cell transplantation

Summary

Summary: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.

Top Publications

  1. ncbi Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
  2. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
  3. ncbi Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
  4. ncbi Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Nucl Med 51:7-15. 2010
  5. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
  6. ncbi Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a cotransplantation approach with fetal ventral mesencephalic cells
    A K Agrawal
    Developmental Toxicology Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226 001, India
    Neurobiol Dis 16:516-26. 2004
  7. ncbi Osteogenic potential of cultured human periosteum-derived cells - a pilot study of human cell transplantation into a rat calvarial defect model
    Yoshiro Sakata
    Department of Oral and Maxillofacial Reconstructive Surgery (Head: Prof. Dr. Toshio Sugahara, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Craniomaxillofac Surg 34:461-5. 2006
  8. ncbi Melanocyte-keratinocyte cell transplantation for stable vitiligo
    Sanjeev V Mulekar
    Noble Clinic, Pune, India
    Int J Dermatol 42:132-6. 2003
  9. ncbi Beating and arrested intramyocardial injections are associated with significant mechanical loss: implications for cardiac cell transplantation
    Wes Hudson
    Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Surg Res 142:263-7. 2007
  10. ncbi Hepatitis C virus replication in mice with chimeric human livers
    D F Mercer
    Surgical-Medical Research Institute, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Nat Med 7:927-33. 2001

Research Grants

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
  2. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2010
  3. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2010
  4. Post-transplant vaccines to enhance graft-versus-leukemia responses
    CATHERINE JU YING WU; Fiscal Year: 2010
  5. Genes, Environment & Neural Stem Cell Transplantation in the Gut
    PANKAJ PASRICHA; Fiscal Year: 2009
  6. Genes, Environment & Neural Stem Cell Transplantation in the Gut
    Pankaj J Pasricha; Fiscal Year: 2010
  7. Training Patients and Partners for HSCT: A Novel Coping Skills Intervention
    Catalina Lawsin; Fiscal Year: 2007
  8. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2009
  9. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2010
  10. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2011

Detail Information

Publications255 found, 100 shown here

  1. ncbi Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
    ..For this reason, we analyzed 10 patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI...
  2. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  3. ncbi Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
    ..Thus, these studies establish that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration...
  4. ncbi Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Nucl Med 51:7-15. 2010
    ..Nonetheless, clinical improvement was significant only in younger (age < or = 60 y) transplant recipients, as indicated by a reduction in Unified Parkinson's Disease Rating Scale (UPDRS) motor scores...
  5. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  6. ncbi Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a cotransplantation approach with fetal ventral mesencephalic cells
    A K Agrawal
    Developmental Toxicology Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226 001, India
    Neurobiol Dis 16:516-26. 2004
    ..The results suggest that cotransplantation of OECs and VMC may be a better approach for functional restoration in 6-OHDA-induced rat model of Parkinson's disease...
  7. ncbi Osteogenic potential of cultured human periosteum-derived cells - a pilot study of human cell transplantation into a rat calvarial defect model
    Yoshiro Sakata
    Department of Oral and Maxillofacial Reconstructive Surgery (Head: Prof. Dr. Toshio Sugahara, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Craniomaxillofac Surg 34:461-5. 2006
    ..By 5 weeks, bone growth was observed and new calcification was detected in the defect. CONCLUSION: Cultured human periosteum-derived cells showed osteogenic potential in a xenogeneic graft model using rat calvarial defects...
  8. ncbi Melanocyte-keratinocyte cell transplantation for stable vitiligo
    Sanjeev V Mulekar
    Noble Clinic, Pune, India
    Int J Dermatol 42:132-6. 2003
    ..Vitiligo is a common disorder with a worldwide prevalence of 1-2%. In India the psychological and social impact of the disease is significant and is detrimental to patients...
  9. ncbi Beating and arrested intramyocardial injections are associated with significant mechanical loss: implications for cardiac cell transplantation
    Wes Hudson
    Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Surg Res 142:263-7. 2007
    ..Mechanical and biological mechanisms may account for observed donor cell loss. This study examines acute mechanical loss during intramyocardial injections in beating and arrested hearts...
  10. ncbi Hepatitis C virus replication in mice with chimeric human livers
    D F Mercer
    Surgical-Medical Research Institute, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Nat Med 7:927-33. 2001
    ..These chimeric mice represent the first murine model suitable for studying the human hepatitis C virus in vivo...
  11. ncbi Creation of a prevascularized site for cell transplantation in rats
    Philipp Stiegler
    Department of Surgery, Division of Transplantation Surgery, Medical University Graz, Graz, Austria
    Xenotransplantation 17:379-90. 2010
    ..The aim of this study was to create a prevascularized site for cell transplantation in rats and test its effectiveness with microencapsulated HEK293 cells.
  12. ncbi Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation
    Ian Y Chen
    Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging Biol 11:178-87. 2009
    ....
