cerebrospinal fluid shunts

Summary

Summary: Tubes inserted to create communication between a cerebral ventricle and the internal jugular vein. Their emplacement permits draining of cerebrospinal fluid for relief of hydrocephalus or other condition leading to fluid accumulation in the ventricles.

Top Publications

  1. ncbi Evaluation of the lumbar and ventricular infusion test in the diagnostic strategy of pediatric hydrocephalus and the therapeutic implications
    Tina Noergaard Munch
    University Clinic of Neurosurgery, Department 2092, The Neuroscience Centre, Rigshospitalet, 2100, Copenhagen, Denmark
    Childs Nerv Syst 23:67-71. 2007
  2. ncbi The scientific history of hydrocephalus and its treatment
    A Aschoff
    University of Heidelberg, Department of Neurosurgery, Germany
    Neurosurg Rev 22:67-93; discussion 94-5. 1999
  3. ncbi Factors related to hydrocephalus after aneurysmal subarachnoid hemorrhage
    Zeena Dorai
    Department of Neurosurgery, University of Texas at Southwestern Medical Center, Dallas 75390 8855, USA
    Neurosurgery 52:763-9; discussion 769-71. 2003
  4. ncbi Shunt revision for asymptomatic failure: surgical and clinical results
    Matthieu Vinchon
    Department of Pediatric Neurosurgery, Centre Hospitalier Regional et Universitaire de Lille, Lille, France
    Neurosurgery 52:347-53; discussion 353-6. 2003
  5. doi Quality of life in children with hydrocephalus: results from the Hospital for Sick Children, Toronto
    Abhaya V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 107:358-64. 2007
  6. ncbi Long-term outcomes in patients with treated childhood hydrocephalus
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco 94102, USA
    J Neurosurg 106:334-9. 2007
  7. doi Headaches in patients with shunts
    Harold L Rekate
    Barrow Neurologic Institute, University of Arizona, College of Medicine, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:27-30. 2009
  8. doi Self-reported functional outcome after surgical intervention in patients with idiopathic normal pressure hydrocephalus
    T A Cage
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, Califonia 94143, USA
    J Clin Neurosci 18:649-54. 2011
  9. ncbi Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters
    Rogier P Schade
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosurg 102:229-34. 2005
  10. ncbi Failure of cerebrospinal fluid shunts: part I: Obstruction and mechanical failure
    Samuel R Browd
    Department of Neurosurgery, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Pediatr Neurol 34:83-92. 2006

Research Grants

  1. A novel in vitro model of thyroid ophthalmopathy
    Steven Feldon; Fiscal Year: 2005
  2. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
  3. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
  4. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2006
  5. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2007
  6. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
  7. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
  8. Quantitative MR measure of MTX neurotoxicity in children
    WILBURN REDDICK; Fiscal Year: 2006
  9. World Workshop in Oral Medicine IV
    Peter Lockhart; Fiscal Year: 2005
  10. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004

Detail Information

Publications200 found, 100 shown here

  1. ncbi Evaluation of the lumbar and ventricular infusion test in the diagnostic strategy of pediatric hydrocephalus and the therapeutic implications
    Tina Noergaard Munch
    University Clinic of Neurosurgery, Department 2092, The Neuroscience Centre, Rigshospitalet, 2100, Copenhagen, Denmark
    Childs Nerv Syst 23:67-71. 2007
    ..To evaluate the infusion test as a diagnostic tool behind the choice of intervention in pediatric hydrocephalus...
  2. ncbi The scientific history of hydrocephalus and its treatment
    A Aschoff
    University of Heidelberg, Department of Neurosurgery, Germany
    Neurosurg Rev 22:67-93; discussion 94-5. 1999
    ..Both new methods, the second generation of valves as well as ventriculostomy, show massive deficits in evaluation. There is only one randomized study and no long-term evaluation...
  3. ncbi Factors related to hydrocephalus after aneurysmal subarachnoid hemorrhage
    Zeena Dorai
    Department of Neurosurgery, University of Texas at Southwestern Medical Center, Dallas 75390 8855, USA
    Neurosurgery 52:763-9; discussion 769-71. 2003
    ..The data can be used to predict which patients in this group have a high probability of requiring permanent cerebrospinal fluid diversion...
  4. ncbi Shunt revision for asymptomatic failure: surgical and clinical results
    Matthieu Vinchon
    Department of Pediatric Neurosurgery, Centre Hospitalier Regional et Universitaire de Lille, Lille, France
    Neurosurgery 52:347-53; discussion 353-6. 2003
    ..The goal of this study was to assess the effects of systematic follow-up monitoring and shunt revision for ASF; we reviewed our database to compare the results of shunt revision for ASF versus SSF...
  5. doi Quality of life in children with hydrocephalus: results from the Hospital for Sick Children, Toronto
    Abhaya V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 107:358-64. 2007
    ..The authors' aim was to quantify the QOL for children with hydrocephalus and identify predictors of long-term outcome, using a reliable and validated outcome measure: the Hydrocephalus Outcome Questionnaire (HOQ)...
  6. ncbi Long-term outcomes in patients with treated childhood hydrocephalus
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco 94102, USA
    J Neurosurg 106:334-9. 2007
    ..The goal in this study was to determine the long-term effects of childhood hydrocephalus...
  7. doi Headaches in patients with shunts
    Harold L Rekate
    Barrow Neurologic Institute, University of Arizona, College of Medicine, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:27-30. 2009
    ..Strategies that lead to normalization of cerebrospinal fluid dynamics and life without shunt dependency are justified if they can be shown to improve later quality of life...
