hematopoietic stem cell transplantation

Summary

Summary: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

Top Publications

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  2. ncbi LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    S Hacein-Bey-Abina
    INSERM Unit 429, Cedex 15, France
    Science 302:415-9. 2003
  3. ncbi Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    Nathalie Cartier
    INSERM UMR745, University Paris Descartes, 75279 Paris, France
    Science 326:818-23. 2009
  4. pmc Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    Nathalia Holt
    Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 28:839-47. 2010
  5. ncbi Hematopoietic stem-cell transplantation
    Edward A Copelan
    Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, USA
    N Engl J Med 354:1813-26. 2006
  6. pmc Graft-versus-host disease
    James L M Ferrara
    University of Michigan, Pediatrics and Internal Medicine, Blood and Marrow Transplantation Program, Ann Arbor, MI 48109 5942, USA
    Lancet 373:1550-61. 2009
  7. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
  8. pmc Reduced mortality after allogeneic hematopoietic-cell transplantation
    Ted A Gooley
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 363:2091-101. 2010
  9. pmc Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient
    Steven A Yukl
    San Francisco VA Medical Center and University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 9:e1003347. 2013
  10. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005

Detail Information

Publications325 found, 100 shown here

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  2. ncbi LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    S Hacein-Bey-Abina
    INSERM Unit 429, Cedex 15, France
    Science 302:415-9. 2003
    ..Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter...
  3. ncbi Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    Nathalie Cartier
    INSERM UMR745, University Paris Descartes, 75279 Paris, France
    Science 326:818-23. 2009
    ..Thus, lentiviral-mediated gene therapy of hematopoietic stem cells can provide clinical benefits in ALD...
  4. pmc Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    Nathalia Holt
    Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 28:839-47. 2010
    ..The demonstration that a minority of CCR5(-/-) HSPCs can populate an infected animal with HIV-1-resistant, CCR5(-/-) progeny supports the use of ZFN-modified autologous hematopoietic stem cells as a clinical approach to treating HIV-1...
  5. ncbi Hematopoietic stem-cell transplantation
    Edward A Copelan
    Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, USA
    N Engl J Med 354:1813-26. 2006
  6. pmc Graft-versus-host disease
    James L M Ferrara
    University of Michigan, Pediatrics and Internal Medicine, Blood and Marrow Transplantation Program, Ann Arbor, MI 48109 5942, USA
    Lancet 373:1550-61. 2009
    ..We also summarise supportive-care measures that are essential for management of this medically fragile population...
  7. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
    ..Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors...
  8. pmc Reduced mortality after allogeneic hematopoietic-cell transplantation
    Ted A Gooley
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 363:2091-101. 2010
    ..Over the past decade, advances have been made in the care of patients undergoing transplantation. We conducted a study to determine whether these advances have improved the outcomes of transplantation...
  9. pmc Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient
    Steven A Yukl
    San Francisco VA Medical Center and University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 9:e1003347. 2013
    ..The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure...
  10. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    ....
  11. pmc Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    Anthony E Boitano
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1345-8. 2010
    ..Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy...
  12. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  13. pmc Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation
    Ann M Leen
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, TX 77030, USA
    Blood 121:5113-23. 2013
    ..The use of banked third-party VSTs is a feasible and safe approach to rapidly treat severe or intractable viral infections after stem cell transplantation. This study is registered at www.clinicaltrials.gov as NCT00711035. ..
  14. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  15. ncbi Gene therapy for immunodeficiency due to adenosine deaminase deficiency
    Alessandro Aiuti
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    N Engl J Med 360:447-58. 2009
    ..We investigated the long-term outcome of gene therapy for severe combined immunodeficiency (SCID) due to the lack of adenosine deaminase (ADA), a fatal disorder of purine metabolism and immunodeficiency...
  16. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
  17. ncbi Competing risk analysis using R: an easy guide for clinicians
    L Scrucca
    Statistics Section, Department of Economy Finance and Statistics, University of Perugia, Perugia, Italy
    Bone Marrow Transplant 40:381-7. 2007
    ..We provide all the instructions for downloading it from internet and illustrate how to use it for analysis of a sample dataset of patients who underwent haematopoietic stem cell transplantation for acute leukaemia...
  18. ncbi Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    Derrick J Rossi
    Department of Pathology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 447:725-9. 2007
    ..These data are consistent with DNA damage accrual being a physiological mechanism of stem cell ageing that may contribute to the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury...
  19. pmc Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation
    Alessia Capotondo
    Division of Regenerative Medicine, Stem Cells and Gene Therapy, Vita Salute San Raffaele University, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 109:15018-23. 2012
    ....
  20. ncbi Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:1390-7. 2006
    ..Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was to study the effect of MSC infusion on graft-versus-host disease (GVHD)...
  21. pmc Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model
    Patrick M Younan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 122:179-87. 2013
    ..These data suggest that HSC protection may be a potential alternative to conventional antiretroviral therapy in patients with HIV/AIDS. ..
  22. ncbi Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
    Lynne M Ball
    Department of Pediatric Stem Cell Transplantation, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 110:2764-7. 2007
    ..These data suggest that MSCs, possibly thanks to their potent immunosuppressive effect on alloreactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure in haploidentical HSC transplant recipients...
