corneal transplantation

Summary

Summary: Partial or total replacement of the cornea from one human or animal to another.

Top Publications

  1. pmc Descemet stripping and endothelial keratoplasty in endothelial dysfunctions: three-month results in 75 eyes
    Samar K Basak
    Disha Eye Hospitals and Research Centre, Barrackpore, Kolkata, West Bengal, India
    Indian J Ophthalmol 56:291-6. 2008
  2. ncbi Corneal transplantation
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Lancet 379:1749-61. 2012
  3. ncbi Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview
    Gary S L Peh
    Singapore Eye Research Institute, Singapore
    Transplantation 91:811-9. 2011
  4. ncbi Descemet's stripping with endothelial keratoplasty in 50 eyes: a refractive neutral corneal transplant
    Francis W Price
    Price Vision Group, 9002 N Meridian St, Ste 100, Indianapolis, IN 46260, USA
    J Refract Surg 21:339-45. 2005
  5. ncbi Attenuation of ocular hypertension with the use of topical loteprednol etabonate 0.5% in steroid responders after corneal transplantation
    Edward J Holland
    Cincinnati Eye Institute, OH, USA
    Cornea 28:1139-43. 2009
  6. ncbi Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation
    Yutaka Ishino
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 45:800-6. 2004
  7. ncbi Descemet's stripping with endothelial keratoplasty in 200 eyes: Early challenges and techniques to enhance donor adherence
    Francis W Price
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 32:411-8. 2006
  8. ncbi Functional human corneal equivalents constructed from cell lines
    M Griffith
    University of Ottawa Eye Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa Hospital General Campus, Ottawa, Ontario K1H 8L6, Canada
    Science 286:2169-72. 1999
  9. ncbi Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cornea 22:273-81. 2003
  10. pmc 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival
    Sarah S Zaher
    Department of Immunology, Division of Medicine, Imperial College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:2640-8. 2011

Detail Information

Publications321 found, 100 shown here

  1. pmc Descemet stripping and endothelial keratoplasty in endothelial dysfunctions: three-month results in 75 eyes
    Samar K Basak
    Disha Eye Hospitals and Research Centre, Barrackpore, Kolkata, West Bengal, India
    Indian J Ophthalmol 56:291-6. 2008
    ..To analyze the results of Descemet stripping and endothelial keratoplasty (DSEK) in the first consecutive 75 cases...
  2. ncbi Corneal transplantation
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Lancet 379:1749-61. 2012
    b>Corneal transplantation or keratoplasty has developed rapidly in the past 10 years...
  3. ncbi Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview
    Gary S L Peh
    Singapore Eye Research Institute, Singapore
    Transplantation 91:811-9. 2011
    ..Although current corneal transplantation is more than 90% successful at 1 year, longer term results are not as encouraging with approximately 70% ..
  4. ncbi Descemet's stripping with endothelial keratoplasty in 50 eyes: a refractive neutral corneal transplant
    Francis W Price
    Price Vision Group, 9002 N Meridian St, Ste 100, Indianapolis, IN 46260, USA
    J Refract Surg 21:339-45. 2005
    To evaluate early visual and refractive outcomes following treatment of corneal endothelial dysfunction with a corneal transplantation technique, Descemet's stripping with endothelial keratoplasty (DSEK).
  5. ncbi Attenuation of ocular hypertension with the use of topical loteprednol etabonate 0.5% in steroid responders after corneal transplantation
    Edward J Holland
    Cincinnati Eye Institute, OH, USA
    Cornea 28:1139-43. 2009
    ..5% ophthalmic suspension as second-line rescue therapy after corneal transplantation.
  6. ncbi Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation
    Yutaka Ishino
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 45:800-6. 2004
    ..To achieve this, a matrix that can serve as a carrier for cHCECs is needed. The present study was conducted to examine the feasibility of using amniotic membrane (AM) as a carrier for this application...
  7. ncbi Descemet's stripping with endothelial keratoplasty in 200 eyes: Early challenges and techniques to enhance donor adherence
    Francis W Price
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 32:411-8. 2006
    ..To describe early challenges and techniques to promote donor tissue adherence in Descemet's stripping with endothelial keratoplasty (DSEK)...
  8. ncbi Functional human corneal equivalents constructed from cell lines
    M Griffith
    University of Ottawa Eye Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa Hospital General Campus, Ottawa, Ontario K1H 8L6, Canada
    Science 286:2169-72. 1999
    ..Morphological and functional equivalents to human corneas that can be produced in vitro have immediate applications in toxicity and drug efficacy testing, and form the basis for future development of implantable tissues...
  9. ncbi Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cornea 22:273-81. 2003
    ..This has changed with the recent discovery of the lymphatic endothelial markers vascular endothelial growth factor receptor 3, LYVE-1 (a lymphatic endothelium-specific hyaluronan receptor), Prox 1, and Podoplanin...
  10. pmc 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival
    Sarah S Zaher
    Department of Immunology, Division of Medicine, Imperial College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:2640-8. 2011
    ..This study was conducted to examine the effect of kynurenines, the products of tryptophan breakdown and known to act directly on T lymphocytes, on corneal graft survival...
  11. ncbi Use of autologous cultured limbal and conjunctival epithelium in a patient with severe bilateral ocular surface disease induced by acid injury: a case report of unique application
    Virender S Sangwan
    Cornea and Anterior Segment Service, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India
    Cornea 22:478-81. 2003
    ..Reconstruction of the ocular surface in a case of severe bilateral partial limbal stem cell deficiency (LSCD) with extensive symblephara using autologous cultured conjunctival and limbal epithelium...
  12. ncbi Descemet membrane endothelial keratoplasty (DMEK)
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands
    Cornea 25:987-90. 2006
    ..To describe Descemet membrane endothelial keratoplasty (DMEK) with organ cultured Descemet membrane (DM) in a human cadaver eye model and a patient with Fuchs endothelial dystrophy...
  13. ncbi Descemet stripping with automated endothelial keratoplasty for bullous keratopathies secondary to argon laser iridotomy--preliminary results and usefulness of double-glide donor insertion technique
    Akira Kobayashi
    Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cornea 27:S62-9. 2008
    ..We developed a novel nonfolding donor insertion technique using a Busin glide and an intraocular lens (IOL) sheet glide and evaluated post-DSAEK outcomes for ALI-induced BK using several insertion techniques...