  8. doi Self-reported functional outcome after surgical intervention in patients with idiopathic normal pressure hydrocephalus
    T A Cage
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, Califonia 94143, USA
    J Clin Neurosci 18:649-54. 2011
    ..2% versus 55.6%). Treating idiopathic NPH with cerebrospinal fluid diversion facilitates a return to independence through improved functional and social outcomes...
  9. ncbi Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters
    Rogier P Schade
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosurg 102:229-34. 2005
    ..In the present study the authors compared the incidence and risk factors for external drainage-related bacterial meningitis (ED-BM) by using ventricular and lumbar catheters...
  10. ncbi Failure of cerebrospinal fluid shunts: part I: Obstruction and mechanical failure
    Samuel R Browd
    Department of Neurosurgery, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Pediatr Neurol 34:83-92. 2006
    ..An understanding of the presentation and etiology of shunt dysfunction is critical for neurologists and pediatricians who often are the first to evaluate and triage these children...
  11. doi Risk factors for infections related to external ventricular drainage
    D Hoefnagel
    Erasmus Medical Centre, Department of Neurosurgery, Rotterdam, The Netherlands
    Acta Neurochir (Wien) 150:209-14; discussion 214. 2008
    ..The major complication of this procedure is an EVD-related infection, i.e., meningitis or ventriculitis. The purpose of the present retrospective single centre study is to assess the possible causes of these infections...
  12. doi Treatment of hydrocephalus in adults
    Mark G Hamilton
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Semin Pediatr Neurol 16:34-41. 2009
    ....
  13. ncbi Failure of cerebrospinal fluid shunts: part II: overdrainage, loculation, and abdominal complications
    Samuel R Browd
    Department of Neurosurgery, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Pediatr Neurol 34:171-6. 2006
    Complications from cerebrospinal fluid shunts are common and can present with a variety of signs and symptoms...
  14. pmc Zero tolerance to shunt infections: can it be achieved?
    M S Choksey
    Department of Neurosurgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
    J Neurol Neurosurg Psychiatry 75:87-91. 2004
    ..To evaluate the rigid application of a technique of shunt placement aimed at the eradication of postoperative shunt infection in neurosurgical practice...
  15. ncbi Intraventricular or lumbar infusion test in adult communicating hydrocephalus? Practical consequences and clinical outcome of shunt operation
    R Bech-Azeddine
    University Clinic of Neurosurgery, The Neuroscience Center, Rigshospitalet, H S, Copenhagen, Denmark
    Acta Neurochir (Wien) 147:1027-35; discussion 1035-6. 2005
    ..To investigate the therapeutic consequences of restricting the CSF dynamic evaluation to a lumbar infusion test (LIT), as opposed to our formerly applied intraventricular assessment (VIT), in patients with communicating hydrocephalus (CH)...
  16. ncbi Late shunt infection: incidence, pathogenesis, and therapeutic implications
    M Vinchon
    Department of Pediatric Neurosurgery, CHRU de Lille, France
    Neuropediatrics 33:169-73. 2002
    ..SI represents a life-long threat after shunting, and may be unrelated to shunt surgery...
  17. ncbi Gravitational valves: relevant differences with different technical solutions to counteract hydrostatic pressure
    M Kiefer
    Saarland University, Medical School, Department of Neurosurgery, Homburg Saar, Germany
    Acta Neurochir Suppl 96:343-7. 2006
    ..The frequency and severity of complications was pronounced in the DSV group. We recommend the Aesculap-Miethke-GAV valve with a low opening pressure in a posture-independent valve for patients with NPH...
  18. pmc Acquired Chiari 1 malformation and syringomyelia following lumboperitoneal shunting for pseudotumour cerebri
    R Padmanabhan
    J Neurol Neurosurg Psychiatry 76:298. 2005
  19. doi Evaluation of Strata NSC and Codman Hakim adjustable cerebrospinal fluid shunts and their corresponding antisiphon devices
    Kai Arnell
    Department of Paediatric Surgery, University Hospital, Uppsala, Sweden
    J Neurosurg Pediatr 3:166-72. 2009
    ..The authors investigated and compared the in vitro characteristics of 2 CSF shunts, the Strata NSC and the Codman Hakim, and their corresponding antisiphon devices (ASDs)...
  20. ncbi Diagnosing idiopathic normal-pressure hydrocephalus
    Norman Relkin
    Department of Neurology and Neuroscience, The New York Presbyterian Weill Cornell Medical College, New York, New York, USA
    Neurosurgery 57:S4-16; discussion ii-v. 2005
    ..This report contains evidence-based guidelines for clinical diagnosis of INPH that are intended to facilitate future epidemiological studies of INPH, promote earlier and more accurate diagnosis, and ultimately improve treatment outcome...
  21. ncbi Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219 0449, USA
    J Neurosurg 102:987-97. 2005
    ....
  22. doi The importance of the cortical subarachnoid space in understanding hydrocephalus
    Harold L Rekate
    Pediatric Neurosciences, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neurosurg Pediatr 2:1-11. 2008
    ..The secondary purpose of this work was to define testable hypotheses to explain enigmatic disorders of CSF dynamics and to suggest how these concepts could be tested...
  23. ncbi Use of percutaneous endoscopy to place syringopleural or cystoperitoneal cerebrospinal fluid shunts: technical note
    James D Guest
    Department of Neurological Surgery, University of Miami, Miami, Florida 33136, USA
    J Neurosurg Spine 2:498-504. 2005
    ..In one case the catheter migrated and required repositioning. Percutaneous endoscopic shunt placement appears feasible in appropriately selected patients...
  24. ncbi Macrocephaly, increased intracranial pressure, and hydrocephalus in the infant and young child
    Alexandra T Vertinsky
    Stanford University Medical Center, Stanford, CA, USA
    Top Magn Reson Imaging 18:31-51. 2007
    ..Imaging guidelines are also outlined for initial evaluation and follow-up, along with a discussion of the imaging features of shunt malfunction...
