heart valve prosthesis implantation

Summary

Summary: Surgical insertion of synthetic material to repair injured or diseased heart valves.

Top Publications

  1. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  2. ncbi Transcatheter versus surgical aortic-valve replacement in high-risk patients
    Craig R Smith
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 364:2187-98. 2011
  3. ncbi Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery
    Martin B Leon
    Columbia University Medical Center NewYork Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 363:1597-607. 2010
  4. ncbi Two-year outcomes after transcatheter or surgical aortic-valve replacement
    Susheel K Kodali
    Columbia University Medical Center and New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 366:1686-95. 2012
  5. ncbi Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry
    Neil E Moat
    Royal Brompton and Harefield National Health Service NHS Foundation Trust, London, United Kingdom
    J Am Coll Cardiol 58:2130-8. 2011
  6. doi 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to
    Robert O Bonow
    Circulation 118:e523-661. 2008
  7. ncbi Registry of transcatheter aortic-valve implantation in high-risk patients
    Martine Gilard
    Centre Hospitalier Universitaire CHU Brest, Brest, France
    N Engl J Med 366:1705-15. 2012
  8. pmc Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
    Eur Heart J 32:205-17. 2011
  9. ncbi Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    Circulation 106:3006-8. 2002
  10. ncbi Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis
    Corrado Tamburino
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Circulation 123:299-308. 2011

Detail Information

Publications317 found, 100 shown here

  1. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  2. ncbi Transcatheter versus surgical aortic-valve replacement in high-risk patients
    Craig R Smith
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 364:2187-98. 2011
    ..However, the two procedures have not been compared in a randomized trial involving high-risk patients who are still candidates for surgical replacement...
  3. ncbi Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery
    Martin B Leon
    Columbia University Medical Center NewYork Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 363:1597-607. 2010
    ..Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment for high-risk patients with aortic stenosis...
  4. ncbi Two-year outcomes after transcatheter or surgical aortic-valve replacement
    Susheel K Kodali
    Columbia University Medical Center and New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 366:1686-95. 2012
    ..However, longer-term follow-up is necessary to determine whether TAVR has prolonged benefits...
  5. ncbi Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry
    Neil E Moat
    Royal Brompton and Harefield National Health Service NHS Foundation Trust, London, United Kingdom
    J Am Coll Cardiol 58:2130-8. 2011
    ....
  6. doi 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to
    Robert O Bonow
    Circulation 118:e523-661. 2008
  7. ncbi Registry of transcatheter aortic-valve implantation in high-risk patients
    Martine Gilard
    Centre Hospitalier Universitaire CHU Brest, Brest, France
    N Engl J Med 366:1705-15. 2012
    ..We report the results of a prospective multicenter study of the French national transcatheter aortic-valve implantation registry, FRANCE 2...
  8. pmc Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
    Eur Heart J 32:205-17. 2011
    ..To make these consensus definitions accessible to all stakeholders in TAVI clinical research through a peer reviewed publication, on behalf of the public health...
  9. ncbi Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    Circulation 106:3006-8. 2002
    ..Valve replacement had been declined for this patient, and balloon valvuloplasty had been performed with nonsustained results...
  10. ncbi Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis
    Corrado Tamburino
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Circulation 123:299-308. 2011
    ....
  11. ncbi Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 55:1080-90. 2010
    ....
  12. ncbi Transcatheter aortic valve implantation: lessons from the learning curve of the first 270 high-risk patients
    Ronen Gurvitch
    Department of Cardiology and Cardiothoracic Surgery, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Catheter Cardiovasc Interv 78:977-84. 2011
    ..Transcatheter aortic valve implantation (TAVI) is a rapidly evolving strategy for therapy of aortic stenosis. We describe the effect of the learning curve from the first 270 high-risk patients in Vancouver, Canada...
  13. ncbi One-year outcomes of cohort 1 in the Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) registry: the European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    Director of Cardiovascular Services, Cardiology Department, St Thomas Hospital, Westminster Bridge Rd, London, UK
    Circulation 124:425-33. 2011
    ..Transcatheter aortic valve implantation was developed to provide a therapeutic option for patients considered to be ineligible for, and to mitigate mortality and morbidity associated with, high-risk surgical aortic valve replacement...
  14. ncbi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
    ..The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008...
  15. ncbi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
    ..Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known...
  16. ncbi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry...
  17. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported...
