corneal transplantation

Summary

Summary: Partial or total replacement of the cornea from one human or animal to another.

Top Publications

  1. ncbi Descemet's stripping with endothelial keratoplasty in 200 eyes: Early challenges and techniques to enhance donor adherence
    Francis W Price
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 32:411-8. 2006
  2. ncbi Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation
    Yutaka Ishino
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 45:800-6. 2004
  3. doi Corneal transplantation
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Lancet 379:1749-61. 2012
  4. doi Attenuation of ocular hypertension with the use of topical loteprednol etabonate 0.5% in steroid responders after corneal transplantation
    Edward J Holland
    Cincinnati Eye Institute, OH, USA
    Cornea 28:1139-43. 2009
  5. ncbi Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cornea 22:273-81. 2003
  6. doi Descemet stripping with automated endothelial keratoplasty for bullous keratopathies secondary to argon laser iridotomy--preliminary results and usefulness of double-glide donor insertion technique
    Akira Kobayashi
    Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cornea 27:S62-9. 2008
  7. doi Endothelial cell loss after Descemet's stripping endothelial keratoplasty in a large prospective series
    Mark A Terry
    Corneal Services, Devers Eye Institute, Portland, Oregon 97210, USA
    Ophthalmology 115:488-496.e3. 2008
  8. ncbi Suture technique for Descemet stripping and endothelial keratoplasty
    Marian Sue Macsai
    Division of Ophthalmology, Evanston Northwestern Healthcare, Evanston, IL, USA
    Cornea 26:1123-6. 2007
  9. doi Busin Guide vs Forceps for the Insertion of the Donor Lenticule in Descemet Stripping Automated Endothelial Keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Ophthalmol 147:220-226.e1. 2009
  10. pmc The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
    M Halberstadt
    Department of Ophthalmolgy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Ophthalmol 86:646-52. 2002

Detail Information

Publications289 found, 100 shown here

  1. ncbi Descemet's stripping with endothelial keratoplasty in 200 eyes: Early challenges and techniques to enhance donor adherence
    Francis W Price
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 32:411-8. 2006
    ..To describe early challenges and techniques to promote donor tissue adherence in Descemet's stripping with endothelial keratoplasty (DSEK)...
  2. ncbi Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation
    Yutaka Ishino
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 45:800-6. 2004
    ..To achieve this, a matrix that can serve as a carrier for cHCECs is needed. The present study was conducted to examine the feasibility of using amniotic membrane (AM) as a carrier for this application...
  3. doi Corneal transplantation
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Lancet 379:1749-61. 2012
    b>Corneal transplantation or keratoplasty has developed rapidly in the past 10 years...
  4. doi Attenuation of ocular hypertension with the use of topical loteprednol etabonate 0.5% in steroid responders after corneal transplantation
    Edward J Holland
    Cincinnati Eye Institute, OH, USA
    Cornea 28:1139-43. 2009
    ..5% ophthalmic suspension as second-line rescue therapy after corneal transplantation.
  5. ncbi Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cornea 22:273-81. 2003
    ..This has changed with the recent discovery of the lymphatic endothelial markers vascular endothelial growth factor receptor 3, LYVE-1 (a lymphatic endothelium-specific hyaluronan receptor), Prox 1, and Podoplanin...
  6. doi Descemet stripping with automated endothelial keratoplasty for bullous keratopathies secondary to argon laser iridotomy--preliminary results and usefulness of double-glide donor insertion technique
    Akira Kobayashi
    Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cornea 27:S62-9. 2008
    ..We developed a novel nonfolding donor insertion technique using a Busin glide and an intraocular lens (IOL) sheet glide and evaluated post-DSAEK outcomes for ALI-induced BK using several insertion techniques...
  7. doi Endothelial cell loss after Descemet's stripping endothelial keratoplasty in a large prospective series
    Mark A Terry
    Corneal Services, Devers Eye Institute, Portland, Oregon 97210, USA
    Ophthalmology 115:488-496.e3. 2008
    ..To report the donor endothelial cell loss in the first year after Descemet's stripping endothelial keratoplasty (DSEK) for the treatment of endothelial dysfunction...
  8. ncbi Suture technique for Descemet stripping and endothelial keratoplasty
    Marian Sue Macsai
    Division of Ophthalmology, Evanston Northwestern Healthcare, Evanston, IL, USA
    Cornea 26:1123-6. 2007
    ..To describe a suture technique for Descemet stripping and endothelial keratoplasty (DSEK)...
  9. doi Busin Guide vs Forceps for the Insertion of the Donor Lenticule in Descemet Stripping Automated Endothelial Keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Ophthalmol 147:220-226.e1. 2009
    ..To compare two insertion methods in Descemet stripping automated endothelial keratoplasty (DSAEK): Busin guide-assisted vs Forceps-assisted insertion of the corneal lenticule graft...
