physical restraint

Summary

Summary: Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.

Top Publications

  1. ncbi Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice
    Kazufumi Nagata
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara ku, Kawasaki, Japan
    Neuropsychopharmacology 34:501-8. 2009
  2. ncbi Chronic stress alters dendritic morphology in rat medial prefrontal cortex
    Susan C Cook
    Department of Psychology, Indiana University, Bloomington, Indiana 47405, USA
    J Neurobiol 60:236-48. 2004
  3. ncbi Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study
    H S Donohue
    Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
    Neuroscience 140:597-606. 2006
  4. ncbi Constraint-induced movement therapy during early stroke rehabilitation
    Corwin Boake
    Department of Physical Medicine, Baylor College of Medicine University of Texas Houston Medical School, Houston, TX, USA
    Neurorehabil Neural Repair 21:14-24. 2007
  5. pmc Use of physical restraint in nursing homes: clinical-ethical considerations
    C Gastmans
    Center for Biomedical Ethics and Law, Catholic University of Leuven, Kapucijnenvoer 35, B 3000 Leuven, Belgium
    J Med Ethics 32:148-52. 2006
  6. ncbi Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
  7. ncbi Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms
    J L Madrigal
    , Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Neurochem 76:532-8. 2001
  8. ncbi Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuropharmacology 54:108-16. 2008
  9. ncbi Effects of chronic stress on hippocampal long-term potentiation
    Constantine Pavlides
    The Rockefeller University, New York, New York 10021, USA
    Hippocampus 12:245-57. 2002
  10. ncbi Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
    N Sousa
    Department of Anatomy, Porto Medical School, Alameda Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Neuroscience 97:253-66. 2000

Research Grants

  1. Physical Restraints and Therapy Disruption in Hospitals
    Ann Minnick; Fiscal Year: 2005
  2. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    Paul E Sawchenko; Fiscal Year: 2012
  3. Interaction Behaviors Effect on Nursing Care Quality of Older Adults in the ICU
    Marci Lee Nilsen; Fiscal Year: 2012
  4. Patient Care Outcomes at End-of-Life for Older Adults in ICU
    Jennifer B Seaman; Fiscal Year: 2013
  5. CMS Nonpayment for Nosocomial Injury and Risk of Falls in Hospitals
    Ronald I Shorr; Fiscal Year: 2010
  6. CONSEQUENCES OF PHYSICAL RESTRAINTS
    Nicholas Castle; Fiscal Year: 2004
  7. USE OF PHYSICAL RESTRAINTS FOR ELDERLY PATIENTS
    Lorraine Mion; Fiscal Year: 1991
  8. DOT and fMRI Studies of Visual Perception and Imagery
    Giorgio Ganis; Fiscal Year: 2005
  9. Improving Communication with NonSpeaking ICU Patients
    MARY HAPP; Fiscal Year: 2007
  10. NEURODEVELOPMENTAL INSULTS AND SCHIZOPHRENIA
    RUSSELL POLAND; Fiscal Year: 2001

Detail Information

Publications210 found, 100 shown here

  1. ncbi Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice
    Kazufumi Nagata
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara ku, Kawasaki, Japan
    Neuropsychopharmacology 34:501-8. 2009
    ..Chronic physical restraint stress to mice enhanced levels of oxidative stress markers, malondialdehyde and 4-hydroxy-2-nonenal, in the ..
  2. ncbi Chronic stress alters dendritic morphology in rat medial prefrontal cortex
    Susan C Cook
    Department of Psychology, Indiana University, Bloomington, Indiana 47405, USA
    J Neurobiol 60:236-48. 2004
    ..This reorganization likely reflects functional changes in prefrontal cortex and may contribute to stress-induced changes in cognition...
  3. ncbi Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study
    H S Donohue
    Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
    Neuroscience 140:597-606. 2006
    ..The data indicate a structural remodeling of excitatory axo-spinous synaptic connectivity in rat CA1 stratum lacunosum-moleculare as a result of chronic restraint stress...
  4. ncbi Constraint-induced movement therapy during early stroke rehabilitation
    Corwin Boake
    Department of Physical Medicine, Baylor College of Medicine University of Texas Houston Medical School, Houston, TX, USA
    Neurorehabil Neural Repair 21:14-24. 2007
    ..Limited data are available about the effectiveness of early rehabilitation after stroke...
  5. pmc Use of physical restraint in nursing homes: clinical-ethical considerations
    C Gastmans
    Center for Biomedical Ethics and Law, Catholic University of Leuven, Kapucijnenvoer 35, B 3000 Leuven, Belgium
    J Med Ethics 32:148-52. 2006
    This article gives a brief overview of the state of the art concerning physical restraint use among older persons in nursing homes...
  6. ncbi Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
    ..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...
  7. ncbi Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms
    J L Madrigal
    , Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Neurochem 76:532-8. 2001
    ....
  8. ncbi Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuropharmacology 54:108-16. 2008
    ..These studies are consistent with the hypothesis that stress exposure alters endocannabinoid signaling in the brain and that alterations in endocannabinoid signaling occur during habituation to stress...
  9. ncbi Effects of chronic stress on hippocampal long-term potentiation
    Constantine Pavlides
    The Rockefeller University, New York, New York 10021, USA
    Hippocampus 12:245-57. 2002
    ..Furthermore, they suggest that chronic stress produces changes in the input-output relationship in the hippocampal trisynaptic circuit which could affect information flow through this structure...
  10. ncbi Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
    N Sousa
    Department of Anatomy, Porto Medical School, Alameda Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Neuroscience 97:253-66. 2000
    ..We conclude that there is an intimate relationship between corticosteroid levels, hippocampal neuritic structure and hippocampal-dependent learning and memory...
  11. ncbi Physical restraint use in a Korean ICU
    Eunha Choi
    Seoul National University Hospital, Seoul, Korea
    J Clin Nurs 12:651-9. 2003
    ....
  12. ncbi 'It's part of the job, but it spoils the job': a phenomenological study of physical restraint
    Stuart Bigwood
    Mental Health Services, Canterbury District Health Board, Christchurch, New Zealand
    Int J Ment Health Nurs 17:215-22. 2008
    This paper examines mental health nurses' experiences of physical restraint in an acute inpatient psychiatric setting using Van Manen's descriptive hermeneutic phenomenological methodology...