  13. ncbi Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow
    Atsushi Nagai
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    PLoS ONE 2:e1272. 2007
    ....
  14. ncbi Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
  15. ncbi Transplanted adult bone marrow cells repair myocardial infarcts in mice
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 938:221-9; discussion 229-30. 2001
    ..These in vivo findings demonstrate the capacity of highly enriched Lin- c-kit+ adult bone marrow cells to acutely regenerate functional myocardium within an infarcted region...
  16. ncbi Massive mechanical loss of microspheres with direct intramyocardial injection in the beating heart: implications for cellular cardiomyoplasty
    Carolyn J Teng
    Division of Cardiac Surgery, McGill University, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 132:628-32. 2006
    ....
  17. ncbi Tolerogenic functions of human leukocyte antigen G: from pregnancy to organ and cell transplantation
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Transplantation 84:S21-5. 2007
    ..In this paper, we focus our attention on the relevance of HLA-G in transplantation in the light of recent data associating regulatory T cells and HLA-G, and which provide evidence of the role of HLA-G in improving graft acceptance...
  18. ncbi Protein C and procollagen III peptide levels in patients with hepatic dysfunction after allogeneic hematopoietic stem cell transplantation
    M Pihusch
    Abteilung fuer Haematologie und Internistische Onkologie, Klinikum der Universitaet Regensburg, Regensburg, Germany
    Bone Marrow Transplant 36:631-7. 2005
    Veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (HSCT) and is associated with a high mortality...
  19. ncbi One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects
    Jochen Meyburg
    Department of General Pediatrics, University Children s Hospital, Heidelberg, Germany
    Transplantation 87:636-41. 2009
    ..They are promising target diseases for liver cell transplantation (LCT), which may be a less invasive alternative or supplementation to orthotopic liver transplantation.
  20. ncbi Cell transplantation, myelin repair, and multiple sclerosis
    Christopher Halfpenny
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
    Lancet Neurol 1:31-40. 2002
    ..We attempt to highlight those areas where difficulties have yet to be resolved, and draw on various experimental findings to speculate on how remyelinating therapies are likely to develop in the foreseeable future...
  21. ncbi Liver and liver cell transplantation for glycogen storage disease type IA
    M Muraca
    Laboratory Medicine, Department of Laboratories, Ospedale Pediatrico Bambino Gesu, Roma, Italy
    Acta Gastroenterol Belg 68:469-72. 2005
    ..Finally, hepatic adenomas need careful monitoring because of the possible risk of malignant transformation...
  22. ncbi Principles of hepatocyte repopulation
    Ezio Laconi
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, c o Oncology Hospital A Businco, Via Jenner, 09125, Cagliari, Italy
    Semin Cell Dev Biol 13:433-8. 2002
    ..To this end, a relative growth advantage must be present or is to be imposed on transplanted hepatocytes versus resident cells. Possible strategies are presented and discussed...
  23. ncbi Liver repopulation after hepatocellular transplantation: integration and interaction of transplanted hepatocytes in the host
    Sarah Koenig
    Department of General Surgery, Georg August University Goettingen, 37099 Germany
    Cell Transplant 14:31-40. 2005
    ..FACS analysis reveals an accurate method to determine quantitatively the extent of liver repopulation...
  24. ncbi Differentiation "in vitro" of primary and immortalized porcine mesenchymal stem cells into cardiomyocytes for cell transplantation
    I Moscoso
    Unidad de Investigacion, Complejo Hospitalario Universitario, Juan Canalejo, , Murcia, Spain
    Transplant Proc 37:481-2. 2005
    b>Cell transplantation to regenerate injured tissues is a promising new treatment for patients suffering several diseases...
  25. ncbi Transplanted primary neonatal myoblasts can give rise to functional satellite cells as identified using the Myf5nlacZl+ mouse
    L Heslop
    Muscle Cell Biology Group, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Gene Ther 8:778-83. 2001
    ..These observations demonstrate that cell transplantation not only results in the incorporation of donor nuclei into the host muscle syncytia, but also that the ..
  26. ncbi Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    BMC Med 9:50. 2011
    Clinical trials aiming to assess the safety and efficacy of fetal cell transplantation in Parkinson's disease rely on the hypothesis that the grafted tissue will survive and grow, restore striatal dopaminergic neurotransmission, improve ..
  27. ncbi Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation
    P Buchwald
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Pharmazie 65:421-8. 2010
    ....
  28. ncbi Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair
    Yuben Moodley
    F R A C P School of Medicine and Pharmacology, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
    Am J Respir Crit Care Med 182:643-51. 2010
    ..Cellular therapies that could restore pneumocytes and reduce inflammation and fibrosis would be a major advance in management...
  29. ncbi Porcine endogenous retrovirus (PERV) was not transmitted from transplanted porcine endothelial cells to baboons in vivo
    U Martin
    Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Germany
    Transpl Int 11:247-51. 1998
    ..in vivo transfer of PERV after xenotransplantation was investigated in an experimental pig-to-baboon cell transplantation model...