  10. pmc The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
    M Halberstadt
    Department of Ophthalmolgy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Ophthalmol 86:646-52. 2002
    ..To evaluate the outcome of corneal grafting in patients with stromal keratitis of herpetic (HSK) and non-herpetic origin, using predefined diagnostic criteria and standardised postoperative therapeutic strategies...
  11. doi Descemet stripping endothelial keratoplasty: effect of the surgical procedure on corneal optics
    Srinivas K Rao
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, People s Republic of China
    Am J Ophthalmol 145:991-6. 2008
    To determine the changes in corneal optical performance after posterior lamellar corneal transplantation.
  12. doi Descemet-stripping automated endothelial keratoplasty by using suture for donor insertion
    Vincenzo Sarnicola
    Misericordia Hospital, Grosseto, Italy
    Cornea 27:825-9. 2008
    ..To describe a new technique for donor insertion in cases of Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  13. doi Refractive change after descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter
    Bokkwan Jun
    Corneal and Refractive Surgery Services, Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Cornea 28:19-23. 2009
    ..The purpose of this study was to evaluate the refractive change after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and its correlation with graft thickness and diameter...
  14. doi Descemet-stripping automated endothelial keratoplasty: six-month results in a prospective study of 100 eyes
    Edwin S Chen
    Devers Eye Institute, Portland, OR 97210, USA
    Cornea 27:514-20. 2008
    ..To report 6-month results in a large, prospective study of Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  15. doi Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview
    Gary S L Peh
    Singapore Eye Research Institute, Singapore
    Transplantation 91:811-9. 2011
    ..Although current corneal transplantation is more than 90% successful at 1 year, longer term results are not as encouraging with approximately 70% ..
  16. ncbi Surgical management of scleral defects
    Altan A Ozcan
    Department of Ophthalmology, Cukurova University, Faculty of Medicine, Adana, Turkey
    Cornea 24:308-11. 2005
    ..To evaluate the results of surgical management of scleral defects using fascia lata, cornea, and sclera as graft materials...
  17. doi A rabbit anterior cornea replacement derived from acellular porcine cornea matrix, epithelial cells and keratocytes
    Kunpeng Pang
    Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan, People s Republic of China
    Biomaterials 31:7257-65. 2010
    ..These results suggested that the APCM developed by using SDS might be a suitable scaffold for cornea tissue engineering...
  18. ncbi Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix
    S C Tseng
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA
    J Cell Physiol 179:325-35. 1999
    ..It may also explain in part why fetal wound healing is scarless...
  19. ncbi B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts
    Junko Hori
    Department of Ophthalmology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    J Immunol 177:5928-35. 2006
    ..B7-H1 expressed on corneal endothelial cells maintains long-term acceptance of the corneal allografts by inducing apoptosis of effector T cells within the cornea...
  20. ncbi Descemet membrane endothelial keratoplasty (DMEK)
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands
    Cornea 25:987-90. 2006
    ..To describe Descemet membrane endothelial keratoplasty (DMEK) with organ cultured Descemet membrane (DM) in a human cadaver eye model and a patient with Fuchs endothelial dystrophy...
  21. doi Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 184:535-9. 2010
    ..Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds...
  22. doi Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Ophthalmology 115:1525-33. 2008
    ....
  23. doi Endothelial keratoplasty: historical perspectives, current techniques, future directions
    Linda Rose
    Cornea and External Diseases, University of New Mexico, Albuquerque, NM, USA
    Can J Ophthalmol 44:401-5. 2009
    ..In this review we discuss the history of EK, recent advances that have led to its widespread use, limits and complications of the procedure, and areas for future improvement...
  24. doi Modified air-assisted descemetorhexis for Descemet-stripping automated endothelial keratoplasty
    Jodhbir S Mehta
    Singapore National Eye Centre, Singapore
    J Cataract Refract Surg 34:889-91. 2008
    ....
  25. doi Corneal profile analysis after Descemet stripping endothelial keratoplasty and its relationship to postoperative hyperopic shift
    Huck A Holz
    John A Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    J Cataract Refract Surg 34:211-4. 2008
    ....
  26. ncbi Descemet's stripping endothelial keratoplasty
    Marianne O Price
    Cornea Research Foundation of America, Indianapolis, IN, USA
    Curr Opin Ophthalmol 18:290-4. 2007
    ..Familiarity with recent advances in techniques and instrumentation can help reduce the initially steep learning curve and incidence of complications...
  27. ncbi SEB combined with IL-1ra could prolong the survival of the rat allografts in high-risk corneal transplantation
    Y Jie
    Beijing Institute of Ophthalmology and the Tongren Eye Bank, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Transplant Proc 36:3267-71. 2004
    To determine whether the superantigen Staphylococcal enterotoxin B (SEB) combined with interleukin-1 receptor antagonist (IL-1ra) prolong allograft survival better than individual agents in high-risk corneal transplantation in a rat model.
  28. doi The use of postoperative slit-lamp optical coherence tomography to predict primary failure in descemet stripping automated endothelial keratoplasty
    Carolyn Y Shih
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, New York, USA
    Am J Ophthalmol 147:796-800, 800.e1. 2009
    ....