  13. ncbi Influence of physical restraint on unplanned extubation of adult intensive care patients: a case-control study
    Li Yin Chang
    Taichung Veterans General Hospital, Taichung, Taiwan
    Am J Crit Care 17:408-15; quiz 416. 2008
    ..Various physical restraints have been used to prevent patients from removing their endotracheal tubes. However, physical restraint not only does not consistently prevent injury but also may be a safety hazard to patients.
  14. ncbi An audit of physical restraint and seclusion in five psychogeriatric admission wards in Victoria, Australia
    Daniel O'Connor
    Int J Geriatr Psychiatry 19:797-9. 2004
  15. ncbi Psychiatric inpatients' perceptions of positive and negative aspects of physical restraint
    Wai Tong Chien
    The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, CUHK, Shatin, NT, SAR, China
    Patient Educ Couns 59:80-6. 2005
    ..study explored the experiences and feelings of psychiatric inpatients concerning their first encounter with physical restraint. Its purpose was to determine whether restraint has any other effects, other than the intended one of ..
  16. ncbi The conceptualization of physical restraint as a nursing-sensitive adverse outcome in acute care psychiatric treatment settings
    Angela M Gerolamo
    Center for Health Outcomes and Policy Research, University of Pennsylvania, Philadelphia, PA
    Arch Psychiatr Nurs 20:175-85. 2006
    The occurrence of physical restraint episodes in psychiatric settings is a major public health issue because the therapeutic utility of this form of behavior control has not been substantiated empirically...
  17. ncbi Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 16:313-20. 2006
    ..Dendritic atrophy and spine loss may be important cellular features of stress-related psychiatric disorders where the PFC is functionally impaired...
  18. ncbi Responding to a violent incident: physical restraint or anger management as therapeutic interventions
    D M Lewis
    Queen Anne s Gate, London, UK
    J Psychiatr Ment Health Nurs 9:57-63. 2002
    ..The importance of this paper lies in reorienting forensic clinicians away from the perceived ideologies of physical restraint as a primary intervention, moving towards the productive use of anger management.
  19. ncbi Deep venous thrombosis and pulmonary embolism following physical restraint
    S B Laursen
    University Clinic of Neuroanaesthesia, The Neuroscience Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Acta Psychiatr Scand 111:324-7; discussion 327. 2005
    We describe a case of deep venous thrombosis (DVT) and pulmonary embolism (PE) following the use of physical restraint in a patient with a diagnosis of acute delusional psychotic disorder.
  20. ncbi A program to reduce use of physical restraint in psychiatric inpatient facilities
    Jessica A Jonikas
    Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL 60603, USA
    Psychiatr Serv 55:818-20. 2004
    The authors describe a program to reduce the use of physical restraint on three psychiatric units of a university hospital...
  21. ncbi A review of physical restraint minimization in the acute and residential care settings
    David Evans
    Department of Clinical Nursing, University of Adelaide, Adelaide, South Australia, Australia
    J Adv Nurs 40:616-25. 2002
    The objective of this review was to investigate physical restraint minimization in acute and residential care settings...
  22. pmc The effects of chronic stress on hippocampal morphology and function: an evaluation of chronic restraint paradigms
    Katie J McLaughlin
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Brain Res 1161:56-64. 2007
    ....
  23. pmc Chronic stress alters synaptic terminal structure in hippocampus
    A M Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:14002-8. 1997
    ....
  24. ncbi Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex
    Sarah M Brown
    Department of Psychology, Indiana University, Bloomington, IN 47405, USA
    Cereb Cortex 15:1714-22. 2005
    ..Thus, the stress-induced dendritic changes in medial prefrontal cortex occur rapidly, and in response to a mild stressor...
  25. ncbi Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups
    C V Dayas
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia 4072
    Eur J Neurosci 14:1143-52. 2001
    ..Moreover, the present data suggest that the neural activation footprint that is left in the brain by stressors can be used to determine the category to which they have been assigned by the brain...
  26. ncbi Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  27. ncbi Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity
    Richard J Windle
    University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    J Neurosci 24:2974-82. 2004
    ..These data show that central oxytocin attenuates both the stress-induced neuroendocrine and molecular responses of the HPA axis and that the dorsal hippocampus, LSV, and PVN constitute an oxytocin-sensitive forebrain stress circuit...
  28. ncbi Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposure
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Psychoneuroendocrinology 31:526-36. 2006
    ..This interaction was not seen in the basolateral amygdala. Together, these findings suggest that chronic high dose, but not low dose, cannabinoid administration may result in increased emotionality and sensitization of the stress axis...
  29. ncbi Reproducibility of patient positioning for fractionated extracranial stereotactic radiotherapy using a double-vacuum technique
    Meinhard Nevinny-Stickel
    Department of Radiotherapy Radiooncology, University Hospital Innsbruck, Austria
    Strahlenther Onkol 180:117-22. 2004
    ..A fixation system based on double-vacuum technology is presented which can be used for conventional as well as hypofractionated stereotactic extracranial radiotherapy...
  30. ncbi The use of physical restraint in critical care
    Karen Hine
    Intensive Care Unit, County Hospital, Lincoln, UK
    Nurs Crit Care 12:6-11. 2007
    ..The use of physical restraint appears to be a useful and simple solution to prevent this treatment interference...
  31. ncbi Re-designing state mental health policy to prevent the use of seclusion and restraint
    Kevin Ann Huckshorn
    National Technical Assistance Center, National Association of State Mental Health Program Directors NAMSHPD, Alexandria, VA 22314, USA
    Adm Policy Ment Health 33:482-91. 2006
    ..Endorsed by the State Mental Health Directors, July 13, 1999). (NASMHPD 1999, NASMHPD Position Statement on Seclusion and Restraint. Alexandria, VA: National Technical Assistance Center for State Mental Health Planning.)...
