autologous transplantation

Summary

Summary: Transplantation from another site in or on the body of the individual receiving it.

Top Publications

  1. ncbi Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
    Eriko Tateishi-Yuyama
    Department of Medicine II and Cardiovascular Centre, Kansai Medical University, Osaka, Japan
    Lancet 360:427-35. 2002
  2. pmc Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 113:1701-10. 2004
  3. pmc Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
    Christian Gisselbrecht
    Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Clin Oncol 28:4184-90. 2010
  4. ncbi Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients
    Antonio Palumbo
    Divisione di Ematologia dell Universita di Torino, Azienda Ospedaliero Universitaria San Giovanni Battista, Via Genova 3, 10126 Torino, Italy
    J Clin Oncol 28:800-7. 2010
  5. ncbi Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    J C Banwart
    Section of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, USA
    Spine (Phila Pa 1976) 20:1055-60. 1995
  6. ncbi Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium
    Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    N Engl J Med 351:1187-96. 2004
  7. ncbi Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery
    Timothy A Moseley
    Department of Research and Technology, Division of Biologics, Cytori Therapeutics, Inc, San Diego, CA 92121, USA
    Plast Reconstr Surg 118:121S-128S. 2006
  8. ncbi In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/
    Anthony H Goldstone
    North London Cancer Network, University College London Hospitals, London, United Kingdom
    Blood 111:1827-33. 2008
  9. ncbi Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans
    Koji Miyamoto
    Department of Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circulation 114:2679-84. 2006
  10. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008

Detail Information

Publications262 found, 100 shown here

  1. ncbi Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
    Eriko Tateishi-Yuyama
    Department of Medicine II and Cardiovascular Centre, Kansai Medical University, Osaka, Japan
    Lancet 360:427-35. 2002
    ..We investigated efficacy and safety of autologous implantation of bone marrow-mononuclear cells in patients with ischaemic limbs because of peripheral arterial disease...
  2. pmc Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 113:1701-10. 2004
    ..This study shows that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach...
  3. pmc Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
    Christian Gisselbrecht
    Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Clin Oncol 28:4184-90. 2010
    ..Salvage regimens have never been compared; their efficacy in the rituximab era is unknown...
  4. ncbi Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients
    Antonio Palumbo
    Divisione di Ematologia dell Universita di Torino, Azienda Ospedaliero Universitaria San Giovanni Battista, Via Genova 3, 10126 Torino, Italy
    J Clin Oncol 28:800-7. 2010
    PURPOSE To evaluate the effect of bortezomib as induction therapy before autologous transplantation, followed by lenalidomide as consolidation-maintenance in myeloma patients...
  5. ncbi Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    J C Banwart
    Section of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, USA
    Spine (Phila Pa 1976) 20:1055-60. 1995
    ..The findings suggest that procedural refinements of limiting subcutaneous dissection and providing layered tension-free incision closure may improve results...
  6. ncbi Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium
    Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    N Engl J Med 351:1187-96. 2004
    ..We studied the use of autologous oral mucosal epithelial cells as a source of cells for the reconstruction of the corneal surface...
  7. ncbi Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery
    Timothy A Moseley
    Department of Research and Technology, Division of Biologics, Cytori Therapeutics, Inc, San Diego, CA 92121, USA
    Plast Reconstr Surg 118:121S-128S. 2006
    ....
  8. ncbi In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/
    Anthony H Goldstone
    North London Cancer Network, University College London Hospitals, London, United Kingdom
    Blood 111:1827-33. 2008
    ..the role of allogeneic transplantation for adults with acute lymphoblastic leukemia (ALL) and compare autologous transplantation with standard chemotherapy...
  9. ncbi Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans
    Koji Miyamoto
    Department of Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circulation 114:2679-84. 2006
    ..The purpose of this study was to assess the long-term safety and efficacy of bone marrow mononuclear cell transplantation in patients with thromboangiitis obliterans...
  10. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008
    ..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone defects...
  11. ncbi Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema
    N Shigemura
    Division of Cardiothoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Transplant 6:2592-600. 2006
    ..The goal of this study was to demonstrate the therapeutic impact of autologous transplantation of ASCs through HGF supplementation for the enhancement of alveolar repair in a rat model of emphysema...
  12. ncbi Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation
    Tsutomu Inatomi
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Ophthalmol 141:267-275. 2006
    ..To perform a midterm assessment of the integrity and reproducibility of cultivated autologous oral mucosal epithelial sheets, and to evaluate the clinical efficacy of their transplantation in ocular surface...
  13. pmc Idiotype-pulsed antigen-presenting cells following autologous transplantation for multiple myeloma may be associated with prolonged survival
    Martha Q Lacy
    Division of Hematology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 84:799-802. 2009
    ..This approach warrants further investigation to confirm this and define the role of vaccine therapy in myeloma...
  14. pmc Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis
    J P A Samijn
    Department of Neurology, MS Centre ErasErasmus MC, Postbox 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:46-50. 2006
    ..Certain stem cell transplantation procedures might slow down inflammatory pathology in multiple sclerosis (MS)...
  15. ncbi A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children
    Rimtautas Gudas
    Kaunas University of Medicine, Kaunas, Lithuania
    J Pediatr Orthop 29:741-8. 2009
    The aim of this study was to compare the outcomes of the arthroscopic mosaic-type osteochondral autologous transplantation (OAT) and microfracture (MF) procedures for the treatment of osteochondritis dissecans (OCD) defects of the femoral ..
  16. ncbi Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation
    Iskra Pusic
    Washington University School of Medicine, Siteman Cancer Center, St Louis, Missouri 63110, USA
    Biol Blood Marrow Transplant 14:1045-56. 2008
    ..study we analyzed clinical records of 1834 patients who underwent stem cell mobilization for autologous transplantation from November 1995 to October 2006 at the Washington University in St. Louis...
  17. ncbi Fat grafting to the breast revisited: safety and efficacy
    Sydney R Coleman
    New York University School of Medicine, New York, NY 10013, USA
    Plast Reconstr Surg 119:775-85; discussion 786-7. 2007
    ..As discussions of fat grafting to the breast are surfacing all over the world, it is time to reexamine the opinions of the 1987 American Society of Plastic and Reconstructive Surgeons position paper...
  18. ncbi Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009
    P Ljungman
    Department of Haematology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 45:219-34. 2010
    ..The introduction of alternative therapies, such as imatinib for CML, has challenged well-established indications. An updated report with revised tables and operating definitions is presented...