  25. doi Benign extracerebral fluid collections in infancy: clinical presentation and long-term follow-up
    Leslie C Hellbusch
    Department of Surgery Neurosurgery, Nebraska Medical Center, Omaha, Nebraska 68114, USA
    J Neurosurg 107:119-25. 2007
    ..This study was undertaken to establish head size at birth, head size at presentation, head growth over time, history of presentation, indications for surgery, and long-term results...
  26. ncbi Surgical management of idiopathic normal-pressure hydrocephalus
    Marvin Bergsneider
    Division of Neurosurgery, University of California at Los Angeles Medical Center, Los Angeles, California, USA
    Neurosurgery 57:S29-39; discussion ii-v. 2005
    ..Many earlier studies predated our current understanding of the hydrodynamics of cerebrospinal fluid shunts, and therefore, the conclusions drawn may no longer be valid.
  27. ncbi Randomized, controlled trial of acetazolamide and furosemide in posthemorrhagic ventricular dilation in infancy: follow-up at 1 year
    C R Kennedy
    Department of Pediatric Neurology, Southampton General Hospital, Southampton, England
    Pediatrics 108:597-607. 2001
    ..This article reports a multicenter, randomized, controlled trial designed to test the hypothesis that these drugs would reduce the rate of shunt placement (or death) and increase survival to 1 year of age without disability...
  28. ncbi Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients
    Petra Klinge
    Neurosurgical Department, Medical School Hannover, Hannover, Germany
    Neurosurgery 57:S40-52; discussion ii-v. 2005
    ..Because specific criteria for defining clinical improvement are seldom reported, conclusions drawn about shunt outcome may be subjective...
  29. doi Assessment of idiopathic normal pressure patients in neurological practice: the role of lumbar infusion testing for referral of patients to neurosurgery
    A Brean
    Department of Neurology, Vestfold Country Hospital, Oslo, Norway
    Eur J Neurol 15:605-12. 2008
    ..To retrospectively analyse lumbar infusion tests done in neurological practice in iNPH patients to see how infusion test results relate to the clinical course and shunt response...
  30. doi Longitudinal diffusion-weighted imaging in infants with hydrocephalus: decrease in tissue water diffusion after cerebrospinal fluid diversion
    Paul H Leliefeld
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Neurosurg Pediatr 4:56-63. 2009
    ..The aim of the present study was to investigate whether cerebral edema can be quantified using diffusion-weighted imaging in infants with hydrocephalus and whether CSF diversion could decrease cerebral edema...
  31. ncbi Measurement of cerebrospinal fluid output through external ventricular drainage in one hundred infants and children: correlation with cerebrospinal fluid production
    Takasumi Yasuda
    Division of Pediatric Neurosurgery, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Ill 60614, USA
    Pediatr Neurosurg 36:22-8. 2002
    ..In the present study, hourly CSF outputs in children with hydrocephalus were measured while they were treated with EVD and correlated with the age, sex and body weight of the patients as well as other clinical parameters...
  32. doi Hospital costs associated with shunt infections in patients receiving antibiotic-impregnated shunt catheters versus standard shunt catheters
    Frank J Attenello
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21237, USA
    Neurosurgery 66:284-9; discussion 289. 2010
    ..We set out to determine whether introduction of antibiotic-impregnated shunts (AISs) in our practice has decreased the incidence of shunt infection or decreased infection-related hospital costs at our institution...
  33. ncbi Life expectancy of ventriculosubgaleal shunt revisions
    R Shane Tubbs
    Department of Cell Biology, University of Alabama at Birmingham, Alabama 35233, USA
    Pediatr Neurosurg 38:244-6. 2003
    ..5 months with intermittent subgaleal shunt revisions. In the majority of cases, this length of time is sufficient to manage and resolve issues that would make ventriculoperitoneal shunting undesirable...
  34. doi Do antibiotic-impregnated catheters prevent infection in CSF diversion procedures? Review of the literature
    Raquel Gutiérrez-González
    Department of Neurosurgery, Hospital Universitario Clinico San Carlos, 28040 Madrid, Spain
    J Infect 61:9-20. 2010
    ..Further economic evaluation is required to confirm the benefit in terms of cost-effectiveness as well...
  35. ncbi Lack of efficacy of antibiotic-impregnated shunt systems in preventing shunt infections in children
    Peter Kan
    Department of Neurosurgery, Primary Children s Medical Center, University of Utah, 100 N Medical Drive, Salt Lake City, UT 84113, USA
    Childs Nerv Syst 23:773-7. 2007
    ..We evaluated the incidence of shunt infections associated with the use of AI shunt catheters and compared it with the incidence associated with standard non-AI catheters...
  36. ncbi Rifampin-impregnated silicone catheters: a potential tool for prevention and treatment of CSF shunt infections
    J A Hampl
    Department of Neurosurgery, University of Cologne, Joseph Stelzmann Strasse 9, D 50924 Cologne, Germany
    Infection 31:109-11. 2003
    ..The development of a rifampin-impregnated silicone catheter yielded excellent results in infection prevention and treatment in vitro as well as in an animal model...
  37. ncbi Infection rates in standard vs. hydrogel coated ventricular catheters
    Anthony M Kaufmann
    Section of Neurosurgery, University of Manitoba, Manitoba, MB, Canada
    Can J Neurol Sci 31:506-10. 2004
    ..Modified catheters with a hydrophilic surface may impede bacterial adherence and thereby reduce catheter related cerebrospinal fluid (CSF) infection...
  38. ncbi Initial experience with antibiotic-impregnated silicone catheters for shunting of cerebrospinal fluid in children
    Henry E Aryan
    Division of Neurosurgery, Children s Hospital, San Diego, CA, USA
    Childs Nerv Syst 21:56-61. 2005
    ..However, these shunts are yet to be evaluated in clinical trials and their safety and efficacy in preventing shunt infections is unknown...