  14. ncbi Endothelial cell loss after Descemet's stripping endothelial keratoplasty in a large prospective series
    Mark A Terry
    Corneal Services, Devers Eye Institute, Portland, Oregon 97210, USA
    Ophthalmology 115:488-496.e3. 2008
    ..To report the donor endothelial cell loss in the first year after Descemet's stripping endothelial keratoplasty (DSEK) for the treatment of endothelial dysfunction...
  15. ncbi Refractive change after descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter
    Bokkwan Jun
    Corneal and Refractive Surgery Services, Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Cornea 28:19-23. 2009
    ..The purpose of this study was to evaluate the refractive change after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and its correlation with graft thickness and diameter...
  16. ncbi Busin Guide vs Forceps for the Insertion of the Donor Lenticule in Descemet Stripping Automated Endothelial Keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Ophthalmol 147:220-226.e1. 2009
    ..To compare two insertion methods in Descemet stripping automated endothelial keratoplasty (DSAEK): Busin guide-assisted vs Forceps-assisted insertion of the corneal lenticule graft...
  17. pmc The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
    M Halberstadt
    Department of Ophthalmolgy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Ophthalmol 86:646-52. 2002
    ..To evaluate the outcome of corneal grafting in patients with stromal keratitis of herpetic (HSK) and non-herpetic origin, using predefined diagnostic criteria and standardised postoperative therapeutic strategies...
  18. ncbi Surgical management of scleral defects
    Altan A Ozcan
    Department of Ophthalmology, Cukurova University, Faculty of Medicine, Adana, Turkey
    Cornea 24:308-11. 2005
    ..To evaluate the results of surgical management of scleral defects using fascia lata, cornea, and sclera as graft materials...
  19. ncbi Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Ophthalmology 115:1525-33. 2008
    ....
  20. ncbi Dendritic cell physiology and function in the eye
    John V Forrester
    Section of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Immunol Rev 234:282-304. 2010
    ..This approach has considerable potential for use in translational clinical therapy to prevent sight-threatening disease caused by ocular inflammation...
  21. ncbi B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts
    Junko Hori
    Department of Ophthalmology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    J Immunol 177:5928-35. 2006
    ..B7-H1 expressed on corneal endothelial cells maintains long-term acceptance of the corneal allografts by inducing apoptosis of effector T cells within the cornea...
  22. ncbi A rabbit anterior cornea replacement derived from acellular porcine cornea matrix, epithelial cells and keratocytes
    Kunpeng Pang
    Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan, People s Republic of China
    Biomaterials 31:7257-65. 2010
    ..These results suggested that the APCM developed by using SDS might be a suitable scaffold for cornea tissue engineering...
  23. ncbi Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix
    S C Tseng
    Ocular Surface and Tear Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA
    J Cell Physiol 179:325-35. 1999
    ..It may also explain in part why fetal wound healing is scarless...
  24. ncbi Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 184:535-9. 2010
    ..Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds...
  25. pmc In vivo evaluation of a novel scaffold for artificial corneas prepared by using ultrahigh hydrostatic pressure to decellularize porcine corneas
    Shuji Sasaki
    Department of Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Vis 15:2022-8. 2009
    ..To evaluate the stability and biocompatibility of artificial corneal stroma that was prepared by using ultrahigh hydrostatic pressurization treatment to decellularize corneas...
  26. ncbi Descemet-stripping automated endothelial keratoplasty
    Mark S Gorovoy
    Cornea 25:886-9. 2006
    ..To evaluate the speed of visual recovery in 16 consecutive patients with corneal endothelial dysfunction who received Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  27. ncbi A surgical technique for posterior lamellar keratoplasty
    G R Melles
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Cornea 17:618-26. 1998
    ..To design a surgical technique for transplantation of posterior corneal tissue, while leaving the recipient anterior cornea intact...
  28. ncbi The resiliency of the corneal endothelium to refractive and intraocular surgery
    H F Edelhauser
    Department of Ophthalmology, Emory Eye Center, Atlanta, Georgia 30322, USA
    Cornea 19:263-73. 2000
    ....
  29. ncbi Endothelial keratoplasty: historical perspectives, current techniques, future directions
    Linda Rose
    Cornea and External Diseases, University of New Mexico, Albuquerque, NM, USA
    Can J Ophthalmol 44:401-5. 2009
    ..In this review we discuss the history of EK, recent advances that have led to its widespread use, limits and complications of the procedure, and areas for future improvement...
  30. ncbi Modified air-assisted descemetorhexis for Descemet-stripping automated endothelial keratoplasty
    Jodhbir S Mehta
    Singapore National Eye Centre, Singapore
    J Cataract Refract Surg 34:889-91. 2008
    ....
  31. ncbi Corneal profile analysis after Descemet stripping endothelial keratoplasty and its relationship to postoperative hyperopic shift
    Huck A Holz
    John A Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    J Cataract Refract Surg 34:211-4. 2008
    ....
  32. ncbi Descemet's stripping endothelial keratoplasty
    Marianne O Price
    Cornea Research Foundation of America, Indianapolis, IN, USA
    Curr Opin Ophthalmol 18:290-4. 2007
    ..Familiarity with recent advances in techniques and instrumentation can help reduce the initially steep learning curve and incidence of complications...
  33. ncbi Comparison of the pig and feline models for full thickness corneal transplantation
    Isabelle Brunette
    Maisonneuve Rosemont Hospital Research Center, Montreal, QC, Canada
    Vet Ophthalmol 14:365-77. 2011
    The goal of this study was to report on the advantages and limitations of the pig and feline models for experimental in vivo corneal transplantation.
  34. ncbi Effect of administration of CTLA4-Ig as protein or cDNA on corneal allograft survival
    Richard M Comer
    Department of Immunology, Division of Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 43:1095-103. 2002
    ..To examine the role of the CD28-CD80-CD86 pathway of T-lymphocyte costimulation in corneal allograft rejection and the effect of blockade of that pathway on graft survival...
  35. ncbi Descemet-stripping automated endothelial keratoplasty by using suture for donor insertion
    Vincenzo Sarnicola
    Misericordia Hospital, Grosseto, Italy
    Cornea 27:825-9. 2008
    ..To describe a new technique for donor insertion in cases of Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  36. ncbi Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
    Lu Chen
    Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
    Nat Med 10:813-5. 2004
    ..Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery...