  23. pmc Defining the intensity of conditioning regimens: working definitions
    Andrea Bacigalupo
    San Martino Hospital, Genoa, Italy
    Biol Blood Marrow Transplant 15:1628-33. 2009
    ..Standardized classification of conditioning regimen intensities will allow comparison across studies and interpretation of study results...
  24. ncbi Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
    Faiyaz Notta
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research Ontario Cancer Institute, Toronto, Ontario, Canada
    Science 333:218-21. 2011
    ..The demarcation of human HSCs and MPPs will enable the investigation of the molecular determinants of HSCs, with a goal of developing stem cell-based therapeutics...
  25. pmc Stem-cell gene therapy for the Wiskott-Aldrich syndrome
    Kaan Boztug
    Department of Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany
    N Engl J Med 363:1918-27. 2010
    ..Funded by Deutsche Forschungsgemeinschaft and others; German Clinical Trials Register number, DRKS00000330.)...
  26. ncbi Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Blood 117:3921-8. 2011
    ..This study provides evidence that Tregs are a conserved mechanism in humans...
  27. ncbi Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  28. ncbi Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
    ..The optimal MSC dose and frequency of administration to prevent or treat GVHD during allogeneic HSC transplantation should be evaluated further in phase II clinical trials...
  29. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
    ..of and risks for mould infections, we examined the records of 5589 patients who underwent hematopoietic stem cell transplantation at the Fred Hutchinson Cancer Research Center (Seattle) from 1985 through 1999...
  30. pmc Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    Paul W Denton
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 5:e16. 2008
    ..Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection...
  31. ncbi Dystrophin expression in the mdx mouse restored by stem cell transplantation
    E Gussoni
    Division of Genetics, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 401:390-4. 1999
    ..Our studies also suggest that the inherent developmental potential of stem cells isolated from diverse tissues or organs may be more similar than previously anticipated...
  32. ncbi Stem cell repopulation efficiency but not pool size is governed by p27(kip1)
    T Cheng
    Massachusetts General Hospital AIDS Research Center, Harvard Medical School, 149 13th Street, Room 5212 Boston, Massachusetts 02129, USA
    Nat Med 6:1235-40. 2000
    ..Modulating p27 expression in a small number of stem cells may translate into effects on the majority of mature cells, thereby providing a strategy for potentiating the impact of transduced cells in stem cell gene therapy...
  33. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  34. pmc Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
    Yohei Morita
    Division of Stem Cell Therapy and FACS Core Laboratory, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 207:1173-82. 2010
    ..These findings highlight the complexity and hierarchy of reconstitution capability, even among HSCs in the most primitive compartment...
  35. pmc Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation
    Ken Ichi Matsuoka
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 120:1479-93. 2010
    ..These studies indicate that CD4+ lymphopenia is a critical factor in Treg homeostasis and that prolonged imbalance of Treg homeostasis after HSCT can result in loss of tolerance and significant clinical disease manifestations...
  36. pmc Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    Isabel Beerman
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5465-70. 2010
    ..Finally, we present data supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging...
  37. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  38. ncbi Palifermin for oral mucositis after intensive therapy for hematologic cancers
    Ricardo Spielberger
    City of Hope National Medical Center, Department of Hematology and Hematopoietic Cell Transplantation and Kaiser Permanente BMT Program, Duarte, Calif 91010, USA
    N Engl J Med 351:2590-8. 2004
    ..We tested the ability of palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy...
  39. ncbi HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    Jennifer Antonchuk
    Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, V5Z 1L3, Vancouver, British Columbia, Canada
    Cell 109:39-45. 2002
    ..Importantly, these HSCs retained full lympho-myeloid repopulating potential and enhanced in vivo regenerative potential, demonstrating the feasibility of achieving significant ex vivo expansion of HSCs without functional impairment...
  40. pmc Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    Heather E Fleming
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 2:274-83. 2008
    ..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells...
  41. ncbi Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir
    N Symeonidis
    Department of Medicine, Memorial Sloan Ketterring Cancer Center, New York, New York 10021, USA
    Transpl Infect Dis 9:108-13. 2007
    ..Cidofovir is currently being increasingly used for treatment of adenoviral infections after HSCT. The efficacy of cidofovir in patients with invasive adenoviral infection is not established...
  42. ncbi Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
    Willy A Noort
    Department of Hematology, Leiden University Medical Center, Leiden University Medical Center, The Netherlands
    Exp Hematol 30:870-8. 2002
    ..In cotransplantation experiments, we examined the homing of MSC as well as the effect on engraftment of human umbilical cord blood (UCB)-derived CD34(+) cells in NOD/SCID mice...
  43. ncbi New perspectives on the biology of acute GVHD
    S Paczesny
    Department of Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Bone Marrow Transplant 45:1-11. 2010
    ..Herein, we provide a novel perspective on the immunobiology of acute GVHD and briefly discuss some of the outstanding questions and limitations of the model systems...
  44. ncbi Immunomodulation by mesenchymal stem cells and clinical experience
    K Le Blanc
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 262:509-25. 2007
    ..Possible clinical applications include therapy-resistant severe acute graft-versus-host disease, tissue repair, treatment of rejection of organ allografts and autoimmune disorders...
