cell transplantation

Summary

Summary: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.

Top Publications

  1. ncbi Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
  2. ncbi Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials
    Dongming Hou
    Indiana University School of Medicine, Indianapolis, IN, USA
    Circulation 112:I150-6. 2005
  3. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
  4. pmc Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma
    Thomas V Johnson
    Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 51:2051-9. 2010
  5. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
  6. pmc Myogenic specification of side population cells in skeletal muscle
    Atsushi Asakura
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada
    J Cell Biol 159:123-34. 2002
  7. pmc Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source
    J R Beauchamp
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Cell Biol 144:1113-22. 1999
  8. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
  9. ncbi Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Cell Transplant 13:595-600. 2004
  10. ncbi Schwann cell transplantation for CNS repair
    A A Lavdas
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vas Sofias Avenue, 11521 Athens, Greece
    Curr Med Chem 15:151-60. 2008

Detail Information

Publications339 found, 100 shown here

  1. ncbi Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
    ..For this reason, we analyzed 10 patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI...
  2. ncbi Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials
    Dongming Hou
    Indiana University School of Medicine, Indianapolis, IN, USA
    Circulation 112:I150-6. 2005
    ..We evaluated the short-term fate of peripheral blood mononuclear cells (PBMNCs) after intramyocardial (IM), intracoronary (IC), and interstitial retrograde coronary venous (IRV) delivery in an ischemic swine model...
  3. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  4. pmc Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma
    Thomas V Johnson
    Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 51:2051-9. 2010
    ..Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part by ..
  5. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  6. pmc Myogenic specification of side population cells in skeletal muscle
    Atsushi Asakura
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada
    J Cell Biol 159:123-34. 2002
    ....
  7. pmc Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source
    J R Beauchamp
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Cell Biol 144:1113-22. 1999
    ..This minority is behaviorally distinct, slowly dividing in tissue culture, but rapidly proliferative after grafting, suggesting a subpopulation with stem cell-like characteristics...
  8. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
    ..Thus, these studies establish that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration...
  9. ncbi Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Cell Transplant 13:595-600. 2004
    This study assessed the effectiveness of autologous bone marrow stromal cell transplantation for the repair of full-thickness articular cartilage defects in the patellae of a 26-year-old female and a 44-year-old male...
  10. ncbi Schwann cell transplantation for CNS repair
    A A Lavdas
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vas Sofias Avenue, 11521 Athens, Greece
    Curr Med Chem 15:151-60. 2008
    ..In this review we summarize data from the recent literature regarding the use of SCs in CNS repair and discuss the prospects for future therapeutic applications...
  11. ncbi Lamina propria and olfactory bulb ensheathing cells exhibit differential integration and migration and promote differential axon sprouting in the lesioned spinal cord
    Miranda W Richter
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 25:10700-11. 2005
    ....
  12. pmc Cellular therapy with Ixmyelocel-T to treat critical limb ischemia: the randomized, double-blind, placebo-controlled RESTORE-CLI trial
    Richard J Powell
    Department of Surgery, Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Mol Ther 20:1280-6. 2012
    ..Treatment effect in post hoc analyses of patients with baseline wounds was more pronounced (TTF: P < 0.0001, AFS: P = 0.0802, logrank test). Ixmyelocel-T treatment was well tolerated and may offer a potential new treatment option...
  13. ncbi Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Neurol 229:88-98. 2011
    ..b>Cell transplantation is typically performed within a few days after lesion induction, i.e...
  14. ncbi Prospective isolation of skeletal muscle stem cells with a Pax7 reporter
    Darko Bosnakovski
    Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Stem Cells 26:3194-204. 2008
    ..These results establish a novel animal model for the study of muscle stem cell physiology and a culture system for expansion of engraftable muscle progenitors...
  15. pmc Cell transplantation in lumbar spine disc degeneration disease
    C Hohaus
    Department of Neurosurgery, BG Clinic Bergmannstrost, Halle, Germany
    Eur Spine J 17:492-503. 2008
    ..In the interim analyses we evaluated that patients who received autologous disc cell transplantation had greater pain reduction at 2 years compared with patients who did not receive cells following their ..
  16. ncbi Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury
    Paul Lu
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093, USA
    J Neurosci 26:11120-30. 2006
    ....
  17. ncbi Cardiac cell therapy trials: chronic myocardial infarction and congestive heart failure
    Philippe Menasche
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Cardiovascular Surgery, University Paris Descartes, Faculte de Medecine, INSERM U 633, Paris, France
    J Cardiovasc Transl Res 1:201-6. 2008
    ....
  18. ncbi Nasal OEC transplantation promotes respiratory recovery in a subchronic rat model of cervical spinal cord contusion
    J C Stamegna
    Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, CRN2M, Centre National de la Recherche Scientifique UMR6231, Marseille, France
    Exp Neurol 229:120-31. 2011
    ..This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair...
  19. ncbi Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line
    Guodong Li
    Cardiovascular Research Institute, National University Medical Institutes, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Stem Cell Res 2:41-55. 2009
    ..After transplantation, these cells reversed hyperglycemia in streptozotocin-treated SCID mice and did not form teratomas...
  20. ncbi Hepatitis C virus replication in mice with chimeric human livers
    D F Mercer
    Surgical-Medical Research Institute, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Nat Med 7:927-33. 2001
    ..These chimeric mice represent the first murine model suitable for studying the human hepatitis C virus in vivo...
  21. ncbi Muscle engraftment of myogenic progenitor cells following intraarterial transplantation
    Estanislao Bachrach
    Howard Hughes Medical Institute, Program in Genomics, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Muscle Nerve 34:44-52. 2006
    ....
