Genomes and Genes
fetal tissue transplantation
Summary: Transference of fetal tissue between individuals of the same species or between individuals of different species.
Publications177 found, 100 shown here
- Diminished survival of mesencephalic dopamine neurons grafted into aged hosts occurs during the immediate postgrafting intervalC E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush-Presbyterian-St. Luke's Medical Center, Suite 200, 2242 West Harrison Street, Chicago, Illinois, 60612, USA
Exp Neurol 169:23-9. 2001....
- Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgeneK Sawamoto
Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
J Neurosci 21:3895-903. 2001..Together, these findings indicate that precursor cells harvested from the embryonic ventral mesencephalon can generate dopaminergic neurons able to restore function to the chemically denervated adult striatum...
- Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activationC B Hurelbrink
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Exp Neurol 171:46-58. 2001..This implies that strategies to improve dopaminergic cell survival in clinical programmes of transplantation for PD will need to target other pathways of cell death...
- A role for tumor necrosis factor alpha in death of dopaminergic neurons following neural transplantationDeborah J Clarke
Department of Human Anatomy and Genetics, South Parks Road, Oxford, United Kingdom
Exp Neurol 176:154-62. 2002..Use of this therapeutic antibody approach may offer significant improvements to neural transplantation as a treatment for PD...
- Dopaminergic neurons associate with blood vessels in neural transplantsDiana Casper
Department of Neurosurgery, Montefiore Medical Center and the Albert Einstein College of Medicine, New York, NY, USA
Exp Neurol 184:785-93. 2003..These patterns became more marked with time. Results suggest that rates and patterns of vascularization may be important determinants in the long-term survival of dopaminergic neurons...
- Bilateral human fetal striatal transplantation in Huntington's diseaseR A Hauser
Department of Neurology, University of South Florida, Tampa, FL 33606, USA
Neurology 58:687-95. 2002..Transplanted striatal cells have been demonstrated to survive, grow, establish afferent and efferent connections, and improve behavioral signs in animal models of Huntington's disease (HD)...
- Volume and differentiation of striatal grafts in rats: relationship to the number of cells implantedC Watts
MRC Cambridge Centre for Brain Repair, and the Department of Neurosurgery, University of Cambridge, UK
Cell Transplant 9:65-72. 2000..These results have important practical implications in determining the optimum number of LGE cells to implant and hence in the design of any surgical protocol for the clinical application of this technique...
- Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's diseaseI Reuter
Academic Department of Neuroscience, Kings College Hospital, London, UK
J Neurol Neurosurg Psychiatry 79:948-51. 2008..The other patient did not improve clinically or radiologically. Our results indicate that striatal transplantation in HD may be beneficial but further studies are needed to confirm this...
- Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's diseaseA E Rosser
School of Biosciences, Cardiff University, PO Box 911, Museum Av, Cardiff CF10 3US, Wales, UK
Cell Transplant 12:679-86. 2003....
- Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's diseaseIvar Mendez
Dalhousie University and Queen Elizabeth II Health Science Center, Division of Neurosurgery and Neuroscience, Halifax, Canada
Brain 128:1498-510. 2005....
- Towards a protocol for the preparation and delivery of striatal tissue for clinical trials of transplantation in Huntington's diseaseC Watts
MRC Cambridge Centre for Brain Repair, Department of Neurosurgery, University of Cambridge, UK
Cell Transplant 9:223-34. 2000..Strategies aimed at minimizing the variability of tissue preparation should reduce the variability of functional outcome of striatal transplantation observed in animal models of Huntington's disease...
- Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projectionsLachlan Thompson
Wallenberg Neuroscience Center, Department of Experimental Medical Research, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
J Neurosci 25:6467-77. 2005....
- Neural transplantation in Huntington's disease: the NEST-UK donor tissue microbiological screening program and review of the literatureM Farrington
Clinical Microbiology and Public Health Laboratory, Health Protection Agency and Addenbrooke s Hospital, Cambridge, UK
Cell Transplant 15:279-94. 2006..This article therefore presents a comprehensive, logical yet pragmatic screening program that could be employed in any clinical studies that use human fetal tissue for neurotransplantation...
- Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's diseaseC Watts
Academic Department of Neurosurgery, Addenbrooke s Hospital and the University of Cambridge, Cambridge, UK
Cell Transplant 12:697-704. 2003..Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible...
- Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivoJ Herrera
Keck Center for Tissue Engineering, University of Utah, Salt Lake City, Utah
Exp Neurol 171:11-21. 2001....