  29. pmc Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation
    Takaaki Hattori
    Schepens Eye Research Institute, Boston, MA 02114, USA
    J Leukoc Biol 91:621-7. 2012
    ..We therefore used the murine model of corneal transplantation to address this, as these allografts are rejected in an indirect pathway-dominant manner...
  30. pmc Arginine depletion as a mechanism for the immune privilege of corneal allografts
    Hongmei Fu
    Section of Immunobiology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Eur J Immunol 41:2997-3005. 2011
    ..These data show that arginase is functional in the cornea and contributes to the immune privilege of the eye, and that modulation of arginase contributes to graft survival...
  31. pmc FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations
    K Mayer
    Eye Hospital, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Br J Ophthalmol 88:915-9. 2004
    ..The authors investigated the potency of FTY720 in inhibiting allograft rejection in the rat model of orthotopic allogeneic penetrating keratoplasty...
  32. doi Development and characterization of a full-thickness acellular porcine cornea matrix for tissue engineering
    Liqun Du
    Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China
    Artif Organs 35:691-705. 2011
    ..The matrix is biocompatible with cornea-derived cells and has potential for use in corneal transplantation and tissue-engineering applications.
  33. doi Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering
    Yoshihide Hashimoto
    Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
    Biomaterials 31:3941-8. 2010
    ..The decellularized corneas obtained through HHP could be useful as a corneal scaffold for tissue regeneration...
  34. doi Descemet membrane automated endothelial keratoplasty: hybrid technique combining DSAEK stability with DMEK visual results
    Matthew B McCauley
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 35:1659-64. 2009
    ..The Descemet membrane automated endothelial keratoplasty transplantation technique combines the superior vision potential of Descemet membrane endothelial keratoplasty with the easier insertion and manipulation of DSAEK...
  35. doi Risk factors, clinical features, and outcomes of recurrent fungal keratitis after corneal transplantation
    Weiyun Shi
    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Ophthalmology 117:890-6. 2010
    To study the risk factors, clinical features, and treatment of recurrent fungal keratitis after corneal transplantation.
  36. ncbi Paradigm shifts in corneal transplantation
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Ann Acad Med Singapore 38:332-8. 2009
    Conventional corneal transplantation, in the form of penetrating keratoplasty (PK), involves full-thickness replacement of the cornea, and is a highly successful procedure. However, the cornea is anatomically a multi-layered structure...
  37. pmc Differential roles of direct and indirect allorecognition pathways in the rejection of skin and corneal transplants
    Florence Boisgerault
    Department of Surgery, Transplantation Unit, Cellular and Molecular Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transplantation 87:16-23. 2009
    ..It is generally accepted that all transplants are not rejected in the same fashion. However, the extrinsic and intrinsic factors that control the recognition and rejection of a particular allograft by the host are not well characterized...
  38. ncbi The profile of repeated corneal transplantation
    V Bersudsky
    Department of Ophthalmology, Western Galilee-Nahariya Medical Center, Nahariya, Israel
    Ophthalmology 108:461-9. 2001
    PURPOSE: To evaluate the primary indications for corneal transplantation in patients with repeated keratoplasties, graft survival, the causes and risk factors for failure. SETTING: Tertiary referral care center...
  39. ncbi Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation
    Jun Shimazaki
    The Department of Ophthalmology, Tokyo Dental College, 5 11 13 Sugano, Ichikawa shi, Chiba 272 8513, Japan
    Transplantation 78:216-20. 2004
    ..This single-center, case-controlled study was conducted to show the efficacy and safety of corneal transplantation using corneas from foreign donors.
  40. ncbi Deep anterior lamellar keratoplasty combined with autologous limbal stem cell transplantation in unilateral severe chemical injury
    Rajesh Fogla
    Sankara Nethralaya, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India
    Cornea 24:421-5. 2005
    ....
  41. ncbi Immune privilege and angiogenic privilege of the cornea
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Chem Immunol Allergy 92:50-7. 2007
    ..an immune-privileged site and tissue, enabling the extraordinary success of histologically incompatible corneal transplantation. Recent evidence indicates that there is considerable overlap in the molecular mechanisms maintaining ..
  42. ncbi Corneal graft rejection
    Anita Panda
    Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Surv Ophthalmol 52:375-96. 2007
    ..New systemic pharmacological interventions recommended in corneal transplantation need further evaluation and detailed guidelines...
  43. ncbi Transplantation of Descemet's membrane carrying viable endothelium through a small scleral incision
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands
    Cornea 21:415-8. 2002
    ..To design a technique for transplantation of the Descemet's membrane (DM) as a carrier for its endothelium, while maintaining the low-astigmatic recipient anterior corneal curvature...
  44. doi Dendritic cell physiology and function in the eye
    John V Forrester
    Section of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Immunol Rev 234:282-304. 2010
    ..This approach has considerable potential for use in translational clinical therapy to prevent sight-threatening disease caused by ocular inflammation...