  18. ncbi Percutaneous repair or surgery for mitral regurgitation
    Ted Feldman
    Evanston Hospital, NorthShore University Health System, Evanston, IL 60201, USA
    N Engl J Med 364:1395-406. 2011
    ..Mitral-valve repair can be accomplished with an investigational procedure that involves the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet...
  19. ncbi Dual antiplatelet therapy versus aspirin alone in patients undergoing transcatheter aortic valve implantation
    Gian Paolo Ussia
    Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy
    Am J Cardiol 108:1772-6. 2011
    ..71) and 6 months (18% vs 15%; p = 0.85). In conclusion, the strategy of adding clopidogrel to aspirin for 3 months after TAVI was not found to be superior to aspirin alone. These results must be confirmed in a larger randomized trial...
  20. ncbi Risk of stroke after transcatheter aortic valve implantation (TAVI): a meta-analysis of 10,037 published patients
    Holger Eggebrecht
    Cardioangiological Center Bethanien CCB, Frankfurt, Germany
    EuroIntervention 8:129-38. 2012
    ..We aimed to review all currently published literature and estimate the incidence of periprocedural stroke and outcomes in patients undergoing TAVI...
  21. ncbi Transcatheter aortic valve implantation: 3-year outcomes of self-expanding CoreValve prosthesis
    Gian Paolo Ussia
    Interventional Structural and Congenital Heart Disease Programme, Invasive Cardiology Division of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy
    Eur Heart J 33:969-76. 2012
    ..We sought to assess 3-year clinical and echocardiographic outcomes of patients undergoing TAVI with the third generation CoreValve prosthesis (Medtronic Incorporation, MN, USA)...
  22. ncbi Transapical aortic valve implantation: analysis of risk factors and learning experience in 299 patients
    Jörg Kempfert
    Department of Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Circulation 124:S124-9. 2011
    ..Transapical aortic valve implantation has evolved to a reproducible therapeutic option for high-risk patients. The aim of the present study was to evaluate our learning experience over 4 years and to analyze outcome-related risk factors...
  23. ncbi Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry
    Helene Eltchaninoff
    Cardiology Department, Charles Nicolle Hospital, University of Rouen INSERM U644, 1 rue de Germont, Rouen Cedex, France
    Eur Heart J 32:191-7. 2011
    ....
  24. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    ....
  25. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  26. ncbi Multimodal assessment of the aortic annulus diameter: implications for transcatheter aortic valve implantation
    David Messika-Zeitoun
    INSERM, U698, University Paris 7, Paris, France
    J Am Coll Cardiol 55:186-94. 2010
    ....
  27. ncbi Comparison of two-dimensional and three-dimensional imaging techniques for measurement of aortic annulus diameters before transcatheter aortic valve implantation
    Ertunc Altiok
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Heart 97:1578-84. 2011
    ..This study sought to compare different 2D and 3D imaging techniques and determine the accuracy of 3D transoesophageal echocardiography (TEE) for accurate analysis of aortic annulus dimensions...
  28. ncbi Beyond the short-term: clinical outcome and valve performance 2 years after transcatheter aortic valve implantation in 227 patients
    Sabine Bleiziffer
    Clinic for Cardiovascular Surgery, German Heart Center Munich, Germany
    J Thorac Cardiovasc Surg 143:310-7. 2012
    ..We report on 2-year follow-up clinical and echocardiographic results after transcatheter aortic valve implantation in 227 patients...
  29. ncbi Prognostic effect of inappropriately high left ventricular mass in asymptomatic severe aortic stenosis
    Giovanni Cioffi
    Department of Cardiology, Villa Bianca Hospital, Trento, Italy
    Heart 97:301-7. 2011
    ..The prognostic impact of iLVM was determined in 218 patients with asymptomatic severe AS...
  30. ncbi Assessment of the aortic annulus by multislice computed tomography, contrast aortography, and trans-thoracic echocardiography in patients referred for transcatheter aortic valve implantation
    Apostolos Tzikas
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 77:868-75. 2011
    ....
  31. ncbi Trans-apical aortic valve implantation using a new self-expandable bioprosthesis: initial outcomes
    Jörg Kempfert
    Heartcenter University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 40:1114-9. 2011
    ..As an alternative device, a self-expanding sub-coronary trans-apical bioprosthesis was evaluated...
  32. ncbi Cerebral embolism following transcatheter aortic valve implantation: comparison of transfemoral and transapical approaches
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 57:18-28. 2011
    ....