  37. ncbi Deep anterior lamellar keratoplasty using an original manual technique
    Paolo Rama
    Ospedale San Raffaele, Unità Cornea e Superficie Oculare, Via Olgettina 60, Milano 20132, Italy
    Br J Ophthalmol 97:23-7. 2013
    ..To evaluate the clinical findings and visual outcomes of deep anterior lamellar keratoplasty (DALK) using an original manual dissection technique...
  38. ncbi Comparative study of stromal bed quality by using mechanical, IntraLase femtosecond laser 15- and 30-kHz microkeratomes
    Melvin A Sarayba
    IntraLase Corp, Irvine, CA, USA
    Cornea 26:446-51. 2007
    ..To evaluate corneal stromal bed quality of lamellar keratectomy in laser in situ keratomileusis (LASIK) procedures by using mechanical and femtosecond laser microkeratomes...
  39. ncbi Alternatives to allograft corneal transplantation
    Vishal Jhanji
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Curr Opin Ophthalmol 21:301-9. 2010
    b>Corneal transplantation is the most commonly performed solid organ transplantation in the world...
  40. ncbi TNF receptor secretion after ex vivo adenoviral gene transfer to cornea and effect on in vivo graft survival
    S A Rayner
    Department of Immunology, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Invest Ophthalmol Vis Sci 42:1568-73. 2001
    ..However, in vivo, only a marginally increased survival was seen compared with control corneas. The introduction of this transgene using a less immunogenic vector may demonstrate prolongation of corneal allograft survival...
  41. ncbi Suture technique for Descemet stripping and endothelial keratoplasty
    Marian Sue Macsai
    Division of Ophthalmology, Evanston Northwestern Healthcare, Evanston, IL, USA
    Cornea 26:1123-6. 2007
    ..To describe a suture technique for Descemet stripping and endothelial keratoplasty (DSEK)...
  42. pmc Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation
    Fengfu Li
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada K1H 8L6
    Proc Natl Acad Sci U S A 100:15346-51. 2003
    ..These biosynthetic ECM replacements should have applicability to many areas of tissue engineering and regenerative medicine, especially where nerve function is required...
  43. pmc In vivo confocal microscopy of the corneal endothelium: comparison of three morphometry methods after corneal transplantation
    S Jonuscheit
    Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK
    Eye (Lond) 25:1130-7. 2011
    ..The purpose of this study was to assess the endothelium of corneal grafts by in vivo confocal microscopy (IVCM), and to evaluate an automated endothelial software system in comparison with a manual cell count and planimetry...
  44. pmc CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival
    P M Stuart
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 99:396-402. 1997
    ..immune privilege has been implicated in the success of these transplants, we examined the role of FasL in corneal transplantation. Our results show that human corneas express functional FasL capable of killing Fas+ lymphoid cells in an ..
  45. ncbi Comparison of deep lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus
    Stephanie L Watson
    Corneal and External Diseases, Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 111:1676-82. 2004
    ..To compare the therapeutic outcomes after deep lamellar keratoplasty (DLK) and penetrating keratoplasty (PK) in patients with keratoconus...
  46. ncbi Femtosecond-laser-assisted Descemet's stripping endothelial keratoplasty
    Yanny Y Y Cheng
    Department of Ophthalmology, University Hospital Maastricht, Maastricht, The Netherlands
    J Cataract Refract Surg 33:152-5. 2007
    ..1 diopters, demonstrating a functional corneal endothelial layer. The femtosecond laser offers a new surgical approach for minimally invasive endothelial keratoplasty in corneal endothelial disorders...
  47. ncbi Corneal allograft rejection: current understanding. 2. Clinical implications
    Eckart Bertelmann
    Department of Ophthalmology, Charite, Humboldt University, Berlin, Germany
    Ophthalmologica 216:2-12. 2002
  48. ncbi One donor cornea for 3 recipients: a new concept for corneal transplantation surgery
    Rasik B Vajpayee
    Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Arch Ophthalmol 125:552-4. 2007
    ..To describe the use of a single donor corneal tissue in 3 patients with corneal pathologic conditions...
  49. ncbi Risk factors, clinical features, and outcomes of recurrent fungal keratitis after corneal transplantation
    Weiyun Shi
    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Ophthalmology 117:890-6. 2010
    To study the risk factors, clinical features, and treatment of recurrent fungal keratitis after corneal transplantation.
  50. pmc FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations
    K Mayer
    Eye Hospital, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Br J Ophthalmol 88:915-9. 2004
    ..The authors investigated the potency of FTY720 in inhibiting allograft rejection in the rat model of orthotopic allogeneic penetrating keratoplasty...
  51. ncbi Paradigm shifts in corneal transplantation
    Donald T H Tan
    Singapore National Eye Centre, Singapore
    Ann Acad Med Singapore 38:332-8. 2009
    Conventional corneal transplantation, in the form of penetrating keratoplasty (PK), involves full-thickness replacement of the cornea, and is a highly successful procedure. However, the cornea is anatomically a multi-layered structure...
  52. ncbi The use of postoperative slit-lamp optical coherence tomography to predict primary failure in descemet stripping automated endothelial keratoplasty
    Carolyn Y Shih
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, New York, USA
    Am J Ophthalmol 147:796-800, 800.e1. 2009
    ....
  53. ncbi Descemet membrane automated endothelial keratoplasty: hybrid technique combining DSAEK stability with DMEK visual results
    Matthew B McCauley
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 35:1659-64. 2009
    ..The Descemet membrane automated endothelial keratoplasty transplantation technique combines the superior vision potential of Descemet membrane endothelial keratoplasty with the easier insertion and manipulation of DSAEK...
  54. ncbi Development and characterization of a full-thickness acellular porcine cornea matrix for tissue engineering
    Liqun Du
    Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China
    Artif Organs 35:691-705. 2011
    ..The matrix is biocompatible with cornea-derived cells and has potential for use in corneal transplantation and tissue-engineering applications.
  55. pmc Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation
    Takaaki Hattori
    Schepens Eye Research Institute, Boston, MA 02114, USA
    J Leukoc Biol 91:621-7. 2012
    ..We therefore used the murine model of corneal transplantation to address this, as these allografts are rejected in an indirect pathway-dominant manner...
