fluid therapy

Summary

Summary: Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to water-electrolyte balance. Fluids may be administered intravenously, orally, by intermittent gavage, or by hypodermoclysis.

Top Publications

  1. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
  2. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  3. ncbi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
  4. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  5. ncbi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
  6. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
  7. ncbi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
  8. ncbi Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients
    Konrad Reinhart
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 38:368-83. 2012
  9. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
  10. ncbi Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011

Detail Information

Publications409 found, 100 shown here

  1. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
  2. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  3. ncbi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
    ..The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established...
  4. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  5. ncbi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
    ..The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported...
  6. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
    ..We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a heterogeneous population of patients in the ICU...
  7. ncbi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
    ..Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis...
  8. ncbi Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients
    Konrad Reinhart
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 38:368-83. 2012
    ....
  9. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
    ..The objective of this study was to determine whether early septic shock reversal and use of resuscitation practice consistent with the new ACCM-PALS Guidelines by community physicians is associated with improved outcome...
  10. ncbi Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  11. ncbi Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery
    H G Wakeling
    Department of Anaesthesia, Worthing Hospital, Lyndhurst Road, Worthing BN11 2DH, UK
    Br J Anaesth 95:634-42. 2005
    ..We assessed whether using intraoperative oesophageal Doppler guided fluid management to minimize hypovolaemia would reduce postoperative hospital stay and the time before return of gut function after colorectal surgery...
  12. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  13. ncbi Assessing fluid responsiveness in critically ill patients: False-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricle
    Yazine Mahjoub
    Medical YM, CP, AF, El, Ft, CG, HD and Surgical Intensive Care Unit EZ, Department of Anesthesia and Intensive Care, Amiens University Hospital, Amiens, France
    Crit Care Med 37:2570-5. 2009
    ..Pulse pressure variation is used to predict fluid responsiveness in mechanically ventilated patients. However, this parameter has been reported to be falsely positive, especially in patients with right ventricular dysfunction...
  14. pmc Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial
    Birgitte Brandstrup
    Clinical Unit of Preventive Medicine and Health Promotion, H S Bispebjerg University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Ann Surg 238:641-8. 2003
    ..To investigate the effect of a restricted intravenous fluid regimen versus a standard regimen on complications after colorectal resection...
  15. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  16. ncbi Passive leg raising predicts fluid responsiveness in the critically ill
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
    Crit Care Med 34:1402-7. 2006
    ..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
  17. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
    ....
  18. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  19. ncbi Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures
    R Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, W Sussex UK
    Br J Anaesth 88:65-71. 2002
    ..conventional intraoperative fluid management with two differing methods of invasive haemodynamic monitoring to optimize intraoperative fluid therapy, in patients undergoing proximal femoral fracture repair under general anaesthesia.
  20. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  21. pmc Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study
    Jan Benes
    Department of Anesthesiology and Intensive Care, Charles University Teaching Hospital, Alej Svobody 80, Plzen 304 60, Czech Republic
    Crit Care 14:R118. 2010
    ..variation (SVV) is a good and easily obtainable predictor of fluid responsiveness, which can be used to guide fluid therapy in mechanically ventilated patients...
  22. ncbi The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension
    Yazine Mahjoub
    Medical and Surgical Intensive Care Unit, Department of Anesthesia and Intensive Care, Amiens University Medical Center, Amiens, France
    Crit Care Med 38:1824-9. 2010
    ..The aim of the present study was to determine whether intra-abdominal hypertension (which impairs venous return) reduces the ability of passive leg raising to detect fluid responsiveness in critically ill ventilated patients...
  23. ncbi Saline or albumin for fluid resuscitation in patients with traumatic brain injury
    John Myburgh
    ANZICS Clinical Trials Group, Level 3, 10 Ievers Terrace, Carlton, VIC 3053, Australia
    N Engl J Med 357:874-84. 2007
    ..We conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study...
  24. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  25. ncbi Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
    Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed.
  26. doi American Burn Association practice guidelines burn shock resuscitation
    Tam N Pham
    University of Washington Burn Center, Seattle, Washington 98104, USA
    J Burn Care Res 29:257-66. 2008
  27. ncbi Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
    ..Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids...