  30. ncbi Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results
    J S Fink
    Genzyme Corporation, Cambridge, MA 02139, USA
    Cell Transplant 9:273-8. 2000
    ....
  31. ncbi Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium?
    J Leor
    Cardiac Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Circulation 102:III56-61. 2000
    ..The heart is therefore an attractive target for tissue engineering to replace infarcted myocardium and enhance cardiac function. We tested the feasibility of bioengineering cardiac tissue within novel 3-dimensional (3D) scaffolds...
  32. ncbi Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: a double blind video-based analysis
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Mov Disord 24:336-43. 2009
    ..Off-medication dyskinesias are common following transplantation and may represent a prolonged form of diphasic dyskinesias...
  33. ncbi Delivery of proteins and peptides into live cells by means of protein transduction domains: potential application to organ and cell transplantation
    Ricardo L Pastori
    Diabetes Research Institute, University of Miami School of Medicine, Miami, FL 33136, USA
    Transplantation 77:1627-31. 2004
  34. ncbi A novel cell transplantation protocol and its application to an ALS mouse model
    Eri Morita
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    Exp Neurol 213:431-8. 2008
    ..The extensive distribution of motor neurons is an obstacle to applying cell transplantation therapy for the treatment of ALS...
  35. ncbi Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial
    A Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
    Brain 131:2376-86. 2008
    Olfactory ensheathing cells show promise in preclinical animal models as a cell transplantation therapy for repair of the injured spinal cord...
  36. ncbi Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos
    C Dirk Keene
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Transplant 12:201-13. 2003
    ....
  37. ncbi Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
    Hyun Jai Cho
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Exp Med 204:3257-69. 2007
    ..effects have emerged as important mechanisms mediating therapeutic effects of stem or progenitor cell transplantation. Here, we investigated the expression patterns and sources of humoral factors and their regional and ..
  38. ncbi Percutaneous transvenous cellular cardiomyoplasty. A novel nonsurgical approach for myocardial cell transplantation
    Craig A Thompson
    Cardiovascular Division, Knight Center for Cardiac Catheterization and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Blake 950, Boston, MA 02114, USA
    J Am Coll Cardiol 41:1964-71. 2003
    ..The study evaluated a nonsurgical means of intramyocardial cell introduction using the coronary venous system for direct myocardial access and cell delivery...
  39. ncbi Diabetic heart dysfunction: is cell transplantation a potential therapy?
    Joel Price
    Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Toronto General Hospital, Toronto, Canada
    Heart Fail Rev 8:213-9. 2003
    ..The increasing prevalence of obesity and sedentary lifestyle in Western society are leading to an increase in the prevalence in diabetes. As such diabetes is an increasing cause of cardiovascular disease...
  40. ncbi Mesothelial cell transplantation in models of acute inflammation and chronic peritoneal dialysis
    Liesbeth H P Hekking
    Department of Molecular Cell Biology, VU University Medical Center, Amsterdam, The Netherlands
    Perit Dial Int 23:323-30. 2003
    ..In the present study, we evaluated the possibility of using autologous genetically modified MCs for transplantation after the induction of peritoneal injury by acute inflammatory mediators or chronic instillation of PD fluid...
  41. ncbi Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms
    Daniel Skuk
    Unité de Recherche en Génétique Humaine, Centre de Recherche du Centre Hospitalier de l Universite Laval, CHUL du CHUQ, Ste Foy, Quebec, Canada
    J Neuropathol Exp Neurol 62:951-67. 2003
    ..As a result of our findings, many concepts concerning the early donor cell death following myoblast transplantation must be reconsidered...
  42. ncbi Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    E Lagasse
    StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA
    Nat Med 6:1229-34. 2000
    ....
  43. ncbi Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation
    Francis D Pagani
    Section of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Coll Cardiol 41:879-88. 2003
    ..We report histological analysis of hearts from patients with end-stage heart disease who were transplanted with autologous skeletal myoblasts concurrent with left ventricular assist device (LVAD) implantation...
  44. ncbi Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice
    M Zhao
    Department of Diabetes, Endocrinology and Internal Medicine, King's College GKT Medical School, Bessemer Road, London SE5 9PJ, UK
    Diabetologia 48:2051-61. 2005
    ..CONCLUSIONS/INTERPRETATION: Human pancreatic cells are a potential source of new glucose-responsive insulin-producing cells that may be developed further for clinical use...
  45. ncbi Injectable biopolymers enhance angiogenesis after myocardial infarction
    Ngan F Huang
    UCSF/UCB Joint Bioengineering Graduate Group, University of California Berkeley, Berkeley, California, USA
    Tissue Eng 11:1860-6. 2005
    ..The results of this study highlight the potential clinical benefit of these biopolymers as injectable scaffolds or cell delivery vehicles to the infarct zone after infarction...