  45. pmc Hematopoietic-stem-cell-based gene therapy for HIV disease
    Hans Peter Kiem
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cell Stem Cell 10:137-47. 2012
    ..Here, we review this and other strategies for HSC-based gene therapy for HIV disease...
  46. ncbi A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    Darin K Fogg
    INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France
    Science 311:83-7. 2006
    ..Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS...
  47. ncbi European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3--2009 update
    J Maertens
    Department of Hematology, Leukemia and Stem Cell Transplantation Unit, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
    Bone Marrow Transplant 46:709-18. 2011
    ....
  48. ncbi Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells
    Katsuto Takenaka
    Division of Cellular and Molecular Biology, University Health Network, Toronto, Ontario M5G2M9, Canada
    Nat Immunol 8:1313-23. 2007
    ..Thus, we have identified Sirpa polymorphism as a potent genetic determinant of the engraftment of human hematopoietic stem cells...
  49. pmc Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans
    Fabio Candotti
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 120:3635-46. 2012
    ..on ERT because of poor gene marking and immune recovery, and one had a subsequent allogeneic hematopoietic stem cell transplantation. These studies directly demonstrate the importance of providing nonmyeloablative ..
  50. ncbi Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation
    Emmanuel Clave
    Assistance Publique Hopitaux de Paris, Inserm Unite Mixte de Recherche, Institut Universitaire d Hematologie, Universite Paris, Diderot, France
    Blood 113:6477-84. 2009
    Long-term T-cell reconstitution after hematopoietic stem cell transplantation (HSCT) is dependent on patient thymic function and affected by graft-versus-host disease (GVHD)...
  51. pmc Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
    Brad Dykstra
    Department of Cell Biology, European Research Institute on the Biology of Aging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, Netherlands
    J Exp Med 208:2691-703. 2011
    ....
  52. pmc Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation
    Ying Taur
    Infectious Disease Service, Department of Medicine, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Clin Infect Dis 55:905-14. 2012
    Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It is unclear whether changes in the intestinal microbiota during allo-HSCT contribute to the development of bacteremia...
  53. pmc Hematopoietic stem cell transplantation: a global perspective
    Alois Gratwohl
    European Group for Blood andMarrow Transplantation, Transplant Activity Survey Office, Department of Hematology, University Hospital Basel, Basel, Switzerland
    JAMA 303:1617-24. 2010
    b>Hematopoietic stem cell transplantation (HSCT) requires significant infrastructure. Little is known about HSCT use and the factors associated with it on a global level.
  54. ncbi Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    John E Wagner
    Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
    Blood 100:1611-8. 2002
    ..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less...
  55. pmc WU and KI polyomavirus infections in pediatric hematology/oncology patients with acute respiratory tract illness
    Suchitra Rao
    Department of Pediatrics, B158 The Children s Hospital and University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Clin Virol 52:28-32. 2011
    ..Other polyomaviruses (BKPyV and JCPyV) have been associated with illness in immunocompromised patients, and some studies suggest a higher prevalence of WUPyV and KIPyV in this population...
  56. ncbi Immune monitoring with iTAg MHC Tetramers for prediction of recurrent or persistent cytomegalovirus infection or disease in allogeneic hematopoietic stem cell transplant recipients: a prospective multicenter study
    Jan W Gratama
    Department of Clinical and Tumor Immunology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Blood 116:1655-62. 2010
    ..004). CMV tetramer-based immune monitoring, in conjunction with virologic monitoring, can be an important new tool to assess risk of CMV-related complications and to guide preemptive therapeutic choices...
  57. pmc Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, England, UK
    J Exp Med 206:371-85. 2009
    Animal models of hematopoietic stem cell transplantation have been used to analyze the turnover of bone marrow-derived cells and to demonstrate the critical role of recipient antigen-presenting cells (APC) in graft versus host disease (..
  58. pmc Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
    M A Eglitis
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:4080-5. 1997
    ..Other marrow-derived cells surprisingly expressed the astroglial marker glial fibrillary acidic protein. These results indicate that some microglia and astroglia arise from a precursor that is a normal constituent of adult bone marrow...
  59. ncbi Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential
    David G Kent
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Blood 113:6342-50. 2009
    ..These findings establish the identity of a phenotypically and molecularly distinct class of pluripotent hematopoietic cells with lifelong self-renewal capacity...
  60. ncbi Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Biol Blood Marrow Transplant 11:321-34. 2005
    ..They are also of potential use in the treatment of organ transplant rejection and in autoimmune inflammatory bowel disorders where immunomodulation and tissue repair are needed...
  61. pmc Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation
    Michael A Brehm
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Immunol 135:84-98. 2010
    ..Our data define key parameters for establishing humanized mouse models to study human immunity...
  62. pmc The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets
    Hans B Sieburg
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92112, USA
    Blood 107:2311-6. 2006
    ..These data from the steady-state HSC repertoire could provide a basis for the diagnosis of perturbed patterns of HSCs potentially caused by disease or aging...
  63. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  64. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  65. pmc Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 107:13022-7. 2010
    ....
