bone transplantation

Summary

Summary: The grafting of bone from a donor site to a recipient site.

Top Publications

  1. ncbi Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    J C Banwart
    Section of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, USA
    Spine (Phila Pa 1976) 20:1055-60. 1995
  2. ncbi Bone tissue engineering: state of the art and future trends
    Antonio J Salgado
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Macromol Biosci 4:743-65. 2004
  3. doi Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review
    Rozalia Dimitriou
    Department of Trauma and Orthopaedic Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Injury 42:S3-15. 2011
  4. doi Tissue engineering of bone: material and matrix considerations
    Yusuf Khan
    University of Virginia School of Medicine, 400 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:36-42. 2008
  5. ncbi Effects of hydrogen peroxide cleaning procedures on bone graft osteoinductivity and mechanical properties
    C A DePaula
    Musculoskeletal Transplant Foundation, Edison, NJ 08837, USA
    Cell Tissue Bank 6:287-98. 2005
  6. ncbi Fractures through bone cysts: unicameral bone cysts, aneurysmal bone cysts, fibrous cortical defects, and nonossifying fibromas
    John P Dormans
    Children s Hospital of Philadelphia, Division of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Instr Course Lect 51:457-67. 2002
  7. pmc The effect of soaking allograft in bisphosphonate: a pilot dose-response study
    Thomas Jakobsen
    Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    Clin Orthop Relat Res 468:867-74. 2010
  8. ncbi Reconstruction of the mandible with osseous free flaps: a 10-year experience with 150 consecutive patients
    P G Cordeiro
    Plastic and Reconstructive Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 104:1314-20. 1999
  9. ncbi Alveolar cleft osteoplasty using tissue-engineered osteogenic material
    H Hibi
    Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Int J Oral Maxillofac Surg 35:551-5. 2006
  10. ncbi Effects of ionizing radiation on the mechanical properties of human bone
    J D Currey
    Department of Biology, University of York, England, U K
    J Orthop Res 15:111-7. 1997

Detail Information

Publications242 found, 100 shown here

  1. ncbi Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    J C Banwart
    Section of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, USA
    Spine (Phila Pa 1976) 20:1055-60. 1995
    ..The findings suggest that procedural refinements of limiting subcutaneous dissection and providing layered tension-free incision closure may improve results...
  2. ncbi Bone tissue engineering: state of the art and future trends
    Antonio J Salgado
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Macromol Biosci 4:743-65. 2004
    ..Scaffolds processed by using a methodology based on extrusion with blowing agents...
  3. doi Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review
    Rozalia Dimitriou
    Department of Trauma and Orthopaedic Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Injury 42:S3-15. 2011
    ....
  4. doi Tissue engineering of bone: material and matrix considerations
    Yusuf Khan
    University of Virginia School of Medicine, 400 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:36-42. 2008
    ....
  5. ncbi Effects of hydrogen peroxide cleaning procedures on bone graft osteoinductivity and mechanical properties
    C A DePaula
    Musculoskeletal Transplant Foundation, Edison, NJ 08837, USA
    Cell Tissue Bank 6:287-98. 2005
    ..The improved cleaning procedure therefore did not compromise the strength or osteoinductivity of cortical bone allografts in comparison to the standard procedure...
  6. ncbi Fractures through bone cysts: unicameral bone cysts, aneurysmal bone cysts, fibrous cortical defects, and nonossifying fibromas
    John P Dormans
    Children s Hospital of Philadelphia, Division of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Instr Course Lect 51:457-67. 2002
  7. pmc The effect of soaking allograft in bisphosphonate: a pilot dose-response study
    Thomas Jakobsen
    Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    Clin Orthop Relat Res 468:867-74. 2010
    ..Long-term survival of uncemented total joint replacements relies on osseointegration. With reduced bone stock impacted morselized allograft enhances early implant fixation but is subject to resorption...
  8. ncbi Reconstruction of the mandible with osseous free flaps: a 10-year experience with 150 consecutive patients
    P G Cordeiro
    Plastic and Reconstructive Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 104:1314-20. 1999
    ..The ilium is recommended only when other options are unavailable. Thoughtful flap selection and design should supplant the need for multiple, simultaneous free flaps and vein grafting in most cases...
  9. ncbi Alveolar cleft osteoplasty using tissue-engineered osteogenic material
    H Hibi
    Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Int J Oral Maxillofac Surg 35:551-5. 2006
    ..1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge...
  10. ncbi Effects of ionizing radiation on the mechanical properties of human bone
    J D Currey
    Department of Biology, University of York, England, U K
    J Orthop Res 15:111-7. 1997
    ....
  11. pmc Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study
    Nina M C Mathijssen
    Netherlands Bone Bank Foundation, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands
    BMC Musculoskelet Disord 11:96. 2010
    ..In addition, while it would be desirable to add the antibiotics to allograft bone chips before these are stored in a bone bank, the effects of different storage temperatures on antibiotics are unknown...
  12. doi Comparison of six bone-graft substitutes regarding to cell seeding efficiency, metabolism and growth behaviour of human mesenchymal stem cells (MSC) in vitro
    Caroline Seebach
    Department of Trauma Surgery, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Injury 41:731-8. 2010
    ..g. MSC) and using the correct scaffold incorporated into a local environment for bone regeneration. The need for an unlimited supply with high quality bone-graft substitutes continue to find alternatives for bone replacement surgery...
  13. doi Safety and effectiveness of bone allografts in anterior cervical discectomy and fusion surgery
    Larry E Miller
    Miller Scientific Consulting, Inc, Biltmore Lake, NC, USA
    Spine (Phila Pa 1976) 36:2045-50. 2011
    ..Systematic review...
