mediastinoscopy

Summary

Summary: Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.

Top Publications

  1. ncbi Cervical mediastinoscopy in The Netherlands: past or present? A retrospective analysis of 218 procedures
    P W Plaisier
    Department of General Surgery, Medisch Spectrum Twente, Enschede
    Neth J Med 61:253-6. 2003
  2. ncbi Surgical assessment and intraoperative management of mediastinal lymph nodes in non-small cell lung cancer
    Bryan A Whitson
    University of Minnesota Department of Surgery, Section of Thoracic and Foregut Surgery, Minneapolis, Minnesota 55455, USA
    Ann Thorac Surg 84:1059-65. 2007
  3. doi A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer
    Kazuhiro Yasufuku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:1393-400.e1. 2011
  4. ncbi Transesophageal mediastinoscopy by submucosal endoscopy with mucosal flap safety valve technique
    Kazuki Sumiyama
    Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gastrointest Endosc 65:679-83. 2007
  5. pmc Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study
    Neal Navani
    Center for Respiratory Research, University College London, London
    J Thorac Oncol 6:1505-9. 2011
  6. ncbi Natural orifice transesophageal mediastinoscopy and thoracoscopy
    F F Willingham
    Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114 3117, USA
    Surg Endosc 22:1042-7. 2008
  7. doi Natural orifice transesophageal mediastinoscopy and thoracoscopy: a survival series in swine
    Denise W Gee
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Wang Ambulatory Care Center 460, 15 Parkman Street, Boston, MA 02114 3117, USA
    Surg Endosc 22:2117-22. 2008
  8. doi Diagnosis of mediastinal adenopathy-real-time endobronchial ultrasound guided needle aspiration versus mediastinoscopy
    Armin Ernst
    Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Thorac Oncol 3:577-82. 2008
  9. doi Mediastinoscopy: still the gold standard
    Joseph B Shrager
    Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    Ann Thorac Surg 89:S2084-9. 2010
  10. ncbi Results of preoperative mediastinoscopy for small cell lung cancer
    M Inoue
    Department of Surgery, Osaka Prefectural Habikino Hospital, Habikino City, Japan
    Ann Thorac Surg 70:1620-3. 2000

Detail Information

Publications201 found, 100 shown here

  1. ncbi Cervical mediastinoscopy in The Netherlands: past or present? A retrospective analysis of 218 procedures
    P W Plaisier
    Department of General Surgery, Medisch Spectrum Twente, Enschede
    Neth J Med 61:253-6. 2003
    Cervical mediastinoscopy (CM) has been considered the gold standard for the evaluation of mediastinal lymph nodes in the staging of non-small cell lung cancer (NSCLC) for many years...
  2. ncbi Surgical assessment and intraoperative management of mediastinal lymph nodes in non-small cell lung cancer
    Bryan A Whitson
    University of Minnesota Department of Surgery, Section of Thoracic and Foregut Surgery, Minneapolis, Minnesota 55455, USA
    Ann Thorac Surg 84:1059-65. 2007
    ..Pathologic evaluation of at least 10 mediastinal lymph node from at least three stations should be performed at the time of surgery...
  3. doi A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer
    Kazuhiro Yasufuku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:1393-400.e1. 2011
    The study objective was to compare endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with mediastinoscopy for mediastinal lymph node staging of potentially resectable non-small cell lung cancer.
  4. ncbi Transesophageal mediastinoscopy by submucosal endoscopy with mucosal flap safety valve technique
    Kazuki Sumiyama
    Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gastrointest Endosc 65:679-83. 2007
    ..Indications for NOTES (natural orifice transluminal endoscopic surgery) studied so far are limited to intra-abdominal surgery...
  5. pmc Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study
    Neal Navani
    Center for Respiratory Research, University College London, London
    J Thorac Oncol 6:1505-9. 2011
    ..Invasive sampling of intrathoracic lymph nodes may be performed by mediastinoscopy or endoscopic ultrasound-guided fine needle aspiration...
  6. ncbi Natural orifice transesophageal mediastinoscopy and thoracoscopy
    F F Willingham
    Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114 3117, USA
    Surg Endosc 22:1042-7. 2008
    Thoracoscopy and mediastinoscopy are common procedures with painful incisions and prominent scars...
  7. doi Natural orifice transesophageal mediastinoscopy and thoracoscopy: a survival series in swine
    Denise W Gee
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Wang Ambulatory Care Center 460, 15 Parkman Street, Boston, MA 02114 3117, USA
    Surg Endosc 22:2117-22. 2008
    Transesophageal endoscopic mediastinoscopy (MX) and thoracoscopy (TX) could reduce pain, eliminate intercostal neuralgia, provide better access to the posterior mediastinal compartment and pulmonary hilum, and improve cosmesis...
  8. doi Diagnosis of mediastinal adenopathy-real-time endobronchial ultrasound guided needle aspiration versus mediastinoscopy
    Armin Ernst
    Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Thorac Oncol 3:577-82. 2008
    ..Nevertheless, direct comparisons with mediastinoscopy are not available to determine the role of endobronchial ultrasound in pathologic staging.
  9. doi Mediastinoscopy: still the gold standard
    Joseph B Shrager
    Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    Ann Thorac Surg 89:S2084-9. 2010
    Endobronchial ultrasound (EBUS-TBNA) is emerging as an alternative to mediastinoscopy for mediastinal lymph node evaluation in non-small cell lung cancer. It remains controversial whether EBUS-TBNA is as accurate as mediastinoscopy...