  66. ncbi Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome
    Alain Chapel
    Institut de Radioprotection et de Surete Nucleaire, IRSN DPHD SARAM, Fontenay aux Roses, France
    J Gene Med 5:1028-38. 2003
    ..We investigated the potential of a combined infusion of autologous ex vivo expanded hematopoietic cells with mesenchymal (MSCs) for the treatment of multi-organ failure syndrome following irradiation in a non-human primate model...
  67. ncbi Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial
    M L MacMillan
    Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 43:447-54. 2009
    ..This encouraging safety profile with haploidentical MSCs supports the investigation of unrelated 'off the shelf' allogeneic HLA-mismatched MSC products...
  68. pmc Allogeneic haematopoietic stem cell transplantation in patients with human immunodeficiency virus: the experiences of more than 25 years
    G Hutter
    Institute of Transfusion Medicine and Immunology, Heidelberg University, Mannheim, Germany
    Clin Exp Immunol 163:284-95. 2011
    ..In this paper the data of more than 25 years experience with allogeneic HSCT in patients with HIV-1 are reviewed and analysed...
  69. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
    ....
  70. ncbi Management of RSV infections in adult recipients of hematopoietic stem cell transplantation
    Jharna N Shah
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 117:2755-63. 2011
    ..RSV) is a common cause of seasonal respiratory viral infection in patients who have undergone hematopoietic stem cell transplantation. RSV usually presents as an upper respiratory tract infection in this patient population but may ..
  71. ncbi Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia
    S Mizuta
    Department of Hematology, Fujita Health University Hospital, Toyoake, Aichi, Japan
    Leukemia 25:41-7. 2011
    ..However, the overall effect of imatinib on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is undetermined...
  72. ncbi Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    Charles E Murry
    Department of Pathology, Box 357470, Room D 514 HSB, University of Washington, Seattle, Washington 98195, USA
    Nature 428:664-8. 2004
    ..These results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair...
  73. pmc Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells
    Ivan Maillard
    Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 2:356-66. 2008
    ..Furthermore, Notch target genes were expressed at low levels in primitive hematopoietic progenitors. Taken together, these results rule out an essential physiological role for cell-autonomous canonical Notch signals in HSC maintenance...
  74. ncbi Allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
    Rafael F Duarte
    Department of Hematology, ICO Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain
    J Clin Oncol 28:4492-9. 2010
    ....
  75. pmc Strategies to enhance umbilical cord blood stem cell engraftment in adult patients
    Colleen Delaney
    Fred Hutchinson Cancer Research Center, Mailstop D2 100, 1100 Fairview Ave N, PO Box, 9024, Seattle, WA 98109, USA
    Expert Rev Hematol 3:273-83. 2010
    ..This article will focus on ex vivo expansion of UCB HSCs and strategies to enhance UCB homing as potential solutions to overcome the problem of low stem cell numbers in a UCB graft...
  76. ncbi Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation
    Lorenzo Moretta
    Giannina Gaslini Institute, Genova Quarto, Italy
    Blood 117:764-71. 2011
    ..In an allogeneic setting, such as T cell-depleted haploidentical hematopoietic stem cell transplantation, NK cells may express inhibitory killer immunoglobulin-like receptors that are not engaged by any ..
  77. ncbi Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
    John F DiPersio
    Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 113:5720-6. 2009
    ..This study is registered at www.clinicaltrials.gov as #NCT00103662...
  78. ncbi Long-term results of stem cell transplantation for MS: a single-center experience
    A Fassas
    Department of Hematology, Bone Marrow Transplantation and Gene and Cell Therapy Unit, Aristotle University of Thessaloniki Medical School, George Papanicolaou Hospital, Thessaloniki, Greece
    Neurology 76:1066-70. 2011
    ..To report long-term results of a phase I/II study conducted in a single center in order to investigate the effect of hemopoietic stem cell transplantation (HSCT) in the treatment of multiple sclerosis (MS)...
  79. ncbi Functional and phenotypic characterization of the humanized BLT mouse model
    A K Wege
    Department of Internal Medicine, Division of Infectious Diseases Y9 206, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9113, USA
    Curr Top Microbiol Immunol 324:149-65. 2008
    ..Importantly, in these mice the T cells developed in the human thymic implant are capable of being activated by human antigen-presenting cells and mount potent human MHC-restricted T cell immune responses...
  80. ncbi Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality
    Arlo Upton
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    Clin Infect Dis 44:531-40. 2007
    ..The aim of this study was to determine the probability of survival and prognostic factors associated with outcomes over a long period of time...
  81. pmc Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- mice
    Kaori Sango
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    AIDS Res Hum Retroviruses 26:735-46. 2010
    ..This animal model can serve as a valuable in vivo model to study the efficacy of anti-HIV therapies...
  82. pmc Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells
    J L Christensen
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 98:14541-6. 2001
    ..Fetal liver HSCs are contained within Flk-2(-) and Flk-2(+) KTLS cells...
  83. pmc Mesenchymal stem cells in hematopoietic stem cell transplantation
    Minoo Battiwalla
    Department of Medicine, Roswell Park Cancer Institute, New York, New York, USA
    Cytotherapy 11:503-15. 2009
    ....