  14. ncbi Fibrous dysplasia. Pathophysiology, evaluation, and treatment
    Matthew R Dicaprio
    Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville 32608, USA
    J Bone Joint Surg Am 87:1848-64. 2005
    ..The use of cortical grafts is preferred over cancellous grafts or bone-graft substitutes because of the superior physical qualities of remodeled cortical bone...
  15. ncbi Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial
    Alan L Jones
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Bone Joint Surg Am 88:1431-41. 2006
    ....
  16. doi Platelet-rich plasma in sinus augmentation procedures: a systematic literature review: Part II
    Navneet S Arora
    Division of Periodontology, Eastman Dental Center, Rochester, NY 14620, USA
    Implant Dent 19:145-57. 2010
    ..Therefore, it can be rightly stated that evidence for an adjunctive benefit of using PRP with bone grafts in sinus augmentation procedures is equivocal and inconclusive...
  17. doi The effect of pretreating morselized allograft bone with rhBMP-2 and/or pamidronate on the fixation of porous Ti and HA-coated implants
    Jorgen Baas
    Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Building 1A, 8000 Aarhus C, Denmark
    Biomaterials 29:2915-22. 2008
    ..Pamidronate virtually blocked bone metabolism, also when combined with rhBMP-2. The results warrant a conservative approach and emphasize the importance of identifying a therapeutic window for these substances prior to clinical use...
  18. pmc Engineering anatomically shaped human bone grafts
    Warren L Grayson
    Department of Biomedical Engineering, Columbia University, VC 12 234, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:3299-304. 2010
    ..This approach has potential to overcome a critical hurdle-in vitro cultivation of viable bone grafts of complex geometries-to provide patient-specific bone grafts for craniofacial and orthopedic reconstructions...
  19. pmc In vivo comparison of the bone regeneration capability of human bone marrow concentrates vs. platelet-rich plasma
    Weijian Zhong
    Department of Regenerative Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    PLoS ONE 7:e40833. 2012
    ..The objective of this study was to evaluate the effects of human BMAC and PRP in combination with β-tricalcium phosphate (β-TCP) on promoting initial bone augmentation in an immunodeficient mouse model...
  20. doi Effect of low dose and moderate dose gamma irradiation on the mechanical properties of bone and soft tissue allografts
    Colleen R Balsly
    Research and Development, LifeNet Health, 1864 Concert Drive, Virginia Beach, VA 23453, USA
    Cell Tissue Bank 9:289-98. 2008
    ..The results of this study support the use of low dose and moderate dose gamma irradiation of bone grafts. For soft tissue grafts, the results support the use of low dose irradiation...
  21. ncbi Microstimulation at the bone-implant interface upregulates osteoclast activation pathways
    Vincent A Stadelmann
    Laboratory of Biomechanical Orthopedics EPFL HOSR, Institute of Translational Biomechanics, Station 15, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Bone 42:358-64. 2008
    ..This suggests that the micromotions arising at the bone-implant interface during normal gait cycles induce a bone resorption response after only 1 h, which occurs before any wear debris particles enter the system...
  22. ncbi Impaction bone-grafting in revision joint replacement surgery
    Andrew D Toms
    J Bone Joint Surg Am 86:2050-60. 2004
    ..The use of compacted morselized bone graft is a relatively new technique in revision knee surgery and requires longer-term follow-up with larger numbers of patients to assess its value...
  23. pmc Mid-term results of acetabular reconstruction using a Kerboull-type acetabular reinforcement device
    Junji Hori
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima City 734 8551, Japan
    Int Orthop 36:23-6. 2012
    ..The purpose of this study was to investigate the mid-term results of 32 acetabular reconstructions performed using a Kerboull-type acetabular reinforcement device and bone graft between June 1997 and January 2009...
  24. pmc Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: a bone chamber study in rats
    Ola Belfrage
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Sweden
    Acta Orthop 82:228-33. 2011
    ..Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combination of both drugs as a local admix to a cancellous allograft...
  25. pmc Revisions of extensive acetabular defects with impaction grafting and a cement cup
    Nienke van Egmond
    Department of Orthopaedics 357, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Orthop Relat Res 469:562-73. 2011
    ..Loosening of acetabular components often leads to bony defects. Management of extensive acetabular bone loss in hip revision arthroplasty can be a tremendous challenge...
  26. doi Prospective, randomized, multi-center feasibility trial of rhPDGF-BB versus autologous bone graft in a foot and ankle fusion model
    Christopher W DiGiovanni
    University Orthopaedics, Inc, 100 Butler Dr, Providence, RI 02906, USA
    Foot Ankle Int 32:344-54. 2011
    ....
  27. doi Femoral impaction bone grafting with the Exeter stem - the Swedish experience: survivorship analysis of 1305 revisions performed between 1989 and 2002
    E Ornstein
    Department of Orthopaedic Surgery, Hassleholm Hospital, SE 28125, Hassleholm, Sweden
    J Bone Joint Surg Br 91:441-6. 2009
    ..The technique of impaction grafting appears to be reliable, can be learned rapidly and produces a predictably low incidence of aseptic loosening...
  28. doi The concept of induced membrane for reconstruction of long bone defects
    Alain C Masquelet
    Department of Orthopedic and Traumatology, Avicenne Hospital, Medical University of Paris, 125, route de Stalingrad, 93009 Bobigny, Paris, France
    Orthop Clin North Am 41:27-37; table of contents. 2010
    ..The induced membrane appears as a biological chamber, which allows the conception of numerous experimental models of bone reconstruction. This concept could probably be extended to other tissue repair...