  10. ncbi Results of preoperative mediastinoscopy for small cell lung cancer
    M Inoue
    Department of Surgery, Osaka Prefectural Habikino Hospital, Habikino City, Japan
    Ann Thorac Surg 70:1620-3. 2000
    The significance of mediastinoscopy for small cell lung cancer is unclear owing to the small number of surgical cases.
  11. doi Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial
    Jouke T Annema
    Department of Pulmonology, C3 P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    JAMA 304:2245-52. 2010
    ..Current guidelines acknowledge minimally invasive endosonography followed by surgical staging (if no nodal metastases are found by endosonography) as an alternative to immediate surgical staging...
  12. doi Natural orifice transluminal endoscopic surgery: cardiopulmonary safety of transesophageal mediastinoscopy
    S von Delius
    Medizinische Klinik II, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Endoscopy 42:405-12. 2010
    Physiological reactions during natural orifice transluminal endoscopic surgery (NOTES) mediastinoscopy may lead to cardiorespiratory depression...
  13. ncbi Thoracoscopic esophagectomy combined with mediastinoscopy via the neck
    Yoshifumi Ikeda
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Ann Thorac Surg 73:1329-31. 2002
    ..Therefore, a thoracoscopic esophagectomy combined with this technique allows mediastinal lymph nodes along the left recurrent laryngeal nerve to be easily and safely dissected...
  14. doi Randomized comparative long-term survival study of endoscopic and thoracoscopic esophageal wall repair after NOTES mediastinoscopy in healthy and compromised animals
    A Fritscher-Ravens
    Homerton University Hospital, London, UK
    Endoscopy 42:468-74. 2010
    ..We compared endoscopic with thoracoscopic esophageal wall repair after full-thickness esophageal wall incision (FTEI) and NOTES mediastinoscopy in healthy versus compromised animals.
  15. ncbi Video-assisted mediastinoscopy: experience from 240 consecutive cases
    Nicolas Venissac
    Service de Chirurgie Thoracique, Hopital Pasteur, C H U de Nice, Nice, France
    Ann Thorac Surg 76:208-12. 2003
    We report our experience with video-assisted mediastinoscopy.
  16. ncbi The transcervical extended mediastinal lymphadenectomy versus cervical mediastinoscopy in non-small cell lung cancer staging
    Jarosław Kuzdzał
    Department of Thoracic Surgery, Pulmonary Hospital Zakopane, Poland
    Eur J Cardiothorac Surg 31:88-94. 2007
    To compare the diagnostic yield of the transcervical extended mediastinal lymphadenectomy (TEMLA) and the cervical mediastinoscopy (CM) in detecting metastatic mediastinal lymph nodes in NSCLC patients.
  17. doi Mediastinoscopy in patients with lung cancer and negative endobronchial ultrasound guided needle aspiration
    Sebastian A Defranchi
    Division of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 90:1753-7. 2010
    ..with transbronchial needle aspiration (EBUS-TBNA) has been proposed as a safe, less-invasive alternative to mediastinoscopy to stage mediastinal lymph nodes in patients with lung cancer...
  18. doi The role of extended cervical mediastinoscopy in staging of non-small cell lung cancer of the left lung and a comparison with integrated positron emission tomography and computed tomography: does integrated positron emission tomography and computed tomogr
    Muzaffer Metin
    Yedikule Thoracic Surgery and Chest Disease Education and Research Hospital, Istanbul, Turkey
    J Thorac Oncol 6:1713-9. 2011
    Extended cervical mediastinoscopy (ECM) is a method for sampling aortopulmonary window (APW) mediastinal lymph nodes...
  19. ncbi [Complications of mediastinoscopy]
    Cristian Paleru
    Clinica de Chirurgie Toracică, Institutul de Pneumologie, Marius Nasta, Bucuresti
    Pneumologia 58:39-40, 42. 2009
    b>Mediastinoscopy is a minimum invasive investigation representing a reference in mediastinum exploration and having a major role regarding therapeutic strategies in patients with lung cancer or other mediastinal pathology...
  20. ncbi Mediastinoscopy in superior vena cava obstruction: analysis of 80 consecutive patients
    T C Mineo
    Department of Thoracic Surgery, Tor Vergata University, Rome, Italy
    Ann Thorac Surg 68:223-6. 1999
    Prejudices against mediastinoscopy in superior vena cava obstruction still remain. Hereby we analyze risk/benefit balance in a large series of patients.
  21. ncbi The value of video-assisted mediastinoscopy in pulmonary metastasectomy
    Ashvini Menon
    St James University Hospital, Leeds, United Kingdom
    Eur J Cardiothorac Surg 32:351-4; discussion 354-5. 2007
    To assess the role of video-assisted mediastinoscopy (VAM) in identifying involved mediastinal lymph nodes in patients undergoing pulmonary metastasectomy.
  22. doi A novel technique of mediastinoscopy-assisted esophagectomy with a flexible laparoscope and endoscopic overtube
    Kenji Mimatsu
    Department of Surgery, Social Insurance Yokohama Central Hospital, Kanagawa, Japan
    Surg Laparosc Endosc Percutan Tech 20:e44-6. 2010
    In mediastinoscopy-assisted esophagectomy, mobilizing the thoracic esophagus with visualization through the mediastinoscope is often difficult...
