Genomes and Genes
Summary: Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to water-electrolyte balance. Fluids may be administered intravenously, orally, by intermittent gavage, or by hypodermoclysis.
Publications409 found, 100 shown here
- Early goal-directed therapy in the treatment of severe sepsis and septic shockE Rivers
Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
N Engl J Med 345:1368-77. 2001..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
- Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) GroupRinaldo Bellomo
Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
Crit Care 8:R204-12. 2004..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
- Mortality after fluid bolus in African children with severe infectionKathryn Maitland
Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
N Engl J Med 364:2483-95. 2011..The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established...
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008R Phillip Dellinger
Cooper University Hospital, Camden, NJ, USA
Crit Care Med 36:296-327. 2008..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
- Hydroxyethyl starch or saline for fluid resuscitation in intensive careJohn A Myburgh
Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
N Engl J Med 367:1901-11. 2012..The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported...
- A comparison of albumin and saline for fluid resuscitation in the intensive care unitSimon Finfer
ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
N Engl J Med 350:2247-56. 2004..We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a heterogeneous population of patients in the ICU...
- Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsisAnders Perner
Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
N Engl J Med 367:124-34. 2012..Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis...
- Consensus statement of the ESICM task force on colloid volume therapy in critically ill patientsKonrad Reinhart
Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
Intensive Care Med 38:368-83. 2012....
- Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcomeYong Y Han
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pediatrics 112:793-9. 2003..The objective of this study was to determine whether early septic shock reversal and use of resuscitation practice consistent with the new ACCM-PALS Guidelines by community physicians is associated with improved outcome...
- Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortalityJohn H Boyd
University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Crit Care Med 39:259-65. 2011..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
- Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgeryH G Wakeling
Department of Anaesthesia, Worthing Hospital, Lyndhurst Road, Worthing BN11 2DH, UK
Br J Anaesth 95:634-42. 2005..We assessed whether using intraoperative oesophageal Doppler guided fluid management to minimize hypovolaemia would reduce postoperative hospital stay and the time before return of gut function after colorectal surgery...
- Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjectsAnand Kumar
Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
Crit Care Med 32:691-9. 2004....
- Assessing fluid responsiveness in critically ill patients: False-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricleYazine Mahjoub
Medical YM, CP, AF, El, Ft, CG, HD and Surgical Intensive Care Unit EZ, Department of Anesthesia and Intensive Care, Amiens University Hospital, Amiens, France
Crit Care Med 37:2570-5. 2009..Pulse pressure variation is used to predict fluid responsiveness in mechanically ventilated patients. However, this parameter has been reported to be falsely positive, especially in patients with right ventricular dysfunction...
- Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trialBirgitte Brandstrup
Clinical Unit of Preventive Medicine and Health Promotion, H S Bispebjerg University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
Ann Surg 238:641-8. 2003..To investigate the effect of a restricted intravenous fluid regimen versus a standard regimen on complications after colorectal resection...
- The respiratory variation in inferior vena cava diameter as a guide to fluid therapyMarc Feissel
Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
Intensive Care Med 30:1834-7. 2004..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
- Passive leg raising predicts fluid responsiveness in the critically illXavier Monnet
Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
Crit Care Med 34:1402-7. 2006..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
- Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shockM Feissel
, Centre Hospitalier, Belfort, France
Chest 119:867-73. 2001....
- Comparison of three fluid solutions for resuscitation in dengue shock syndromeBridget A Wills
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
N Engl J Med 353:877-89. 2005..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
- Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fracturesR Venn
Department of Anaesthesia and Intensive Care, Worthing Hospital, W Sussex UK
Br J Anaesth 88:65-71. 2002..conventional intraoperative fluid management with two differing methods of invasive haemodynamic monitoring to optimize intraoperative fluid therapy, in patients undergoing proximal femoral fracture repair under general anaesthesia.
- Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotensionB Tavernier
Department of Anesthesia 2, University Hospital, Lille, France
Anesthesiology 89:1313-21. 1998....
- Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized studyJan Benes
Department of Anesthesiology and Intensive Care, Charles University Teaching Hospital, Alej Svobody 80, Plzen 304 60, Czech Republic
Crit Care 14:R118. 2010..variation (SVV) is a good and easily obtainable predictor of fluid responsiveness, which can be used to guide fluid therapy in mechanically ventilated patients...
- The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertensionYazine Mahjoub
Medical and Surgical Intensive Care Unit, Department of Anesthesia and Intensive Care, Amiens University Medical Center, Amiens, France
Crit Care Med 38:1824-9. 2010..The aim of the present study was to determine whether intra-abdominal hypertension (which impairs venous return) reduces the ability of passive leg raising to detect fluid responsiveness in critically ill ventilated patients...