  22. pmc Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Nucl Med 51:7-15. 2010
    ..Nonetheless, clinical improvement was significant only in younger (age < or = 60 y) transplant recipients, as indicated by a reduction in Unified Parkinson's Disease Rating Scale (UPDRS) motor scores...
  23. ncbi Homing and engraftment of progenitor cells: a prerequisite for cell therapy
    Emmanouil Chavakis
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Mol Cell Cardiol 45:514-22. 2008
    ..The review will focus on the mechanisms underlying homing of adult bone marrow-derived hematopoietic cells, mesenchymal stem cells, and vasculogenic circulating cells and discuss strategies how to optimize cell engraftment...
  24. pmc Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Cell Biol 156:173-84. 2002
    ..Manipulation of hepatic stem cells may provide new insight into therapies for diseases of the digestive system...
  25. pmc Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice
    Budd A Tucker
    Department of Ophthalmology, Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e18992. 2011
    ..As such, adult fibroblast-derived iPSCs provide a viable source for the production of retinal precursors to be used for transplantation and treatment of retinal degenerative disease...
  26. pmc Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    PLoS ONE 4:e5959. 2009
    ..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs...
  27. ncbi Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium?
    J Leor
    Cardiac Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Circulation 102:III56-61. 2000
    ..The heart is therefore an attractive target for tissue engineering to replace infarcted myocardium and enhance cardiac function. We tested the feasibility of bioengineering cardiac tissue within novel 3-dimensional (3D) scaffolds...
  28. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
  29. ncbi Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl₄-treated mice
    Ursula Manuelpillai
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Cell Transplant 19:1157-68. 2010
    ..hAEC transplantation into immunocompetent mice leads to cell engraftment, reduced hepatocyte apoptosis, and decreased hepatic inflammation and fibrosis...
  30. ncbi Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: an interim report on safety considerations and possible outcomes
    Hooshang Saberi
    Department of Neurosurgery and Iranian Tissue Bank, Tehran University of Medical Sciences Tehran University, Tehran, Iran
    Neurosci Lett 443:46-50. 2008
    Several experimental studies have introduced Schwann cell transplantation as a means of recovery in animal models of spinal cord injury (SCI)...
  31. ncbi Massive mechanical loss of microspheres with direct intramyocardial injection in the beating heart: implications for cellular cardiomyoplasty
    Carolyn J Teng
    Division of Cardiac Surgery, McGill University, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 132:628-32. 2006
    ..Studies have demonstrated a significant and rapid loss of implanted cells, which is thought to be biologically caused. We hypothesized that mechanical loss of cells from the contracting myocardium might actually be the main culprit...
  32. ncbi Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model
    Thomas V Johnson
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 49:3503-12. 2008
    ..To develop and characterize a retinal explant culture system to facilitate investigation of novel methods of improving retinal stem cell therapy...
  33. ncbi Proximodistal patterning during limb regeneration
    Karen Echeverri
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstra, 108 01307 Dresden, Germany
    Dev Biol 279:391-401. 2005
    ....
  34. ncbi Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia
    A Kawamoto
    Division of Cardiovascular Research, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Circulation 103:634-7. 2001
    ..CONCLUSIONS: Ex vivo expanded EPCs incorporate into foci of myocardial neovascularization and have a favorable impact on the preservation of left ventricular function...
  35. pmc Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor
    Nils Ole Schmidt
    Neurosurgical Oncology Laboratory, Department of Neurosurgery, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 7:623-9. 2005
    ..Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors...
  36. ncbi 'Green mice' as a source of ubiquitous green cells
    M Okabe
    Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    FEBS Lett 407:313-9. 1997
    ..The fluorescent nature of the cells from these transgenic mouse lines would facilitate their use in many kinds of cell transplantation experiments.
  37. ncbi Microcontact printing on human tissue for retinal cell transplantation
    Christina J Lee
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA
    Arch Ophthalmol 120:1714-8. 2002
    ....
  38. ncbi Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation
    Kelli P A MacDonald
    The Queensland Institute of Medical Research, and the Department of Pathology, University of Queensland, Herston, Australia
    Blood 101:2033-42. 2003
    ..DC) expansion and may be an alternative to G-CSF for the mobilization of stem cells for allogeneic stem cell transplantation (SCT)...
  39. ncbi Basement membranes and artificial substrates in cell transplantation
    Carl Sheridan
    Unit of Ophthalmology, Department of Medicine, University Clinical Departments, University of Liverpool, UK
    Graefes Arch Clin Exp Ophthalmol 242:68-75. 2004
  40. ncbi Cultured human corneal endothelial cell transplantation with a collagen sheet in a rabbit model
    Tatsuya Mimura
    Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Japan
    Invest Ophthalmol Vis Sci 45:2992-7. 2004
    ..To evaluate the function of cultured human corneal endothelial cells (HCECs) in vivo and the feasibility of HCEC transplantation with a collagen sheet as the substitute carrier of HCECs...
  41. ncbi Cell transplantation in Parkinson's disease: how can we make it work?
    Christian Winkler
    Department of Neurology, Hannover Medical School, 30625 Hannover, Germany
    Trends Neurosci 28:86-92. 2005
    ....
  42. pmc Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis
    Lianhua Bai
    Department of Neurosciences, Center for Translational Neuroscience, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Neurosci Bull 29:239-50. 2013
    ..These results suggested that adult NG2(+) cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS...