- Striatal neural grafting improves cortical metabolism in Huntington's disease patientsVéronique Gaura
URA CEA CNRS 2210, 4 Place du General Leclerc, 91401 Orsay Cedex, France
Brain 127:65-72. 2004..Our results demonstrate the usefulness of PET measurements of brain glucose metabolism in understanding the effects of foetal grafts in patients with Huntington's disease...
- Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's diseaseC S Lee
Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, Canada
Brain 123:1365-79. 2000....
- Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID miceM Castaing
INSERM U457, , Paris, France
Diabetologia 44:2066-76. 2001..Transplantation of human embryonic pancreas into NOD/scid mice is a useful model for understanding the development of the human pancreas during prenatal life...
- Dopamine release from nigral transplants visualized in vivo in a Parkinson's patientP Piccini
MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Nat Neurosci 2:1137-40. 1999..Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief...
- Long-term expression of beta-glucuronidase by genetically modified human neural progenitor cells grafted into the mouse central nervous systemDelphine Buchet
Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, Bat CERVI, Hopital de la Pitie Salpetriere, 83, Boulevard de l Hopital, 75013 Paris, France
Mol Cell Neurosci 19:389-401. 2002..This study therefore paves the way for the treatment of MPS VII by long-term delivery of the appropriate enzyme...
- Positron emission tomography after fetal transplantation in Huntington's diseaseSarah Furtado
Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
Ann Neurol 58:331-7. 2005..These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation...
- A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesionsC Dirk Keene
Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, 98104, USA
Acta Neuropathol 117:329-38. 2009..This report, for the first time, highlights the potential for graft overgrowth in a patient receiving fetal neural transplantation...
- Dyskinesia after fetal cell transplantation for parkinsonism: a PET studyYilong Ma
Center for Neurosciences, North Shore Long Island Jewish Research Institute and Department of Neurology, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
Ann Neurol 52:628-34. 2002..These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism...
- Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted fociR J Hardy
Brookdale Center for Molecular Biology, Mount Sinai Medical School, NY 10029, USA
Development 122:2059-69. 1996..By contrast, the differentiation of such cells into oligodendrocytes does occur in a restricted manner, consistent with local regulation of oligodendrocyte progenitor differentiation...
- The morphological development of neurons derived from EGF- and FGF-2-driven human CNS precursors depends on their site of integration in the neonatal rat brainA E Rosser
Cambridge Centre for Brain Repair, Cambridge, UK
Eur J Neurosci 12:2405-13. 2000..This is important for the application of such cells in CNS repair strategies, in particular neural transplantation...
- Neural transplantation for the treatment of Parkinson's diseaseAnders Bjorklund
Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Sweden
Lancet Neurol 2:437-45. 2003
- Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian ratsEleonora Maries
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N Chicago, IL 60064, USA
Neurobiol Dis 21:165-80. 2006..The onset of forelimb-facial stereotypy correlated with measures of increased graft function...
- A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseC Warren Olanow
Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Ann Neurol 54:403-14. 2003..Fetal nigral transplantation currently cannot be recommended as a therapy for PD based on these results...
- Fetal tissue transplantation for patients with Parkinson's disease: a database of published clinical resultsE D Clarkson
US Army Medical Research Institute in Chemical Defense, Aberdeen Proving Grounds, Maryland 21010 5400, USA
Drugs Aging 18:773-85. 2001..Current and future directions in fetal tissue transplantation research and replacements for fetal tissue are discussed.
- Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's diseaseD E Redmond
St Kitts Biomedical Research Foundation, St Kitts, West Indies
Neurobiol Dis 29:103-16. 2008..These studies provide data for the optimal time course, cell preparation and surgical targets for systematic examinations of both potential benefits and side effects of dopamine neuron cell transplantation in primate models of PD...
- Status of fetal tissue transplantation for the treatment of advanced Parkinson diseasePaul E Greene
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Neurosurg Focus 13:e3. 2002In the first double-blind, placebo-controlled randomized study of fetal tissue transplantation for the treatment of patients with advanced Parkinson disease (PD), investigators found that implanted dopaminergic tissue can produce ..
- Clinical neurotransplantation: core assessment protocol rather than sham surgery as controlGerard J Boer
Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Brain Res Bull 58:547-53. 2002..It is a challenge for the neuroscience community to develop CAPs for brain diseases that are eligible for neurotransplantation in the future...
- Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesiaThomas Carlsson
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
Neurobiol Dis 21:657-68. 2006..The results indicate that graft-induced dyskinesias in PD patients may be linked to single, small graft deposits that provide an uneven, patchy reinnervation of the putamen...