- Saline or albumin for fluid resuscitation in patients with traumatic brain injuryJohn Myburgh
ANZICS Clinical Trials Group, Level 3, 10 Ievers Terrace, Carlton, VIC 3053, Australia
N Engl J Med 357:874-84. 2007..We conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study...
- Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care unitsSimon Finfer
Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
Crit Care 14:R185. 2010..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
- Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven maresPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
Chest 134:172-8. 2008Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed.
- American Burn Association practice guidelines burn shock resuscitationTam N Pham
University of Washington Burn Center, Seattle, Washington 98104, USA
J Burn Care Res 29:257-66. 2008
- Colloids versus crystalloids for fluid resuscitation in critically ill patientsPablo Perel
Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
Cochrane Database Syst Rev 6:CD000567. 2012..Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids...
- A rational approach to perioperative fluid managementDaniel Chappell
Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
Anesthesiology 109:723-40. 2008..Therefore, undifferentiated fluid handling may increase the shift toward the interstitial space. Using the right kind of fluid in appropriate amounts at the right time might improve patient outcome...
- Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot studyMarc Jacques Dubois
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
Crit Care Med 34:2536-40. 2006..To test the hypothesis that administration of albumin to correct hypoalbuminemia might have beneficial effects on organ function in a mixed population of critically ill patients...
- Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysisDavid J Gattas
Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
Anesth Analg 114:159-69. 2012..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
- Examining the use of oral rehydration salts and other oral rehydration therapy for childhood diarrhea in KenyaLauren S Blum
Am J Trop Med Hyg 85:1126-33. 2011..Health communication is needed to clarify the function of ORT in preventing dehydration...
- Restrictive strategy of intraoperative fluid maintenance during optimization of oxygen delivery decreases major complications after high-risk surgerySuzana M Lobo
Division of Intensive Care, Department of Internal Medicine, Faculdade de Medicina de Sao Jose do Rio Preto, Av Faria Lima 5544, Sao Jose do Rio Preto, CEP 15090 000, Brazil
Crit Care 15:R226. 2011..We evaluated the effects of a restrictive versus conventional strategy of crystalloid administration during goal-directed therapy in high-risk surgical patients...
- Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variationBodin Khwannimit
Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
Eur J Anaesthesiol 29:64-9. 2012....
- Totem and taboo: fluids in sepsisAndrew K Hilton
Department of Intensive Care, Alfred Hospital, Commercial Road, Melbourne, Australia, Victoria 3181, Australia
Crit Care 15:164. 2011....
- Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patientsDaniel A Reuter
Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Intensive Care Med 29:476-80. 2003..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
- Monitoring intravascular volumes for postoperative volume therapyH Brock
General Hospital, Department of Anaesthesia and Intensive Care Medicine, Linz, Austria
Eur J Anaesthesiol 19:288-94. 2002..The feasibility of monitoring measured intravascular volumes and the cardiac filling pressures were compared to reflect the optimal volume status of postoperative patients...
- Clinical practice. Acute infectious diarrheaNathan M Thielman
Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA
N Engl J Med 350:38-47. 2004
- A balanced view of balanced solutionsBertrand Guidet
INSERM, Unité de Recherche en Épidémiologie Systèmes d Information et Modélisation U707, Paris F 75012, France
Crit Care 14:325. 2010The present review of fluid therapy studies using balanced solutions versus isotonic saline fluids (both crystalloids and colloids) aims to address recent controversy in this topic...
- Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigsKarl H Stadlbauer
Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
Anesthesiology 98:699-704. 2003..The authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs...
- Community case management of childhood diarrhea in a setting with declining use of oral rehydration therapy: findings from cross-sectional studies among primary household caregivers, Kenya, 2007Christine K Olson
Epidemic Intelligence Service and Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
Am J Trop Med Hyg 85:1134-40. 2011..Health workers have a critical role in empowering caregivers regarding early treatment with ORT and continued feeding. Increasing community ORS availability is essential to improving diarrhea management...
- The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategiesBryan A Cotton
Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Shock 26:115-21. 2006..Future resuscitation research is likely to focus on improvements in fluid composition and adjuncts to administration of large volume of fluid...
- Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressureChung Chi Huang
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
Crit Care Med 36:2810-6. 2008....
- Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studiesFabio Cavallaro
Department of Anesthesiology and Intensive Care, Intensive Care Unit, Catholic University School of Medicine, Agostino Gemelli Hospital, Rome, Italy
Intensive Care Med 36:1475-83. 2010..To systematically review the published evidence on the ability of passive leg raising-induced changes in cardiac output (PLR-cCO) and in arterial pulse pressure (PLR-cPP) to predict fluid responsiveness...
- A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancerChun Kheng Khoo
Department of Surgery, Musgrove Park Hospital, Taunton and Somerset NHS Trust, Taunton, UK
Ann Surg 245:867-72. 2007..A prospective randomized controlled trial (RCT) of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer...
- Severe hypoxemic respiratory failure: part 2--nonventilatory strategiesSuhail Raoof
Division of Pulmonary and Critical Care Medicine, New York Methodist Hospital, 506 Sixth St, Brooklyn, NY 11215, USA
Chest 137:1437-48. 2010..These interventions may be considered for use, particularly for cases of refractory severe hypoxemia, with proper appreciation of potential costs and adverse effects...
- Diarrhoea case management in low- and middle-income countries--an unfinished agendaBirger Carl Forsberg
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
Bull World Health Organ 85:42-8. 2007..To ascertain whether diarrhoea management improved during 1986-2003, a period when significant efforts were made to promote effective case management in children...
- Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical studyMoritz Wyler von Ballmoos
Department of Intensive Care Medicine, Bern University Hospital and University of Bern Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
Crit Care 14:R111. 2010..We aimed to assess prediction of volume responsiveness with PPV in patients with increased pulmonary artery pressure...
- Home management of diarrhea among underfives in a rural community in Kenya: household perceptions and practicesDoreen M Othero
Maseno University, School of Public Health and Community Development, Private Bag, Maseno Kenya
East Afr J Public Health 5:142-6. 2008..Home management of diarrhea is one of the key household practices targeted for enhancement in the Community Integrated Management of Childhood Illness (C-IMCI) strategy...
- Fluid resuscitation: past, present, and the futureHeena P Santry
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Shock 33:229-41. 2010..Thus, we describe how some novel resuscitation strategies aimed at preventing or ameliorating cellular injury may become clinically available in the future...
- Cardiovascular management of septic shockR Phillip Dellinger
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
Crit Care Med 31:946-55. 2003
- Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemiaRonald J Trof
Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
Intensive Care Med 36:697-701. 2010..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
- Progress and barriers for the control of diarrhoeal diseaseMathuram Santosham
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet 376:63-7. 2010....
- Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: a clinical, prospective, randomized, controlled studyA Egge
Department of Neurosurgery, , Norway
Neurosurgery 49:593-605; discussion 605-6. 2001OBJECTIVE: To investigate the role of prophylactic hyperdynamic postoperative fluid therapy in preventing delayed ischemic neurological deficits attributable to cerebral vasospasm...
- Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsisG Marx
University of Liverpool, University Department of Anaesthesia, Liverpool, UK
Eur J Anaesthesiol 21:132-8. 2004..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
- Comparison of two fluid-management strategies in acute lung injuryHerbert P Wiedemann
Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
N Engl J Med 354:2564-75. 2006..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
- Assessing fluid responsiveness during open chest conditionsD A Reuter
Department of Anaesthesiology, University of Munich, 81377 Munich, Germany
Br J Anaesth 94:318-23. 2005..The aim of this study was to investigate the ability of SVV and PPV measured by arterial pulse contour analysis to assess fluid responsiveness in patients undergoing coronary artery bypass surgery during open-chest conditions...
- How the cholera epidemic of 1831 resulted in a new technique for fluid resuscitationB A Foex
Manchester Royal Infirmary, Oxford Road, Manchester, UK
Emerg Med J 20:316-8. 2003
- A pilot test of the addition of zinc to the current case management package of diarrhea in a primary health care settingNita Bhandari
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
J Pediatr Gastroenterol Nutr 41:685-7. 2005..Reduction in use of drugs during diarrhea ranged from 34% for tablets to 64% for injections 6 months later. The cost of treatment to families declined significantly. These findings need confirmation in a randomized controlled trial...
- Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?Michael C Madigan
Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 64:280-5. 2008..We hypothesized that poor resuscitation techniques, including early and excessive crystalloid administration, places patients with extremity injuries at risk for developing secondary ACS...
- Haemostatic resuscitationR P Dutton
Department of Anesthesia and Critical Care, University of Chicago, Anesthesia Quality Institute 520 N Northwest Highway, Park Ridge, IL 60068, USA
Br J Anaesth 109:i39-i46. 2012..Future directions for resuscitation research are discussed...
