hematopoietic stem cell transplantation

Summary

Summary: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

Top Publications

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  2. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
  3. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
  4. ncbi Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
  5. ncbi Competing risk analysis using R: an easy guide for clinicians
    L Scrucca
    Statistics Section, Department of Economy Finance and Statistics, University of Perugia, Perugia, Italy
    Bone Marrow Transplant 40:381-7. 2007
  6. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
  7. ncbi Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
    John F DiPersio
    Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 113:5720-6. 2009
  8. ncbi Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
  9. ncbi Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
    Kieren A Marr
    Fred Hutchinson Cancer Research Center Programs in Infectious Diseases and Long term Follow up, Seattle, WA 98109, USA
    Blood 100:4358-66. 2002
  10. ncbi Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Biol Blood Marrow Transplant 11:321-34. 2005

Research Grants

  1. Allogeneic Stem Cell Transplants for HPV+Cervical Cancer
    Alexander Fefer; Fiscal Year: 2003
  2. Post-transplant vaccines to enhance graft-versus-leukemia responses
    CATHERINE JU YING WU; Fiscal Year: 2010
  3. Training Patients and Partners for HSCT: A Novel Coping Skills Intervention
    Catalina Lawsin; Fiscal Year: 2007
  4. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2011
  5. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    KATHERINE PONDER; Fiscal Year: 2009
  6. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2010
  7. Imaging Infused CD19 Specific T Cells in the Tumor
    LAURENCE COOPER; Fiscal Year: 2007
  8. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2010
  9. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2010
  10. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003

Detail Information

Publications250 found, 100 shown here

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  2. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  3. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  4. ncbi Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  5. ncbi Competing risk analysis using R: an easy guide for clinicians
    L Scrucca
    Statistics Section, Department of Economy Finance and Statistics, University of Perugia, Perugia, Italy
    Bone Marrow Transplant 40:381-7. 2007
    ..We provide all the instructions for downloading it from internet and illustrate how to use it for analysis of a sample dataset of patients who underwent haematopoietic stem cell transplantation for acute leukaemia...
  6. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
    ..of and risks for mould infections, we examined the records of 5589 patients who underwent hematopoietic stem cell transplantation at the Fred Hutchinson Cancer Research Center (Seattle) from 1985 through 1999...
  7. ncbi Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
    John F DiPersio
    Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 113:5720-6. 2009
    ..This study is registered at www.clinicaltrials.gov as #NCT00103662...
  8. ncbi Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
    ..The optimal MSC dose and frequency of administration to prevent or treat GVHD during allogeneic HSC transplantation should be evaluated further in phase II clinical trials...
  9. ncbi Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
    Kieren A Marr
    Fred Hutchinson Cancer Research Center Programs in Infectious Diseases and Long term Follow up, Seattle, WA 98109, USA
    Blood 100:4358-66. 2002
    ....
  10. ncbi Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Biol Blood Marrow Transplant 11:321-34. 2005
    ..They are also of potential use in the treatment of organ transplant rejection and in autoimmune inflammatory bowel disorders where immunomodulation and tissue repair are needed...
  11. ncbi Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation
    Michael A Brehm
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Immunol 135:84-98. 2010
    ..Our data define key parameters for establishing humanized mouse models to study human immunity...
  12. ncbi Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    Paul W Denton
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 5:e16. 2008
    ..Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection...
  13. ncbi Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    D S Krause
    Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 105:369-77. 2001
    ..This finding may contribute to clinical treatment of genetic disease or tissue repair...
  14. ncbi Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality
    Arlo Upton
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    Clin Infect Dis 44:531-40. 2007
    ..The aim of this study was to determine the probability of survival and prognostic factors associated with outcomes over a long period of time...
  15. ncbi Transplant outcomes in mucopolysaccharidoses
    Vinod K Prasad
    Division of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC 27710, USA
    Semin Hematol 47:59-69. 2010
    ..In contrast, allogeneic hematopoietic stem cell transplantation (HSCT) allows donor-derived, enzyme-producing cells to migrate to the brain and other organs to ..
  16. ncbi Mesenchymal stem cells in hematopoietic stem cell transplantation
    Minoo Battiwalla
    Department of Medicine, Roswell Park Cancer Institute, New York, New York, USA
    Cytotherapy 11:503-15. 2009
    ....