  39. pmc Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients
    Rainer Ritz
    Department of Neurosurgery, University Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 7:38. 2007
    ..The study was performed to analyze if AIS can diminish the rate of shunt infection. The pathogenic nature of shunt infection in patients with AIS systems and those without antibiotic impregnated shunts (non-AIS) was compared...
  40. ncbi Predictors of death in pediatric patients requiring cerebrospinal fluid shunts
    Sagun Tuli
    Department of Neurosurgery, The Brigham and Women s Hospital, Harvard Medical School, Brookline, Massachusetts, USA
    J Neurosurg 100:442-6. 2004
    ..The goal of this study was to determine the long-term outcome and predictors of death in these patients...
  41. ncbi Evaluation of an antibiotic-impregnated shunt system for the treatment of hydrocephalus
    Soma T Govender
    Department of Neurosurgery, Wentworth Hospital, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    J Neurosurg 99:831-9. 2003
    ..In this study, the authors assess an AIS system with respect to its prevention of shunt infection...
  42. ncbi Reduction in shunt infection using antibiotic impregnated CSF shunt catheters: an Australian prospective study
    Ananthababu Pattavilakom
    Department of Neurosurgery, Monash Medical Centre, Clayton, Victoria 3168, Australia
    J Clin Neurosci 14:526-31. 2007
    ..This data and the literature support the routine usage of AIC for all CSF shunt procedures...
  43. ncbi Infection of cerebrospinal fluid shunts: causative pathogens, clinical features, and outcomes
    Kuo Wei Wang
    Department of Neurosurgery, Chang Gung Memorial Hospital Kaohsiung, Taiwan
    Jpn J Infect Dis 57:44-8. 2004
    ....
  44. ncbi Prolonged exposure to antibiotic-impregnated shunt catheters does not increase incidence of late shunt infections
    Daniel M Sciubba
    Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8 161, Baltimore MD 21287, USA
    Childs Nerv Syst 23:867-71. 2007
    ..In this study, the authors evaluate the incidence of late shunt infection after the introduction of an AIS system in a pediatric hydrocephalus population...
  45. doi Effects of antibiotic-impregnated external ventricular drains on bacterial culture results: an in vitro analysis
    E Andrew Stevens
    Department of Neurosurgery, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Neurosurg 113:86-92. 2010
    ..The purpose of this study was to assess whether AI EVDs had any significant effect on bacterial culture results compared with nonantibiotic-impregnated (NAI) EVDs...
  46. ncbi The occurrence of obstructive vs absorptive hydrocephalus in newborns and infants: relevance to treatment choices
    Liana Beni-Adani
    Department of Pediatric Neurosurgery, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman St, Tel Aviv, 64239, Israel
    Childs Nerv Syst 22:1543-63. 2006
    ..The objective of this paper is to present the spectrum of obstructive-communicating hydrocephalus, which is more complex in the pediatric group, and to propose the relevance of this particular classification to treatment options...
  47. ncbi Factors contributing to the medical costs of cerebrospinal fluid shunt infection treatment in pediatric patients with standard shunt components compared with those in patients with antibiotic impregnated components
    Daniel M Sciubba
    Department of Neurosurgery, Baltimore, Maryland 21287, USA
    Neurosurg Focus 22:E9. 2007
    ....
  48. ncbi Ventriculosubgaleal shunts for posthemorrhagic hydrocephalus in premature infants
    Brian K Willis
    Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Pediatr Neurosurg 41:178-85. 2005
    ..Ventriculosubgaleal shunts have been recommended as a more physiologic and less invasive means of achieving this goal. We have performed this procedure in 6 premature infants to evaluate their effectiveness and complications...
  49. ncbi Cerebrospinal fluid shunt infection: a prospective study of risk factors
    A V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg 94:195-201. 2001
    ..2) Alternatives to placement of a CSF shunt in premature infants should be studied. 3) Surgeons should minimize manual contact with the shunt system and consider the use of double gloves...
  50. ncbi [Effect of antibiotic-impregnated catheters on the incidence of infection after cerebrospinal fluid shunting]
    Raquel Gutiérrez-González
    Servicio de Neurocirugia, Hospital Clinico San Carlos, Madrid, Espana
    Med Clin (Barc) 131:121-4. 2008
    ..The objective of this study was to determine if the use of AI catheters reduces Staphylococcus spp. infection rate, as it is the most commonly isolated organism...
  51. ncbi Alternatives to shunting
    G Cinalli
    Department of Pediatric Neurosurgery, Santobono Hospital, Naples, Italy
    Childs Nerv Syst 15:718-31. 1999
    ....
  52. doi Antibiotic-impregnated shunt catheters for the treatment of infantile hydrocephalus
    Daniel M Sciubba
    Department of Pediatric Neurological Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
    Pediatr Neurosurg 44:91-6. 2008
    ..In this study, clinical outcomes were assessed in infants with hydrocephalus (<1 year) following AIS placement...
  53. ncbi Management of shunt infections: a multicenter pilot study
    John R W Kestle
    Department of Neurosurgery, Primary Children s Medical Center, University of Utah, Salt Lake City, Utah 84113, USA
    J Neurosurg 105:177-81. 2006
    ..The present multicenter pilot study was undertaken to evaluate current strategies in the treatment of shunt infection...
  54. ncbi Does lumbar cerebrospinal fluid reflect ventricular cerebrospinal fluid? A prospective study in patients with external ventricular drainage
    Jan B Sommer
    Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Eur Neurol 47:224-32. 2002
    ....
  55. ncbi The impact of antibiotic-impregnated catheters on shunt infection in children and neonates
    Caroline Hayhurst
    Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Childs Nerv Syst 24:557-62. 2008
    ..We evaluate the impact on infection rates in children following the introduction of catheters impregnated with rifampicin and clindamycin...