  29. doi Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects
    Marcus Jager
    Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Orthop Res 29:173-80. 2011
    ..BMAC combined with HA can reduce the time needed for healing of bone defects when compared to BMAC in combination with collagen sponge...
  30. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008
    ..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone defects...
  31. doi Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity
    Ma amon A Rawashdeh
    Department Oral and Maxillofacial Surgery, Jordan University of Science and Technology, Jordan
    Br J Oral Maxillofac Surg 46:665-70. 2008
    ..Much more research and development are necessary to find a suitable carrier for rhBMP-2, and to study the properties of newly formed bone that it has induced before it can be a substitute for autogenous bone...
  32. doi Surgical techniques: how I do it? The Reamer/Irrigator/Aspirator (RIA) system
    P V Giannoudis
    Department of Trauma and Orthopaedics, Academic Unit, Clarendon Wing, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    Injury 40:1231-6. 2009
    ..We present our current approach to the use of the RIA system, including the preoperative planning, the details of the operative procedure, the pitfalls and the potential complications that could be encountered...
  33. pmc The threshold force required for femoral impaction grafting in revision hip surgery
    Olivia M Flannery
    Trinity Centre for Bioengineering, School of Engineering, Trinity College, Dublin, Ireland
    Acta Orthop 81:303-7. 2010
    ..Femoral impaction grafting requires vigorous impaction to obtain adequate stability without risk of fracture, but the force of impaction has not been determined. We determined this threshold force in a preliminary study using animal femurs...
  34. ncbi Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs
    Simon Storgård Jensen
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Bern, Switzerland
    Clin Oral Implants Res 17:237-43. 2006
    ..The purpose was to qualitatively and quantitatively compare the bone formation and graft resorption of two different bone substitutes used in both orthopedic and oral surgery, with autogenous bone as a positive control...
  35. ncbi Revision total hip replacement using the Kerboull acetabular reinforcement device with morsellised or bulk graft: results at a mean follow-up of 8.7 years
    K Kawanabe
    Department of Orthopaedic Surgery, Faculty of Medicine Kyoto University, Kyoto, Japan
    J Bone Joint Surg Br 89:26-31. 2007
    ..5% to 63.5%) and 82% (95% CI 72.4% to 91.6%), respectively. The mid-term results of revision total hip replacement with the Kerboull device were better when bulk graft was used in any size of bone defect...
  36. ncbi Maxillary sinus and ridge augmentations using a surface-derived autogenous bone graft
    Michael Peleg
    Department of Surgery, Division of Oral Maxillofacial Surgery, University of Miami School of Medicine, FL 33136, USA
    J Oral Maxillofac Surg 62:1535-44. 2004
    ..A handheld instrument is described that cuts and collects thin shavings of bone from cortical surfaces...
  37. ncbi An overview of the histology of skeletal substitute materials
    Thomas W Bauer
    Department of Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44106, USA
    Arch Pathol Lab Med 131:217-24. 2007
    ..The amount of autograft is limited, and conventional allograft has some disadvantages, so surgeons are now using increasing amounts of demineralized allograft and a variety of synthetic materials to replace or "extend" autograft...
  38. ncbi Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment
    Joerg Wiltfang
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 15:187-93. 2004
    ..An animal study was carried out to investigate the influence of platelet-rich plasma (PRP) on the regeneration of bony defects...
  39. ncbi The use of photooxidized, mushroom-structured osteochondral grafts for cartilage resurfacing--a comparison to photooxidized cylindrical grafts in an experimental study in sheep
    B von Rechenberg
    Musculoskeletal Research Unit, Equine Hospital, Faculty of Veterinary Medicine, University of Zurich, Zurich, Switzerland
    Osteoarthritis Cartilage 12:201-16. 2004
    ..This article addresses the problem of structural design with osteochondral grafts used for cartilage resurfacing...
  40. ncbi The impact of irradiation on the microbiological safety, biomechanical properties, and clinical performance of musculoskeletal allografts
    Jon E Block
    Orthopedics 29:991-6; quiz 997-8. 2006
  41. ncbi Alendronate prevents collapse in mechanically loaded osteochondral grafts: a bone chamber study in rats
    Magnus Tagil
    Departments of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Acta Orthop Scand 75:756-61. 2004
    ..To investigate this, we used a rat bone chamber model to subject a necrotic osteochondral graft to a large mechanical load during remodeling...
  42. pmc Treatment of osteochondral lesions of the talus: a systematic review
    Maartje Zengerink
    Department of Orthopaedic Surgery, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 18:238-46. 2010
    ..Further sufficiently powered, randomized clinical trials with uniform methodology and validated outcome measures should be initiated to compare the outcome of surgical strategies for OCD of the talus...
  43. ncbi Effect of gamma irradiation on human cortical bone transplants contaminated with enveloped and non-enveloped viruses
    Axel Pruss
    Institute for Transfusion Medicine, Tissue Bank, University Hospital Charite, Medical Faculty of the Humboldt University Berlin, Berlin, Germany
    Biologicals 30:125-33. 2002
    ..We therefore recommend a dose of 34 kGy for the sterilisation of frozen bone transplants...
  44. ncbi Cancellous impaction grafting in the human femur: histological and radiographic observations in 6 autopsy femurs and 8 biopsies
    L Linder
    Department of Orthopedics, Gavle Hospital, Sweden
    Acta Orthop Scand 71:543-52. 2000
    ..Radiographic criteria used to assess primary total joint replacement do not necessarily apply to impaction grafting, and radiographic changes should be interpreted cautiously, especially as regards tissue viability...
