heart valve prosthesis implantation

Summary

Summary: Surgical insertion of synthetic material to repair injured or diseased heart valves.

Top Publications

  1. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  2. doi Transcatheter versus surgical aortic-valve replacement in high-risk patients
    Craig R Smith
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 364:2187-98. 2011
  3. doi Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery
    Martin B Leon
    Columbia University Medical Center NewYork Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 363:1597-607. 2010
  4. doi Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis
    Corrado Tamburino
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Circulation 123:299-308. 2011
  5. doi Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry
    Helene Eltchaninoff
    Cardiology Department, Charles Nicolle Hospital, University of Rouen INSERM U644, 1 rue de Germont, Rouen Cedex, France
    Eur Heart J 32:191-7. 2011
  6. doi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
  7. ncbi Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    Circulation 106:3006-8. 2002
  8. pmc Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
    Eur Heart J 32:205-17. 2011
  9. doi Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 55:1080-90. 2010
  10. pmc One year follow-up of the multi-centre European PARTNER transcatheter heart valve study
    Thierry Lefevre
    Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy, France
    Eur Heart J 32:148-57. 2011

Detail Information

Publications279 found, 100 shown here

  1. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  2. doi Transcatheter versus surgical aortic-valve replacement in high-risk patients
    Craig R Smith
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 364:2187-98. 2011
    ..However, the two procedures have not been compared in a randomized trial involving high-risk patients who are still candidates for surgical replacement...
  3. doi Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery
    Martin B Leon
    Columbia University Medical Center NewYork Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 363:1597-607. 2010
    ..Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment for high-risk patients with aortic stenosis...
  4. doi Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis
    Corrado Tamburino
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Circulation 123:299-308. 2011
    ....
  5. doi Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry
    Helene Eltchaninoff
    Cardiology Department, Charles Nicolle Hospital, University of Rouen INSERM U644, 1 rue de Germont, Rouen Cedex, France
    Eur Heart J 32:191-7. 2011
    ....
  6. doi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry...
  7. ncbi Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    Circulation 106:3006-8. 2002
    ..Valve replacement had been declined for this patient, and balloon valvuloplasty had been performed with nonsustained results...
  8. pmc Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
    Eur Heart J 32:205-17. 2011
    ..To make these consensus definitions accessible to all stakeholders in TAVI clinical research through a peer reviewed publication, on behalf of the public health...
  9. doi Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 55:1080-90. 2010
    ....
  10. pmc One year follow-up of the multi-centre European PARTNER transcatheter heart valve study
    Thierry Lefevre
    Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy, France
    Eur Heart J 32:148-57. 2011
    ..Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option in high-risk patients with severe aortic stenosis...
  11. doi Percutaneous repair or surgery for mitral regurgitation
    Ted Feldman
    Evanston Hospital, NorthShore University Health System, Evanston, IL 60201, USA
    N Engl J Med 364:1395-406. 2011
    ..Mitral-valve repair can be accomplished with an investigational procedure that involves the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet...
  12. doi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
    ..The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008...
  13. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported...
  14. doi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
    ..Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known...
  15. doi Two-year outcomes after transcatheter or surgical aortic-valve replacement
    Susheel K Kodali
    Columbia University Medical Center and New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 366:1686-95. 2012
    ..However, longer-term follow-up is necessary to determine whether TAVR has prolonged benefits...
  16. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    ....
  17. doi Multimodal assessment of the aortic annulus diameter: implications for transcatheter aortic valve implantation
    David Messika-Zeitoun
    INSERM, U698, University Paris 7, Paris, France
    J Am Coll Cardiol 55:186-94. 2010
    ....
  18. doi Comparison between Society of Thoracic Surgeons score and logistic EuroSCORE for predicting mortality in patients referred for transcatheter aortic valve implantation
    Itsik Ben-Dor
    Interventional Cardiology, Washington Hospital Center, Washington, DC 20010, USA
    Cardiovasc Revasc Med 12:345-9. 2011
    ..We aimed to examine the correlation between STS and logistic EuroSCOREs and their performance characteristics in patients referred for TAVI...
  19. doi Transcatheter aortic valve implantation for high-risk patients with severe aortic stenosis: A systematic review
    Tristan D Yan
    Department of Cardiothoracic Surgery, The University of Sydney, Royal Prince Alfred Hospital, Sydney 2050, Australia
    J Thorac Cardiovasc Surg 139:1519-28. 2010
    ..The present systematic review objectively assessed the safety and clinical effectiveness of transcatheter aortic valve implantation for patients at high surgical risk with severe aortic stenosis...
  20. doi Percutaneous transarterial aortic valve implantation: what do we know?
    John Webb
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Heart J 32:140-7. 2011
    ..Nevertheless considerable work needs to be done before the indications for TAVI are expanded into lower risk groups. We review what is currently known about percutaneous transarterial implantation of the aortic valve...
  21. doi Registry of transcatheter aortic-valve implantation in high-risk patients
    Martine Gilard
    Centre Hospitalier Universitaire CHU Brest, Brest, France
    N Engl J Med 366:1705-15. 2012
    ..We report the results of a prospective multicenter study of the French national transcatheter aortic-valve implantation registry, FRANCE 2...