  56. doi Comparison of shunt infection incidence in high-risk subgroups receiving antibiotic-impregnated versus standard shunts
    Scott L Parker
    Department of Neurosurgery, The Johns Hopkins Hospital, 600 N Wolfe Street, Harvey 811, Baltimore, MD 21287, USA
    Childs Nerv Syst 25:77-83; discussion 85. 2009
    ..We set out to determine whether the categorical switch to AIS systems at our institution has resulted in a decreased incidence of shunt infection in high-risk pediatric patients...
  57. doi Infection rate with application of an antibiotic-impregnated catheter for shunt implantation in children - a retrospective analysis
    R Eymann
    Department of Neurosurgery, Saarland University, Homburg Saar, Germany
    Klin Padiatr 221:69-73. 2009
    ..An antibiotic impregnated shunt-catheter (AIS) was designed to reduce the incidence of shunt infections...
  58. doi Efficacy of antibiotic-impregnated shunt catheters in reducing shunt infection: data from the United Kingdom Shunt Registry
    Hugh K Richards
    United Kingdom Shunt Registry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg Pediatr 4:389-93. 2009
    ..The authors used data collected by the UK Shunt Registry to assess the efficacy of antibiotic-impregnated catheters (AICs) against shunt infection by using a matched-pair study design...
  59. ncbi Duration of in vivo antimicrobial activity of antibiotic-impregnated cerebrospinal fluid catheters
    Ananthababu Pattavilakom
    Department of Neurosurgery, Monash Medical Centre, Clayton, Australia
    Neurosurgery 58:930-5; discussion 930-5. 2006
    ..We aim to study the longevity of antimicrobial activity of AIC in vivo by using explanted catheters...
  60. ncbi Laparoscopic and thoracoscopic assistance with CSF shunts in children
    G W Holcomb
    Department of Surgery, Children s Hospital, Vanderbilt University Medical Center, Nashville, TN, USA
    J Pediatr Surg 30:1642-3. 1995
    ..Thoracoscopy for a syringopleural shunt prevents the need for minithoracotomy...
  61. ncbi Mode of action of an antimicrobial biomaterial for use in hydrocephalus shunts
    Roger Bayston
    Biomaterials Related Infection Group, Division of Orthopaedic and Accident Surgery, C Floor West Block, University Hospital, Nottingham NG7 2UH, UK
    J Antimicrob Chemother 53:778-82. 2004
    ..As there is no clear evidence to support antibiotic prophylaxis, we have developed an impregnated antimicrobial shunt material. This study aimed to elucidate its mode of action in terms of bacterial adherence and killing kinetics...
  62. ncbi Antibiotic prophylaxis in cerebrospinal fluid shunting: a prospective randomized trial in 129 patients
    J Zentner
    Department of Neurosurgery, University of Bonn, Rep of Germany
    Neurosurg Rev 18:169-72. 1995
    ..Therefore, we favor single dose antibiotic prophylaxis in shunting procedures...
  63. ncbi Effect of antibiotic-impregnated shunt catheters in decreasing the incidence of shunt infection in the treatment of hydrocephalus
    Daniel M Sciubba
    Department of Neurosurgery and Division of Pediatric Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosurg 103:131-6. 2005
    ..In this study, the authors evaluate the incidence of shunt infection after introduction of an AIS system in a population of children with hydrocephalus...
  64. ncbi Pseudotumor cerebri patients with shunts from the cisterna magna: clinical course and telemetric intracranial pressure data
    Max C Lee
    Section of Neurosurgery, Department of Surgery, University of Chicago Hospitals and Pritzker School of Medicine, Chicago, Illinois, USA
    Neurosurgery 55:1094-9. 2004
    ..We have encountered several such patients and describe our strategy of shunting from the cisterna magna to the pleural space or cardiac atrium...
  65. pmc Laparoscopic-assisted lumboperitoneal shunt: a simplified technique
    S Johna
    Department of Surgery, Loma Linda University School of Medicine, CA 92354, USA
    JSLS 5:305-7. 2001
    ..The procedure can be performed in less than 30 minutes by any practicing laparoscopist...
  66. ncbi Endoscopic implantation and patency evaluation of lumboperitoneal shunt: an innovative technique
    S A Hay
    Department of General Surgery, Faculty of Medicine, Ain Shams University, 1 El Mokades El Kabary Street, 7th District, Nasr City, Cairo, Egypt
    Surg Endosc 18:482-4. 2004
    ....
  67. doi Endoscopic cyst fenestration in the treatment of multiloculated hydrocephalus in children
    Nasser M F El-Ghandour
    Department of Neurosurgery, Cairo University, Cairo, Egypt
    J Neurosurg Pediatr 1:217-22. 2008
    ..Definitive treatment is surgical, yet the approach remains controversial. The author has therefore reviewed his results with endoscopic cyst fenestration (ECF) in the management of this disease...
  68. doi Cerebrospinal fluid dynamics: disturbances and diagnostics
    A Lavinio
    Addenbrooke s Hospital, Academic Neurosurgery, Cambridge, UK
    Eur J Anaesthesiol Suppl 42:137-41. 2008
    ..The technique is also helpful in the assessment of shunt malfunction, including posture-related over-drainage and shunt obstruction...
  69. doi Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths
    Tamara D Simon
    Department of Pediatrics, Division of Inpatient Medicine, University of Utah, Salt Lake City, Utah 84113, USA
    J Neurosurg Pediatr 1:131-7. 2008
    ....
  70. doi Have we made progress in preventing shunt failure? A critical analysis
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19106, USA
    J Neurosurg Pediatr 1:40-7. 2008
    ..The goal of this study was to determine whether failure rates of hydrocephalus shunts have fallen over the years as a result of experience or technical improvements...