  28. ncbi A rational approach to perioperative fluid management
    Daniel Chappell
    Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 109:723-40. 2008
    ..Therefore, undifferentiated fluid handling may increase the shift toward the interstitial space. Using the right kind of fluid in appropriate amounts at the right time might improve patient outcome...
  29. ncbi Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study
    Marc Jacques Dubois
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:2536-40. 2006
    ..To test the hypothesis that administration of albumin to correct hypoalbuminemia might have beneficial effects on organ function in a mixed population of critically ill patients...
  30. ncbi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    ..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
  31. pmc Examining the use of oral rehydration salts and other oral rehydration therapy for childhood diarrhea in Kenya
    Lauren S Blum
    Am J Trop Med Hyg 85:1126-33. 2011
    ..Health communication is needed to clarify the function of ORT in preventing dehydration...
  32. pmc Restrictive strategy of intraoperative fluid maintenance during optimization of oxygen delivery decreases major complications after high-risk surgery
    Suzana M Lobo
    Division of Intensive Care, Department of Internal Medicine, Faculdade de Medicina de Sao Jose do Rio Preto, Av Faria Lima 5544, Sao Jose do Rio Preto, CEP 15090 000, Brazil
    Crit Care 15:R226. 2011
    ..We evaluated the effects of a restrictive versus conventional strategy of crystalloid administration during goal-directed therapy in high-risk surgical patients...
  33. ncbi Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation
    Bodin Khwannimit
    Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Eur J Anaesthesiol 29:64-9. 2012
    ....
  34. pmc Totem and taboo: fluids in sepsis
    Andrew K Hilton
    Department of Intensive Care, Alfred Hospital, Commercial Road, Melbourne, Australia, Victoria 3181, Australia
    Crit Care 15:164. 2011
    ....
  35. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  36. ncbi Monitoring intravascular volumes for postoperative volume therapy
    H Brock
    General Hospital, Department of Anaesthesia and Intensive Care Medicine, Linz, Austria
    Eur J Anaesthesiol 19:288-94. 2002
    ..The feasibility of monitoring measured intravascular volumes and the cardiac filling pressures were compared to reflect the optimal volume status of postoperative patients...
  37. ncbi Clinical practice. Acute infectious diarrhea
    Nathan M Thielman
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 350:38-47. 2004
  38. pmc A balanced view of balanced solutions
    Bertrand Guidet
    INSERM, Unité de Recherche en Épidémiologie Systèmes d Information et Modélisation U707, Paris F 75012, France
    Crit Care 14:325. 2010
    The present review of fluid therapy studies using balanced solutions versus isotonic saline fluids (both crystalloids and colloids) aims to address recent controversy in this topic...
  39. ncbi Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesthesiology 98:699-704. 2003
    ..The authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs...
  40. pmc Community case management of childhood diarrhea in a setting with declining use of oral rehydration therapy: findings from cross-sectional studies among primary household caregivers, Kenya, 2007
    Christine K Olson
    Epidemic Intelligence Service and Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 85:1134-40. 2011
    ..Health workers have a critical role in empowering caregivers regarding early treatment with ORT and continued feeding. Increasing community ORS availability is essential to improving diarrhea management...
  41. ncbi The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies
    Bryan A Cotton
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Shock 26:115-21. 2006
    ..Future resuscitation research is likely to focus on improvements in fluid composition and adjuncts to administration of large volume of fluid...
  42. ncbi Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressure
    Chung Chi Huang
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
    Crit Care Med 36:2810-6. 2008
    ....
  43. ncbi Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studies
    Fabio Cavallaro
    Department of Anesthesiology and Intensive Care, Intensive Care Unit, Catholic University School of Medicine, Agostino Gemelli Hospital, Rome, Italy
    Intensive Care Med 36:1475-83. 2010
    ..To systematically review the published evidence on the ability of passive leg raising-induced changes in cardiac output (PLR-cCO) and in arterial pulse pressure (PLR-cPP) to predict fluid responsiveness...
  44. pmc A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer
    Chun Kheng Khoo
    Department of Surgery, Musgrove Park Hospital, Taunton and Somerset NHS Trust, Taunton, UK
    Ann Surg 245:867-72. 2007
    ..A prospective randomized controlled trial (RCT) of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer...