  22. doi Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative)
    M Z Khawaja
    UK CoreValve Collaborative, Sussex Cardiac Centre, Brighton and Sussex University Hospital Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, UK
    Circulation 123:951-60. 2011
    ..We assessed the UK incidence of permanent pacing within 30 days of CoreValve implantation and formulated an anatomic and electrophysiological model...
  23. doi Prosthesis-patient mismatch: an update
    Jean G Dumesnil
    Quebec Heart and Lung Institute, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada G1V 4G5
    Curr Cardiol Rep 13:250-7. 2011
    ..Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation...
  24. pmc Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement
    Rodrigo Bagur
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada G1V 4G5
    Eur Heart J 31:865-74. 2010
    ..surgical aortic valve replacement (SAVR) in patients with pre-procedural chronic kidney disease (CKD)...
  25. doi The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2--isolated valve surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Ann Thorac Surg 88:S23-42. 2009
    ..Expanding upon existing valve models, the new STS models include several nonfatal complications in addition to mortality...
  26. doi Aortic annulus evaluation in transcatheter aortic valve implantation
    Andrea Hutter
    Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
    Catheter Cardiovasc Interv 76:1009-19. 2010
    ..We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI)...
  27. doi Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percu
    Alec Vahanian
    Hopital Bichat, Paris, France
    Eur Heart J 29:1463-70. 2008
    ..To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development...
  28. doi Transapical versus transfemoral aortic valve implantation: a comparison of survival and safety
    Malin Johansson
    Department of Cardiothoracic Surgery, Cardiothoracic Anesthesia and Intensive Care, Skåne University Hospital and Lund University, Lund, Sweden
    Ann Thorac Surg 91:57-63. 2011
    ..We aimed to evaluate access-related complications between the transfemoral (TF) and the transapical (TA) approach and to compare survival between TAVI and conventional AVR in propensity-score-matched patients...
  29. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  30. ncbi Dilation of the pulmonary autograft after the Ross procedure
    T E David
    Divisions of Cardiovascular Surgery and Cardiology of Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 119:210-20. 2000
    ..Dilation of pulmonary autograft after the Ross procedure is being recognized with increasing frequency. This study was undertaken to examine the extent of this problem and factors that may be associated with it...
  31. doi Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography
    Arnold C T Ng
    Department of Cardiology, The Department of Cardiothoracic Surgery, and the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Circ Cardiovasc Imaging 3:94-102. 2010
    ..We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI)...
  32. doi Aortic valve replacement in octogenarians: utility of risk stratification with EuroSCORE
    Sergey Leontyev
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 87:1440-5. 2009
    ..We evaluated characteristics and outcomes of elderly patients undergoing isolated AVR with a particular focus on the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk stratification...
  33. doi Noninvasive evaluation of the aortic root with multislice computed tomography implications for transcatheter aortic valve replacement
    Laurens F Tops
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    JACC Cardiovasc Imaging 1:321-30. 2008
    ..In the present study, the anatomy of the aortic root was assessed noninvasively with multislice computed tomography (MSCT)...
  34. doi Biventricular response after pulmonary valve replacement for right ventricular outflow tract dysfunction: is age a predictor of outcome?
    Alessandra Frigiola
    Cardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Circulation 118:S182-90. 2008
    ..We wanted to assess the determinants of improvement after PVR for pulmonary regurgitation over a wide range of patient ages and to use any identified predictors to compare clinical outcomes between patient groups...
  35. ncbi Observed and relative survival after aortic valve replacement
    P Kvidal
    Department of Cardiology, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 35:747-56. 2000
    ..We sought to evaluate the effects of a number of factors that can potentially determine the optimal time for aortic valve replacement (AVR) and the observed and relative survival after the operation...
  36. doi Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
    ..Transapical aortic valve implantation is a new minimally invasive technique for beating heart, off-pump, aortic valve implantation in high-risk patients...
  37. ncbi Alpha-Gal on bioprostheses: xenograft immune response in cardiac surgery
    K Z Konakci
    Medizinische Universität Wien, Vienna, Austria
    Eur J Clin Invest 35:17-23. 2005
    ..We sought to investigate whether a specific alpha-Gal immune response may play a role in this clinical scenario...
  38. doi Role of echocardiography in percutaneous aortic valve implantation
    Robert R Moss
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    JACC Cardiovasc Imaging 1:15-24. 2008
    ..This study was designed to investigate the usefulness and limitations of echocardiography in optimizing the outcome of percutaneous aortic valve implantation...
  39. ncbi Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair
    A L Knauth
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart 94:211-6. 2008
    ..Factors associated with impaired clinical status in a cross-sectional study of patients with repaired tetralogy of Fallot (TOF) have been reported previously...