  19. ncbi Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits
    Chen Fuh Lam
    Department of Anesthesiology, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
    Anesthesiology 108:392-401. 2008
    ..Here, the authors present the first study demonstrating the therapeutic potential of EPCs in a rabbit model of ALI/ARDS...
  20. ncbi A prospective randomized multicenter clinical evaluation of an anterior cervical fusion cage
    R J Hacker
    Oregon Neurosurgery Specialists, Eugene, Oregon 97401, USA
    Spine (Phila Pa 1976) 25:2646-54; discussion 2655. 2000
    ..A prospective, concurrently controlled, randomized, multicenter trial of an anterior Bagby and Kuslich cervical fusion cage (BAK/C; Sulzer Spine-Tech, Minneapolis, MN) for treatment of degenerative disc disease of the cervical spine...
  21. pmc Magnetically labeled mesenchymal stem cells after autologous transplantation into acutely injured liver
    Xiao Lei Shi
    Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No 321 Zhongshan Road, Nanjing, Jiangsu Province, China
    World J Gastroenterol 16:3674-9. 2010
    ..To evaluate tracking of magnetically labeled mesenchymal stem cells (MSCs) after intraportal transplantation...
  22. ncbi Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow
    G I Im
    Hallym University, Chunchon, Korea
    J Bone Joint Surg Br 83:289-94. 2001
    ..These findings suggest that repair of cartilage defects can be enhanced by the implantation of cultured mesenchymal stem cells...
  23. ncbi Structural fat grafting: more than a permanent filler
    Sydney R Coleman
    New York University School of Medicine, New York 10013, USA
    Plast Reconstr Surg 118:108S-120S. 2006
    ..Of particular interest is the research that has pointed to the use of stem cells to repair and even to become bone, cartilage, muscle, blood vessels, nerves, and skin. Further studies are essential to understand grafted fat tissue...
  24. ncbi Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study
    Shmuel Fuchs
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, 110 Irving Street NW, 4B 1, Washington, DC 20010, USA
    J Am Coll Cardiol 41:1721-4. 2003
    ..We conducted a pilot study to evaluate the feasibility of transendocardial delivery of autologous bone marrow (ABM) strategy in patients with severe symptomatic chronic myocardial ischemia not amenable to conventional revascularization...
  25. ncbi Syngeneic hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma: a comparison with allogeneic and autologous transplantation--The Lymphoma Working Committee of the International Bone Marrow Transplant Registry and the European Group for Blood
    Philip J Bierman
    University of Nebraska Medical Center, Omaha, NE 68198 7680, USA
    J Clin Oncol 21:3744-53. 2003
    ..To compare results of syngeneic, allogeneic, and autologous hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma (NHL)...
  26. ncbi Heat-shock proteins and their role in chondrocyte protection, an application for autologous transplantation
    D A Sawatzky
    Experimental Pathology Group, William Harvey Research Institute, Saint Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Charterhouse Square, London, EC1M 6BQ, UK
    Inflammopharmacology 12:569-89. 2005
    ....
  27. ncbi Autologous transplantation of muscle-derived CD133+ stem cells in Duchenne muscle patients
    Y Torrente
    Fondazione IRCCS Ospedale Maggiore Policlinico of Milan, Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Italy
    Cell Transplant 16:563-77. 2007
    ..Here we tested the safety of autologous transplantation of muscle-derived CD133+ cells in eight boys with Duchenne muscular dystrophy in a 7-month, double-blind ..
  28. ncbi Poor mobilization of hematopoietic stem cells-definitions, incidence, risk factors, and impact on outcome of autologous transplantation
    Patrick Wuchter
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Biol Blood Marrow Transplant 16:490-9. 2010
    ..mobilization" (PM), we have analyzed the efficiency of mobilization in patients intended to receive autologous transplantation at our center in the past 6 years...
  29. ncbi Intramuscular autotransplantation of pancreatic islets in a 7-year-old child: a 2-year follow-up
    E Rafael
    Department of Surgery, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Am J Transplant 8:458-62. 2008
    ....
  30. ncbi Autologous transplantation of EPCs encoding FGF1 gene promotes neovascularization in a porcine model of chronic myocardial ischemia
    Shu yan Chen
    Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No 1665 Kong Jiang Road, Shanghai 200092, China
    Int J Cardiol 135:223-32. 2009
    ..fibroblast growth factor (sp-FGF1) gene transfer may achieve functional improvement of EPCs and that autologous transplantation of sp-FGF1-modified EPCs can facilitate neovascularization in a porcine model of chronic myocardial ..
  31. ncbi Second allogeneic transplantation after failure of first autologous transplantation
    J P Radich
    Clinical Research Division of the Fred Hutchinson Cancer Research Center University of Washington School of Medicine, 98109, USA
    Biol Blood Marrow Transplant 6:272-9. 2000
    ..allogeneic bone marrow transplantations (BMTs) in 59 patients aged 1-57 years who relapsed after initial autologous transplantation. Patients received a second transplantation for recurrent acute myeloid leukemia (AML) (n = 24), acute ..
  32. ncbi High dose sequential chemotherapy with autologous transplantation versus dose-dense chemotherapy MegaCEOP as first line treatment in poor-prognosis diffuse large cell lymphoma: an "Intergruppo Italiano Linfomi" randomized trial
    Umberto Vitolo
    Ematologia, Azienda Ospedaliera S Giovanni Battista, Corso Bramante 88, 10126 Turin, Italy
    Haematologica 90:793-801. 2005
    ....
  33. ncbi Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    Nathalie Cartier
    INSERM UMR745, University Paris Descartes, 75279 Paris, France
    Science 326:818-23. 2009
    ..Thus, lentiviral-mediated gene therapy of hematopoietic stem cells can provide clinical benefits in ALD...
  34. ncbi Allogeneic transplantation improves the overall and progression-free survival of Hodgkin lymphoma patients relapsing after autologous transplantation: a retrospective study based on the time of HLA typing and donor availability
    Barbara Sarina
    Hematology Department, Istituto Clinico Humanitas, Milano, Italy
    Blood 115:3671-7. 2010
    Hodgkin lymphoma relapsing after autologous transplantation (autoSCT) has a dismal outcome. Allogeneic transplantation (alloSCT) using reduced intensity conditioning (RIC) is a salvage option, but its effectiveness is still unclear...
  35. ncbi Autologous bone marrow-derived mononuclear cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction
    Hon Kan Yip
    Division of Cardiology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Circ J 72:1336-45. 2008
    ..We examined the effects of bone marrow-derived mononuclear cells (BMDMNCs) on preventing viable myocardium damage from myocardial infarction (MI) in a rat MI model...