  45. ncbi Severe hypoxemic respiratory failure: part 2--nonventilatory strategies
    Suhail Raoof
    Division of Pulmonary and Critical Care Medicine, New York Methodist Hospital, 506 Sixth St, Brooklyn, NY 11215, USA
    Chest 137:1437-48. 2010
    ..These interventions may be considered for use, particularly for cases of refractory severe hypoxemia, with proper appreciation of potential costs and adverse effects...
  46. pmc Diarrhoea case management in low- and middle-income countries--an unfinished agenda
    Birger Carl Forsberg
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Bull World Health Organ 85:42-8. 2007
    ..To ascertain whether diarrhoea management improved during 1986-2003, a period when significant efforts were made to promote effective case management in children...
  47. pmc Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study
    Moritz Wyler von Ballmoos
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Crit Care 14:R111. 2010
    ..We aimed to assess prediction of volume responsiveness with PPV in patients with increased pulmonary artery pressure...
  48. ncbi Home management of diarrhea among underfives in a rural community in Kenya: household perceptions and practices
    Doreen M Othero
    Maseno University, School of Public Health and Community Development, Private Bag, Maseno Kenya
    East Afr J Public Health 5:142-6. 2008
    ..Home management of diarrhea is one of the key household practices targeted for enhancement in the Community Integrated Management of Childhood Illness (C-IMCI) strategy...
  49. ncbi Fluid resuscitation: past, present, and the future
    Heena P Santry
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Shock 33:229-41. 2010
    ..Thus, we describe how some novel resuscitation strategies aimed at preventing or ameliorating cellular injury may become clinically available in the future...
  50. ncbi Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  51. pmc Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
    Ronald J Trof
    Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
    Intensive Care Med 36:697-701. 2010
    ..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
  52. ncbi Progress and barriers for the control of diarrhoeal disease
    Mathuram Santosham
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 376:63-7. 2010
    ....
  53. ncbi Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: a clinical, prospective, randomized, controlled study
    A Egge
    Department of Neurosurgery, , Norway
    Neurosurgery 49:593-605; discussion 605-6. 2001
    OBJECTIVE: To investigate the role of prophylactic hyperdynamic postoperative fluid therapy in preventing delayed ischemic neurological deficits attributable to cerebral vasospasm...
  54. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  55. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  56. ncbi Assessing fluid responsiveness during open chest conditions
    D A Reuter
    Department of Anaesthesiology, University of Munich, 81377 Munich, Germany
    Br J Anaesth 94:318-23. 2005
    ..The aim of this study was to investigate the ability of SVV and PPV measured by arterial pulse contour analysis to assess fluid responsiveness in patients undergoing coronary artery bypass surgery during open-chest conditions...
  57. pmc How the cholera epidemic of 1831 resulted in a new technique for fluid resuscitation
    B A Foex
    Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Emerg Med J 20:316-8. 2003
  58. ncbi A pilot test of the addition of zinc to the current case management package of diarrhea in a primary health care setting
    Nita Bhandari
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    J Pediatr Gastroenterol Nutr 41:685-7. 2005
    ..Reduction in use of drugs during diarrhea ranged from 34% for tablets to 64% for injections 6 months later. The cost of treatment to families declined significantly. These findings need confirmation in a randomized controlled trial...
  59. ncbi Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?
    Michael C Madigan
    Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:280-5. 2008
    ..We hypothesized that poor resuscitation techniques, including early and excessive crystalloid administration, places patients with extremity injuries at risk for developing secondary ACS...
  60. ncbi Haemostatic resuscitation
    R P Dutton
    Department of Anesthesia and Critical Care, University of Chicago, Anesthesia Quality Institute 520 N Northwest Highway, Park Ridge, IL 60068, USA
    Br J Anaesth 109:i39-i46. 2012
    ..Future directions for resuscitation research are discussed...
  61. pmc Use of deferred consent for severely ill children in a multi-centre phase III trial
    Kathryn Maitland
    Kemri Wellcome Centre for Geographic medicine, Coast, Kenya
    Trials 12:90. 2011
    ..Across Europe and the United States stringent regulations have resulted in a substantial decline of clinical trials involving emergency interventions...
  62. pmc Hydroxyethyl starch - the importance of being earnest
    Daniel Chappell
    Department of Anaesthesiology, University Hospital of Munich, Nussbaumstrasse 20, 80336 Munich, Germany
    Scand J Trauma Resusc Emerg Med 21:61. 2013
    ..An authority being able to dictate behavior should stand clear from oppressively ending a worldwide expert discussion and step back into the role of the observer until science achieves an agreement...
