bone transplantation

Summary

Summary: The grafting of bone from a donor site to a recipient site.

Top Publications

  1. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
  2. ncbi Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    J C Banwart
    Section of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, USA
    Spine (Phila Pa 1976) 20:1055-60. 1995
  3. ncbi The biology of bone grafting
    Safdar N Khan
    Department of Orthopaedic Surgery, The University of California, Davis, Davis, CA, USA
    J Am Acad Orthop Surg 13:77-86. 2005
  4. ncbi Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells
    Le Wang
    Institute of Orthopaedics and Traumatology, The Third Affiliated Hospital, Guangzhou Medical University, People s Republic of China
    Biomaterials 31:9452-61. 2010
  5. ncbi Bone tissue engineering: state of the art and future trends
    Antonio J Salgado
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Macromol Biosci 4:743-65. 2004
  6. ncbi Polyetheretherketone as a biomaterial for spinal applications
    Jeffrey M Toth
    Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Box 26099, Milwaukee, WI 53226 0099, USA
    Biomaterials 27:324-34. 2006
  7. ncbi Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty
    Tajeshwar S Aulakh
    RJAH Orthopaedic Hospital, Oswestry, UK
    Biomaterials 30:1732-8. 2009
  8. pmc Alloprosthetic composite is a suitable reconstruction after periacetabular tumor resection
    Davide Donati
    Orthopaedic Surgery, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Clin Orthop Relat Res 469:1450-8. 2011
  9. ncbi Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis
    John R Dimar
    Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 40202, USA
    J Bone Joint Surg Am 91:1377-86. 2009
  10. ncbi Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution
    Xiaohui Niu
    Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
    J Bone Joint Surg Am 94:461-7. 2012

Research Grants

  1. Adult Stem Cells: Osteoblast Differentiation and Engraftment
    David W Rowe; Fiscal Year: 2011
  2. ENDOCHONDRAL BONE FORMATION IN RENAL FAILURE
    ISIDRO SALUSKY; Fiscal Year: 1999
  3. Biodegradable Scaffolds for Periodontal Void-Filling
    DEBRA TRANTOLO; Fiscal Year: 2001
  4. STRUCTURE AND METABOLISM OF VASCULARIZED ALLOGRAFTS
    Victor Goldberg; Fiscal Year: 1993
  5. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
  6. Prospective evaluation of immediate temporized implants
    Michael Block; Fiscal Year: 2007
  7. Protein Biomarkers in Lung Allograft Rejection
    CHRIS H WENDT; Fiscal Year: 2010
  8. Na, K-ATPase Regulation by Glucocorticoids in Lung
    Chris Wendt; Fiscal Year: 2007
  9. NONLINEAR STRESS-STRAIN BEHAVIOR OF CORTICAL BONE
    DWIGHT DAVY; Fiscal Year: 2004
  10. Functional Health CAT in Diabetes
    Carolyn Schwartz; Fiscal Year: 2004

Detail Information

Publications289 found, 100 shown here

  1. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
    ..We present here an overview of bone grafts and graft substitutes available for clinical applications...
  2. ncbi Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    J C Banwart
    Section of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, USA
    Spine (Phila Pa 1976) 20:1055-60. 1995
    ..The findings suggest that procedural refinements of limiting subcutaneous dissection and providing layered tension-free incision closure may improve results...
  3. ncbi The biology of bone grafting
    Safdar N Khan
    Department of Orthopaedic Surgery, The University of California, Davis, Davis, CA, USA
    J Am Acad Orthop Surg 13:77-86. 2005
    ..An elegant cellular and molecular cascade follows bone transplantation. Bone graft incorporation within the host, whether autogenous or allogeneic, depends on many factors: type ..
  4. ncbi Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells
    Le Wang
    Institute of Orthopaedics and Traumatology, The Third Affiliated Hospital, Guangzhou Medical University, People s Republic of China
    Biomaterials 31:9452-61. 2010
    ....
  5. ncbi Bone tissue engineering: state of the art and future trends
    Antonio J Salgado
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Macromol Biosci 4:743-65. 2004
    ..Scaffolds processed by using a methodology based on extrusion with blowing agents...
  6. ncbi Polyetheretherketone as a biomaterial for spinal applications
    Jeffrey M Toth
    Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Box 26099, Milwaukee, WI 53226 0099, USA
    Biomaterials 27:324-34. 2006
    ..Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer's increased radiolucency and decreased stiffness...
  7. ncbi Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty
    Tajeshwar S Aulakh
    RJAH Orthopaedic Hospital, Oswestry, UK
    Biomaterials 30:1732-8. 2009
    ..62). We conclude that long-term prosthesis survival and function following revision arthroplasty with a 50/50 mixture of allograft and hydroxyapatite are comparable to allograft alone...
  8. pmc Alloprosthetic composite is a suitable reconstruction after periacetabular tumor resection
    Davide Donati
    Orthopaedic Surgery, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Clin Orthop Relat Res 469:1450-8. 2011
    ..However, while such composites restore anatomy and function of the pelvis the use of pelvic allografts is controversial and the durability is unknown...
  9. ncbi Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis
    John R Dimar
    Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 40202, USA
    J Bone Joint Surg Am 91:1377-86. 2009
    ....