  45. ncbi Treatment of severe atrophy of the maxilla with the prefabricated free vascularized fibula flap
    Dennis Rohner
    Department of Reconstructive Surgery, University of Basel, University Hospital, Switzerland
    Clin Oral Implants Res 13:44-52. 2002
    ..The reconstructions with the fibula flaps were successful and the 18 ITI implants that have been inserted showed good osseointegration without loss of attachment in all 4 patients after a mean observation period of 12 months...
  46. ncbi Vertical distraction osteogenesis of fibula transplants for mandibular reconstruction--a preliminary study
    Bernd Klesper
    Department of Maxillo Facial Surgery, Universitat zu Koln, Koln, Germany
    J Craniomaxillofac Surg 30:280-5. 2002
    ..When reconstructing the mandible after tumour resection with a fibular graft, the mandible is often vertically deficient, making placement of dental implants impossible...
  47. pmc Comparative study of laparoscopic L5-S1 fusion versus open mini-ALIF, with a minimum 2-year follow-up
    Sang Ki Chung
    Department of Neurosurgery and General Surgery, Wooridul Spine Hospital, 47 4 Chungdam dong Kangnam gu, 135 100 Seoul, Korea
    Eur Spine J 12:613-7. 2003
    ..The fusion rate was 91% in both groups. The laparoscopic ALIF for L5-S1 showed similar clinical and radiological outcome when compared with open mini-ALIF, but significant advantages were not identified, despite its technical difficulty...
  48. ncbi Laser therapy improves healing of bone defects submitted to autologous bone graft
    João Batista B Weber
    School of Dentistry, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Photomed Laser Surg 24:38-44. 2006
    ..The aim of the present study was to assess histologically the effect of low-level laser thrapy (LLLT) (lambda 830 nm) on the healing of bone defects associated with autologous bone graft...
  49. ncbi Influence of low-level laser treatment on bone regeneration and osseointegration of dental implants following sinus augmentation. An experimental study on sheep
    Norbert Jakse
    Department of Oral Surgery and Radiology, School of Dentistry, Medical University Graz, Graz, Austria
    Clin Oral Implants Res 18:517-24. 2007
    ..The aim of this experimental study was to evaluate if low-level laser treatment (LLLT) enhances bone regeneration and osseointegration of dental implants in a sinus graft model...
  50. ncbi Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology
    M Esposito
    Institute of Anatomy and Cell Biology, Goteborg University, Sweden
    Eur J Oral Sci 106:527-51. 1998
    ..Therefore, it is concluded that further clinical follow-up and retrieval studies are required in order to achieve a better understanding of the mechanisms for failure of osseointegrated implants...
  51. ncbi Assessment of bone repair associated with the use of organic bovine bone and membrane irradiated at 830 nm
    Marleny Elizabeth Márquez Gerbi
    School of Dentistry, Federal University of Bahia, Salvador, Brazil
    Photomed Laser Surg 23:382-8. 2005
    ..6 mm, 16 J/cm(2) per session) on the repair of surgical defects created in the femur of the Wistar Albinus rat. The defects were filled to lyophilized bovine bone (Gen-ox), organic matrix) associated or not to GTR (Gen-derm)...
  52. ncbi Fresh-frozen structural allografts in the foot and ankle
    Mark S Myerson
    Union Memorial Hospital, Baltimore, Maryland, USA
    J Bone Joint Surg Am 87:113-20. 2005
    ..These grafts were used in order to restore more normal dimensions of the foot and ankle following surgery or trauma and to treat arthritis or deformity in situations in which conventional cancellous graft would not be sufficient...
  53. pmc Single-level cervical radiculopathy: clinical outcome and cost-effectiveness of four techniques of anterior cervical discectomy and fusion and disc arthroplasty
    Arup K Bhadra
    Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP, UK
    Eur Spine J 18:232-7. 2009
    ..Single-level cervical radiculopathy was treated with four different techniques. The clinical outcome and cost-effectiveness were compared in this study...
  54. ncbi The use of allografts in orthopaedic surgery
    Steven Gitelis
    Department of Orthopedic Surgery, Rush Medical College, Chicago, Illinois, USA
    Instr Course Lect 51:507-20. 2002
  55. ncbi Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop
    Ulrich Kneser
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Erlangen, Germany
    Tissue Eng 12:1721-31. 2006
    ..Our aim was to induce axial vascularization in a processed bovine cancellous bone (PBCB) matrix using an arteriovenous (AV) loop (artery, vein graft, and vein)...
  56. ncbi Bone allografts pretreated with a bisphosphonate are not resorbed
    Per Aspenberg
    Department of Orthopedics, Linkoping University Hospital, Sweden
    Acta Orthop Scand 73:20-3. 2002
    ..Local graft treatment with a bisphosphonate before insertion seems to be risk-free, and may prevent mechanical graft failure due to resorption in patients...
  57. ncbi Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption. A prospective randomised double-blinded study
    U Kesteris
    Department of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    J Bone Joint Surg Br 88:993-6. 2006
    ..We conclude that rinsing the graft in a bisphosphonate solution prevents its resorption and may therefore reduce the risk of mechanical failure. The treatment is simple, inexpensive, and appears virtually free of risk...
  58. ncbi Pseudarthrosis rate after allograft posterior lumbar interbody fusion with pedicle screw and plate fixation
    J W Brantigan
    Cleveland Spine and Arthritis Center, Ohio
    Spine (Phila Pa 1976) 19:1271-9; discussion 1280. 1994
    ....
  59. ncbi A combination of bisphosphonate and BMP additives in impacted bone allografts
    Charlotte Jeppsson
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    Acta Orthop Scand 74:483-9. 2003
    ..Although the problems associated with the use of OP-1 in impaction grafting may be solved by adding a bisphosphonate, some of the benefits of OP-1 can be lost...