  33. ncbi Improvements in transcatheter aortic valve implantation outcomes in lower surgical risk patients: a glimpse into the future
    Ruediger Lange
    German Heart Center, Lazarette Strasse 36, Munich, Germany
    J Am Coll Cardiol 59:280-7. 2012
    ..The purpose of this study was to investigate the evolution of patient selection criteria for transcatheter aortic valve implantation (TAVI) and its impact on clinical outcomes...
  34. ncbi Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies
    Prateek J Khatri
    University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Ann Intern Med 158:35-46. 2013
    ....
  35. ncbi The German Aortic Valve Registry (GARY): a nationwide registry for patients undergoing invasive therapy for severe aortic valve stenosis
    A Beckmann
    Deutsche Gesellschaft für Thorax, Herz und Gefäßchirurgie DGTHG, Langenbeck Virchow Haus Luisenstrasse 58 59, Berlin, Germany
    Thorac Cardiovasc Surg 60:319-25. 2012
    ..In contrast to randomized controlled trials, GARY is a prospective, controlled, 5-year observational multicenter registry, and a real world investigation with only one exclusion criterion, the absence of patients' written consent...
  36. ncbi Standardized endpoint definitions for Transcatheter Aortic Valve Implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, New York, New York 10032, USA
    J Am Coll Cardiol 57:253-69. 2011
    ..To make these consensus definitions accessible to all stakeholders in TAVI clinical research through a peer reviewed publication, on behalf of the public health...
  37. ncbi Early experience with percutaneous transcatheter implantation of heart valve prosthesis for the treatment of end-stage inoperable patients with calcific aortic stenosis
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    J Am Coll Cardiol 43:698-703. 2004
    ..This study was done to assess the results of percutaneous heart valve (PHV) implantation in non-surgical patients with end-stage calcific aortic stenosis...
  38. ncbi Procedural, 30-day and one year outcome following CoreValve or Edwards transcatheter aortic valve implantation: results of the Belgian national registry
    Johan M Bosmans
    Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Antwerp, Belgium
    Interact Cardiovasc Thorac Surg 12:762-7. 2011
    ..This mid-term mortality was mainly related to age-related, non-cardiac complications...
  39. ncbi Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (VARC-2)
    Arie Pieter Kappetein
    Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands
    Eur J Cardiothorac Surg 42:S45-60. 2012
    ..In addition, this document is intended to expand the understanding of patient risk stratification and case selection...
  40. ncbi Magnetic resonance imaging evaluation of cerebral embolization during percutaneous aortic valve implantation: comparison of transfemoral and trans-apical approaches using Edwards Sapiens valve
    Parla Astarci
    Cardiovascular and Thoracic Surgery Department University Hospital Saint Luc, Brussels, Belgium
    Eur J Cardiothorac Surg 40:475-9. 2011
    ..Therefore, we compared the rate of cerebral embolisms with diffusion-weighted magnetic resonance imaging (DWI) in transfemoral (TF) and trans-apical (TA) approaches...
  41. ncbi Transcranial Doppler sound detection of cerebral microembolism during transapical aortic valve implantation
    T Drews
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Thorac Cardiovasc Surg 59:237-42. 2011
    ..However, whether it usually occurs, how often, and its clinical relevance are not known. We report the results of ultrasound microembolic signal detection in the middle cerebral artery during the procedure...
  42. ncbi Transcatheter aortic valve implantation for severe aortic stenosis-a new paradigm for multidisciplinary intervention: a prospective cohort study
    Rafal Dworakowski
    The Cardiac Unit of King s Health Partners, Denmark Hill, London, United Kingdom
    Am Heart J 160:237-43. 2010
    ..The aim of this study was to assess the feasibility of TAVI in elderly patients, the delivery of this technology with a multidisciplinary approach, and the use of traditional surgical scoring systems...
  43. ncbi Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percu
    Alec Vahanian
    Hopital Bichat, Paris, France
    Eur Heart J 29:1463-70. 2008
    ..To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development...
  44. ncbi Transcatheter aortic valve implantation for high-risk patients with severe aortic stenosis: A systematic review
    Tristan D Yan
    Department of Cardiothoracic Surgery, The University of Sydney, Royal Prince Alfred Hospital, Sydney 2050, Australia
    J Thorac Cardiovasc Surg 139:1519-28. 2010
    ..The present systematic review objectively assessed the safety and clinical effectiveness of transcatheter aortic valve implantation for patients at high surgical risk with severe aortic stenosis...
  45. ncbi Aortic annulus evaluation in transcatheter aortic valve implantation
    Andrea Hutter
    Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
    Catheter Cardiovasc Interv 76:1009-19. 2010
    ..We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI)...