  17. ncbi Graft-versus-host disease
    Warren D Shlomchik
    Yale University School of Medicine, sections of Medical Oncology and Immunobiology, PO Box 208032, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 7:340-52. 2007
    ..This Review focuses on research in mouse models pursued to achieve this goal...
  18. ncbi Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells
    J L Christensen
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 98:14541-6. 2001
    ..Fetal liver HSCs are contained within Flk-2(-) and Flk-2(+) KTLS cells...
  19. ncbi Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- mice
    Kaori Sango
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    AIDS Res Hum Retroviruses 26:735-46. 2010
    ..This animal model can serve as a valuable in vivo model to study the efficacy of anti-HIV therapies...
  20. ncbi Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    ....
  21. ncbi Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..CONCLUSIONS: HLA-mismatched cord blood should be considered an acceptable source of hematopoietic stem-cell grafts for adults in the absence of an HLA-matched adult donor...
  22. ncbi Allogeneic hematopoietic stem cell transplantation for inherited disorders: experience in a single center
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:718-25. 2006
    Allogeneic hematopoietic stem cell transplantation (ASCT) is a possible cure for many inherited disorders.
  23. ncbi Immunomodulation by mesenchymal stem cells and clinical experience
    K Le Blanc
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 262:509-25. 2007
    ..Possible clinical applications include therapy-resistant severe acute graft-versus-host disease, tissue repair, treatment of rejection of organ allografts and autoimmune disorders...
  24. ncbi LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    S Hacein-Bey-Abina
    INSERM Unit 429, Cedex 15, France
    Science 302:415-9. 2003
    ..Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter...
  25. ncbi Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation
    Jo-Anne H van Burik
    University of Minnesota, Minneapolis, MN, USA
    Clin Infect Dis 39:1407-16. 2004
    ..would be an effective agent for antifungal prophylaxis during neutropenia in patients undergoing hematopoietic stem cell transplantation (HSCT)...
  26. ncbi Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
    V Rocha
    Eurocord-Cord Blood Transplant Group (CBTG) and Biostatistics Department, Saint Louis Hospital AP-HP, University of Paris 7, France
    Blood 97:2962-71. 2001
    ..39; 95CI: 0.97-1.99; P <.07). In conclusion, the use of UCBT, as a source of hematopoietic stem cells, is a reasonable option for children with AL lacking an acceptably matched unrelated marrow donor...
  27. ncbi Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    Charles E Murry
    Department of Pathology, Box 357470, Room D 514 HSB, University of Washington, Seattle, Washington 98195, USA
    Nature 428:664-8. 2004
    ..These results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair...
  28. ncbi Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice
    Prabal Banerjee
    Department Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA
    Blood 115:2640-8. 2010
    ..This animal model of ATLL will provide an important tool for the identification of molecular and cellular events that control the initiation and progression of the lymphoma and potential therapeutic targets to block tumor development...
  29. ncbi In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets
    Andreas Beilhack
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Blood 106:1113-22. 2005
    ..These findings underline the potential of T-cell subsets with defined trafficking patterns for immune reconstitution without the risk of GVHD...
  30. ncbi Bone loss following hematopoietic stem cell transplantation: a long-term follow-up
    Claudia M S Schulte
    Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany
    Blood 103:3635-43. 2004
    Transplantation-associated bone loss is a well-known phenomenon, however, effects of hematopoietic stem cell transplantation are insufficiently characterized...
  31. ncbi Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer
    Robert R Jenq
    Department of Immunology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Nat Rev Cancer 10:213-21. 2010
    ..We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies...
  32. ncbi Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation
    Claire Roddie
    UCL Cancer Institute, Department of Haematology, Paul O Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK
    Expert Opin Biol Ther 11:473-87. 2011
    INTRODUCTION: Allogeneic hematopoietic stem cell transplantation (SCT) is the treatment of choice for many malignant hematological disorders...
  33. ncbi Loss of neuronal integrity during progressive HIV-1 infection of humanized mice
    Prasanta K Dash
    Department of Pharmacology and Experimental Neuroscience, Radiology, Surgery, and Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:3148-57. 2011
    ..As such, the model permits studies of the relationships between ongoing viral replication and virus-associated neurodegeneration...
  34. ncbi Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
    Takashi Yahata
    Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Blood 118:2941-50. 2011
    ..The study reveals that ROS play a causative role for DNA damage and the regulation of ROS have a major influence on human HSC aging...