  40. ncbi Left thoracotomy for aortic and mitral valve surgery in a case of mediastinal displacement due to pneumonectomy
    Theodoro Barreda
    Departement de Chirurgie Cardiovasculaire, Institut de Cardiologie, Hopital Pitie Salpetriere, Paris, France
    J Heart Valve Dis 17:239-42. 2008
    ..Three weeks later, the patient had recovered a normal hemodynamic and spontaneous breathing. A left thoracotomy should be considered as an alternative approach for valve surgery in case of severe heart displacement...
  41. doi Risk scores for predicting outcomes in valvular heart disease: how useful?
    Michael J Mack
    Baylor Health Care System, The Heart Hospital Baylor Plano, TX 75093, USA
    Curr Cardiol Rep 13:107-12. 2011
    ..Ultimately, a new risk algorithm specific for TAVI will need to be developed once sufficient databases are developed...
  42. doi Procedural, 30-day and one year outcome following CoreValve or Edwards transcatheter aortic valve implantation: results of the Belgian national registry
    Johan M Bosmans
    Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Antwerp, Belgium
    Interact Cardiovasc Thorac Surg 12:762-7. 2011
    ..This mid-term mortality was mainly related to age-related, non-cardiac complications...
  43. doi Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percu
    Alec Vahanian
    Hopital Bichat, Paris, France
    Eur J Cardiothorac Surg 34:1-8. 2008
    ..To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development...
  44. doi EuroSCORE overestimates the risk of cardiac surgery: results from the national registry of the German Society of Thoracic and Cardiovascular Surgery
    J F Gummert
    Direktor der Klinik für Thorax und Kardiovaskularchirurgie, Herz und Diabeteszentrum Nordrhein Westfalen, Universitätsklinik der Ruhruniversität Bochum, Bad Oeynhausen, Germany
    Clin Res Cardiol 98:363-9. 2009
    ..Several studies with relatively small patient numbers showed a substantial overestimation of risk by the EuroSCORE. The aim of our study was to evaluate whether the nationwide data support this finding...
  45. doi The acute hemodynamic effects of MitraClip therapy
    Robert J Siegel
    Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 1804, USA
    J Am Coll Cardiol 57:1658-65. 2011
    ..The objective of this study was to evaluate the acute hemodynamic consequences of mitral valve (MV) repair with the MitraClip device (Abbott Vascular, Menlo Park, California)...
  46. doi Transcatheter aortic valve implantation: lessons from the learning curve of the first 270 high-risk patients
    Ronen Gurvitch
    Department of Cardiology and Cardiothoracic Surgery, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Catheter Cardiovasc Interv 78:977-84. 2011
    ..Transcatheter aortic valve implantation (TAVI) is a rapidly evolving strategy for therapy of aortic stenosis. We describe the effect of the learning curve from the first 270 high-risk patients in Vancouver, Canada...
  47. doi Dual antiplatelet therapy versus aspirin alone in patients undergoing transcatheter aortic valve implantation
    Gian Paolo Ussia
    Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy
    Am J Cardiol 108:1772-6. 2011
    ..71) and 6 months (18% vs 15%; p = 0.85). In conclusion, the strategy of adding clopidogrel to aspirin for 3 months after TAVI was not found to be superior to aspirin alone. These results must be confirmed in a larger randomized trial...
  48. doi Comparison of two-dimensional and three-dimensional imaging techniques for measurement of aortic annulus diameters before transcatheter aortic valve implantation
    Ertunc Altiok
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Heart 97:1578-84. 2011
    ..This study sought to compare different 2D and 3D imaging techniques and determine the accuracy of 3D transoesophageal echocardiography (TEE) for accurate analysis of aortic annulus dimensions...
  49. doi Chronic ischaemic mitral regurgitation. Current treatment results and new mechanism-based surgical approaches
    Wobbe Bouma
    Department of Cardiothoracic Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Cardiothorac Surg 37:170-85. 2010
    ..Although promising, at this point these new procedures still lack investigation in large patient cohorts with long-term follow-up. They will, however, be the subject of much anticipated and necessary ongoing and future research...
  50. doi Transcatheter aortic valve implantation: evidence on safety and efficacy compared with medical therapy. A systematic review of current literature
    L Figulla
    Department of Cardiology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Clin Res Cardiol 100:265-76. 2011
    ..In this work, the methodology was applied to provide objective evidence on the efficacy and safety of TAVI at 1-year follow-up and to assess whether TAVI confers a survival benefit compared with medical therapy...
  51. doi Transcatheter aortic valve implantation in patients with very high risk for conventional aortic valve replacement
    Matthias Thielmann
    Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    Ann Thorac Surg 88:1468-74. 2009
    ....
  52. doi Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    JACC Cardiovasc Interv 3:1141-9. 2010
    ..The aim of this study was to determine the influence of baseline renal function and periprocedural acute kidney injury (AKI) on prognosis after transcatheter aortic valve implantation (TAVI)...
  53. doi Incidence and predictors of permanent pacemaker requirement after transcatheter aortic valve implantation with a self-expanding bioprosthesis
    Nuno Dias Ferreira
    Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal
    Pacing Clin Electrophysiol 33:1364-72. 2010
    ..Based on a single-center experience, we aim to assess the incidence of postprocedural conduction disorders, need for PPM, and its determinants after TAVI with a self-expanding bioprosthesis...