  43. ncbi Technical aspects of spinal cord injections for cell transplantation. Clinical and translational considerations
    James Guest
    The Miami Project to Cure Paralysis, University of Miami, FL, USA
    Brain Res Bull 84:267-79. 2011
    ..We also suggest that injectate backout or extrusion be reinterpreted as a clear indicator of excessive intraparenchymal pressure. The strengths and weaknesses of alternatives to direct intraparenchymal injection are also discussed...
  44. ncbi Human umbilical cord-derived Schwann-like cell transplantation combined with neurotrophin-3 administration in dyskinesia of rats with spinal cord injury
    Guo Yan-Wu
    Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, 253 Gongye Road, 510282 Guangzhou, China
    Neurochem Res 36:783-92. 2011
    ..further tested the effect of Schwann-like cell grafting combined with NT-3 administration at the site of cell transplantation. The results showed that NT-3 administration significantly promoted the survival of the grafted cells in ..
  45. ncbi Safety of intramedullary Schwann cell transplantation for postrehabilitation spinal cord injuries: 2-year follow-up of 33 cases
    Hooshang Saberi
    Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Neurosurg Spine 15:515-25. 2011
    ..This study was conducted to evaluate safety issues 2 years after intramedullary Schwann cell transplantation in 33 consecutively selected patients with SCI.
  46. ncbi Osteogenic matrix sheet-cell transplantation using osteoblastic cell sheet resulted in bone formation without scaffold at an ectopic site
    Manabu Akahane
    Department of Orthopaedic Surgery, Nara Medical University School of Medicine, Nara, Japan
    J Tissue Eng Regen Med 2:196-201. 2008
    ..Our present results indicate that MSCs can be cultured as sheet structures, and the resulting sheets themselves or HA-sheet composites represent osteogenic implants that can be used for hard tissue reconstruction...
  47. pmc Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with hereditary ataxia
    Wan Zhang Yang
    Shenzhen Beike Cell Engineering Research Institution, Shenzhen, China
    J Transl Med 9:65. 2011
    ..This open label treatment study used human umbilical cord blood-derived mononuclear cells (CBMC) combined with rehabilitation training as potential disease modulators...
  48. ncbi Motor recovery following olfactory ensheathing cell transplantation in rats with spinal cord injury
    George Tharion
    Department of Physical Medicine and Rehabilitation, Christian Medical College, Vellore, Tamil Nadu, India
    Neurol India 59:566-72. 2011
    ..However, there are conflicting reports about the success rates with OEC...
  49. pmc Stem cells, cell transplantation and liver repopulation
    Michael Oertel
    Marion Bessin Liver Research Center, Division of Hepatology, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochim Biophys Acta 1782:61-74. 2008
    ..availability, attention has been focused on the possibility to restore liver mass and function through cell transplantation. Stem cells are a promising source for liver repopulation after cell transplantation, but whether or not ..
  50. pmc Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
    Hyun Jai Cho
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    J Exp Med 204:3257-69. 2007
    ..effects have emerged as important mechanisms mediating therapeutic effects of stem or progenitor cell transplantation. Here, we investigated the expression patterns and sources of humoral factors and their regional and ..
  51. pmc Imparting regenerative capacity to limbs by progenitor cell transplantation
    Gufa Lin
    Stem Cell Institute, University of Minnesota, 2001 6 th Street S E, Minneapolis, MN 55455, USA
    Dev Cell 24:41-51. 2013
    ..These findings have obvious implications for the development of a technology to promote limb regeneration in mammals...
  52. pmc Neural crest origin of olfactory ensheathing glia
    Perrine Barraud
    Department of Physiology, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 107:21040-5. 2010
    ..our results also raise the possibility that patient-derived neural crest stem cells could in the future provide an abundant and accessible source of autologous OECs for cell transplantation therapy for the injured central nervous system.
  53. ncbi Cartilage repair: generations of autologous chondrocyte transplantation
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Austria
    Eur J Radiol 57:24-31. 2006
    ..These biomaterials secure the cells in the defect area and enhance their proliferation and differentiation...
  54. ncbi Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation
    Mario Arpinati
    Centro di Ricerca sull Immunologia dei Trapianti, Istituto di Ematologia e Oncologia Medica Seragnoli, Universita di Bologna, Via Massarenti 9, Bologna 40138, Italy
    Transpl Immunol 11:345-56. 2003
    ..host disease after allogeneic hematopoietic stem cell transplantation (HSCT)...
  55. pmc Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials
    Curt R Freed
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    Neurotherapeutics 8:549-61. 2011
    ..Our trial has provided the first controlled evidence that dopamine cell transplants can improve the clinical state of patients with Parkinson's disease...
  56. pmc Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives
    Philippe A Lysy
    Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Cliniques Saint Luc, 10 av Hippocrate, Brussels B 1200, Belgium
    World J Gastroenterol 14:3464-70. 2008
    Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism...
  57. ncbi Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy
    Marcel M Daadi
    Department of Neurosurgery and Stanford Stroke Center, MSLS P309, 1201 Welch Road, Stanford University School of Medicine, Stanford, CA 94305 5487, USA
    Regen Med 4:251-63. 2009
    ..compelling source of cells to study tissue histogenesis and to apply in a wide array of tissue engineering, cell transplantation therapy and drug discovery applications...
  58. ncbi A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee
    G Bentley
    Royal National Orthopaedic Hospital, Stanmore, England, UK
    J Bone Joint Surg Br 85:223-30. 2003
    ..The results for ACI are comparable with those in other studies, but those for mosaicplasty suggest that its continued use is of dubious value...