  35. ncbi Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation
    Desiree Caselli
    U O Cure Domiciliari Terapia Cellulare, Dipartimento di Oncoematologia, Azienda Ospedaliero Universitaria Meyer, Viale Pieraccini, 24 50139 Firenze, Italy
    Haematologica 95:1612-5. 2010
    ..Monitoring local bacterial isolates epidemiology is mandatory and will allow empiric antibiotic therapy to be tailored to reduce fatalities...
  36. ncbi Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation
    Jacques Donnez
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique IREC, Unité de Recherche GYNE, Department of Gynecology, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Fertil Steril 95:1787.e1-4. 2011
    ..To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue...
  37. ncbi Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donors
    Angela R Smith
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 15:1086-93. 2009
    ....
  38. ncbi Hematopoietic stem cell transplantation for multiple sclerosis: collaboration of the CIBMTR and EBMT to facilitate international clinical studies
    Marcelo C Pasquini
    Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Biol Blood Marrow Transplant 16:1076-83. 2010
    Clinical investigation of autologous hematopoietic stem cell transplantation (HSCT) as therapy for multiple sclerosis (MS) has been ongoing for over a decade...
  39. ncbi Current international perspectives on hematopoietic stem cell transplantation for inherited metabolic disorders
    Jaap J Boelens
    Department of Pediatrics, Blood and Marrow Transplantation Program, UMC Utrecht, Wilhelmina Children s Hospital, KC 03 063 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Pediatr Clin North Am 57:123-45. 2010
    ..expectations, and the risks and benefits associated with available therapies such as allogeneic hematopoietic stem cell transplantation (HSCT). This review discusses indications for HSCT and outcomes of HSCT for selected IMD...
  40. ncbi Hematopoietic stem cell transplantation for multiple myeloma beyond 2010
    Joan Blade
    Department of Hematology and Bone Marrow Transplant Unit, Institut of Hematology and Oncology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 115:3655-63. 2010
    ..The development of novel reduced-intensity preparative regimens and peri- and posttransplantation strategies aimed at minimizing graft-versus-host disease, and enhancing the graft-versus-myeloma effect are key issues...
  41. ncbi Hematopoietic stem-cell transplantation
    Edward A Copelan
    Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, USA
    N Engl J Med 354:1813-26. 2006
  42. ncbi A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model
    Saki Shimizu
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Blood 115:1534-44. 2010
    ..These results demonstrate that lentiviral vector delivery of shRNA into human HPSCs could stably down-regulate CCR5 in systemic lymphoid organs in vivo...
  43. ncbi New perspectives on the biology of acute GVHD
    S Paczesny
    Department of Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Bone Marrow Transplant 45:1-11. 2010
    ..Herein, we provide a novel perspective on the immunobiology of acute GVHD and briefly discuss some of the outstanding questions and limitations of the model systems...
  44. ncbi The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment
    Bradford K Berges
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA
    Retrovirology 8:65. 2011
    ....
  45. ncbi Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009
    P Ljungman
    Department of Haematology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 45:219-34. 2010
    ..The introduction of alternative therapies, such as imatinib for CML, has challenged well-established indications. An updated report with revised tables and operating definitions is presented...
  46. ncbi Differential anti-inflammatory and anti-fibrotic activity of transplanted mesenchymal vs. hematopoietic stem cells in carbon tetrachloride-induced liver injury in mice
    Sivasami Pulavendran
    Department of Biotechnology Central Leather Research Institute, Adyar Chennai 600020, India
    Int Immunopharmacol 10:513-9. 2010
    ..Our findings suggest that bone marrow MSC are capable of alleviating the immunoreactions leading to the fibrosis in the liver...
  47. ncbi Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice
    Kei Sato
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
    J Virol 84:9546-56. 2010
    ..Taken together, these results provide the evidence indicating that endogenous APOBEC3s are associated with G-to-A mutation of HIV-1 provirus in vivo, which can result in the abrogation of HIV-1 infection...
  48. ncbi Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation
    Yoko Ogawa
    Institute for Advanced Medical Research, and Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 22:S19-27. 2003
    ..To review the condition of dry eye associated with chronic graft-versus-host disease (GVHD)...
  49. ncbi Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis
    Francisco M Marty
    Division of Infectious Diseases, Boston, MA 02115, USA
    Blood 110:490-500. 2007
    ..Whether sirolimus has a similar effect on CMV reactivation after allogeneic hematopoietic stem cell transplantation (HSCT) is not known...