  45. ncbi Patient satisfaction after corneal transplantation
    E Uiters
    Department of Health Education, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Cornea 20:687-94. 2001
    To determine the relationship between objective and subjective outcome measures and patient satisfaction after corneal transplantation.
  46. doi Corneal graft surgery combined with subconjunctival bevacizumab (avastin)
    Richard J Symes
    Department of Ophthalmology, Frimley Park Hospital, Camberley, Surrey, United Kingdom
    Cornea 29:691-3. 2010
    ..To describe the use of subconjunctival bevacizumab (Avastin) as an adjunctive treatment in a vascularized cornea at the time of lamellar keratoplasty to reduce the risk of graft rejection...
  47. ncbi Graft failure IV. Immunologic mechanisms of corneal transplant rejection
    Eva Marie Chong
    Cornea Service, Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Int Ophthalmol 28:209-22. 2008
    b>Corneal transplantation is the oldest and the most common form of solid tissue transplantation in humans. Immunologic graft rejection is one of the main causes of short and long-term graft failure...
  48. ncbi The immune response to corneal allograft requires a site-specific draining lymph node
    Jarmila Plsková
    Department of Ophthalmology, University of Aberdeen, Medical School Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Transplantation 73:210-5. 2002
    ..In this study we have investigated further the role of the DLN and spleen in corneal graft rejection in mice...
  49. doi Risk factors for human corneal graft failure within the Australian corneal graft registry
    Keryn A Williams
    Department of Ophthalmology, Flinders University of South Australia, Adelaide, South Australia, Australia
    Transplantation 86:1720-4. 2008
    Our aims were to examine graft survival and visual outcome after full-thickness corneal transplantation.
  50. doi The Boston type I keratoprosthesis: improving outcomes and expanding indications
    Anthony J Aldave
    Cornea Service, The Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Ophthalmology 116:640-51. 2009
    ..To report the usefulness of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal opacification, corneal limbal stem cell failure, or both in a large single-surgeon series...
  51. ncbi The impact of corneal allograft rejection on the long-term outcome of corneal transplantation
    Douglas J Coster
    Department of Ophthalmology, Flinders University, Bedford Park, Adelaide, SA 5042, Australia
    Am J Ophthalmol 140:1112-22. 2005
    To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for alternative ..
  52. doi Comparison of outcomes of lamellar keratoplasty and penetrating keratoplasty in keratoconus
    Daphne C Y Han
    Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 148:744-751.e1. 2009
    ..To compare outcomes after penetrating keratoplasty (PK) and two techniques of deep anterior lamellar keratoplasty (DALK) in patients with keratoconus...
  53. ncbi Human fibrin tissue adhesive for sutureless lamellar keratoplasty and scleral patch adhesion: a pilot study
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Ophthalmology 110:2168-72. 2003
    ..To determine whether a fibrin adhesive can facilitate the performance of sutureless lamellar keratoplasty and attachment of amnion to bare sclera...
  54. ncbi Cataract progression and treatment following posterior lamellar keratoplasty
    Marianne O Price
    Cornea Research Foundation of America, Indianapolis, IN, USA
    J Cataract Refract Surg 30:1310-5. 2004
    ..To describe the development and treatment of cataracts following posterior lamellar keratoplasty (PLK) in phakic eyes with Fuchs' endothelial dystrophy...
  55. ncbi Tissue engineering of the cornea
    Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Cornea 22:S28-34. 2003
    ..of the cornea represents a paradigm shift in medical treatment to overcome the present disadvantages of corneal transplantation, primarily immune rejection and the shortage of donor corneas...
  56. ncbi Candida interface keratitis after deep anterior lamellar keratoplasty: clinical, microbiologic, histopathologic, and confocal microscopic reports
    Mozhgan Rezaei Kanavi
    Labbafinejad Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran
    Cornea 26:913-6. 2007
    ..To report the clinical, histopathologic, microbiologic, and confocal microscopic features of Candida keratitis after deep anterior lamellar keratoplasty (DALK)...
  57. ncbi Preliminary clinical results of Descemet membrane endothelial keratoplasty
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Laan Op Zuid 390, Rotterdam, The Netherlands
    Am J Ophthalmol 145:222-227. 2008
    ..5-mm incision, tentatively named Descemet membrane endothelial keratoplasty (DMEK), for the management of corneal endothelial disorders...
  58. pmc IL-17 promotes immune privilege of corneal allografts
    Khrishen Cunnusamy
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 185:4651-8. 2010
    ..These findings demonstrate that IL-17A is not required for corneal allograft rejection and may instead contribute to the immune privilege of corneal allografts...
  59. ncbi Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice
    Lucia Kuffova
    Department of Ophthalmology, Institute of Molecular Sciences, Medical School Foresterhill, University of Aberdeen, Aberdeen, Scotland
    J Immunol 180:1353-61. 2008
    ..Ag trafficking from the cornea and T effector cell activation in secondary lymphoid tissue after corneal transplantation. In preliminary experiments, the central cornea was shown to contain a population of CD45(+), CD11b(+), ..