  63. ncbi Variation of left ventricular outflow tract velocity and global end-diastolic volume index reliably predict fluid responsiveness in cardiac surgery patients
    Ole Broch
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Crit Care 27:325.e7-13. 2012
    ..The aim of the present study was to challenge the predictive power of GEDVI and ΔVTI(LVOT) compared with pulse pressure variation (PPV) and stroke volume variation (SVV) in a large patient population...
  64. ncbi Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery
    C Challand
    Directorate of Gastroenterology, Theatres and Pain, Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth PL6 8DH, UK
    Br J Anaesth 108:53-62. 2012
    Intraoperative fluid therapy regimens using oesophageal Doppler monitoring (ODM) to optimize stroke volume (SV) (goal-directed fluid therapy, GDT) have been associated with a reduction in length of stay (LOS) and complication rates after ..
  65. pmc Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study
    Simon Finfer
    Australian and New Zealand Intensive Care Society Clinical Trials Group, Carlton, VIC 3053, Australia
    BMJ 333:1044. 2006
    ..To determine whether outcomes of resuscitation with albumin or saline in the intensive care unit depend on patients' baseline serum albumin concentration...
  66. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  67. ncbi Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre study
    Thomas W L Scheeren
    Department of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Clin Monit Comput 27:225-33. 2013
    ..Our findings also suggest that a goal-directed strategy might decrease postoperative organ dysfunction...
  68. ncbi Management of gastroenteritis over 10 years: changing culture and maintaining the change
    Joanne Fox
    Department of Child Health, Children s Hospital for Wales, Heath Park, Cardiff, UK
    Arch Dis Child 97:415-7. 2012
    ..To examine the impact of an implementation program on adherence to a guideline for the management of acute gastroenteritis...
  69. pmc Zinc and low osmolarity oral rehydration salts for diarrhoea: a renewed call to action
    Christa L Fischer Walker
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Bull World Health Organ 87:780-6. 2009
    ..Revitalizing diarrhoea management must become an international priority if we are going to reduce the burden of diarrhoea deaths and overall child mortality around the world...
  70. ncbi Safety of gelatin for volume resuscitation--a systematic review and meta-analysis
    D O Thomas-Rueddel
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    Intensive Care Med 38:1134-42. 2012
    ..Gelatin is frequently used as a volume expander in critical care. Our goal was to investigate its safety...
  71. pmc Operational issues and trends associated with the pilot introduction of zinc for childhood diarrhoea in Bougouni district, Mali
    Peter J Winch
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2103, USA
    J Health Popul Nutr 26:151-62. 2008
    ....
  72. ncbi Practice and attitudes regarding the management of childhood diarrhoea among pharmacies in Thailand
    Woranuch Saengcharoen
    Department of Clinical Pharmacy and Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Int J Pharm Pract 18:323-31. 2010
    ....
  73. ncbi Adjunctive management of malaria
    Sanjeev Krishna
    Division of Clinical Sciences, Centre for Infection and Immunity, St George s University of London, London, UK
    Curr Opin Infect Dis 25:484-8. 2012
    ..Identifying new adjunct approaches has been particularly difficult for severe malaria because most interventions have either caused harm or failed to confer benefit...
  74. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003
    ..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
  75. pmc Cardiac filling volumes versus pressures for predicting fluid responsiveness after cardiovascular surgery: the role of systolic cardiac function
    Ronald J Trof
    Vrije Universiteit Medical Centre, Department of Intensive Care, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Crit Care 15:R73. 2011
    ....
  76. ncbi Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 41:1774-81. 2013
    ..Despite a previous meta-analysis that concluded that central venous pressure should not be used to make clinical decisions regarding fluid management, central venous pressure continues to be recommended for this purpose...
  77. ncbi Initial fluid resuscitation of patients with septic shock in the intensive care unit
    S Carlsen
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 55:394-400. 2011
    ..Our aim was to evaluate the current initial fluid resuscitation practice in patients with septic shock in the intensive care unit (ICU) and patient characteristics and outcome associated with fluid volume...
  78. ncbi Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison
    Ole Bayer
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
    Crit Care Med 39:1335-42. 2011
    ..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury.