  50. ncbi Searching for alternative hematopoietic stem cell donors for pediatric patients
    V Rocha
    Acute Leukaemia Working Party, Hopital Saint Louis, Paris, France
    Bone Marrow Transplant 41:207-14. 2008
    ....
  51. ncbi C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    Carlos E B Couri
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    JAMA 301:1573-9. 2009
    In 2007, the effects of the autologous nonmyeloablative hematopoietic stem cell transplantation (HSCT) in 15 patients with type 1 diabetes mellitus (DM) were reported...
  52. ncbi Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice
    Bradford K Berges
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virology 373:342-51. 2008
    ....
  53. ncbi High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis
    Arnaud Jaccard
    Department of Hematology, Centre Hospitalier Universitaire, Université et Centre National de la Recherche Scientifique, UMR 6101, Limoges, France
    N Engl J Med 357:1083-93. 2007
    ....
  54. ncbi Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, England, UK
    J Exp Med 206:371-85. 2009
    Animal models of hematopoietic stem cell transplantation have been used to analyze the turnover of bone marrow-derived cells and to demonstrate the critical role of recipient antigen-presenting cells (APC) in graft versus host disease (..
  55. ncbi Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome
    Alain Chapel
    Institut de Radioprotection et de Surete Nucleaire, IRSN DPHD SARAM, Fontenay aux Roses, France
    J Gene Med 5:1028-38. 2003
    ..We investigated the potential of a combined infusion of autologous ex vivo expanded hematopoietic cells with mesenchymal (MSCs) for the treatment of multi-organ failure syndrome following irradiation in a non-human primate model...
  56. ncbi A stem cell molecular signature
    Natalia B Ivanova
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 298:601-4. 2002
    ..Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells...
  57. ncbi Epidemiology of invasive aspergillosis in France: a six-year multicentric survey in the Greater Paris area
    M Cornet
    Service Evaluation Qualité Accréditation et Sécurité Sanitaire, Direction de la Politique Médicale, AP HP, Paris, France
    J Hosp Infect 51:288-96. 2002
    ..4% following kidney transplantation. Incidence in HIV infected patients ranged from 0.02 to 0.13% per annum. This large series confirmed that patients with haematologic disorders and transplantations are the most at risk for IA...
  58. ncbi Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:1390-7. 2006
    ..Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was to study the effect of MSC infusion on graft-versus-host disease (GVHD)...
  59. ncbi Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice
    Fangming Lin
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Mail Code 9063, Dallas, TX 75390 9063, USA
    J Am Soc Nephrol 14:1188-99. 2003
    ..This is the first report to show that HSC can differentiate into renal tubular cells after I/R injury. Because of their availability, HSC may be useful for cell replacement therapy of acute renal failure...
  60. ncbi Autologous stem cell transplantation in progressive multiple sclerosis--an interim analysis of efficacy
    A Fassas
    Department of Hematology, The George Papanicolaou General Hospital, Thessaloniki, Greece
    J Clin Immunol 20:24-30. 2000
    ....
  61. ncbi Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system
    Tobias Alexander
    German Rheumatism Research Center, and Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin, Chariteplatz 1, Berlin, Germany
    Blood 113:214-23. 2009
    Clinical trials have indicated that immunoablation followed by autologous hematopoietic stem cell transplantation (ASCT) has the potential to induce clinical remission in patients with refractory systemic lupus erythematosus (SLE), but ..
  62. ncbi Cord-blood transplants from unrelated donors in patients with Hurler's syndrome
    Susan L Staba
    Pediatric Stem Cell Transplant Program, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 350:1960-9. 2004
    ..We investigated the feasibility of using cord-blood transplants from unrelated donors and a myeloablative preparative regimen that did not involve total-body irradiation in young children with Hurler's syndrome...
  63. ncbi HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model
    Bradford K Berges
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Retrovirology 3:76. 2006
    ..Thus, this model shows considerable promise to study long-term in vivo HIV infection and pathogenesis...
  64. ncbi The use of growth factors in hematopoietic stem cell transplantation
    I Pusic
    Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Pharm Des 14:1950-61. 2008
    ..We also review the data on novel agents for mobilization of stem cells...
  65. ncbi Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide
    L Luznik
    Division of Hematopoiesis, Hematologic Malignancies, and Pediatric Oncology, Johns Hopkins Oncology Center, Baltimore, MD, USA
    Blood 98:3456-64. 2001
    ..These results indicate that stable engraftment of MHC-incompatible cells can be induced after fludarabine-based, nonmyeloablative conditioning and that it serves as a platform for adoptive immunotherapy with donor lymphocyte infusions...