  60. doi Aqueous humor alloreactive cell phenotypes, cytokines and chemokines in corneal allograft rejection
    T H Flynn
    Department of Ocular Immunology, UCL Institute of Ophthalmology, London, UK
    Am J Transplant 8:1537-43. 2008
    ..Aqueous humor samples offer a unique opportunity to analyze components of the allogeneic response in direct contact with donor tissue but without artifacts inherent in examination of tissue...
  61. ncbi Epidemiology and risk factors for corneal graft rejection
    D Sellami
    Department of Ophthalmology, CHU Habib Bourguiba, 3029 Sfax, Tunisia
    Transplant Proc 39:2609-11. 2007
    ..The aim of this study was to evaluate the frequency and main risk factors for corneal graft rejection...
  62. doi Suture-assisted vs forceps-assisted insertion of the donor lenticula during Descemet stripping automated endothelial keratoplasty
    Igor Kaiserman
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada
    Am J Ophthalmol 145:986-990. 2008
    ..To compare a new insertion method using a suture with the standard forceps-assisted insertion of the lamellar corneal graft in Descemet stripping automated endothelial keratoplasty (DSAEK)...
  63. ncbi Return of human corneal sensitivity after penetrating keratoplasty
    W D Mathers
    Department of Ophthalmology, University of Arizona Health Science Center, Tucson
    Arch Ophthalmol 106:210-1. 1988
    ..None of the eight patients with herpes simplex keratitis had a sensation recorded further than 0.5 mm from the wound margin...
  64. ncbi Using basement membrane of human amniotic membrane as a cell carrier for cultivated cat corneal endothelial cell transplantation
    Wu Wencan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou City, China
    Curr Eye Res 32:199-215. 2007
    ..To study the feasibility of using basement membrane of human amniotic membrane (BMHAM) as a carrier for transplantation of cultivated cat corneal endothelial cells (cCCECs)...
  65. ncbi Component surgery of the cornea
    Shigeto Shimmura
    Department of Ophthalmology, Tokyo Dental College, 5 11 13 Sugano, Ichikawa shi, Chiba 272 8513, Japan
    Cornea 23:S31-5. 2004
    ..Further refinements in technology will certainly take the limits of corneal surgery to new horizons...
  66. pmc 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival
    Sarah S Zaher
    Department of Immunology, Division of Medicine, Imperial College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:2640-8. 2011
    ..This study was conducted to examine the effect of kynurenines, the products of tryptophan breakdown and known to act directly on T lymphocytes, on corneal graft survival...
  67. ncbi Mycobacterium chelonae interface infection after endokeratoplasty
    Massimo Busin
    Casa di Cura Villa Serena, Forli, Italy
    Am J Ophthalmol 135:393-5. 2003
    ..To report a case of interface infection by Mycobacterium chelonae in a patient who underwent endokeratoplasty...
  68. doi GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts
    Junko Hori
    Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:6556-65. 2010
    ..The present study was conducted to investigate the role of this pathway and Treg in establishing immune privilege status for corneal allografts...
  69. pmc The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model
    Masahiro Omoto
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e47716. 2012
    ..We examined the efficacy of the semaphorin 3A inhibitor, SM-345431, in promoting regeneration of peripheral nerves in a mouse corneal transplantation model.
  70. pmc Amniotic membrane transplantation in the management of conjunctival malignant melanoma and primary acquired melanosis with atypia
    D Paridaens
    Rotterdam Eye Hospital, Oculoplastic Service, Rotterdam Eye Hospital, The Netherlands
    Br J Ophthalmol 85:658-61. 2001
    ..The transparency of amniotic membrane allows for monitoring of tumour recurrence, which is-together with superior cosmesis-an advantage over thicker (for example, buccal) mucous membrane grafts...
  71. doi Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs
    Hong Qi
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Eye Res 87:580-6. 2008
    ....
  72. pmc Tectonic lamellar keratoplasty with acellular corneal stroma in high-risk corneal transplantation
    Naiyang Li
    State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, P R China
    Mol Vis 17:1909-17. 2011
    ..TLKP) is a primary surgical procedure to improve the condition of the recipient bed in high-risk corneal transplantation. It is usually performed for a secondary optical penetrating keratoplasty (PKP)...
  73. doi Entertainment-education and recruitment of cornea donors: the role of emotion and issue involvement
    Hyuhn Suhck Bae
    Department of Media and Communication, Yeungnam University, 214 1 Dae Dong, Gyungsan si, Gyungbuk 712 749, South Korea
    J Health Commun 13:20-36. 2008
    ....
  74. ncbi [Expression of regulatory T cells and related cytokines in mice allogenic corneal transplantation rejection]
    Xin Wang
    Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China
    Zhonghua Yan Ke Za Zhi 45:1118-26. 2009
    ..To study the changes of CD4(+)CD25(+) and CD8(+)CD103(+) regulatory T cells and their relevant cytokines in corneal allograft transplantation in mice...