  54. doi Persistent conduction abnormalities and requirements for pacemaking six months after transcatheter aortic valve implantation
    Nicolo Piazza
    Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 6:475-84. 2010
    ..In this prospective study, we examined the incidence of post-procedural and 6-month conduction abnormalities and need for permanent pacemaking after TAVI...
  55. pmc Transapical aortic valve replacement under real-time magnetic resonance imaging guidance: experimental results with balloon-expandable and self-expanding stents
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Cardiothorac Surg 39:822-8. 2011
    ..Whether there are different advantages to SE or BE stents is unknown. We report rtMRI-guided tAVI in a porcine model using both SE and BE stents, and compare the differences between the stents...
  56. doi Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve
    Nicolo Piazza
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    JACC Cardiovasc Interv 1:310-6. 2008
    ..In this retrospective study, we examined the incidence of post-procedural conduction abnormalities and the need for pacing in patients undergoing percutaneous implantation of the aortic valve...
  57. doi Role of multislice computed tomography in transcatheter aortic valve replacement
    David A Wood
    Division of Cardiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 103:1295-301. 2009
    ..Neither eccentricity nor calcific deposits appeared to contribute significantly to severity of paravalvular regurgitation after TAVR...
  58. doi Technique of transcatheter aortic valve implantation with the Edwards-Sapien heart valve using the transfemoral approach
    Alain Cribier
    Department of Cardiology, Rouen University, Hospital Charles, Nicolle and INSERM 144, Rouen, France
    Herz 34:347-56. 2009
    ..At the present time, the indications should be restricted to nonoperable or surgical high-risk patients and the procedure performed by experienced and formally trained physicians working in an optimal multidisciplinary environment...
  59. doi Incidence and predictors of atrioventricular conduction impairment after transcatheter aortic valve implantation
    Laurent Roten
    Department of Cardiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
    Am J Cardiol 106:1473-80. 2010
    ....
  60. doi Reoperative mitral valve surgery by the port access minithoracotomy approach is safe and effective
    Steven R Meyer
    Division of Cardiovascular Surgery, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 87:1426-30. 2009
    ..The purpose of this study was to examine the results of port access MV surgery through right minithoracotomy in patients with previous cardiac surgery performed through median sternotomy...
  61. doi Postoperative permanent pacemaker implantation in patients undergoing trans-catheter aortic valve implantation: what is the incidence and are there any predicting factors?
    Matthew G D Bates
    Institute for Ageing and Health, Newcastle University, and Department of Cardiology, Freeman Hospital, Newcastle upon Tyne NE2 4HH, UK
    Interact Cardiovasc Thorac Surg 12:243-53. 2011
    ..All patients should be made aware of the high risk of PPM implantation with TAVI...
  62. doi Assessment of the aortic annulus by multislice computed tomography, contrast aortography, and trans-thoracic echocardiography in patients referred for transcatheter aortic valve implantation
    Apostolos Tzikas
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 77:868-75. 2011
    ....
  63. ncbi Vascular complications with transcatheter aortic valve implantation using the 18 Fr Medtronic CoreValve System: the Rotterdam experience
    Nicolas M Van Mieghem
    Department of Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands
    EuroIntervention 5:673-9. 2010
    ..Access site complications, therefore, can be a concern. The aim of this study is to present the 30-day incidence of major and minor vascular complications in patients treated with the third generation 18 Fr Medtronic CoreValve System...
  64. doi Guidelines for reporting mortality and morbidity after cardiac valve interventions
    Cary W Akins
    The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 85:1490-5. 2008
  65. doi Progress and current status of percutaneous aortic valve replacement: results of three device generations of the CoreValve Revalving system
    Eberhard Grube
    Departments of Cardiology, Cardiac Surgery, and Anaesthesiology, HELIOS Heart Center Siegburg, Ringstrasse 49, Siegburg, Germany
    Circ Cardiovasc Interv 1:167-75. 2008
    ..This study was intended to provide a summary of the development and current safety and efficacy status of the self-expanding CoreValve Revalving prosthesis...
  66. ncbi Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN prosthesis: incidence and impact on outcome
    Gregory Ducrocq
    Department of Cardiology, Bichat Claude Bernard Hospital, Paris, France
    EuroIntervention 5:666-72. 2010
    ..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...
  67. doi Results of transfemoral or transapical aortic valve implantation following a uniform assessment in high-risk patients with aortic stenosis
    Dominique Himbert
    Department of Cardiology, Assistance Publique Hopitaux de Paris, Bichat Claude Bernard Hospital, Paris, France
    J Am Coll Cardiol 54:303-11. 2009
    ..We sought to describe the results of a strategy offering either transfemoral or transapical aortic valve implantation in high-risk patients with severe aortic stenosis...