- Use of deferred consent for severely ill children in a multi-centre phase III trialKathryn Maitland
Kemri Wellcome Centre for Geographic medicine, Coast, Kenya
Trials 12:90. 2011..Across Europe and the United States stringent regulations have resulted in a substantial decline of clinical trials involving emergency interventions...
- Hydroxyethyl starch - the importance of being earnestDaniel Chappell
Department of Anaesthesiology, University Hospital of Munich, Nussbaumstrasse 20, 80336 Munich, Germany
Scand J Trauma Resusc Emerg Med 21:61. 2013..An authority being able to dictate behavior should stand clear from oppressively ending a worldwide expert discussion and step back into the role of the observer until science achieves an agreement...
- Variation of left ventricular outflow tract velocity and global end-diastolic volume index reliably predict fluid responsiveness in cardiac surgery patientsOle Broch
Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
J Crit Care 27:325.e7-13. 2012..The aim of the present study was to challenge the predictive power of GEDVI and ΔVTI(LVOT) compared with pulse pressure variation (PPV) and stroke volume variation (SVV) in a large patient population...
- Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgeryC Challand
Directorate of Gastroenterology, Theatres and Pain, Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth PL6 8DH, UK
Br J Anaesth 108:53-62. 2012Intraoperative fluid therapy regimens using oesophageal Doppler monitoring (ODM) to optimize stroke volume (SV) (goal-directed fluid therapy, GDT) have been associated with a reduction in length of stay (LOS) and complication rates after ..
- Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) studySimon Finfer
Australian and New Zealand Intensive Care Society Clinical Trials Group, Carlton, VIC 3053, Australia
BMJ 333:1044. 2006..To determine whether outcomes of resuscitation with albumin or saline in the intensive care unit depend on patients' baseline serum albumin concentration...
- Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trialAlan E Jones
Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
JAMA 303:739-46. 2010..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
- Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre studyThomas W L Scheeren
Department of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
J Clin Monit Comput 27:225-33. 2013..Our findings also suggest that a goal-directed strategy might decrease postoperative organ dysfunction...
- Management of gastroenteritis over 10 years: changing culture and maintaining the changeJoanne Fox
Department of Child Health, Children s Hospital for Wales, Heath Park, Cardiff, UK
Arch Dis Child 97:415-7. 2012..To examine the impact of an implementation program on adherence to a guideline for the management of acute gastroenteritis...
- Zinc and low osmolarity oral rehydration salts for diarrhoea: a renewed call to actionChrista L Fischer Walker
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Bull World Health Organ 87:780-6. 2009..Revitalizing diarrhoea management must become an international priority if we are going to reduce the burden of diarrhoea deaths and overall child mortality around the world...
- Safety of gelatin for volume resuscitation--a systematic review and meta-analysisD O Thomas-Rueddel
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
Intensive Care Med 38:1134-42. 2012..Gelatin is frequently used as a volume expander in critical care. Our goal was to investigate its safety...
- Operational issues and trends associated with the pilot introduction of zinc for childhood diarrhoea in Bougouni district, MaliPeter J Winch
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2103, USA
J Health Popul Nutr 26:151-62. 2008....
- Practice and attitudes regarding the management of childhood diarrhoea among pharmacies in ThailandWoranuch Saengcharoen
Department of Clinical Pharmacy and Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand
Int J Pharm Pract 18:323-31. 2010....
- Adjunctive management of malariaSanjeev Krishna
Division of Clinical Sciences, Centre for Infection and Immunity, St George s University of London, London, UK
Curr Opin Infect Dis 25:484-8. 2012..Identifying new adjunct approaches has been particularly difficult for severe malaria because most interventions have either caused harm or failed to confer benefit...
- Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac functionDaniel A Reuter
Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
Crit Care Med 31:1399-404. 2003..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
- Cardiac filling volumes versus pressures for predicting fluid responsiveness after cardiovascular surgery: the role of systolic cardiac functionRonald J Trof
Vrije Universiteit Medical Centre, Department of Intensive Care, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Crit Care 15:R73. 2011....
- Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sensePaul E Marik
Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
Crit Care Med 41:1774-81. 2013..Despite a previous meta-analysis that concluded that central venous pressure should not be used to make clinical decisions regarding fluid management, central venous pressure continues to be recommended for this purpose...