  46. ncbi Schwann cell transplantation for repair of the adult spinal cord
    Martin Oudega
    The Miami Project to Cure Paralysis and the Department of Neurological Surgery, University of Miami School of Medicine, Miami, Florida, USA
    J Neurotrauma 23:453-67. 2006
    ..Clearly, Schwann cells have great potential for repair of the injured spinal cord, but they need to be combined with other interventions to maximize axonal regeneration and functional recovery...
  47. ncbi Continuous release of endostatin from microencapsulated engineered cells for tumor therapy
    T Joki
    Brain Tumor Laboratory, Department of Neurosurgery, Department of Surgery, Brigham Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nat Biotechnol 19:35-9. 2001
    ..Encapsulated endostatin-secreting cells are effective for the treatment of human glioblastoma xenografts. Continuous local delivery of endostatin may offer an effective therapeutic approach to the treatment of a variety of tumor types...
  48. ncbi Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 26:129-40. 2006
    ..These results indicate that human NSC, genetically transduced with TH and GTPCH1 genes, have great potential in clinical utility for cell replacement therapy in patients suffering from Parkinson disease...
  49. ncbi Paracrine effects of cell transplantation: strategies to augment the efficacy of cell therapies
    Andrew S Cheng
    Division of Cardiovascular Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Semin Thorac Cardiovasc Surg 20:94-101. 2008
    Within the last few years, it has become evident that the beneficial effect of cell transplantation on ventricular function and myocardial perfusion is in large part mediated through paracrine effects on the host myocardium...
  50. ncbi The role of stem cells in skeletal and cardiac muscle repair
    Miranda D Grounds
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia
    J Histochem Cytochem 50:589-610. 2002
    ..For heart muscle, experiments showing the participation of bone marrow-derived stem cells and endothelial cells in the repair of damaged cardiac muscle are encouraging...
  51. ncbi Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells
    Terrence M Yau
    Division of Cardiovascular Surgery, Department of Clinical Biochemistry, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 75:169-76; discussion 176-7. 2003
    BACKGROUND: Cell transplantation may restore function after myocardial infarction, but the optimal cell type remains controversial...
  52. ncbi In vitro study of alginate-chitosan microcapsules: an alternative to liver cell transplants for the treatment of liver failure
    Tasima Haque
    Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, Canada H3A 2B4
    Biotechnol Lett 27:317-22. 2005
    The application of alginate-chitosan (AC) microcapsules to liver cell transplantation has not been previously investigated...
  53. ncbi Mediators involved in the immunomodulatory effects of apoptotic cells
    Philippe Saas
    INSERM U645, University of Besancon, Etablissement Français du Sang Bourgogne Franche Comté, 1 boulevard A Fleming, F 25020 Besançon, France
    Transplantation 84:S31-4. 2007
    ..e., TGF-beta) or immunomodulatory cells ("alternatively-activated" macrophages, certain dendritic cell subsets, or regulatory T cells) in a physiological manner by using apoptotic cell infusion can be a promising way to induce tolerance...
  54. ncbi Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells
    Dilek Colak
    Helmhotz Center Munich, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 28:434-46. 2008
    ..Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis...
  55. ncbi Cell transplantation in Parkinson's disease: how can we make it work?
    Christian Winkler
    Department of Neurology, Hannover Medical School, 30625 Hannover, Germany
    Trends Neurosci 28:86-92. 2005
    ....
  56. ncbi Neural cell transplantation effects on sciatic nerve regeneration after a standardized crush injury in the rat
    A L Luis
    Centro de Estudos de Ciência Animal CECA, Instituto de Ciências e Tecnologias Agrárias e Agro Alimentares ICETA, Universidade do Porto, Campus Agrário de Vairão, Rua P Armando Quintas, Vairao, Portugal
    Microsurgery 28:458-70. 2008
    ..To set up an appropriate experimental model for investigating the effects of neural cell transplantation, we have recently described the sequence of functional and morphologic changes occurring after a ..
  57. ncbi Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: an interim report on safety considerations and possible outcomes
    Hooshang Saberi
    Department of Neurosurgery and Iranian Tissue Bank, Tehran University of Medical Sciences Tehran University, Tehran, Iran
    Neurosci Lett 443:46-50. 2008
    Several experimental studies have introduced Schwann cell transplantation as a means of recovery in animal models of spinal cord injury (SCI)...
  58. ncbi Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study
    Susanne Binder
    Department of Ophthalmology, The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Lasersurgery, Rudolf Foundation Clinic, Vienna, Austria
    Am J Ophthalmol 133:215-25. 2002
    ....
  59. ncbi Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord
    Jike Lu
    Neural Injury Research Unit, School of Anatomy, University of New South Wales, Sydney Australia
    Brain 125:14-21. 2002
    ..Olfactory ensheathing cells are accessible and available in the human nose; the present study further supports clinical use of these cells in repairing the human spinal cord via autologous transplantation...