  60. ncbi Polyetheretherketone as a biomaterial for spinal applications
    Jeffrey M Toth
    Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Box 26099, Milwaukee, WI 53226 0099, USA
    Biomaterials 27:324-34. 2006
    ..Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer's increased radiolucency and decreased stiffness...
  61. ncbi Bone morphogenetic protein-induced repair of the premaxillary cleft
    Alan S Herford
    Department of Oral and Maxillofacial Surgery, Loma Linda University Medical Center, Loma Linda, CA 92350, USA
    J Oral Maxillofac Surg 65:2136-41. 2007
    ..The purpose of this study is to evaluate the bony regeneration of premaxillary clefts in humans using recombinant human bone morphogenetic protein type 2 in a collagen sponge carrier...
  62. ncbi The biology of bone grafting
    Safdar N Khan
    Department of Orthopaedic Surgery, The University of California, Davis, Davis, CA, USA
    J Am Acad Orthop Surg 13:77-86. 2005
    ..An elegant cellular and molecular cascade follows bone transplantation. Bone graft incorporation within the host, whether autogenous or allogeneic, depends on many factors: type ..
  63. doi Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects
    Brian P Dickinson
    Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    Plast Reconstr Surg 121:209-17. 2008
    ..A new procedure using a resorbable collagen matrix with bone morphogenetic protein (BMP)-2 was compared with traditional iliac crest bone graft to close alveolar defects in older patients...
  64. ncbi High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties
    Martin A Buttaro
    Hip Surgery Unit, Carlos E Ottolenghi Institute of Orthopaedics, Hospital Italiano de Buenos Aires
    Acta Orthop 76:336-40. 2005
    ..However, local and systemic antibiotic levels, biological activity of vancomycin, interaction with antibiotic-loaded cement, and also nephrotoxicity of these composites have not yet been studied clinically...
  65. pmc No effect of platelet-rich plasma with frozen or processed bone allograft around noncemented implants
    T B Jensen
    Orthopaedic Research Group, Aarhus University Hospital, Aarhus, Denmark
    Int Orthop 29:67-72. 2005
    ..Even though the level of platelet in PRP was 7.7 times that found in whole blood, we found no improvement of bone formation or implant fixation by adding PRP...
  66. ncbi Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits
    Vasilis T Athanasiou
    Department of Orthopedics, University Hospital of Patras, Patras, Greece
    Med Sci Monit 16:BR24-31. 2010
    ..This experimental animal study was undertaken to evaluate the different histological properties of various bone graft substitutes utilized in this hospital...
  67. doi Efficacy of anterior cervical fusion: comparison of titanium cages, polyetheretherketone (PEEK) cages and autogenous bone grafts
    Yu Cheng Chou
    Division of Functional Neuroscience, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    J Clin Neurosci 15:1240-5. 2008
    ..3% in group B, and 84.85% in group C. The fusion rates after 1 year in groups A, B, and C were 46.51%, 100% and 100%, respectively. The PEEK cage is a viable alternative to autogenous tricortical bone grafts in anterior cervical fusion...
  68. ncbi Complications of vascularized fibula graft for reconstruction of long bones
    Kouichi Arai
    Department of Orthopedic Surgery, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, Aomori 036 8562, Japan
    Plast Reconstr Surg 109:2301-6. 2002
    ..Vascularized fibular grafting offers the patient a great deal of benefit; however, this graft has a concomitant high risk of complications. Great attention to detail must be paid to prevent postoperative complications...
  69. ncbi Persistent iliac crest donor site pain: independent outcome assessment
    Robert F Heary
    Department of Neurosurgery, Neurological Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Neurosurgery 50:510-6; discussion 516-7. 2002
    ..In addition, this study identifies the significant discrepancies that are observed when independent outcome assessment results are compared with the incidences determined by review of the operating surgeon's documented findings...
  70. doi Acetabular revision with impacted morsellised cancellous bone grafting and a cemented acetabular component: a 20- to 25-year follow-up
    B W Schreurs
    Department of Orthopaedics, Nijmegen Medical Centre, Radboud University, Intern postcode 357, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Bone Joint Surg Br 91:1148-53. 2009
    ..Acetabular revision using impacted large morsellised bone chips (0.5 cm to 1 cm in diameter) and a cemented acetabular component remains a reliable technique for reconstruction, even when assessed at more than 20 years after surgery...
  71. doi Acetabular bone reconstruction in revision arthroplasty: a comparison of freeze-dried, irradiated and chemically-treated allograft vitalised with autologous marrow versus frozen non-irradiated allograft
    B G Ochs
    BG Trauma Centre, University of Tuebingen, Schnarrenbergstrasse 95, 72076 Tuebingen, Germany
    J Bone Joint Surg Br 90:1164-71. 2008
    ....
  72. doi Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells
    Le Wang
    Institute of Orthopaedics and Traumatology, The Third Affiliated Hospital, Guangzhou Medical University, People s Republic of China
    Biomaterials 31:9452-61. 2010
    ....
  73. ncbi Endoprosthetic and allograft-prosthetic composite reconstruction of the proximal femur for bone neoplasms
    Yasser Farid
    Department of Orthopaedic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Clin Orthop Relat Res 442:223-9. 2006
    ..Level of Evidence: Therapeutic study, Level IV (case series--no, or historical control group). See the Guidelines for Authors for a complete description of levels of evidence...
  74. doi Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate
    Anna Kajsa Harding
    Department of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    J Orthop Res 26:1245-9. 2008
    ..This combination might be useful in various conditions in orthopedic reconstruction...