  79. ncbi The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patients
    Cyril Charron
    Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
    Anesth Analg 102:1511-7. 2006
    ..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
  80. ncbi Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery
    H Berkenstadt
    Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Anesth Analg 92:984-9. 2001
    ..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
  81. ncbi Fluid resuscitation strategies: a systematic review of animal trials
    James Mapstone
    Public Health Medicine, Castle Point and Rochford Primary Care Trust, Rayleigh, Essex, United Kingdom
    J Trauma 55:571-89. 2003
    ..Our objective was to systematically review randomized, controlled trials of fluid resuscitation in animal models of uncontrolled hemorrhage and to explore potential sources of heterogeneity...
  82. ncbi Effects of albumin 5% and artificial colloids on clot formation in small infants
    T Haas
    Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anaesthesia 62:1000-7. 2007
    ..From a haemostatic point of view it might be preferable to use gelatine solution as an alternative to albumin; HES showed the greatest effects on the overall coagulation process...
  83. pmc Fluid intake and decreased risk for hospitalization for dengue fever, Nicaragua
    Eva Harris
    University of California, Berkeley, California 94720 6350, USA
    Emerg Infect Dis 9:1003-6. 2003
    ..Similar results were obtained for children <15 years of age and older adolescents and adults in independent analyses...
  84. ncbi Dynamic indices do not predict volume responsiveness in routine clinical practice
    B Lansdorp
    MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    Br J Anaesth 108:395-401. 2012
    ....
  85. ncbi The importance of fluid management in acute lung injury secondary to septic shock
    Claire V Murphy
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
    Chest 136:102-9. 2009
    ..Because these may be seen as potentially conflicting practices, we set out to determine the influence of fluid management on the outcomes of patients with septic shock complicated by ALI...
  86. ncbi Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon
    Oliver Kimberger
    Department of Anesthesiology and Pain Therapy, Inselspital University Hospital Bern, Switzerland
    Anesthesiology 110:496-504. 2009
    The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon ..
  87. ncbi Dopexamine has no additional benefit in high-risk patients receiving goal-directed fluid therapy undergoing major abdominal surgery
    Simon J Davies
    Department of Anaesthesia, York Teaching Hospitals NHS Foundation Trust, North Yorkshire, United Kingdom
    Anesth Analg 112:130-8. 2011
    ..In this study, we assessed the effects of low-dose dopexamine on morbidity after major abdominal surgery in patients who were at increased risk by virtue of a reduced AT...
  88. ncbi Dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    Crit Care Med 37:510-5. 2009
    ..However, in open-chest conditions, the value of these indices has not been systematically examined yet. We, therefore, evaluated the ability of PPV and SVV to predict fluid responsiveness under open- and closed-chest conditions...
  89. pmc A critique of fluid bolus resuscitation in severe sepsis
    Andrew K Hilton
    Department of Intensive Care, Alfred Hospital, and Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Crit Care 16:302. 2012
    ..In the present article, we contend that the concept of large fluid bolus resuscitation in sepsis needs to be investigated further...
  90. ncbi Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a "gray zone" approach
    Maxime Cannesson
    Department of Anesthesiology and Perioperative Care, School of Medicine, University of California, Irvine, Irvine, California, USA
    Anesthesiology 115:231-41. 2011
    ..The authors sought to test the predictive value of PPV in a large, multicenter study and to express it using a gray zone approach...
  91. ncbi Errors in fluid therapy in medical wards
    Maryam Mousavi
    Tehran University of Medical Sciences, Tehran, Iran
    Int J Clin Pharm 34:374-81. 2012
    Intravenous fluid therapy remains an essential part of patients' care during hospitalization...
  92. ncbi Supplemental perioperative fluid administration increases tissue oxygen pressure
    Cem F Arkilic
    Department of Anesthesiology, Section of Colon and Rectal Surgery, Washington University, St Louis, MO, USA
    Surgery 133:49-55. 2003
    ..We tested the hypothesis that supplemental fluid administration during and after elective colon resection increases tissue perfusion and tissue oxygen pressure...