  71. ncbi Treatment of suprasellar cysts and patient outcome
    Darach William Crimmins
    Department of Pediatric Neurosurgery, Hopital Necker Enfants Malades, Paris, France
    J Neurosurg 105:107-14. 2006
    ..The authors sought to determine the natural history of and optimal treatment for suprasellar cysts (SSCs)...
  72. ncbi Long-term outcome of endoscopic third ventriculostomy in obstructive hydrocephalus
    M Gangemi
    Department of Neurological Sciences, Neurosurgical Clinic, Federico II University, Naples, Italy
    Minim Invasive Neurosurg 50:265-9. 2007
    ..Because postoperative failures occur early, clinical and radiological control studies must be performed particularly in the first years after the neuroendoscopic procedure...
  73. ncbi [Nursing care of children with a cerebrospinal fluid shunt]
    Monika Bauer
    Kinderklinik München Schwabing, Chirurgische Wach und Intensivstation, Munchen
    Kinderkrankenschwester 21:150-4. 2002
  74. ncbi Etiological differences between the isolated lateral ventricle and the isolated fourth ventricle
    Beng Ti Ang
    Department of Pediatric Surgery, Division of Pediatric Neurosurgery, British Columbia Children s Hospital, 4480 Oak Street, K 3 159, Vancouver, British Columbia, V6H 3V4, Canada
    Childs Nerv Syst 22:1080-5. 2006
    ..To determine if an etiological difference exists between isolation of the lateral ventricle and isolation of the fourth ventricle after ventricular shunting...
  75. doi Apparent diffusion coefficient and cerebrospinal fluid flow measurements in patients with hydrocephalus
    Yonca Anik
    Department of Radiology, School of Medicine, Kocaeli University, Umuttepe, Kocaeli, Turkey
    J Comput Assist Tomogr 32:392-6. 2008
    ..To evaluate the efficacy of diffusion magnetic resonance imaging and compare with cerebrospinal fluid (CSF) flow imaging in patients with hydrocephalus before and after treatment...
  76. doi Neuroendoscopic procedures in achievement of shunt independence: outcome analysis of 28 patients with shunt malfunction
    A Sufianov
    Russian Academy of Medical Sciences, East Siberian Minimally Invasive Neurosurgical Centre, Irkutsk, Russia sufi
    Minim Invasive Neurosurg 51:158-64. 2008
    ..The authors review their experience of the TV-controlled endoscopic technique in the treatment of shunt malfunction in 28 patients suffering from hydrocephalus...
  77. doi Retrieval of ventricular catheter with the aid of endoscopy: technical note
    Benedetta Ludovica Pettorini
    Institute of Neurosurgery, Division of Pediatric Neurosurgery, Catholic University of Rome, Rome, Italy
    J Neurosurg Pediatr 2:71-4. 2008
    ..The removal of an unnecessary and no longer useful prosthetic device that is a possible focus of infection justifies endoscopic treatment, which, in this experience, is not associated with morbidity...
  78. doi Cranial vault expansion in the management of postshunt craniosynostosis and slit ventricle syndrome
    Jeffrey Weinzweig
    Division of Plastic Surgery, The Children s Hospital of Philadelphia, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Plast Reconstr Surg 122:1171-80. 2008
    ..Excessive intracranial decompression may result in ventricular collapse with the formation of slit-like ventricles and cranial vault collapse with secondary craniosynostosis...
  79. ncbi Endoscopic third ventriculostomy for tumor-related hydrocephalus in a pediatric population
    Pulak Ray
    Division of Pediatric Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Neurosurg Focus 19:E8. 2005
    ..Nevertheless, there is still controversy regarding the indications for ETV as the primary procedure, given its variable success rates. The purpose of this study is to review the authors' experience with ETV for a variety of patients...
  80. ncbi Frontal and occipital horn width ratio for the evaluation of small and asymmetrical ventricles
    Mohammad Jamous
    Department of Neurological Surgery, Children s Hospital of Michigan, Detroit Medical Center, 48201, USA
    Pediatr Neurosurg 39:17-21. 2003
    ..FOHWR showed better correlation with ventricular size and ventricular brain ratio than the ventricular linear measurements currently in use, especially in chronically shunted patients with small and/or asymmetrical ventricles...
  81. ncbi Treatment of cerebrospinal fluid shunting complications in a Nigerian neurosurgery programme. Case illustrations and review
    Edward O Komolafe
    Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria
    Pediatr Neurosurg 44:36-42. 2008
    ..The aim of this paper was to present our experience with the treatment of hydrocephalus in our centre and highlight our management of two unusual complications with the available resources...
  82. ncbi Evaluation of the necessity of postoperative imaging after craniosynostosis surgery
    Mandy Binning
    Department of Neurosurgery, Primary Children s Medical Center, University of Utah, Salt Lake City, Utah 84113, USA
    J Neurosurg 107:43-5. 2007
    ..The object of this study was to evaluate the utility of these scans...
  83. ncbi First experiences with a 2.0-microm near infrared laser system for neuroendoscopy
    H C Ludwig
    Department of Neurosurgery, Medical School and University Hospital, Georg August University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Neurosurg Rev 30:195-201; discussion 201. 2007
    ..There was neither mortality nor transient or permanent morbidity. The authors conclude that the use of the 2.0-microm near infrared laser enables safe and effective procedures in neuroendoscopy...
  84. ncbi Management of hydrocephalus in children with posterior fossa tumors: role of tumor surgery
    Bernt Johan Due-Tønnessen
    Department of Neurosurgery, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Pediatr Neurosurg 43:92-6. 2007
    ..There is no consensus regarding the management of HC in these children. Here, we report the rate of cure of HC with tumor surgery alone...