  23. doi Successful management of severe pulmonary artery injury during mediastinoscopy
    Takeshi Nagayasu
    Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Gen Thorac Cardiovasc Surg 59:73-6. 2011
    Although many reports have shown that mediastinoscopy is an extremely safe procedure, the most serious complication that can occur is hemorrhage from the large vessels in the mediastinum...
  24. ncbi Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage II
    Paul De Leyn
    Department of Thoracic Surgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 24:3333-9. 2006
    ....
  25. ncbi Routine mediastinoscopy and esophageal ultrasound fine-needle aspiration in patients with non-small cell lung cancer who are clinically N2 negative: a prospective study
    Robert James Cerfolio
    Division of Cardiothoracic Surgery, University of Alabama at Birmingham, 1900 University Blvd, THT 712, Birmingham, AL 35294, USA
    Chest 130:1791-5. 2006
    ..N2) lymph nodes shown on positron emission tomography (PET) and CT, some physicians routinely perform mediastinoscopy and/or endoscopic ultrasound fine-needle aspiration (EUS-FNA) in patients with non-small cell lung cancer (..
  26. ncbi Video-assisted mediastinoscopy: a useful technique for paratracheal mesothelial cysts
    Daniel Pop
    Thoracic Surgery Department, Pasteur Hospital, Nice, France
    J Thorac Cardiovasc Surg 129:690-1. 2005
  27. ncbi The role of 11C-choline positron emission tomography-computed tomography and videomediastinoscopy in the evaluation of diseases of middle mediastinum
    Qi Liu
    Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan 250021, China
    Chin Med J (Engl) 119:634-9. 2006
    ..We compared histologic findings, videomediastinoscopy, computed tomography (CT), and PET-CT in patients with mediastinal disease...
  28. ncbi Management of major hemorrhage during mediastinoscopy
    Bernard J Park
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 867, New York, NY 10021, USA
    J Thorac Cardiovasc Surg 126:726-31. 2003
    The management of major hemorrhage complicating mediastinoscopy is not well described. We reviewed our experience to determine the frequency, optimal management strategy, and outcome of these injuries.
  29. doi Mediastinal staging procedures in lung cancer: EBUS, TBNA and mediastinoscopy
    Andrew R L Medford
    Department of Respiratory Medicine, Allergy and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester LE3 9QP, Leicestershire, UK
    Curr Opin Pulm Med 15:334-42. 2009
    ..Traditionally, cervical mediastinoscopy has been utilized...
  30. doi Mediastinoscopy might not be necessary in patients with non-small cell lung cancer with mediastinal lymph nodes having a maximum standardized uptake value of less than 5.3
    Benjamin Enoch Lee
    Division of Cardiothoracic Surgery, University of California at Davis, Sacramento, Calif 95817, USA
    J Thorac Cardiovasc Surg 135:615-9. 2008
    ..predictor of individual lymph node metastasis in non-small cell lung cancer and that pathologic staging with mediastinoscopy might not be necessary in patients with a maximum standardized uptake value of less than 5...
  31. ncbi Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer
    Jouke T Annema
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 294:931-6. 2005
    ..b>Mediastinoscopy and the novel, minimally invasive technique of transesophageal ultrasound-guided fine-needle aspiration (EUS-..
  32. doi Endovascular treatment of a brachiocephalic artery pseudoaneurysm secondary to biopsy at mediastinoscopy
    Irfan Ahmed
    Department of Interventional Radiology, Guy s and St Thomas Hospitals, NHS Foundation Trust, London, SE1 7EH, UK
    Cardiovasc Intervent Radiol 32:792-5. 2009
    ..We report the case of a 53-year-old lymphoma patient who had had a biopsy at mediastinoscopy in the past and was found incidentally on routine staging computed tomography to have developed a large ..
  33. ncbi Mediastinal lymph node staging in suspected lung cancer: comparison of positron emission tomography with F-18-fluorodeoxyglucose and mediastinoscopy
    Thomas P Graeter
    Department of Thoracic and Cardiovascular Surgery, Saarland University Medical School, Homburg Saar, Germany
    Ann Thorac Surg 75:231-5; discussion 235-6. 2003
    ..In this retrospective analysis we compared the results of positron emission tomography (PET) using F-18 fluorodeoxyglucose with those of mediastinoscopy in nodal staging for suspected bronchogenic carcinoma.
  34. ncbi [Mediastinoscopy in the diagnosis of mediastinal disease. An analysis of 181 explorations]
    P Rodriguez
    Servicio de Cirugía Torácica, Hospital de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Espana
    Arch Bronconeumol 39:29-34. 2003
    To validate our experience with standard cervical mediastinoscopy (SCM) and extended cervical mediastinoscopy (ECM) to diagnose mediastinal nodes and masses, we studied 181 patients between January 1992 and February 2001...
  35. ncbi Nine-year single center experience with cervical mediastinoscopy: complications and false negative rate
    Anthony Lemaire
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 82:1185-9; discussion 1189-90. 2006
    b>Mediastinoscopy is a valuable tool for evaluating mediastinal pathology and is essential for establishing treatment strategies in most patients with lung cancer...
  36. ncbi Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer
    Bryan F Meyers
    Division of Cardiothoracic Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Thorac Cardiovasc Surg 131:822-9; discussion 822-9. 2006
    ..tomography may identify mediastinal lymph node metastasis with sufficient sensitivity to allow omission of mediastinoscopy. This study utilizes our experience with patients with clinical stage I lung cancer to perform a decision ..