  36. ncbi Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells
    Vishnu Motukuru
    Jain Institute of Vascular Sciences, Bhagawan Mahaveer Jain Hospital, Bangalore, India
    J Vasc Surg 48:53S-60S; discussion 60S. 2008
    ..We have reviewed our series of patients who underwent autologous bone marrow mononuclear cell transplantation during the last 2 years...
  37. ncbi Short-term heart retention and distribution of intramyocardial delivered mesenchymal cells within necrotic or intact myocardium
    Nguyen Tran
    Laboratory of Surgery School, Faculty of Medicine Nancy, avenue de la Forêt de Haye, BPl84, 54505 Vandoeuvre Les Nancy Cedex, France
    Cell Transplant 15:351-8. 2006
    ..BMSCs have a higher retention when they are injected in necrotic than in normal myocardial areas and these cells appear to stay around the injection site for at least a 7-day period...
  38. ncbi Safety analysis and improved cardiac function following local autologous transplantation of CD133(+) enriched bone marrow cells after myocardial infarction
    Hossein Ahmadi
    Tehran Heart Center, Tehran University of Medical Sciences, Tehran, I R Iran
    Curr Neurovasc Res 4:153-60. 2007
    ..Moreover, these cells might restore tissue viability and improve perfusion of the infarcted myocardium, suggesting that they may induce myogenesis as well as angiogenesis...
  39. ncbi The morbidity associated with osteochondral harvest from asymptomatic knees for the treatment of osteochondral lesions of the talus
    Sudheer Reddy
    Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Sports Med 35:80-5. 2007
    ..Mosaic autogenous osteochondral transplantation has been used to treat large osteochondral defects...
  40. ncbi Molecular remission after allogeneic or autologous transplantation of hematopoietic stem cells for multiple myeloma
    G Martinelli
    Institute of Hematology and Medical Oncology Seragnoli, University of Bologna, Italy
    J Clin Oncol 18:2273-81. 2000
    ....
  41. ncbi Early autologous stem-cell transplantation versus conventional chemotherapy as front-line therapy in high-risk, aggressive non-Hodgkin's lymphoma: an Italian multicenter randomized trial
    Maurizio Martelli
    Department of Cellular Biotechnology and Hematology, University La Sapienza of Rome, Italy
    J Clin Oncol 21:1255-62. 2003
    ..To evaluate the role of early intensification with high-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) as front-line chemotherapy for patients with high-risk, histologically aggressive non-Hodgkin's lymphoma (NHL)...
  42. ncbi Single versus double autologous stem-cell transplantation for multiple myeloma
    Michel Attal
    Department of Hematology and Biostatistics, Hopital Purpan, Toulouse, France
    N Engl J Med 349:2495-502. 2003
    ..We conducted a randomized trial of the treatment of multiple myeloma with high-dose chemotherapy followed by either one or two successive autologous stem-cell transplantations...
  43. ncbi Prospective nonrandomized comparison of an allograft with bone morphogenic protein versus an iliac-crest autograft in anterior cervical discectomy and fusion
    Glenn Robin Buttermann
    Midwest Spine Institute Stillwater, Spine Surgery Division, 1950 Curve Crest Blvd, Stillwater, MN 55115, USA
    Spine J 8:426-35. 2008
    ..This has led some surgeons to use alternatives to iliac bone graft, but often the alternatives have greater rates of nonunion and delayed union. Bone morphogenic protein (BMP) studies have found high arthrodesis rates in lumbar fusions...
  44. ncbi Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life
    Riccardo Saccardi
    Bone Marrow Transplantation Unit, Careggi Hospital, University of Florence, Italy
    Blood 105:2601-7. 2005
    ..HSCT is able to induce a prolonged clinical stabilization in severe progressive MS patients, resulting in both sustained treatment-free periods and quality of life improvement...
  45. ncbi Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens
    Richard K Burt
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
    Arthritis Rheum 54:3750-60. 2006
  46. ncbi A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years
    Gunnar Knutsen
    Department of Orthopaedic Surgery, University of Tromsø, University Hospital North Norway, 9038 Tromsø, Norway
    J Bone Joint Surg Am 89:2105-12. 2007
    ..The objective of this randomized trial was to compare autologous chondrocyte implantation with microfracture. This paper represents an update, with presentation of the clinical results at five years...
  47. ncbi Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Waehringer, Austria
    Eur J Radiol 57:16-23. 2006
    ..High resolution MRI and well-defined MRI variables are a reliable, reproducible and accurate tool for assessing cartilage repair tissue...
  48. pmc Yttrium-90 ibritumomab tiuxetan doses calculated to deliver up to 15 Gy to critical organs may be safely combined with high-dose BEAM and autologous transplantation in relapsed or refractory B-cell non-Hodgkin's lymphoma
    Jane N Winter
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Oncol 27:1653-9. 2009
    ..radiation-absorbed dose (RAD) to critical organs delivered by yttrium-90 ((90)Y) ibritumomab tiuxetan in combination with high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) chemotherapy with autologous transplantation.
  49. ncbi Complete remission status before autologous stem cell transplantation is an important prognostic factor in patients with multiple myeloma undergoing upfront single autologous transplantation
    Jin Seok Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Biol Blood Marrow Transplant 15:463-70. 2009
    ..Our findings suggest that the development of more effective induction regimens, including novel antimyeloma agents to improve initial response, should be pursued to enhance clinical benefits post-ASCT...
  50. pmc Treatment of focal articular cartilage defects in the knee: a systematic review
    Robert A Magnussen
    Vanderbilt Orthopaedic Institute, 4200 Medical Center East, 1215 21st Avenue South, Suite 4200, Nashville, TN, 37232 8774, USA
    Clin Orthop Relat Res 466:952-62. 2008
    ..A large prospective trial investigating these techniques with the addition of a control group would be the best way to definitively address the clinical questions...
  51. ncbi Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells
    R J Tsai
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    N Engl J Med 343:86-93. 2000
    ..However, this procedure requires a large limbal graft from the healthy eye and is not possible in patients who have bilateral lesions...
  52. doi Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma
    Philippe Moreau
    Blood 112:3914-5. 2008
  53. ncbi CD34+ selected autologous peripheral blood stem cell transplantation for multiple sclerosis: report of toxicity and treatment results at one year of follow-up in 15 patients
    Enric Carreras
    BMT Unit, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Haematologica 88:306-14. 2003
    ..We report the results of a phase II trial to evaluate feasibility and toxicity of CD34+ selected ASCT (CD34+/ASCT) and treatment results at one year of follow-up...