  75. pmc Non-specific tolerance induced by staphylococcal enterotoxin B in treating high risk corneal transplantation in rats
    Y Jie
    Beijing Institute of Ophthalmology, Tongren Eye Center, Tongren Hospital, Capital University of Medical Sciences, China
    Br J Ophthalmol 89:364-8. 2005
    ..To explore the role of staphylococcal enterotoxin B (SEB) in treating high risk corneal keratoplasty in rats...
  76. doi Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation
    Jun Shimazaki
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Am J Ophthalmol 152:33-39.e1. 2011
    Immunologic rejection remains a major cause of graft failure in high-risk corneal transplantation. This study was conducted to elucidate the efficacy and safety of systemic cyclosporine (CsA) in high-risk corneal transplantation.
  77. pmc Donor age and corneal endothelial cell loss 5 years after successful corneal transplantation. Specular microscopy ancillary study results
    Jonathan H Lass
    Cornea Donor Study Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Ophthalmology 115:627-632.e8. 2008
    To determine whether endothelial cell loss 5 years after successful corneal transplantation is related to the age of the donor.
  78. doi Donor tissue preparation for Descemet membrane endothelial keratoplasty
    Jessica T Lie
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands
    J Cataract Refract Surg 34:1578-83. 2008
    ..To evaluate a technique for preparing a donor Descemet membrane carrying autologous endothelium for transplantation in Descemet membrane endothelial keratoplasty (DMEK)...
  79. pmc Outcome of corneal transplantation
    Melissa M Brown
    Br J Ophthalmol 86:2-3. 2002
  80. doi Evaluation of topical ciclosporin 0.05% for prevention of rejection in high-risk corneal grafts
    M Unal
    Akdeniz University Medical Faculty, Department of Ophthalmology, Antalya, Turkey
    Br J Ophthalmol 92:1411-4. 2008
    ..1%, and 22 eyes (group 2) were treated with dexamethasone only. The clinical outcome of penetrating keratoplasty was evaluated by the rate of rejection-free graft survival and graft survival evaluation by the Kaplan-Meier logrank test...
  81. ncbi Alternatives to allograft corneal transplantation
    Vishal Jhanji
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Curr Opin Ophthalmol 21:301-9. 2010
    b>Corneal transplantation is the most commonly performed solid organ transplantation in the world...
  82. doi Efficacy of Routine Notification and Request on reducing corneal transplantation wait times in Canada
    Mahta Rasouli
    School of Medicine, Faculty of Health Sciences, Queen s University, Kingston, Ont
    Can J Ophthalmol 44:31-5. 2009
    ..To determine whether the implementation of Routine Notification and Request (RNR) has been effective in increasing the amount of donor corneal tissue available and reducing wait times for corneal transplant (CT) surgeries...
  83. pmc In vivo evaluation of a novel scaffold for artificial corneas prepared by using ultrahigh hydrostatic pressure to decellularize porcine corneas
    Shuji Sasaki
    Department of Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Vis 15:2022-8. 2009
    ..To evaluate the stability and biocompatibility of artificial corneal stroma that was prepared by using ultrahigh hydrostatic pressurization treatment to decellularize corneas...
  84. ncbi Survival of cultured allogeneic limbal epithelial cells following corneal repair
    Justin R Sharpe
    Blond McIndoe Centre, Queen Victoria Hospital, East Grinstead, and Department of Pharmacy and Biomolecular Sciences, University of Brighton, UK
    Tissue Eng 13:123-32. 2007
    ....
  85. doi Lamellar keratoplasty with a graft of lyophilized acellular porcine corneal stroma in the rabbit
    Xu Chu Lin
    Department of Oral Histology and Pathology, College of Stomatology, Shanxi, China
    Vet Ophthalmol 11:61-6. 2008
    ..To evaluate the efficacy of lamellar keratoplasty in the rabbit using a graft of lyophilized acellular porcine corneal stroma (APCS)...
  86. ncbi Corneal transplant tolerance of cryopreservation
    I Brunette
    Department of Ophthalmology, University of Montreal, Montreal, Canada
    Cornea 20:590-6. 2001
    ..Although we do not recommend cryopreservation of corneas for elective surgery, we consider that cryopreserved corneas can be very useful in emergency situations when tissue availability is a problem...
  87. ncbi Are corneal cells susceptible to antibody-mediated killing in corneal allograft rejection?
    Sylvia L Hargrave
    Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas, TX 75235 9057, USA
    Transpl Immunol 11:79-89. 2003
    The precise role of antibodies in corneal transplantation is controversial. Clinical and experimental evidence both supports and refutes the contribution of donor-derived alloantibody in corneal allograft rejection...
  88. ncbi Refractive surgery after corneal transplantation
    Daniel H Chang
    Minnesota Eye Consultants, Minneapolis, Minnesota, USA
    Curr Opin Ophthalmol 16:251-5. 2005
    Many patients who have undergone corneal transplantation are unable to achieve satisfactory visual acuity with spectacle and contact lens correction alone...