  37. ncbi Endoscopic ultrasound-guided fine-needle aspiration in patients with non-small cell lung cancer and prior negative mediastinoscopy
    Mohamad A Eloubeidi
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama, Birmingham, Alabama 35294 0007, USA
    Ann Thorac Surg 80:1231-9. 2005
    b>Mediastinoscopy and endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) are complementary for staging non-small cell lung cancer (NSCLC) patients...
  38. ncbi Should mediastinoscopy actually be incorporated into the FDG PET strategy for patients with non-small cell lung carcinoma?
    Katsumi Hayashi
    Department of Radiology, National Defense Medical College, Tokorozawa, Japan
    Ann Nucl Med 19:393-8. 2005
    Incorporating mediastinoscopy (MS) into the PET-based strategy for non-small cell lung carcinoma (NSCLC) patients might be cost-effective because MS can allow unnecessary thoracotomies to be avoided...
  39. ncbi Positron emission tomography with selected mediastinoscopy compared to routine mediastinoscopy offers cost and clinical outcome benefits for pre-operative staging of non-small cell lung cancer
    Kelvin K Yap
    Centre for PET, University of Melbourne, Austin Hospital Heidelberg, Victoria, 3084, Australia
    Eur J Nucl Med Mol Imaging 32:1033-40. 2005
    ..through a decision tree model and the incorporation of real costs of each component, that routine FDG-PET imaging as a prelude to curative surgery will reduce requirements for routine mediastinoscopy and overall hospital costs.
  40. ncbi Endoscopic ultrasound guided biopsy versus mediastinoscopy for analysis of paratracheal and subcarinal lymph nodes in lung cancer staging
    Soeren S Larsen
    Department of Cardio Thoracic Surgery, Gentofte University Hospital, Copenhagen, Denmark
    Lung Cancer 48:85-92. 2005
    ..b>Mediastinoscopy (MS) and endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) are considered complementary, ..
  41. ncbi [Mediastinoscopy]
    R Sarrazin
    Service de Chirurgie Generale, CHRU, Grenoble
    Rev Mal Respir 9:99-110. 1992
    b>Mediastinoscopy was initiated by E. Carlens in 1959 and enabled the exploration of the mediastinal tissues, above all the lymphatics with both a diagnostic and a prognostic aim...
  42. ncbi Surgical exploration of the mediastinum by mediastinoscopy, parasternal mediastinotomy and remediastinoscopy: indications, technique and complications
    R Rami Porta
    Section of Thoracic Surgery, Hospital Mutua de Terrassa, Barcelona, Spain
    Ann Ital Chir 70:867-72. 1999
    ..Surgical exploration of the mediastinum by mediastinoscopy allows to obtain very accurate information from inspection, palpation and biopsies of lymph nodes or tumors ..
  43. ncbi Diagnostic yield of mediastinal exploration
    Waseem Hajjar
    Thoracic Surgery Division, Department of Surgery, King Khalid University Hospital, Riyadh, Saudi Arabia
    Med Princ Pract 11:210-3. 2002
    ..To report our experiences of surgical diagnostic procedures in patients with unidentified mediastinal pathology...
  44. ncbi Mediastinal transthoracic needle and core lymph node biopsy: should it replace mediastinoscopy?
    Joseph B Zwischenberger
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Chest 121:1165-70. 2002
    Primary assessment of mediastinal lymph nodes (N2 or N3) for staging lung cancer by transthoracic needle with or without core biopsy. Mediastinoscopy only performed after FNA failed to yield a diagnosis.
  45. ncbi The complete ''medical'' mediastinoscopy (EUS-FNA + EBUS-TBNA)
    P Vilmann
    Department of Surgical Gastroenterology, Gentofte University Hospital, Copenhagen, Denmark
    Minerva Med 98:331-8. 2007
    ..diagnoses include computed tomography (CT)-guided percutaneous biopsy, transbronchial fine-needle aspiration, mediastinoscopy/mediastinotomy or thoracoscopy, but these investigations have limitations in terms of tissue yield, safety ..
  46. ncbi A comparative analysis of positron emission tomography and mediastinoscopy in staging non-small cell lung cancer
    Gonzalo V Gonzalez-Stawinski
    Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 126:1900-5. 2003
    ..This study compares the efficacy of PET to mediastinoscopy in mediastinal staging of patients with non-small cell lung cancer.
  47. ncbi Can FDG-PET reduce the need for mediastinoscopy in potentially resectable nonsmall cell lung cancer?
    Kemp H Kernstine
    Department of Biostatistics, College of Public Health, University of Iowa, and Iowa City Veterans Administration Medical Center, USA
    Ann Thorac Surg 73:394-401; discussion 401-2. 2002
    ..We question whether once PET is performed, is mediastinoscopy necessary?
  48. ncbi Positron emission tomography with 2-[18f]fluoro-2-deoxy-D-glucose: can it be used to accurately stage the mediastinum in non-small cell lung cancer as an alternative to mediastinoscopy?
    Kemp H Kernstine
    J Thorac Cardiovasc Surg 126:1700-3. 2003
  49. ncbi The significance of tumour markers as an indication for mediastinoscopy in non-small cell lung cancer
    Soichiro Ando
    Division of Thoracic Diseases, Chiba Cancer Center and Department of Chest Medicine, Chiba University School of Medicine, Chiba, Japan
    Respirology 8:163-7. 2003
    The purpose of this study was to verify the significance of tumour markers as indicators for mediastinoscopy in non-small cell lung cancer.