  60. ncbi Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes
    Tuan Huy Nguyen
    Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland
    J Hepatol 43:1031-7. 2005
    ..CONCLUSIONS: Lentiviral vectors represent tools of choice for immortalization of non-dividing primary cells, and lentivirally immortalized human hepatocytes are promising reagents for cell-based therapy of acute liver failure...
  61. ncbi Cell transplantation for stroke
    Sean I Savitz
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 52:266-75. 2002
    b>Cell transplantation has emerged as an experimental approach to restore brain function after stroke...
  62. ncbi Growing new endocrine pancreas in situ
    Marc R Hammerman
    Renal Division, Box 8126, Department of Medicine, and Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Clin Exp Nephrol 10:1-7. 2006
    ..Here we review studies exploring the potential for pancreatic organogenesis post-transplantation of embryonic primordia as a therapy for type 1 diabetes...
  63. ncbi Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
    ..These results provide new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal...
  64. ncbi Species variability in the differentiation potential of in vitro-expanded articular chondrocytes restricts predictive studies on cartilage repair using animal models
    Paolo Giannoni
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Tissue Eng 11:237-48. 2005
    ..In addition, for tissue-engineering purposes, the number of cell duplications must be, for each species, carefully monitored to remain in the range of amplification allowing redifferentiation and chondrogenesis...
  65. ncbi Differentiation of mouse embryonic stem cells into endothelial cells: genetic selection and potential use in vivo
    Clotilde Gimond
    CNRS UMR 6543, Institute of Signalling Development Biology and Cancer, Nice, France
    Methods Mol Biol 330:303-29. 2006
    ....
  66. ncbi Astrocytes promote neurogenesis from oligodendrocyte precursor cells
    P M Gaughwin
    Department of Clinical Neurosciences and Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:945-56. 2006
    ..The present findings show that hippocampal, astrocyte-derived signals can induce the neuronal differentiation of OPCs through a Noggin-independent mechanism...
  67. ncbi Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, IL 60612, USA
    Exp Cell Res 312:2454-64. 2006
    ..These findings may have significant potential to advance stem-cell-based therapeutics...
  68. ncbi Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway
    Masanori Terai
    Department of Reproductive Biology and Pathology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan
    Mol Biol Cell 16:1491-9. 2005
    ..UCBTERTs provide a powerful model for further study of cellular senescence and for future application to cell-based therapy by using umbilical cord blood cells...
  69. ncbi A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, MD 20892, USA
    J Clin Invest 114:1704-13. 2004
    ..This study demonstrates that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-beta/Smad2 pathway and cell cycle progression...
  70. ncbi Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
    Tamir Ben-Hur
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    Stem Cells 22:1246-55. 2004
    ..Our observations encourage further developments for the potential use of hESCs in the treatment of Parkinson's disease...
  71. ncbi Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration
    Theo Kofidis
    Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, CA 94305, USA
    Stem Cells 22:1239-45. 2004
    ..01). IGF did not affect the cellular response to the donor cells or tumorigenicity. IGF-1 promotes expression of cardiomyocyte phenotype in ESCs in vivo. It should be considered as an adjuvant to cell transfer for myocardial restoration...
  72. ncbi Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture
    Thomas C Schulz
    BresaGen Inc, 111 Riverbend Rd, Athens, Georgia, 30605, USA
    Stem Cells 22:1218-38. 2004
    ..This work suggests that hESCs can differentiate in simple serum-free suspension cultures to produce the large number of cells required for transplantation studies...
  73. ncbi In vitro cultured islet-derived progenitor cells of human origin express human albumin in severe combined immunodeficiency mouse liver in vivo
    Marc Alexander von Mach
    II Medical Department, University of Mainz, Mainz, Germany
    Stem Cells 22:1134-41. 2004
    ..The mechanism underlying this phenomenon seems to be transdifferentiation, because human and mouse albumin were found to be expressed in distinct cells in the host liver...
  74. ncbi Effects of type IV collagen and laminin on the cryopreservation of human embryonic stem cells
    Sun Jong Kim
    Division of Stem Cell Biology, Medical Research Center, MizMedi Hospital, Kangseo-ku, Seoul 157-280, Korea
    Stem Cells 22:950-61. 2004
    ..This new slow freezing method by ECM treatment is a reliable and effective cryopreservation method for pluripotent hES cells...
  75. ncbi Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion
    Yoshitada Tanabe
    Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Faculty of Medicine, Tottori University, Japan
    Biochem Biophys Res Commun 324:711-8. 2004
    ..These results suggest that CD34+UCB cells are rich fractions in hepatic progenitor cells, and that transdifferentiation from UCB cells into hepatocytes as well as cell fusion simultaneously occur in this situation...
  76. ncbi Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration
    M D Schuster
    Department of Surgery and Medicine, Columbia University, New York, New York 10032, USA
    Am J Physiol Heart Circ Physiol 287:H525-32. 2004
    ..Our results suggest that agents that increase myocardial homing of bone marrow angioblasts could effectively induce endogenous cardiomyocytes to enter the cell cycle and improve functional cardiac recovery...