  10. ncbi Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution
    Xiaohui Niu
    Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
    J Bone Joint Surg Am 94:461-7. 2012
    ..The present study was designed to review the epidemiological characteristics and outcomes of surgical management in a large series of Chinese patients with giant cell tumor of an extremity, treated at a single institution...
  11. ncbi Prospective study of iliac crest bone graft harvest site pain and morbidity
    David H Kim
    Department of Orthopedic Surgery, Tufts University School of Medicine, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Spine J 9:886-92. 2009
    ..The most frequently reported complication associated with graft harvest is chronic pain...
  12. ncbi Histological examination of frozen autograft treated by liquid nitrogen removed after implantation
    Yoshikazu Tanzawa
    Department of Orthopaedic Surgery, Kanazawa University School of Medicine, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Orthop Sci 14:761-8. 2009
    ..To determine if frozen autografts exhibit early bone remodeling, we investigated the repair processes of the frozen bones...
  13. ncbi Autologous bone graft: properties and techniques
    Hans Christoph Pape
    Department of Orthopaedic Trauma Surgery, University of Aachen, Aachen, Germany
    J Orthop Trauma 24:S36-40. 2010
    ..This review article summarizes the biologic and mechanical properties of autologous bone grafts, differentiates various autologous bone graft types, and compares them with other bone substitutes...
  14. ncbi Fresh cortical autograft versus fresh cortical allograft effects on experimental bone healing in rabbits: radiological, histopathological and biomechanical evaluation
    Z Shafiei
    Department of Surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
    Cell Tissue Bank 10:19-26. 2009
    ..05). Autograft was superior to allograft at the 28th and 42nd postoperative day in radiological evaluation (P < 0.03). Histopathological and biomechanical evaluation revealed no significant differences between two groups...
  15. ncbi Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review
    Rozalia Dimitriou
    Department of Trauma and Orthopaedic Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Injury 42:S3-15. 2011
    ....
  16. ncbi Tissue engineering of bone: material and matrix considerations
    Yusuf Khan
    University of Virginia School of Medicine, 400 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:36-42. 2008
    ....
  17. ncbi Fresh-frozen structural allografts in the foot and ankle
    Mark S Myerson
    Union Memorial Hospital, Baltimore, Maryland, USA
    J Bone Joint Surg Am 87:113-20. 2005
    ..These grafts were used in order to restore more normal dimensions of the foot and ankle following surgery or trauma and to treat arthritis or deformity in situations in which conventional cancellous graft would not be sufficient...
  18. ncbi The compatibility of ceramic bone graft substitutes as allograft extenders for use in impaction grafting of the femur
    A W Blom
    Department of Orthopaedic Surgery, Bristol Royal Infirmary, Bristol, England, UK
    J Bone Joint Surg Br 87:421-5. 2005
    ..There was no statistically significant difference between the four groups after 18 months of unrestricted functional loading for all outcome measures...
  19. ncbi Reconstruction using an autograft containing tumour treated by liquid nitrogen
    H Tsuchiya
    Kanazawa University, Kanazawa, Japan
    J Bone Joint Surg Br 87:218-25. 2005
    ..All were managed successfully. Our results suggest that this is a simple and effective method of biological reconstruction...
  20. pmc Allograft-prosthetic composite in the proximal tibia after bone tumor resection
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40126 Bologna, Italy
    Clin Orthop Relat Res 466:459-65. 2008
    ..We believe the ideal candidate is the young patient with a benign aggressive or malignant low-grade tumor who has not undergone previous surgery...
  21. ncbi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
    ..The purpose of this study was to evaluate the type of materials used and their efficacy for the treatment of large bone defects in traumatology and orthopaedic surgery...
  22. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008
    ..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone defects...
  23. ncbi Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects
    Marcus Jager
    Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Orthop Res 29:173-80. 2011
    ..BMAC combined with HA can reduce the time needed for healing of bone defects when compared to BMAC in combination with collagen sponge...
  24. ncbi Fractures through bone cysts: unicameral bone cysts, aneurysmal bone cysts, fibrous cortical defects, and nonossifying fibromas
    John P Dormans
    Children s Hospital of Philadelphia, Division of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Instr Course Lect 51:457-67. 2002
  25. pmc The effect of soaking allograft in bisphosphonate: a pilot dose-response study
    Thomas Jakobsen
    Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    Clin Orthop Relat Res 468:867-74. 2010
    ..Long-term survival of uncemented total joint replacements relies on osseointegration. With reduced bone stock impacted morselized allograft enhances early implant fixation but is subject to resorption...
  26. ncbi Reconstruction of the mandible with osseous free flaps: a 10-year experience with 150 consecutive patients
    P G Cordeiro
    Plastic and Reconstructive Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 104:1314-20. 1999
    ..The ilium is recommended only when other options are unavailable. Thoughtful flap selection and design should supplant the need for multiple, simultaneous free flaps and vein grafting in most cases...
  27. ncbi Effects of hydrogen peroxide cleaning procedures on bone graft osteoinductivity and mechanical properties
    C A DePaula
    Musculoskeletal Transplant Foundation, Edison, NJ 08837, USA
    Cell Tissue Bank 6:287-98. 2005
    ..The improved cleaning procedure therefore did not compromise the strength or osteoinductivity of cortical bone allografts in comparison to the standard procedure...
