fluid therapy

Summary

Summary: Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to water-electrolyte balance. Fluids may be administered intravenously, orally, by intermittent gavage, or by hypodermoclysis.

Top Publications

  1. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
  2. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  3. doi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
  4. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  5. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
  6. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
  7. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
  8. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
  9. ncbi Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery
    H G Wakeling
    Department of Anaesthesia, Worthing Hospital, Lyndhurst Road, Worthing BN11 2DH, UK
    Br J Anaesth 95:634-42. 2005
  10. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005

Detail Information

Publications376 found, 100 shown here

  1. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
  2. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  3. doi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
    ..The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established...
  4. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  5. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
    ..Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis...
  6. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  7. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
    ..The objective of this study was to determine whether early septic shock reversal and use of resuscitation practice consistent with the new ACCM-PALS Guidelines by community physicians is associated with improved outcome...
  8. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  9. ncbi Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery
    H G Wakeling
    Department of Anaesthesia, Worthing Hospital, Lyndhurst Road, Worthing BN11 2DH, UK
    Br J Anaesth 95:634-42. 2005
    ..We assessed whether using intraoperative oesophageal Doppler guided fluid management to minimize hypovolaemia would reduce postoperative hospital stay and the time before return of gut function after colorectal surgery...
  10. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  11. pmc Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial
    Birgitte Brandstrup
    Clinical Unit of Preventive Medicine and Health Promotion, H S Bispebjerg University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Ann Surg 238:641-8. 2003
    ..To investigate the effect of a restricted intravenous fluid regimen versus a standard regimen on complications after colorectal resection...
  12. doi Assessing fluid responsiveness in critically ill patients: False-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricle
    Yazine Mahjoub
    Medical YM, CP, AF, El, Ft, CG, HD and Surgical Intensive Care Unit EZ, Department of Anesthesia and Intensive Care, Amiens University Hospital, Amiens, France
    Crit Care Med 37:2570-5. 2009
    ..Pulse pressure variation is used to predict fluid responsiveness in mechanically ventilated patients. However, this parameter has been reported to be falsely positive, especially in patients with right ventricular dysfunction...
  13. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  14. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
    ....
  15. ncbi Passive leg raising predicts fluid responsiveness in the critically ill
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
    Crit Care Med 34:1402-7. 2006
    ..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
  16. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
    ..The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported...
  17. pmc A balanced view of balanced solutions
    Bertrand Guidet
    INSERM, Unité de Recherche en Épidémiologie Systèmes d Information et Modélisation U707, Paris F 75012, France
    Crit Care 14:325. 2010
    The present review of fluid therapy studies using balanced solutions versus isotonic saline fluids (both crystalloids and colloids) aims to address recent controversy in this topic...
  18. pmc Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study
    Jan Benes
    Department of Anesthesiology and Intensive Care, Charles University Teaching Hospital, Alej Svobody 80, Plzen 304 60, Czech Republic
    Crit Care 14:R118. 2010
    ..variation (SVV) is a good and easily obtainable predictor of fluid responsiveness, which can be used to guide fluid therapy in mechanically ventilated patients...
  19. doi The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension
    Yazine Mahjoub
    Medical and Surgical Intensive Care Unit, Department of Anesthesia and Intensive Care, Amiens University Medical Center, Amiens, France
    Crit Care Med 38:1824-9. 2010
    ..The aim of the present study was to determine whether intra-abdominal hypertension (which impairs venous return) reduces the ability of passive leg raising to detect fluid responsiveness in critically ill ventilated patients...
  20. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  21. ncbi Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures
    R Venn
    Department of Anaesthesia and Intensive Care, Worthing Hospital, W Sussex UK
    Br J Anaesth 88:65-71. 2002
    ..conventional intraoperative fluid management with two differing methods of invasive haemodynamic monitoring to optimize intraoperative fluid therapy, in patients undergoing proximal femoral fracture repair under general anaesthesia.
  22. ncbi Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
    Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed.
  23. doi A rational approach to perioperative fluid management
    Daniel Chappell
    Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 109:723-40. 2008
    ..Therefore, undifferentiated fluid handling may increase the shift toward the interstitial space. Using the right kind of fluid in appropriate amounts at the right time might improve patient outcome...
  24. doi American Burn Association practice guidelines burn shock resuscitation
    Tam N Pham
    University of Washington Burn Center, Seattle, Washington 98104, USA
    J Burn Care Res 29:257-66. 2008
  25. pmc Totem and taboo: fluids in sepsis
    Andrew K Hilton
    Department of Intensive Care, Alfred Hospital, Commercial Road, Melbourne, Australia, Victoria 3181, Australia
    Crit Care 15:164. 2011
    ....