  54. ncbi Arthroscopic autologous chondrocyte transplantation: technical note
    M Marcacci
    Laboratorio di Biomeccanica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 10:154-9. 2002
    ..The procedure includes the advantages of arthroscopic osteochondral grafting without donor site morbidity. With this technique is possible to reduce the patient morbidity, time and cost of surgery...
  55. ncbi Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe
    P Ljungman
    Department of Hematology, Karolinska University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 37:439-49. 2006
    ..The introduction of alternative therapies has challenged well-established indications such as imatinib for chronic myeloid leukaemia. An updated report with revised tables and operating definitions is presented here...
  56. ncbi Treatment of multiple myeloma
    Bart Barlogie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 103:20-32. 2004
    ..Fundamental and clinical research should, therefore, focus on the molecular and biologic mechanisms of treatment failure in the high-risk subgroup...
  57. ncbi Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial
    Gunnar Knutsen
    Department of Orthopaedic Surgery, University Hospital Tromsø, 9038 Tromsø, Norway
    J Bone Joint Surg Am 86:455-64. 2004
    ..The objective of the present study was to compare autologous chondrocyte implantation with microfracture in a randomized trial. We are not aware of any previous randomized studies comparing these methods...
  58. ncbi Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture, and osteochondral autograft transplantation
    Alberto Gobbi
    Orthopaedic Arthroscopic Surgery International, Milan, Italy
    Arthroscopy 22:1085-92. 2006
    The purpose of this study was to compare outcomes of chondroplasty versus microfracture versus osteochondral autologous transplantation (OAT) in patients with osteochondral lesions of the talus (OLT).
  59. ncbi In vivo magnetic resonance tracking of Feridex-labeled bone marrow-derived neural stem cells after autologous transplantation in rhesus monkey
    Yi quan Ke
    Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China
    J Neurosci Methods 179:45-50. 2009
    ..These results suggest that Feridex labeling of BMSCs-D-NSCs is feasible, efficient and safe for MRI tracing following autografting into the rhesus monkey nervous system...
  60. ncbi Autologous transplantation in elderly patients with multiple myeloma: are we asking the right questions?
    H D Klepin
    Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone Marrow Transplant 38:585-92. 2006
    ..Traditional upper age limits for autologous transplantation are being challenged along with the definition of 'elderly' itself...
  61. ncbi Long-term outcomes of autologous transplantation in multiple myeloma: significant survival benefit of novel drugs in post-transplantation relapse
    Marta Krejci
    Department of Internal Medicine Hematooncology, Masaryk University Hospital, Jihlavska 20, 625 00 Brno, Czech Republic
    Clin Lymphoma Myeloma 9:436-42. 2009
    ..Treatment options for myeloma have expanded in the past decade, and it seems that patients who are treated with novel drugs such as thalidomide and bortezomib for relapse after autoSCT have longer overall survival (OS)...
  62. ncbi Infections after CD34-selected or unmanipulated autologous hematopoietic stem cell transplantation
    Pascale Frère
    Division of Hematology, Department of Medicine, University of Liege, Liege, Belgium
    Eur J Haematol 76:102-8. 2006
    ..The role of extended infection prophylaxis should be evaluated...
  63. ncbi Ovarian tissue autologous transplantation to the upper extremity for girls receiving abdominal/pelvic radiation: 20-year follow-up of reproductive endocrine function
    Marc R Laufer
    Division of Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Pediatr Adolesc Gynecol 23:107-10. 2010
    Upper-extremity ovarian autologous transplantation was first used for girls undergoing abdominal/pelvic radiation therapy; long-term follow-up is provided.
  64. ncbi [Voluminous bone graft harvesting of the femoral marrow cavity for autologous transplantation. An indication for the"Reamer-Irrigator-Aspirator-" (RIA-)technique]
    P Kobbe
    Department of Orthopaedic Surgery, Kaufmann Medical Building, University of Pittsburgh, 3471 Fifth Avenue, Suite 1010, Pittsburgh, PA 15213, USA
    Unfallchirurg 111:469-72. 2008
    ..The contralateral femur was reamed and the bone graft was applied to the nonunion. The patient showed clinical and radiological healing of the nonunion without donor site complications...
  65. ncbi Autologous transplantation of adult adipose derived stem cells into rabbit urethral wall
    Fernando Goncalves Almeida
    Department of Urology, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
    Int Urogynecol J 21:743-8. 2010
    ..A study was carried out to evaluate the feasibility of autologous adipose derived stem cells (ADSC) transplantation into female rabbits' urethra walls as an alternative to intrinsic urethral regeneration...
  66. ncbi Evidence for naive T-cell repopulation despite thymus irradiation after autologous transplantation in adults with multiple myeloma: role of ex vivo CD34+ selection and age
    Marion Malphettes
    Laboratoire d Immunologie Cellulaire et Tissulaire URA CNRS 625, Hopital de la Pitie Salpetriere, Paris, France
    Blood 101:1891-7. 2003
    ..randomly assigned to receive high-dose therapy including total body irradiation (TBI) followed by autologous transplantation with either unselected or CD34+-selected PBSCs...
  67. ncbi Livebirth after orthotopic transplantation of cryopreserved ovarian tissue
    J Donnez
    Department of Gynaecology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, B 1200, Brussels, Belgium
    Lancet 364:1405-10. 2004
    ..In 1997, biopsy samples of ovarian cortex were taken from a woman with stage IV Hodgkin's lymphoma and cryopreserved before chemotherapy was initiated. After her cancer treatment, the patient had premature ovarian failure...
  68. ncbi Cartilage restoration, part 1: basic science, historical perspective, patient evaluation, and treatment options
    J Winslow Alford
    Shoulder and Sports Medicine Division, West Bay Orthopedics, Warwick, Rhode Island, USA
    Am J Sports Med 33:295-306. 2005
    ..In this article (part 1), the authors review the basic science of chondral injuries, the historical perspective of the available surgical options, and present guidelines for patient evaluation and treatment...
  69. ncbi Three-, 6-, and 12-month results of autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction
    Jaroslav Meluzin
    1st Department of Internal Medicine Cardioangiology, St Anna Hosp, MU Czech Republic
    Int J Cardiol 128:185-92. 2008
    ..There are only few data on long-term effectiveness of the stem cell therapy...
  70. ncbi Outcome of autologous transplantation for mantle cell lymphoma: a study by the European Blood and Bone Marrow Transplant and Autologous Blood and Marrow Transplant Registries
    Elisabeth Vandenberghe
    Department of Haematology, St James Hospital, Dublin, Ireland
    Br J Haematol 120:793-800. 2003
    ..99 times (95% CI: 1.66-5.38, P < 0.001) more likely to die than patients transplanted in CR1. Autologous transplantation probably improves survival in patients with MCL especially if performed in first CR.