  59. ncbi Human amniotic epithelial cells possess hepatocyte-like characteristics and functions
    Seiji Takashima
    Department of Organ Regeneration, Institutes of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    Cell Struct Funct 29:73-84. 2004
    ..These observations suggest that transplantation of human amniotic epithelial cells and/or amnion could be novel therapeutic strategy for treatment of hepatic diseases, including alpha(1)-antitrypsin deficiency...
  60. ncbi Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation
    S Ehnert
    Department of Traumatology, MRI, Technische Universitat Munchen, Munich, Germany
    Cell Transplant 20:1465-77. 2011
    ..The autologous approach presented here might also be useful in other stem cell preparation processes where cell activation during generation shall be kept to a minimum...
  61. ncbi Tolerogenic functions of human leukocyte antigen G: from pregnancy to organ and cell transplantation
    Nathalie Rouas-Freiss
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, Institut Universitaire d Hematologie, 1 avenue Claude Vellefaux, 75010 Paris, France
    Transplantation 84:S21-5. 2007
    ..In this paper, we focus our attention on the relevance of HLA-G in transplantation in the light of recent data associating regulatory T cells and HLA-G, and which provide evidence of the role of HLA-G in improving graft acceptance...
  62. ncbi Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: a double blind video-based analysis
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Mov Disord 24:336-43. 2009
    ..Off-medication dyskinesias are common following transplantation and may represent a prolonged form of diphasic dyskinesias...
  63. ncbi Bioengineered human corneal endothelium for transplantation
    Jui Yang Lai
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Arch Ophthalmol 124:1441-8. 2006
    ..To investigate whether the bioengineered human corneal endothelial cell (HCEC) monolayers harvested from thermoresponsive culture supports could be used as biological tissue equivalents...
  64. pmc Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation
    Ian Y Chen
    Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging Biol 11:178-87. 2009
    ....
  65. ncbi Melanocyte-keratinocyte cell transplantation for stable vitiligo
    Sanjeev V Mulekar
    Noble Clinic, Pune, India
    Int J Dermatol 42:132-6. 2003
    ..Vitiligo is a common disorder with a worldwide prevalence of 1-2%. In India the psychological and social impact of the disease is significant and is detrimental to patients...
  66. ncbi Osteogenic potential of cultured human periosteum-derived cells - a pilot study of human cell transplantation into a rat calvarial defect model
    Yoshiro Sakata
    Department of Oral and Maxillofacial Reconstructive Surgery Head Prof Dr Toshio Sugahara, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Craniomaxillofac Surg 34:461-5. 2006
    ..The osteogenic potential of cultured periosteal cells has also been reported. The findings of bone formation induced by cultured human periosteum-derived cells using a rat model are presented...
  67. ncbi Beating and arrested intramyocardial injections are associated with significant mechanical loss: implications for cardiac cell transplantation
    Wes Hudson
    Division of Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Surg Res 142:263-7. 2007
    ..Mechanical and biological mechanisms may account for observed donor cell loss. This study examines acute mechanical loss during intramyocardial injections in beating and arrested hearts...
  68. ncbi Creation of a prevascularized site for cell transplantation in rats
    Philipp Stiegler
    Department of Surgery, Division of Transplantation Surgery, Medical University Graz, Graz, Austria
    Xenotransplantation 17:379-90. 2010
    ..The aim of this study was to create a prevascularized site for cell transplantation in rats and test its effectiveness with microencapsulated HEK293 cells.
  69. ncbi Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a cotransplantation approach with fetal ventral mesencephalic cells
    A K Agrawal
    Developmental Toxicology Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226 001, India
    Neurobiol Dis 16:516-26. 2004
    ..The results suggest that cotransplantation of OECs and VMC may be a better approach for functional restoration in 6-OHDA-induced rat model of Parkinson's disease...
  70. ncbi Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair
    Yuben Moodley
    F R A C P School of Medicine and Pharmacology, University of Western Australia, 50 Murray Street, Perth, Western Australia 6000, Australia
    Am J Respir Crit Care Med 182:643-51. 2010
    ..Cellular therapies that could restore pneumocytes and reduce inflammation and fibrosis would be a major advance in management...
  71. pmc Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells
    Prabhat S Kunwar
    Howard Hughes Medical Institute, Developmental Genetics Program, New York University School of Medicine, New York, New York, USA
    PLoS Biol 1:E80. 2003
    ..Recently, the chemokine receptor CXCR4 was shown to direct migration in vertebrate germ cells. Thus, germ cells may more generally use GPCR signaling to navigate the embryo toward their target...
  72. ncbi First test of a "high-density injection" protocol for myogenic cell transplantation throughout large volumes of muscles in a Duchenne muscular dystrophy patient: eighteen months follow-up
    Daniel Skuk
    Unité de Recherche en Génétique Humaine, Centre hospitalier de l Universite Laval, Laurier, Que, Canada
    Neuromuscul Disord 17:38-46. 2007
    ..The patient was immunosuppressed with tacrolimus. The protocol of cell transplantation was well tolerated and did not cause permanent sequels...
  73. pmc Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injury
    Bruce H Dobkin
    Department of Neurology, Neurorehabilitation and Research Program, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1769, USA
    Neurorehabil Neural Repair 20:5-13. 2006
    ..In China, fetal brain tissue has been transplanted into the lesions of more than 400 patients with spinal cord injury (SCI). Anecdotal reports have been the only basis for assuming that the procedure is safe and effective...