  32. ncbi A review of agitation in mental illness: treatment guidelines and current therapies
    Stephen R Marder
    Department of Psychiatry, David Geffen School of Medicine at the University of California Los Angeles, VISN 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, Calif, USA
    J Clin Psychiatry 67:13-21. 2006
    ..Agitation is an important therapeutic target in the acute and/or emergent setting, as well as for longer-term care of patients with psychiatric illness...
  33. ncbi The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0559, USA
    Eur J Neurosci 18:2357-64. 2003
    ..Taken together, this study indicates that the medial prefrontal cortex differentially regulates cellular activation of specific stress-related brain regions, thus exerting stressor-dependent inhibition of the HPA axis...
  34. pmc Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York, NY 10021, USA
    Brain Res 1152:234-40. 2007
    ..Our data establish that CART expression is regulated by stress in a regionally and time specific manner and that CART is regulated by corticosteroid actions in the hippocampus...
  35. ncbi Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress
    R L Torres
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 90035 003 Porto Alegre, RS, Brasil
    Braz J Med Biol Res 37:185-92. 2004
    ..48 +/- 0.42; stressed: 3.65 +/- 0.16, P < 0.05). We conclude that different stressors induce different effects on the oxidative status of the organism...
  36. ncbi The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction
    Angel Ponferrada
    Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Maranon, Madrid
    Gastroenterology 132:1791-803. 2007
    ..Psychological stress has been implicated in the clinical course of several gastrointestinal diseases, but the mechanisms implicated and the effects of stress on the normal colon are not yet fully understood...
  37. pmc Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats
    Helene Eutamene
    Institut National de la Recherche Agronomique, Department of Neurogastroenterology and Nutrition, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse, France
    J Physiol 553:959-66. 2003
    ..C.V. CRF administration. These results suggest that in rats acute stress increases colonic mast cell histamine content. This effect is mediated by the release in cascade in the brain first of IL-1 and secondly of CRF...
  38. ncbi L-NAME prevents anxiety-like and depression-like behavior in rats exposed to restraint stress
    S Sevgi
    Department of Pharmacology and Clinical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Capa Istanbul, Turkey
    Methods Find Exp Clin Pharmacol 28:95-9. 2006
    ..These data lead to the conclusion that stress and NO seem to be involved in the generation of anxiety and depression...
  39. ncbi Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress
    S Ma
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Neuroendocrinol 17:22-8. 2005
    ....
  40. ncbi Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox
    A M Magarinos
    Department of Biology, Arizona State University, Tempe, USA
    Brain Res 809:314-8. 1998
    ....
  41. ncbi Development and testing of tools to assess physical restraint use
    Nancy Edwards
    School of Nursing, Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
    Worldviews Evid Based Nurs 3:73-85. 2006
    ..There is a need for a reliable and valid instrument that is feasible for use in these settings to rapidly assess physical restraint use.
  42. ncbi Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuropsychopharmacology 30:497-507. 2005
    ....
  43. ncbi Antioxidant potential of vitamins A, E and C in modulating oxidative stress in rat brain
    S M Kashif R Zaidi
    Department of Biochemistry, Faculty of Life Sciences, A M U 202002, Aligarh, India
    Clin Chim Acta 340:229-33. 2004
    ..The efficacy of antioxidant vitamins A, E and C alone and in combination was also evaluated in modulating inherent antioxidant system in stressed rats...
  44. ncbi Use of physical restraints with cognitively impaired nursing home residents
    Jan P H Hamers
    Associate Professor, Department of Health Care Studies, Section of Nursing Science, Universiteit Maastricht, Maastricht, The Netherlands
    J Adv Nurs 45:246-51. 2004
    The aim of the study was to examine the prevalence of physical restraint use in cognitively impaired nursing home residents, the manner in which restraints are used, reasons for using them, and relationships between residents' ..
  45. ncbi The mentally ill and social exclusion: a critical examination of the use of seclusion from the patient's perspective
    Dave Holmes
    University of Ottawa, Faculty of Health Sciences, School of Nursing Ottawa, Ontario, Canada
    Issues Ment Health Nurs 25:559-78. 2004
    ..A need for modifying the institutional culture surrounding seclusion and transforming nursing practices are discussed as are future research endeavours...
  46. ncbi The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats
    Borja García-Bueno
    Department of Pharmacology, Faculty of Medicine, Universidad Complutense Madrid, 28040, Madrid, Spain
    Psychopharmacology (Berl) 180:513-22. 2005
    ....
  47. ncbi Immediate active mobilization versus immobilization for opposition tendon transfer in the hand
    Santosh Rath
    LEPRA HOINA Leprosy Reconstructive Surgery Unit, Muniguda, Orissa, India
    J Hand Surg Am 31:754-9. 2006
    ..To test the hypothesis that immediate postoperative active mobilization of the hand after opposition tendon transfer will achieve outcomes similar to those of the standard practice of cast immobilization...
  48. ncbi SAMHSA's commitment to eliminating the use of seclusion and restraint
    Charles G Curie
    Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, Maryland 20857, USA
    Psychiatr Serv 56:1139-40. 2005
  49. ncbi Description of an advanced practice nursing consultative model to reduce restrictive siderail use in nursing homes
    Laura M Wagner
    Baycrest Centre for Geriatric Care, Kunin Lunenfeld Applied Research Unit, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Res Nurs Health 30:131-40. 2007
    ..Findings suggest that an APN consultation model can effectively be implemented through comprehensive, individualized assessment without incurring substantial costs to the nursing home...
  50. ncbi Minimizing the use of restrictive devices in dementia patients at risk for falling
    Elizabeth Capezuti
    John A Hartford Foundation Institute for Geriatric Nursing, Division of Nursing, Steinhardt School of Education, New York University, 246 Greene Street, 6th Floor, New York, NY 10003 6677, USA
    Nurs Clin North Am 39:625-47. 2004
    ..New institutional models of care discouraging routine use of restrictive devices also will foster innovative solutions to clinical problems associated with dementia...
  51. ncbi Pharmacological and biochemical studies on the possible role of nitric oxide in stress adaptation in rats
    Anbrin Masood
    Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India
    Eur J Pharmacol 493:111-5. 2004
    ..The results are suggestive of the role of nitric oxide in stress adaptation and this may be due to the effects of restraint stress on brain NOS activity...