  71. ncbi Autologous transplantation of porcine myogenic precursor cells in skeletal muscle
    Nicolas Holzer
    Department of Clinical Neurosciences and Dermatology, Geneva Faculty of Medicine and University Hospital, Geneva, Switzerland
    Neuromuscul Disord 15:237-44. 2005
    ..b>Autologous transplantation of 3[H]-thymidine labeled porcine myogenic precursor cells indicated 60% survival at day 1 followed by a ..
  72. ncbi Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer
    B W Cooper
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 16:3509-17. 1998
    ..To determine whether occult tumor contamination of autologous bone marrow or peripheral-blood progenitor cells (PBPC) influences clinical outcome after high-dose chemotherapy in patients with stage IV breast cancer...
  73. ncbi Plerixafor (Mozobil) alone to mobilize hematopoietic stem cells from multiple myeloma patients for autologous transplantation
    Neal Flomenberg
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Biol Blood Marrow Transplant 16:695-700. 2010
    ..Further research into single agent use should focus on alternate route of administration as well as adjustment of the timing of the apheresis to improve cell HSC yield...
  74. ncbi Peripheral blood stem cell mobilization by granulocyte colony-stimulating factor alone and engraftment kinetics following autologous transplantation in children and adolescents with solid tumor
    H Watanabe
    Department of Pediatrics, University of Tokushima Graduate School of Medical Science, Tokushima, Japan
    Bone Marrow Transplant 37:661-8. 2006
    ....
  75. ncbi Human islet isolation for autologous transplantation: comparison of yield and function using SERVA/Nordmark versus Roche enzymes
    T Anazawa
    Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 9:2383-91. 2009
    ..The SN and LH enzymes are associated with similar outcomes for IAT. Further optimization of the collagenase/neutral protease ratio is necessary to reduce the number of embedded islets obtained when using the SN enzyme...
  76. ncbi Impact of chromosome 13 deletion and plasma cell load on long-term survival of patients with multiple myeloma undergoing autologous transplantation
    Esbjörn Paul
    Hematology Center, Karolinska University Hospital and Division of Hematology, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Oncol Rep 22:137-42. 2009
    ..020), whereas the plasma cell load had no effect on survival of patients with del(13). Overall, the absence of del(13) in combination with low plasma cell infiltration at diagnosis predicts the best survival...
  77. ncbi Autologous transplantation of bone marrow mononuclear stem cells by mini-thoracotomy in dilated cardiomyopathy: technique and early results
    Renato Abdala Karam Kalil
    Instituto de Cardiologia do Rio Grande do Sul, Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, Brazil
    Sao Paulo Med J 126:75-81. 2008
    ..This study describes a novel technique of BMMC transplantation and the results up to one year after the procedure...
  78. ncbi Randomized comparison of granulocyte colony-stimulating factor versus granulocyte-macrophage colony-stimulating factor plus intensive chemotherapy for peripheral blood stem cell mobilization and autologous transplantation in multiple myeloma
    Mukta Arora
    Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 10:395-404. 2004
    ..colony-stimulating factor (GM-CSF) for peripheral blood stem cell mobilization followed by autologous transplantation. The major study end points were the comparative utility of G-CSF versus GM-CSF, the percentage of ..
  79. ncbi Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients
    Bekele Afessa
    Department of Medicine, Divisions of Pulmonary and Critical Care Medicine and Hematology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 166:1364-8. 2002
    ..This study shows that survival rate of hematopoietic stem cell transplant recipients with diffuse alveolar hemorrhage is better than previously reported, and that early onset and autologous transplant are favorable prognostic indicators...
  80. ncbi Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction
    Volker Schachinger
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1210-21. 2006
    ..Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction...
  81. ncbi Pilot trial of autologous dendritic cells loaded with tumor lysate(s) from allogeneic tumor cell lines in patients with metastatic medullary thyroid carcinoma
    Thomas Bachleitner-Hofmann
    Department of Surgery, Medical University of Vienna, A 1090 Vienna, Austria
    Oncol Rep 21:1585-92. 2009
    ..Combined treatment with different tumor cell lysate-pulsed DCs increases the likelihood of a calcitonin tumor marker response and should therefore be preferred over monotherapy with DCs pulsed with a single lysate...
  82. ncbi Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit
    Yuntao Hu
    Peking University Eye Center, Peking University Third Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 49:3185-92. 2008
    ..An improved translocation technique for autologous retinal pigment epithelium (RPE) transplantation is presented. The graft consists of a sheet of a partial-thickness choroid with RPE attached...
  83. ncbi Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    Circulation 107:2294-302. 2003
    ....
  84. ncbi Cryopreservation of human brain tissue allowing timely production of viable adult human brain cells for autologous transplantation
    Jean Francois Brunet
    Department of Neurosurgery of Lausanne and Geneva University Medical School, Bugnon 46, 1011, Lausanne, Switzerland
    Cryobiology 47:179-83. 2003
    b>Autologous transplantation is an attractive approach to treat some neurological diseases. A major obstacle is the capacity to produce cells for transplantation at the appropriate time...
  85. ncbi Photoreceptors repair by autologous transplantation of retinal pigment epithelium and partial-thickness choroid graft in rabbits
    Taoran Zhang
    Peking University Eye Center, Peking University Third Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 50:2982-8. 2009
    ..To investigate whether autologous retinal pigment epithelium (RPE) and a partial-thickness graft can repair degenerated photoreceptors overlying a mechanically damaged Bruch's membrane...
  86. ncbi Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors
    Sharon L Gardner
    Department of Pediatrics, New York University, New York, New York 10016, USA
    Pediatr Blood Cancer 51:235-40. 2008
    ..Historically, surgery and standard dose chemotherapy have resulted in a median survival of 8.5 months from diagnosis...
  87. ncbi Long-term outcome of autologous transplantation of peripheral blood progenitor cells as postremission management of patients > or =60 years with acute myelogenous leukemia
    Ashkan Lashkari
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Blood Marrow Transplant 12:466-71. 2006
    ..To better understand the long-term outcome of autologous transplantation in AML patients > or =60 years of age, we evaluated high-dose chemoradiotherapy preparative conditioning ..
  88. pmc A comparison of HLA-identical sibling allogeneic versus autologous transplantation for diffuse large B cell lymphoma: a report from the CIBMTR
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 16:35-45. 2010
    ....