  74. ncbi Neural progenitors from human embryonic stem cells
    B E Reubinoff
    The Goldyne Savad Institute of Gene Therapy, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Nat Biotechnol 19:1134-40. 2001
    ..Our observations set the stage for future developments that may allow the use of human ES cells for the treatment of neurological disorders...
  75. pmc Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow
    Atsushi Nagai
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    PLoS ONE 2:e1272. 2007
    ....
  76. ncbi Limbal stem cell transplantation in chronic inflammatory eye disease
    C Michael Samson
    Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 109:862-8. 2002
    The goal of this study was to describe the outcome of limbal stem cell transplantation (LSCT) in patients with severe ocular surface disease caused by underlying chronic inflammatory eye disease.
  77. ncbi Impaired spinal cord remyelination by long-term cultured adult porcine olfactory ensheathing cells correlates with altered in vitro phenotypic properties
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Xenotransplantation 17:71-80. 2010
    ..Here, we studied the impact of the culturing interval on the remyelinating capacity of adult porcine OECs...
  78. ncbi A tissue-engineered approach towards retinal repair: scaffolds for cell transplantation to the subretinal space
    Sara Royce Hynes
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Graefes Arch Clin Exp Ophthalmol 248:763-78. 2010
    ..However, these transplants have yet to result in a clinical treatment for retinal degeneration...
  79. ncbi Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results
    J S Fink
    Genzyme Corporation, Cambridge, MA 02139, USA
    Cell Transplant 9:273-8. 2000
    ....
  80. ncbi Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells
    Dilek Colak
    Helmhotz Center Munich, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 28:434-46. 2008
    ..Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis...
  81. ncbi A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success
    P Mills
    Unité de Recherche en Génétique Humaine, Centre hospitalier de l Universite Laval, Ste Foy, Quebec, Canada
    Am J Transplant 7:2247-59. 2007
    ..Those combined effects are probably responsible for the enhanced transplantation success. Thus, the MGF-Ct24E peptide is an interesting agent to increase MPC transplantation success in DMD patients...
  82. pmc Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    Osahiko Tsuji
    Department of Physiology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 107:12704-9. 2010
    ..activities in different contexts, should be investigated to establish their safety and effectiveness for cell transplantation therapies...
  83. ncbi Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart
    Muhammad Idris Niagara
    Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45267 0529, USA
    Circ Res 100:545-55. 2007
    ..Transplantation of PC SkMs for heart cell therapy is an innovative approach in the clinical perspective...
  84. ncbi Development of a novel method for cell transplantation through the coronary artery
    K Suzuki
    Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine at the Heart Science Centre, Harefield Hospital, Middlesex, UK
    Circulation 102:III359-64. 2000
    b>Cell transplantation is a promising strategy to treat end-stage heart failure. At present, a popular method to deliver cells into the heart is direct intramuscular injection...
  85. ncbi Concise review: making a retina--from the building blocks to clinical applications
    Valerie A Wallace
    Vision Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Stem Cells 29:412-7. 2011
    ..This review summarizes the major cellular and molecular events that occur during retinal development and highlights how this knowledge may be harnessed for new therapeutic strategies to treat retinal disease...
  86. ncbi Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    E Lagasse
    StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA
    Nat Med 6:1229-34. 2000
    ....
  87. ncbi New insights and new therapies in vitiligo
    Pearl E Grimes
    Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
    JAMA 293:730-5. 2005
  88. ncbi Transplanted adult bone marrow cells repair myocardial infarcts in mice
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 938:221-9; discussion 229-30. 2001
    ..These in vivo findings demonstrate the capacity of highly enriched Lin- c-kit+ adult bone marrow cells to acutely regenerate functional myocardium within an infarcted region...
  89. pmc Human corneal endothelial cell transplantation in a human ex vivo model
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 50:2123-31. 2009
    ....
  90. pmc Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta)
    Alice F Tarantal
    Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, CA 95616 8542, USA
    Transplantation 88:38-41. 2009
    ....
  91. ncbi Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart
    Paul W M Fedak
    Division of Cardiac Surgery, Department of Cardiac Sciences and Surgery, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    Semin Thorac Cardiovasc Surg 20:87-93. 2008
    ..b>Cell transplantation is an innovative biologic therapy that may restore myocardial structure and function in failing hearts...
  92. ncbi The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats
    Denis Dufrane
    Faculte de Medecine, Laboratory of Experimental Surgery, Universite Catholique de Louvain, CHEX 5570, Avenue Hippocrate 55, B 1200 Brussels, Belgium
    Biomaterials 27:3201-8. 2006
    ..In rats, the peritoneum site seems not appropriate for promoting the engraftment of encapsulated pig islets. Kidney subcapsular and subcutaneous spaces represent an interesting alternative...
  93. pmc Cell delivery: from cell transplantation to organ engineering
    Alejandro Soto-Gutierrez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Center for Engineering in Medicine, Boston, MA 76104, USA
    Cell Transplant 19:655-65. 2010
    ....
  94. ncbi Cell transplantation for endocrine disorders
    M K Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135 710, Seoul, South Korea
    Adv Drug Deliv Rev 42:103-20. 2000
    ..The organ or cell transplantation would be a more physiological approach to the treatment of endocrine disorders...
  95. ncbi Neural cell transplantation effects on sciatic nerve regeneration after a standardized crush injury in the rat
    A L Luis
    Centro de Estudos de Ciência Animal CECA, Instituto de Ciências e Tecnologias Agrárias e Agro Alimentares ICETA, Universidade do Porto, Campus Agrário de Vairão, Rua P Armando Quintas, Vairao, Portugal
    Microsurgery 28:458-70. 2008
    ..To set up an appropriate experimental model for investigating the effects of neural cell transplantation, we have recently described the sequence of functional and morphologic changes occurring after a ..