  84. ncbi Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation
    Anskar Y H Leung
    Department of Medicine, University of Hong Kong, China
    Clin Infect Dis 40:528-37. 2005
    Polyoma BK virus (BKV) is associated with hemorrhagic cystitis during hematopoietic stem cell transplantation (HSCT)...
  85. ncbi Hematopoietic-cell transplantation at 50
    Frederick R Appelbaum
    Clinical Research Division of the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    N Engl J Med 357:1472-5. 2007
  86. ncbi Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
    Kieren A Marr
    Fred Hutchinson Cancer Research Center Programs in Infectious Diseases and Long term Follow up, Seattle, WA 98109, USA
    Blood 100:4358-66. 2002
    ....
  87. ncbi Graft-versus-host disease
    Warren D Shlomchik
    Yale University School of Medicine, sections of Medical Oncology and Immunobiology, PO Box 208032, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 7:340-52. 2007
    ..This Review focuses on research in mouse models pursued to achieve this goal...
  88. ncbi Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1238-46. 2003
    ..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis...
  89. ncbi Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome
    Elizabeth M Kang
    Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 99:698-701. 2002
    ..These results suggest that nonmyeloablative allogeneic transplantation in the context of highly active antiretroviral therapy is feasible in patients with treatment-sensitive HIV infection...
  90. ncbi Protective conditioning for acute graft-versus-host disease
    Robert Lowsky
    Department of Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    N Engl J Med 353:1321-31. 2005
    ..Conditioning with total lymphoid irradiation plus antithymocyte serum protects mice against acute graft-versus-host disease (GVHD) after hematopoietic-cell transplantation. We tested this strategy in humans...
  91. ncbi Autologous stem cell transplantation for progressive multiple sclerosis: update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database
    R Saccardi
    BMT Unit Department of Hematology, Ospedale di Careggi, Florence, Italy
    Mult Scler 12:814-23. 2006
    ....
  92. ncbi Transplant outcomes in mucopolysaccharidoses
    Vinod K Prasad
    Division of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC 27710, USA
    Semin Hematol 47:59-69. 2010
    ..In contrast, allogeneic hematopoietic stem cell transplantation (HSCT) allows donor-derived, enzyme-producing cells to migrate to the brain and other organs to ..
  93. ncbi Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis
    Eyal Robenshtok
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    J Clin Oncol 25:5471-89. 2007
    ..Many studies have evaluated the role of antifungal prophylaxis in cancer patients, with inconsistent conclusions...
  94. ncbi Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma
    Koen Van Besien
    Lymphoma Working Committee, International Bone Marrow Transplant Registry Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    Blood 102:3521-9. 2003
    ..We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade...
  95. ncbi Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis
    Per Ljungman
    Department of Hematology, Huddinge University Hospital, SE 14186 Stockholm, Sweden
    Blood 102:4255-60. 2003
    ..Our data suggest that donor CMV status influences outcome of unrelated SCT. For a CMV-seropositive patient, a seropositive donor might be preferable...
  96. ncbi Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..Data regarding the outcome of cord-blood transplantation in adults are scant, despite the fact that these grafts are increasingly used in adults...
  97. ncbi Allogeneic hematopoietic stem cell transplantation for inherited disorders: experience in a single center
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:718-25. 2006
    Allogeneic hematopoietic stem cell transplantation (ASCT) is a possible cure for many inherited disorders.
  98. ncbi Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    D S Krause
    Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 105:369-77. 2001
    ..This finding may contribute to clinical treatment of genetic disease or tissue repair...
  99. ncbi Haematopoietic cell transplantation as immunotherapy
    F R Appelbaum
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D5-310, PO Box 19024, Seattle, Washington 98109-1024, USA
    Nature 411:385-9. 2001
    ..Recent advances in our understanding of the immunobiology of stem-cell engraftment, tolerance and tumour eradication are allowing clinicians to better harness this powerful effect...
  100. ncbi Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies
    Michael Boeckh
    University of Washington, Seattle, WA 81009, USA
    Biol Blood Marrow Transplant 9:543-58. 2003
    Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality after hematopoietic stem cell transplantation. Significant progress has been made in the prevention of CMV disease over the past decade, but prevention of late ..
  101. pmc Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates
    Brian C Beard
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Invest 120:2345-54. 2010
    ..These nonhuman primate studies closely model a clinical setting and should have broad applications for HSC gene therapy targeting human diseases of malignant, genetic, and infectious nature, including HIV...

Research Grants75

  1. Allogeneic Stem Cell Transplants for HPV+Cervical Cancer
    Alexander Fefer; Fiscal Year: 2003
    ..allogeneic adoptive T-cell immunotherapy in the context of non-myeloablative allogeneic hematopoietic stem cell transplantation (NST) for the treatment of non-hematologic malignancies...
  2. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is an established treatment for benign and malignant hemato- logic diseases in children...
  3. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is a therapeutic procedure that is used to treat advanced hematologic malignancies or other blood disorders...
  4. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..b>Hematopoietic stem cell transplantation can reduce some manifestations, but has a 15% mortality rate, costs $130,000, and requires a ..