- Cell therapy in Parkinson's diseaseOlle Lindvall
Wallenberg Neuroscience Center and Lund Strategic Center for Stem Cell Biology and Cell Therapy, BMC A11, SE 221 84 Lund, Sweden
NeuroRx 1:382-93. 2004..The stem cell technology may provide a virtually unlimited source of DA neurons, but several scientific issues need to be addressed before stem cell-based therapies can be tested in PD patients...
- Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's diseaseDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
J Comp Neurol 464:172-9. 2003....
- Immunohistochemical and electron microscopic study of invasion and differentiation in spinal cord lesion of neural stem cells grafted through cerebrospinal fluid in ratSufan Wu
Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
J Neurosci Res 69:940-5. 2002....
- An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionalityCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 187:58-64. 2004..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation...
- Transplantation of neurospheres after granule cell lesions in rats: cognitive improvements despite no long-term immunodetection of grafted cellsHélène Jeltsch
LN2C, UMR 7521, CNRS Université Louis Pasteur, 12 rue Goethe, F 67000, Strasbourg, France
Behav Brain Res 143:177-91. 2003....
- IL-1 beta is released from the host brain following transplantation but does not compromise embryonic dopaminergic neuron survivalDeborah J Clarke
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
Brain Res 952:78-85. 2002..Modulation of IL-1 beta activity, therefore, will not offer significant improvements to neural transplantation as a treatment for PD...
- Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhageSang Wuk Jeong
Department of Neurology, Ilsan Paik Hospital, Inje University, Ilsan, Korea
Stroke 34:2258-63. 2003..We hypothesize that intravenously transplanted human neural stem cells (NSCs) can migrate and differentiate into neurons or glial cells, thereby improving functional outcome in ICH...
- [Transplantation of stem/progenitor cells of human brain into the brain of adult rats]M A Aleksandrova
Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
Ontogenez 34:167-73. 2003..Some growing nerve cells had long processes with growth cones. At the same time, some transplanted cells retained the undifferentiated state within one month after the implantation, as shown by the vimentin expression...
- Induction of operational tolerance to discordant dopaminergic porcine xenograftsLena C Larsson
Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
Transplantation 75:1448-54. 2003..Lymphocyte function antigen (LFA)-1 is an important costimulatory molecule for CD8+ T cells, and we hypothesize that blockade with anti-LFA-1 may enhance the efficacy of CTLA4Ig and anti-CD40L therapy...
- Trophic support of mouse inner ear by neural stem cell transplantationFukuichiro Iguchi
Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Japan
Neuroreport 14:77-80. 2003..These findings indicate that transplantation of neural stem cells can be a useful strategy for application of neurotrophins in inner ear...
- Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brainF Cicchetti
Neuroregeneration Laboratories, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
Exp Neurol 177:376-84. 2002..These studies indicate that more than one mechanism can mediate cell death during neural cell transplantation and that a combined treatment using caspase and complement inhibition can significantly improve cell survival...
- A multiple target neural transplantation strategy for Parkinson's diseaseArun Chander Ramachandran
Faculty of Medicine, Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
Rev Neurosci 13:243-56. 2002..A multiple target strategy may restore dopaminergic input to affected basal ganglia nuclei and improve outcomes of neural transplantation in Parkinson's disease...
- AAV2 vectors mediate efficient and sustained transduction of rat embryonic ventral mesencephalonE Lehtonen
Laboratory of Experimental Neurosurgery, ULB, Belgium
Neuroreport 13:1503-7. 2002..This method of gene delivery could prove useful to achieve local, continuous secretion of neurotrophic factors at physiologically relevant doses to treat Parkinson's disease...
- Cellular replacement therapy for Parkinson's disease--where we are today?D Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, USA
Neuroscientist 8:457-88. 2002..New sources of replacement cells and stem cells may provide additional advantages for the future. Full recovery from parkinsonism appears not only to be possible, but a reliable cell replacement treatment may finally be near...
- Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activationM Emgard
Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
J Neurochem 86:1223-32. 2003..The present results imply that grafted cells may be victims of either an early necrotic or a later apoptotic cell death and that there is substantial cell death as early as 90 min after implantation...
- Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's diseaseHitoshi Yamada
Yokohama Neurology Clinic and School of Medicine, Yokohama City University, 1 211 1 Mutsukawa, Minami Ku, Yokohama 232 0066, Japan
Ann Neurol 54:352-9. 2003..VHL gene transduction provides a new therapeutic approach for treatment of PD...
- Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsyMuddanna S Rao
Department of Surgery Neurosurgery Duke University Medical Center, Durham, NC 27710, USA
Neurobiol Dis 27:117-32. 2007..In contrast, HFCs treated and grafted with BNC or FC survive robustly in the chronically epileptic hippocampus, considerably reduce the frequency of SRMS and blunt the progression of chronic TLE...
- Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's diseaseLucy Anderson
Centre for Brain Repair and Department of Clinical Neurosciences, University Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Neurobiol Dis 27:133-40. 2007..This suggests that even in the absence of cell replacement strategies utilising immature progenitor cells could be of real therapeutic value...
- Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviourMarine Hovakimyan
Institute of Anatomy, Medical Faculty, University of Rostock, Germany
J Anat 209:721-32. 2006..To minimize donor tissue necessary for transplantation, further investigations will aim to enhance dopaminergic differentiation of transplanted cells in vivo...
- Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neuronsBrian T Terpstra
Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
J Neurosci Methods 166:13-9. 2007..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells...
- Pig xenografts to the immunocompetent rat brain: Survival rates using distinct neurotoxic lesions in the nigrostriatal pathway and two rat strainsR Robichon
INSERM UPVM U 421, Plasticité cellulaire et thérapeutique, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil Cedex, France
Exp Neurol 194:333-40. 2005..We conclude that the distinct neurotoxins and host rat strains used in our experimental design are not major factors influencing the rejection time-course of primary neural xenografts...
- Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a cotransplantation approach with fetal ventral mesencephalic cellsA K Agrawal
Developmental Toxicology Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226 001, India
Neurobiol Dis 16:516-26. 2004..The results suggest that cotransplantation of OECs and VMC may be a better approach for functional restoration in 6-OHDA-induced rat model of Parkinson's disease...
- Fate of cloned embryonic neuroectodermal cells implanted into the adult, newborn and embryonic forebrainK Demeter
Institute of Experimental Medicine of Hung Acad Sci, Budapest, Hungary
Exp Neurol 188:254-67. 2004..The data suggest that noncommitted, proliferating neuroectodermal progenitors can integrate into the brain tissue at time and site of tissue genesis...
- Comparison of embryonic stem cell-derived dopamine neuron grafts and fetal ventral mesencephalic tissue grafts: morphology and functionDavid M Yurek
Department of Surgery Neurosurgery, University of Kentucky College of Medicine, Lexington, KY 40536 0305, USA
Cell Transplant 13:295-306. 2004..These data suggest there are similarities and also distinct differences in the manner in which ESC and VM grafts interact with the denervated striatum...
- The cellular repair of the brain in Parkinson's disease--past, present and futureMark Sayles
Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Transpl Immunol 12:321-42. 2004..Here we review the progress made in neural transplantation, both in the laboratory and in the clinic with particular attention to the development of stem cell and xenogeneic tissue based therapy...
- Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoformsMarco Timmer
Department of Neuroanatomy, Center of Anatomy, OE 4140, Hannover Medical School, D 30623 Hannover, Germany
Exp Neurol 187:118-36. 2004..We propose that administration of HMW FGF-2 may be used to improve function in the rat Parkinson's disease model...
- Pleiotrophin promotes functional recovery after neural transplantation in ratsHideki Hida
Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Neuroreport 18:179-83. 2007..Interestingly, the effect of pleiotrophin on the survival was additive to that of glial-cell line-derived neutropic factor. These results revealed that pleiotrophin had effects on donor cells in neural transplantation in vivo...
- Comparison of pure and mixed populations of human fetal-derived neural progenitors transplanted into intact adult rat brainDarin J Messina
Program in Neuroscience, The Keck Center for Tissue Engineering, University of Utah, Salt Lake City, UT 84112, USA
Exp Neurol 184:816-29. 2003....
- Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: implications for clinical trials in Huntington's diseaseCarrie B Hurelbrink
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
Cell Transplant 12:687-95. 2003....
- The future of cell-based transplantation therapies for neurodegenerative disordersStanley E Lazic
Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
J Hematother Stem Cell Res 12:635-42. 2003..Finally we will discuss the prospect of using stem cells to deliver drugs and neurotrophic factors involved in neuroprotective and neuroreparative strategies in Parkinson's disease and other neurodegenerative conditions...
- Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?Curt R Freed
Departments of Medicine, Neurology, Psychiatry, and Neurosurgery Box, University of Colorado School of Medicine, 4200 East Ninth Avenue, C237, Denver, CO 80220, USA
J Neurol 250:III44-6. 2003..Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment...
- Protection of dopamine neurons by bone marrow stromal cellsAki Shintani
Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan
Brain Res 1186:48-55. 2007..The present data indicate that BMSC may be a potential donor source of cell-based regenerative therapy for PD where the progressive loss of the midbrain DA neurons takes place...
- Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplantsK Mukhida
Neural Transplantation Laboratory, Departments of Anatomy and Neurobiology and Surgery (Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
J Neurosci 21:3521-30. 2001..A multitarget transplant strategy aimed at optimizing dopaminergic reinnervation of the basal ganglia may be crucial in improving clinical outcomes in PD patients...
- Morphological changes in immunopositive cells of ionotropic glutamate receptor subunits during the development of transplanted fetal ventral mesencephalic neuronsYasushi Ishida
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki gun, 889 1692, Miyazaki, Japan
Brain Res 940:79-85. 2002..These results suggest that the ionotropic glutamate receptors have differential roles during the developmental period of the intrastriatal VM grafts...
- Astrocytes from cerebral cortex or striatum attract adult host serotoninergic axons into intrastriatal ventral mesencephalic co-graftsA Petit
, , , , , Canada H3C 3J7
J Neurosci 21:7182-93. 2001..It should now be feasible to identify the molecules expressed by cultured cortical or striatal, but not by ventral mesencephalic, astrocytes that have these tropic actions on 5-HT axons of the neostriatum...
- Retinal integration of grafts of brain-derived precursor cell lines implanted subretinally into adult, normal ratsK Warfvinge
Wallenberg Retina Center, Lund University Hospital, Lund, Sweden
Exp Neurol 169:1-12. 2001..Our results suggest that these and other similar neural cell lines could be very useful in the continuous experiments in models of retinal disorders to further assess both the cell replacement and ex vivo gene therapy approaches...
- [10 years of substitution therapy for neurodegenerative diseases using fetal neuron grafts: a positive outcome but with questions for the future]M Peschanski
INSERM U421, IM3, , ,
J Soc Biol 195:51-5. 2001..Obstacles foreseen for these two alternative ways of fetal neurons to be are identified and research laboratories are actively exploring ways to overcome them...
- Temporal changes in the neurotrophic environment of the denervated striatum as determined by the survival and outgrowth of grafted fetal dopamine neuronsDavid M Yurek
Department of Surgery Neurosurgery, University of Kentucky College of Medicine, Health Sciences Research Building, Lexington 40536 0305, USA
Brain Res 931:126-34. 2002..These data also correlate well with reports that the expression of several specific dopaminergic neurotrophic factors within the striatum increase following a neurotoxic lesion of the nigrostriatal pathway in young adult rats...
- Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's diseaseS Thobois
CERMEP et service de neurologie D, , 59, boulevard Pinel, Lyon, France
Neurophysiol Clin 31:321-40. 2001....
- Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projectionsUlrica Englund
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, S 221 84 Lund, Sweden
Exp Neurol 173:1-21. 2002..The extensive integration and differentiation of in vitro-expanded human neural progenitor cells indicate that multipotent progenitors are capable of responding in a regionally specific manner to cues present in the developing rat brain...
- N-acetylcysteine enhances production of dopaminergic neurons from mesencephalic-derived precursor cellsJ Rodriguez-Pallares
Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Neuroreport 12:3935-8. 2001..The results suggest that NAC is effective in the production of DA cells from precursors, and that this may be related to enhancement of generation and/or survival of DA cells...
- Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktailC E Helt
Department of Basic Science, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Exp Neurol 170:258-69. 2001....
- The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitroSamina S Riaz
Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, South Kensington, London, SW7 2AY, UK
Brain Res Dev Brain Res 136:27-34. 2002....
- Fetal striatal transplants restore electrophysiological sensitivity to dopamine in the lesioned striatum of rats with experimental Huntington's diseaseGuann Juh Chen
Department of Neurological Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
J Biomed Sci 9:303-10. 2002..In conclusion, our data demonstrate that fetal striatal transplants restore electrophysiological sensitivity to DA in the lesioned striatum of animals with experimental HD...
- Neuroscience. Versatile cells against intractable diseasesConstance Holden
Science 297:500-2. 2002
- [Effects of simultaneous transplant of foetal mesencephalic cells in the striatum and the subthalamic nucleus of hemiparkinsonian rats]N Pavón-Fuentes
Centro Internacional de Restauracion Neurologica CIREN, La Habana, 11300, Cuba
Rev Neurol 34:917-23. 2002..A series of data from pharmacological and physiological studies offer strong evidence that the dopamine released in these nuclei may play an important role in regulating the output nuclei of the basal ganglia...
- Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brainCecilia Lundberg
Wallenberg Neuroscience Center, Lund University, S 221 84, Sweden
Exp Neurol 175:370-87. 2002....