  28. ncbi Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop
    Ulrich Kneser
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Erlangen, Germany
    Tissue Eng 12:1721-31. 2006
    ..Our aim was to induce axial vascularization in a processed bovine cancellous bone (PBCB) matrix using an arteriovenous (AV) loop (artery, vein graft, and vein)...
  29. ncbi Tissue-engineered bone regeneration
    H Petite
    Laboratoire de Recherches Orthopediques, CNRS UPRES A 7052, Université D Diderot, Faculte de Medecine, Lariboisière Saint Louis, 10 Avenue de Verdun, 75010 Paris, France
    Nat Biotechnol 18:959-63. 2000
    ..Clinical union never occurred when the defects were left empty or filled with the scaffold alone. In contrast, clinical union was obtained in three out of seven operated limbs when the defects were filled with the tissue-engineered bone...
  30. ncbi Effects of ionizing radiation on the mechanical properties of human bone
    J D Currey
    Department of Biology, University of York, England, U K
    J Orthop Res 15:111-7. 1997
    ....
  31. ncbi Alveolar cleft osteoplasty using tissue-engineered osteogenic material
    H Hibi
    Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Int J Oral Maxillofac Surg 35:551-5. 2006
    ..1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge...
  32. pmc Antibacterial activity of bone allografts: comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin
    Constantinos Ketonis
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Bone 48:631-8. 2011
    ..Since the tethered antibiotic appeared to have little or no effect on any of these activities, it was concluded that the stable, tethered antibiotic prevented bacterial infection while not modifying bone cell function...
  33. ncbi In vitro analysis of anterior and posterior fixation in an experimental unstable burst fracture model
    Patricia M Kallemeier
    University of Minnesota, Minneapolis, MN, USA
    J Spinal Disord Tech 21:216-24. 2008
    ..A biomechanical comparison of fixation constructs in an experimental fracture model...
  34. ncbi Impaction grafting of the acetabulum with a mixture of frozen, ground irradiated bone graft and porous synthetic bone substitute (Apapore 60)
    I McNamara
    Department of Orthopaedics, West Suffolk Hospital, Bury St Edmunds, UK
    J Bone Joint Surg Br 92:617-23. 2010
    ..Longer follow-up will be required to establish whether this technique is as effective as using fresh-frozen allograft...
  35. ncbi Histologic analysis of allograft mixed with hydroxyapatite-tricalcium phosphate used in revision femoral impaction bone grafting
    Takaaki Fujishiro
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Orthopedics 31:277. 2008
    ....
  36. pmc Allogenic versus autologous cancellous bone in lumbar segmental spondylodesis: a randomized prospective study
    Michael Putzier
    Klinik für Orthopädie, Centrum für Muskuloskeletale Chirurgie, Charite, Universitatsmedizin Berlin, Charite Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Eur Spine J 18:687-95. 2009
    ..The results demonstrated an equivalent clinical outcome, as well as similar fusion rates following a 12-month period. This is in despite of a delayed consolidation process...
  37. pmc Single-level cervical radiculopathy: clinical outcome and cost-effectiveness of four techniques of anterior cervical discectomy and fusion and disc arthroplasty
    Arup K Bhadra
    Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP, UK
    Eur Spine J 18:232-7. 2009
    ..Single-level cervical radiculopathy was treated with four different techniques. The clinical outcome and cost-effectiveness were compared in this study...
  38. ncbi Is combining massive bone allograft with free vascularized fibular flap the children's reconstruction answer to lower limb defects following bone tumour resection?
    T Jager
    Department of Paediatric Orthopaedic Surgery, Nancy University Hospital Center, Children s Hospital, Vandoeuvre, France
    Orthop Traumatol Surg Res 96:340-7. 2010
    ..The first one is intended to withstand mechanical stress, and the second one offers biological and vascular support to improve bone healing and prevent infections...
  39. ncbi Graft options in posterolateral and posterior interbody lumbar fusion
    Jeffrey A Rihn
    The Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 35:1629-39. 2010
    ..Review article, review of literature...
  40. ncbi Aneurysmal bone cyst: a review of 150 patients
    Henry J Mankin
    Orthopedic Oncology Service, Orthopedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 23:6756-62. 2005
    ..We have reviewed a series of 150 aneurysmal bone cysts treated over the last 20 years...
  41. ncbi Bone augmentation procedures in implant dentistry
    Matteo Chiapasco
    Unit of Oral Surgery, Department of Medicine, Surgery and Dentistry, San Paolo Hospital, University of Milan, Via Beldiletto 1 3, 20142 Milan, Italy
    Int J Oral Maxillofac Implants 24:237-59. 2009
    ..This review evaluated (1) the success of different surgical techniques for the reconstruction of edentulous deficient alveolar ridges and (2) the survival/success rates of implants placed in the augmented areas...
  42. ncbi Maxillary ridge augmentation with fresh-frozen bone allografts
    Cintia Mussi Milani Contar
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
    J Oral Maxillofac Surg 67:1280-5. 2009
    ..The present investigation clinically and histologically evaluated the use of fresh-frozen bone in the reconstruction of maxillary alveolar ridges to confirm the effective bone fill and support for the placement of dental implants...