  89. doi MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice
    Jun Yamada
    Department of Ophthalmology, Meiji University of Integrative Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 50:2139-46. 2009
    ..The present study was designed to determine the role of IFN-gamma and IL-17 in the rejection by C57BL/6 hosts, which display high rejection rates...
  90. doi Perilimbal bevacizumab injection for interface neovascularization after deep anterior lamellar keratoplasty
    Alireza Foroutan
    Department of Ophthalmology, Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
    Cornea 29:1268-72. 2010
    ..To evaluate the effect of perilimbal bevacizumab injection on neovascularization at the interface of donor and recipient tissues after deep anterior lamellar keratoplasty (DALK)...
  91. doi Antibody-based immunosuppressive agents for corneal transplantation
    M A Thiel
    Department of Ophthalmology, Cantonal Hospital Lucerne, 6000 Lucerne 16, Switzerland
    Eye (Lond) 23:1962-5. 2009
    ..immunosuppressive option in solid organ transplantation, there are only very few reports with regard to corneal transplantation. The following review explains some of the important aspects of engineered antibody-based therapeutic ..
  92. ncbi Corneal epithelial rejection in the rat
    Francisco C Figueiredo
    Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Invest Ophthalmol Vis Sci 43:729-36. 2002
    ..To investigate clinical and histologic changes in the epithelium during corneal graft rejection in the rat...
  93. doi Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation
    Joo Youn Oh
    Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea
    Vet Ophthalmol 12:78-82. 2009
    ..05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms...
  94. ncbi CD4+ T-cell-independent rejection of corneal allografts
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Transplantation 81:1171-8. 2006
    ..Several studies suggest that a significant number of corneal allografts undergo rejection in the absence of CD4 T cells. This study examined the role of CD4 T cell-independent mechanisms of corneal allograft rejection...
  95. doi A pathogenic role of IL- 17 at the early stage of corneal allograft rejection
    Haiyong Chen
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China
    Transpl Immunol 21:155-61. 2009
    ..However, the role of these cells in organ allograft rejection remains largely unknown. In this study, we investigate whether Th17 cells participate in allogeneic corneal rejection in a mouse model...
  96. doi Corneal grafting and banking
    Niels Ehlers
    Danish Eye Bank, Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark
    Dev Ophthalmol 43:1-14. 2009
    b>Corneal transplantation was conceptualized at the end of the 18th century, but it took more than 100 years before human corneal grafting was introduced...
  97. doi Feasibility study of lamellar keratoplasty in a murine model
    Ting Huang
    Key Laboratory of Ophthalmology of the Ministry of Education and Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    Ocul Immunol Inflamm 17:257-64. 2009
    ..There is debate about relative merits of each approach, but experimental comparisons have never been performed in animal models. Therefore, the authors developed a murine LK model...
  98. ncbi Role of CD4+ and CD8+ T cells in allorecognition: lessons from corneal transplantation
    F Boisgerault
    Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 167:1891-9. 2001
    b>Corneal transplantation represents an interesting model to investigate the contribution of direct vs indirect Ag recognition pathways to the alloresponse. Corneal allografts are naturally devoid of MHC class II+ APCs...
  99. doi Regeneration of functional nerves within full thickness collagen-phosphorylcholine corneal substitute implants in guinea pigs
    Christopher R McLaughlin
    University of Ottawa Eye Institute, The Ottawa Hospital, General Campus, 501 Smyth Road, Ottawa, ONK1H 8L6, Canada
    Biomaterials 31:2770-8. 2010
    ..We show that ECM mimetic materials can promote regeneration of corneal cells and functional nerves. The simplicity in fabrication and demonstrated functionality shows potential for ECM substitutes in future clinical applications...
  100. ncbi Nitrosative stress and corneal transplant endothelial cell death during acute graft rejection
    Jean Louis Bourges
    INSERM, UMRS, Team 17, Physiopathology of Ocular Diseases, Therapeutic Innovations, Paris, France
    Transplantation 84:415-23. 2007
    ..Nitrosative stress takes place in endothelial cells (EC) during corneal acute graft rejection. The purpose of this study was to evaluate the potential role of peroxynitrite on corneal EC death...
  101. doi Anterior lamellar keratoplasty over penetrating keratoplasty for optical, therapeutic, and tectonic indications: a case series
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Am J Ophthalmol 147:697-702.e2. 2009
    ..To report a consecutive case series of patients who underwent anterior lamellar keratoplasty (ALK) over a preexisting penetrating keratoplasty (PK)...

Research Grants85

  1. CELL CYCLE OF THE CORNEAL ENDOTHELIUM
    Nancy Joyce; Fiscal Year: 2000
    ..dysfunction is currently medically untreatable and restoration of vision can only be accomplished by corneal transplantation. Our long- term goal is to develop medical treatments to promote healing of stressed corneal endothelium...