  93. ncbi Perioperative monitoring of fluid responsiveness after esophageal surgery using stroke volume variation
    Makoto Kobayashi
    Surgical Division, Hakodate Goryoukaku Hospital, 38 3 Goryoukaku cho, Hakodate City, Hokkaido, Japan
    Expert Rev Med Devices 5:311-6. 2008
    ..To assess the utility of a new arterial pressure-based cardiac output (FloTrac) and central venous oximetry (PreSep) monitoring system in the perioperative management of patients undergoing radical esophagectomy...
  94. ncbi Determinants of use rate of oral rehydration therapy for management of childhood diarrhoea in rural Bangladesh
    M Ali
    Department of General Practice, University of Western Australia, Fremantle Hospital, Australia
    J Health Popul Nutr 18:103-8. 2000
    ..Promotion of ORT can be effected by improving the level of understanding of mothers with regard to assessment of severity, early initiation of treatment regardless of age, sex, type of diarrhoea, breast-feeding, and nutrition status...
  95. ncbi The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen, Germany
    Intensive Care Med 36:1299-308. 2010
    ..This review presents the (patho)physiological basis of hypovolemia, microcirculation, and tissue oxygenation and presents a literature review on the effects of plasma substitutes on microperfusion and oxygenation in the clinical setting...
  96. ncbi Physiological effects of hyperchloraemia and acidosis
    J M Handy
    Chelsea and Westminster NHS Foundation Trust, Imperial College London, 369 Fulham Road, London SW10 9NH, UK
    Br J Anaesth 101:141-50. 2008
    ..It is intended to provide an assessment of the importance of hyperchloraemic acidosis and thereby the likely benefits of balanced solutions...
  97. ncbi The Parkland formula under fire: is the criticism justified?
    Jennifer Blumetti
    University of Texas Southwestern, Dallas, Texas, USA
    J Burn Care Res 29:180-6. 2008
    ..The Parkland formula only represents a resuscitation "starting" point. The UOP is the important parameter...
  98. ncbi Arterial versus plethysmographic dynamic indices to test responsiveness for testing fluid administration in hypotensive patients: a clinical trial
    Giuseppe Natalini
    Department of Anesthesiology, Intensive Care Medicine and Emergency Medicine, Poliambulanza Foundation Hospital, Brescia, Italy
    Anesth Analg 103:1478-84. 2006
    ..These plethysmographic indices could provide a noninvasive tool for predicting the cardiac output increase by administering fluid...
  99. ncbi Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 37:650-8. 2009
    ..Therefore, the present study was designed to evaluate whether PPV and SVV are suitable for predicting fluid responsiveness during elevated IAP...
  100. ncbi Safety of rapid intravenous rehydration and comparative efficacy of 3 oral rehydration solutions in the treatment of severely malnourished children with dehydrating cholera
    Nur H Alam
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    J Pediatr Gastroenterol Nutr 48:318-27. 2009
    ..Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions...
  101. ncbi Predicting increased fluid requirements during the resuscitation of thermally injured patients
    Leopoldo C Cancio
    US Army Institute of Surgical Research, Charleston, South Carolina, USA
    J Trauma 56:404-13; discussion 413-4. 2004
    ....

Research Grants63

  1. Assessment of Dehydration in Children with Diarrhea in Resource-Limited Settings
    ADAM CARL LEVINE; Fiscal Year: 2013
    ....
  2. The role of prophage life cycle in Stx production and disease due to EHEC
    Kathryn A Eaton; Fiscal Year: 2013
    ..When HUS does occur, it is often after recovery from the diarrheic phase. Intensive fluid therapy instituted at the time of EHEC diagnosis has shown to be somewhat protective against HUS development, but ..
  3. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    Ernest M Wright; Fiscal Year: 2013
    ..g. the Na/iodide and SGLT2, and the structurally related serotonin reuptake transporter (SERT) in brain and enteric nervous systems. ..
  4. Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis
    Nathan Kuppermann; Fiscal Year: 2013
    ..The relationship of fluid therapy for DKA and risk of cerebral injury and cerebral edema is not well understood and has been debated for decades...
  5. Probiotics in Pediatric Diarrhea in Peru_Supplement
    Richard A Oberhelman; Fiscal Year: 2012
    ....
  6. Investigation of Effective Training of "promotoras" in Oral Rehydration Therapy
    RACHEL ANN HALL-CLIFFORD; Fiscal Year: 2013
    ..These results are expected to have an important positive impact by improving the efficacy and sustainability of ORT education campaigns through encouraging local collaboration and ownership of program content. ..