  26. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  27. ncbi Saline or albumin for fluid resuscitation in patients with traumatic brain injury
    John Myburgh
    ANZICS Clinical Trials Group, Level 3, 10 Ievers Terrace, Carlton, VIC 3053, Australia
    N Engl J Med 357:874-84. 2007
    ..We conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study...
  28. pmc Use of deferred consent for severely ill children in a multi-centre phase III trial
    Kathryn Maitland
    Kemri Wellcome Centre for Geographic medicine, Coast, Kenya
    Trials 12:90. 2011
    ..Across Europe and the United States stringent regulations have resulted in a substantial decline of clinical trials involving emergency interventions...
  29. ncbi Monitoring intravascular volumes for postoperative volume therapy
    H Brock
    General Hospital, Department of Anaesthesia and Intensive Care Medicine, Linz, Austria
    Eur J Anaesthesiol 19:288-94. 2002
    ..The feasibility of monitoring measured intravascular volumes and the cardiac filling pressures were compared to reflect the optimal volume status of postoperative patients...
  30. pmc A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer
    Chun Kheng Khoo
    Department of Surgery, Musgrove Park Hospital, Taunton and Somerset NHS Trust, Taunton, UK
    Ann Surg 245:867-72. 2007
    ..A prospective randomized controlled trial (RCT) of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer...
  31. doi Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressure
    Chung Chi Huang
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
    Crit Care Med 36:2810-6. 2008
    ....
  32. doi Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  33. pmc Diarrhoea case management in low- and middle-income countries--an unfinished agenda
    Birger Carl Forsberg
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Bull World Health Organ 85:42-8. 2007
    ..To ascertain whether diarrhoea management improved during 1986-2003, a period when significant efforts were made to promote effective case management in children...
  34. doi Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studies
    Fabio Cavallaro
    Department of Anesthesiology and Intensive Care, Intensive Care Unit, Catholic University School of Medicine, Agostino Gemelli Hospital, Rome, Italy
    Intensive Care Med 36:1475-83. 2010
    ..To systematically review the published evidence on the ability of passive leg raising-induced changes in cardiac output (PLR-cCO) and in arterial pulse pressure (PLR-cPP) to predict fluid responsiveness...
  35. ncbi The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies
    Bryan A Cotton
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Shock 26:115-21. 2006
    ..Future resuscitation research is likely to focus on improvements in fluid composition and adjuncts to administration of large volume of fluid...
  36. ncbi Severe hypoxemic respiratory failure: part 2--nonventilatory strategies
    Suhail Raoof
    Division of Pulmonary and Critical Care Medicine, New York Methodist Hospital, 506 Sixth St, Brooklyn, NY 11215, USA
    Chest 137:1437-48. 2010
    ..These interventions may be considered for use, particularly for cases of refractory severe hypoxemia, with proper appreciation of potential costs and adverse effects...
  37. pmc Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study
    Moritz Wyler von Ballmoos
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Crit Care 14:R111. 2010
    ..We aimed to assess prediction of volume responsiveness with PPV in patients with increased pulmonary artery pressure...
  38. ncbi Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: a clinical, prospective, randomized, controlled study
    A Egge
    Department of Neurosurgery, , Norway
    Neurosurgery 49:593-605; discussion 605-6. 2001
    OBJECTIVE: To investigate the role of prophylactic hyperdynamic postoperative fluid therapy in preventing delayed ischemic neurological deficits attributable to cerebral vasospasm...
  39. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  40. ncbi Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?
    Michael C Madigan
    Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:280-5. 2008
    ..We hypothesized that poor resuscitation techniques, including early and excessive crystalloid administration, places patients with extremity injuries at risk for developing secondary ACS...
  41. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  42. doi Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine PEM, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 37:2642-7. 2009
    ..Dynamic changes in systolic pressure, pulse pressure, and stroke volume in patients undergoing mechanical ventilation have emerged as useful techniques to assess volume responsiveness...
  43. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  44. ncbi Assessing fluid responsiveness during open chest conditions
    D A Reuter
    Department of Anaesthesiology, University of Munich, 81377 Munich, Germany
    Br J Anaesth 94:318-23. 2005
    ..The aim of this study was to investigate the ability of SVV and PPV measured by arterial pulse contour analysis to assess fluid responsiveness in patients undergoing coronary artery bypass surgery during open-chest conditions...
  45. doi Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
    ..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients...
  46. doi Initial fluid resuscitation of patients with septic shock in the intensive care unit
    S Carlsen
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 55:394-400. 2011
    ..Our aim was to evaluate the current initial fluid resuscitation practice in patients with septic shock in the intensive care unit (ICU) and patient characteristics and outcome associated with fluid volume...