- A sequential intrastriatal dopaminergic graft strategy in the rodent model for Parkinson's disease: implications for graft survival and targetingK A Baker
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
Cell Transplant 11:185-93. 2002..These results are further discussed in relation to their important clinical implication for neural transplantation in PD...
- Ethical guidance on human embryonic and fetal tissue transplantation: a European overviewWert G de
Institute for Bioethics, Maastricht, The Netherlands
Med Health Care Philos 5:79-90. 2002..of regulations, guidelines and societal debates in eight member states of the EC about a) embryonic and fetal tissue transplantation (EFTT), and b) the use of human embryonic stem cells (hES cells) for research into cell therapy, ..
- [Human pluripotent stem cell and neural differentiation]Takafumi Wataya
Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
Brain Nerve 60:1165-72. 2008..Several studies on fetal tissue transplantation have revealed that quantity and purity of transplanted cells are necessary for recovery of symptoms...
- Anatomy and ethics: an exploration of some ethical dimensions of contemporary anatomyD G Jones
Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
Clin Anat 11:100-5. 1998..Furthermore, many issues of interest to anatomists, such as the mechanisms of organ and fetal tissue transplantation, the neurological bases of aging and dementia, and definitions of brain death, are best tackled by ..
- Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in ratsKarim Mukhida
Division of Neurosurgery, Department of Surgery, Cell Restoration Laboratory, Dalhousie Medical School, Halifax, Nova Scotia, Canada
Neurosurg Focus 24:E8. 2008b>Fetal tissue transplantation for Parkinson disease (PD) has demonstrated promising results in experimental and clinical studies...
- Neural fetal tissue transplantation. Should we do what we can do?M B Mahowald
Case Western Reserve University School of Medicine, Cleveland, Ohio
Neurol Clin 7:745-57. 1989The following factors are relevant to ethical considerations regarding fetal tissue transplantation for treatment of neurological disorders: the empirical status of human fetuses or abortuses, different purposes and sites of tissue ..
- Fetal tissue transplantation research and federal policy: a growing wall of separationJ C Fletcher
Department of Internal Medicine, University of Virginia, Charlottesville
Fetal Diagn Ther 5:211-25. 1990The federal moratorium on fetal tissue transplantation research is creating an ever growing wall of separation between public and private research...
- A preliminary psychosocial study of Parkinson's patients after fetal tissue transplantationFu In Tang
School of Nursing, National Yang Ming University, 155 Li Nong Street, Sec 2, Taipei 112, Taiwan ROC
J Nurs Res 10:1-14. 2002..some nursing suggestions especially educating the patients and family about the facts and outcome of fetal tissue transplantation are highly recommended...
- Placebos that harm: sham surgery controls in clinical trialsAlex John London
Department of Philosophy and Centre for the Advancement of Applied Ethics, Carnegie Mellon University, 135 Bakes Hall, Pittsburgh, PA 15213, USA
Stat Methods Med Res 11:413-27. 2002Recent debates over the use of sham surgery as a control for studies of fetal tissue transplantation for Parkinson's disease have focused primarily on rival interpretations of the US federal regulations governing human-subjects research...
- Lewy body pathology in fetal graftsYaping Chu
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
Ann N Y Acad Sci 1184:55-67. 2010..neurons, we performed postmortem analyses on six Parkinson's disease (PD) patients who had received fetal tissue transplantation 18-19 months, 4 years, and 14 years previously...
- The ethical use of fetal tissue for transplantation and researchM T Verklan
University of Pennsylvania, Philadelphia 19102
J Adv Nurs 18:1172-7. 1993..Should fetal tissue transplantation research proceed and, if so, under what conditions? This paper examines the issues related to the use ..
- Fetal tissue engineeringChristopher G B Turner
Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
Clin Perinatol 36:473-88, xii. 2009..Still, it was only in the last three decades that fetal tissue transplantation in people has started to lead to favorable outcomes, yet by and large anecdotally...
- The use of fetal tissue for therapeutic applicationsN Rojansky
Department of Obstetrics and Gynecology, Hadassah Medical Center, Ein Kerem, Hebrew University Medical School, Jerusalem, Israel
Int J Gynaecol Obstet 41:233-40. 1993..This review presents the theoretical background and recent research and clinical advances in fetal tissue transplantation, in the light of the current debate on its ethical and moral implications.
- Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cellsZheng Hu
Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA
Cell Mol Immunol 9:232-6. 2012..The potential use of these humanized mice in translational biomedical research is also discussed...