  77. ncbi Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury
    Asha Bakshi
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Eur J Neurosci 23:2119-34. 2006
    ..2 cells. Our results suggest that transplantation of GDNF-expressing NPCs in the acute post-traumatic period promotes graft survival, migration, neuronal differentiation and improves cognitive outcome following traumatic brain injury...
  78. ncbi Paraxial mesodermal progenitors derived from mouse embryonic stem cells contribute to muscle regeneration via differentiation into muscle satellite cells
    Hidetoshi Sakurai
    Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Stem Cells 26:1865-73. 2008
    ..This knowledge could be used to form the foundation of the development of stem cell therapies to repair diseased and damaged muscles...
  79. ncbi Inhibition of human dental pulp stem cell differentiation by Notch signaling
    C Zhang
    Department of Special Dental Service, School and Hospital of Stomatology, Peking University, Beijing, China
    J Dent Res 87:250-5. 2008
    ..Taken together, our results demonstrate that Notch signaling can inhibit the odontoblastic differentiation of DPSCs...
  80. ncbi Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas
    Muriel Castaing
    , , France
    Dev Dyn 234:339-45. 2005
    ..This proliferative capacity of early endocrine progenitor cells in embryonic human pancreas may hold promise for obtaining human beta-cell expansion...
  81. ncbi Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction
    Gregory S Jack
    Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Urol 174:2041-5. 2005
    ..PLA cells may provide a feasible and cost-effective cell source for urinary tract reconstruction...
  82. ncbi Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach
    A Fodor
    The Institute of Endocrinology, Diabetes and Metabolism, Rambam Medical Center, P O Box 9602, Haifa, 31096, Israel
    Diabetologia 50:121-30. 2007
    ..We examined a clinical model of ex vivo transdifferentiation of primary adult hepatocytes to insulin-secreting cells for the treatment of type 1 diabetes...
  83. ncbi Proliferation and differentiation of transplantable rabbit epithelial sheets engineered with or without an amniotic membrane carrier
    Kazunari Higa
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Invest Ophthalmol Vis Sci 48:597-604. 2007
    ....
  84. ncbi Generation of cerebellar neuron precursors from embryonic stem cells
    Hong Lin Su
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo, Kobe 650 0047, Japan
    Dev Biol 290:287-96. 2006
    ..This is the first report of in vitro recapitulation of early differentiation of cerebellar neurons by using the ES cell system...
  85. ncbi Long-term self-renewal of postnatal muscle-derived stem cells
    B M Deasy
    Department of Bioengineering, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Biol Cell 16:3323-33. 2005
    ....
  86. ncbi Adipocyte differentiation of human marrow mesenchymal stem cells reduces the supporting capacity for hematopoietic progenitors but not for severe combined immunodeficiency repopulating cells
    Nobuhiko Ookura
    Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Int J Mol Med 19:387-92. 2007
    ..These findings show that differentiation of MSCs into adipocytes is accompanied by the loss of capacity to support mature HPCs, but not transplantable SCID-repopulating cells...
  87. ncbi GDNF delivery using human neural progenitor cells in a rat model of ALS
    Sandra M Klein
    Waisman Center and Department of Anatomy, University of Wisconsin, Madison, WI 53703, USA
    Hum Gene Ther 16:509-21. 2005
    ..As such, they provide an interesting source of cells for both glial replacement and trophic factor delivery in future human clinical studies...
  88. ncbi Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve
    C Regala
    Department of Clinical Neuroscience, Section of Otorhinolaryngology, Karolinska Institutet, Karolinska Hospital, PO Box SE-171 76 Stockholm, Sweden
    Exp Neurol 193:326-33. 2005
    ..This may have future clinical applicability in recreating a neuronal conduit following neuronal injury between the inner ear and the central nervous system (CNS)...
  89. ncbi Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells
    Ryu Ichi Kitamura
    Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Endocr J 54:255-64. 2007
    ..Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors...
  90. ncbi Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells
    Eva Vergaño-Vera
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Spain
    Development 133:4367-79. 2006
    ..These findings suggest that, in addition to receiving interneurons from the LGE, the embryonic OB contains molecularly distinct local precursor cells that generate mature GABAergic and dopaminergic neurons...
  91. ncbi Derivation and characterization of lentoid bodies and retinal pigment epithelial cells from monkey embryonic stem cells in vitro
    Masayo Takahashi
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Methods Mol Biol 330:417-29. 2006
    ..We describe the methods to induce retinal pigment epithelial and lens cells from monkey ES cells using stromal cell-derived inducing activity and show the characteristics of those cells in vitro and in vivo...
  92. ncbi A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success
    P Mills
    Unité de Recherche en Génétique Humaine, Centre hospitalier de l Universite Laval, Ste Foy, Quebec, Canada
    Am J Transplant 7:2247-59. 2007
    ..Those combined effects are probably responsible for the enhanced transplantation success. Thus, the MGF-Ct24E peptide is an interesting agent to increase MPC transplantation success in DMD patients...