  96. ncbi A novel method of cryopreservation of rat and human hepatocytes by using encapsulation technique and possible use for cell transplantation
    Takeshi Aoki
    Second Department of Surgery, School of Medicine, Showa University, Tokyo, Japan
    Cell Transplant 14:609-20. 2005
    Encapsulated hepatocyte transplantation is a promising approach to cell transplantation without immunosuppression as an alternative to whole organ liver transplantation...
  97. pmc The design of clinical trials for cell transplantation into the central nervous system
    Pierre Cesaro
    Department of Clinical Neurosciences and Institut National de la Santé et de la Recherche Médicale U 421 Hospital Henri Mondor, 94000 Creteil, France
    NeuroRx 1:492-9. 2004
  98. ncbi Hepatocyte transplantation through the hepatic vein: a new route of cell transplantation to the liver
    Yuichiro Goto
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, Tokyo, Japan
    Cell Transplant 20:1259-70. 2011
    ..This study demonstrates a novel approach of transplanting hepatocytes into the liver through retrograde hepatic vein infusion as the means to target cell implantation to the pericentral zone...
  99. pmc Adrenocortical cell transplantation reverses a murine model of adrenal failure
    Tatiana Zupekan
    Division of Pediatric Surgery, University of California, Los Angeles, CA 90095 7098, USA
    J Pediatr Surg 46:1208-13. 2011
    ..Although adrenal insufficiency can be managed with steroid replacement, transplantation of adrenocortical cells may represent a more definitive therapy...
  100. pmc Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells
    Myung Soo Cho
    Research and Development Center, Jeil Pharmaceutical Co, Ltd, Yongin 449 861, Korea
    Proc Natl Acad Sci U S A 105:3392-7. 2008
    ..In summary, our study paves the way for the large-scale generation of purer and functional DA neurons for future clinical applications...
  101. ncbi Olfactory ensheathing cells from the nose: clinical application in human spinal cord injuries
    Alan Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith Unversity, Brisbane, QLD 4111, Australia
    Exp Neurol 229:174-80. 2011
    ..A Phase I clinical trial demonstrated that autologous olfactory ensheathing cell transplantation is safe, with no adverse outcomes recorded for three years following transplantation...

Research Grants77

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..The Natural History of Ocular Graft-Versus Host Disease Number: 11-EI-0173 Summary: Background: - Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..The Natural History of Ocular Graft-Versus Host Disease Number: 11-EI-0173 Summary: Background: - Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders...
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..In addition, we have been prospectively evaluating new approaches to stem cell transplantation in order to decrease morbidity and increase access for patients without allogeneic matches64-67...
  4. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..number;keywords;keyword>Animals</keyword;keyword>Brain/*cytology/embryology</keyword;keyword>Cell Transplantation/methods/*trends</keyword;keyword>Central Nervous System Diseases/*therapy</keyword;keyword>..
  5. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is an established treatment for benign and malignant hemato- logic diseases in children...
  6. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..RELEVANCE: Islet cell transplantation reverses hyperglycemia and normalizes metabolic control...
  7. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    Allogeneic stem cell transplantation (allo-SCT) is potentially curative therapy for a patients suffering from leukemia, lymphoma and multiple myeloma...
  8. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..months, yet these patients are often ineligible for life-saving high dose chemotherapy and autologous stem cell transplantation. It results from the deposition of misfolded amyloid proteins derived from immunoglobulin light chains and ..
  9. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  10. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The advent of artificial tissues, cord blood therapies, cell transplantation procedures, and the desire to bank germ cells have driven the need to establish a means to reliably store biological ..
  11. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  12. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is a therapeutic procedure that is used to treat advanced hematologic malignancies or other blood disorders...
  13. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..indicate that it may be feasible to create a conditional inbred SCID Ada KO rat line suitable for human cell transplantation studies...
  14. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Graft-versus-host disease (GvHD) is the major limiting factor to the widespread use of allogeneic stem cell transplantation. GvHD is due to the recognition by donor T cells of minor or major MHC disparities found on antigen-..
  15. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..disorders and statistics, and through mentored research training in primary tissue culture, cell transplantation, behavioral analysis of transgenic mice, gene expression microarray experiments using the translating ..
  16. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..Hematopoietic stem cell transplantation can reduce some manifestations, but has a 15% mortality rate, costs $130,000, and requires a compatible ..
  17. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..Finally, we will evaluate tubular cell transplantation as an innovative therapy for renal failure...
  18. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Long term, these findings have the potential to identify HSC transplantation, and not the transplantation of MSCs or progenitor cells, as the therapy of choice for this collagen disorder. ..
  19. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..protocol that is clinically applicable using fully differentiated stem cells in bioartifical organ/cell transplantation. PUBLIC HEALTH RELEVANCE: This pilot study may lead to a new strategy that uses thermal treatments to ..
  20. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..gene expression regulation in HSC and LIC will be characterized using in vivo models, such as stem cell transplantation assays...
  21. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..Project Narrative Although hematopoietic stem cell transplantation is the only curative therapy for many blood-related disorders, associated risks often limit the application ..
  22. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2013
    ..kill the majority of afflicted patients despite treatment with combination chemotherapy and hematopoietic cell transplantation (HCT)...
  23. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..KUMC that collaborates on the conduct of clinical trials for autologous and allogeneic hematopoietic stem cell transplantation (HSCT)...