  47. ncbi The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patients
    Cyril Charron
    Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
    Anesth Analg 102:1511-7. 2006
    ..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
  48. doi Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison
    Ole Bayer
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
    Crit Care Med 39:1335-42. 2011
    ..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury.
  49. pmc Fluid intake and decreased risk for hospitalization for dengue fever, Nicaragua
    Eva Harris
    University of California, Berkeley, California 94720 6350, USA
    Emerg Infect Dis 9:1003-6. 2003
    ..Similar results were obtained for children <15 years of age and older adolescents and adults in independent analyses...
  50. doi The importance of fluid management in acute lung injury secondary to septic shock
    Claire V Murphy
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
    Chest 136:102-9. 2009
    ..Because these may be seen as potentially conflicting practices, we set out to determine the influence of fluid management on the outcomes of patients with septic shock complicated by ALI...
  51. ncbi Effects of albumin 5% and artificial colloids on clot formation in small infants
    T Haas
    Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anaesthesia 62:1000-7. 2007
    ..From a haemostatic point of view it might be preferable to use gelatine solution as an alternative to albumin; HES showed the greatest effects on the overall coagulation process...
  52. pmc Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
    Ronald J Trof
    Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
    Intensive Care Med 36:697-701. 2010
    ..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
  53. ncbi Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery
    H Berkenstadt
    Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Anesth Analg 92:984-9. 2001
    ..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
  54. ncbi Fluid resuscitation strategies: a systematic review of animal trials
    James Mapstone
    Public Health Medicine, Castle Point and Rochford Primary Care Trust, Rayleigh, Essex, United Kingdom
    J Trauma 55:571-89. 2003
    ..Our objective was to systematically review randomized, controlled trials of fluid resuscitation in animal models of uncontrolled hemorrhage and to explore potential sources of heterogeneity...
  55. doi Dynamic indices do not predict volume responsiveness in routine clinical practice
    B Lansdorp
    MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    Br J Anaesth 108:395-401. 2012
    ....
  56. ncbi Supplemental perioperative fluid administration increases tissue oxygen pressure
    Cem F Arkilic
    Department of Anesthesiology, Section of Colon and Rectal Surgery, Washington University, St Louis, MO, USA
    Surgery 133:49-55. 2003
    ..We tested the hypothesis that supplemental fluid administration during and after elective colon resection increases tissue perfusion and tissue oxygen pressure...
  57. doi Dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    Crit Care Med 37:510-5. 2009
    ..However, in open-chest conditions, the value of these indices has not been systematically examined yet. We, therefore, evaluated the ability of PPV and SVV to predict fluid responsiveness under open- and closed-chest conditions...
  58. ncbi Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon
    Oliver Kimberger
    Department of Anesthesiology and Pain Therapy, Inselspital University Hospital Bern, Switzerland
    Anesthesiology 110:496-504. 2009
    The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon ..
  59. doi Dopexamine has no additional benefit in high-risk patients receiving goal-directed fluid therapy undergoing major abdominal surgery
    Simon J Davies
    Department of Anaesthesia, York Teaching Hospitals NHS Foundation Trust, North Yorkshire, United Kingdom
    Anesth Analg 112:130-8. 2011
    ..In this study, we assessed the effects of low-dose dopexamine on morbidity after major abdominal surgery in patients who were at increased risk by virtue of a reduced AT...
  60. ncbi Perioperative monitoring of fluid responsiveness after esophageal surgery using stroke volume variation
    Makoto Kobayashi
    Surgical Division, Hakodate Goryoukaku Hospital, 38 3 Goryoukaku cho, Hakodate City, Hokkaido, Japan
    Expert Rev Med Devices 5:311-6. 2008
    ..To assess the utility of a new arterial pressure-based cardiac output (FloTrac) and central venous oximetry (PreSep) monitoring system in the perioperative management of patients undergoing radical esophagectomy...
  61. doi Errors in fluid therapy in medical wards
    Maryam Mousavi
    Tehran University of Medical Sciences, Tehran, Iran
    Int J Clin Pharm 34:374-81. 2012
    Intravenous fluid therapy remains an essential part of patients' care during hospitalization...
  62. doi Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a "gray zone" approach
    Maxime Cannesson
    Department of Anesthesiology and Perioperative Care, School of Medicine, University of California, Irvine, Irvine, California, USA
    Anesthesiology 115:231-41. 2011
    ..The authors sought to test the predictive value of PPV in a large, multicenter study and to express it using a gray zone approach...
  63. pmc A critique of fluid bolus resuscitation in severe sepsis
    Andrew K Hilton
    Department of Intensive Care, Alfred Hospital, and Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Crit Care 16:302. 2012
    ..In the present article, we contend that the concept of large fluid bolus resuscitation in sepsis needs to be investigated further...