  43. pmc Impaction bone grafting of the acetabulum at hip revision using a mix of bone chips and a biphasic porous ceramic bone graft substitute
    Ashley W Blom
    Department of Academic Orthopaedics, University of Bristol, BIRC Research Labs, Avon Orthopaedic Centre, Bristol
    Acta Orthop 80:150-4. 2009
    ..Previous in vitro and in vivo studies have yielded good results using mixtures of allograft and BoneSave, when compared with allograft alone. This study is the first reported human clinical trial of BoneSave in impaction grafting...
  44. pmc Nonvascularized bone grafting defers joint arthroplasty in hip osteonecrosis
    Thorsten M Seyler
    Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Reconstruction, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
    Clin Orthop Relat Res 466:1125-32. 2008
    ..With the addition of ancillary growth factors, these procedures effectively reduce donor site morbidity and may defer joint arthroplasty in selected patients...
  45. ncbi Cost comparison of femoral head banking versus bone substitutes
    Hon Bong Leung
    Department of Orthopaedics and Traumatology, Queen Mary Hospital, Pokfulam, Hong Kong
    J Orthop Surg (Hong Kong) 18:50-4. 2010
    ..To compare the costs of femoral head banking versus bone substitutes...
  46. ncbi Stimulation of neo-angiogenesis by combined use of irradiated and vascularized living bone graft for oncological reconstruction
    Keiichi Muramatsu
    Department of Orthopedic Surgery, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Surg Oncol 21:223-9. 2012
    ..The rationale for a combined vascularized and irradiated bone autograft is the cumulative advantage provided by the biological properties of the former with the mechanical endurance of the latter...
  47. ncbi The indications and use of bone morphogenetic proteins in foot, ankle, and tibia surgery
    Saadiq F El-Amin
    Division of Orthopaedic Surgery, Southern Illinois University School of Medicine, PO Box 19679, Springfield, IL 62794 9620, USA
    Foot Ankle Clin 15:543-51. 2010
    ..Future applications of BMP and novel materials in foot and ankle surgery are also reviewed...
  48. ncbi Rehabilitation of atrophic maxilla using the combination of autogenous and allogeneic bone grafts followed by protocol-type prosthesis
    Rogerio Margonar
    Discipline of Implantology, University Center of Barretos, UNESP Sao Paulo State University, Aracatuba, Sao Paulo, Brazil
    J Craniofac Surg 21:1894-6. 2010
    ....
  49. ncbi Retrieved human allografts : a clinicopathological study
    W F Enneking
    Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville 32610-0246, USA
    J Bone Joint Surg Am 83:971-86. 2001
    ....
  50. ncbi Use of the reamer-irrigator-aspirator technique to obtain autograft for ankle and hindfoot arthrodesis
    D Herscovici
    Florida Orthopaedic Institute, Foot and Ankle Service, 13020 Telecom Parkway, Temple Terrace, Florida 33637, USA
    J Bone Joint Surg Br 94:75-9. 2012
    ..This is an efficient method of obtaining autologous bone for use in arthrodesis of the ankle or hindfoot...
  51. ncbi Acetabular reconstruction with impaction bone-grafting and a cemented cup in patients younger than fifty years old: a concise follow-up, at twenty to twenty-eight years, of a previous report
    Vincent J J F Busch
    Department of Orthopaedics 357, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Bone Joint Surg Am 93:367-71. 2011
    ....
  52. ncbi In vivo performance of bilayer hydroxyapatite scaffolds for bone tissue regeneration in the rabbit radius
    Teja Guda
    Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Fort Sam Houston, TX 78234, USA
    J Mater Sci Mater Med 22:647-56. 2011
    ....
  53. ncbi Comparison of six bone-graft substitutes regarding to cell seeding efficiency, metabolism and growth behaviour of human mesenchymal stem cells (MSC) in vitro
    Caroline Seebach
    Department of Trauma Surgery, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Injury 41:731-8. 2010
    ..g. MSC) and using the correct scaffold incorporated into a local environment for bone regeneration. The need for an unlimited supply with high quality bone-graft substitutes continue to find alternatives for bone replacement surgery...
  54. ncbi Safety and effectiveness of bone allografts in anterior cervical discectomy and fusion surgery
    Larry E Miller
    Miller Scientific Consulting, Inc, Biltmore Lake, NC, USA
    Spine (Phila Pa 1976) 36:2045-50. 2011
    ..Systematic review...
  55. ncbi Fibrous dysplasia. Pathophysiology, evaluation, and treatment
    Matthew R Dicaprio
    Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville 32608, USA
    J Bone Joint Surg Am 87:1848-64. 2005
    ..The use of cortical grafts is preferred over cancellous grafts or bone-graft substitutes because of the superior physical qualities of remodeled cortical bone...
  56. pmc Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study
    Nina M C Mathijssen
    Netherlands Bone Bank Foundation, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands
    BMC Musculoskelet Disord 11:96. 2010
    ..In addition, while it would be desirable to add the antibiotics to allograft bone chips before these are stored in a bone bank, the effects of different storage temperatures on antibiotics are unknown...
  57. ncbi The effect of pretreating morselized allograft bone with rhBMP-2 and/or pamidronate on the fixation of porous Ti and HA-coated implants
    Jorgen Baas
    Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Building 1A, 8000 Aarhus C, Denmark
    Biomaterials 29:2915-22. 2008
    ..Pamidronate virtually blocked bone metabolism, also when combined with rhBMP-2. The results warrant a conservative approach and emphasize the importance of identifying a therapeutic window for these substances prior to clinical use...