  85. ncbi Experience with the Strata valve in the management of shunt overdrainage
    Charles Kondageski
    Department of Pediatric Neurosurgery, Great Ormond Street Hospital for Children, London, United Kingdom
    J Neurosurg 106:95-102. 2007
    ..Externally adjustable valves offer a noninvasive way of altering the valve opening pressure. The authors report on their experience with using the Strata valve in the management of symptomatic CSF overdrainage...
  86. ncbi Endoscopic third ventriculocisternostomy for brainstem tumors
    Paul Klimo
    Department of Neurosurgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosurg 105:271-4. 2006
    ..The authors retrospectively reviewed the charts of all patients harboring brainstem tumors treated at their institution, excluding those with tectal gliomas, who underwent an endoscopic third ventriculocisternostomy...
  87. ncbi Treatment options for Dandy-Walker malformation
    Aaron Mohanty
    Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    J Neurosurg 105:348-56. 2006
    ..The aim of this study was to assess the efficacy of various treatment options available for children with Dandy-Walker malformation (DWM) and to evaluate the role of endoscopic procedures in the treatment of this disorder...
  88. ncbi Progressive myelopathy due to meningeal thickening in shunted patients: description of a novel entity and the role of surgery
    Matthieu Vinchon
    Department of Pediatric Neurosurgery, Hopital Roger Salengro, 59037, Lille Cedex, France
    Childs Nerv Syst 23:839-45. 2007
    ..Spinal cord compression due to meningeal thickening is a rare occurrence in shunted patients. Because of the long delay to clinical onset, this complication has not been identified as yet...
  89. ncbi Outcomes after decompressive craniectomy for severe traumatic brain injury in children
    Peter Kan
    Department of Neurosurgery, Primary Children s Medical Center, University of Utah, Salt Lake City, Utah 84113 1100, USA
    J Neurosurg 105:337-42. 2006
    ..In this paper the authors evaluate mortality and morbidity and long-term outcomes in children who underwent decompressive craniectomy for severe TBI at a single institution...
  90. ncbi Is endoscopic third ventriculostomy an internal shunt alone?
    M Gangemi
    Department of Neurological Sciences, Section of Neurosurgery, Federico II University School of Medicine, Naples, Italy
    Minim Invasive Neurosurg 50:47-50. 2007
    ..This study was made to define the mechanism of endoscopic third ventriculostomy (ETV) in the various forms of hydrocephalus...
  91. ncbi Neuroinfections complicating foreign body implants after perinatal trauma or meningitis in 60 children
    B Rudinsky
    School of Medicine and School of Health, Department of Neurology, Bratislava, Kosice, Banska Bystrica, Nitra, Slovakia
    Neuro Endocrinol Lett 28:36-7. 2007
    ..aeruginosa than other organisms and was significantly associated with perinatal trauma, hydrocephalus, haemorrhage or VLBW and had more neurologic sequels despite mortality was similar to other nosocomial meningitis...
  92. ncbi Adjustable vs set-pressure valves decrease the risk of proximal shunt obstruction in the treatment of pediatric hydrocephalus
    Matthew J McGirt
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8 161, Baltimore, MD 21287, USA
    Childs Nerv Syst 23:289-95. 2007
    ..The use of programmable shunt valves has increased dramatically in the practice of pediatric hydrocephalus. Despite theoretical advantages, it remains unclear if the use of programmable vs set-pressure valves affects shunt outcome...
  93. ncbi Endoscopic biopsy for intraventricular tumors in children
    Bart Depreitere
    Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 106:340-6. 2007
    ..The authors performed a retrospective analysis of biopsy accuracy, complication rate, and success rate of ETV in a series of 31 endoscopic biopsy procedures...
  94. ncbi Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: variations of the same theme
    Rajeev Kariyattil
    Division of Pediatric Neurosurgery, Department of Pediatric Surgery, British Columbia Children s Hospital, Children s and Women s Health Centre, Vancouver, British Columbia, Canada
    J Neurosurg 106:350-3. 2007
    ..Although various factors have been implicated, the exact pathogenesis of the two conditions remains elusive. To the authors' knowledge, there are no studies in which these two obviously related conditions have been compared...
  95. ncbi Treatment of hydrocephalus with functionally isolated ventricles
    B Atalay
    Department of Neurosurgery, Baskent University, Ankara, Turkey
    Acta Neurochir (Wien) 148:1293-6; discussion 1296. 2006
    ....
  96. ncbi The Strata programmable valve for shunt-dependent hydrocephalus: the pediatric experience at a single institution
    Edward S Ahn
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Childs Nerv Syst 23:297-303. 2007
    ..The objective of this study was to examine its efficacy during our initial experience with it in shunt-dependent children...
  97. ncbi Thalamic tumors in children: a reappraisal
    Stephanie Puget
    Department of Pediatric Neurosurgery, Hopital Necker Enfants Malades, Paris, France
    J Neurosurg 106:354-62. 2007
    ..The aim of this study was to determine whether clinical and neuroimaging features could guide treatment, and to what extent these features, together with histological diagnosis and treatment modalities, influenced survival...
  98. ncbi Shunt-related craniocerebral disproportion: treatment with cranial vault expanding procedures
    Juan F Martínez-Lage
    Regional Service of Neurosurgery and Unit of Pediatric Neurosurgery, Virgen de la Arrixaca University Hospital, El Palmar, 30120, Murcia, Spain
    Neurosurg Rev 29:229-35. 2006
    ....
  99. ncbi Use of rapid-sequence magnetic resonance imaging for evaluation of hydrocephalus in children
    William W Ashley
    Department of Neurosurgery, St Louis Children s Hospital, Missouri 63110 1077, USA
    J Neurosurg 103:124-30. 2005
    ..Standard MR imaging provides greater structural resolution, yet visualization of ventricular catheters is relatively poor...