  89. ncbi Shortened first-line high-dose chemotherapy for patients with poor-prognosis aggressive lymphoma
    Christian Gisselbrecht
    Institut d Hematologie, GELA Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    J Clin Oncol 20:2472-9. 2002
    ....
  90. pmc Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells
    Xueyi Yang
    Department of Life Sciences, Luoyang Normal University, Luoyang, China
    Mol Vis 14:1064-70. 2008
    ..Here, we report a new strategy for reconstructing the damaged corneal surface in a goat model of total limbal stem cell deficiency (LSCD) by autologous transplantation of epidermal adult stem cells (EpiASC).
  91. ncbi Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector
    Naoki Yokoo
    Department of Orthopaedic Surgery, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Arthritis Rheum 52:164-70. 2005
    ..To examine the effects of basic fibroblast growth factor (bFGF) gene-transduced chondrocytes on the repair of articular cartilage defects...
  92. ncbi Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction
    Yao Liang Tang
    Department of Physiology and Biophysics, College of Medicine, University of South Florida, St Petersburg, Florida, USA
    Ann Thorac Surg 80:229-36; discussion 236-7. 2005
    ..We hypothesize that transplantation of MSCs enhances vascular regeneration through a paracrine action...
  93. ncbi Prolonged remission of neuro-Behcet disease following autologous transplantation
    A De Cata
    Department of Internal Medicine, IRCCS, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Int J Immunopathol Pharmacol 20:91-6. 2007
    ..Immune ablation followed by APBSCT can modify the course of severe N-BD. Because of the high risk and the transplant-related mortality, these cases have to be carefully selected...
  94. pmc Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells
    Yoo Jin Kim
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health NIH, Bethesda, MD 20852, USA
    Blood 113:5434-43. 2009
    ....
  95. ncbi Efficacy of autologous transplantation of noncultured epidermal suspension in two different dilutions in the treatment of vitiligo
    Geeta R Tegta
    Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Dermatol 45:106-10. 2006
    ....
  96. ncbi Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma
    Ashkan Lashkari
    City of Hope Comprehensive Cancer Center, Division of Medical Oncology, 1500 E Duarte Road, Duarte, CA 91010, USA
    Anticancer Res 29:3281-8. 2009
    ..The purpose of our phase II study was to assess the feasibility, safety and efficacy of tandem high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) in such patients...
  97. pmc Controversies in the treatment of lymphoma with autologous transplantation
    Alison J Moskowitz
    Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Oncologist 14:921-9. 2009
    ....
  98. ncbi Artificial niches for human adult neural stem cells: possibility for autologous transplantation therapy
    Charles Y Liu
    Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    J Hematother Stem Cell Res 12:689-99. 2003
    ..the clinical perspective and summarizes ongoing work aimed at exploring the intriguing possibility of autologous transplantation, whereby neural stem cells can be harvested from adult patients, expanded or modified in vitro in ..
  99. ncbi Progressive disease following autologous transplantation in patients with chemosensitive relapsed or primary refractory Hodgkin's disease or aggressive non-Hodgkin's lymphoma
    T Kewalramani
    Department of Medicine, Lymphoma and Hematology Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Bone Marrow Transplant 32:673-9. 2003
    ....
  100. ncbi Quality of life assessment in patients undergoing reduced intensity conditioning allogeneic as compared to autologous transplantation: results of a prospective study
    M Diez-Campelo
    Servicio de Hematologia, Hospital Universitario de Salamanca, Paseo de San Vicente, S N, 37007 Salamanca, Spain
    Bone Marrow Transplant 34:729-38. 2004
    ..We have observed similar QOL among patients undergoing RIC-allo as compared to ASCT although GVHD remains an important 'event' in QOL...
  101. ncbi BEAM allogeneic transplantation for patients with Hodgkin's disease who relapse after autologous transplantation is safe and effective
    Julian P Cooney
    BMT Program, Loyola University Medical Center, Maywood, Illinois, USA
    Biol Blood Marrow Transplant 9:177-82. 2003
    Because few patients failing autologous transplantation for Hodgkin's disease survive long-term, we explored reduced-intensity allografts using BEAM conditioning and early withdrawal of immunosuppression as an alternative to palliative ..

Research Grants62

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..Transplantation of PRDM16 expressing fibroblasts. The goal is to develop an autologous transplantation protocol using PRDM16-expressing precursor cells to form ectopic deposits of functional brown adipose ..
  2. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..PAP in GM-R[unreadable]KO mice was 'cured'by the applicant by autologous transplantation of bone marrow after retrovirus-mediated gene transduction to correct GM-R function...
  3. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..CD34+ stem cells from SCA patients and sustain an improved sickle phenotype after reduced intensity autologous transplantation of the gene-modified HSCs...
  4. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..First, MSCs can be easily isolated, cultured, and propagated as a source of adult stem cells for autologous transplantation, inciting minimal host immune response...
  5. Histone proline isomerization and gene regulation
    Nobuaki Kikyo; Fiscal Year: 2010
    ..This project potentially leads to efficient preparation of patients-derived new tissues for autologous transplantation, complementing the recently reported iPS cell technology...
  6. Keratin Gene Targeting for the Treatment of Epidermolysis Bullosa
    Daniel G Miller; Fiscal Year: 2013
    ..We propose to correct the phenotype of EBS-patient keratinocytes and prepare them for autologous transplantation by using a gene targeting approach...
  7. iPS cells-derived progenitor cells for angiomyogenesis
    Yigang Wang; Fiscal Year: 2013
    ..Such an approach could eventually be used in humans and would allow autologous transplantation, thereby eliminating the problem of host rejection...
  8. Histone isomerization and pluripotency
    Nobuaki Kikyo; Fiscal Year: 2013
    ..This project i expected to lead to efficient preparation of patients-derived new tissues for autologous transplantation, complementing the induced pluripotent stem (iPS) cell technology...
  9. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..These stem cells will be used to generate neo-islets for autologous transplantation into the corresponding offspring...
  10. Elastogenic Factor Functionalized Electrospun Scaffolds for in vivo Generation of
    CHRISTOPHER A BASHUR; Fiscal Year: 2013
    ..Aim 2C will determine graft patency through autologous transplantation in a rat aorta...
  11. De-Cellularized Human Lungs for Ex Vivo Lung Regeneration
    Daniel J Weiss; Fiscal Year: 2012
    ..induced pluripotent stem cells (iPS), derived from individual patients and subsequently utilized for autologous transplantation. Notably, the de-cellularization process removes cellular antigens responsible for immune rejection and ..