  5. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Long term, these findings have the potential to identify HSC transplantation, and not the transplantation of MSCs or progenitor cells, as the therapy of choice for this collagen disorder. ..
  6. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..Project Narrative Although hematopoietic stem cell transplantation is the only curative therapy for many blood-related disorders, associated risks often limit the ..
  7. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..UNMC and KUMC that collaborates on the conduct of clinical trials for autologous and allogeneic hematopoietic stem cell transplantation (HSCT)...
  8. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) has increased the survival of children and adults afflicted with malignant and non-malignant hematological diseases...
  9. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2013
    ..LAY SUMMARY: We will infuse CD19-specific T cells after transplantation to improve survival for patients with acute lymphoblastic leukemia. ..
  10. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..b>Hematopoietic stem cell transplantation (HSCT) is highly curative (up to 95% survival) only if the SCID infants are recognized early in ..
  11. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) can cure a variety of benign and malignant diseases but graft versus host disease (GvHD), mediated by donor T cells, remains a primary cause of ..
  12. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..This is particularly relevant for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who experience prolonged post-transplant T cell deficiency caused by cytoreductive ..
  13. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ..This is particularly relevan for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who experience prolonged post-transplant T cell deficiency caused by cytoreductive ..
  14. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic bone marrow or hematopoietic stem cell transplantation (allo BMT) is an important therapy with curative potential for a variety of malignant and non-malignant diseases...
  15. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for ..
  16. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
    ..Allogeneic hematopoietic stem cell transplantation is curative, although such a treatment typically requires an HLA-matched donor, is associated ..
  17. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Autologous hematopoietic stem cell transplantation (HSCT) has been an important treatment option for many patients with hematologic malignancies and solid tumors such as acute myeloid leukemia, ..
  18. Triplex-mediated DNA repair as a novel therapy for Hurler Syndrome patients
    Elizabeth Peterson-Roth; Fiscal Year: 2012
    ..Alternatively, allogeneic hematopoietic stem cell transplantation (HSCT) represents a highly effective treatment...
  19. Transplant Associated Infection Surveillance Network Phase II
    PETER GEORGE PAPPAS; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Organ and hematopoietic stem cell transplantation has become an increasingly important and life saving measure for thousands of persons each year ..
  20. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for many patients with hematologic malignancies and other blood disorders...
  21. Novel Immunodeficiency caused by TFRC Mutation
    RAIF SALIM GEHA; Fiscal Year: 2013
    ..analysis of cord blood lymphocytes for increased TfR1 surface expression, early intervention with hematopoietic stem cell transplantation (HSCT), and genetic counseling...
  22. Identification of Stromal Responses During Castration Mediated Thymic Regrowth
    ANN VENABLES GRIFFITH; Fiscal Year: 2011
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for ..
  23. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..We have shown that hematopoietic stem cell transplantation (HSCT) can increase C7 protein in skin and mucous membranes, and ameliorate many of the disease ..
  24. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ....
  25. IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..These studies will establish principles and practices for translating PET-based imaging of CAR+ T cells and provide the first human imaging data on the biodistribution of genetically modified T cells. ..
  26. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2013
    ..We believe that the information we derive can be directly translated to improve hematopoietic stem cell transplantation.Eicosanoids are physiological lipids that include prostaglandins, prostacyclins, thromboxanes, ..
  27. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
    ..training on developing a career as a physician/scientist with expertise in hematology/oncology, hematopoietic stem cell transplantation (HSCT) and human immunology...
  28. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2013
    ..training on developing a career as a physician/scientist with expertise in hematology/oncology, hematopoietic stem cell transplantation (HSCT) and human immunology...
  29. CD8+ T Cell Immunity to Cytomegalovirus
    Stanley R Riddell; Fiscal Year: 2013
    ..infection is a major cause of morbidity and mortality in patients who undergo allogeneic hematopoietic stem cell transplantation and require systemic corticosteroids to treat graft versus host disease...
  30. Phase 2 Study of Abatacept with Calcineurin Inhibition and Methotrexate for GVHD
    Leslie S Kean; Fiscal Year: 2013
    DESCRIPTION: (provided by the applicant) Hematopoietic stem cell transplantation (HSCT) often represents the only chance for cure for patients diagnosed with aggressive leukemias and other hematologic malignancies...
  31. Delta-like ligand 4+ dendritic cells and induction of alloimmunity
    Yi Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for many hematological malignancies resistant to other therapies...
  32. The role of Atg16L1 in Graft-Versus-Host-Disease
    VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a common therapeutic modality for a number of malignant diseases...
  33. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..to inhibit unwanted immune responses that occur during autoimmune disease or as a consequence of hematopoietic stem cell transplantation (HSCT) or tissue transplant rejection reactions...
  34. Post-transplant vaccines to enhance graft-versus-leukemia responses
    CATHERINE JU YING WU; Fiscal Year: 2013
    ..provided by applicant): A curative graft-versus-leukemia (GvL) response following allogeneic hematopoietic stem cell transplantation (HSCT) results from the: (1) restoration of normal immunity, thus overcoming leukemia- or ..