  64. doi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    ..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
  65. doi The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen, Germany
    Intensive Care Med 36:1299-308. 2010
    ..This review presents the (patho)physiological basis of hypovolemia, microcirculation, and tissue oxygenation and presents a literature review on the effects of plasma substitutes on microperfusion and oxygenation in the clinical setting...
  66. ncbi Determinants of use rate of oral rehydration therapy for management of childhood diarrhoea in rural Bangladesh
    M Ali
    Department of General Practice, University of Western Australia, Fremantle Hospital, Australia
    J Health Popul Nutr 18:103-8. 2000
    ..Promotion of ORT can be effected by improving the level of understanding of mothers with regard to assessment of severity, early initiation of treatment regardless of age, sex, type of diarrhoea, breast-feeding, and nutrition status...
  67. pmc Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome
    Karim Lakhal
    Service de Réanimation Médicale et Maladies Infectieuses, Hopital Bichat Claude Bernard, Assistance Publique des Hopitaux de Paris, 18 rue Henri Huchard, F 75018 Paris, France
    Crit Care 15:R85. 2011
    ..We aimed to assess ΔRESPPP in a large ARDS population...
  68. ncbi The impact of opioid administration on resuscitation volumes in thermally injured patients
    Lucy Wibbenmeyer
    Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, UT 52246, USA
    J Burn Care Res 31:48-56. 2010
    ..Because increased fluid resuscitation has been associated with adverse consequences in other studies, further research on alternative pain control strategies in thermally injured patients is warranted...
  69. ncbi Predicting increased fluid requirements during the resuscitation of thermally injured patients
    Leopoldo C Cancio
    US Army Institute of Surgical Research, Charleston, South Carolina, USA
    J Trauma 56:404-13; discussion 413-4. 2004
    ....
  70. ncbi Colloid administration normalizes resuscitation ratio and ameliorates "fluid creep"
    Amanda Lawrence
    Burn Trauma ICU, Department of Surgery, University of Utah College of Medicine, Salt Lake City, Utah, USA
    J Burn Care Res 31:40-7. 2010
    ..This practice can be applied selectively as needed using predetermined algorithms...
  71. pmc Dynamic arterial elastance to predict arterial pressure response to volume loading in preload-dependent patients
    Manuel Ignacio Monge García
    Servicio de Cuidados Criticos y Urgencias, Unidad de Investigación Experimental, Hospital del SAS de Jerez, Jerez de la Frontera, Spain
    Crit Care 15:R15. 2011
    ....
  72. doi Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 37:650-8. 2009
    ..Therefore, the present study was designed to evaluate whether PPV and SVV are suitable for predicting fluid responsiveness during elevated IAP...
  73. ncbi Fluid therapy for the surgical patient
    Birgitte Brandstrup
    Surgical Department, Slagelse University Hospital, Ingemannsvej 18, DK 4200 Slagelse, Denmark
    Best Pract Res Clin Anaesthesiol 20:265-83. 2006
    Perioperative fluid therapy is the subject of much controversy, and the results of the clinical trials investigating the effect of fluid therapy on outcome of surgery seem contradictory...
  74. ncbi Arterial versus plethysmographic dynamic indices to test responsiveness for testing fluid administration in hypotensive patients: a clinical trial
    Giuseppe Natalini
    Department of Anesthesiology, Intensive Care Medicine and Emergency Medicine, Poliambulanza Foundation Hospital, Brescia, Italy
    Anesth Analg 103:1478-84. 2006
    ..These plethysmographic indices could provide a noninvasive tool for predicting the cardiac output increase by administering fluid...
  75. doi Conservative vs restrictive individualized goal-directed fluid replacement strategy in major abdominal surgery: A prospective randomized trial
    Emmanuel Futier
    Department of Anesthesiology and Critical Care, University Hospital of Clermont Ferrand, France
    Arch Surg 145:1193-200. 2010
    To compare the influence of 2 volumes of fluid, integrated with goal-directed fluid therapy, on hypovolemia (a key trigger of tissue hypoperfusion) and central venous oxygen saturation (Scvo₂) and to assess their relationships with ..
  76. doi The Parkland formula under fire: is the criticism justified?
    Jennifer Blumetti
    University of Texas Southwestern, Dallas, Texas, USA
    J Burn Care Res 29:180-6. 2008
    ..The Parkland formula only represents a resuscitation "starting" point. The UOP is the important parameter...
  77. doi The use of theraputic plasma exchange (TPE) in the setting of refractory burn shock
    Lucas P Neff
    Wake Forest University Baptist Medical Center, Department of General Surgery, Winston Salem, NC 27157, USA
    Burns 36:372-8. 2010
    ..This study examines the physiologic effects of theraputic plasma exchange (TPE) in the setting of refractory burn shock and attempts to identify variables that correlate with the eventual need for TPE...