  50. ncbi Result of induction chemotherapy followed by surgery in patients with stage IIIA N2 NSCLC: importance of pre-treatment mediastinoscopy
    P De Leyn
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    Eur J Cardiothorac Surg 15:608-14. 1999
    ..The aim of this study was to look at the correlation between downstaging, survival and pre-treatment staging...
  51. ncbi Simultaneous double video mediastinoscopy and video mediastinotomy--a step forward
    Shishir Karthik
    Department of Thoracic Surgery, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Eur J Cardiothorac Surg 27:920-2. 2005
    ..a novel method of using the video-mediastinoscope for concurrent cervical mediastinotomy and anterior mediastinoscopy. We have performed five concurrent procedures using this system in the last 14 months...
  52. ncbi Video-mediastinoscopy in management of patients with lung cancer: a preliminary study
    N Venissac
    Service de Chirurgie Thoracique, Hopital Pasteur, CHU de Nice, France
    Surg Laparosc Endosc Percutan Tech 10:71-5. 2000
    Cervical mediastinoscopy is widely employed for biopsy of mediastinal lymph nodes and staging of lung cancer. The application of video-assisted technology to mediastinoscopy in a series of patients with lung cancer has not been reported...
  53. ncbi European trends in preoperative and intraoperative nodal staging: ESTS guidelines
    P De Leyn
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
    J Thorac Oncol 2:357-61. 2007
    ..For primary staging, mediastinoscopy remains the gold standard for the superior mediastinal LNs...
  54. ncbi The importance of accurate lymph node staging in early and locally advanced non-small cell lung cancer: an update on available techniques
    Edward S Kim
    MD Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Thorac Oncol 2:S59-67. 2007
    ..minimally invasive techniques that may enhance the accuracy of mediastinal staging, traditionally devoted to mediastinoscopy. As their availability widens, they are likely to become an important part of staging and treatment paradigms...
  55. ncbi Selection of patients for surgery after induction chemotherapy for N2 non-small-cell lung cancer
    Peter Goldstraw
    J Clin Oncol 24:3317-8. 2006
  56. ncbi State of the art lecture: mediastinal EUS
    P Vilmann
    Department of Surgical Gastroenterology, Gentofte University Hospital, Copenhagen, Denmark
    Endoscopy 38:S84-7. 2006
  57. ncbi [Clinical value of videomediastinoscopy in diagnosis of mediastinal disease]
    Zhong min Peng
    Department of Thoracic Surgery, Shandong Provincal Hospital, Jinan 250021, China
    Zhonghua Yi Xue Za Zhi 86:1414-6. 2006
    ..To evaluate the role of videomediastinoscopy in the diagnosis of disease of the mediastinum...
  58. doi [Introduction to the topic: current diagnosis and surgery of the mediastinum]
    J Schirren
    Abteilung für Thoraxchirurge, Kerckhoff Klinik, Benekestrasse 2 8, 61231, Bad Nauheim, Germany
    Chirurg 79:6-8. 2008
  59. doi [Role of mediastinoscopy and repeat mediastinoscopy today]
    M Hinterthaner
    Klinik for Allgemeinchirurgie, Klinikum Kassel, Kassel, Germany
    Chirurg 79:38, 40-4. 2008
    ..Cervical mediastinoscopy is generally accepted as a safe and highly accurate procedure in the staging of lung cancer...
  60. doi Invasive mediastinal staging for non-small-cell lung cancer
    Linda W Martin
    Gastrointest Endosc 67:199-201. 2008
  61. ncbi IIIB-T4 non-small cell lung cancer: indications and results of surgical treatment
    M Lucchi
    Division of Thoracic Surgery, Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    J Cardiovasc Surg (Torino) 48:369-74. 2007
    ..We have reviewed our experience with T4 NSCLC patients who underwent surgery with the aim of debating the indications and results of surgical treatment in this highly selected group of patients...
  62. ncbi Mediastinal staging 2005: pictures, scopes, and scalpels
    Harvey I Pass
    Thoracic Oncology Section, Multidisciplinary Lung Team, Karmanos Cancer Institute, Detroit, MI, USA
    Semin Oncol 32:269-78. 2005
    ....
  63. ncbi Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR
    Xiao Tao Wang
    Department of Thoracic Surgery, Albert Ludwigs University Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 28:26-32. 2005
    ..This prospective study was performed to evaluate a simple and observer-independent polymerase chain reaction (PCR)-based method for the detection of disseminated tumor cells in regional lymph nodes...
  64. doi Survival of patients with unsuspected N2 (stage IIIA) nonsmall-cell lung cancer
    Robert J Cerfolio
    Department of Surgery, Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann Thorac Surg 86:362-6; discussion 366-7. 2008
    ..The objective of this study was to determine the survival of patients who have completely resected, nonsmall-cell, stage IIIA, lung cancer from unsuspected (nonimaged) N2 disease who received adjuvant chemotherapy...
  65. ncbi Easier node dissection after chemoradiotherapy for lung cancer with collagen insertion at mediastinoscopy
    Kenichi Okubo
    General Thoracic Surgery, National Hospital Organization Nagara Medical Center, Gifu, Japan
    Jpn J Thorac Cardiovasc Surg 54:268-72. 2006
    ..Dense peritracheal fibrosis and sclerosis after chemoradiotherapy cause difficult mediastinal node dissection. We evaluated a novel technique to make the mediastinal node dissection easier after induction therapy...