  56. ncbi SEB combined with IL-1ra could prolong the survival of the rat allografts in high-risk corneal transplantation
    Y Jie
    Beijing Institute of Ophthalmology and the Tongren Eye Bank, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Transplant Proc 36:3267-71. 2004
    To determine whether the superantigen Staphylococcal enterotoxin B (SEB) combined with interleukin-1 receptor antagonist (IL-1ra) prolong allograft survival better than individual agents in high-risk corneal transplantation in a rat model.
  57. pmc Arginine depletion as a mechanism for the immune privilege of corneal allografts
    Hongmei Fu
    Section of Immunobiology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Eur J Immunol 41:2997-3005. 2011
    ..These data show that arginase is functional in the cornea and contributes to the immune privilege of the eye, and that modulation of arginase contributes to graft survival...
  58. pmc Differential roles of direct and indirect allorecognition pathways in the rejection of skin and corneal transplants
    Florence Boisgerault
    Department of Surgery, Transplantation Unit, Cellular and Molecular Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transplantation 87:16-23. 2009
    ..It is generally accepted that all transplants are not rejected in the same fashion. However, the extrinsic and intrinsic factors that control the recognition and rejection of a particular allograft by the host are not well characterized...
  59. ncbi Patient satisfaction after corneal transplantation
    E Uiters
    Department of Health Education, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Cornea 20:687-94. 2001
    To determine the relationship between objective and subjective outcome measures and patient satisfaction after corneal transplantation.
  60. ncbi Immune privilege and angiogenic privilege of the cornea
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Chem Immunol Allergy 92:50-7. 2007
    ..an immune-privileged site and tissue, enabling the extraordinary success of histologically incompatible corneal transplantation. Recent evidence indicates that there is considerable overlap in the molecular mechanisms maintaining ..
  61. ncbi Deep anterior lamellar keratoplasty combined with autologous limbal stem cell transplantation in unilateral severe chemical injury
    Rajesh Fogla
    Sankara Nethralaya, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India
    Cornea 24:421-5. 2005
    ....
  62. ncbi Corneal graft rejection
    Anita Panda
    Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Surv Ophthalmol 52:375-96. 2007
    ..New systemic pharmacological interventions recommended in corneal transplantation need further evaluation and detailed guidelines...
  63. ncbi Transplantation of Descemet's membrane carrying viable endothelium through a small scleral incision
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands
    Cornea 21:415-8. 2002
    ..To design a technique for transplantation of the Descemet's membrane (DM) as a carrier for its endothelium, while maintaining the low-astigmatic recipient anterior corneal curvature...
  64. ncbi Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation
    Jun Shimazaki
    The Department of Ophthalmology, Tokyo Dental College, 5 11 13 Sugano, Ichikawa shi, Chiba 272 8513, Japan
    Transplantation 78:216-20. 2004
    ..This single-center, case-controlled study was conducted to show the efficacy and safety of corneal transplantation using corneas from foreign donors.
  65. ncbi The immune response to corneal allograft requires a site-specific draining lymph node
    Jarmila Plsková
    Department of Ophthalmology, University of Aberdeen, Medical School Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Transplantation 73:210-5. 2002
    ..In this study we have investigated further the role of the DLN and spleen in corneal graft rejection in mice...
  66. ncbi Graft failure IV. Immunologic mechanisms of corneal transplant rejection
    Eva Marie Chong
    Cornea Service, Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Int Ophthalmol 28:209-22. 2008
    b>Corneal transplantation is the oldest and the most common form of solid tissue transplantation in humans. Immunologic graft rejection is one of the main causes of short and long-term graft failure...
  67. ncbi Corneal graft surgery combined with subconjunctival bevacizumab (avastin)
    Richard J Symes
    Department of Ophthalmology, Frimley Park Hospital, Camberley, Surrey, United Kingdom
    Cornea 29:691-3. 2010
    ..To describe the use of subconjunctival bevacizumab (Avastin) as an adjunctive treatment in a vascularized cornea at the time of lamellar keratoplasty to reduce the risk of graft rejection...
  68. ncbi Deep anterior lamellar keratoplasty
    Shigeto Shimmura
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Curr Opin Ophthalmol 17:349-55. 2006
    ..This review focuses on recent advances in deep anterior lamellar keratoplasty...
  69. ncbi Comparison of three different techniques of corneal transplantation for keratoconus
    Irit Bahar
    Ophthalmology Department, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Am J Ophthalmol 146:905-12.e1. 2008
    To compare the visual outcomes following deep anterior lamellar keratoplasty (DALK), penetrating keratoplasty (PK), and manual top-hat PK (TH-PK) in subjects undergoing corneal transplantation for keratoconus (KC).
  70. ncbi Oligopotent stem cells are distributed throughout the mammalian ocular surface
    Francois Majo
    Laboratory of Stem Cell Dynamics, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne CH, Switzerland
    Nature 456:250-4. 2008
    ..We propose a model that unifies our observations with the literature and explains why the limbal region is enriched in stem cells...
  71. ncbi Preliminary clinical results of Descemet membrane endothelial keratoplasty
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Laan Op Zuid 390, Rotterdam, The Netherlands
    Am J Ophthalmol 145:222-227. 2008
    ..5-mm incision, tentatively named Descemet membrane endothelial keratoplasty (DMEK), for the management of corneal endothelial disorders...
  72. ncbi Effect of donor age on morphologic variation of cultured human corneal endothelial cells
    K Miyata
    Miyata Eye Hospital, Miyakonojo, Japan
    Cornea 20:59-63. 2001
    ..935, p = 0.0007). CONCLUSION: Cultured HCEC established from older donor tissue display greater heterogeneity. The use of HCEC from younger donors may be preferable to maximize the benefits of HCEC transplantation...
  73. ncbi Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering
    Yoshihide Hashimoto
    Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
    Biomaterials 31:3941-8. 2010
    ..The decellularized corneas obtained through HHP could be useful as a corneal scaffold for tissue regeneration...
  74. ncbi The impact of corneal allograft rejection on the long-term outcome of corneal transplantation
    Douglas J Coster
    Department of Ophthalmology, Flinders University, Bedford Park, Adelaide, SA 5042, Australia
    Am J Ophthalmol 140:1112-22. 2005
    To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for alternative ..