  24. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..of stem cell therapies which could delay or ameliorate the pathologies associated with aging;therefore, identifying strategies, such as stem cell transplantation, is essential for maintaining the health of our aging population.
  25. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) has increased the survival of children and adults afflicted with malignant and non-malignant hematological diseases...
  26. Optimization of adoptive immunotherapy with autologous CD20-specific T cells
    Brian Till; Fiscal Year: 2013
    ..and infused into patients with relapsed or refractory aggressive B cell lymphoma following autologous stem cell transplantation. We believe this approach addresses several of the weaknesses identified in our two previous CD20 CAR ..
  27. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..of this project will provide a renewable source of autologous hepatocytes that, after additional modification and scale up, could be translated into cell transplantation-based treatment of CN1 and many other inherited liver diseases.
  28. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2013
    ..problem of relapse of B-lineage acute lymphoblastic leukemia (B-ALL) after allogeneic hematopoietic stem-cell transplantation (HSCT)...
  29. DNA Methylation Control Hematopoietic Stem Cell Lineage Differentiation
    GRANT ANTHONY CHALLEN; Fiscal Year: 2013
    ..interests of the faculty of these Centers includes hematopoiesis, stem cell biology, hemopoietic stem cell transplantation, gene therapy, immunotherapy, and vector development and provides ample opportnity for collaboration to ..
  30. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    Grover Bagby; Fiscal Year: 2009
    ..Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  31. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..Hematopoietic stem cell transplantation (HSCT) is highly curative (up to 95% survival) only if the SCID infants are recognized early in life, prior ..
  32. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) can cure a variety of benign and malignant diseases but graft versus host disease (GvHD), mediated by donor T cells, remains a primary cause of ..
  33. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..the regeneration of the niche and recovery of hematopoiesis following a stressful challenge such as stem cell transplantation or 5-fluorouracyl (5FU) administration...
  34. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..This is particularly relevant for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who experience prolonged post-transplant T cell deficiency caused by cytoreductive ..
  35. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ..Planned in consultation with faculty experts in cell transplantation and regenerative medicine and a professional animal facilities designer, GHARC responds to user needs ..
  36. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ..This is particularly relevan for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who experience prolonged post-transplant T cell deficiency caused by cytoreductive ..
  37. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic bone marrow or hematopoietic stem cell transplantation (allo BMT) is an important therapy with curative potential for a variety of malignant and non-malignant diseases...
  38. Lentiviral-transduced hematopoictic stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..As pre-clinical studies, we will use the mouse model for cystinosis that accumulates cystine in all the tissues and develops similar defects to those of the human children. ..
  39. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..of peripheral T cell tolerance and prevention of graft-versus-host disease (GVHD) after human hematopoietic cell transplantation (HCT)...
  40. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
    ..These cells may be valuable for not only personalized cell transplantation therapy without immune rejection but also for understanding disease mechanisms, drug screening, tissue ..
  41. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2012
    ..to measure the effectiveness of emerging approaches to neuroprotection and myelin repair, such as stem cell transplantation. Ultimately, developing these biomarkers will allow identification of patients who are most likely to ..
  42. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for autoimmune ..
  43. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron overload is common in patients undergoing hematopoietic cell transplantation (HCT) and recent reports show increased non-relapse mortality in patients with iron overload as determined by ..
  44. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ..cytokine mediators of Treg suppression will be investigated using knockout and reporter transgenic mice, cell transplantation experiments, cytokine neutralizing antibodies, and co-culture assays measuring the stimulatory capacity of ..
  45. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel S Greenberger; Fiscal Year: 2010
    ..of antioxidant reserves in the irradiated esophagus by MnSOD-PL treatment, in both ROSA and FYDR marrow cell transplantation models, stabilizes marrow stem cell engraftment...
  46. A cell-specific inducible model of hearing loss
    Albert S Edge; Fiscal Year: 2011
    ..without damage to tissues that surround the dead cells would expedite procedures for cell replacement by cell transplantation or by use of genetic manipulation or therapeutic means of stimulating endogenous cells to replace the lost ..
  47. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
    ..Allogeneic hematopoietic stem cell transplantation is curative, although such a treatment typically requires an HLA-matched donor, is associated with ..
  48. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Autologous hematopoietic stem cell transplantation (HSCT) has been an important treatment option for many patients with hematologic malignancies and solid tumors such as acute myeloid leukemia, ..
  49. Development of Human, Autologous, Pluripotent Very Small Embryonic Like (VSELs) s
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..There is only one intervention that saves a fatally irradiated person - a rescue through stem cell transplantation. The cure rate for this treatment can be high, provided the treatment is delivered within 7-10 days ..
  50. Triplex-mediated DNA repair as a novel therapy for Hurler Syndrome patients
    Elizabeth Peterson-Roth; Fiscal Year: 2012
    ..Alternatively, allogeneic hematopoietic stem cell transplantation (HSCT) represents a highly effective treatment...
  51. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for many patients with hematologic malignancies and other blood disorders...
  52. Transplant Associated Infection Surveillance Network Phase II
    PETER GEORGE PAPPAS; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Organ and hematopoietic stem cell transplantation has become an increasingly important and life saving measure for thousands of persons each year in the ..
  53. Nanoliposome-based Treatment of Amyloid Protein (AL) Toxicity
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2013
    ..Chemotherapy[unreadable]stem cell transplantation, the only treatment available, has high treatment- related mortality and incomplete success rate...
  54. A search for genes that regulate allogeneic stem cell competition
    Irving L Weissman; Fiscal Year: 2013
    ..that may regulate stem cell competition in Botryllus, (ii) investigate the role of selected genes in stem cell transplantation engraftment and competitive repopulation of tissues, and (iii) investigate the potential role of genes ..