  75. pmc HLA sensitization and allograft bone graft incorporation
    William G Ward
    Department of Orthopaedics, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, NC 27157 1070, USA
    Clin Orthop Relat Res 466:1837-48. 2008
    ..Based on these preliminary data, measures to further minimize or modulate HLA sensitization or response are not indicated at present for the purposes of improving structural bone allograft union...
  76. doi Donor-site complications of autogenous nonvascularized fibula strut graft harvest for anterior cervical corpectomy and fusion surgery: experience with 163 consecutive cases
    Ahmad Nassr
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55902, USA
    Spine J 9:893-8. 2009
    ..The fibula is a source of bone graft for reconstruction of the appendicular and axial skeleton...
  77. ncbi The use of structural distal femoral allografts for acetabular reconstruction. Average ten-year follow-up
    Scott M Sporer
    Department of Orthopaedic Surgery, Rush University Medical Center, 25 North Winfield Road, Chicago, IL 60190, USA
    J Bone Joint Surg Am 87:760-5. 2005
    ....
  78. ncbi No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks: a bone chamber study in goats
    Gerjon Hannink
    Orthopaedic Research Lab, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Orthop 78:551-8. 2007
    ..In the current study we examined whether this reduction represented a final loss of ingrowth or was just a delay, and whether the reduction can be overcome and ultimately results in a better late ingrowth...
  79. ncbi Five-year follow-up of socket movements and loosening after revision with impacted morselized allograft bone and cement: a radiostereometric and radiographic analysis
    Ewald Ornstein
    Department of Orthopedics, Hässleholm Kristianstad County Hospital, Hassleholm, Sweden
    J Arthroplasty 21:975-84. 2006
    ..The future will show if further sockets loosen and if the loose sockets up to date will end up in rerevisions...
  80. ncbi Morbidity at the iliac crest donor site following bone grafting of the cleft alveolus
    M C Swan
    Department of Plastic and Reconstructive Surgery, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, United Kingdom
    Br J Oral Maxillofac Surg 44:129-33. 2006
    ..Harvesting bone from the iliac crest for alveolar bone grafting is well tolerated by patients, has few important complications, and gives an aesthetically acceptable scar at the donor site...
  81. doi Effect of hyperbaric oxygen on demineralized bone matrix and biphasic calcium phosphate bone substitutes
    Ahmed Jan
    Chief Resident in Oral and Maxillofacial Surgery and Anesthesia, University of Toronto, Toronto, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:59-66. 2010
    ....
  82. ncbi Management of periacetabular bone loss in revision hip arthroplasty
    Petros J Boscainos
    Division of Orthopaedic Surgery, Toronto East General Hospital, Toronto, ON, Canada
    Clin Orthop Relat Res 465:159-65. 2007
    ..In addition, we report our preliminary results with trabecular metal cups and trabecular metal cup-cage constructs used in conjunction with bone graft for addressing major bone defects...
  83. ncbi [Favourable long-term results from cemented total hip arthroplasty combined with acetabular bone impaction grafting in patients under the age of 50]
    V J J F Busch
    Universitair Medisch Centrum St Radboud, afd Orthopedie 800, Postbus 9101, 6500 HB, Nijmegen
    Ned Tijdschr Geneeskd 151:1935-40. 2007
    ..Procedures whereby an existing acetabulum defect was filled with bone chips that were impacted into a strong layer, after which a cemented total hip prosthesis was implanted...
  84. ncbi Long bone reconstruction with vascularized bone grafts
    William C Pederson
    The Hand Center of San Antonio, and Department of Orthopaedic Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78240, USA
    Orthop Clin North Am 38:23-35, v. 2007
    ..The vascularized fibula can be used to maintain growth by virtue of transferring the physis. The vascularized fibula is thus both the workhorse and thoroughbred in long bone construction...
  85. doi Osteoconduction of different sizes of anorganic bone particles in a model of guided bone regeneration
    Xinwen Zhou
    Department of Prothodontics, School of Stomatology, Capital Medical University, Beijing, China
    Br J Oral Maxillofac Surg 49:37-41. 2011
    ..We conclude that the size of grafted particles of bone and the spaces between particles are important determinants of osteogenesis during guided bone regeneration...
  86. ncbi Outcome of secondary alveolar bone grafting before and after eruption of the canine in Jordanian patients with cleft lip and palate
    Ma amon A Rawashdeh
    Department of Oral and Maxillofacial Surgery, Jordan University of Science and Technology and King Abdullah University Hospital, Cleft Lip and Palate Centre, Irbid, Jordan
    J Craniofac Surg 18:1331-7. 2007
    ..Our findings support the conclusion that the outcome of early SABG is superior to late SABG. The overall success rate of SABG sample (74%) compared relatively well with other published results...
  87. ncbi Bone graft materials
    Harry V Precheur
    Department of Oral and Maxillofacial Surgery and Pathology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Dent Clin North Am 51:729-46, viii. 2007
    ..The article also examines some of the research being done in "tissue engineering" to get a sense of the future of bone grafting...
  88. pmc Is an impacted morselized graft in a cage an alternative for reconstructing segmental diaphyseal defects?
    Pieter H J Bullens
    Orthopedic Research Laboratory, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin Orthop Relat Res 467:783-91. 2009
    ..The data suggest that a cage filled with a loaded morselized graft could be an alternative for the massive cortical graft in reconstruction of large diaphyseal defects in an animal model...