  35. H3K79 Methylation in Hematopoietic Stem Cell Development and MLL-Rearranged Leuk
    Kathrin M Bernt; Fiscal Year: 2013
    ..hematopoietic development and MLL-rearranged leukemia, while establishing an academic career in Hematopoietic Stem Cell Transplantation. I will build on my strong foundation in molecular biology and clinical hematology/oncology to ..
  36. NK and T Cell Regulation of ES-Derived Hematopoietic Progenitor Cell Engraftment
    WILLIAM TABAYOYONG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation is the most common cell-based immunotherapy in clinical application that has the potential to cure hematological malignancies and other hematopoietic disorders ..
  37. Chronic DTH and IFN-gamma in Human Graft Arteriosclerosis
    Jordan S Pober; Fiscal Year: 2010
    ..also develop new immunodeficient mouse models for analysis of human GA, exploiting advances in hematopoietic stem cell transplantation and tissue engineering of blood vessels...
  38. HSCT-induced changes that impair lung innate immunity
    Bethany B Moore; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is used to treat a variety of defects and malignancies, but its usefulness is limited by pulmonary infections...
  39. Mechanisms of T cell leukemia induction and maintenance
    Iannis Aifantis; Fiscal Year: 2013
    ..with relapsed disease continue to have dismal prognosis despite the use of protocols involving hematopoietic stem cell transplantation. T-ALL patients present at diagnosis with elevated white cell counts, hepatosplenomegaly, and are ..
  40. Immune Response to Polyomavirus Infection
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2012
    ..BKV also causes hemorrhagic cystitis which requires clinical intervention in about 5% of hematopoietic stem cell transplantation recipients. This grant will elucidate the humoral and cellular immune response to BKV infection...
  41. Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCT
    Helen E Heslop; Fiscal Year: 2013
    ..Viral infections remain a significant cause of failure in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT)...
  42. Role of the thymic epithelium on the outcome of allogeneic transplantation
    Konstantina Alexandropoulos; Fiscal Year: 2013
    ....
  43. Regulation of Systemic RNA Interference in the Nematode C. elegans
    JENNIFER SUNG WHANGBO; Fiscal Year: 2013
    ..silencing signals are transported between cells, while establishing an academic career in hematopoietic stem cell transplantation (HSCT) and gene-based therapies...
  44. Novel Cellular Therapies for Ph+ leukemia
    RICHARD A contact VAN ETTEN; Fiscal Year: 2010
    ..While BCR-ABL tyrosine kinase inhibitors (TKIs) such as imatinib mesylate have replaced hematopoietic stem cell transplantation (HSCT) as initial therapy for CML, complete molecular remissions are rare and acquired resistance ..
  45. Strategies to enhance immune reconstitution after bone marrow transplant
    Marcel R m van den Brink; Fiscal Year: 2013
    ..T cell deficiency, is an important contributor to morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, leading to infections and malignant relapse...
  46. GVL Resistance: Immune selection, T cell ignorance and T cell exhaustion
    Warren D Shlomchik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Donor T cells play a vital role in allogeneic hematopoietic stem cell transplantation (alloSCT). First, na?ve and pathogen-specific donor memory T cells (TM) protect recipients from infection...
  47. The Role of KIR and FcR Genotype in the Efficacy of mAb and IL2 Immunotherapy
    Paul M Sondel; Fiscal Year: 2013
    ..NK cells and KIR ligands on recipient tissues can influence anti-tumor efficacy of allogeneic hematopoietic stem cell transplantation (HSCT)...
  48. Stem Cell Transplantation in 2020: A Workforce and Infrastructure Assessment
    Edward Snyder; Fiscal Year: 2011
    ..This sustained 3-year initiative will provide momentum to drive change in health care policy and will allow adequate representation of national and regional stakeholders. ..
  49. Allogeneic stem cell transplant with grafts depleted of naive T cells for leukemi
    Marie Bleakley; Fiscal Year: 2013
    ..approaches to improve the disease-free survival of patients with leukemia that receive allogeneic hematopoietic stem cell transplantation (HCT)...
  50. Cincinnati Center for Excellence in Molecular Hematology
    Yi Zheng; Fiscal Year: 2013
    ..cell biology, basic research in signaling and clinical care in hematology, allergy/immunology and hematopoietic stem cell transplantation. This focus has been greatly strengthened by recruitment of over 50 faculty in these areas in the ..
  51. JC Virus Primary Infection, Latency, and Reactivation
    CHEN SABRINA TAN; Fiscal Year: 2013
    ..Decipher the impact of the cellular Immune response on JCV In Individuals undergoing allogeneic hematopoietic stem cell transplantation Dr...
  52. Graft versus Host Disease Biomarkers: Prediction of Onset and Response to Therapy
    Sophie Paczesny; Fiscal Year: 2010
    ..Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases but its clinical utility has been ..
  53. Insights into immune-related disease born from population genomics
    PETER R PARHAM; Fiscal Year: 2013
    ..as well as being major arbiters of transplant rejection, graft-versus- disease following hematopoietic stem cell transplantation, and pregnancy syndromes...
  54. The Role of Heme Metabolic Pathways in T Cell Development and T Cell Lymphomagene
    Mary Philip; Fiscal Year: 2013
    ..and facilities of the Fred Hutchinson Cancer Research Center, the leader in the study and use of hematopoietic stem cell transplantation and immunotherapy to treat cancers. In the long-term, Dr...