  78. doi Preoperative fluid and electrolyte management with oral rehydration therapy
    Hideki Taniguchi
    Department of Anesthesiology, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    J Anesth 23:222-9. 2009
    ....
  79. doi Pulse pressure variations adjusted by alveolar driving pressure to assess fluid responsiveness
    Fabrice Vallee
    Pôle Anesthésie et Réanimation, unité de réanimation polyvalente de Purpan, GRCB 48, Universite Paul Sabatier, Toulouse, France
    Intensive Care Med 35:1004-10. 2009
    ....
  80. ncbi Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 97:820-6. 2002
    ..The objective of this prospective, randomized study was to assess the effect of goal-directed intraoperative fluid administration on length of postoperative hospital stay...
  81. ncbi Safety of rapid intravenous rehydration and comparative efficacy of 3 oral rehydration solutions in the treatment of severely malnourished children with dehydrating cholera
    Nur H Alam
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    J Pediatr Gastroenterol Nutr 48:318-27. 2009
    ..Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions...
  82. doi Physiological effects of hyperchloraemia and acidosis
    J M Handy
    Chelsea and Westminster NHS Foundation Trust, Imperial College London, 369 Fulham Road, London SW10 9NH, UK
    Br J Anaesth 101:141-50. 2008
    ..It is intended to provide an assessment of the importance of hyperchloraemic acidosis and thereby the likely benefits of balanced solutions...
  83. doi Preliminary results of a prospective randomized trial of restrictive versus standard fluid regime in elective open abdominal aortic aneurysm repair
    Geralde T McArdle
    Regional Vascular Surgery Unit, Royal Victoria Hospital Belfast, Belfast Health and Social Care Trust, Belfast BT14 6AB, Northern Ireland
    Ann Surg 250:28-34. 2009
    ..We tested the hypothesis that perioperative fluid restriction would reduce complications and improve outcome after elective open AAA repair...
  84. doi 'Liberal' vs. 'restrictive' perioperative fluid therapy--a critical assessment of the evidence
    M Bundgaard-Nielsen
    Section of Surgical Pathophysiology, University of Copenhagen, Copenhagen, Denmark
    Acta Anaesthesiol Scand 53:843-51. 2009
    ..Several studies have assessed the effect of a 'liberal' vs. a 'restrictive' perioperative fluid regimen on post-operative outcome. The literature was reviewed in order to provide recommendations regarding perioperative fluid regimens...
  85. doi Goal-directed fluid management based on the pulse oximeter-derived pleth variability index reduces lactate levels and improves fluid management
    Patrice Forget
    Department of Anesthesiology, St Luc Hospital, Brussels, Belgium
    Anesth Analg 111:910-4. 2010
    ..We investigated whether displaying the variability in the pulse oximeter plethysmogram (pleth variability index; PVI) would guide intraoperative fluid management and improve circulation as assessed by lactate levels...
  86. ncbi Fluid administration in critically ill patients with acute kidney injury
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Room 7001, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 5:733-9. 2010
    ....
  87. pmc Crystalloids versus colloids for goal-directed fluid therapy in major surgery
    Luzius B Hiltebrand
    Department of Anaesthesiology and Pain Therapy, Inselspital, Bern University Hospital, Freiburgstrasse, Bern, CH 3010, Switzerland
    Crit Care 13:R40. 2009
    ..Goal-directed fluid therapy might reduce these complications...
  88. ncbi Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality
    Richard P Dutton
    R Adams Cowley Shock Trauma Center and the Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Trauma 52:1141-6. 2002
    ..We hypothesized that fluid resuscitation titrated to a lower than normal SBP during the period of active hemorrhage would improve survival in trauma patients presenting to the hospital in hemorrhagic shock...
  89. pmc Treatment patterns for childhood diarrhoea: evidence from demographic and health surveys
    P K Muhuri
    Epidemiological Surveillance Service, Division of Health Situation and Trend Assessment, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 74:135-46. 1996
    ..The results indicate that national public health programmes must continue to improve their strategies to ensure correct treatment of childhood diarrhoea by all health providers...
  90. ncbi Effect of Saccharomyces boulardii in the treatment of acute watery diarrhea in Myanmar children: a randomized controlled study
    Khin Htwe
    Department of Child Health, North Okkalapa General Hospital, University of Medicine, Yangon, Myanmar
    Am J Trop Med Hyg 78:214-6. 2008
    ..019). Saccharomyces boulardii shortens the duration of diarrhea and normalizes stool consistency and frequency. The shortening of the duration of diarrhea results in a social and economic benefits...
  91. ncbi Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection
    S E Noblett
    Department of Surgery, Freeman Hospital, and Department of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, UK
    Br J Surg 93:1069-76. 2006
    ..Protocolized fluid administration using oesophageal Doppler monitoring may improve the postoperative outcome in patients undergoing surgery...