  46. pmc Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement
    Rodrigo Bagur
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada G1V 4G5
    Eur Heart J 31:865-74. 2010
    ..surgical aortic valve replacement (SAVR) in patients with pre-procedural chronic kidney disease (CKD)...
  47. ncbi Percutaneous transarterial aortic valve implantation: what do we know?
    John Webb
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Heart J 32:140-7. 2011
    ..Nevertheless considerable work needs to be done before the indications for TAVI are expanded into lower risk groups. We review what is currently known about percutaneous transarterial implantation of the aortic valve...
  48. ncbi Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative)
    M Z Khawaja
    UK CoreValve Collaborative, Sussex Cardiac Centre, Brighton and Sussex University Hospital Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, UK
    Circulation 123:951-60. 2011
    ..We assessed the UK incidence of permanent pacing within 30 days of CoreValve implantation and formulated an anatomic and electrophysiological model...
  49. ncbi Prosthesis-patient mismatch: an update
    Jean G Dumesnil
    Quebec Heart and Lung Institute, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada G1V 4G5
    Curr Cardiol Rep 13:250-7. 2011
    ..Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation...
  50. ncbi Comparison between Society of Thoracic Surgeons score and logistic EuroSCORE for predicting mortality in patients referred for transcatheter aortic valve implantation
    Itsik Ben-Dor
    Interventional Cardiology, Washington Hospital Center, Washington, DC 20010, USA
    Cardiovasc Revasc Med 12:345-9. 2011
    ..We aimed to examine the correlation between STS and logistic EuroSCOREs and their performance characteristics in patients referred for TAVI...
  51. ncbi Transapical versus transfemoral aortic valve implantation: a comparison of survival and safety
    Malin Johansson
    Department of Cardiothoracic Surgery, Cardiothoracic Anesthesia and Intensive Care, Skåne University Hospital and Lund University, Lund, Sweden
    Ann Thorac Surg 91:57-63. 2011
    ..We aimed to evaluate access-related complications between the transfemoral (TF) and the transapical (TA) approach and to compare survival between TAVI and conventional AVR in propensity-score-matched patients...
  52. ncbi Multivariable prediction of in-hospital mortality associated with aortic and mitral valve surgery in Northern New England
    Edward R Nowicki
    Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Ann Thorac Surg 77:1966-77. 2004
    ..Development of reliable prediction rules requires large data sets with appropriate risk factors that are available before surgery...
  53. ncbi Patient-prosthesis mismatch does not affect survival following aortic valve replacement
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Cardiothorac Surg 30:10-4. 2006
    ..We analysed the effect of PPM at values predicting severe mismatch on survival following AVR in our unit...
  54. ncbi The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2--isolated valve surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Ann Thorac Surg 88:S23-42. 2009
    ..Expanding upon existing valve models, the new STS models include several nonfatal complications in addition to mortality...
  55. pmc One year follow-up of the multi-centre European PARTNER transcatheter heart valve study
    Thierry Lefevre
    Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy, France
    Eur Heart J 32:148-57. 2011
    ..Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option in high-risk patients with severe aortic stenosis...
  56. ncbi Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve function
    Victoria Delgado
    Department of Cardiology and Cardiothoracic Surgery, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    Eur Heart J 31:1114-23. 2010
    ..However, the underlying mechanisms of this complication remain unclear. The present evaluation studied the anatomic and morphological features of the aortic valve annulus that may predict aortic regurgitation after TAVI...
  57. ncbi Emboli capture using the Embol-X intraaortic filter in cardiac surgery: a multicentered randomized trial of 1,289 patients
    Michael K Banbury
    The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 76:508-15; discussion 515. 2003
    ..Particulate emboli are thought to play a significant role in the development of cardiac surgical complications. Intraaortic filtration of particulate emboli may reduce the burden of this morbidity in cardiac patients...
  58. ncbi Dilation of the pulmonary autograft after the Ross procedure
    T E David
    Divisions of Cardiovascular Surgery and Cardiology of Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 119:210-20. 2000
    ..Dilation of pulmonary autograft after the Ross procedure is being recognized with increasing frequency. This study was undertaken to examine the extent of this problem and factors that may be associated with it...
  59. ncbi Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography
    Arnold C T Ng
    Department of Cardiology, The Department of Cardiothoracic Surgery, and the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Circ Cardiovasc Imaging 3:94-102. 2010
    ..We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI)...