  58. ncbi Effect of low dose and moderate dose gamma irradiation on the mechanical properties of bone and soft tissue allografts
    Colleen R Balsly
    Research and Development, LifeNet Health, 1864 Concert Drive, Virginia Beach, VA 23453, USA
    Cell Tissue Bank 9:289-98. 2008
    ..The results of this study support the use of low dose and moderate dose gamma irradiation of bone grafts. For soft tissue grafts, the results support the use of low dose irradiation...
  59. pmc Mid-term results of acetabular reconstruction using a Kerboull-type acetabular reinforcement device
    Junji Hori
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima City 734 8551, Japan
    Int Orthop 36:23-6. 2012
    ..The purpose of this study was to investigate the mid-term results of 32 acetabular reconstructions performed using a Kerboull-type acetabular reinforcement device and bone graft between June 1997 and January 2009...
  60. ncbi Microstimulation at the bone-implant interface upregulates osteoclast activation pathways
    Vincent A Stadelmann
    Laboratory of Biomechanical Orthopedics EPFL HOSR, Institute of Translational Biomechanics, Station 15, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Bone 42:358-64. 2008
    ..This suggests that the micromotions arising at the bone-implant interface during normal gait cycles induce a bone resorption response after only 1 h, which occurs before any wear debris particles enter the system...
  61. ncbi Impaction bone-grafting in revision joint replacement surgery
    Andrew D Toms
    J Bone Joint Surg Am 86:2050-60. 2004
    ..The use of compacted morselized bone graft is a relatively new technique in revision knee surgery and requires longer-term follow-up with larger numbers of patients to assess its value...
  62. pmc In vivo comparison of the bone regeneration capability of human bone marrow concentrates vs. platelet-rich plasma
    Weijian Zhong
    Department of Regenerative Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    PLoS ONE 7:e40833. 2012
    ..The objective of this study was to evaluate the effects of human BMAC and PRP in combination with β-tricalcium phosphate (β-TCP) on promoting initial bone augmentation in an immunodeficient mouse model...
  63. pmc Engineering anatomically shaped human bone grafts
    Warren L Grayson
    Department of Biomedical Engineering, Columbia University, VC 12 234, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:3299-304. 2010
    ..This approach has potential to overcome a critical hurdle-in vitro cultivation of viable bone grafts of complex geometries-to provide patient-specific bone grafts for craniofacial and orthopedic reconstructions...
  64. ncbi Prospective, randomized, multi-center feasibility trial of rhPDGF-BB versus autologous bone graft in a foot and ankle fusion model
    Christopher W DiGiovanni
    University Orthopaedics, Inc, 100 Butler Dr, Providence, RI 02906, USA
    Foot Ankle Int 32:344-54. 2011
    ....
  65. pmc Revisions of extensive acetabular defects with impaction grafting and a cement cup
    Nienke van Egmond
    Department of Orthopaedics 357, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Orthop Relat Res 469:562-73. 2011
    ..Loosening of acetabular components often leads to bony defects. Management of extensive acetabular bone loss in hip revision arthroplasty can be a tremendous challenge...
  66. ncbi Platelet-rich plasma in sinus augmentation procedures: a systematic literature review: Part II
    Navneet S Arora
    Division of Periodontology, Eastman Dental Center, Rochester, NY 14620, USA
    Implant Dent 19:145-57. 2010
    ..Therefore, it can be rightly stated that evidence for an adjunctive benefit of using PRP with bone grafts in sinus augmentation procedures is equivocal and inconclusive...
  67. pmc Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: a bone chamber study in rats
    Ola Belfrage
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Sweden
    Acta Orthop 82:228-33. 2011
    ..Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combination of both drugs as a local admix to a cancellous allograft...
  68. pmc The threshold force required for femoral impaction grafting in revision hip surgery
    Olivia M Flannery
    Trinity Centre for Bioengineering, School of Engineering, Trinity College, Dublin, Ireland
    Acta Orthop 81:303-7. 2010
    ..Femoral impaction grafting requires vigorous impaction to obtain adequate stability without risk of fracture, but the force of impaction has not been determined. We determined this threshold force in a preliminary study using animal femurs...
  69. ncbi Surgical techniques: how I do it? The Reamer/Irrigator/Aspirator (RIA) system
    P V Giannoudis
    Department of Trauma and Orthopaedics, Academic Unit, Clarendon Wing, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    Injury 40:1231-6. 2009
    ..We present our current approach to the use of the RIA system, including the preoperative planning, the details of the operative procedure, the pitfalls and the potential complications that could be encountered...
  70. ncbi The concept of induced membrane for reconstruction of long bone defects
    Alain C Masquelet
    Department of Orthopedic and Traumatology, Avicenne Hospital, Medical University of Paris, 125, route de Stalingrad, 93009 Bobigny, Paris, France
    Orthop Clin North Am 41:27-37; table of contents. 2010
    ..The induced membrane appears as a biological chamber, which allows the conception of numerous experimental models of bone reconstruction. This concept could probably be extended to other tissue repair...