  68. doi Unexpected complications of transapical aortic valve implantation
    Nawwar Al-Attar
    Department of Cardiovascular Surgery, Bichat Claude Bernard Hospital, Paris, France
    Ann Thorac Surg 88:90-4. 2009
    ..However, specific problems of this new procedure are not well-described. Unexpected complications due to the procedure and their management are reported...
  69. ncbi Clinical profile and natural history of 453 nonsurgically managed patients with severe aortic stenosis
    Padmini Varadarajan
    Division of Cardiology, Loma Linda University Medical Center, Loma Linda, California, USA
    Ann Thorac Surg 82:2111-5. 2006
    ..However, aortic valve replacement (AVR) is not offered to many patients with severe AS for various reasons. We investigated the profile and survival patterns of patients with severe AS who did not have AVR...
  70. ncbi Magnetic resonance imaging to assess the hemodynamic effects of pulmonary valve replacement in adults late after repair of tetralogy of fallot
    Hubert W Vliegen
    Department of Cardiology, Leiden University Medical Center, The Netherlands H W Vliegen LUMC nl
    Circulation 106:1703-7. 2002
    ..In this study, MRI was used to assess the effect of PVR on RV function and PR. Clinical improvement was established by means of the NYHA classification...
  71. ncbi Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 30:15-9. 2006
    ..The aim of this study was to evaluate the impact of patient prosthesis mismatch (PPM) and additional risk factors on outcome after aortic valve replacement (AVR)...
  72. ncbi Treatment of destructive aortic valve endocarditis with the Freestyle Aortic Root Bioprosthesis
    Ludwig C Müller
    Department of Cardiac Surgery, University of Innsbruck, Innsbruck, Austria
    Ann Thorac Surg 75:453-6. 2003
    ..Homograft aortic roots are the conduits of choice, but because they are not available in all cases, alternative conduits are needed...
  73. ncbi Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II6-10. 1999
    ..The aim of this prospectively randomized study was to evaluate left ventricular hypertrophy and its regression after stentless versus conventional biological aortic valve replacement...
  74. doi Transapical minimally invasive aortic valve implantation; the initial 50 patients
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Eur J Cardiothorac Surg 33:983-8. 2008
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  75. doi Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin
    Todd K Rosengart
    State University of New York Stony Brook, USA
    Circulation 117:1750-67. 2008
    ....
  76. doi Transcatheter aortic valve implantation: impact on clinical and valve-related outcomes
    John G Webb
    St Paul s Hospital, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Circulation 119:3009-16. 2009
    ..Transcatheter aortic valve implantation is an alternative to open heart surgery in patients with aortic stenosis. However, long-term data on a programmatic approach to aortic valve implantation remain sparse...
  77. ncbi Malignant natural history of asymptomatic severe aortic stenosis: benefit of aortic valve replacement
    Ramdas G Pai
    Division of Cardiology, Loma Linda University Medical Center, Loma Linda, California, USA
    Ann Thorac Surg 82:2116-22. 2006
    ..However, symptoms are subjective and would depend upon patient's life style. We examined the natural and unnatural history of initially asymptomatic patients with severe AS...
  78. ncbi Percutaneous transcatheter aortic valve replacement: first transapical implant in Asia
    V T T Chao
    Department of Cardiothoracic Surgery, National Heart Centre, 17 Third Hospital Avenue, Singapore 168752
    Singapore Med J 51:69-72. 2010
    ..A 79-year-old Chinese woman with symptomatic severe AS and peripheral arterial disease, who was at high surgical risk, was successfully treated, and had good functional and haemodynamic results at the three-month follow-up...
  79. doi Implantation of two self-expanding aortic bioprosthetic valves during the same procedure-Insights into valve-in-valve implantation ("Russian doll concept")
    Nicolo Piazza
    Interventional Cardiology Department, Erasmus MC, Thoraxcenter, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 73:530-9. 2009
    ..We discuss also the potential valve of on-line quantitative angiography for assessing the depth of valve implantation and the need to implant a second valve...
  80. doi Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study
    Philipp Kahlert
    West German Heart Center Essen, Department of Cardiology, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Circulation 121:870-8. 2010
    ..The rate of clinically silent cerebral ischemia is unknown but may be even higher...
  81. doi Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 55:1427-32. 2010
    ..The aim of this study was prospective investigation of silent and clinically apparent cerebral embolic events and neurological impairment after transfemoral aortic valve implantation (TAVI)...
  82. doi New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
    ..Here we report implantation of this new valve in a patient. The valve demonstrated excellent function with a low transvalvular gradient...
  83. doi Transapical transcatheter aortic valve implantation: follow-up to 3 years
    Jian Ye
    Division of Cardiac Surgery, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 139:1107-13, 1113.e1. 2010
    ..We now report clinical and echocardiographic outcomes of transapical aortic valve implantation in 71 patients...
  84. doi Effect of altering pathologic right ventricular loading conditions by percutaneous pulmonary valve implantation on exercise capacity
    Philipp Lurz
    Cardiovascular Unit, UCL Institute of Child Health and Cardiorespiratory Unit, Great Ormond Street Hospital for Children, London, UK
    Am J Cardiol 105:721-6. 2010
    ..A reduction in the RVOT gradient, even small gradients, was the only independent predictor of improved peak oxygen uptake in both patient groups, irrespective of improved pulmonary valve competence...