- Initial fluid resuscitation of patients with septic shock in the intensive care unitS Carlsen
Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Acta Anaesthesiol Scand 55:394-400. 2011..Our aim was to evaluate the current initial fluid resuscitation practice in patients with septic shock in the intensive care unit (ICU) and patient characteristics and outcome associated with fluid volume...
- Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparisonOle Bayer
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
Crit Care Med 39:1335-42. 2011..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury.
- The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patientsCyril Charron
Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
Anesth Analg 102:1511-7. 2006..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
- Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgeryH Berkenstadt
Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
Anesth Analg 92:984-9. 2001..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
- Fluid resuscitation strategies: a systematic review of animal trialsJames Mapstone
Public Health Medicine, Castle Point and Rochford Primary Care Trust, Rayleigh, Essex, United Kingdom
J Trauma 55:571-89. 2003..Our objective was to systematically review randomized, controlled trials of fluid resuscitation in animal models of uncontrolled hemorrhage and to explore potential sources of heterogeneity...
- Effects of albumin 5% and artificial colloids on clot formation in small infantsT Haas
Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Anaesthesia 62:1000-7. 2007..From a haemostatic point of view it might be preferable to use gelatine solution as an alternative to albumin; HES showed the greatest effects on the overall coagulation process...
- Fluid intake and decreased risk for hospitalization for dengue fever, NicaraguaEva Harris
University of California, Berkeley, California 94720 6350, USA
Emerg Infect Dis 9:1003-6. 2003..Similar results were obtained for children <15 years of age and older adolescents and adults in independent analyses...
- Dynamic indices do not predict volume responsiveness in routine clinical practiceB Lansdorp
MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
Br J Anaesth 108:395-401. 2012....
- The importance of fluid management in acute lung injury secondary to septic shockClaire V Murphy
Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
Chest 136:102-9. 2009..Because these may be seen as potentially conflicting practices, we set out to determine the influence of fluid management on the outcomes of patients with septic shock complicated by ALI...
- Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colonOliver Kimberger
Department of Anesthesiology and Pain Therapy, Inselspital University Hospital Bern, Switzerland
Anesthesiology 110:496-504. 2009The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon ..
- Dopexamine has no additional benefit in high-risk patients receiving goal-directed fluid therapy undergoing major abdominal surgerySimon J Davies
Department of Anaesthesia, York Teaching Hospitals NHS Foundation Trust, North Yorkshire, United Kingdom
Anesth Analg 112:130-8. 2011..In this study, we assessed the effects of low-dose dopexamine on morbidity after major abdominal surgery in patients who were at increased risk by virtue of a reduced AT...
- Dynamic preload indicators fail to predict fluid responsiveness in open-chest conditionsEric E C de Waal
Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
Crit Care Med 37:510-5. 2009..However, in open-chest conditions, the value of these indices has not been systematically examined yet. We, therefore, evaluated the ability of PPV and SVV to predict fluid responsiveness under open- and closed-chest conditions...
- A critique of fluid bolus resuscitation in severe sepsisAndrew K Hilton
Department of Intensive Care, Alfred Hospital, and Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
Crit Care 16:302. 2012..In the present article, we contend that the concept of large fluid bolus resuscitation in sepsis needs to be investigated further...
- Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a "gray zone" approachMaxime Cannesson
Department of Anesthesiology and Perioperative Care, School of Medicine, University of California, Irvine, Irvine, California, USA
Anesthesiology 115:231-41. 2011..The authors sought to test the predictive value of PPV in a large, multicenter study and to express it using a gray zone approach...
- Errors in fluid therapy in medical wardsMaryam Mousavi
Tehran University of Medical Sciences, Tehran, Iran
Int J Clin Pharm 34:374-81. 2012Intravenous fluid therapy remains an essential part of patients' care during hospitalization...
- Supplemental perioperative fluid administration increases tissue oxygen pressureCem F Arkilic
Department of Anesthesiology, Section of Colon and Rectal Surgery, Washington University, St Louis, MO, USA
Surgery 133:49-55. 2003..We tested the hypothesis that supplemental fluid administration during and after elective colon resection increases tissue perfusion and tissue oxygen pressure...
- Perioperative monitoring of fluid responsiveness after esophageal surgery using stroke volume variationMakoto Kobayashi
Surgical Division, Hakodate Goryoukaku Hospital, 38 3 Goryoukaku cho, Hakodate City, Hokkaido, Japan
Expert Rev Med Devices 5:311-6. 2008..To assess the utility of a new arterial pressure-based cardiac output (FloTrac) and central venous oximetry (PreSep) monitoring system in the perioperative management of patients undergoing radical esophagectomy...