  52. ncbi A systematic review of the safety and effectiveness of restraint and seclusion as interventions for the short-term management of violence in adult psychiatric inpatient settings and emergency departments
    Louise Nelstrop
    Royal College of Nursing Institute, Radcliffe Infirmary, Oxford, UK
    Worldviews Evid Based Nurs 3:8-18. 2006
    ..The review was undertaken as part of the development process for a national guideline on the short-term management of disturbed/violent behaviour in adult psychiatric inpatient settings and emergency departments in the United Kingdom...
  53. pmc Short-term effects of an educational intervention on physical restraint use: a cluster randomized trial
    Anna R Huizing
    Department of Health Care Studies, Section of Nursing Science, Maastricht University, Maastricht, The Netherlands
    BMC Geriatr 6:17. 2006
    ..The aim of this study was to investigate the short-term effects of an educational intervention on the use of physical restraints in psycho-geriatric nursing home residents...
  54. ncbi Differences in period prevalence of the use of physical restraints in elderly inpatients of European hospitals and nursing homes
    Oscar J de Vries
    J Gerontol A Biol Sci Med Sci 59:M922-3. 2004
  55. ncbi [Effectiveness of a multifactorial intervention to reduce physical restraints in nursing home residents with dementia]
    P Koczy
    Klinik für Geriatrische Rehabilitation, Robert Bosch Krankenhaus Stuttgart, Akademisches Lehrkrankenhaus der Universität Tübingen, Auerbachstrasse 110, 70376 Stuttgart, Germany
    Z Gerontol Geriatr 38:33-9. 2005
    ..The aim of the study is to develop an evidence-based model for a knowledge transfer project to implement minimum restraint environments in LTC...
  56. ncbi Why do we use physical restraints in the elderly?
    J P H Hamers
    Universiteit Maastricht, Department of Health Care Studies, Section of Nursing Science, 6200 MD Maastricht, The Netherlands
    Z Gerontol Geriatr 38:19-25. 2005
    ....
  57. ncbi The effect of staff training on the use of restraint in dementia: a single-blind randomised controlled trial
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger Norway
    Int J Geriatr Psychiatry 20:587-90. 2005
    ..Use of restraint amongst institutionalised elderly with dementia and problem behaviour not only remains widespread, but also appears to be accepted as inevitable...
  58. pmc Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates
    Kathleen M Friel
    Department of Molecular and Integrative Physiology, Landon Center on Aging, and Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS, USA
    Neurorehabil Neural Repair 21:51-61. 2007
    ..The goal of the present study was to determine if rehabilitative training has similar effects on functional topography of the spared M1 after rostral versus previously reported caudal M1 lesions...
  59. ncbi Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Eur J Neurosci 21:1057-69. 2005
    ....
  60. ncbi Overexpression of agouti protein and stress responsiveness in mice
    R B Harris
    Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA
    Physiol Behav 73:599-608. 2001
    ..Thus, the increased stress responsiveness in BAPa mice may be a developmental compensation for chronic inhibition of melanocortin receptors...
  61. ncbi Body weight gain and diurnal differences of corticosterone changes in response to acute and chronic stress in rats
    S Retana-Marquez
    Department of Reproductive Biology, Universidad Autonoma Metropolitana Iztapalapa, Mexico City, Mexico
    Psychoneuroendocrinology 28:207-27. 2003
    ....
  62. pmc Chronic stress and sex differences on the recall of fear conditioning and extinction
    Sarah E Baran
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, United States
    Neurobiol Learn Mem 91:323-32. 2009
    ....
  63. ncbi Perceptions regarding the use of physical restraints with elderly persons: comparison of Israeli health care nurses and social workers
    Perla Werner
    Department of Gerontology, Faculty of Social Welfare and Health Studies, University of Haifa, Mt Carmel, Haifa 31905, Israel
    J Interprof Care 16:59-68. 2002
    ....
  64. ncbi Feasibility of randomized controlled trials on seclusion and mechanical restraint
    Jan Bergk
    Department of Psychiatry I, University of Ulm, Weingartshofe str 2, 88214 Ravensburg, Germany
    Clin Trials 5:356-63. 2008
    ..The least restrictive alternative is recommended. Evidence about what kind of intervention is least restrictive is only scarcely available. Up to now, no randomized controlled trial (RCT) on this subject has been conducted...
  65. ncbi Coercive procedures and facilities in Swiss psychiatry
    Ian Needham
    Kantonale Psychiatric Hospital, CH 9500 Wil, Switzerland
    Swiss Med Wkly 132:253-8. 2002
    ..Coercive measures in psychiatry,although in many cases effective in violence management and injury reduction, have been criticised from a consumerist point of view...
  66. ncbi Attitudes of Dutch, German and Swiss nursing staff towards physical restraint use in nursing home residents, a cross-sectional study
    Jan P H Hamers
    Maastricht University, The Netherlands
    Int J Nurs Stud 46:248-55. 2009
    ....
  67. ncbi Perceptions of older people who have experienced physical restraint
    R Gallinagh
    University of Ulster, Jordanstown and United Hospitals, Antrim, Northern Ireland
    Br J Nurs 10:852-9. 2001
    ..However, the negative comments of the patients were more prevalent and their responses were categorized in terms of institutional control, ritualised care, entrapment and discomfort, and possible alternatives...
  68. ncbi Side rail use and bed-related fall outcomes among nursing home residents
    Elizabeth Capezuti
    School of Nursing and the Emory Center for Health in Aging, Emory University, Atlanta, GA 30329, USA
    J Am Geriatr Soc 50:90-6. 2002
    To analyze the effect of physical restraint reduction on nighttime side rail use and to examine the relationship between bilateral side rail use and bed-related falls/injuries among nursing home residents.
  69. ncbi Involvement of dynorphin in immobilization stress-induced antinociception in the mouse
    H W Suh
    Hallym University, College of Medicine, Institute of Natural Medicine, Department of Pharmacology, Chunchon, Kangwon Do, 200 702, South
    Eur Neuropsychopharmacol 10:407-13. 2000
    ..Our results suggest that supraspinally and spinally located dynorphin appears to be involved in the production of immobilization stress-induced antinociception via stimulating kappa-opioid receptors...