  60. ncbi Aortic valve replacement in octogenarians: utility of risk stratification with EuroSCORE
    Sergey Leontyev
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 87:1440-5. 2009
    ..We evaluated characteristics and outcomes of elderly patients undergoing isolated AVR with a particular focus on the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk stratification...
  61. ncbi Noninvasive evaluation of the aortic root with multislice computed tomography implications for transcatheter aortic valve replacement
    Laurens F Tops
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    JACC Cardiovasc Imaging 1:321-30. 2008
    ..In the present study, the anatomy of the aortic root was assessed noninvasively with multislice computed tomography (MSCT)...
  62. ncbi Biventricular response after pulmonary valve replacement for right ventricular outflow tract dysfunction: is age a predictor of outcome?
    Alessandra Frigiola
    Cardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Circulation 118:S182-90. 2008
    ..We wanted to assess the determinants of improvement after PVR for pulmonary regurgitation over a wide range of patient ages and to use any identified predictors to compare clinical outcomes between patient groups...
  63. ncbi Observed and relative survival after aortic valve replacement
    P Kvidal
    Department of Cardiology, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 35:747-56. 2000
    ..We sought to evaluate the effects of a number of factors that can potentially determine the optimal time for aortic valve replacement (AVR) and the observed and relative survival after the operation...
  64. ncbi Role of multislice computed tomography in transcatheter aortic valve replacement
    David A Wood
    Division of Cardiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 103:1295-301. 2009
    ..Neither eccentricity nor calcific deposits appeared to contribute significantly to severity of paravalvular regurgitation after TAVR...
  65. pmc To operate or not on elderly patients with aortic stenosis: the decision and its consequences
    B J Bouma
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, PO Box 2700, 1100 DE Amsterdam, The Netherlands
    Heart 82:143-8. 1999
    ..To evaluate the application of guidelines in the decision making process leading to medical or surgical treatment for aortic stenosis in elderly patients...
  66. ncbi Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study
    Philipp Kahlert
    West German Heart Center Essen, Department of Cardiology, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Circulation 121:870-8. 2010
    ..The rate of clinically silent cerebral ischemia is unknown but may be even higher...
  67. ncbi Survival after transapical and transfemoral aortic valve implantation: talking about two different patient populations
    Sabine Bleiziffer
    Clinic for Cardiovascular Surgery, German Heart Center Munich, Lazarettstrasse 36, Munich, Germany
    J Thorac Cardiovasc Surg 138:1073-80. 2009
    ..We analyzed survival in patients undergoing transcatheter aortic valve implantation with special emphasis on the access site for implantation...
  68. ncbi Role of echocardiography in percutaneous aortic valve implantation
    Robert R Moss
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    JACC Cardiovasc Imaging 1:15-24. 2008
    ..This study was designed to investigate the usefulness and limitations of echocardiography in optimizing the outcome of percutaneous aortic valve implantation...
  69. ncbi Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
    ..Transapical aortic valve implantation is a new minimally invasive technique for beating heart, off-pump, aortic valve implantation in high-risk patients...
  70. ncbi Alpha-Gal on bioprostheses: xenograft immune response in cardiac surgery
    K Z Konakci
    Medizinische Universität Wien, Vienna, Austria
    Eur J Clin Invest 35:17-23. 2005
    ..We sought to investigate whether a specific alpha-Gal immune response may play a role in this clinical scenario...
  71. ncbi Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair
    A L Knauth
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart 94:211-6. 2008
    ..Factors associated with impaired clinical status in a cross-sectional study of patients with repaired tetralogy of Fallot (TOF) have been reported previously...
  72. ncbi First-in-man implantation of a novel percutaneous valve: a new approach to medical device development
    Silvia Schievano
    Cardiovascular Unit, UCL Institute of Child Health, London, United Kingdom
    EuroIntervention 5:745-50. 2010
    ..To present our experience of 'first-in-man' implantation of a new percutaneous pulmonary valve into a dilated pulmonary trunk, using patient specific data to influence the design of the device and ensure patient safety...
  73. ncbi Aortic valve replacement with 17-mm mechanical prostheses: is patient-prosthesis mismatch a relevant phenomenon?
    Andrea Garatti
    I Division of Cardiac Surgery, IRCCS Policlinico San Donato Hospital, San Donato Milanese, Milan, Italy
    Ann Thorac Surg 91:71-7. 2011
    ..We sought to evaluate the long-term performance of a consecutive cohort of patients implanted with a 17-mm bileaflet mechanical prosthesis...
  74. ncbi Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis
    Ana V Villar
    Department of Physiology and Pharmacology, University of Cantabria School of Medicine, Spain
    Heart 97:1132-7. 2011
    ....