- Diabetes induces changes in glomerular development and laminin-beta 2 (s-laminin) expressionC K Abrass
Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Pathol 151:1131-40. 1997..These data show that hyperglycemia and insulin status influence laminin isoform expression and play important roles in mesangial development...
- Diminution of toxic copper accumulation in toxic milk mice modeling Wilson disease by embryonic hepatocyte intrasplenic transplantationZhu Shi
Department of Neurology, Nanfang Hospital, 1st Military Medical University, Guangzhou 510515, Guangdong Province, China
World J Gastroenterol 11:3691-5. 2005..To observe the therapeutic effect of intrasplenic transplantation with embryonic hepatocytes on amelioration of hereditary copper accumulation in toxic milk (TX) mouse modeling Wilson disease...
- No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenograftsW Heneine
HIV and Retrovirology Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 352:695-9. 1998..PERV is carried in the pig germline, and all recipients of porcine tissues or organs will be exposed to the virus...
- The 'more-abortions' objection to fetal tissue transplantationL Gillam
Centre for Human Bioethics, Monash University, Clayton, Vic, Australia
J Med Philos 23:411-27. 1998One common objection to fetal tissue transplantation (FTT) is that, if it were to become a standard form of treatment, it would encourage or entrench the practice of abortion...
- Human fetal islet transplantation in type 1 diabetics: comparison of immunological effects between multiple implantation regimensP B Djordjevic
Institut for Endocrinology, Diabetes, and Metabolic Diseases, Belgrade, Serbia and Montenegro
Transplant Proc 37:4440-5. 2005..The CD4/CD8 ratio increased as the C-peptide level decreased, peaking on day 90 at the time of a decrease in C-peptide. These results may be useful for clinical studies of HFIs for type 1 diabetic patients...
- Embryonic pig liver, pancreas, and lung as a source for transplantation: optimal organogenesis without teratoma depends on distinct time windowsSmadar Eventov-Friedman
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 102:2928-33. 2005....
- Efficient early and sustained transduction of human fetal mesencephalon using adeno-associated virus type 2 vectorsL Tenenbaum
Laboratory of Experimental Neurosurgery, Hopital Erasme, ULB, Belgium
Cell Transplant 13:565-71. 2004..These results suggest that AAV2 vectors could be used to genetically modify the human fetal tissue prior to transplantation to Parkinson's patients to promote graft survival and integration...
Research Grants101 found, 100 shown here
- AXONAL GROWTH IN THE CHRONICALLY INJURED SPINAL CORDJOHN HOULE; Fiscal Year: 2003..The second aim will determine if a combination of neurotrophic factors and fetal tissue transplantation can increase axonal growth from a PN graft, into the spinal cord...
- CHIMERIC KIDNEYMARC HAMMERMAN; Fiscal Year: 2001..Since transplanted metanephroi appear to be less immunogenic than adult kidneys, our studies will provide insight into the feasibility of a novel means of renal transplantation that could be applied to humans. ..
- Neural Grafts and Injury-Induced Hippocampal DysfunctionAshok Shetty; Fiscal Year: 2009..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
- CHIMERIC KIDNEYMARC HAMMERMAN; Fiscal Year: 2003..Our studies will provide insight into the physiology and feasibility of a novel means of renal transplantation that could be applied to humans. ..
- CORE--ORGAN CULTURE AND TISSUE PROCESSING FACILITYMARC HAMMERMAN; Fiscal Year: 2002..The centralization of maintaining metanephric organ culture and tissue processing will assure uniformity and reproducibility of observations made in separate laboratories. ..
- Behavior of Stem Cells in the Lesioned Aging HippocampusAshok Shetty; Fiscal Year: 2006..abstract_text> ..
- RENAL DISEASEMARC HAMMERMAN; Fiscal Year: 2007..abstract_text> ..
- Washington University Center for Kidney Disease ResearchMARC HAMMERMAN; Fiscal Year: 2007..One (Kidney Translational Research Core) will be a regional St. Louis city-wide Core based at WU and also via subcontract at St. Louis' other academic medical center, St. Louis University. ..
- Repair of Chronially Injured Hippocampus by GraftsAshok Shetty; Fiscal Year: 2006..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. ..
- Neural Grafts and Injury-Induced Hippocampal DysfunctionAshok K Shetty; Fiscal Year: 2010..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
- DOUBLE-BLIND CONTROLLED TRIAL OF NIGRAL GRAFTING IN PDC Olanow; Fiscal Year: 2003..abstract_text> ..
- Multiple Factors Affecting Placebo Response in PDChristopher Goetz; Fiscal Year: 2004..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
- RECOVERY OF FUNCTION AFTER SPINAL CORD DAMAGEMarion Murray; Fiscal Year: 2005..abstract_text> ..
- EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISMCurt Freed; Fiscal Year: 2005..Brains will be stained with H+E and immunostained for tyrosine hydroxylase and B and T cell markers. Stereologically corrected counts of TH-positive neurons will be determined. ..
- In Utero Stem Cell Transplantation for Hemophilia AGraca Almeida Porada; Fiscal Year: 2006..abstract_text> ..
- Stem Cell Adaptability in Parkinson' DiseaseDAVID YUREK; Fiscal Year: 2009..The variable of host age on ESC-derived dopamine neuron adaptability will be studied. ..
- Investigation of the Placebo Effect in a Longitudinal Double-Blind Surgical TrialCynthia McRae; Fiscal Year: 2007....
- Functional Analysis of the Hematopoietic Niche during OntogenyGRACA DUARTE ALMEIDA PORADA; Fiscal Year: 2010..This would significantly improve the safety and success of clinical HSC transplantation and potentially allow its application to a wider range of diseases affecting human patients. ..
- Stem Cell Adaptability in Parkinson' DiseaseDAVID YUREK; Fiscal Year: 2007..The variable of host age on ESC-derived dopamine neuron adaptability will be studied. ..
- Functional Analysis of the Hematopoietic Niche during OntogenyGraca Almeida Porada; Fiscal Year: 2009..This would significantly improve the safety and success of clinical HSC transplantation and potentially allow its application to a wider range of diseases affecting human patients. ..
- Evaluation of Stem Cell Plasticity In VivoGraca Almeida Porada; Fiscal Year: 2004..With these studies we hope to provide novel insights into the location of latent stem cell poois within the body and define the behavior and capabilities of these cells that are potentially of great clinical value. ..
- Gene Therapy, Neural Grafts & Parkinson's DiseaseDAVID YUREK; Fiscal Year: 2005..These studies will also determine if combinations of viral vectors expressing different neurotrophic factors can be used to improve the therapeutic effects of dopamine grafts. ..
- Stem Cells for Neonatal Hypoxic-Ischemic Brain InjuryCesario Borlongan; Fiscal Year: 2007....
- PTEN Anti-Oncogene Influences on Neuronal Function & ToxicityMichael Kaplitt; Fiscal Year: 2007..abstract_text> ..
- Selective Prenatal Dopamine Damage in Non Human PrimatesJohn Elsworth; Fiscal Year: 2003..Thus, the proposed work may lead ultimately to an animal model for one or more pediatric brain disorders. ..
- ACUTE REPAIR OF SPINAL INJURY WITH FUSOGENSRichard Borgens; Fiscal Year: 2002..An anatomical evaluation of the degree of axonal repair between control and PEG treated spinal cords using a horseradish peroxidase dye exclusion test and conventional histology. ..
- Regulation of murine neonatal Th2 functionREBECCA D ADKINS; Fiscal Year: 2010..This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
- An Open Resource for Autism iPSCs and Their DerivativesPhilip Schwartz; Fiscal Year: 2009....
- Combined OEG transplantation and step training promote regeneration in adult SCIV Edgerton; Fiscal Year: 2009..Our long term goal is to regain voluntary control of hindlimb stepping after a complete midthoracic spinal cord injury in an adult animal. ..
- GENE THERAPY IN INDUCTION OF TRANSPLANT TOLERANCEIra Fox; Fiscal Year: 2002....
- LAMININ IN DEVELOPING GLOMERULAR BASEMENT MEMBRANESDale Abrahamson; Fiscal Year: 2003..These studies will provide fundamentally new information on glomerular development and maintenance. ..
- Molecular Regulation of Cell Development and DifferentiationDale Abrahamson; Fiscal Year: 2007..Together with the Administrative Core A, there will be Cores supporting transgenesis, gene targeting and genotyping (Core B), molecular profiling and recombin ..
- Regulation of murine neonatal Th2 functionREBECCA ADKINS; Fiscal Year: 2007..Therefore, Specific Aim 3 will address the hypothesis that RTE are the source of Th2 function in neonates. This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
- Heart Xenotransplantation with Chimeric Donor PigsWilliam Beschorner; Fiscal Year: 2006..Follow up studies would establish the relative contribution of tissue accommodation and specific immune tolerance to the prolongation of heart xenograft survival. ..
- Islet Transplantation with Chimeric Donor PigsWilliam Beschorner; Fiscal Year: 2006..These will permit earlier detection of rejection or graft failure, and establish the safety of xenotransplantation with regards to risk of zoonotic or opportunistic infections. ..