  70. ncbi Effect of repeated stress on novelty-induced antinociception in rats
    I L Torres
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 34:241-4. 2001
    ..These results suggest that repeated restraint stress induces an alteration in the nociceptive response, perhaps as a result of an alteration in endogenous opioids in these animals...
  71. ncbi Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants
    Nashat Abumaria
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Gottingen, 37077, Germany
    Cell Mol Neurobiol 28:331-42. 2008
    ..Expression of both TPH2 splice variants is not affected by stress, neither in DRN nor in the PiG. These data indicate that TPH1 in the serotonergic neurons of the DRN might be relevant for stress-induced psychopathologies...
  72. ncbi Adaptation to prolonged or repeated stress--comparison between rat strains showing intrinsic differences in reactivity to acute stress
    F S Dhabhar
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y 10021, USA
    Neuroendocrinology 65:360-8. 1997
    ..These differences under prolonged or repeated stress conditions may consequently magnify the behavioral and immunological differences observed between strains under basal as well as challenged conditions...
  73. ncbi Patient injury and physical restraint devices: a systematic review
    David Evans
    Department of Clinical Nursing, University of Adelaide, Adelaide, Australia
    J Adv Nurs 41:274-82. 2003
    To investigate physical restraint-related injuries. Areas of interest were the prevalence of injury, types of injuries, risk of sustaining an injury and specific restraint devices associated with injury.
  74. ncbi An updated national survey on seclusion and restraint
    W B Crenshaw
    Family Service and Guidance Center of Topeka, KS 66606, USA
    Psychiatr Serv 48:395-7. 1997
    ..Small positive correlations were found between seclusion and restraint and between the proportion of beds occupied by patients committed as criminally insane and the use of restrictive procedures...
  75. ncbi Consequences of an intervention to reduce restrictive side rail use in nursing homes
    Elizabeth Capezuti
    John A Hartford Foundation Institute for Geriatric Nursing, New York University College of Nursing, New York, New York 10003, USA
    J Am Geriatr Soc 55:334-41. 2007
    ..A secondary question explored the association between restrictive side rail reduction and bed-related falls...
  76. pmc Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity
    Erin E Young
    Department of Psychology, College of Liberal Arts, Texas A and M University College Station, TX 77843, United States
    J Neuroimmunol 220:79-89. 2010
    ..These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent...
  77. pmc Restraint stress fails to render C57BL/6 mice susceptible to Theiler's virus-induced demyelination
    Andrew J Steelman
    Department of Veterinary Integrative Biosciences, College of Liberal Arts, Texas A and M University, College Station, Tex, USA
    Neuroimmunomodulation 17:109-19. 2010
    ..Although its cause is unknown, multiple factors are thought to influence both the onset and exacerbation of the disease, including both genetic background as well as environmental factors...
  78. ncbi A cluster-randomized trial of an educational intervention to reduce the use of physical restraints with psychogeriatric nursing home residents
    Anna R Huizing
    Health Care and Nursing Science, Maastricht University, Maastricht, The Netherlands
    J Am Geriatr Soc 57:1139-48. 2009
    ..To investigate the effects of an educational intervention on the use of physical restraints with psychogeriatric nursing home residents...
  79. ncbi Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala
    C V Dayas
    Department of Physiology, University of Queensland, Brisbane, QLD 4072, Australia
    Eur J Neurosci 11:2312-22. 1999
    ....
  80. ncbi Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells
    I Castagliuolo
    Division of Gastroenterology, Beth Israel Hospital, Harvard Medical School, Boston 02215, USA
    Am J Physiol 271:G884-92. 1996
    ..We conclude that CRF released during immobilization stress increases colonic transit via a neuronal pathway and stimulates colonic mucin secretion via activation of neurons and mast cells...
  81. ncbi Preventing the use of physical restraints on residents newly admitted to psycho-geriatric nursing home wards: a cluster-randomized trial
    Anna R Huizing
    Department of Health Care Studies, Section of Nursing Science, Maastricht University, The Netherlands
    Int J Nurs Stud 46:459-69. 2009
    ..Although there is an urgent need for restraint-free care, the number of randomized clinical trials on preventing or reducing physical restraints has been limited...
  82. pmc Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection
    Andrew J Steelman
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    Brain Behav Immun 23:830-43. 2009
    ..As T cells mediate viral clearance in this model, our data support the hypothesis that stress-induced immunosuppression may provide a mechanism for enhanced viral persistence within the CNS...
  83. ncbi Restraint use among nursing home residents: cross-sectional study and prospective cohort study
    Gabriele Meyer
    Unit of Health Sciences and Education, University of Hamburg, Hamburg, Germany
    J Clin Nurs 18:981-90. 2009
    ....
  84. ncbi The effect of physical restraints on fall rates in older adults who are institutionalized
    K S Dunn
    Oakland University, School of Nursing, Rochester, MI 48309-4401, USA
    J Gerontol Nurs 27:40-8. 2001
    ..Removing physical barriers from older adults and allowing freedom of movement may decrease the severity of injury sustained in a fall...
  85. pmc Does risk adjustment of the CMS quality measures for nursing homes matter?
    Dana B Mukamel
    University of California Irvine, Center for Health Policy Research, Irvine, California 92697 5800, USA
    Med Care 46:532-41. 2008
    ..The Centers for Medicare and Medicaid Services (CMS) publish a report card for nursing homes with 19 clinical quality measures (QMs). These measures include minimal risk adjustment...
  86. ncbi Adverse effects associated with physical restraint
    Wanda K Mohr
    Rutgers University, College of Nursing, Newark, New Jersey, USA
    Can J Psychiatry 48:330-7. 2003
    ..This paper reviews the literature concerning actual and potential causes of deaths proximal to the use of physical restraint.
  87. ncbi Physical restraint initiation in nursing homes and subsequent resident health
    John Engberg
    RAND Corporation, Pittsburgh, PA, USA
    Gerontologist 48:442-52. 2008
    It is widely believed that physical restraint use causes mental and physical health decline in nursing home residents. Yet few studies exist showing an association between restraint initiation and health decline...