  75. ncbi Crimping may affect the durability of transcatheter valves: an experimental analysis
    Philipp Kiefer
    Department of Cardiac Surgery, Heart Center, Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 92:155-60. 2011
    ..Transcatheter aortic valve implantation has gained widespread acceptance to treat elderly high-risk patients with aortic stenosis. We used a subcutaneous rat model to evaluate whether crimping may affect valve long-term durability...
  76. ncbi Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status
    Timothy A Fairbairn
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Heart 98:18-23. 2012
    ..Silent' cerebral infarction and stroke are complications of transcatheter aortic valve implantation (TAVI)...
  77. ncbi Effect of prosthesis-patient mismatch on long-term survival with aortic valve replacement: assessment to 15 years
    W R Eric Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    Ann Thorac Surg 89:51-8; discussion 59. 2010
    ..This study was performed to determine the predictors of mortality after aortic valve replacement and influence of prosthesis-patient mismatch on survival...
  78. ncbi Transfemoral aortic valve implantation new criteria to predict vascular complications
    Kentaro Hayashida
    Institut Cardiovasculaire Paris Sud, Massy, France
    JACC Cardiovasc Interv 4:851-8. 2011
    ..This study sought to evaluate the incidence, impact, and predictors of vascular complications in transcatheter aortic valve implantation (TAVI)...
  79. ncbi Acute left ventricle diastolic function improvement after transcatheter aortic valve implantation
    Alexandra Gonçalves
    Cardiovascular Institute, Unit of Methodology of the Investigation and Clinical Epidemiology, Preventive Medicine Department, Hospital Clinico San Carlos, Plaza de Cristo Rey, Madrid 28040, Spain
    Eur J Echocardiogr 12:790-7. 2011
    ..This study aimed to determine the acute haemodynamic effects of transcatheter aortic valve implantation (TAVI) in left ventricle (LV) diastolic performance, immediately after aortic valvuloplasty and prosthesis deployment...
  80. ncbi Transcatheter aortic valve implantation: current and future approaches
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, 2725 Chemin Ste Foy, G1V 4G5 Quebec City, QC, Canada
    Nat Rev Cardiol 9:15-29. 2012
    ....
  81. ncbi Transapical aortic valve implantation: incidence and predictors of paravalvular leakage and transvalvular regurgitation in a series of 358 patients
    Axel Unbehaun
    Deutsches Herzzentrum Berlin, Augustenburger Platz 1, Berlin, Germany
    J Am Coll Cardiol 59:211-21. 2012
    ..The aim of this study was to evaluate the results when the surgical concept of not accepting intraprocedural paravalvular leakage was applied for transcatheter aortic valve implantation (TAVI)...
  82. pmc The risk-to-benefit ratio of transcatheter aortic valve implantation in specific patient cohorts: a single-centre experience
    Miriam Puls
    Department of Cardiology and Pneumology, Georg August University of Goettingen, Gottingen, Germany
    Clin Res Cardiol 101:553-63. 2012
    ..However, information on the identification of patients gaining most benefit from this procedure is still limited. The aim of this study was to evaluate safety and efficacy of TAVI in different patient cohorts...
  83. ncbi Health-related quality of life after transcatheter or surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results from the PARTNER (Placement of AoRTic TraNscathetER Valve) Trial (Cohort A)
    Matthew R Reynolds
    Harvard Clinical Research Institute, Boston VA Healthcare System, Boston, Massachusetts, USA
    J Am Coll Cardiol 60:548-58. 2012
    ....
  84. ncbi Patient-prosthesis mismatch in patients with aortic stenosis undergoing isolated aortic valve replacement does not affect survival
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Ann Thorac Surg 89:60-4. 2010
    ..Data suggest that patient-prosthesis mismatch (PPM) adversely effects late survival after aortic valve replacement (AVR). This study examined the incidence and implications of PPM in patients undergoing isolated AVR...
  85. ncbi Clinical profile and natural history of 453 nonsurgically managed patients with severe aortic stenosis
    Padmini Varadarajan
    Division of Cardiology, Loma Linda University Medical Center, Loma Linda, California, USA
    Ann Thorac Surg 82:2111-5. 2006
    ..However, aortic valve replacement (AVR) is not offered to many patients with severe AS for various reasons. We investigated the profile and survival patterns of patients with severe AS who did not have AVR...