  93. ncbi Formation of hematopoietic territories and bone by transplanted human bone marrow stromal cells requires a critical cell density
    Mahesh H Mankani
    Division of Plastic Surgery, Department of Surgery, University of California San Francisco, San Francisco, Calif, USA
    Exp Hematol 35:995-1004. 2007
    ..Here, we describe, for the first time, a relationship between BMSC numbers and the extent of bone/hematopoiesis formation in heterotopic transplants...
  94. ncbi Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation
    Dug Keun Lee
    TissueGene, Gaithersburg, Maryland 20877, USA
    Tissue Eng 11:310-8. 2005
    ..These data suggest that cell-mediated gene therapy using TGF-beta1 as a transgene would be a promising treatment for osteoarthritis...
  95. ncbi Optimization of a transplant model to assess skin reconstitution from stem cell-enriched primary human keratinocyte populations
    Normand Pouliot
    Epithelial Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia
    Exp Dermatol 14:60-9. 2005
    ....
  96. ncbi Generation of cardiomyocytes from embryonic stem cells experimental studies
    Agapios Sachinidis
    Department of Neurophysiology, University of Cologne, Germany
    Herz 27:589-97. 2002
    ..Thus, a main challenge in the future will be the establishment of pure lineages of cardiomyocytes derived from human embryonic stem cells...
  97. ncbi Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    Karin Stenderup
    University Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK-8000 Aarhus C, Denmark
    Bone 33:919-26. 2003
    ..In conclusion, aging is associated with decreased proliferative capacity of osteoprogenitor cells, suggesting that decreased osteoblastic cell number, and not function, leads to age-related decrease in bone formation...
  98. ncbi Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice
    K Leriche-Guerin
    Unité de Recherche en Génétique Humaine, Centre de Recherche du Centre Hospitalier de l Universite Laval, CHUL du CHUQ, Ste Foy, QC, Canada
    Neuromuscul Disord 12:167-73. 2002
    ..In the present study, we have investigated whether cell transplantation could permit dysferlin expression in vivo...
  99. ncbi Use of blood outgrowth endothelial cells for gene therapy for hemophilia A
    Yi Lin
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    Blood 99:457-62. 2002
    ..Thus, the use of engineered autologous BOECs, which here resulted in sustained and therapeutic levels of FVIII, may comprise an effective therapeutic strategy for use in gene therapy for hemophilia A...
  100. ncbi Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    J Cell Biol 156:173-84. 2002
    ..Manipulation of hepatic stem cells may provide new insight into therapies for diseases of the digestive system...
  101. ncbi Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity
    Hiroshi Kawasaki
    Department of Medical Embryology and Neurobiology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
    Proc Natl Acad Sci U S A 99:1580-5. 2002
    ..The SDIA method provides an unlimited source of primate cells for the study of pathogenesis, drug development, and transplantation in degenerative diseases such as Parkinson's disease and retinitis pigmentosa...

Research Grants95

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
    ..lt;keyword>Animals</keyword><keyword>Brain/*cytology/embryology</keyword><keyword>Cell Transplantation/methods/*trends</keyword><keyword>Central Nervous System Diseases/*therapy</keyword><..
  2. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2010
    ..bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell transplantation following high dose chemotherapy...
  3. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2010
    ..kill the majority of afflicted patients despite treatment with combination chemotherapy and hematopoietic cell transplantation (HCT)...
  4. Post-transplant vaccines to enhance graft-versus-leukemia responses
    CATHERINE JU YING WU; Fiscal Year: 2010
    A curative graft-versus-leukemia (GvL) response following allogeneic hematopoietic stem cell transplantation (HSCT) results from the: (1) restoration of normal immunity, thus overcoming leukemia- or treatment-induced immune deficiencies;..
  5. Genes, Environment & Neural Stem Cell Transplantation in the Gut
    PANKAJ PASRICHA; Fiscal Year: 2009
    ..It is the purpose of this proposal to study this approach experimentally and determine the biological factors that can optimize the use of neural stem cells for the treatment and perhaps cure of these diseases. ..
  6. Genes, Environment & Neural Stem Cell Transplantation in the Gut
    Pankaj J Pasricha; Fiscal Year: 2010
    ..It is the purpose of this proposal to study this approach experimentally and determine the biological factors that can optimize the use of neural stem cells for the treatment and perhaps cure of these diseases. ..
  7. Training Patients and Partners for HSCT: A Novel Coping Skills Intervention
    Catalina Lawsin; Fiscal Year: 2007
    Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment of hematological malignancies and related disorders with more than 40,000 transplants conducted each year...
  8. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2009
    ..to measure the effectiveness of emerging approaches to neuroprotection and myelin repair, such as stem cell transplantation. Ultimately, developing these biomarkers will allow identification of patients who are most likely to ..