  55. Matched and Haploidentical transplantation for Adults with Sickle Cell Anemia
    Neal Flomenberg; Fiscal Year: 2010
    ..Reduced intensity approaches to allogeneic hematopoietic stem cell transplantation (HSCT) have been recognized as a tool for reducing morbidity and mortality to safe and acceptable ..
  56. AAV Mediated Gene Transfer to the CNS for MPS I
    R Scott McIvor; Fiscal Year: 2012
    ..MPS I is currently treated by enzyme replacement therapy (ERT) and by allogeneic hematopoietic stem cell transplantation (HSCT), but the neurologic effectiveness of these treatments is limited by the amount of IDUA ..
  57. Newborn Screening and Biomarkers for Mucopolysaccharidoses
    Shunji Tomatsu; Fiscal Year: 2013
    ..These MPS disorders are potentially treatable with enzyme replacement therapy or hematopoietic stem cell transplantation. The quality of life for MPS patients treated with these therapies dramatically improves when ..
  58. Novel Therapies for Globoid-Cell Leukodystrophy
    Mark S Sands; Fiscal Year: 2013
    ..The only currently available treatment for GLD is hematopoietic stem cell transplantation (HSCT) using either umbilical cord blood or allogeneic bone marrow...
  59. Notch Signaling in Alloimmunity
    Ivan Maillard; Fiscal Year: 2013
    ..Allogeneic T cell responses drive reactivity to foreign tissues in the setting of solid organ or hematopoietic stem cell transplantation (allo-HSCT)...
  60. IN UTERO STEM CELL TRANSPLANTATION
    Esmail Zanjani; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): In utero hematopoietic stem cell transplantation (IUSCT) is a promising therapeutic approach for many genetic disorders...
  61. Using game mechanics to improve outcomes among stem cell transplant survivors
    Dongsong Zhang; Fiscal Year: 2013
    Adolescent and young adult (AYA) hematopoietic stem cell transplantation (HSCT) patients face a variety of well-documented physical and emotional challenges...
  62. BAFF Pathology: Novel Therapeutic Targets in Chronic Graft versus Host Disease
    Stefanie Sarantopoulos; Fiscal Year: 2013
    ..Sarantopoulos to collect and characterize samples from patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT). In addition, Dr. Jerome Ritz from Dana-Farber Cancer Center, Dr...
  63. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2010
    ..transfer of hematopoietic precursors in mice and a clinically relevant model for allogeneic hematopoietic stem cell transplantation. Aim 1, will characterize the direct circulating precursor that repopulate skin resident LCs ..
  64. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is a successful treatment option for many patients with severe hematologic diseases...
  65. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..These neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  66. GM-CSF secreting tumor cell vaccines to enhance post-transplant anti-CLL immunity
    Catherine Wu; Fiscal Year: 2009
    ..destruction as demonstrated by observations of the graft-versus-leukemia (GvL) effect after hematopoietic stem cell transplantation and donor lymphocyte infusion (DLI)...
  67. Effect of recipient age /graft vs host disease post BMT
    RAYMOND HUTCHISON; Fiscal Year: 2001
    Murine models of hematopoietic stem cell transplantation will be utilized to investigate the association between advancing age and more severe graft-vs.-host disease (GVHD)...
  68. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2003
    DESCRIPTION: (Applicant's Abstract) Allogeneic hematopoietic stem cell transplantation (HSCT) is curative therapy for hematologic malignancies, aplastic anemia and a variety of genetic conditions; however, significant treatment-related ..
  69. Krabbe disease: Combined therapies for the central and peripheral nervous systems
    David A Wenger; Fiscal Year: 2010
    ..The only treatment currently available for some patients is hematopoietic stem cell transplantation (HSCT)...
  70. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    Over the past decade, the use of immune deficient mice as recipients for human hematopoietic stem cell transplantation has dramatically improved stem cell research...
  71. IL-12-Faciliated Hematopoietic Recovery Following Myeloablative Therapy
    Dan Douer; Fiscal Year: 2007
    ..provided by applicant): Intensive myeloablative cytotoxic treatment followed by autologous hematopoietic stem cell transplantation (HSCT) is frequently used in clinical practice to cure or improve survival of hematological ..
  72. Optimizing Nonmyeloablative Stem Cell Transplantation
    Marco Mielcarek; Fiscal Year: 2007
    ..have been impressed by the toxicities associated with conditioning regimens used for conventional hematopoietic stem cell transplantation (HSCT)...
  73. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..provided by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence...
  74. Strategy to Cure Type 1 Diabetes
    Zhiguang Guo; Fiscal Year: 2003
    Recent developments in hematopoietic stem cell transplantation provide a new therapeutic opportunity for treating type 1 diabetes...
  75. Ex Vivo Alloanergization to Improve Immunity After Haploidentical Transplant
    Eva C Guinan; Fiscal Year: 2010
    Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for many patients with malignant diseases. However, many patients lack HLA-matched donors, particularly those of minority or mixed race or ethnicity...