  75. ncbi Risk factors for human corneal graft failure within the Australian corneal graft registry
    Keryn A Williams
    Department of Ophthalmology, Flinders University of South Australia, Adelaide, South Australia, Australia
    Transplantation 86:1720-4. 2008
    Our aims were to examine graft survival and visual outcome after full-thickness corneal transplantation.
  76. ncbi The Boston type I keratoprosthesis: improving outcomes and expanding indications
    Anthony J Aldave
    Cornea Service, The Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Ophthalmology 116:640-51. 2009
    ..To report the usefulness of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal opacification, corneal limbal stem cell failure, or both in a large single-surgeon series...
  77. ncbi Comparison of outcomes of lamellar keratoplasty and penetrating keratoplasty in keratoconus
    Daphne C Y Han
    Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 148:744-751.e1. 2009
    ..To compare outcomes after penetrating keratoplasty (PK) and two techniques of deep anterior lamellar keratoplasty (DALK) in patients with keratoconus...
  78. ncbi Human fibrin tissue adhesive for sutureless lamellar keratoplasty and scleral patch adhesion: a pilot study
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Ophthalmology 110:2168-72. 2003
    ..To determine whether a fibrin adhesive can facilitate the performance of sutureless lamellar keratoplasty and attachment of amnion to bare sclera...
  79. ncbi Corneal transplant tolerance of cryopreservation
    I Brunette
    Department of Ophthalmology, University of Montreal, Montreal, Canada
    Cornea 20:590-6. 2001
    ..Although we do not recommend cryopreservation of corneas for elective surgery, we consider that cryopreserved corneas can be very useful in emergency situations when tissue availability is a problem...
  80. ncbi Results of deep lamellar keratoplasty using the big-bubble technique in patients with keratoconus
    Rajesh Fogla
    Cornea Services, Sankara Nethralaya, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India
    Am J Ophthalmol 141:254-259. 2006
    ..To evaluate the efficacy of deep lamellar keratoplasty using the big-bubble technique in patients with keratoconus...
  81. ncbi MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice
    Jun Yamada
    Department of Ophthalmology, Meiji University of Integrative Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 50:2139-46. 2009
    ..The present study was designed to determine the role of IFN-gamma and IL-17 in the rejection by C57BL/6 hosts, which display high rejection rates...
  82. ncbi Descemet stripping endothelial keratoplasty: effect of the surgical procedure on corneal optics
    Srinivas K Rao
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, People s Republic of China
    Am J Ophthalmol 145:991-6. 2008
    To determine the changes in corneal optical performance after posterior lamellar corneal transplantation.
  83. ncbi Immune modulation in corneal transplantation
    Hongmei Fu
    Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Transplant Rev (Orlando) 22:105-15. 2008
    ..prevent corneal allograft rejection, various immunomodulatory strategies have been used in experimental corneal transplantation. These include (1) anti-T-cell receptor and T-cell depletion therapy; (2) manipulation of costimulatory ..
  84. ncbi Retrospective contralateral study comparing descemet stripping automated endothelial keratoplasty with penetrating keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, Ontario, Canada
    Cornea 28:485-8. 2009
    ....
  85. ncbi Clinical outcomes after deep anterior lamellar keratoplasty using the big-bubble technique in patients with keratoconus
    Luigi Fontana
    Unità Operativa di Oculistica, Ospedale Maggiore, Largo Nigrisoli 2, 40133 Bologna, Italy
    Am J Ophthalmol 143:117-124. 2007
    ..To report clinical outcomes of deep anterior lamellar keratoplasty (DALK) using the big-bubble technique in patients with keratoconus...
  86. ncbi Cataract progression and treatment following posterior lamellar keratoplasty
    Marianne O Price
    Cornea Research Foundation of America, Indianapolis, IN, USA
    J Cataract Refract Surg 30:1310-5. 2004
    ..To describe the development and treatment of cataracts following posterior lamellar keratoplasty (PLK) in phakic eyes with Fuchs' endothelial dystrophy...
  87. ncbi Candida interface keratitis after deep anterior lamellar keratoplasty: clinical, microbiologic, histopathologic, and confocal microscopic reports
    Mozhgan Rezaei Kanavi
    Labbafinejad Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran
    Cornea 26:913-6. 2007
    ..To report the clinical, histopathologic, microbiologic, and confocal microscopic features of Candida keratitis after deep anterior lamellar keratoplasty (DALK)...
  88. ncbi Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice
    Lucia Kuffova
    Department of Ophthalmology, Institute of Molecular Sciences, Medical School Foresterhill, University of Aberdeen, Aberdeen, Scotland
    J Immunol 180:1353-61. 2008
    ..Ag trafficking from the cornea and T effector cell activation in secondary lymphoid tissue after corneal transplantation. In preliminary experiments, the central cornea was shown to contain a population of CD45(+), CD11b(+), ..
  89. pmc IL-17 promotes immune privilege of corneal allografts
    Khrishen Cunnusamy
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 185:4651-8. 2010
    ..These findings demonstrate that IL-17A is not required for corneal allograft rejection and may instead contribute to the immune privilege of corneal allografts...
  90. ncbi Tissue engineering of the cornea
    Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Cornea 22:S28-34. 2003
    ..of the cornea represents a paradigm shift in medical treatment to overcome the present disadvantages of corneal transplantation, primarily immune rejection and the shortage of donor corneas...
  91. ncbi Aqueous humor alloreactive cell phenotypes, cytokines and chemokines in corneal allograft rejection
    T H Flynn
    Department of Ocular Immunology, UCL Institute of Ophthalmology, London, UK
    Am J Transplant 8:1537-43. 2008
    ..Aqueous humor samples offer a unique opportunity to analyze components of the allogeneic response in direct contact with donor tissue but without artifacts inherent in examination of tissue...
  92. ncbi Epidemiology and risk factors for corneal graft rejection
    D Sellami
    Department of Ophthalmology, CHU Habib Bourguiba, 3029 Sfax, Tunisia
    Transplant Proc 39:2609-11. 2007
    ..The aim of this study was to evaluate the frequency and main risk factors for corneal graft rejection...
  93. ncbi [Evaluation of the quality of a donor cornea before transplantation]
    M Cernák
    Ocná klinika SPAM, Bratislava
    Cesk Slov Oftalmol 58:319, 323-5. 2002
    ..The quality of the donor cornea determines in a major way the success of transplantation and therefore the demands on its quality must be high...