  92. ncbi Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge
    David Osman
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
    Crit Care Med 35:64-8. 2007
    ..By analyzing a large number of volume challenges, our aim was to test the significance of the recommended target values in terms of prediction of volume responsiveness...
  93. pmc Relation between respiratory variations in pulse oximetry plethysmographic waveform amplitude and arterial pulse pressure in ventilated patients
    Maxime Cannesson
    Service de Reanimation Medicale, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Crit Care 9:R562-8. 2005
    ..We conducted a prospective study to evaluate the relationship between respiratory variation in arterial pulse pressure and respiratory variation in pulse oximetry plethysmographic (POP) waveform amplitude...
  94. ncbi Volumetric preload measurement by thermodilution: a comparison with transoesophageal echocardiography
    C K Hofer
    Institute of Anaesthesiology and Intensive Care Medicine, Triemli City Hospital, Zurich, Switzerland
    Br J Anaesth 94:748-55. 2005
    ..The aim of this study was to compare volume preload monitoring using the two different thermodilution techniques with left ventricular preload assessment by transoesophageal echocardiography (TOE)...
  95. ncbi Plethysmographic dynamic indices predict fluid responsiveness in septic ventilated patients
    Marc Feissel
    Medical Intensive Care Unit, Centre Hospitalier, Belfort, France
    Intensive Care Med 33:993-9. 2007
    ....
  96. ncbi Pulse pressure variations to predict fluid responsiveness: influence of tidal volume
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital of the Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 31:517-23. 2005
    ..To evaluate the influence of tidal volume on the capacity of pulse pressure variation (DeltaPP) to predict fluid responsiveness...
  97. ncbi Liberal or restrictive fluid administration in fast-track colonic surgery: a randomized, double-blind study
    K Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Br J Anaesth 99:500-8. 2007
    ..Therefore, we investigated the effects of two regimens of intraoperative fluids with physiological recovery as the primary outcome measure after fast-track colonic surgery...
  98. ncbi Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury
    Arthur P Wheeler
    Vanderbilt University, Nashville, USA
    N Engl J Med 354:2213-24. 2006
    ..The balance between the benefits and the risks of pulmonary-artery catheters (PACs) has not been established...
  99. ncbi Postoperative complications in gastrointestinal cancer patients: the joint role of the nutritional status and the nutritional support
    Federico Bozzetti
    Department of Surgery, Hospital of Prato, Piazza dell Ospedale 5, 59100 Prato, Italy
    Clin Nutr 26:698-709. 2007
    ..This study investigated the effects of nutritional support on postoperative complications, in relation with demographic and nutritional factors, intraoperative factors, type and routes of nutritional regimens...
  100. ncbi Acute traumatic coagulopathy
    Karim Brohi
    Trauma and Critical Care Unit, Royal London Hospital, United Kingdom
    J Trauma 54:1127-30. 2003
    ..Traumatic coagulopathy is thought to be caused primarily by fluid administration and hypothermia...
  101. ncbi Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients
    Marc Maegele
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimerstr 200, D 51109 Cologne, Germany
    Injury 38:298-304. 2007
    ..There is increasing evidence for acute traumatic coagulopathy occurring prior to emergency room (ER) admission but detailed information is lacking...

Research Grants111 found, 100 shown here

  1. Decision-Assist and Closed-Loop Fluid Resuscitation of Burn-Injured Patients
    George Kramer; Fiscal Year: 2009
    ..This project will develop software and associated hardware systems to guide and perform fluid therapy in critically injured patients...
  2. Lactobacilli surface antibody expression for in vivo protection against cholera
    Paul Wentworth; Fiscal Year: 2010
    ..We will develop a human antibody to cholera toxin and express it on Lactobacilli and colonize the gut with this biotechnology tool. It will be an invaluable tool for the traveler and first responders and armed forces personnel. ..
  3. Assessment of Dehydration in Children with Diarrhea in Resource-Limited Settings
    ADAM CARL LEVINE; Fiscal Year: 2012
    ....
  4. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    Ernest M Wright; Fiscal Year: 2010
    ..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
  5. Probiotics for Infectious Diarrhea in Children in South India
    Honorine Ward; Fiscal Year: 2009
    ..These studies are important to help understand whether and how probiotics work in protecting and healing the intestine. ..
  6. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2009
    ..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
  7. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2009
    ..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
  8. Probiotics in Pediatric Diarrhea in Peru
    Richard Oberhelman; Fiscal Year: 2009
    ....
  9. Probiotics in Pediatric Diarrhea in Peru
    Richard A Oberhelman; Fiscal Year: 2010
    ....
  10. Probiotics in Pediatric Diarrhea in Peru
    Richard Oberhelman; Fiscal Year: 2007
    ....