  71. ncbi Revision total hip replacement using the Kerboull acetabular reinforcement device with morsellised or bulk graft: results at a mean follow-up of 8.7 years
    K Kawanabe
    Department of Orthopaedic Surgery, Faculty of Medicine Kyoto University, Kyoto, Japan
    J Bone Joint Surg Br 89:26-31. 2007
    ..5% to 63.5%) and 82% (95% CI 72.4% to 91.6%), respectively. The mid-term results of revision total hip replacement with the Kerboull device were better when bulk graft was used in any size of bone defect...
  72. ncbi Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs
    Simon Storgård Jensen
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Bern, Switzerland
    Clin Oral Implants Res 17:237-43. 2006
    ..The purpose was to qualitatively and quantitatively compare the bone formation and graft resorption of two different bone substitutes used in both orthopedic and oral surgery, with autogenous bone as a positive control...
  73. ncbi Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity
    Ma amon A Rawashdeh
    Department Oral and Maxillofacial Surgery, Jordan University of Science and Technology, Jordan
    Br J Oral Maxillofac Surg 46:665-70. 2008
    ..Much more research and development are necessary to find a suitable carrier for rhBMP-2, and to study the properties of newly formed bone that it has induced before it can be a substitute for autogenous bone...
  74. ncbi Femoral impaction bone grafting with the Exeter stem - the Swedish experience: survivorship analysis of 1305 revisions performed between 1989 and 2002
    E Ornstein
    Department of Orthopaedic Surgery, Hassleholm Hospital, SE 28125, Hassleholm, Sweden
    J Bone Joint Surg Br 91:441-6. 2009
    ..The technique of impaction grafting appears to be reliable, can be learned rapidly and produces a predictably low incidence of aseptic loosening...
  75. ncbi Small free vascularized iliac crest bone grafts in reconstruction of the scaphoid bone: a retrospective study in 60 cases
    C Harpf
    University Clinic for Plastic and Reconstructive Surgery, the University Clinic for Traumatology, University of Innsbruck, Austria
    Plast Reconstr Surg 108:664-74. 2001
    ..Reconstruction of the scaphoid by means of implantation of a vascularized iliac bone graft proved efficient to treat avascular recalcitrant scaphoid nonunion and pseudarthrosis with avascular proximal pole fragments...
  76. ncbi Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial
    Alan L Jones
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Bone Joint Surg Am 88:1431-41. 2006
    ....
  77. ncbi Mechanics of interbody spinal fusion. Analysis of critical bone graft area
    R F Closkey
    Robert Wood Johnson Medical School, New Brunswick, New Jersey
    Spine (Phila Pa 1976) 18:1011-5. 1993
    ..abstract truncated at 250 words)..
  78. ncbi Management of chondroblastoma: retrospective review of 28 patients
    Hakan Atalar
    Department of Orthopaedic Surgery and Traumatology, Fatih University, Alparslan Turkes Caddesi No 57, 06510, Emek, Ankara, Turkey
    J Orthop Sci 12:334-40. 2007
    ..This study retrospectively reviewed 28 patients who presented with chondroblastoma in our hospital during the period March 1986 to February 2006. We investigated factors associated with local recurrence of the tumors after surgery...
  79. ncbi Morbidity associated with anterior iliac crest bone grafting in foot and ankle surgery
    James K DeOrio
    Mayo Clinic, Department of Orthopaedic Surgery, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Foot Ankle Int 26:147-51. 2005
    ..We reviewed our patients' morbidity after harvest of anterior iliac crest bone grafts for procedures involving the foot and ankle...
  80. pmc Bone defects following curettage do not necessarily need augmentation
    Martti Hirn
    The Oncology Unit, Royal Orthopaedic Hospital, Birmingham, UK
    Acta Orthop 80:4-8. 2009
    ..The natural pattern of bone healing in large bony defects following curettage alone as treatment of benign bone tumors around the knee is not well reported. We analyzed the outcome in 146 patients...
  81. ncbi Engineering new bone tissue in vitro on highly porous poly(alpha-hydroxyl acids)/hydroxyapatite composite scaffolds
    P X Ma
    Department of Biologic and Materials Sciences, 1011 North University Ave, Room 2211, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biomed Mater Res 54:284-93. 2001
    ..These results demonstrate that HAP imparts osteoconductivity and the highly porous PLLA/HAP composite scaffolds are superior to pure PLLA scaffolds for bone tissue engineering...
  82. ncbi Mandibular reconstruction in adults: a review
    Bee Tin Goh
    Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore
    Int J Oral Maxillofac Surg 37:597-605. 2008
    ..Refinements in techniques continue to improve patient quality of life. This paper reviews current techniques of mandibular reconstruction in adults and discusses the strengths and weaknesses of each...
  83. ncbi The transmission of stress to grafted bone inside a titanium mesh cage used in anterior column reconstruction after total spondylectomy: a finite-element analysis
    Tomoyuki Akamaru
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    Spine (Phila Pa 1976) 30:2783-7. 2005
    ..A finite-element study of posterior alone or anterior/posterior combined instrumentation following total spondylectomy and replacement with a titanium mesh cage used as an anterior strut...
  84. ncbi A prospective consecutive study of instrumented posterolateral lumbar fusion using synthetic hydroxyapatite (Bongros-HA) as a bone graft extender
    Jae Hyup Lee
    Department of Orthopedic Surgery, College of Medicine, Seoul National University, Seoul Metropolitan Boramae Hospital, Seoul 156 707, Korea
    J Biomed Mater Res A 90:804-10. 2009
    ..This study suggests that hydroxyapatite bone chips could be used usefully as a bone-graft extender in short-segment posterolateral spinal fusion...