  88. ncbi Sustained release of corticosterone in rats affects reactivity, but does not affect habituation to immobilization and acoustic stimuli
    Marit A C Tanke
    Graduate School of Behavioral and Cognitive Neuroscience, University of Groningen, University Center of Psychiatry, University Medical Center Groningen, The Netherlands
    Life Sci 83:135-41. 2008
    ..This implies that altered HPA-axis function in depressed patients may not be causally related to stress coping, but instead may influence the course of the disorder...
  89. ncbi Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats
    S Bhatnagar
    Department of Anaesthesiology, Abranson Building Ste 402, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Neuroendocrinol 18:13-24. 2006
    ....
  90. ncbi Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus
    T Mera
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Neuroscience 141:1069-86. 2006
    ..These results suggest that prolactin-releasing peptide is a potent and important mediator of the stress response in the brain through the hypothalamic paraventricular nucleus...
  91. ncbi Intracerebroventricular administration of corticotrophin-releasing hormone receptor antagonists produces different effects on hypothalamic pituitary adrenal responses to novel restraint depending on the stress history of the animal
    C Vining
    Department of Anesthesiology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuroendocrinol 19:198-207. 2007
    ..In summary, these results indicate that manipulations of the CRH receptor have different effects on HPA activity depending on the stress history of the animal...
  92. ncbi Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats
    Sergiu Fediuc
    School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    J Appl Physiol 100:1867-75. 2006
    ....
  93. ncbi Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis
    A B Francis
    Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 141:1503-15. 2006
    ....
  94. ncbi Corticosterone can act at the posterior paraventricular thalamus to inhibit hypothalamic-pituitary-adrenal activity in animals that habituate to repeated stress
    Azra Jaferi
    Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
    Endocrinology 147:4917-30. 2006
    ....
  95. ncbi [Effect of Jiawei Sini Decoction on HPA function of rats with restraint psychological stress]
    Ya fei Shi
    Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    Zhong Yao Cai 31:88-91. 2008
    ..To observe the effect of Jiawei Sini Decoction (JWSND) on HPA function of rats with restraint psychological stress and the pathway of thymus immunosuppressive function...
  96. pmc Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats
    John R Mantsch
    Department of Biomedical Sciences, Box 1881, Marquette University, Milwaukee, WI 53201 1881, USA
    Brain Res 1167:101-11. 2007
    ..The findings suggest that cocaine use produces persistent changes in individual responsiveness to stressors that may contribute to the addiction process...
  97. ncbi The nociceptin/orphanin FQ antagonist UFP-101 differentially modulates the glucocorticoid response to restraint stress in rats during the peak and nadir phases of the hypothalamo-pituitary-adrenal axis circadian rhythm
    J D Leggett
    Department of Anatomy, University of Bristol, Southwell Street, Bristol, UK
    Neuroscience 147:757-64. 2007
    ....
  98. ncbi Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 33:721-30. 2008
    ..Furthermore, chronic nicotine SA selectively cross-sensitized the HPA response to a novel stressor. These observations suggest that nicotine may selectively increase the HPA response to stressors in human smokers...
  99. ncbi Estrogen potentiates adrenocortical responses to stress in female rats
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Psychiatry North, ML 0506, Bldg 43, 2nd Floor, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Am J Physiol Endocrinol Metab 292:E1173-82. 2007
    ..These results suggest that enhanced adrenal sensitive to ACTH is an important physiological mechanism mediating E(2)-related glucocorticoid hypersecretion in stressed females...
  100. pmc Antagonism of corticotrophin-releasing factor receptors in the fourth ventricle modifies responses to mild but not restraint stress
    Joanna R Miragaya
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 295:R404-16. 2008
    ..Hindbrain CRFR do not appear to influence stress-induced corticosterone release in RRS rats...
  101. ncbi Characteristics of behavior and stress reactivity of the hypophyseal-adrenocortical system in rats with prenatal inhibition of testosterone metabolism
    S G Pivina
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 37:53-8. 2007
    ....

Research Grants65

  1. Physical Restraints and Therapy Disruption in Hospitals
    Ann Minnick; Fiscal Year: 2005
    ..death, fracture, aspiration and delirium) have been reported to be the direct or indirect result of physical restraint (PR)...
  2. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    Paul E Sawchenko; Fiscal Year: 2012
    ..We have found that acute exposure to an emotional stressor (physical restraint) elicits robust increases in tau phosphorylation (tau-P) in mouse hippocampus, a pivotal structure in ..
  3. Interaction Behaviors Effect on Nursing Care Quality of Older Adults in the ICU
    Marci Lee Nilsen; Fiscal Year: 2012
    ..the association between interaction behaviors and nursing care quality indicators (sedation use and level, physical restraint use, pain management, and unplanned device disruption);3) psychometrically evaluate an interaction behavior ..
  4. Patient Care Outcomes at End-of-Life for Older Adults in ICU
    Jennifer B Seaman; Fiscal Year: 2013
    ..to end-of-life (EOL) care;these include unrelieved pain, ICU-acquired pressure ulcers, heavy sedation and physical restraint use...
  5. CMS Nonpayment for Nosocomial Injury and Risk of Falls in Hospitals
    Ronald I Shorr; Fiscal Year: 2010
    ..The tertiary aims of this study are to determine: 3. The relationship between physical restraint use and the risk of patient falls at the level of the: 3a. nursing unit, and 3b. patient, and 4...
  6. CONSEQUENCES OF PHYSICAL RESTRAINTS
    Nicholas Castle; Fiscal Year: 2004
    ..BY APPLICANT): In nursing home inspections conducted by state licensure and certification agencies, a physical restraint is defined as a device that is attached and cannot be easily removed by the resident which restricts freedom ..
  7. USE OF PHYSICAL RESTRAINTS FOR ELDERLY PATIENTS
    Lorraine Mion; Fiscal Year: 1991
    ..b>Physical restraint is a common but increasingly controversial practice in the United States...
  8. DOT and fMRI Studies of Visual Perception and Imagery
    Giorgio Ganis; Fiscal Year: 2005
    ..important for healthy infants and young children, in which fMRI cannot easily be used without extreme physical restraint measures (e.g...