  85. doi Electrocardiographic changes and clinical outcomes after transapical aortic valve implantation
    Marcos Gutierrez
    Quebec Heart and Lung Institute, Quebec, Quebec G1V 4G5, Canada
    Am Heart J 158:302-8. 2009
    ..The objective of our study was to determine the incidence, type, and timing of ECG changes associated with TAVI...
  86. doi Transcatheter aortic valve prosthesis surgically replaced 4 months after implantation
    Hans Gustav Thyregod
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Eur J Cardiothorac Surg 37:494-6. 2010
    ..We report the first case of surgical valve replacement in a patient with a dysfunctional transcatheter-implanted aortic valve prosthesis 4 months after implantation...
  87. doi Meta-analysis of pulmonary valve replacement after operative repair of tetralogy of fallot
    Eddie Wai yin Cheung
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People s Republic of China
    Am J Cardiol 106:552-7. 2010
    ..In conclusion, surgical PVR in patients after tetralogy of Fallot repair has been associated with low early and late mortality and significant decreases in RV volumes but no changes in the RV ejection fraction or QRS duration...
  88. doi An integrated pericardial valved stent special for percutaneous tricuspid implantation: an animal feasibility study
    Yuan Bai
    Department of Cardiology, Changhai Hospital, The Second Military Medical University, Shanghai, PR China
    J Surg Res 160:215-21. 2010
    ..To broaden the indications of percutaneous approach to atrioventricular valves replacement, we developed a novel valved stent and evaluated the feasibility and safety of percutaneous implantation of the device in the tricuspid position...
  89. ncbi Thirty-day outcome and vascular complications after transarterial aortic valve implantation using both Edwards Sapien and Medtronic CoreValve bioprostheses in a mixed population
    Didier Tchetche
    Clinique Pasteur, Toulouse, France
    EuroIntervention 5:659-65. 2010
    ..We report 30-day data from a mixed population of patients treated with either Medtronic CoreValve (MCV) or Edwards SAPIEN (ES) valves...
  90. doi Atrioventricular block after transcatheter balloon expandable aortic valve implantation
    Ajay Sinhal
    Heart Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    JACC Cardiovasc Interv 1:305-9. 2008
    ..Transcatheter aortic valve replacement (AVR) is a promising approach to aortic valve disease. The implications of this new therapy are not entirely known. We describe the potential for the development of new atrioventricular (AV) block...
  91. doi Quality of life assessment after percutaneous aortic valve implantation
    Gian Paolo Ussia
    Division of Cardiology, Ferrarotto Hospital, University of Catania, Via Citelli 6, Catania, Italy
    Eur Heart J 30:1790-6. 2009
    ..To assess the NYHA class and the quality of life (QoL) scores after percutaneous aortic valve implantation (PAVI) with the 18-Fr CoreValve prosthesis...
  92. doi Geometry and degree of apposition of the CoreValve ReValving system with multislice computed tomography after implantation in patients with aortic stenosis
    Carl J Schultz
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 54:911-8. 2009
    ..Using multislice computed tomography (MSCT), we sought to evaluate the geometry and apposition of the CoreValve ReValving System (CRS, Medtronic, Luxembourgh, Luxembourgh) in patients with aortic stenosis...
  93. doi Pulmonary valve replacement after tetralogy of Fallot repair in preadolescent patients
    C Wesley Lindsey
    Sibley Heart Center Cardiology, Department of Pediatrics, Division of Pediatric Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 89:147-51. 2010
    ..Most studies addressing the role of PVR have examined older adolescents or adults. Less is known about the potential benefits of PVR in preadolescents with TOF and significant right ventricular dilatation...
  94. doi Unexpected left ventricular free-wall rupture following an aortic catheter-valve implantation
    Enrico Ferrari
    Department of Cardio Vascular Surgery, University Hospital of Lausanne CHUV, Lausanne, Switzerland
    Eur J Cardiothorac Surg 37:242-4. 2010
    ..To the best of our knowledge, this is the first described case of a left ventricular free-wall rupture occurring after an otherwise non-complicated standard catheter-based aortic valve replacement...
  95. pmc The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is not appropriate for withholding surgery in high-risk patients with aortic stenosis: a retrospective cohort study
    Dimitri Kalavrouziotis
    Department of Surgery, Division of Cardiac Surgery, Queen Elizabeth II Health Sciences Centre, Dalhousie University, 1796 Summer Street, Room 2269, Halifax, Nova Scotia, B3H 3A7, Canada
    J Cardiothorac Surg 4:32. 2009
    ..The objective of this study was to determine the accuracy of the EuroSCORE in predicting mortality following aortic valve replacement (AVR)...