  94. pmc Two different regulatory T cell populations that promote corneal allograft survival
    Khrishen Cunnusamy
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Invest Ophthalmol Vis Sci 51:6566-74. 2010
    ..To compare and contrast the T regulatory cells (Tregs) induced by anterior chamber (AC) injection of antigen with those induced by orthotopic corneal allografts...
  95. ncbi Histopathological study of delayed regraft after corneal graft failure
    Leonardo N Santos
    Department of Ophthalmology and Pathology, The McGill University Health Center and Henry C Witelson Ocular Pathology Laboratory, Montreal, Canada
    Cornea 30:167-70. 2011
    ..To evaluate the histopathological features of corneal graft failures over time...
  96. ncbi Primary graft failure after Descemet-stripping automated endothelial keratoplasty: clinico-pathological study
    Jodhbir Singh Mehta
    Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore
    Cornea 27:722-6. 2008
    Descemet-stripping automated endothelial keratoplasty (DSAEK) is a selective tissue corneal transplantation procedure in which only the diseased endothelium and the Descemet membrane is replaced...
  97. pmc Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation
    Sunil K Chauhan
    Schepens Eye Research Institute, Boston, MA 02114, USA
    J Immunol 182:148-53. 2009
    ..Thus, we investigated the kinetics and function of Tregs in a mouse model of orthotopic corneal transplantation, the most common form of tissue grafting worldwide...
  98. ncbi The taming of the shrew? The immunology of corneal transplantation
    Uwe Pleyer
    Department of Ophthalmology, Charite University Berlin, Germany
    Acta Ophthalmol 87:488-97. 2009
    b>Corneal transplantation, first reported a century ago, is the oldest and most frequent form of solid tissue transplantation...
  99. ncbi Descemet-stripping automated endothelial keratoplasty: six-month results in a prospective study of 100 eyes
    Edwin S Chen
    Devers Eye Institute, Portland, OR 97210, USA
    Cornea 27:514-20. 2008
    ..To report 6-month results in a large, prospective study of Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  100. ncbi Descemetic DALK and predescemetic DALK: outcomes in 236 cases of keratoconus
    Vincenzo Sarnicola
    Department of Ophthalmology, Misericordia Hospital, Grosseto, Italy
    Cornea 29:53-9. 2010
    ..To report the outcomes of our experience with deep anterior lamellar keratoplasty (DALK) in patients with keratoconus...
  101. ncbi Effect of cytokine-induced migration of Langerhans cells on corneal allograft survival
    J Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235 9057, USA
    Eye (Lond) 9:215-8. 1995
    ..Although the presence of donor-specific LCs greatly jeopardises corneal allograft survival, migration of host-derived LCs into corneal allografts does not appear to increase the risk of rejection...

Research Grants63

  1. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..applicant): Bioengineered corneal endothelium is being explored as an exciting, practical alternative to corneal transplantation to treat vision loss due to endothelial injury or disease...
  2. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2012
    ..g., LASEK, PRK, corneal transplantation, and Dry Eye...
  3. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2013
    ..application to further characterize the molecular and cellular facets of host immunity in high-risk corneal transplantation. High-risk corneal grafts are characterized by their rapid and high frequency of rejection...
  4. The Role of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal Dys
    Ula V Jurkunas; Fiscal Year: 2013
    ..b>Corneal transplantation is the only currently available measure to restore lost vision...
  5. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2011
    ..b>Corneal transplantation is often needed to restore corneal clarity...
  6. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    ..remains the major cause of infectious blinding disease in the US, with the only effective treatment being corneal transplantation. HSK is triggered by reactivation of herpes simplex virus type 1 (HSV-1) from a latent state that is ..
  7. Corneal Lymphatics &Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2013
    ..to HSV-1 infection operates thru a unique pathway distinct from what has been described following corneal transplantation. Specifically, we have found a robust vascular endothelial growth factor (VEGF) A response by corneal ..
  8. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    ..and anti-inflammatory therapies fail in approximately 30% of patients, resulting in the need for corneal transplantation. Development of new drugs with different mechanisms of action is critical...
  9. Genomic systems approach to measure HSV-1-specific T-cell dominance in humans
    David M Koelle; Fiscal Year: 2013
    ..adults or neonates, and corneal inflammation leading to blindness and poor long- term outcomes even after corneal transplantation, occur at a low per-person rate...
  10. Corneal Stromal-Epithelial Interactions During Fibrosis and Regeneration
    James D Zieske; Fiscal Year: 2012
    ..Currently, no therapies are available except for corneal transplantation. Our studies will also evaluate if manipulating [unreadable]v[unreadable]6 or if treating wounds with T3 ..
  11. Engineering of Human Corneal Endothelial Grafts
    Ying Ting Zhu; Fiscal Year: 2012
    ..from stripped Descemet membrane of 1/8 of the corneoscleral rim normally discarded after conventional corneal transplantation. Thus, in this Phase I application, we would like to prove the concept that the size of HCEC monolayers ..
  12. Corneal endothelial cell survival in human donor corneas for transplantation
    Shay Whey M Koh; Fiscal Year: 2012
    ..applying this knowledge gained from studying CE cell physiology to the enhancement of CE cell survival in corneal transplantation, which is our goal, we will also validate the relevance of this knowledge...
  13. Zebrafish Model of Human Corneal Development and Disease
    Martin Heur; Fiscal Year: 2013
    ..pax6b mutations feature corneal edema secondary to corneal endothelial dysfunction, frequently requiring corneal transplantation. The third aim will explore the developmental role of vsx1 and pax6b in corneal endothelial development...
  14. THE IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Corneal transplantation is the oldest, most common, and arguably, the most successful form of solid tissue grafting. In the U.S. alone, over 40,000 corneal transplants are performed each year...
  15. The role of PPAR{gamma} ligands in corneal wound healing and optics
    Krystel R Huxlin; Fiscal Year: 2013
    ..disruption to normal corneal structure and function, whether from infection, laser refractive surgery, corneal transplantation, ocular trauma (chemical or physical) or corneal dystrophies...
  16. Robo-Slit Signaling in Avian Cornea Innervation
    Tyler Schwend; Fiscal Year: 2013
    ....
  17. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2013
    ..Additionally, corneal transplantation offers an excellent model for lymphatic research because it allows for (i) functional lymphatic cell ..
