scintillation detector with continuous positioning & DOI capability for PET
    Suleman Surti; Fiscal Year: 2008
    ..Hence, thick continuous detectors have the potential to significantly impact the clinical imaging situation and the resultant patient treatment. [unreadable] [unreadable] [unreadable]..
  32. Molecular Characterization of p53R2 in Head and Neck Ca
    Stuart Wong; Fiscal Year: 2004
    ..We will identify and characterize the frequency of p53R2 gene SNPs in HNSCC patients and test the hypothesis that p53R2 gene SNPs predict adverse normal tissue radiation effects in HNSCC patients treated with radiation. ..
  33. Oxygen Guided Hypofractionated Radiotherapy for Gliomas
    Nadeem Khan; Fiscal Year: 2010
    ....
  34. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  35. Development of EPR and NIR Oximetry for Diabetic Foot
    Mohammad Khan; Fiscal Year: 2007
    ..If the promise of these techniques is fulfilled, clinicians will have a new powerful tool for management of peripheral vascular disease, based on fundamental pathophysiology. [unreadable] [unreadable] [unreadable]..
  36. Monitoring Oxygen Repeatedly for Hypoxic Tumor Therapy
    Mohammad Khan; Fiscal Year: 2007
    ..If successful, this approach potentially could be immediately extended for clinical applications. [unreadable] [unreadable] [unreadable]..
  37. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..The research plan will attempt to exploit the many unique features of the SEC, namely its reusability, high sensitivity and LET discrimination. ..
  38. Gamma Ray Spectroscopy for Dose Rate Constants
    Ravinder Nath; Fiscal Year: 2006
    ..abstract_text> ..
  39. DOSIMETRY OF BRACHYTHERAPY SOURCES IN MILLIMETER RANGE
    Ravinder Nath; Fiscal Year: 2003
    ..The goals of the project are to develop tools for the optimization of dose distributions produced within a target volume and uniformity of dose along and around a blood vessel. ..
  40. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2005
    ..A Petri-dish-like micro SEC will be developed for the determination of doses at the interface of high Z materials and tissues with capability of measuring doses averaged over layers of about 10 pm thickness. ..