  86. ncbi Transcatheter aortic valve implantation through the ascending aorta: an alternative option for no-access patients
    Robert Bauernschmitt
    Clinic of Cardiovascular Surgery, The Technical University, Munich, Germany
    Heart Surg Forum 12:E63-4. 2009
    ..The ascending aorta approach might help to expand the implantation possibilities for those patients for whom the typical access sites are not available...
  87. ncbi Persistent conduction abnormalities and requirements for pacemaking six months after transcatheter aortic valve implantation
    Nicolo Piazza
    Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 6:475-84. 2010
    ..In this prospective study, we examined the incidence of post-procedural and 6-month conduction abnormalities and need for permanent pacemaking after TAVI...
  88. ncbi Transcatheter aortic valve implantation: evidence on safety and efficacy compared with medical therapy. A systematic review of current literature
    L Figulla
    Department of Cardiology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Clin Res Cardiol 100:265-76. 2011
    ..In this work, the methodology was applied to provide objective evidence on the efficacy and safety of TAVI at 1-year follow-up and to assess whether TAVI confers a survival benefit compared with medical therapy...
  89. ncbi Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation
    Jan Malte Sinning
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    JACC Cardiovasc Interv 3:1141-9. 2010
    ..The aim of this study was to determine the influence of baseline renal function and periprocedural acute kidney injury (AKI) on prognosis after transcatheter aortic valve implantation (TAVI)...
  90. ncbi Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percu
    Alec Vahanian
    Hopital Bichat, Paris, France
    Eur J Cardiothorac Surg 34:1-8. 2008
    ..To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development...
  91. ncbi Left thoracotomy for aortic and mitral valve surgery in a case of mediastinal displacement due to pneumonectomy
    Theodoro Barreda
    Departement de Chirurgie Cardiovasculaire, Institut de Cardiologie, Hopital Pitie Salpetriere, Paris, France
    J Heart Valve Dis 17:239-42. 2008
    ..Three weeks later, the patient had recovered a normal hemodynamic and spontaneous breathing. A left thoracotomy should be considered as an alternative approach for valve surgery in case of severe heart displacement...
  92. pmc Transapical aortic valve replacement under real-time magnetic resonance imaging guidance: experimental results with balloon-expandable and self-expanding stents
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Cardiothorac Surg 39:822-8. 2011
    ..Whether there are different advantages to SE or BE stents is unknown. We report rtMRI-guided tAVI in a porcine model using both SE and BE stents, and compare the differences between the stents...
  93. ncbi EuroSCORE overestimates the risk of cardiac surgery: results from the national registry of the German Society of Thoracic and Cardiovascular Surgery
    J F Gummert
    Direktor der Klinik für Thorax und Kardiovaskularchirurgie, Herz und Diabeteszentrum Nordrhein Westfalen, Universitätsklinik der Ruhruniversität Bochum, Bad Oeynhausen, Germany
    Clin Res Cardiol 98:363-9. 2009
    ..Several studies with relatively small patient numbers showed a substantial overestimation of risk by the EuroSCORE. The aim of our study was to evaluate whether the nationwide data support this finding...
  94. ncbi The acute hemodynamic effects of MitraClip therapy
    Robert J Siegel
    Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 1804, USA
    J Am Coll Cardiol 57:1658-65. 2011
    ..The objective of this study was to evaluate the acute hemodynamic consequences of mitral valve (MV) repair with the MitraClip device (Abbott Vascular, Menlo Park, California)...
  95. ncbi Transcatheter aortic valve implantation in patients with very high risk for conventional aortic valve replacement
    Matthias Thielmann
    Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    Ann Thorac Surg 88:1468-74. 2009
    ....
  96. ncbi Chronic ischaemic mitral regurgitation. Current treatment results and new mechanism-based surgical approaches
    Wobbe Bouma
    Department of Cardiothoracic Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Cardiothorac Surg 37:170-85. 2010
    ..Although promising, at this point these new procedures still lack investigation in large patient cohorts with long-term follow-up. They will, however, be the subject of much anticipated and necessary ongoing and future research...
  97. ncbi Risk scores for predicting outcomes in valvular heart disease: how useful?
    Michael J Mack
    Baylor Health Care System, The Heart Hospital Baylor Plano, TX 75093, USA
    Curr Cardiol Rep 13:107-12. 2011
    ..Ultimately, a new risk algorithm specific for TAVI will need to be developed once sufficient databases are developed...
  98. ncbi Incidence and predictors of permanent pacemaker requirement after transcatheter aortic valve implantation with a self-expanding bioprosthesis
    Nuno Dias Ferreira
    Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia Espinho, Vila Nova de Gaia, Portugal
    Pacing Clin Electrophysiol 33:1364-72. 2010
    ..Based on a single-center experience, we aim to assess the incidence of postprocedural conduction disorders, need for PPM, and its determinants after TAVI with a self-expanding bioprosthesis...