  2. Corneal Lymphatics & Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2011
    ..to HSV-1 infection operates thru a unique pathway distinct from what has been described following corneal transplantation. Specifically, we have found a robust vascular endothelial growth factor (VEGF) A response by corneal ..
  3. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2010
    ..g., LASEK, PRK, corneal transplantation, and Dry Eye...
  4. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2010
    ..Additionally, corneal transplantation offers an excellent model for lymphatic research because it allows for (i) functional lymphatic cell ..
  5. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2009
    ..Additionally, corneal transplantation offers an excellent model for lymphatic research because it allows for (i) functional lymphatic cell ..
  6. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2009
    ..Additionally, corneal transplantation offers an excellent model for lymphatic research because it allows for (i) functional lymphatic cell ..
  7. The Role of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal Dys
    Ula V Jurkunas; Fiscal Year: 2010
    ..b>Corneal transplantation is the only currently available measure to restore lost vision...
  8. The role of PPAR{gamma} ligands in corneal wound healing and optics
    Krystel R Huxlin; Fiscal Year: 2010
    ..disruption to normal corneal structure and function, whether from infection, laser refractive surgery, corneal transplantation, ocular trauma (chemical or physical) or corneal dystrophies...
  9. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2010
    ..remains the major cause of infectious blinding disease in the US, with the only effective treatment being corneal transplantation. HSK is triggered by reactivation of herpes simplex virus type 1 (HSV-1) from a latent state that is ..
  10. Guiding The Treatment of Anterior Eye Diseases with Optical Coherence Tomography
    David Huang; Fiscal Year: 2010
    ..the corneas with a procedure that combines the precision of OCT and lasers instead of traditional corneal transplantation, which is associated with slow visual recovery and risks of transplant rejection...
  11. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2010
    ..application to further characterize the molecular and cellular facets of host immunity in high-risk corneal transplantation. High-risk corneal grafts are characterized by their rapid and high frequency of rejection...
  12. Noninvasive 3D Microscopic Studies of Corneal Elasticity and Collagen Structure
    Tibor Juhasz; Fiscal Year: 2010
    ..biomechanics, such as keratoconus and post-LASIK ectasia affect millions of people and often necessitate corneal transplantation. Corneal biomechanics also plays an increasingly recognized role in the post-operative results of ..
  13. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..It is a leading indication for corneal transplantation within the United States...
  14. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor L Perez; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE The main treatment for blindness caused by severe corneal scarring is corneal transplantation. Unfortunately, in patients where corneal scarring is associated with blood vessel formation, the ..
  15. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor L Perez; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE The main treatment for blindness caused by severe corneal scarring is corneal transplantation. Unfortunately, in patients where corneal scarring is associated with blood vessel formation, the ..
  16. CORNEA
    William Bourne; Fiscal Year: 2000
    ..endothelium and 2) to develop a method for permanent corneal storage to improve the overall results of corneal transplantation, the treatment for endothelial failure...
  17. Mapping and cloning genes for Keratoconus
    Bassem Bejjani; Fiscal Year: 2007
    ..Although KC is an uncommon condition, it is the single most common cause for corneal transplantation in North America and thus carries substantial morbidity and expense...
  18. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2010
    ..b>Corneal transplantation is often needed to restore corneal clarity...
  19. Device for Facilitating Corneal Transplantation
    YICHIEH SHIUEY; Fiscal Year: 2006
    ..Although corneal transplantation surgery is generally considered to be successful, the most common technique, penetrating keratoplasty (PK)..
  20. New Biomaterials for Sutureless Ophthalmic Surgeries
    Mark Grinstaff; Fiscal Year: 2005
    ..Will a biodendrimer secure a corneal autograft? Corneal perforation and corneal transplantation are two models of corneal tissue injury that are ideal for testing new tissue sealants...
  21. Early Detection of Keratoconus
    Ronald H Silverman; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Keratoconus (KC) is a corneal dystrophy will in many cases ultimately require corneal transplantation to maintain vision...
  22. IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATION
    JOHN KRIESEL; Fiscal Year: 2002
    ..Acute and recurrent herpes simplex keratitis are leading indications for corneal transplantation in this country...
  23. Early Detection of Keratoconus
    Ronald Silverman; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Keratoconus (KC) is a corneal dystrophy will in many cases ultimately require corneal transplantation to maintain vision...
  24. METALLOPROTEINASE IN NORMAL AND KERATOCONUS CORNEAS
    MARIA KENNEY; Fiscal Year: 2000
    ..It has an incidence of 1 in 2,000 and is now a leading cause for corneal transplantation in the United States...
  25. REGULATION OF PHI AND FLUID FLUX IN CORNEAL ENDOTHELIUM
    Joseph Bonanno; Fiscal Year: 2001
    ..Conceivable, medical therapies can be developed to delay or supplant the need for corneal transplantation in cases of endothelial disease or trauma...
  26. CORNEAL DONOR STUDY
    Roy Beck; Fiscal Year: 2007
    Several emerging problem areas in corneal transplantation and organ donation are likely to reduce the availability of corneal donor tissues in the United States...