  66. ncbi Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning
    Takahiro Fukuda
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 102:827-33. 2003
    ..of invasive mold infections has increased during the 1990s among patients undergoing allogeneic hematopoietic stem cell transplantation (HCT) after myeloablative conditioning...
  67. ncbi Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial
    Gary P Wang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076, USA
    Blood 115:4356-66. 2010
    ..The approaches to sequencing and bioinformatics analysis reported here should be widely useful in assessing the outcome of gene therapy trials...
  68. ncbi IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
    ....
  69. ncbi Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium
    M von Bonin
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Dresden, Germany
    Bone Marrow Transplant 43:245-51. 2009
    ..In our patient cohort, response to MSC transfusion was lower than in the series reported earlier. However, our experience supports the potential efficacy of MSC in the treatment of steroid-refractory aGVHD...
  70. ncbi Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis
    Eyal Robenshtok
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    J Clin Oncol 25:5471-89. 2007
    ..Many studies have evaluated the role of antifungal prophylaxis in cancer patients, with inconsistent conclusions...
  71. ncbi Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease
    Laura J Johnston
    Stanford University, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 11:47-55. 2005
    ..Given the significant toxicities described, investigation of altered administration of rapamycin and calcineurin inhibitors should be pursued in future cGVHD trials...
  72. ncbi Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    Heather E Fleming
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 2:274-83. 2008
    ..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells...
  73. ncbi Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease
    D R Couriel
    Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Br J Haematol 130:409-17. 2005
    ..Controlled trials comparing this approach with alternative strategies to determine which can best achieve the goal of GVHD-free survival are warranted...
  74. ncbi Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches
    S K Nilsson
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Blood 97:2293-9. 2001
    ..Together, these data strongly support historical evidence of the presence of endosteal hemopoietic stem cell niches...
  75. ncbi Chronic graft-versus-host disease
    Stephanie J Lee
    Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 9:215-33. 2003
    ..It also provides a comprehensive listing of the published clinical trials aimed at prevention and primary treatment of chronic GVHD...
  76. ncbi Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction
    Hiroto Iwasaki
    Stem Cell Translational Research, Kobe Institute of Biomedical Research and Innovation/RIKEN Center for Developmental Biology, Kobe, Japan
    Circulation 113:1311-25. 2006
    ..CONCLUSIONS: Human CD34+ cell transplantation may have significant and dose-dependent potential for vasculogenesis and cardiomyogenesis with functional recovery from MI...
  77. ncbi Hematopoietic stem cell transplantation in patients with severe congenital neutropenia: an analysis of 18 Japanese cases
    Koichi Oshima
    Division of Hematology and Oncology, Saitama Children s Medical Center, Saitama, Japan
    Pediatr Transplant 14:657-63. 2010
    ..6%, respectively. Of our patients, 16 are alive and in complete remission, with a median follow-up of six and a half yr. Our results suggest that HSCT is beneficial for patients with SCN refractory to r-HuG-CSF treatment...
  78. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  79. ncbi Autologous hematopoietic stem cell transplantation for pediatric solid tumors
    Gregory A Hale
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Expert Rev Anticancer Ther 5:835-46. 2005
    ..Autologous hematopoietic stem cell transplantation takes advantage of the steep dose-response relationship observed with many chemotherapeutic ..
  80. ncbi Autologous hematopoietic stem cell transplantation may reverse renal failure in patients with multiple myeloma
    Gaurav C Parikh
    Department of Stem Cell Transplantation and Cellular Therapy, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biol Blood Marrow Transplant 15:812-6. 2009
    ..Many of these patients are considered ineligible for autologous hematopoietic stem cell transplantation (auto-HSCT) because of a high risk of treatment-related toxicity...
  81. ncbi Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation
    Lorenzo Moretta
    Giannina Gaslini Institute, Genova Quarto, Italy
    Blood 117:764-71. 2011
    ..In an allogeneic setting, such as T cell-depleted haploidentical hematopoietic stem cell transplantation, NK cells may express inhibitory killer immunoglobulin-like receptors that are not engaged by any ..
  82. ncbi Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
    S H Appel
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Neurology 71:1326-34. 2008
    ..Amyotrophic lateral sclerosis (ALS), an inexorably progressive motoneuron disease, is accompanied by significantly increased markers of inflammation. These inflammatory constituents could protect, harm, do neither, or do both...