  12. OPTIMIZING SPERMATOGONIAL TRANSPLANTATION FOR FERTILITY PRESERVATION
    Gunapala Shetty; Fiscal Year: 2010
    ..In such cases cryopreservation of spermatogonia and autologous transplantation is the only a potential method for restoring spermatogenesis and possibly rescuing fertility...
  13. Bone Marrow Stem Cells: Novel Treatment of Human Glioma
    Frederick F Lang; Fiscal Year: 2010
    ..Additionally, to better mimic autologous transplantation, the capacity of mMSCs to survive within and outside gliomas will be explored in syngeneic, ..
  14. Alveolar Bone Marrow Derived Stem Cells for Clinical Cell Therapy
    Darnell Kaigler; Fiscal Year: 2013
    ..Finally, in SA3, following autologous transplantation of aBMSCs into human craniofacial bone defects, we will determine how the phenotypic characteristics of ..
  15. Neurorestorative therapy of stroke with HUCBC in T2DM rats
    Jieli Chen; Fiscal Year: 2013
    ..HUCBCs can be used for autologous transplantation or allogeneic transplantation, when and if needed...
  16. Engineered Stem Cells for Inner Ear Pharmacotherapy
    Larry F Hoffman; Fiscal Year: 2012
    ..adipose-derived stem cells ASCs, harvested from chinchillas (resulting in chASCs), that can be used for autologous transplantation for the delivery of trophins directly to the inner ear...
  17. Bioengineering New Lungs from Cadaveric Lung Scaffolds
    Daniel J Weiss; Fiscal Year: 2010
    ..induced pluripotent stem cells (iPS) derived from individual patients and subsequently utilized for autologous transplantation. Notably, the de-cellularization process removes cellular antigens responsible for immune rejection and ..
  18. Engraftment and in vivo selection of HIV-protected stem cells
    Ann E Woolfrey; Fiscal Year: 2013
    ..Thus, we would like to test this strategy in a patient population that has been shown to benefit from an autologous transplantation and that may also benefit from both the anti-tumor effect of low-dose chemotherapy used for in vivo ..
  19. Mesenchymal stem cells in the treatment of hindlimb ischemia in diabetic mice
    LOUIS MICHAEL MESSINA; Fiscal Year: 2013
    ..b>Autologous transplantation with mesenchymal stem cells (MSC), a pluripotent cell that par- ticipates in post-ischemic ..
  20. Derivation of Porcine iPS Cells and iPS Cell-Derived Cardiomyocytes
    Joseph C Wu; Fiscal Year: 2010
    ..However, it is critical to validate iPS cells'in vivo behavior and fate after autologous transplantation in pre-clinical large animal models before their safe clinical application becomes possible...
  21. Stem Cell Transplantation for Treatment of Autoimmune Diseases
    Keith M Sullivan; Fiscal Year: 2011
    ..Study of High-Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic ..
  22. Stem Cell Transplantation for Treatment of Autoimmune Diseases
    Keith Sullivan; Fiscal Year: 2010
    ..Study of High-Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic ..
  23. ICE-FREE PRESERVATION OF OVARIES FOR LONG-TERM FECUNDITY
    Ying Song; Fiscal Year: 2004
    ..Cryopreservation of ovarian tissue prior to initiation of cancer therapy, followed by autologous transplantation or in vitro maturation and in vitro fertilization after remission, could provide a means of protecting ..
  24. A Novel Antibody Therapeutic for Multiple Myeloma
    Koteswara Chintalacharuvu; Fiscal Year: 2009
    ..in vitro purging of myeloma cells during ex vivo expansion of hematopoietic progenitor-cells for use in autologous transplantation in multiple myeloma patients...
  25. Anti-TfR IgG3-Av: A New Drug Against Multiple Myeloma
    MANUEL PENICHET; Fiscal Year: 2009
    ..efficient purging of myeloma cells during ex vivo expansion of hematopoietic progenitor-cells for use in autologous transplantation in MM patients...
  26. Preclinical Development of Bone Marrow Mononuclear Cell Therapy for Ischemic Stro
    Sean Savitz; Fiscal Year: 2009
    ..derived from a patient's own marrow and therefore represent an attractive therapeutic approach for autologous transplantation. This proposal therefore seeks to address key translational steps for the development of autologous bone ..
  27. ALLOGENEIC LEUKOCYTE INFUSIONS FOR BREAST CANCER
    SCOTT BEARMAN; Fiscal Year: 2000
    ..the feasibility of administering allogeneic leukocytes to breast cancer patients who have relapsed after autologous transplantation. There are considerable data supporting a graft-versus-tumor effect in selected hematologic malignancies ..
  28. Symposium- Advances in Stem Cell Transplantation
    Edward Ball; Fiscal Year: 2003
    ..myeloablative transplants may permit innovative approaches to stem cell transplantation including tandem autologous transplantation to achieve cytoreduction followed by non-myeloablative allogeneic transplants to achieve the ..
  29. SCLERODERMA CYCLOPHOSPHAMIDE OR TRANSPLANTION STUDY (SCOT)
    Keith Sullivan; Fiscal Year: 2013
    ..Study of High-Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic ..
  30. SCLERODERMA CYCLOPHOSPHAMIDE OR TRANSPLANTION STUDY (SCOT)
    Keith M Sullivan; Fiscal Year: 2012
    ..Study of High-Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic ..
  31. SCLERODERMA CYCLOPHOSPHAMIDE OR TRANSPLANTION STUDY (SCOT)
    Keith M Sullivan; Fiscal Year: 2011
    ..Study of High-Dose Immunosuppressive Therapy Using Total Body Irradiation, Cyclophosphamide, ATGAM, and Autologous Transplantation with Auto-CD34+HPC versus Intravenous Pulse Cyclophosphamide for the Treatment of Severe Systemic ..
  32. CORD BLOOD COLLECTION DEVICE
    RICHARD MEYST; Fiscal Year: 2000
    ..Collection of these cells at birth and subsequent cryopreservation will allow autologous transplantation at any time in an individuals lifetime...
  33. LENTIVIRAL VECTOR TRANSFER TO HEMATOPOIETIC STEM CELLS
    Donald Kohn; Fiscal Year: 2005
    ..genes will be able to effectively transduce HSC and these HSC will have augmented engraftment in autologous transplantation using an optimal cytoreductive dosage of busulfan...
  34. AAV-mediated gene therapy for metabolic bone disease
    Selvarangan Ponnazhagan; Fiscal Year: 2009
    ..Thus, we hypothesize that autologous transplantation of culture-expanded MSC, transduced with rAAV encoding BMP-2 under the control of osteoprogenitor-..