  9. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2010
    ..to measure the effectiveness of emerging approaches to neuroprotection and myelin repair, such as stem cell transplantation. Ultimately, developing these biomarkers will allow identification of patients who are most likely to ..
  10. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2011
    ..unwanted immune responses that occur during autoimmune disease or as a consequence of hematopoietic stem cell transplantation (HSCT) or tissue transplant rejection reactions...
  11. Elucidating the role of T-regs in engraftment, GVHD, and DLI immunotherapy
    Christene A Huang; Fiscal Year: 2010
    Hematopoietic cell transplantation (HCT) can cure genetic blood disorders through the replacement of defective blood cells by healthy cells. However, life-threatening complications limit the use of HCT therapy in the clinic...
  12. Elucidating the role of T-regs in engraftment, GVHD, and DLI immunotherapy
    CHRISTENE HUANG; Fiscal Year: 2009
    Hematopoietic cell transplantation (HCT) can cure genetic blood disorders through the replacement of defective blood cells by healthy cells. However, life-threatening complications limit the use of HCT therapy in the clinic...
  13. Elucidating the role of T-regs in engraftment, GVHD, and DLI immunotherapy
    Christene A Huang; Fiscal Year: 2010
    Hematopoietic cell transplantation (HCT) can cure genetic blood disorders through the replacement of defective blood cells by healthy cells. However, life-threatening complications limit the use of HCT therapy in the clinic...
  14. Regeneration of the Lower Urinary Tract in Nonhuman Primates
    James Williams; Fiscal Year: 2009
    The concept of regenerating damaged tissue using selective cell transplantation has been applied clinically for a variety of muscle disorders, including stress urinary incontinence (SUI), which is a manifestation of several kinds of ..
  15. Population Pharmacokinetics/Pharmacodynamics in Nonablative Stem Cell Recipients
    Jeannine McCune; Fiscal Year: 2009
    PROJECT SUMMARY Nonablative hematopoietic stem cell transplantation (HCT) with an unrelated donor graft has greatly expanded the number of patients suffering from hematologic diseases and malignancies who can be cured by HCT...
  16. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2010
    Iron overload is common in patients undergoing hematopoietic cell transplantation (HCT) and recent reports show increased non-relapse mortality in patients with iron overload as determined by increased levels of ferritin...
  17. Bispecific Antibody Engineering for AML RIT
    OLIVER W contact PRESS; Fiscal Year: 2010
    ..the majority of afflicted patients despite treatment with combination chemotherapy and allogeneic stem cell transplantation (SCT)...
  18. Stem Cell Transplantation for Hemoglobinopathies in Dogs
    JOHN HEARST; Fiscal Year: 2003
    ..the completion of this validation through the support of US Public Health Service Grant R01 HL63456 "Stem Cell Transplantation to Establish AIIochimerism," this project is now entering a development phase that should ultimately lead ..
  19. COMPREHENSIVE SICKLE CELL CENTER
    Winfred Wang; Fiscal Year: 2006
    ..Namely, supportive care, chronic transfusion, drug therapy or stem cell transplantation, to our patients and in so doing to implement effective clinical research protocols to evaluate these ..
  20. Cord Blood Stem Cell Transplantation, Hemoglobinopathies
    JOHN HEARST; Fiscal Year: 2003
    ..the completion of this validation through the support of US Public Health Service Grant R01 HL63456, "Stem Cell Transplantation to Establish Allochimerism," this project is now entering a development phase that should ultimately lead ..
  21. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    Over the past decade, the use of immune deficient mice as recipients for human hematopoietic stem cell transplantation has dramatically improved stem cell research...
  22. Restoring Hematopoiesis Following Radiation Injury
    Amelia Bartholomew; Fiscal Year: 2005
    ..can be treated with both colony-stimulating factors, aggressive use of anti-microbials, and stem cell transplantation. The strategy involving allogeneic stem cell transplantation, due to the morbidity and mortality associated ..
  23. Immune Recovery Following LLME Treated Cell Therapy
    Joanne Filicko; Fiscal Year: 2006
    Allogeneic hematopoietic stem cell transplantation (HSCT) is the preferred therapy for a variety of disorders...
  24. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence...
  25. IN UTERO STEM CELL TRANSPLANTATION
    Esmail D Zanjani; Fiscal Year: 2010
    In utero hematopoietic stem cell transplantation (IUSCT) is a promising therapeutic approach for many genetic disorders...
  26. IN UTERO STEM CELL TRANSPLANTATION
    Esmail Zanjani; Fiscal Year: 2009
    In utero hematopoietic stem cell transplantation (IUSCT) is a promising therapeutic approach for many genetic disorders...
  27. CELLULAR IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCY
    John Levine; Fiscal Year: 2006
    ..The candidate, Dr. John Levine, is a junior faculty member in the Blood and Marrow Stem Cell Transplantation Program at the University of Michigan. Dr...