  83. ncbi Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program
    J Morgan
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Med Mycol 43:S49-58. 2005
    ..Our CI figures are lower compared to those of previous reports. The reasons for this are unclear, but may be related to changes in transplantation practices, diagnostic methods, and supportive care...
  84. ncbi HLA-matched sibling hematopoietic stem cell transplantation for fanconi anemia: comparison of irradiation and nonirradiation containing conditioning regimens
    Ricardo Pasquini
    Federal University of Parana, Curitiba, Brazil
    Biol Blood Marrow Transplant 14:1141-7. 2008
    ..As the peak time for developing solid tumors after HCT is 8 to 9 years, longer follow-up is required before definitive statements can be made regarding the impact of nonirradiation regimens on cancer risk...
  85. ncbi Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic cell transplantation
    L E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 44:279-85. 2009
    ..One patient discontinued GH due to slipped capital femoral epiphysis. Preliminary data suggest that 1-year GH treatment may modestly improve growth velocity in children with Hurler syndrome...
  86. ncbi Late effects of cancer and hematopoietic stem-cell transplantation on spouses or partners compared with survivors and survivor-matched controls
    Michelle M Bishop
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
    J Clin Oncol 25:1403-11. 2007
    ..The purpose of this study was to examine the health-related quality of life and post-traumatic growth (PTG) of spouses/partners compared with survivors and controls and to identify factors associated with those outcomes...
  87. ncbi Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
    Benedicte Neven
    Unité d Immuno Hématologie et Rhumatologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 113:4114-24. 2009
    Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for severe combined immunodeficiency (SCID)...
  88. ncbi Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 14:37-44. 2008
  89. ncbi Outcome in six children with mucopolysaccharidosis type IH, Hurler syndrome, after haematopoietic stem cell transplantation (HSCT)
    Gunilla Malm
    Department of Clinical Science, Intervention and Technology, Division of Paediatrics, Karolinska Institutet, Huddinge, Sweden
    Acta Paediatr 97:1108-12. 2008
    ..To follow-up six children with severe mucopolysaccharidosis type IH, Hurler syndrome, who were treated before 24 months of age with haematopoietic stem cell transplantation...
  90. ncbi Consolidation with high-dose chemotherapy and stem cell support for responding patients with metastatic soft tissue sarcomas: prospective, single-institutional phase II study
    B Kasper
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Bone Marrow Transplant 45:1234-8. 2010
    ..The subgroup of patients treated with high-dose chemotherapy gained significant survival benefit. Nevertheless, high-dose chemotherapy as a possible consolidation strategy remains highly investigational...
  91. ncbi Unrelated donor and HLA-identical sibling haematopoietic stem cell transplantation cure chronic granulomatous disease with good long-term outcome and growth
    Elena Soncini
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Br J Haematol 145:73-83. 2009
    ..Transplant-associated complications were restricted to those with pre-existing infection or inflammation, supporting the argument for early HSCT for more CGD patients with a well matched donor...
  92. ncbi Hematopoietic stem cells convert into liver cells within days without fusion
    Yoon-Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Cell Biol 6:532-9. 2004
    ..Notably, liver function was restored 2-7 d after transplantation. We conclude that HSCs contribute to the regeneration of injured liver by converting into functional hepatocytes without fusion...
  93. ncbi Resistance of mature T cells to oncogene transformation
    Sebastian Newrzela
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt, Germany
    Blood 112:2278-86. 2008
    ..Thus, our data provide direct evidence that mature T cells are less prone to transformation than hematopoietic progenitor cells...
  94. ncbi A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation
    Fabio Ciceri
    Hematology and BMT Unit, San Raffaele Scientific Institute, Milano, Italy
    Blood 112:3574-81. 2008
    Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is an alternative treatment to patients with high-risk acute leukemia lacking a human leukocyte antigen-matched donor...
  95. ncbi Trends in haematopoietic cell transplantation for inborn errors of metabolism
    Jaap Jan Boelens
    Department of Immunology BMT, UMC Utrecht Wilhelmina Children s Hospital, Utrecht, The Netherlands
    J Inherit Metab Dis 29:413-20. 2006
    ..A good functioning worldwide registry would be necessary to measure the effects of the procedures performed in more detail...