  96. doi Predictors for permanent pacemaker requirement after transcatheter aortic valve implantation with the CoreValve bioprosthesis
    Hasan Jilaihawi
    Glenfield Hospital, Leicester, United Kingdom
    Am Heart J 157:860-6. 2009
    ..We hypothesized that the need for PPM after CoreValve (Corevalve Inc, Irvine, CA) can be predicted with a combination of baseline variables...
  97. doi Frequency of conduction disturbances after transcatheter implantation of an Edwards Sapien aortic valve prosthesis
    Matthieu Godin
    Department of Cardiology, Rouen University Hospital and INSERM U, University of Rouen, France
    Am J Cardiol 106:707-12. 2010
    ..The physical properties of this prosthesis may explain this observation...
  98. doi Cerebrovascular events after stentless aortic valve replacement during a 9-year follow-up period
    Helmut Gulbins
    Department of Cardiac Surgery, Heart Institute Lahr, Institute of Cardiovascular Medicine, University Witten Herdecke, Hamburg, Germany
    Ann Thorac Surg 86:769-73. 2008
    ..The purpose of this study was to evaluate the incidence of cerebrovascular events during long-term follow-up after stentless aortic valve replacement...
  99. ncbi Effects of pulmonary valve replacement on QRS duration and right ventricular cavity size late after repair of right ventricular outflow tract obstruction
    Abdul R Doughan
    Adult Congenital Cardiac Program, Emory University Hospital School of Medicine, Atlanta, Georgia 30303, USA
    Am J Cardiol 95:1511-4. 2005
    ..93, p <0.0001) as well as after (r = 0.82, p <0.001) PVR. In patients with pulmonary regurgitation late after repair of RV outflow tract obstruction, PVR reduces maximal QRS duration with a concomitant decrease in RV volumes...
  100. ncbi Stentless versus conventional xenograft aortic valve replacement: midterm results of a prospectively randomized trial
    Sven Lehmann
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 84:467-72. 2007
    ..The purpose of this study was to analyze the 5- to 8-year clinical results after prospectively randomized stentless versus conventional aortic valve replacement...
  101. ncbi Aortic valve replacement in patients with impaired ventricular function
    Ram Sharony
    Division of Cardiothoracic Surgery, Department of Surgery, New York University School of Medicine, New York, New York, USA
    Ann Thorac Surg 75:1808-14. 2003
    ..Patients with reduced ventricular function undergoing aortic valve replacement have increased operative risks, but the impact of valvular pathophysiology and other risk factors has not been clearly defined...

Research Grants102 found, 100 shown here

  1. Quality Improvement and Outcomes for Strokes After CABG
    DONALD LIKOSKY; Fiscal Year: 2004
    ..abstract_text> ..
  2. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2010
    ....
  3. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2007
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  4. In Vivo IVUS Image-Based Modeling for Human Coronary Plaque Assessment
    DALIN contact TANG; Fiscal Year: 2011
    ..Commercialization of the research results is possible with the automation of model construction and data analysis procedures. ..
  5. STICH Trial-Coordinating Center
    Robert Jones; Fiscal Year: 2007
    ..abstract_text> ..
  6. Biventricular Pacing After Cardiopulmonary Bypass
    HENRY SPOTNITZ; Fiscal Year: 2009
    ..The protocol will provide new and important scientific information that will benefit not only surgical patients but also the general population of BiVP recipients. ..
  7. The Texas Medical Center Regional Coordinating Center for Heart Failure
    Douglas Mann; Fiscal Year: 2007
    ..Douglas Mann, who has experience with phase I - IV clinical trials, and who has close working relationship with of the investigators in the proposed TMC RCC by virtue of his 14 year tenure in the Texas Medical Center. (End of Abstract) ..
  8. Understanding mechanisms of Fontan failure and key predictors for patient outcome
    Ajit P Yoganathan; Fiscal Year: 2010
    ..Understanding these interconnections will provide the means to develop optimal medical strategies to improve those outcomes. ..
  9. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..abstract_text> ..
  10. CHRONIC ISCHEMIC MR-MECHANISMS & NOVEL SURGICAL THERAPY
    D Miller; Fiscal Year: 2004
    ..These experiments promise to add fundamental knowledge which will lead to more intelligent design of new, more effective, and more predictable surgical approaches for patients with CAD and chronic ischemic mitral regurgitation. ..
  11. Computational Modeling of Mechanical Heart Valves
    Ajit Yoganathan; Fiscal Year: 2006
    ..This work will also lead to a computational framework for assessing the likelihood that implantation of a given MPHV design may lead to thromboembolic complications. ..
  12. Biventricular Pacing After Cardiopulmonary Bypass
    HENRY SPOTNITZ; Fiscal Year: 2009
    ..The protocol will provide new and important scientific information that will benefit not only surgical patients but also the general population of BiVP recipients. ..
  13. Chronic Ischemic Mitral Regurgitation: Failure of a Mitral Control System?
    D Craig Miller; Fiscal Year: 2010
    ..This research is likely to lead to improved surgical treatments and medical therapies based on rational criteria, not only for chronic ischemic mitral regurgitation, but for other causes of mitral regurgitation, as well. ..