  11. INTRAVENOUS FLUID THERAPY AND HEAD INJURY
    Steven Shackford; Fiscal Year: 1990
    ..Intravenous fluid therapy is necessary in all of these patients, especially those who require resuscitation from hypovolemic shock...
  12. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2002
    ..abstract_text> ..
  13. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2003
    ..abstract_text> ..
  14. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2000
    ..abstract_text> ..
  15. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 1999
    ..abstract_text> ..
  16. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2001
    ..abstract_text> ..
  17. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2004
    ..abstract_text> ..
  18. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2005
    ..abstract_text> ..
  19. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2002
    ..abstract_text> ..
  20. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2006
    ..abstract_text> ..
  21. Probiotics in Pediatric Diarrhea in Peru_Supplement
    Richard A Oberhelman; Fiscal Year: 2012
    ....
  22. Microvascular Barrier Dysfunction in Thermal Injury
    Sarah Yuan; Fiscal Year: 2009
    ..Intensive fluid therapy is necessary for maintaining circulatory stability during the initial resuscitation period;however, without ..
  23. Microvascular Barrier Dysfunction in Thermal Injury
    Sarah Y Yuan; Fiscal Year: 2010
    ..Intensive fluid therapy is necessary for maintaining circulatory stability during the initial resuscitation period;however, without ..
  24. PROBIOTICS IN PEDIATRIC DIARRHEA IN PERU: PLANNING GRANT
    Richard Oberhelman; Fiscal Year: 2005
    ..Support for these activities during a planning period before the clinical trial will greatly facilitate the implementation of the trial. ..
  25. PROBIOTICS IN PEDIATRIC DIARRHEA IN PERU: PLANNING GRANT
    Richard Oberhelman; Fiscal Year: 2006
    ..Support for these activities during a planning period before the clinical trial will greatly facilitate the implementation of the trial. ..
  26. RESISTANT STARCH: ADJUNCT TO ORAL REHYDRATION SOLUTION
    HENRY BINDER; Fiscal Year: 2000
    ..Treatment failures will be categorized and recorded. If resistant starch is found to reduce fecal volumes and/or duration of diarrhea, this innovative therapy must then be tested in the community for acceptance. ..
  27. RESISTANT STARCH--ADJUNCT TO ORAL REHYDRATION SOLUTION
    HENRY BINDER; Fiscal Year: 1999
    ..Treatment failures will be categorized and recorded. If resistant starch is found to reduce fecal volumes and/or duration of diarrhea, this innovative therapy must then be tested in the community for acceptance. ..
  28. Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis
    NATHAN contact KUPPERMANN; Fiscal Year: 2010
    ..The relationship of fluid therapy for DKA and risk of cerebral injury and cerebral edema is not well understood and has been debated for decades...
  29. Cellular Molecular Mechanisms of Alanyl-Glutamine Oral Rehydration and Nutrition
    SEAN RYAN MOORE; Fiscal Year: 2011
    ....
  30. Decision-Assist and Closed-Loop Fluid Resuscitation of Burn-Injured Patients
    George C Kramer; Fiscal Year: 2010
    ..This project will develop software and associated hardware systems to guide and perform fluid therapy in critically injured patients...
  31. MECHANISMS OF INTESTINAL CELL MIGRATION
    JON RHOADS; Fiscal Year: 2001
    ..Active growth peptides in serum will be identified and quantified. We will determine if ARG potentiates serum growth factor signaling or activates separate signaling pathways during migration. ..
  32. MECHANISMS OF INTESTINAL CELL MIGRATION
    JON RHOADS; Fiscal Year: 2000
    ..Active growth peptides in serum will be identified and quantified. We will determine if ARG potentiates serum growth factor signaling or activates separate signaling pathways during migration. ..
  33. Vibrio Cholerae as a bioterror agent: New means of treating a potential pandemic
    Anjaparavanda Naren; Fiscal Year: 2007
    ..cholerae or due to natural causes. [unreadable] [unreadable] [unreadable]..
  34. Alanyl-glutamine as Oral Rehydration & Nutrition Therapy
    GERLY BRITO; Fiscal Year: 2001
    ..proposed commercial application: not available ..
  35. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2003
    ..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
  36. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2007
    ..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
  37. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2005
    ..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
  38. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2006
    ..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
  39. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    ERNEST WRIGHT; Fiscal Year: 2004
    ..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
  40. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2005
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  41. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2003
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  42. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2002
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  43. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2004
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  44. INTESTINAL EPITHELIAL FUNCTION AND REPAIR IN HIV RELATED DIARRHEA
    Nathan Thielman; Fiscal Year: 1999
    ..abstract_text> ..