  96. ncbi Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation
    Ann Mullally
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 109:1355-62. 2007
    ..Clearly, this more diverse view of the genome has significant implications for allogeneic hematopoietic stem cell transplantation, not least in the generation of transplant antigens but also in terms of individual ..
  97. ncbi Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD
    Daniel R Couriel
    Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 423, Houston, TX 77030, USA
    Blood 107:3074-80. 2006
    Chronic graft-versus-host disease (GVHD) is a major limitation of successful allogeneic hematopoietic stem cell transplantation (HSCT)...
  98. ncbi Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation
    Satoshi Yoshihara
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Biol Blood Marrow Transplant 13:749-59. 2007
    Pulmonary dysfunction is a significant complication following allogeneic hematopoietic stem cell transplantation (HSCT), and is associated with significant morbidity and mortality...
  99. ncbi Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study
    A Fassas
    George Papanicolaou General Hospital, Dpt Hematology, 57010 Thessaloniki, Greece
    J Neurol 249:1088-97. 2002
    Phase I/II studies of autologous hematopoietic stem cell transplantation (HSCT) for multiple sclerosis ( MS) were initiated, based on results of experimental transplantation in animal models of multiple sclerosis and clinical ..
  100. ncbi Predictive factors for outcomes after reduced intensity conditioning hematopoietic stem cell transplantation for hematological malignancies: a 10-year retrospective analysis from the Société Française de Greffe de Moelle et de Thérapie Cellulaire
    Mauricette Michallet
    Service d Hematologie, Hopital Edouard Herriot, Lyon, France
    Exp Hematol 36:535-44. 2008
    ..and transplantation variables on outcomes of 1108 patients who have undergone allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning (RIC HSCT) for hematological malignancies and were reported ..
  101. ncbi Role of nonmyeloablative allogeneic stem-cell transplantation after failure of autologous transplantation in patients with lymphoproliferative malignancies
    Katharine Branson
    CR (UK) Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom
    J Clin Oncol 20:4022-31. 2002
    ..The low incidence of early GVHD enabled the subsequent administration of DLI to improve further clinical responses in this poor-risk group of lymphoma and myeloma patients...

Research Grants96

  1. Allogeneic Stem Cell Transplants for HPV+Cervical Cancer
    Alexander Fefer; Fiscal Year: 2003
    ..allogeneic adoptive T-cell immunotherapy in the context of non-myeloablative allogeneic hematopoietic stem cell transplantation (NST) for the treatment of non-hematologic malignancies...
  2. Post-transplant vaccines to enhance graft-versus-leukemia responses
    CATHERINE JU YING WU; Fiscal Year: 2010
    A curative graft-versus-leukemia (GvL) response following allogeneic hematopoietic stem cell transplantation (HSCT) results from the: (1) restoration of normal immunity, thus overcoming leukemia- or treatment-induced immune ..
  3. Training Patients and Partners for HSCT: A Novel Coping Skills Intervention
    Catalina Lawsin; Fiscal Year: 2007
    b>Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment of hematological malignancies and related disorders with more than 40,000 transplants conducted each year...
  4. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2011
    ..to inhibit unwanted immune responses that occur during autoimmune disease or as a consequence of hematopoietic stem cell transplantation (HSCT) or tissue transplant rejection reactions...
  5. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    KATHERINE PONDER; Fiscal Year: 2009
    ..b>Hematopoietic stem cell transplantation can reduce some manifestations, but has a 15% mortality rate, costs $130,000, and requires a ..
  6. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2010
    ..b>Hematopoietic stem cell transplantation can reduce some manifestations, but has a 15% mortality rate, costs $130,000, and requires a ..
  7. Imaging Infused CD19 Specific T Cells in the Tumor
    LAURENCE COOPER; Fiscal Year: 2007
    ..This project develops the tools to non-invasively measure the distribution and activation status of infused tumor-specific T cells. This will help investigators gauge the efficacy of T-cell immunotherapies. ..
  8. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2010
    ..LAY SUMMARY: We will infuse CD19-specific T cells after transplantation to improve survival for patients with acute lymphoblastic leukemia. ..
  9. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2010
    ..We believe that the information we derive can be directly translated to improve hematopoietic stem cell transplantation.Eicosanoids are physiological lipids that include prostaglandins, prostacyclins, thromboxanes, ..