  7. Cellular Molecular Mechanisms of Alanyl-Glutamine Oral Rehydration and Nutrition
    SEAN RYAN MOORE; Fiscal Year: 2013
    ..Furthermore, this outstanding training opportunity will provide me with the foundation necessary for a successful career as an independent global health scientist. ..
  8. Identification of novel inhibitors of a Vibrio cholerae stress response pathway
    Jyl S Matson; Fiscal Year: 2013
    ..cholerae colonization in an animal model of disease will have been identified. This contribution will be significant because it is the first step toward the development of new and fundamentally different therapeutics for cholera. ..
  9. Bedside Monitor to Quantify Cardiac Shunt Flow in Newborns and Small Children
    Nikolai M Krivitski; Fiscal Year: 2012
    ..Timely and accurate quantitative assessment of Qp/Qs permits successful pharmacologic, ventilator or fluid therapy or in time surgical intervention...
  10. Probiotics for Infectious Diarrhea in Children in South India
    Honorine Ward; Fiscal Year: 2009
    ..These studies are important to help understand whether and how probiotics work in protecting and healing the intestine. ..
  11. INTRAVENOUS FLUID THERAPY AND HEAD INJURY
    Steven Shackford; Fiscal Year: 1990
    ..Intravenous fluid therapy is necessary in all of these patients, especially those who require resuscitation from hypovolemic shock...
  12. PROBIOTICS IN PEDIATRIC DIARRHEA IN PERU: PLANNING GRANT
    Richard Oberhelman; Fiscal Year: 2006
    ..Support for these activities during a planning period before the clinical trial will greatly facilitate the implementation of the trial. ..
  13. RESISTANT STARCH: ADJUNCT TO ORAL REHYDRATION SOLUTION
    HENRY BINDER; Fiscal Year: 2000
    ..Treatment failures will be categorized and recorded. If resistant starch is found to reduce fecal volumes and/or duration of diarrhea, this innovative therapy must then be tested in the community for acceptance. ..
  14. Alanyl-glutamine as Oral Rehydration & Nutrition Therapy
    GERLY BRITO; Fiscal Year: 2001
    ..proposed commercial application: not available ..
  15. MECHANISMS OF INTESTINAL CELL MIGRATION
    JON RHOADS; Fiscal Year: 2001
    ..Active growth peptides in serum will be identified and quantified. We will determine if ARG potentiates serum growth factor signaling or activates separate signaling pathways during migration. ..
  16. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2005
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  17. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  18. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  19. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  20. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  21. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  22. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  23. Quantifying Left Ventricular Ejection Effectiveness
    Michael Pinsky; Fiscal Year: 2007
    ..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..
  24. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard L Guerrant; Fiscal Year: 2010
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  25. Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled Trial
    Eduardo Bruera; Fiscal Year: 2009
    ..In this study, we will test if giving fluid through the vein will improve the symptoms, delay confusion and prolong life in patients who are no longer to drink at the end of life. ..
  26. Methylphenidate for Fatigue in Advanced Cancer Patients
    Eduardo Bruera; Fiscal Year: 2009
    ....
  27. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..Relevance to Public Health: In this study, we will test if methadone is better than morphine in cancer pain control, quality of life, and is more cost-effective. ..
  28. COLONIC CRYPT CELL FUNCTION
    HENRY BINDER; Fiscal Year: 2001
    ..We plan to establish the cellular model and the regulatory control of agonist-induced colonic bicarbonate secretion. These studies should define the cellular mechanisms of Na/C1/HCO/3 absorption and secretion in the colonic crypt. ..
  29. Colonic Crypt HCO3 Secretion
    HENRY BINDER; Fiscal Year: 2006
    ..e., cNBC) differs substantially from other NBCs and may represent a novel epithelial cell NBC. We propose comprehensive transport, electrophysiological and molecular studies to characterize crypt HCO3 secretion. ..
  30. Socioeconomic and Ethnic Disparities in Adult Health
    Narayan Sastry; Fiscal Year: 2008
    ..L.A.FANS-2/Adult data will publicly released as quickly as possible once fieldwork is complete, to enable a wide range of researchers to conduct research. ..