  100. ncbi Do adjustable shunt valves pressure our budget? A retrospective analysis of 541 implanted Codman Hakim programmable valves
    G Zemack
    Department of Clinical Neuroscience, Division of Neurosurgery, Lund University Hospital, Lund, Sweden
    Br J Neurosurg 15:221-7. 2001
    ..The analysis suggests that the extra cost of the valve is outweighed by the ability to adjust the opening pressure setting non-invasively...
  101. ncbi CSF shunt removal in children with hydrocephalus
    A Iannelli
    Institute of Neurosurgery, Section of Paediatric Neurosurgery, University of Pisa, Pisa, Italy
    Acta Neurochir (Wien) 147:503-7; discussion 507. 2005
    ..The same constraint prevents the evaluation of the actual overall incidence of shunt independence in shunted hydrocephalic children, as some of them could have harboured a non-functioning CSF shunt device, though unnoticed...

Research Grants89

  1. A novel in vitro model of thyroid ophthalmopathy
    Steven Feldon; Fiscal Year: 2005
    ..abstract_text> ..
  2. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
    ..The results may have important public health implications in that improved understanding of the pathological consequences of cerebral amyloid deposition may lead to medical treatments that will improve outcome following TBI. ..
  3. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
    ..An improved understanding of these disorders will offer new and better treatment modalities for millions of affected patients. ..
  4. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2006
    ..At the study conclusion, derived data should also practically affect the surgical choice of shunting products. ..
  5. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2007
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..
  6. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
    ..Taken in concert, these studies will provide a more indepth understanding of the role of aquaporins in brain injury and introduce novel therapeutic approaches for treating brain edema. ..
  7. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..
  8. Quantitative MR measure of MTX neurotoxicity in children
    WILBURN REDDICK; Fiscal Year: 2006
    ....
  9. World Workshop in Oral Medicine IV
    Peter Lockhart; Fiscal Year: 2005
    ..The proceedings will be published as evidence-based recommendations for best clinical practice in Oral Medicine as well as providing suggestions for future basic science and clinical research. ..
  10. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004
    ..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
  11. Multicenter Trial of Fetal Myelomeningocele Repair
    N Adzick; Fiscal Year: 2006
    ..In summary, the proposed trial is expected to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..
  12. Folic Acid Enhances Repair Mechanism in the Adult CNS
    Bermans J Iskandar; Fiscal Year: 2010
    ....
  13. Studying models and mechanisms of optic nerve diseases
    Donald Hood; Fiscal Year: 2009
    ..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..
  14. Control of Genomic Stability by Emi1 and Securin
    NORMAN LEHMAN; Fiscal Year: 2007
    ..abstract_text> ..
  15. Pilot Randomized, Double-Blind Crossover Study of Fish Oil [EPA and DHA] For Intr
    Christopher DeGiorgio; Fiscal Year: 2007
    ..The purpose of this study is to investigate whether omega-3 fatty acids (as fish oil) benefit people with epilepsy by reducing seizures, preventing sudden death, and improving memory and thinking processes. ..
  16. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2007
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  17. Studying models and mechanisms of optic nerve diseases
    Donald Hood; Fiscal Year: 2007
    ..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..
  18. Improving Follow-up After an Emergency Visit for Asthma
    Joseph Zorc; Fiscal Year: 2007
    ..The expected goal of the project will be to develop an intervention that can subsequently be tested in a newly developed, federally-funded research network of pediatric EDs. ..
  19. MEASURE OF RECEPTOR AND POST RECEPTOR ACTIVITY
    Donald Hood; Fiscal Year: 2002
    ..monkeys in which INL activity is pharmacologically dissected, b. normal human subjects, c. patients with disease of the INL, and d. mathematical work. ..
  20. PREDICTING DELAYED CEREBRAL ISCHEMIA IN SAH
    Mary Kerr; Fiscal Year: 2002
    ....
  21. Measures of Human Receptor and Post Receptor Activity
    Donald C Hood; Fiscal Year: 2010
    ..These same techniques can enable the ophthalmologist to monitor the health of these cells and, thus the effectiveness of alternative treatments. ..
  22. Tests of Models of Retinal/Optic Nerve Diseases&Adaption
    Donald Hood; Fiscal Year: 2004
    ..Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON). ..
  23. TESTS OF MODELS OF RETINAL DISEASE ADAPTATION
    Donald Hood; Fiscal Year: 2000
    ..This could be especially valuable in assessing retinal function of patients with heterogeneous damage as in retinitis pigmentosa, diabetic retinopathy, and glaucoma. ..
  24. MEASURE OF HUMAN RECEPTOR AND POST-RECEPTOR ACTIVITY
    Donald Hood; Fiscal Year: 1993
    ..Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors...
  25. TESTS OF MODELS OF RETINAL DISEASE AND ADAPTATION
    Donald Hood; Fiscal Year: 1993
    ..The data will be analyzed within the context of recent models of cone systems, models based on recent physiology...
  26. Measures of Human Receptor and Post Receptor Activity
    Donald Hood; Fiscal Year: 2007
    ..We propose as part of aim 3 to improve our understanding of these relationships as well as to improve our analysis of visual field data. ..
  27. Macrophage and Microglial Activation in Glioma-Associated Inflammation
    Nalin Gupta; Fiscal Year: 2007
    ..Another possible benefit of such drugs is that normal tissue injury associated with treatments such as radiation may also be reduced. ..
  28. TESTS OF MODELS OF RETINAL DISEASE AND ADAPTATION
    Donald Hood; Fiscal Year: 1991
    ..Finally, we intend to obtain a better understanding of the relative involvement of the rod and different cone mechanisms in retinitis pigmentosa and in progressive cone dystrophy...