  10. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..These neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  11. Population Pharmacokinetics/Pharmacodynamics in Nonablative Stem Cell Recipients
    Jeannine McCune; Fiscal Year: 2009
    Nonablative hematopoietic stem cell transplantation (HCT) with an unrelated donor graft has greatly expanded the number of patients suffering from hematologic diseases and malignancies who can be cured by HCT...
  12. Population Pharmacokinetics/Pharmacodynamics in Nonablative Stem Cell Recipients
    Jeannine S McCune; Fiscal Year: 2010
    Nonablative hematopoietic stem cell transplantation (HCT) with an unrelated donor graft has greatly expanded the number of patients suffering from hematologic diseases and malignancies who can be cured by HCT...
  13. Population Pharmacokinetics/Pharmacodynamics in Nonablative Stem Cell Recipients
    Jeannine McCune; Fiscal Year: 2009
    PROJECT SUMMARY Nonablative hematopoietic stem cell transplantation (HCT) with an unrelated donor graft has greatly expanded the number of patients suffering from hematologic diseases and malignancies who can be cured by HCT...
  14. Characterization of A Novel 65kDa E-selectin Ligand on G-CSF Mobilized Leukocytes
    Robert Sackstein; Fiscal Year: 2007
    ..blood (MPB) has replaced traditional bone marrow harvest as the preferred source of cells for hematopoietic stem cell transplantation. Though generally considered to be a safer alternative to harvest, there are increasing ..
  15. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2003
    DESCRIPTION: (Applicant's Abstract) Allogeneic hematopoietic stem cell transplantation (HSCT) is curative therapy for hematologic malignancies, aplastic anemia and a variety of genetic conditions; however, significant treatment-related ..
  16. IN UTERO STEM CELL TRANSPLANTATION
    Esmail Zanjani; Fiscal Year: 2009
    In utero hematopoietic stem cell transplantation (IUSCT) is a promising therapeutic approach for many genetic disorders...
  17. Krabbe disease: Combined therapies for the central and peripheral nervous systems
    David A Wenger; Fiscal Year: 2010
    ..The only treatment currently available for some patients is hematopoietic stem cell transplantation (HSCT)...
  18. IN UTERO STEM CELL TRANSPLANTATION
    Esmail D Zanjani; Fiscal Year: 2010
    In utero hematopoietic stem cell transplantation (IUSCT) is a promising therapeutic approach for many genetic disorders...
  19. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    Over the past decade, the use of immune deficient mice as recipients for human hematopoietic stem cell transplantation has dramatically improved stem cell research...
  20. Optimizing Nonmyeloablative Stem Cell Transplantation
    Marco Mielcarek; Fiscal Year: 2007
    ..have been impressed by the toxicities associated with conditioning regimens used for conventional hematopoietic stem cell transplantation (HSCT)...
  21. IL-12-Faciliated Hematopoietic Recovery Following Myeloablative Therapy
    Dan Douer; Fiscal Year: 2007
    Intensive myeloablative cytotoxic treatment followed by autologous hematopoietic stem cell transplantation (HSCT) is frequently used in clinical practice to cure or improve survival of hematological malignancies...
  22. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2007
    ..research interest is in the impact of killer immunoglobulin-like receptors (KIR) on allogeneic hematopoietic stem cell transplantation. AIIogeneic hematopoietic stem cell transplantation (AHSCT) is a valuable therapy for acute ..
  23. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence...
  24. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    KATHERINE PONDER; Fiscal Year: 2007
    ..b>Hematopoietic stem cell transplantation can reduce certain manifestations, but has a 20% mortality rate...
  25. Strategy to Cure Type 1 Diabetes
    Zhiguang Guo; Fiscal Year: 2003
    Recent developments in hematopoietic stem cell transplantation provide a new therapeutic opportunity for treating type 1 diabetes...
  26. IMMUNOGENETICS OF MARROW ALLOGRAFTING
    John Hansen; Fiscal Year: 2006
    b>Hematopoietic stem cell transplantation (HSCT) has become life saving therapy for patients with various congenital, acquired and malignant diseases of the immune and hematopoietic systems...
  27. Optimizing Immunotherapy for Neuroblastoma after BMT
    Bryon Johnson; Fiscal Year: 2009
    ..For advanced disease, autologous hematopoietic stem cell transplantation (HSCT) has resulted in significantly better event-free survival as compared to maintenance ..
  28. graft-verus-host disease and graft-versus-leukemia
    THEA FRIEDMAN; Fiscal Year: 2006
    Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for a variety of hematological malignancies...
  29. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2010
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for ..