  31. IMMUNE RESPONSES TO PNEUMOCOCCAL ANTIGENS IN CHILDREN
    Lisa Kobrynski; Fiscal Year: 2003
    ..In addition, the applicant will pursue further training in study design and research methods, including didactic courses at the Rollins School of Public Health and the Graduate Division of Biological and Biomedical Sciences, at Emory. ..
  32. Dynamics of Peritoneal Dialysis Associated Peritonitis
    John Hotchkiss; Fiscal Year: 2004
    ..Prolonged courses of antibiotic therapy required by compromised host defenses may render the dialysis population an effective "incubator" for drug resistant microorganisms. ..
  33. BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIA
    Myron Levine; Fiscal Year: 2004
    ..falciparum, and by these effects working in concert, we will ultimately be able to prevent disease completely in some subjects and to markedly ameliorate disease severity in others. ..
  34. Models of Birthweight and Low Birthweight
    Narayan Sastry; Fiscal Year: 2004
    ..The first is the 1997 Natality Data Set (NDS), compiled from birth certificates by the National Center for Health Statistics. The second data source is the 1988 National Maternal and Infant Health Survey (NMIHS). ..
  35. Calcium Signaling in Developing Intestinal Epithelium
    Mrinalini Rao; Fiscal Year: 2005
    ....
  36. Homicide During Robbery: A Case-Control Study
    Stephen Marshall; Fiscal Year: 2004
    ..The results of this study will assist in targeting prevention resources to specific high-risk workplaces and neighborhoods. ..
  37. Causal Analysis of Encouragement Design Studies
    Xiao Hua Zhou; Fiscal Year: 2004
    ..In this proposal, we will develop a general statistical methodology for causal treatment analysis of the randomized EDS when data have a complicated structure. ..
  38. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  39. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  40. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  41. SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLS
    Patricia Chess; Fiscal Year: 2003
    ..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..
  42. Continuation of Dialysis Access Consortium Clinical Trials
    Jonathan Himmelfarb; Fiscal Year: 2007
    ..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..
  43. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..abstract_text> ..
  44. Hypertrophic Scarring After Partial-Thickness Wounds
    LOREN ENGRAV; Fiscal Year: 2006
    ..We will laser capture microdissect cones from shallow and deep partial-thickness Duroc wounds, extract and amplify the mRNA, and perform porcine DNA array analysis to determine which genes are differentially expressed. ..
  45. Self Monitoring of Dietary and Fluid Intake Using a PDA
    Janet Welch; Fiscal Year: 2007
    ..Data from this study will be used in developing a large randomized controlled trial to evaluate the intervention's effectiveness. [unreadable] [unreadable]..
  46. Integrating Interventions to Improve Fecal Incontinence
    John Schnelle; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  47. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  48. Novel Risk Factors for Kidney Stone Formation
    Eric Taylor; Fiscal Year: 2008
    ..At the completion of this career development award, Dr. Taylor will have a unique combination of skills and experience that will enable him to succeed as an independent clinical investigator. ..
  49. In-Home Prevention of SA risks in Native Teen Families
    John T Walkup; Fiscal Year: 2010
    ....
  50. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  51. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
    ..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
  52. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2005
    ....
  53. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  54. Career Development in Pediatric Diabetes at WUMS
    Neil White; Fiscal Year: 2005
    ..The success of this program will be realized as its participants enter the ranks of leadership as physician-scientists in pediatric diabetes over the next decades. ..
  55. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  56. Zinc Neurotoxicity in Traumatic Brain Injury
    Donald Prough; Fiscal Year: 2006
    ..Methodologies: identical to specific aim 1 plus monitoring for signs of neurologic zinc deficiency. ..
  57. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  58. Alcohol Enhances HIV-1 Induced Cardiac Depression
    Kathleen McDonough; Fiscal Year: 2006
    ..The function of the heart will be assessed with the isolated work performing heart and plasma and tissue cytokines and biochemical markers of myocardial oxidative injury and antioxidant capacity will be measured by standard techniques. ..
  59. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
  60. Supplemental Fluid & Collagen Deposition
    Nancy Stotts; Fiscal Year: 2005
    ..Significance: Findings from the study have the potential to significantly change how fluid is managed in nursing home residents and to lay the foundation for a major intervention study on pressure ulcer healing. ..