- Determinants of use rate of oral rehydration therapy for management of childhood diarrhoea in rural BangladeshM Ali
Department of General Practice, University of Western Australia, Fremantle Hospital, Australia
J Health Popul Nutr 18:103-8. 2000..Promotion of ORT can be effected by improving the level of understanding of mothers with regard to assessment of severity, early initiation of treatment regardless of age, sex, type of diarrhoea, breast-feeding, and nutrition status...
- The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a reviewJoachim Boldt
Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen, Germany
Intensive Care Med 36:1299-308. 2010..This review presents the (patho)physiological basis of hypovolemia, microcirculation, and tissue oxygenation and presents a literature review on the effects of plasma substitutes on microperfusion and oxygenation in the clinical setting...
- Physiological effects of hyperchloraemia and acidosisJ M Handy
Chelsea and Westminster NHS Foundation Trust, Imperial College London, 369 Fulham Road, London SW10 9NH, UK
Br J Anaesth 101:141-50. 2008..It is intended to provide an assessment of the importance of hyperchloraemic acidosis and thereby the likely benefits of balanced solutions...
- The Parkland formula under fire: is the criticism justified?Jennifer Blumetti
University of Texas Southwestern, Dallas, Texas, USA
J Burn Care Res 29:180-6. 2008..The Parkland formula only represents a resuscitation "starting" point. The UOP is the important parameter...
- Arterial versus plethysmographic dynamic indices to test responsiveness for testing fluid administration in hypotensive patients: a clinical trialGiuseppe Natalini
Department of Anesthesiology, Intensive Care Medicine and Emergency Medicine, Poliambulanza Foundation Hospital, Brescia, Italy
Anesth Analg 103:1478-84. 2006..These plethysmographic indices could provide a noninvasive tool for predicting the cardiac output increase by administering fluid...
- Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine modelJochen Renner
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
Crit Care Med 37:650-8. 2009..Therefore, the present study was designed to evaluate whether PPV and SVV are suitable for predicting fluid responsiveness during elevated IAP...
- Safety of rapid intravenous rehydration and comparative efficacy of 3 oral rehydration solutions in the treatment of severely malnourished children with dehydrating choleraNur H Alam
Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
J Pediatr Gastroenterol Nutr 48:318-27. 2009..Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions...
- Predicting increased fluid requirements during the resuscitation of thermally injured patientsLeopoldo C Cancio
US Army Institute of Surgical Research, Charleston, South Carolina, USA
J Trauma 56:404-13; discussion 413-4. 2004....
- Assessment of Dehydration in Children with Diarrhea in Resource-Limited SettingsADAM CARL LEVINE; Fiscal Year: 2013....
- The role of prophage life cycle in Stx production and disease due to EHECKathryn A Eaton; Fiscal Year: 2013..When HUS does occur, it is often after recovery from the diarrheic phase. Intensive fluid therapy instituted at the time of EHEC diagnosis has shown to be somewhat protective against HUS development, but ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTErnest M Wright; Fiscal Year: 2013..g. the Na/iodide and SGLT2, and the structurally related serotonin reuptake transporter (SERT) in brain and enteric nervous systems. ..
- Fluid Therapy and Cerebral Injury in Pediatric Diabetic KetoacidosisNathan Kuppermann; Fiscal Year: 2013..The relationship of fluid therapy for DKA and risk of cerebral injury and cerebral edema is not well understood and has been debated for decades...
- Probiotics in Pediatric Diarrhea in Peru_SupplementRichard A Oberhelman; Fiscal Year: 2012....
- Investigation of Effective Training of "promotoras" in Oral Rehydration TherapyRACHEL ANN HALL-CLIFFORD; Fiscal Year: 2013..These results are expected to have an important positive impact by improving the efficacy and sustainability of ORT education campaigns through encouraging local collaboration and ownership of program content. ..
- Cellular Molecular Mechanisms of Alanyl-Glutamine Oral Rehydration and NutritionSEAN RYAN MOORE; Fiscal Year: 2013..Furthermore, this outstanding training opportunity will provide me with the foundation necessary for a successful career as an independent global health scientist. ..
- Identification of novel inhibitors of a Vibrio cholerae stress response pathwayJyl S Matson; Fiscal Year: 2013..cholerae colonization in an animal model of disease will have been identified. This contribution will be significant because it is the first step toward the development of new and fundamentally different therapeutics for cholera. ..