  18. Composite Allografting for Promoting Survival of Corneal Transplants
    DANIEL RAPHAEL SABAN; Fiscal Year: 2010
    ..LAY DESCRIPTION: Success rates for corneal transplantation are very poor in eyes with severe inflammation (so-called 'high-risk'hosts)...
  19. Pre-mRNA Interference of VEGF Pathways in Ocular Angiogenesis
    Balamurali K Ambati; Fiscal Year: 2013
    ..This could translate into improved outcomes for veterans who sustain eye injury and require corneal transplantation (as fighting blood vessel formation is essential to corneal transparency and preventing corneal ..
  20. Training Program in the Molecular Bases of Eye Diseases
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    ..degeneration, glaucoma, retinopathy of prematurity, corneal inflammation, wound healing, dry eye and corneal transplantation, among many others. This diversity provides a wide range of training opportunities...
  21. Early Detection of Keratoconus
    Ronald H Silverman; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Keratoconus (KC) is a corneal dystrophy will in many cases ultimately require corneal transplantation to maintain vision...
  22. The Pathogenesis of Aspergillus Keratitis
    SIXTO MANUEL LEAL; Fiscal Year: 2012
    ..During Aspergillus keratitis, the inflammation can be so severe that 42-60% of infections end with corneal transplantation. Before such bleak clinical outcomes improve, we must invest in research to better understand the ..
  23. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ..ocular-thymic link confirms an active role for the thymus and the eye in the regulation of systemic immunity that could impact on the management of inflammatory eye disease, corneal transplantation, ocular tumors and autoimmune disease.
  24. THE ROLE OF APOPTOTIC MOLECULES IN HERPETIC STROMAL
    Patrick M Stuart; Fiscal Year: 2010
    Our laboratory has been studying the role that Fas and Fas ligand play in corneal transplantation and have published several manuscripts detailing the importance of this interaction to the success of corneal allografts and the ..
  25. Integrative Genetic Analyses in Fuchs Endothelial Corneal Dystrophy
    Sudha K Iyengar; Fiscal Year: 2013
    ..Although medical management of symptoms may be attempted, most patients ultimately require corneal transplantation. As a result, FECD is a leading indication for corneal transplantation in the U.S...
  26. Noninvasive 3D Microscopic Studies of Corneal Elasticity and Collagen Structure
    Tibor Juhasz; Fiscal Year: 2011
    ..biomechanics, such as keratoconus and post-LASIK ectasia affect millions of people and often necessitate corneal transplantation. Corneal biomechanics also plays an increasingly recognized role in the post-operative results of ..
  27. Intraoperative Optical Coherence Tomography for Ophthalmic Surgery
    Justis Ehlers; Fiscal Year: 2013
    ..g., cataract surgery, corneal transplantation, macular hole surgery, epiretinal membrane surgery)...
  28. Corneal Endothelial Cell Transplantation
    Sanjay V Patel; Fiscal Year: 2010
    ..by applicant): Corneal endothelial cell dysfunction causes decreased vision and can only be treated by corneal transplantation to replace human corneal endothelial cells (HCECs), which do not proliferate in vivo...
  29. Nanoscale presentation of antimicrobial peptides found at the ocular surface
    Chengzhi Cai; Fiscal Year: 2010
    ..that often leads to permanently compromised visual function, sometimes to an extent that necessitates corneal transplantation to restore adequate vision...
  30. Cloning/Gene/Posterior Polymorphous corneal dystrophy
    ANTHONY ALDAVE; Fiscal Year: 2009
    ..controlled proliferation of corneal endothelial cells in vivo or in vitro, providing an alternative to corneal transplantation for patients with an insufficient number of corneal endothelial cells to maintain corneal clarity, one of ..
  31. Transplantation of a self-assembled corneal substitute
    James D Zieske; Fiscal Year: 2013
    ..Only a small fraction of these patients will be treated by corneal transplantation. Scar is a condition characterized by the presence of myofibroblasts and the excessive and improper ..
  32. Corneal Epithelial Growth Factors and Receptors
    STEVEN EUGENE WILSON; Fiscal Year: 2013
    ..It may also lead to treatments to increase scaring in the cornea where it is beneficial, for example at the donor-recipient junction in corneal transplantation.
  33. Tissue Engineering Cornea Replacements
    David L Kaplan; Fiscal Year: 2013
    ..degrades to allow for host native tissue replacement would offer a significant and novel advancement in corneal transplantation technology...
  34. Genetics and Genomics of Fuchs Endothelial Corneal Dystrophy
    VENKATESWARA VINOD MOOTHA; Fiscal Year: 2013
    ..FECD is the leading indication for corneal transplantation in the country...
  35. Immunobiology of Corneal Antigen-Presenting Cells
    Pedram Hamrah; Fiscal Year: 2013
    ..3) examine the spatial, temporal and behavioral characteristics of donor and host APC after corneal transplantation and their interaction with T cells in lymph nodes...
  36. Corneal Elastography and Patient-Specific Modeling for Simulation-based Therapy
    WILLIAM JOSEPH DUPPS; Fiscal Year: 2013
    ..major cause of impaired vision-related quality of life in the United States and a leading indication for corneal transplantation. The lack of clinical tools for resolving biomechanical properties throughout the cornea is a critical ..
  37. Small Incision Artificial Cornea
    YICHIEH SHIUEY; Fiscal Year: 2013
    ..The use of the KeraKlear artificial cornea also avoids the common complications of corneal transplantation including high astigmatism, corneal graft failure and corneal graft rejection...
  38. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..It is a leading indication for corneal transplantation within the United States...
  39. Imaging to predict refractive outcomes after corneal endothelial keratoplasty
    Anthony Nanlin Kuo; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This project will develop new methods to study and improve corneal transplantation. Knowledge gained from this project may help to customize grafts optically for individual patients.
  40. Novel Treatment for Post-LASIK Ectasia
    MATTHEW MATTSON; Fiscal Year: 2009
    ..in progressive steepening and thinning of the cornea that can lead to severe visual loss and require corneal transplantation. This project will result in an innovative light-activated treatment that will arrest post-LASIK ectasia ..
  41. Device for Facilitating Corneal Transplantation
    YICHIEH SHIUEY; Fiscal Year: 2006
    ..Although corneal transplantation surgery is generally considered to be successful, the most common technique, penetrating keratoplasty (PK)..