  14. VENTRICULAR DYNAMICS FROM SURGICALLY INSERTED MARKERS
    D Miller; Fiscal Year: 2007
    ..The knowledge gained should translate directly into more rational surgical as well as medical treatments for patients after an MI with CHF, CIMR, or both. ..
  15. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  16. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  17. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini M Rajamannan; Fiscal Year: 2010
    ..The objectives of this proposal are to determine if the Lrp5 receptor is critical in activation of mineralization in aortic valve calcification. ..
  18. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2010
    ..With our unique access to a large number of TAAD patients and expertise in cell and animal models, our project is feasible. ..
  19. Outcomes and Costs Associated with Frequency of Physician-Patient Visits on Hemod
    Areef Ishani; Fiscal Year: 2010
    ..Should the trial verify these findings, the current CMS policy should be revised, potentially leading to significant cost savings. ..
  20. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  21. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2009
    ..The objectives of this proposal are to determine if the Lrp5 receptor is critical in activation of mineralization in aortic valve calcification. ..
  22. Improving Neurologic Outcomes in Diabetics Undergoing Cardiac Surgery
    EDWARD HAL KINCAID; Fiscal Year: 2010
    ....
  23. In Vivo IVUS Image-Based Modeling for Human Coronary Plaque Assessment
    Jie Zheng; Fiscal Year: 2010
    ..Commercialization of the research results is possible with the automation of model construction and data analysis procedures. ..
  24. Stroke & cognition in surgical aortic stenosis
    Thomas Floyd; Fiscal Year: 2009
    ..Finally, the study database will allow us to closely examine the long-term risks for cognitive impairment & dementia from embolic processes during heart surgery.. ..
  25. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2009
    ..The objectives of this proposal are to determine if the Lrp5 receptor is critical in activation of mineralization in aortic valve calcification. ..
  26. Translational studies in Heart Failure Gene Therapy
    Charles Bridges; Fiscal Year: 2009
    ..Successful completion of this study may lead to alternatives to heart transplantation and permanent mechanical assist devices in the treatment of end stage heart failure. ..
  27. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2007
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  28. GENETICS AND GENOMICS OF HUMAN DISEASE
    Richard Lifton; Fiscal Year: 2007
    ..Support is requested for 10 graduate students per year for a five-year period. ..
  29. Matrix Metalloproteinases in Thoracic Aortic Dissection
    SCOTT LEMAIRE; Fiscal Year: 2007
    ....
  30. Cardiac Surgical Ischemia: Biophysical Aspects
    Irvin Krukenkamp; Fiscal Year: 2006
    ..abstract_text> ..
  31. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  32. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  33. Grape Seed Extract-Cardiac Impact and Drug Interaction
    Steven Bolling; Fiscal Year: 2005
    ..Considering the increasing use of this botanical extract, improved knowledge of safety and efficacy is imperative. ..
  34. Endocytosis in cardiac myocytes
    Ion Jovin; Fiscal Year: 2005
    ..The discoverry of polypeptides that guide macromolecules to specific cellular organelles or compartments can have profound implications for understanding microbial invasion and for refining gene therapy. ..
  35. Studies in pig-to-primate cardiac xenotransplantation
    CHRISTOPHER MC GREGOR; Fiscal Year: 2007
    ..In addition, by attempting to reverse rejection episodes with plasmapheresis we will identify the initiating mechanism of graft rejection. This proposal, if successful, lays the groundwork for the clinical application of cardiac XTx. ..
  36. Testing the Pediatric Cardiac Quality of Life Inventory
    Bradley Marino; Fiscal Year: 2007
    ..S. and the U.K. The proposed didactic and research experiences described will ensure that Dr. Marino becomes an independent physician scientist in the field of pediatric cardiovascular outcomes research. ..
  37. PATHOBIOLOGY OF CEREBRAL CAVERNOUS MALFORMATION
    Richard Lifton; Fiscal Year: 2002
    ..They have established a collection of these lesions and have begun developing cell cultures of different cell lines from lesions in order to pursue this aim. ..
  38. Long-term White Matter Changes Resulting from Delirium after Surgery
    James Rudolph; Fiscal Year: 2007
    ..If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. ..
  39. Stroke & cognition in surgical aortic stenosis
    Thomas Floyd; Fiscal Year: 2007
    ..Finally, the study database will allow us to closely examine the long-term risks for cognitive impairment & dementia from embolic processes during heart surgery.. ..
  40. The long-term consequences of postoperative acute kidney injury
    Areef Ishani; Fiscal Year: 2007
    ..Once the AKI- associated burden of CKD has been precisely estimated and modifiable factors have been identified, clinical trials can be performed that may reduce this disease burden. ..
  41. Cardiothoracic Surgical Network Clinical Center
    Peter Smith; Fiscal Year: 2007
    ..The successful achievement of these aims will be a significant contribution to the Cardiac Surgery Network and the overall care of patients with surgical cardiovascular disease. (End of Abstract) ..
  42. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2007
    ..Finally, we will apply them prospectively to predict graft patency and wound healing after amputation. ..