  66. ncbi Pattern and predictors of occult mediastinal lymph node involvement in non-small cell lung cancer patients with negative mediastinal uptake on positron emission tomography
    Nael Al-Sarraf
    Department of Cardiothoracic Surgery, St James s Hospital, Dublin 8, Ireland
    Eur J Cardiothorac Surg 33:104-9. 2008
    ....
  67. ncbi Video-assisted mediastinoscopic lymphadenectomy (VAMLA)
    Biruta Witte
    Lungenzentrum, Sektion Thoraxchirurgie, Katholisches Klinikum Koblenz, Koblenz, Germany
    J Thorac Oncol 2:367-9. 2007
    ..Concurrent with technical progress in mediastinoscopy, neoadjuvant treatment of stage III lung cancer was introduced, and accuracy of pretreatment mediastinal ..
  68. ncbi Is lobe-specific lymph node dissection appropriate in lung cancer patients undergoing routine mediastinoscopy?
    A Turna
    Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey
    Thorac Cardiovasc Surg 55:112-9. 2007
    ..We aimed to analyze the lobe-specific extent of lymph node positivity in patients who underwent preoperative mediastinoscopy as a routine strategy.
  69. ncbi Survival following complete resection of multifocal T4 node-negative NSCLC: a retrospective study
    A Terzi
    Thoracic Surgery Unit, Verona City Hospital, Verona, Italy
    Thorac Cardiovasc Surg 55:44-7. 2007
    ..This study was designed to assess the impact of multifocal NSCLC in the same lobe on survival in completely resected node-negative patients to determine whether the T4 (stage III B) designation is valid...
  70. ncbi [Combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the staging of lung cancer]
    Noriyoshi Sawabata
    Department of Cardio Thoracic Surgery, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Kyobu Geka 60:699-705. 2007
    The application of combined video-mediastinoscopy and video-thoracoscopy in the staging of lung cancer has remained infrequent, despite preliminary demonstration of its technical feasibility...
  71. ncbi [Analysis of the treatment (neoadjuvant chemotherapy and surgery) in IIb and IIIa stages of non-small cell lung cancer]
    Beata Ptaszek
    III Klinika Chorób Pluc, Instytutu Gruźlicy i Chorób Płuc, Warszawie
    Pneumonol Alergol Pol 74:171-8. 2006
    1) comparison of NSCLC stages according to bronchoscopic and radiological findings with pathological outcome (mediastinoscopy), 2) efficacy of the neoadjuvant ChT by means of nodal involvement and primary tumour (downstaging), 3) ..
  72. ncbi Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Frank C Detterbeck
    Division of Thoracic Surgery, Department of Surgery, Yale University, 330 Cedar St, FMB 128, New Haven, CT 06520 8062, USA
    Chest 132:202S-220S. 2007
    ..Although imaging studies can provide some guidance, in many situations invasive staging is necessary. Many different complementary techniques are available...
  73. ncbi Women with pathologic stage I, II, and III non-small cell lung cancer have better survival than men
    Robert James Cerfolio
    Division of Cardiothoracic Surgery, University of Alabama at Birmingham, 1900 University Blvd, THT 712, Birmingham, AL 35294, USA
    Chest 130:1796-802. 2006
    ..National registry-based studies have shown gender disparity in clinicopathologic characteristics and in survival. This study evaluates the risk factors and trends of lung cancer between genders...
  74. ncbi Restaging of mediastinal nodes with transbronchial needle aspiration after induction chemoradiation for locally advanced non-small cell lung cancer
    Peter W A Kunst
    Department of Pulmonology, Haga Hospital, Den Haag, The Netherlands
    J Thorac Oncol 2:912-5. 2007
    ..However, nodal restaging can be technically difficult. We investigated the role of transbronchial needle aspiration (TBNA) in mediastinal restaging of patients who had completed induction cytotoxic therapy...
  75. ncbi Technical innovations of carinal resection for nonsmall-cell lung cancer
    Paolo Macchiarini
    Department of General Thoracic Surgery, University of Barcelona, Barcelona, Spain
    Ann Thorac Surg 82:1989-97; discussion 1997. 2006
    ..We present our perioperative management of operable nonsmall-cell lung cancer invading the tracheobronchial bifurcation and the results obtained...
  76. ncbi Transcervical extended mediastinal lymphadenectomy: results of staging in two hundred fifty-six patients with non-small cell lung cancer
    Marcin Zielinski
    Department of Thoracic Surgery, Pulmonary Hospital, Zakopane, Poland
    J Thorac Oncol 2:370-2. 2007
    ..Generally, TEMLA is an open procedure performed partly with mediastinoscopy-assisted and videothoracoscopy-assisted techniques...
  77. ncbi Proposals for changes in the Mountain and Dresler mediastinal and pulmonary lymph node map
    M Zielinski
    Department of Thoracic Surgery, Pulmonary Hospital, Zakopane, Poland
    J Thorac Oncol 2:3-6. 2007
    ..In our opinion, some modifications of this map are necessary. Based on our experience with extended mediastinoscopy and the new procedure, transcervical extended mediastinal lympadenectomy, the main changes we propose are: 1) ..
  78. ncbi ESTS guidelines for preoperative lymph node staging for non-small cell lung cancer
    Paul De Leyn
    Eur J Cardiothorac Surg 32:1-8. 2007
    ..This resulted in guidelines for primary staging and restaging. For primary staging, mediastinoscopy remains the gold standard for the superior mediastinal lymph nodes...
  79. ncbi Sensitivity of remediastinoscopy: influence of adhesions, multilevel N2 involvement, or surgical technique?