  9. Improving Communication with NonSpeaking ICU Patients
    MARY HAPP; Fiscal Year: 2007
    ..Primary covariates include severity of illness, level of consciousness, and physical restraint use...
  10. NEURODEVELOPMENTAL INSULTS AND SCHIZOPHRENIA
    RUSSELL POLAND; Fiscal Year: 2001
    ..the investigator proposes a characterization of the effects of prenatal stress in the form of repeated daily physical restraint of pregnant dams...
  11. HOSPTIAL STAFFING, PHYSICAL RESTRAINT & PATIENT OUTCOMES
    EILEEN SULLIVAN MARX; Fiscal Year: 2002
    ..It is hypothesized that hospital nurse staffing and organization affect the rate of physical restraint use, and that such use is associated with poorer outcomes at discharge...
  12. LONG-TERM SENSITIZATION AFTER ACUTE STRESSORS
    SEYMOUR ANTELMAN; Fiscal Year: 1993
    ..For example, a single exposure to either physical restraint of amphetamine (AM) can augment an animal's behavioral response to subsequent AM given one month later...
  13. A TREATMENT FOR EXCESS MOTOR DISABILITY IN THE AGED
    Edward Taub; Fiscal Year: 2007
    ..abstract_text> ..
  14. Randomized Controlled Trial of Pediatric CI Therapy
    Edward Taub; Fiscal Year: 2006
    ..abstract_text> ..
  15. The Influence of Staff Turnover on Quality
    Nicholas Castle; Fiscal Year: 2007
    ..We propose to use five well-accepted indicators of care quality in nursing homes. These are the rates of physical restraint use, urethral catheterization, pressure ulcers, psychoactive medication use, and persistent pain...
  16. EXAMINING NURSING HOME COMPARE
    Nicholas Castle; Fiscal Year: 2005
    ..abstract_text> ..
  17. Staffing Characteristics of Nursing Homes and Quality
    Nicholas Castle; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Effects of Aging on Cancellation Tasks
    VICTOR MARK; Fiscal Year: 2002
    ..The findings will provide normative data for future research to determine whether cancellation tests may be sensitive to functional decline in aging and neurologic disorders. ..
  19. Cognitive Screening for CI Therapy after Stroke
    VICTOR MARK; Fiscal Year: 2004
    ....
  20. INCIDENT REPORTING IN NURSING HOMES
    Nicholas Castle; Fiscal Year: 2008
    ..This information will further our development of a standardized incident reporting mechanism recommended by the Institute of Medicine and others. [unreadable] [unreadable] [unreadable]..
  21. Sex Differences in Hippocampal Synaptic Protein & mRNA
    Russell Romeo; Fiscal Year: 2005
    ..Finally, additional experiments will provide novel information on how exposure to steroid hormones during prenatal development sexually differentiates the ability of estrogen to affect hippocampal synapses. ..
  22. Mental Practice Dosing and Mechanisms in Stroke
    Stephen Page; Fiscal Year: 2006
    ..Identification of MP mechanisms of action and optimal dosing is fundamental to cost-effective, appropriate implementation of this promising, CAM, mind-body technique, and will enable a subsequent MP clinical trial. ..
  23. Prevention of Neck Injuries in Older Adults During Rear Motor Vehicle Collsions
    PAUL IVANCIC; Fiscal Year: 2009
    ..The proposed project will provide important research-based data that may form the basis for future safety standards and help to decrease the frequency and severity of neck injuries in older adults, thus benefiting society. ..
  24. EXTREMITY CONSTRAINT INDUCED THERAPY EVALUATION (EXCITE)
    Steven Wolf; Fiscal Year: 2004
    ..Primary outcome measures are a laboratory motor function test and amount of extremity use in the real world setting. Changes in psychosocial functioning will also be measured. ..
  25. Social Stress, GC Resistance and Innate Immunity
    John Sheridan; Fiscal Year: 2008
    ..4. Determine the effect of SDR on innate immunity and susceptibility to infectious disease. This study will elucidate the mechanisms of immunoregulation and host resistance to disease that are altered by social stress. ..
  26. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  27. Stress Response Differences in Females: Estradiol's Role
    Martha Faraday; Fiscal Year: 2003
    ..abstract_text> ..
  28. MOLECULAR BIOLOGY OF NOREPINEPHRINE BIOSYNTHESIS
    Esther Sabban; Fiscal Year: 2006
    ..These findings will contribute to the development of new strategies to prevent the harmful maladaptive changes in catecholamine neurotransmission, while enhancing its beneficial adaptive aspects ..
  29. Sympathetic Ganglia: New Target for ACTH with Stress
    Esther Sabban; Fiscal Year: 2008
    ..abstract_text> ..
  30. Phox2a/2b Function in the Mature Locus Coeruleus.
    Meng Yang Zhu; Fiscal Year: 2008
    ..This information may greatly facilitate the development of meaningful, testable therapeutic intervention for aging, PD, and AD. [unreadable] [unreadable] [unreadable]..
  31. Improved Methodology: A Factorial Survey Study
    Ruth Ludwick; Fiscal Year: 2003
    ..Descriptive statistics, regression, and a repeated measures within subjects ANOVA will be used to analyze the data. ..
  32. ALTERED ETHANOL EFFECTS ON OSTEOCALCIN NULL MUTANT MICE
    Patricia Patterson Buckendahl; Fiscal Year: 2006
    ....
  33. NASD Academic ED Collaborative - UC San Diego
    Theodore Chan; Fiscal Year: 2004
    ..UCSD ED investigators will be responsible for following up on difficult to reach) patients. Local data and survey results will be submitted to the R-25 and R-21 sites for analysis. ..
  34. Significance of Stress-Induced Hippocampal Atrophy
    CHERYL CONRAD; Fiscal Year: 2006
    ..abstract_text> ..
  35. Development and control of repetitive leg movements during embryonic development
    NINA BRADLEY; Fiscal Year: 2008
    ..We will accelerate the time to hatch by incubating eggs in constant light and delay time to hatch by incubating eggs in constant dark. [unreadable] [unreadable] [unreadable]..