  42. COMPUTER SYSTEM FOR PATIENT DATA-BASE MANAGEMENT
    Andrew Schachat; Fiscal Year: 1990
    ..History and Genetic Studies, have evolved in Wilmer bearing on such eye problems as ocular melanoma, corneal transplantation, glaucoma, optic neuritis, juvenile diabetes, intraocular lens implantation, retinitis pigmentosa, the ..
  43. IN VIVO ANALYSIS OF CORNEAL ENDOTHELIAL WOUND HEALING
    W Petroll; Fiscal Year: 1991
    ..keratopathy following previous cataract-IOL surgery constitutes the largest single indication for human corneal transplantation. A better understanding of the endothelial wound healing process in vivo would clearly be valuable in ..
  44. GENES FOR KERATOCONUS AND OCULAR FEATURES IN TRISOMY 21
    Katherine Bergwerk; Fiscal Year: 2002
    ..This will obviate the need for the current therapy of multiple complex contact lens fittings or corneal transplantation surgery...
  45. COLLABORATIVE CORNEAL TRANSPLANTATION STUDIES
    Gary Foulks; Fiscal Year: 1991
    The proposed Collaborative Corneal Transplantation Studies (CCTS) consist of two multicenter studeis of the effectiveness of histocompatibility testing in preventing corneal allograft rejection in high risk patients...
  46. A robotic device to faciliate corneal transplantation and other corneal surgeries
    YICHIEH SHIUEY; Fiscal Year: 2010
    ..By providing a uniform pocket in a live or donor cornea, corneal transplantation may be performed more safely, quickly, and with better visual outcomes...
  47. MOLECULAR GENETIC STUDIES IN CORNEAL DYSTROPHIES
    Richard Yee; Fiscal Year: 2000
    ..of RBCD may shed light on the more common problem of corneal scarring, the most common cause for corneal transplantation in the American elderly...
  48. Inhibition of corneal graft rejection by antioxidants
    Georges Tocco; Fiscal Year: 2003
    b>Corneal transplantation is the most common form of tissue allotransplantation (47,000 cases per year). However, 15% of the grafts are rejected within a year in "high risk" patients...
  49. Role of Corneal Lymphangiogenesis in Alloimmunity
    Lu Chen; Fiscal Year: 2005
    ..More importantly, APC trafficking to the draining lymph nodes (LN) after corneal transplantation, a critical component of inducing immunity to corneal grafts, is greatly reduced by an anti-VEGFR-3 ..
  50. STUDIES OF THE CORNEA
    William Bourne; Fiscal Year: 2007
    ..S., corneal transplantation and excimer laser refractive surgery, the former to restore useful vision to abnormal corneas and the ..
  51. CORNEAL TRANSPLANTATION STUDIES
    Maureen Maguire; Fiscal Year: 1992
    The proposed Collaborative Corneal Transplantation Studies (CCTS) consist of two multicenter studies of the effectiveness of histocompatibility matching in preventing corneal allograft rejection in high risk eyes...
  52. COLLABORATIVE CORNEAL TRANSPLANTATION STUDIES
    R Stulting; Fiscal Year: 1991
    The proposed Collaborative Corneal Transplantation Studies (CCTS) consist of two multicenter studies of the effectiveness of histocompatibility matching in preventing corneal allograft rejection in high risk eyes...
  53. Mapping and cloning genes for Keratoconus
    Bassem Bejjani; Fiscal Year: 2007
    ..Although KC is an uncommon condition, it is the single most common cause for corneal transplantation in North America and thus carries substantial morbidity and expense...
  54. LASER WELDING OF OCULAR TISSUES
    WILLIAM JEFFERS; Fiscal Year: 1993
    ..of laser tissue welding as an adjunct to homogeneous wound healing, and reduce residual astigmatism in corneal transplantation. Corneal welding may further assist in securing epikeratophakia lenticules and other corneal procedures ..
  55. IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATION
    JOHN KRIESEL; Fiscal Year: 2002
    ..Acute and recurrent herpes simplex keratitis are leading indications for corneal transplantation in this country...
  56. New Biomaterials for Cornea Replacement
    David Kaplan; Fiscal Year: 2009
    ..that slowly degrades to allow for host native tissue replacement would offer a significant advancement in corneal transplantation technology...
  57. COLLABORATIVE CORNEAL TRANSPLANTATION STUDIES
    ROGER MEYER; Fiscal Year: 1991
    The proposed Collaborative Corneal Transplantation Studies (CCTS) consist of two multicenter studies of the effectiveness of histocompatibility matching in preventing corneal allograft rejection in high risk eyes...
  58. Pathobiology of Corneal Disease
    Pamela Farthing Nayak; Fiscal Year: 2005
    ..severe nearsightedness, irregular astigmatism and scarring in the visual axes, is a leading cause of corneal transplantation in the US...
  59. MOLECULAR STUDIES OF THE THIEL-BEHNKE CORNEAL DYSTROPHY
    Richard Yee; Fiscal Year: 2006
    ..mechanisms of wound healing and scarring, the most common cause for loss of vision necessitating in corneal transplantation. Genetic defects in the cornea in humans can result in serious loss of visual function with accompanying ..
  60. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 2001
    ..in intense ocular inflammation, irreversible stromal scarring of the cornea, blindness, and the need for corneal transplantation. The objective of this project is to improve our understanding of both the bacterial factors and the host ..
  61. CORNEAL DONOR STUDY--SPECULAR MICROSCOPY ANCILLARY STUDY
    Jonathan Lass; Fiscal Year: 2003
    ..interest by considerable public health importance with regard to the pool of available donor tissue for corneal transplantation. The CDS is relying on a clinical assessment of graft survival for its primary outcome assessment...
  62. REGULATION OF CORNEAL GRAFT FAILURE
    LINDA TOTH; Fiscal Year: 1992
    DESCRIPTION: (Investigator's Abstract). Corneal transplantation is the most common and most successful form of solid organ human transplantation...
  63. FAS L INDUCED APOPTOSIS IN CORNEA TRANSPLANTATION
    PATRICK STUART; Fiscal Year: 2004
    The acceptance rate for corneal transplantation, one of the most common types of transplantation performed, is typically between 80- 90%...