  89. ncbi Factors affecting the cohesion of impaction bone graft
    J Oakley
    Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire SY10 7AG, UK
    J Bone Joint Surg Br 88:828-31. 2006
    ..001). Washing had no effect on cohesion. The addition of clotted blood significantly increased the cohesion of both pure bone (p < 0.019) and mixes with pure bone and with porous graft extender (p < 0.044)...
  90. ncbi Systemic zoledronate precoating of a bone graft reduces bone resorption during remodeling
    Magnus Tagil
    Department of Orthopedics, Lund University Hospital SE 221 85 Lund, Linkoping, Sweden
    Acta Orthop 77:23-6. 2006
    ..Bisphosphonates are used to reduce resorption of necrotic bone. We tested a systemic pretreatment before harvesting the graft in order to protect the bone and cartilage against collapse and secondary arthrosis...
  91. pmc Acetabular revision with metal mesh, impaction bone grafting, and a cemented cup
    Martin A Buttaro
    Hip Surgery Unit, Institute of Orthopaedics Carlos E Ottolenghi, Italian Hospital of Buenos Aires, Potosi 4215, C1199ACK, Buenos Aires, Argentina
    Clin Orthop Relat Res 466:2482-90. 2008
    ..Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence...
  92. ncbi Lateral approach for fixation of the fractures of the distal tibia. Outcome of 20 patients. Technical note
    M J Manninen
    Department of Orthopaedics and Traumatology, Helsinki University Hospital, Helsinki, Finland
    Arch Orthop Trauma Surg 127:349-53. 2007
    ..However, increased soft tissue damage and high complication rate has led to search less invasive surgical methods such as minimal invasive plating technique...
  93. ncbi Acetabular revision with extensive allograft impaction and uncemented hydroxyapatite-coated implants. Results after 9 (7-11) years follow-up
    Lars Palm
    Department of Orthopaedic Surgery, University Hospital, Linkoping, Sweden
    J Arthroplasty 22:1083-91. 2007
    ..The limited contact between implant and host bone does not seem to compromise implant survival in the 7- to 11-year perspective...
  94. doi Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction: experimental pilot study in sheep and first clinical application
    H Kokemueller
    Department for Oral and Maxillofacial Surgery, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Int J Oral Maxillofac Surg 39:379-87. 2010
    ..In clinical practice, vascularized bioartificial bone grafts could change the principles of bone transplantation with minimal donor site morbidity and no shape or volume limitations.
  95. ncbi Strontium in the bone-implant interface
    Marianne Toft Vestermark
    Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Aarhus C, Denmark
    Dan Med Bull 58:B4286. 2011
    ..Strontium delivered as doping of an HA bone graft extender showed potential as a dual acting agent in the interface. However, delivery methods of strontium to the bone-implant interface clearly need further investigation...
  96. doi Effect of hyperbaric oxygen on grafted and nongrafted calvarial critical-sized defects
    Ahmed Jan
    Oral and Maxillofacial Surgery, University of Toronto, Toronto, Ontario, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:157-63. 2009
    ..This study was undertaken to evaluate the effect of hyperbaric oxygen (HBO) on the repair of critical-sized defects in the presence and absence of a nonvascularized autogenous bone graft...
  97. ncbi Tissue engineering solutions for cleft palates
    Jennifer L Moreau
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, USA
    J Oral Maxillofac Surg 65:2503-11. 2007
    ..Clefts of the lip and palate are the most prevalent congenital craniofacial birth defect in humans. The developing field of tissue engineering is considered for the management of clefts of the lip and palate...
  98. ncbi A vascularized bone graft for repair of scaphoid nonunion
    S P Steinmann
    Mayo Graduate School of Medicine, Department of Orthopedics, Division of Hand Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Hand Clin 17:647-53, ix. 2001
    ..In patients who fail to heal a scaphoid fracture, several factors may contribute, including delay in treatment, fracture displacement, proximal third location, avascular necrosis, and associated carpal instability...
  99. ncbi Efficacy of porous bovine bone mineral in various types of osseous deficiencies: clinical observations and literature review
    Z Artzi
    Department of Periodontology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel
    Int J Periodontics Restorative Dent 21:395-405. 2001
    ..Grafted material was also identified using follow-up radiographs. In the presented cases, PBBM showed clinically satisfactory results as a biocompatible filler in bone augmentation procedures...
  100. ncbi Comparative radiologic study of bone density and cortical thickness of donor bone used in mandibular reconstruction
    H Myoung
    Department of Oral and Maxillofacial Surgery, Dental Research Institute, College of Dentistry, Seoul National University, Korea
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:23-9. 2001
    ..CONCLUSION: Although more extensive testing is needed to explain the clinical implications of these results, the findings of this study may help clinicians choose the most appropriate donor bone...
  101. ncbi Fibrous tissue armoring increases the mechanical strength of an impacted bone graft
    M Tagil
    Department of Orthopedics, Lund University Hospital, Sweden
    Acta Orthop Scand 72:78-82. 2001
    ..Complete osseous remodeling may not be necessary to obtain a good clinical result with a morselized impacted graft...

Research Grants102 found, 100 shown here

  1. Adult Stem Cells: Osteoblast Differentiation and Engraftment
    David Rowe; Fiscal Year: 2007
    ..This grant will provide a head to head comparison of the osteoprogenitor potential for bone transplantation of cells from 5 different tissues...
  2. Adult Stem Cells: Osteoblast Differentiation and Engraftment
    David W Rowe; Fiscal Year: 2010
    ..This grant will provide a head to head comparison of the osteoprogenitor potential for bone transplantation of cells from 5 different tissues...
  3. Studying models and mechanisms of optic nerve diseases
    Donald Hood; Fiscal Year: 2007
    ..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..