  45. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2006
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  46. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  47. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2007
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  48. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2008
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  49. CLINICAL RESEARCH ENHANCEMENT FROM SUPPLEMENTAL TRAINING
    Ravindra Mehta; Fiscal Year: 2008
    ..IOur goal is to ensure that scholars emerging from this program will have the fundamental skills Inecessary for independent clinical research. ..
  50. CLINICAL RESEARCH ENHANCEMENT FROM SUPPLEMENTAL TRAINING
    Ravindra Mehta; Fiscal Year: 2007
    ..IOur goal is to ensure that scholars emerging from this program will have the fundamental skills Inecessary for independent clinical research. ..
  51. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  52. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 1999
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  53. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2000
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  54. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2006
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  55. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2009
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  56. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2007
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  57. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  58. Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS
    John A Kellum; Fiscal Year: 2010
    ....
  59. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  60. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2005
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  61. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2008
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  62. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  63. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2008
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  64. NEURAL REGULATION OF VASOPRESSIN RELEASE
    J Cunningham; Fiscal Year: 2000
    ..Therefore, understanding the neural pathways involved in the arterial baroreceptor and atrial receptor regulation of vasopressin release is a necessary first step that is needed to address the role of vasopressin in health and disease. ..
  65. NEURAL REGULATION OF VASOPRESSIN RELEASE
    J Cunningham; Fiscal Year: 2009
    ..Benefits: The results will provide new information regarding the control of vasopressin secretion and how these systems contribute to pathophysiology. ..
  66. INTESTINAL ELECTROLYTE TRANSPORT IN HEALTH & DISEASE
    HENRY BINDER; Fiscal Year: 1991
    ....
  67. Integrating Interventions to Improve Fecal Incontinence
    John Schnelle; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  68. CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
    J Cunningham; Fiscal Year: 2004
    ..Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure. ..
  69. Novel treatments for polycystic kidney disease
    Vicente Torres; Fiscal Year: 2009
    ..abstract_text> ..
  70. REDOX, ACID/BASE, AND PATHOGENESIS OF ADPKD
    Vicente Torres; Fiscal Year: 1999
    ..The main thrust of the proposed studies is directed towards the identification of pathogenetic mechanisms than can be subject to preventive and therapeutic interventions. ..
  71. INTESTINAL ELECTROLYTE TRANSPORT IN HEALTH AND DISEASE
    HENRY BINDER; Fiscal Year: 1990
    ....
  72. Acute Renal Failure Mediated Lung Injury
    Sarah Faubel; Fiscal Year: 2009
    ....
  73. Immunological Basis of Egg Allergy
    Anna Nowak Wegrzyn; Fiscal Year: 2008
    ..Intestinal permeability will also be measured at 3 and 12 months, and correlated with oral egg challenge outcome, fecal and serum anti-egg IgE and anti-egg IgG antibody levels. ..
  74. Colonic Crypt HCO3 Secretion
    HENRY BINDER; Fiscal Year: 2005
    ..e., cNBC) differs substantially from other NBCs and may represent a novel epithelial cell NBC. We propose comprehensive transport, electrophysiological and molecular studies to characterize crypt HCO3 secretion. ..
  75. Colonic Crypt HCO3 Secretion
    HENRY BINDER; Fiscal Year: 2004
    ..e., cNBC) differs substantially from other NBCs and may represent a novel epithelial cell NBC. We propose comprehensive transport, electrophysiological and molecular studies to characterize crypt HCO3 secretion. ..
  76. KIDNEY DISEASE RESEARCH TRAINING PROGRAM
    Vicente Torres; Fiscal Year: 2007
    ..abstract_text> ..
  77. Supplemental Fluid & Collagen Deposition
    Nancy Stotts; Fiscal Year: 2005
    ..Significance: Findings from the study have the potential to significantly change how fluid is managed in nursing home residents and to lay the foundation for a major intervention study on pressure ulcer healing. ..
  78. Immunological Basis of Egg Allergy
    Anna Nowak Wegrzyn; Fiscal Year: 2007
    ..Intestinal permeability will also be measured at 3 and 12 months, and correlated with oral egg challenge outcome, fecal and serum anti-egg IgE and anti-egg IgG antibody levels. ..
  79. RENIN ANGIOTENSIN SYSTEM IN THE PATHOGENESIS OF ADPKD
    Vicente Torres; Fiscal Year: 1992
    ..The results of these studies will augment the understanding of the pathogenesis of cyst formation and hypertension in ADPKD and are likely to have a significant impact on the treatment of this disease...
  80. REDOX, ACID/BASE, AND PATHOGENESIS OF ADPKD
    Vicente Torres; Fiscal Year: 2001
    ..The main thrust of the proposed studies is directed towards the identification of pathogenetic mechanisms than can be subject to preventive and therapeutic interventions. ..