- Bedside Monitor to Quantify Cardiac Shunt Flow in Newborns and Small ChildrenNikolai M Krivitski; Fiscal Year: 2012..Timely and accurate quantitative assessment of Qp/Qs permits successful pharmacologic, ventilator or fluid therapy or in time surgical intervention...
- Probiotics for Infectious Diarrhea in Children in South IndiaHonorine Ward; Fiscal Year: 2009..These studies are important to help understand whether and how probiotics work in protecting and healing the intestine. ..
- INTRAVENOUS FLUID THERAPY AND HEAD INJURYSteven Shackford; Fiscal Year: 1990..Intravenous fluid therapy is necessary in all of these patients, especially those who require resuscitation from hypovolemic shock...
- PROBIOTICS IN PEDIATRIC DIARRHEA IN PERU: PLANNING GRANTRichard Oberhelman; Fiscal Year: 2006..Support for these activities during a planning period before the clinical trial will greatly facilitate the implementation of the trial. ..
- RESISTANT STARCH: ADJUNCT TO ORAL REHYDRATION SOLUTIONHENRY BINDER; Fiscal Year: 2000..Treatment failures will be categorized and recorded. If resistant starch is found to reduce fecal volumes and/or duration of diarrhea, this innovative therapy must then be tested in the community for acceptance. ..
- Alanyl-glutamine as Oral Rehydration & Nutrition TherapyGERLY BRITO; Fiscal Year: 2001..proposed commercial application: not available ..
- MECHANISMS OF INTESTINAL CELL MIGRATIONJON RHOADS; Fiscal Year: 2001..Active growth peptides in serum will be identified and quantified. We will determine if ARG potentiates serum growth factor signaling or activates separate signaling pathways during migration. ..
- MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 2005..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
- Cerebral edema in pediatric ketoacidosisNicole Glaser; Fiscal Year: 2009..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
- PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURERavindra Mehta; Fiscal Year: 2001..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
- The Effect of Hypertonic Resuscitation for Blunt TraumaEileen Bulger; Fiscal Year: 2005..abstract_text> ..
- Biological Markers of Recovery for the KidneyJohn A Kellum; Fiscal Year: 2010..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
- Hypertonic Modulation of Inflammation following InjuryEileen M Bulger; Fiscal Year: 2010..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
- Systems Engineering of Pheresis Intervention for SepsisJohn Kellum; Fiscal Year: 2009..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
- Quantifying Left Ventricular Ejection EffectivenessMichael Pinsky; Fiscal Year: 2007..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..
- APOE and the Effects of Malnutrition on Cognitive and Intestinal DevelopmentRichard L Guerrant; Fiscal Year: 2010..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
- Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled TrialEduardo Bruera; Fiscal Year: 2009..In this study, we will test if giving fluid through the vein will improve the symptoms, delay confusion and prolong life in patients who are no longer to drink at the end of life. ..
- Methylphenidate for Fatigue in Advanced Cancer PatientsEduardo Bruera; Fiscal Year: 2009....
- Morphine versus Methadone as First Line Strong Opioid for Cancer PainEduardo Bruera; Fiscal Year: 2009..Relevance to Public Health: In this study, we will test if methadone is better than morphine in cancer pain control, quality of life, and is more cost-effective. ..
- COLONIC CRYPT CELL FUNCTIONHENRY BINDER; Fiscal Year: 2001..We plan to establish the cellular model and the regulatory control of agonist-induced colonic bicarbonate secretion. These studies should define the cellular mechanisms of Na/C1/HCO/3 absorption and secretion in the colonic crypt. ..
- Colonic Crypt HCO3 SecretionHENRY BINDER; Fiscal Year: 2006..e., cNBC) differs substantially from other NBCs and may represent a novel epithelial cell NBC. We propose comprehensive transport, electrophysiological and molecular studies to characterize crypt HCO3 secretion. ..
- Socioeconomic and Ethnic Disparities in Adult HealthNarayan Sastry; Fiscal Year: 2008..L.A.FANS-2/Adult data will publicly released as quickly as possible once fieldwork is complete, to enable a wide range of researchers to conduct research. ..
- IMMUNE RESPONSES TO PNEUMOCOCCAL ANTIGENS IN CHILDRENLisa Kobrynski; Fiscal Year: 2003..In addition, the applicant will pursue further training in study design and research methods, including didactic courses at the Rollins School of Public Health and the Graduate Division of Biological and Biomedical Sciences, at Emory. ..
- Dynamics of Peritoneal Dialysis Associated PeritonitisJohn Hotchkiss; Fiscal Year: 2004..Prolonged courses of antibiotic therapy required by compromised host defenses may render the dialysis population an effective "incubator" for drug resistant microorganisms. ..
- BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIAMyron Levine; Fiscal Year: 2004..falciparum, and by these effects working in concert, we will ultimately be able to prevent disease completely in some subjects and to markedly ameliorate disease severity in others. ..
- Models of Birthweight and Low BirthweightNarayan Sastry; Fiscal Year: 2004..The first is the 1997 Natality Data Set (NDS), compiled from birth certificates by the National Center for Health Statistics. The second data source is the 1988 National Maternal and Infant Health Survey (NMIHS). ..
- Calcium Signaling in Developing Intestinal EpitheliumMrinalini Rao; Fiscal Year: 2005....
- Homicide During Robbery: A Case-Control StudyStephen Marshall; Fiscal Year: 2004..The results of this study will assist in targeting prevention resources to specific high-risk workplaces and neighborhoods. ..
- Causal Analysis of Encouragement Design StudiesXiao Hua Zhou; Fiscal Year: 2004..In this proposal, we will develop a general statistical methodology for causal treatment analysis of the randomized EDS when data have a complicated structure. ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- MRS Detects Metabolic Dysfunction after Brain InjuryPaul Vespa; Fiscal Year: 2009..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
- Post Traumatic Nonconvulsive Epileptiform ActivityPaul Vespa; Fiscal Year: 2005..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
- SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLSPatricia Chess; Fiscal Year: 2003..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..
- Continuation of Dialysis Access Consortium Clinical TrialsJonathan Himmelfarb; Fiscal Year: 2007..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..
- Chronic Alcohol & AIDS Impact on Muscle WastingPatricia Molina; Fiscal Year: 2006..abstract_text> ..
- Hypertrophic Scarring After Partial-Thickness WoundsLOREN ENGRAV; Fiscal Year: 2006..We will laser capture microdissect cones from shallow and deep partial-thickness Duroc wounds, extract and amplify the mRNA, and perform porcine DNA array analysis to determine which genes are differentially expressed. ..
- Self Monitoring of Dietary and Fluid Intake Using a PDAJanet Welch; Fiscal Year: 2007..Data from this study will be used in developing a large randomized controlled trial to evaluate the intervention's effectiveness. [unreadable] [unreadable]..
- Integrating Interventions to Improve Fecal IncontinenceJohn Schnelle; Fiscal Year: 2008..unreadable] [unreadable]..
- REGULATION OF HUMAN ALDOSTERONE SYNTHASEPerrin White; Fiscal Year: 2002..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
- Novel Risk Factors for Kidney Stone FormationEric Taylor; Fiscal Year: 2008..At the completion of this career development award, Dr. Taylor will have a unique combination of skills and experience that will enable him to succeed as an independent clinical investigator. ..
- In-Home Prevention of SA risks in Native Teen FamiliesJohn T Walkup; Fiscal Year: 2010....
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- Alcoholism and Disease: Immune /Pathological MechanismsPatricia Molina; Fiscal Year: 2002..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
- RESOLUTION OF CLINICAL LUNG INJURYMichael Matthay; Fiscal Year: 2005....
- Biochemical Basis of Cortisone Reductase DeficiencyPerrin White; Fiscal Year: 2007..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
- Career Development in Pediatric Diabetes at WUMSNeil White; Fiscal Year: 2005..The success of this program will be realized as its participants enter the ranks of leadership as physician-scientists in pediatric diabetes over the next decades. ..
- Cannabinoid effects on HIV/AIDSPatricia E Molina; Fiscal Year: 2010....
- Zinc Neurotoxicity in Traumatic Brain InjuryDonald Prough; Fiscal Year: 2006..Methodologies: identical to specific aim 1 plus monitoring for signs of neurologic zinc deficiency. ..
- Induced hypothermic arrest in traumatic shockHasan Alam; Fiscal Year: 2005..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
- Alcohol Enhances HIV-1 Induced Cardiac DepressionKathleen McDonough; Fiscal Year: 2006..The function of the heart will be assessed with the isolated work performing heart and plasma and tissue cytokines and biochemical markers of myocardial oxidative injury and antioxidant capacity will be measured by standard techniques. ..
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher P Duggan; Fiscal Year: 2010..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
- Supplemental Fluid & Collagen DepositionNancy Stotts; Fiscal Year: 2005..Significance: Findings from the study have the potential to significantly change how fluid is managed in nursing home residents and to lay the foundation for a major intervention study on pressure ulcer healing. ..