  85. ncbi Role of conventional and vascularized bone grafts in scaphoid nonunion with avascular necrosis: A canine experimental study
    T Sunagawa
    Microvascular Research Laboratory, Department of Orthopedic Surgery, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Hand Surg Am 25:849-59. 2000
    ..These experimental data support the potential clinical application of pedicled reverse-flow vascularized grafts in the treatment of carpal fracture nonunions with avascular necrosis, including proximal pole scaphoid nonunions...
  86. ncbi Persistent iliac crest donor site pain: independent outcome assessment
    Robert F Heary
    Department of Neurosurgery, Neurological Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Neurosurgery 50:510-6; discussion 516-7. 2002
    ..In addition, this study identifies the significant discrepancies that are observed when independent outcome assessment results are compared with the incidences determined by review of the operating surgeon's documented findings...
  87. pmc Treatment of nontraumatic osteonecrosis of the femoral head using bone impaction grafting through a femoral neck window
    Bai Liang Wang
    Osteonecrosis and Joint Preserving and Reconstruction Center, Department of Orthopaedic Surgery, China Japan Friendship Hospital, Beijing 100029, China
    Int Orthop 34:635-9. 2010
    ..Therefore, it may be the treatment of choice particularly in nontraumatic osteonecrosis of the femoral head of pre-collapse stage with small and middle area (<30%, or the depth of collapse <2 mm)...
  88. ncbi Overview of biologics
    J Tracy Watson
    Department of Orthopaedic Surgery, St Louis University School of Medicine, St Louis, Mo 63110 0250, USA
    J Orthop Trauma 19:S14-6. 2005
    ....
  89. ncbi Changes in subchondral bone in cartilage resurfacing--an experimental study in sheep using different types of osteochondral grafts
    B von Rechenberg
    Musculoskeletal Research Unit, Department of Equine Sciences, University of Zurich, Winterhurerstrasse 260, 8057, Zurich, Switzerland
    Osteoarthritis Cartilage 11:265-77. 2003
    ..Photooxidation was expected to improve mechanical stability of the osteochondral grafts through an improved linkage of the collagen fibers within the bone matrix...
  90. ncbi An overview of the histology of skeletal substitute materials
    Thomas W Bauer
    Department of Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44106, USA
    Arch Pathol Lab Med 131:217-24. 2007
    ..The amount of autograft is limited, and conventional allograft has some disadvantages, so surgeons are now using increasing amounts of demineralized allograft and a variety of synthetic materials to replace or "extend" autograft...
  91. ncbi Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment
    Joerg Wiltfang
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 15:187-93. 2004
    ..An animal study was carried out to investigate the influence of platelet-rich plasma (PRP) on the regeneration of bony defects...
  92. ncbi Maxillary sinus and ridge augmentations using a surface-derived autogenous bone graft
    Michael Peleg
    Department of Surgery, Division of Oral Maxillofacial Surgery, University of Miami School of Medicine, FL 33136, USA
    J Oral Maxillofac Surg 62:1535-44. 2004
    ..A handheld instrument is described that cuts and collects thin shavings of bone from cortical surfaces...
  93. ncbi The impact of irradiation on the microbiological safety, biomechanical properties, and clinical performance of musculoskeletal allografts
    Jon E Block
    Orthopedics 29:991-6; quiz 997-8. 2006
  94. ncbi Alendronate prevents collapse in mechanically loaded osteochondral grafts: a bone chamber study in rats
    Magnus Tagil
    Departments of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Acta Orthop Scand 75:756-61. 2004
    ..To investigate this, we used a rat bone chamber model to subject a necrotic osteochondral graft to a large mechanical load during remodeling...
  95. ncbi Cancellous impaction grafting in the human femur: histological and radiographic observations in 6 autopsy femurs and 8 biopsies
    L Linder
    Department of Orthopedics, Gavle Hospital, Sweden
    Acta Orthop Scand 71:543-52. 2000
    ..Radiographic criteria used to assess primary total joint replacement do not necessarily apply to impaction grafting, and radiographic changes should be interpreted cautiously, especially as regards tissue viability...
  96. ncbi Treatment of severe atrophy of the maxilla with the prefabricated free vascularized fibula flap
    Dennis Rohner
    Department of Reconstructive Surgery, University of Basel, University Hospital, Switzerland
    Clin Oral Implants Res 13:44-52. 2002
    ..The reconstructions with the fibula flaps were successful and the 18 ITI implants that have been inserted showed good osseointegration without loss of attachment in all 4 patients after a mean observation period of 12 months...
  97. ncbi Effect of gamma irradiation on human cortical bone transplants contaminated with enveloped and non-enveloped viruses
    Axel Pruss
    Institute for Transfusion Medicine, Tissue Bank, University Hospital Charite, Medical Faculty of the Humboldt University Berlin, Berlin, Germany
    Biologicals 30:125-33. 2002
    ..We therefore recommend a dose of 34 kGy for the sterilisation of frozen bone transplants...
  98. pmc Treatment of osteochondral lesions of the talus: a systematic review
    Maartje Zengerink
    Department of Orthopaedic Surgery, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 18:238-46. 2010
    ..Further sufficiently powered, randomized clinical trials with uniform methodology and validated outcome measures should be initiated to compare the outcome of surgical strategies for OCD of the talus...