  36. Stress Sensitization of CRF-Induced Withdrawal Behaviors
    George Breese; Fiscal Year: 2009
    ..New treatment strategies could emerge from such knowledge ..
  37. SYMPATHETIC NEURAL FUNCTION AND GLUCOCORTICOIDS
    DEBORAH SCHEUER; Fiscal Year: 2001
    ..The results will provide fundamental new knowledge of the mechanisms of glucocorticoid-mediated modulation of arterial pressure regulation. ..
  38. Nursing Homes Response to Quality Indictors Publication
    Dana Mukamel; Fiscal Year: 2008
    ..Statistical regression techniques will be used to analyze the data and test specific hypotheses. ..
  39. NEUROPHARMACOLOGY OF PRIMATE COGNITION
    MICHAEL TAFFE; Fiscal Year: 2002
    ..abstract_text> ..
  40. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  41. Multilevel Intervention to Improve Nursing Home Outcomes
    Marilyn Rantz; Fiscal Year: 2009
    ..Similarly, we will observe processes of care delivery before, during and after the multilevel intervention to describe the adoption of the care delivery strategies recommended in the intervention. ..
  42. Songbird Neurogenomics Initiative
    David F Clayton; Fiscal Year: 2010
    ..Moreover, the approach here may serve as a model for doing science on a community scale, embracing individual initiative but coordinating efforts to achieve a larger synergy. ..
  43. Legacy Intervention Family Enactment (LIFE): An Effectiveness Trial
    Rebecca Allen; Fiscal Year: 2009
    ....
  44. Dysregulation of Brain Stress Systems and of Relapse
    Friedbert Weiss; Fiscal Year: 2008
    ....
  45. Corticotropin Releasing Factor-Norepinephrine Interactions in Stress & Depression
    ADRIAN DUNN; Fiscal Year: 2008
    ..The results should establish a model and indicate the nature of the cerebral structures involved, so that we can subsequently test the feed-forward hypothesis [unreadable] [unreadable]..
  46. 2008 Genes and Behavior Gordon Research Conference
    David Clayton; Fiscal Year: 2007
    ..This conference will promote progress towards this understanding by bringing together experts working with a variety of organismal models, human populations and technical approaches. [unreadable] [unreadable] [unreadable]..
  47. Genetic Analysis of Stress Response on EtOH Sensitivity
    Clarissa Parker; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. User adjustable support surfaces for wheelchair comfort
    Douglas Hobson; Fiscal Year: 2004
    ..In sub-task 4, these results will be compiled and submitted for an STTR phase II work continuation. All of these sub-tasks will assist in meeting the overall goal ..
  49. Stress Effects on an Animal Model of Autoimmune Disease
    CHRISTABEL WELSH; Fiscal Year: 2005
    ..Clarifying how environmental stressors influence an individual's vulnerability to autoimmune disease may increase our understanding of diseases such as multiple sclerosis and thus lead to the development of therapeutic regimens. ..
  50. EXPERIENCE DEPENDENT CHANGES IN THE BRAIN
    David Clayton; Fiscal Year: 2003
    ..This program of basic research has fundamental applicability to issues of human health and disease, including various psychiatric conditions and learning disorders. ..
  51. 5-HT1A RECEPTOR/G PROTEIN COUPLING AND ADAPTATION
    Emanuel Meller; Fiscal Year: 2003
    ..abstract_text> ..
  52. COGNITIVE EFFECTS OF ALCOHOL IN PERI-ADOLESCENT MONKEYS
    MICHAEL TAFFE; Fiscal Year: 2006
    ..This exploratory study will provide evidence regarding the risks posed to cognition by heavy alcohol drinking in the peri-adolescent period. ..
  53. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
    ....
  54. Mineralocorticoid-R Control of HPA Stress Response
    THADDEUS PACE; Fiscal Year: 2003
    ..And finally, the role of MR in controlling HPA responding will be examined after a stressor has been experienced repeatedly, a situation previously shown to increase the number of brain MR. ..
  55. WAGES: Workplace Activity for Employee Goal Setting
    RODNEY DISHMAN; Fiscal Year: 2006
    ..The project will implement and rigorously evaluate a multilevel physical activity intervention that has potential for broad application to workplace health promotion. ..
  56. Collaborative Care of Depression in Nursing Homes
    Mark Snowden; Fiscal Year: 2006
    ....
  57. Task Practice Schedules to Enhance Recovery after Stroke
    Nicolas Schweighofer; Fiscal Year: 2006
    ..The hypothesis is that subjects with mild deficits benefit most from expanded variable practice, whereas subjects with moderate deficits benefit most from massed practice schedules. [unreadable] [unreadable]..
  58. FUNCTIONAL NEUROANATOMY OF MOVEMENT DISORDERS
    Lucy Brown; Fiscal Year: 2006
    ..The studies may provide clues to the function of the gene huntingtin, and define a target for therapeutic strategies. In addition, these studies address the plastic and proliferative capacity of the adult brain. ..
  59. PRENATAL ALCOHOL EXPOSURE AND PREMATURE AGING
    ROBERT MC GIVERN; Fiscal Year: 2002
    ..A potential relationship between prenatal exposure to subteratogenic levels of ethanol and an accelerated rate of aging has broad implications for NIH with regard to treatment, health education, and clinical services. ..
  60. FETAL ALCOHOL EXPOSURE--NEUROIMMUNE INTERACTIONS
    Anna Taylor; Fiscal Year: 2001
    ....
  61. VERY EARLY CONSTRAINT-INDUCED MOVEMENT THERAPY:STROKE
    Alexander Dromerick; Fiscal Year: 2004
    ....
  62. Effects of Short Chain Fatty Acids on Colonic Motility
    Toku Takahashi; Fiscal Year: 2009
    ..These results may provide a rational explanation as to how low concentrations of luminal SCFAs and stress contributes to the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS). ..
  63. CAREER DEVELOPMENT AWARD IN PEDIATRIC PSYCHOPHARMACOLOGY
    Andres Martin; Fiscal Year: 2004
    ..abstract_text> ..