    Paul Van Schil
    J Clin Oncol 24:5338; author reply 5339-40. 2006
  80. ncbi [Transbronchial needle aspiration as a diagnostic method in lung cancer and non-malignant mediastinal adenopathy]
    Artur Szlubowski
    Oddział Pulmonologii i Pracownia Bronchoskopii Samodzielnego Publicznego Specjalistycznego Szpitala Chorób Płuc w Zakopanem Ordynator Oddziału
    Pneumonol Alergol Pol 75:5-12. 2007
    ..The aim of the study was to assess the diagnostic yield of transbronchial needle aspiration (TBNA) in mediastinal or hilar adenopathy in: lung cancer, staging of NSCLC, sarcoidosis and other non-malignant diseases...
  81. ncbi [Clinical value of cervical mediastinoscopy in non-small cell lung cancer of stage I]
    Shi yi Zhang
    Department of Thoracic Surgery, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 24:349-52. 2005
    Whether to apply routine mediastinoscopy to non-small cell lung cancer (NSCLC) of stage I remains controversial...
  82. ncbi [Adhesion or organization during surgery due to mediastinoscopy before induction therapy for non-small cell lung cancer]
    N Sawabata
    Division of Surgery, National Toneyama Hospital, Toyonaka, Japan
    Kyobu Geka 56:441-4. 2003
    We conducted a retrospective study to investigate amounts of adhesion or organization during surgery due to mediastinoscopy before induction therapy for non-small cell lung cancer (NSCLC)...
  83. ncbi Lung cancer staging
    Alan D L Sihoe
    Department of Surgery, Prince of Wales Hospital, Hong Kong, China
    J Surg Res 117:92-106. 2004
    ..This review presents an appraisal of current lung cancer staging modalities, and presents an overview of recent developments in molecular staging...
  84. ncbi [The biopsying of at least 5 mediastinal lymph node stations for presurgical staging in patients with a non-small-cell lung carcinoma]
    M E van Albada
    Academisch Ziekenhuis Groningen, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 148:281-6. 2004
    To determine the additional value of mediastinoscopy/tomy in the pre-surgical staging of non-small-cell lung carcinoma.
  85. ncbi The restaging issue
    P Van Schil
    Department of Thoracic and Vascular Surgery, University Hospital of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Antwerp, Belgium
    Lung Cancer 42:S39-45. 2003
    ..The ultimate overall pathologic response can only be determined by thoracotomy with excision of the primary tumour, hilar and mediastinal lymph nodes...
  86. ncbi From clinical and pathologic to molecular staging of lung cancer
    Pierre P Massion
    Am J Respir Crit Care Med 167:1587-8. 2003
  87. ncbi Non-small cell lung cancer staging techniques and endoscopic ultrasound: tissue is still the issue
    Julia Kim LeBlanc
    Department of Medicine, Indiana University, Indianapolis 46202, USA
    Chest 123:1718-25. 2003
    ..Histologic confirmation via EUS-guided fine-needle aspiration, however, may still be necessary to accurately stage the mediastinum...
  88. ncbi [Endoscopic thoracic surgery: indications, feasibility, and limitations]
    H Dienemann
    Chirurgische Abteilung, Thoraxklinik Heidelberg
    Chirurg 74:324-32. 2003
    b>Mediastinoscopy and mediastinotomy are used primarily in the staging of lung cancer; they are also of value in biopsying mediastinal masses and lymph nodes to establish diagnoses such as sarcoidosis,lymphoma, and mediastinal tumors...
  89. ncbi Postinduction video-mediastinoscopy is as accurate and safe as video-mediastinoscopy in patients without pretreatment for potentially operable non-small cell lung cancer
    Didier Lardinois
    Division of Thoracic Surgery and Institute of Medical Oncology, Inselspital Bern, Bern, Switzerland
    Ann Thorac Surg 75:1102-6. 2003
    Prospective assessment of accuracy and safety of video-mediastinoscopy (VMS) in patients without pretreatment and those after induction therapy for potentially operable non-small cell lung cancer.
  90. ncbi Detection of telomerase expression in mediastinal lymph nodes of patients with lung cancer
    Michael B Wallace
    Division of Gastroenterology, Digestive Diseases Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 167:1670-5. 2003
    ..Approximately one-third of pathologically negative mediastinal lymph nodes in NSCLC patients express hTERT mRNA. The clinical significance of this observation is yet to be determined...
  91. ncbi Lung cancer. Invasive staging: the guidelines
    Frank C Detterbeck
    Multidisciplinary Thoracic Oncology Program, Division of Cardiothoracic Surgery, University of North Carolina, CB 7065, 108 Burnett Womack Building, Chapel Hill, NC 27599 7065, USA
    Chest 123:167S-175S. 2003
    A variety of invasive staging tests are available, including mediastinoscopy, thoracoscopy (video-assisted thoracoscopic surgery), transbronchial needle aspiration (TBNA), transthoracic needle aspiration (TTNA), and endoscopic ultrasound ..
  92. ncbi Invasive staging of non-small cell lung cancer: a review of the current evidence
    Eric M Toloza
    Department of Surgery, Duke Thoracic Oncology, Duke University Medical Center Box 3048, Durham, NC 27710, USA
    Chest 123:157S-166S. 2003
    ..performance characteristics of transbronchial needle aspiration (TBNA), transthoracic needle aspiration (TTNA), endoscopic ultrasound-guided needle aspiration (EUS-NA), and mediastinoscopy in staging non-small cell lung cancer (NSCLC).