  99. ncbi The use of photooxidized, mushroom-structured osteochondral grafts for cartilage resurfacing--a comparison to photooxidized cylindrical grafts in an experimental study in sheep
    B von Rechenberg
    Musculoskeletal Research Unit, Equine Hospital, Faculty of Veterinary Medicine, University of Zurich, Zurich, Switzerland
    Osteoarthritis Cartilage 12:201-16. 2004
    ..This article addresses the problem of structural design with osteochondral grafts used for cartilage resurfacing...
  100. ncbi Influence of low-level laser treatment on bone regeneration and osseointegration of dental implants following sinus augmentation. An experimental study on sheep
    Norbert Jakse
    Department of Oral Surgery and Radiology, School of Dentistry, Medical University Graz, Graz, Austria
    Clin Oral Implants Res 18:517-24. 2007
    ..The aim of this experimental study was to evaluate if low-level laser treatment (LLLT) enhances bone regeneration and osseointegration of dental implants in a sinus graft model...
  101. pmc Comparative study of laparoscopic L5-S1 fusion versus open mini-ALIF, with a minimum 2-year follow-up
    Sang Ki Chung
    Department of Neurosurgery and General Surgery, Wooridul Spine Hospital, 47 4 Chungdam dong Kangnam gu, 135 100 Seoul, Korea
    Eur Spine J 12:613-7. 2003
    ..The fusion rate was 91% in both groups. The laparoscopic ALIF for L5-S1 showed similar clinical and radiological outcome when compared with open mini-ALIF, but significant advantages were not identified, despite its technical difficulty...

Research Grants23

  1. Adult Stem Cells: Osteoblast Differentiation and Engraftment
    David W Rowe; Fiscal Year: 2011
    ..This grant will provide a head to head comparison of the osteoprogenitor potential for bone transplantation of cells from 5 different tissues...
  2. ENDOCHONDRAL BONE FORMATION IN RENAL FAILURE
    ISIDRO SALUSKY; Fiscal Year: 1999
    ..The specific aims of the current application are: 1) to utilize an established model of neonatal bone transplantation into adult murine recipients to characterize the effect of renal failure on chondrocyte differentiation and ..
  3. Biodegradable Scaffolds for Periodontal Void-Filling
    DEBRA TRANTOLO; Fiscal Year: 2001
    ..Although autograft is the gold standard of bone transplantation, the results of autograft reconstruction in periodontal ridge reconstruction are sometimes unpredictable ..
  4. STRUCTURE AND METABOLISM OF VASCULARIZED ALLOGRAFTS
    Victor Goldberg; Fiscal Year: 1993
    ..New additional analytical methodologies will further extend our understanding of bone transplantation biology...
  5. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  6. Prospective evaluation of immediate temporized implants
    Michael Block; Fiscal Year: 2007
    ..Standardized hard and soft tissue data will be collected preextraction as baseline, and then prospectively for at least two years in this trial, to compare and contrast the methods. ..
  7. Protein Biomarkers in Lung Allograft Rejection
    CHRIS H WENDT; Fiscal Year: 2010
    ..The second is to increase the number of biomarkers for chronic rejection, creating a panel of protein biomarkers that ultimately predicts those with or are at risk for chronic lung transplant rejection. ..
  8. Na, K-ATPase Regulation by Glucocorticoids in Lung
    Chris Wendt; Fiscal Year: 2007
    ....
  9. NONLINEAR STRESS-STRAIN BEHAVIOR OF CORTICAL BONE
    DWIGHT DAVY; Fiscal Year: 2004
    ....
  10. Functional Health CAT in Diabetes
    Carolyn Schwartz; Fiscal Year: 2004
    ..abstract_text> ..
  11. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..
  12. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  13. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  14. Cellular Contribution to Bone Healing
    Celine Colnot; Fiscal Year: 2006
    ..abstract_text> ..
  15. Gene Transfer of Hematopoietic Stem Cells
    Christopher Walsh; Fiscal Year: 2004
    ..Information obtained from the planned studies will provide a better understanding of abnormal hematopoiesis in FA and better define therapeutic strategies important for designing future human clinical trials. ..
  16. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
    ..4. Image the three-dimensional damage developed in cortical bone specimens following low cycle fatigue in four point bending. Differences in damage patterns due to pure bending and combined bending and shear loading will be identified. ..
  18. Angiogenesis & Osteogenesis in Structural Graft Healing
    Xinping Zhang; Fiscal Year: 2007
    ..abstract_text> ..
  19. Gene Therapy for the Hemophilias
    Christopher Walsh; Fiscal Year: 2006
    ..Each method will be optimized and in AAV vectors for FVIII production and tested in vivo using immunodeficient and FVIII knockout mice and hemophilic A canines. ..
  20. Rabbit Model for In Vivo Monitoring of Bone Structure
    Michael Voor; Fiscal Year: 2003
    ..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
  21. Dental Implant Science & Tech Transfer Satellite Meeting
    Jack Lemons; Fiscal Year: 2004
    ..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
  22. Analyses of InSitu and Explanted Surgical Implant Devices
    Jack Lemons; Fiscal Year: 2009
    ..abstract_text> ..