  99. ncbi Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve
    Nicolo Piazza
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    JACC Cardiovasc Interv 1:310-6. 2008
    ..In this retrospective study, we examined the incidence of post-procedural conduction abnormalities and the need for pacing in patients undergoing percutaneous implantation of the aortic valve...
  100. ncbi Technique of transcatheter aortic valve implantation with the Edwards-Sapien heart valve using the transfemoral approach
    Alain Cribier
    Department of Cardiology, Rouen University, Hospital Charles, Nicolle and INSERM 144, Rouen, France
    Herz 34:347-56. 2009
    ..At the present time, the indications should be restricted to nonoperable or surgical high-risk patients and the procedure performed by experienced and formally trained physicians working in an optimal multidisciplinary environment...
  101. ncbi Incidence and predictors of atrioventricular conduction impairment after transcatheter aortic valve implantation
    Laurent Roten
    Department of Cardiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
    Am J Cardiol 106:1473-80. 2010
    ....

Research Grants21

  1. Quality Improvement and Outcomes for Strokes After CABG
    DONALD LIKOSKY; Fiscal Year: 2004
    ..abstract_text> ..
  2. OPIOID HIBERNATION FACTORS FOR MYOCARDIAL PROTECTION
    Steven Bolling; Fiscal Year: 2002
    ..The ability of the delta opioids to effect myocardial protection suggests that the use of these molecules may be valuable in many clinical scenarios resulting in ischemia. ..
  3. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2008
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  4. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..abstract_text> ..
  5. Osteoblastogenesis in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2006
    ..If hypercholesterolemia stimulates the development of calcification in the aortic valve then the use of medical therapy such as HMG CoA reductase medications may have a role in the medical therapy of calcific aortic stenosis. ..
  6. Annular and Sub-Valvular Repair Techniques for Ischemic Mitral Regurgitation: In-
    Ajit P Yoganathan; Fiscal Year: 2010
    ..abstract_text> ..
  7. VENTRICULAR FUNCTION DURING CARDIAC SURGERY
    HENRY SPOTNITZ; Fiscal Year: 2005
    ....
  8. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2008
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  9. Chronic Ischemic Mitral Regurgitation: Failure of a Mitral Control System?
    D Craig Miller; Fiscal Year: 2010
    ..This research is likely to lead to improved surgical treatments and medical therapies based on rational criteria, not only for chronic ischemic mitral regurgitation, but for other causes of mitral regurgitation, as well. ..
  10. VENTRICULAR DYNAMICS FROM SURGICALLY INSERTED MARKERS
    D Miller; Fiscal Year: 2007
    ..The knowledge gained should translate directly into more rational surgical as well as medical treatments for patients after an MI with CHF, CIMR, or both. ..
  11. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  12. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  13. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  14. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  15. Endocytosis in cardiac myocytes
    Ion Jovin; Fiscal Year: 2005
    ..The discoverry of polypeptides that guide macromolecules to specific cellular organelles or compartments can have profound implications for understanding microbial invasion and for refining gene therapy. ..
  16. The long-term consequences of postoperative acute kidney injury
    Areef Ishani; Fiscal Year: 2008
    ..Once the AKI- associated burden of CKD has been precisely estimated and modifiable factors have been identified, clinical trials can be performed that may reduce this disease burden. [unreadable] [unreadable] [unreadable]..
  17. TRAINING GRANT IN MOLECULAR CARDIOLOGY
    Mark Entman; Fiscal Year: 2008
    ..This integrated design has consistently proven to be effective in providing successful independent and competitive investigators in molecular biology of cardiovascular medicine. ..
  18. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  19. PATHOBIOLOGY OF CEREBRAL CAVERNOUS MALFORMATION
    Richard Lifton; Fiscal Year: 2002
    ..They have established a collection of these lesions and have begun developing cell cultures of different cell lines from lesions in order to pursue this aim. ..
  20. Cardiac Surgical Ischemia: Biophysical Aspects
    Irvin Krukenkamp; Fiscal Year: 2006
    ..abstract_text> ..
  21. Grape Seed Extract-Cardiac Impact and Drug Interaction
    Steven Bolling; Fiscal Year: 2005
    ..Considering the increasing use of this botanical extract, improved knowledge of safety and efficacy is imperative. ..