  55. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..This proposal will examine whether a PEGylated fibrin patch based stem cell transplantation can provide a new regeneration therapy for heart failure patients.
  56. Targeted Therapies and Mechanisms of Resistance in Chronic Lymphocytic Leukemia
    Jennifer A Woyach; Fiscal Year: 2013
    ..leukemia (CLL) is the most prevalent form of adult leukemia and is currently incurable outside of stem cell transplantation. Fludarabine-based chemoimmunotherapy is standard initial therapy for younger patients with CLL, while the ..
  57. Novel Immunodeficiency caused by TFRC Mutation
    RAIF SALIM GEHA; Fiscal Year: 2013
    ..of cord blood lymphocytes for increased TfR1 surface expression, early intervention with hematopoietic stem cell transplantation (HSCT), and genetic counseling...
  58. TRANSPLANTATION OF TESTIS STEM CELLS IN LARGE ANIMALS
    Ina Dobrinski; Fiscal Year: 2013
    ..isolation and expansion of porcine GSCs;2) to generate pigs carrying a targeted gene deletion through germ cell transplantation;3) to study the effects of the testicular microenvironment on morphogenesis and germ cell differentiation ..
  59. Identification of Stromal Responses During Castration Mediated Thymic Regrowth
    ANN VENABLES GRIFFITH; Fiscal Year: 2011
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for autoimmune ..
  60. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ..remission, or at least a state of minimal-residual disease, are eligible for allogeneic hematopoietic stem-cell transplantation (HSCT)...
  61. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..We have shown that hematopoietic stem cell transplantation (HSCT) can increase C7 protein in skin and mucous membranes, and ameliorate many of the disease ..
  62. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2013
    ..bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell transplantation following high dose chemotherapy...
  63. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is a successful treatment option for many patients with severe hematologic diseases...
  64. Targeting the leukemia microenvironment by CXCR4 inhibition in stem cell transpla
    Marina Y Konopleva; Fiscal Year: 2010
    ..Allogeneic stem cell transplantation is an effective treatment for AML in first remission, with approximately 60% achieving long-term ..
  65. GM-CSF secreting tumor cell vaccines to enhance post-transplant anti-CLL immunity
    Catherine Wu; Fiscal Year: 2009
    ..as demonstrated by observations of the graft-versus-leukemia (GvL) effect after hematopoietic stem cell transplantation and donor lymphocyte infusion (DLI)...
  66. Substrata Interactions of Normal and Leukemic Hematopoietic Stem Cells
    Jane Liesveld; Fiscal Year: 2009
    ..Understanding these interactions would therefore have implications for normal stem cell transplantation and for therapy of various types of leukemias...
  67. OPTIMIZING ALLOGENEIC TRANSPLANTATION USING CXCR4 BLOCKADE
    John F DiPersio; Fiscal Year: 2010
    ..blood has largely replaced bone marrow as a source of stem cells for both autologous and allogeneic stem cell transplantation. Granulocyte Colony Stimulating Factor (G-CSF) with or without chemotherapy has become the standard of care ..
  68. Stem Cell Transplantation for Hemoglobinopathies in Dogs
    JOHN HEARST; Fiscal Year: 2003
    ..the completion of this validation through the support of US Public Health Service Grant R01 HL63456 "Stem Cell Transplantation to Establish AIIochimerism," this project is now entering a development phase that should ultimately lead ..
  69. A Novel Method to Isolate Islet Cells
    JERRY KNOBELOCH; Fiscal Year: 2007
    ..Pancreatic islet cell transplantation has received considerable attention as a procedure with the potential to cure patients with diabetes...
  70. Cord Blood Stem Cell Transplantation, Hemoglobinopathies
    JOHN HEARST; Fiscal Year: 2003
    ..the completion of this validation through the support of US Public Health Service Grant R01 HL63456, "Stem Cell Transplantation to Establish Allochimerism," this project is now entering a development phase that should ultimately lead ..
  71. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    Over the past decade, the use of immune deficient mice as recipients for human hematopoietic stem cell transplantation has dramatically improved stem cell research...
  72. Restoring Hematopoiesis Following Radiation Injury
    Amelia Bartholomew; Fiscal Year: 2005
    ..can be treated with both colony-stimulating factors, aggressive use of anti-microbials, and stem cell transplantation. The strategy involving allogeneic stem cell transplantation, due to the morbidity and mortality associated ..
  73. RAGE Mediated Mechanisms of Islet Amyloid Polypeptide Cytotoxicity in Type 2 Diab
    Andisheh Abedini; Fiscal Year: 2011
    ..There is increasing evidence that islet amyloid formation is an important complicating factor in islet cell transplantation, and we have recently shown that prevention of islet amyloid can contribute significantly to graft survival...
  74. Immune Recovery Following LLME Treated Cell Therapy
    Joanne Filicko; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is the preferred therapy for a variety of disorders...
  75. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence...
  76. Effect of recipient age /graft vs host disease post BMT
    RAYMOND HUTCHISON; Fiscal Year: 2001
    Murine models of hematopoietic stem cell transplantation will be utilized to investigate the association between advancing age and more severe graft-vs.-host disease (GVHD)...
  77. CELLULAR IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCY
    John Levine; Fiscal Year: 2006
    ..The candidate, Dr. John Levine, is a junior faculty member in the Blood and Marrow Stem Cell Transplantation Program at the University of Michigan. Dr...