  93. ncbi Invasive staging of non-small cell lung cancer--a prospective study
    S Eggeling
    Department of Surgery, Oskar Ziethen Hospital, Fanninger Strasse 32, D 10365 Berlin, Germany
    Eur J Cardiothorac Surg 22:679-84. 2002
    ..To assess the lymph node status of the upper mediastinum, the diagnostic value of mediastinoscopy is accepted to be superior to radiological methods...
  94. ncbi Routine mediastinoscopy and lymph node staging: 'much ado about nothing'?
    Antonie Dujon
    Eur J Cardiothorac Surg 22:485; author reply 486. 2002
  95. ncbi The value of mediastinoscopy in preoperative evaluation of mediastinal involvement in non-small-cell lung cancer patients with clinical NO disease
    A Gurses
    Yedikule Hospital for Chest Disease and Thoracic Surgery, Istanbul, Turkey
    Thorac Cardiovasc Surg 50:174-7. 2002
    The efficacy of mediastinal lymph node examination using cervical mediastinoscopy in operable non-small cell lung cancer patients without radiological nodal involvement on computerized tomography (CT) has been elusive.
  96. ncbi Cost-minimization analysis of alternative diagnostic approaches in a modeled patient with non-small cell lung cancer and subcarinal lymphadenopathy
    Gavin C Harewood
    Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:155-64. 2002
    ..To evaluate the costs of alternative diagnostic evaluations of enlarged subcarinal lymph nodes (SLNs) in modeled patients with non-small cell lung cancer (NSCLC)...
  97. ncbi Accuracy and cost-effectiveness of [18F]-2-fluoro-deoxy-D-glucose-positron emission tomography scan in potentially resectable non-small cell lung cancer
    Rosemary F Kelly
    University of Minnesota, Minneapolis, USA
    Chest 125:1413-23. 2004
    ....
  98. ncbi Association between lower lobe location and upstaging for early-stage non-small cell lung cancer
    Ana T Rocha
    Division of Pulmonary Medicine, Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Chest 125:1424-30. 2004
    ..To identify factors associated with a misclassification of the true disease stage by comparing the differences between the clinical and pathologic stage of patients with early-stage non-small cell lung cancer (NSCLC)...
  99. ncbi [The biopsying of at least 5 mediastinal lymph node stations for presurgical staging in patients with a non-small-cell lung carcinoma]
    A F Verhagen
    Ned Tijdschr Geneeskd 148:908; author reply 908-9. 2004
  100. ncbi Cotton-type collagen insertion at mediastinoscopy for easier node dissection after induction chemoradiotherapy for lung cancer
    Kenichi Okubo
    Department of General Thoracic Surgery, Gifu National Hospital, Japan
    J Thorac Cardiovasc Surg 127:1532-3. 2004
  101. ncbi Imprint cytology for detecting metastasis of lung cancer in mediastinal lymph nodes
    Kenichi Okubo
    General Thoracic SurgeryGifu National Hospital, Gifu, Japan
    Ann Thorac Surg 78:1190-3. 2004
    ..Lymph node metastasis of lung cancer has been evaluated with histologic examination. We studied the usefulness of cytologic diagnosis for detecting metastasis of lung cancer in mediastinal nodes...

Research Grants39

  1. A Population-Based Analysis of Mediastinal Staging for Non-Small Cell Lung Cancer
    Farhood Farjah; Fiscal Year: 2007
    ..whether geographic area and/or patient characteristics predict the use of computed tomography, PET, and mediastinoscopy in combination...
  2. SYNERGISTIC CT BRONCHOSCOPY FOR LUNG CANCER ASSESSMENT
    William Higgins; Fiscal Year: 2001
    ..Finally, our proposed visual and quantitative methodology could have direct applicability to other endoscopic procedures such as mediastinoscopy, colonoscopy (colorectal cancer), and cystoscopy (bladder cancer).
  3. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..computed tomography, positron emission tomography), or are invasive requiring general anesthesia (mediastinoscopy, thoracoscopy)...
  4. FLT PET to Plan the Best Therapy for Lung Cancer
    Hubert Vesselle; Fiscal Year: 2007
    ..At the conclusion of this study, the insight gained in the response of stage III NSCLCs will allow clinicians to plan the best therapy for these patients. ..
  5. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2007
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  6. RRM1/PTEN Axis in Non-Small Cell Lung Cancer
    Gerold Bepler; Fiscal Year: 2007
    ..The purpose of this application is to corroborate this hypothesis in a prospective phase II clinical trial with gemcitabine-based chemotherapy and radiation in patients with locally advanced inoperable stage III NSCLC. ..
  7. Exisulind for Chemoprevention of Lung Cancer
    Gerold Bepler; Fiscal Year: 2007
    ..The data generated by these investigations will be important for future decisions on large-scale chemoprevention trials using disease incidence and mortality as endpoints. ..
  8. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2009
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  9. THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET
    Hubert Vesselle; Fiscal Year: 2004
    ..By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy. ..
  10. Pharmacogenomics of Neoadjuvant Gemcitabine-Pemetrexed *
    Gerold Bepler; Fiscal Year: 2006
    ....
  11. RRM1 in the Management of Lung Cancer
    Gerold Bepler; Fiscal Year: 2009
    ....
  12. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..The primary outcome will be a reduction in pain at 1 month. Secondary outcomes will include the durability of pain control, quality of life, narcotic use and narcotic side effects. ..