  35. A NOVEL APPROACH TO GERM-LIINE PRESERVATION IN MACAQUES
    Stuart Meyers; Fiscal Year: 2004
    ..Isolation of spermatogonial stem cells before and autologous transplantation after treatment could be an efficient technique to reverse infertility...
  36. Neuroreplacement strategies by mesenchymal stem cell
    Kiminobu Sugaya; Fiscal Year: 2007
    ..material as an alternative to fetal neural tissue, the ideal replacement therapies would be the autologous transplantation. Since we have succeeded in producing neural cells from human mesenchymal stem cells (HMeSCs}, we ..
  37. Bone Marrow-Derived Stem Cell Transplantation to Retina
    STEVEN MCLOON; Fiscal Year: 2005
    ..These cells can differentiate into neurons. They are readily available, and if used for autologous transplantation to the retina, they would not have the same immunological consequences inherent in the use of other cell ..
  38. PERIPHERAL BLOOD STEM CELL MEDIATED GENE TRANSFER
    Steven Greenberg; Fiscal Year: 2001
    ..g. astrocytes or neural stem cells in autologous transplantation studies suffer from the unavoidable requisite neurosurgical procedure to obtain the brain-derived cells...
  39. Adult Stem Cells in the Inner Ear
    Eri Hashino; Fiscal Year: 2005
    ..pool of pluripotent stem cells is easy to isolate, provides a renewal population and can be used for autologous transplantation. Marrow stromal cells have been shown to differentiate into neuronal cells in the central and peripheral ..
  40. Adult Stem Cells in the Inner Ear
    Eri Hashino; Fiscal Year: 2009
    ..pool of pluripotent stem cells is easy to isolate, provides a renewal population and can be used for autologous transplantation. Marrow stromal cells have been shown to differentiate into neuronal cells in the central and peripheral ..
  41. PROGNOSTIC & THERAPEUTIC ROLE OF C-KIT IN BREAST CANCER
    Briana Williams; Fiscal Year: 1999
    ..micrometastasis; (b) response to high dose chemotherapy and therefore a potential marker for response to autologous transplantation therapy. Two databases will be used...
  42. Mechanisms of in vivo protection from HIV infection
    Harris Goldstein; Fiscal Year: 2010
    ..recipient's Class I HLA that will induce differentiation into effective HIV-1-specific CTLs after autologous transplantation. Specifically we will examine whether functional HIV-specific CD8+ CTLs can be generated by delivering ..
  43. Neurogenic Potential of Progenitor Cells in Adipose
    MALU TANSEY; Fiscal Year: 2006
    ..need to be identified and if found in adult peripheral tissues these could be proliferated and used for autologous transplantation. An easily accessible and ample source of progenitor cell with neural characteristics resides in adult ..
  44. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    XILMA ORTIZ GONZALEZ; Fiscal Year: 2005
    ..source for neural transplantation tissue that besides the advantage of being amenable to expansion, differentiation and genetic manipulation in vitro, also embodies the unique prospect for autologous transplantation.
  45. Acquisition of FACSVantage SE Flow Cytometer
    Yair Gazitt; Fiscal Year: 2004
    ..The new equipment will also widen the user's base, save sort time, reduce costs for users and will render sorting affordable to new users, especially in cases where low frequency (<1%) cell populations are sorted. ..
  46. DLI using genetically modified T cells: Phase 1 trial
    John Dipersio; Fiscal Year: 2005
    ..abstract_text> ..
  47. CARDINAL BERNARDIN CANCER CENTER, LOYOLA UNIVERSITY
    Patrick Stiff; Fiscal Year: 2002
    ..At the completion of this grant, the Cardinal Bernardin Cancer Center plans to be positioned to successfully apply for a P-30 Cancer Center Support Grant. ..
  48. OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA
    Ajay Gopal; Fiscal Year: 2005
    ..We anticipate that these interventions will ultimately enhance the prognosis for patients with relapsed lymphoma by increasing the response and survival rates, while simultaneously minimizing toxicities. ..
  49. Proapoptotic Therapy for B-cell Non Hodgkin's Lymphoma
    Ajay Gopal; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  50. Immune responses to T-cell expansion + PCV immunization
    Aaron Rapoport; Fiscal Year: 2005
    ..abstract_text> ..
  51. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  52. Gene Modified Donor T Cell Infusion into Mixed Chimeras
    George Georges; Fiscal Year: 2003
    ..If successful, this study could translate into improved control of the GVH reaction and improved survival after allogeneic HCT. ..
  53. GENE MODIFIED T-CELLS FOR ENGRAFTMENT AND GVHD CONTROL
    George Georges; Fiscal Year: 2003
    ..We will test if donor CTL specific for host minor histocompatibility antigens can convert mixed to complete donor chimerism. If successful this would make MHC-matched stem cell transplantation less toxic. ..
  54. BODY WEIGHT SUPPORTED AMBULATION TRAINING AFTER SCI
    Blair Calancie; Fiscal Year: 2004
    ..abstract_text> ..
  55. AXONAL GROWTH IN THE CHRONICALLY INJURED SPINAL CORD
    JOHN HOULE; Fiscal Year: 2003
    ..abstract_text> ..
  56. Improving Platelet Recovery After Radiation
    George Georges; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. LATE EFFECTS IN SURVIVORS OF STEM CELL TRANSPLANTATION
    Kevin Baker; Fiscal Year: 2006
    ..Robison is Principal Investigator) for a comparative analysis of patients in that cohort receiving standard chemotherapy versus those who have undergone SCT as part of their therapy. ..
  58. BD Biosciences FACSAria Benchtop Cell Sorter
    Irving Weissman; Fiscal Year: 2006
    ..Each of the projects described herein requires multi-parameter sorting capability to fulfill one or more of its aims. Thus, we feel the request for purchase of this essential equipment is well justified. [unreadable] [unreadable]..
  59. Improving Function and Persistence of Chimeric T Cells
    Barbara Savoldo; Fiscal Year: 2006
    ..The data produced by this project will be crucial to develop appropriate clinical trails with redirected T cells. ..
  60. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2008
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
  61. Transfer of IL-1Ra cDNA to Osteoarthritic Knee
    Christopher Evans; Fiscal Year: 2008
    ..abstract_text> ..
  62. PROSPECTIVE STUDY OF ANKLE INJURY RISK FACTORS
    Bruce Beynnon; Fiscal Year: 2002
    ..abstract_text> ..