  4. TESTS OF MODELS OF RETINAL DISEASE AND ADAPTATION
    Donald Hood; Fiscal Year: 1993
    ..The data will be analyzed within the context of recent models of cone systems, models based on recent physiology...
  5. MEASURE OF RECEPTOR AND POST RECEPTOR ACTIVITY
    Donald Hood; Fiscal Year: 2002
    ..monkeys in which INL activity is pharmacologically dissected, b. normal human subjects, c. patients with disease of the INL, and d. mathematical work. ..
  6. Tests of Models of Retinal/Optic Nerve Diseases&Adaption
    Donald Hood; Fiscal Year: 2004
    ..Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON). ..
  7. Measures of Human Receptor and Post Receptor Activity
    Donald Hood; Fiscal Year: 2007
    ..We propose as part of aim 3 to improve our understanding of these relationships as well as to improve our analysis of visual field data. ..
  8. MEASURE OF HUMAN RECEPTOR AND POST-RECEPTOR ACTIVITY
    Donald Hood; Fiscal Year: 1993
    ..Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors...
  9. Measures of Human Receptor and Post Receptor Activity
    Donald C Hood; Fiscal Year: 2010
    ..These same techniques can enable the ophthalmologist to monitor the health of these cells and, thus the effectiveness of alternative treatments. ..
  10. Studying models and mechanisms of optic nerve diseases
    Donald Hood; Fiscal Year: 2009
    ..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..
  11. Prospective evaluation of immediate temporized implants
    Michael Block; Fiscal Year: 2007
    ..Standardized hard and soft tissue data will be collected preextraction as baseline, and then prospectively for at least two years in this trial, to compare and contrast the methods. ..
  12. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  13. Prevention of Biofilm Related Infections Using a Novel, Broad Spectrum Antimicrob
    ROY DRAKE BLOEBAUM; Fiscal Year: 2010
    ..We hope this will give civilian and military patients a more sure way of avoiding infection in grossly contaminated wounds. ..
  14. TESTS OF MODELS OF RETINAL DISEASE ADAPTATION
    Donald Hood; Fiscal Year: 2000
    ..This could be especially valuable in assessing retinal function of patients with heterogeneous damage as in retinitis pigmentosa, diabetic retinopathy, and glaucoma. ..
  15. NONLINEAR STRESS/STRAIN BEHAVIOR OF CORTICAL BONE
    DWIGHT DAVY; Fiscal Year: 1999
    ....
  16. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..
  17. TESTS OF MODELS OF RETINAL DISEASE AND ADAPTATION
    Donald Hood; Fiscal Year: 1991
    ..Finally, we intend to obtain a better understanding of the relative involvement of the rod and different cone mechanisms in retinitis pigmentosa and in progressive cone dystrophy...
  18. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..We propose to determine the relationship between subchondral bone architecture, cartilaginous endplate composition and organization, and the initiation and progression of IVD degeneration in cadaveric human lumbar spines. ..
  19. Enabling Technologies for hES Cell Self-Renewal
    KEVIN HEALY; Fiscal Year: 2009
    ....
  20. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ....
  21. Cellular Contribution to Bone Healing
    Celine Colnot; Fiscal Year: 2006
    ..abstract_text> ..
  22. Gene Transfer of Hematopoietic Stem Cells
    Christopher Walsh; Fiscal Year: 2004
    ..Information obtained from the planned studies will provide a better understanding of abnormal hematopoiesis in FA and better define therapeutic strategies important for designing future human clinical trials. ..
  23. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
    ..4. Image the three-dimensional damage developed in cortical bone specimens following low cycle fatigue in four point bending. Differences in damage patterns due to pure bending and combined bending and shear loading will be identified. ..
  24. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen Bishop; Fiscal Year: 2009
    ....
  25. Nanopatterned Surfaces to Control Cell Fate
    KEVIN EDWARD HEALY; Fiscal Year: 2010
    ....
  26. Gene Therapy for the Hemophilias
    Christopher Walsh; Fiscal Year: 2006
    ..Each method will be optimized and in AAV vectors for FVIII production and tested in vivo using immunodeficient and FVIII knockout mice and hemophilic A canines. ..
  27. Angiogenesis & Osteogenesis in Structural Graft Healing
    Xinping Zhang; Fiscal Year: 2007
    ..abstract_text> ..
  28. Rabbit Model for In Vivo Monitoring of Bone Structure
    Michael Voor; Fiscal Year: 2003
    ..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
  29. Nanopatterned Surfaces to Control Cell Fate
    KEVIN HEALY; Fiscal Year: 2009
    ....
  30. Tissue Engineering a Suture Replacement for Children with Craniosynostosis
    Gregory M Cooper; Fiscal Year: 2010
    ..The technology that will be developed in performing the proposed work will have broad impact on the field of stem cell biology, the application of tissue engineering, and on the treatment of children with craniosynostosis. ..
  31. Analyses of InSitu and Explanted Surgical Implant Devices
    Jack Lemons; Fiscal Year: 2009
    ..abstract_text> ..
  32. Dental Implant Science & Tech Transfer Satellite Meeting
    Jack Lemons; Fiscal Year: 2004
    ..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
  33. Analyses of InSitu and Explanted Surgical Implant Devic
    Jack Lemons; Fiscal Year: 2005
    ..abstract_text> ..
  34. Tissue Engineering a Suture Replacement for Children with Craniosynostosis
    Gregory Cooper; Fiscal Year: 2009
    ..The technology that will be developed in performing the proposed work will have broad impact on the field of stem cell biology, the application of tissue engineering, and on the treatment of children with craniosynostosis. ..