segmental mastectomy

Summary

Summary: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.

Top Publications

  1. ncbi Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:1233-41. 2002
  2. ncbi Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
  3. ncbi Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy
    S Eva Singletary
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 444, Houston TX 77030 4095, USA
    Am J Surg 184:383-93. 2002
  4. ncbi Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial
    Harry Bartelink
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 25:3259-65. 2007
  5. ncbi Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853--a study by the EORTC Breast Cancer Cooperative Group and
    Nina Bijker
    Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 24:3381-7. 2006
  6. ncbi Role for intraoperative margin assessment in patients undergoing breast-conserving surgery
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Ann Surg Oncol 14:1458-71. 2007
  7. ncbi The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery
    Tara L Huston
    New York Presbyterian Hospital, Cornell University, 425 East 61st Street, 8th Floor, New York, NY 10021, USA
    Am J Surg 192:509-12. 2006
  8. ncbi Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality
    Vincent Vinh-Hung
    Oncology Center, Academic Hospital, Vrije Universiteit Brussel, Jette, Belgium
    J Natl Cancer Inst 96:115-21. 2004
  9. ncbi Definition of postlumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips
    Hadassah Goldberg
    Department of Oncology, Rambam Medical Center, Haifa, Israel
    Int J Radiat Oncol Biol Phys 63:209-13. 2005
  10. ncbi Ductal carcinoma in situ, complexities and challenges
    Gregory D Leonard
    Cancer Therapeutics Branch, National Cancer Institute, Bethesda, MD 20889 5105, USA
    J Natl Cancer Inst 96:906-20. 2004

Detail Information

Publications257 found, 100 shown here

  1. ncbi Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:1233-41. 2002
    ..In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer...
  2. ncbi Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
    ..We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery...
  3. ncbi Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy
    S Eva Singletary
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 444, Houston TX 77030 4095, USA
    Am J Surg 184:383-93. 2002
    ..This review examines published reports about standard and innovative approaches to assessing surgical margins, the clinical significance of margin size, and risk factors for positive margins...
  4. ncbi Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial
    Harry Bartelink
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 25:3259-65. 2007
    ..To investigate the long-term impact of a boost radiation dose of 16 Gy on local control, fibrosis, and overall survival for patients with stage I and II breast cancer who underwent breast-conserving therapy...
  5. ncbi Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853--a study by the EORTC Breast Cancer Cooperative Group and
    Nina Bijker
    Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 24:3381-7. 2006
    ..We analyzed the efficacy of RT with 10 years follow-up on both the overall risk of local recurrence (LR) and related to clinical, histologic, and treatment factors...
  6. ncbi Role for intraoperative margin assessment in patients undergoing breast-conserving surgery
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Ann Surg Oncol 14:1458-71. 2007
    ..We investigated whether intraoperative margin assessment aids in obtaining negative margins, and to evaluate the local control thus achieved...
  7. ncbi The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery
    Tara L Huston
    New York Presbyterian Hospital, Cornell University, 425 East 61st Street, 8th Floor, New York, NY 10021, USA
    Am J Surg 192:509-12. 2006
    ....
  8. ncbi Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality
    Vincent Vinh-Hung
    Oncology Center, Academic Hospital, Vrije Universiteit Brussel, Jette, Belgium
    J Natl Cancer Inst 96:115-21. 2004
    ..The objective of the study was to investigate whether radiotherapy or its omission after breast-conserving surgery has measurable consequences on local tumor growth and patient survival...
  9. ncbi Definition of postlumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips
    Hadassah Goldberg
    Department of Oncology, Rambam Medical Center, Haifa, Israel
    Int J Radiat Oncol Biol Phys 63:209-13. 2005
    ..To compare the location and extent of the tumor bed as defined by surgical clips and computed tomography (CT) scans, after lumpectomy, for electron boost planning as part of breast radiotherapy...
  10. ncbi Ductal carcinoma in situ, complexities and challenges
    Gregory D Leonard
    Cancer Therapeutics Branch, National Cancer Institute, Bethesda, MD 20889 5105, USA
    J Natl Cancer Inst 96:906-20. 2004
    ..Ongoing and recently completed studies should provide information on outcomes in patients treated with lumpectomy alone and on the effectiveness of aromatase inhibitors as an alternative to tamoxifen...
  11. ncbi Breast conservation after neoadjuvant chemotherapy: the MD Anderson cancer center experience
    Allen M Chen
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 22:2303-12. 2004
    ..To determine patterns of local-regional recurrence (LRR) and ipsilateral breast tumor recurrence (IBTR) among patients treated with breast conservation therapy after neoadjuvant chemotherapy...
  12. pmc Intraoperative ultrasound is associated with clear lumpectomy margins for palpable infiltrating ductal breast cancer
    M M Moore
    Martha Jefferson Physician Hospital Organization, Charlottesville, Virginia 22903, USA
    Ann Surg 233:761-8. 2001
    ..To evaluate the efficacy of intraoperative ultrasound in obtaining adequate surgical margins in women undergoing lumpectomy for palpable breast cancer...
  13. pmc The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial
    S M Bentzen
    Lancet Oncol 9:331-41. 2008
    ..We tested two dose levels of a 13-fraction schedule against the standard regimen with the aim of measuring the sensitivity of normal and malignant tissues to fraction size...
  14. ncbi Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 26:2373-8. 2008
    ..To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy...
  15. ncbi Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity
    Daniel M Landis
    Joint Center for Radiation Therapy Residency Training Program, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 67:1299-308. 2007
    ..We examined the interobserver variability in delineation of the lumpectomy cavity among four academic radiation oncologists who specialize in the treatment of breast cancer...
  16. ncbi Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial
    J Roger Owen
    Department of Oncology, Gloucestershire Oncology Centre, Cheltenham, UK
    Lancet Oncol 7:467-71. 2006
    ..0 Gy over 5 weeks. In a randomised trial, we tested whether fewer, larger fractions were at least as safe and as effective as standard regimens. In this analysis, we assessed the long-term results of tumour control in the same population...
  17. ncbi Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy
    Dorothee Twardella
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Radiother Oncol 69:145-53. 2003
    ..The influence of therapy modalities, personal characteristics and individual DNA repair capacity on the risk of acute skin toxicity was thus evaluated...
  18. ncbi Influence of breast cancer margin assessment method on the rates of positive margins and residual carcinoma
    Jane E Mendez
    Department of Surgery, Boston Medical Center, Boston University School of Medicine, 88 E Newton St, D 509, Boston, MA 02118, USA
    Am J Surg 192:538-40. 2006
    ..We hypothesized that the method of breast cancer margin assessment may be associated with different rates of positive margins and residual carcinoma...
  19. ncbi Accelerated partial breast irradiation as a part of breast conservation therapy
    Douglas W Arthur
    Radiation Oncology Department, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA
    J Clin Oncol 23:1726-35. 2005
  20. ncbi The frequency of ipsilateral second tumors after breast-conserving surgery for DCIS: a population based analysis
    Joan L Warren
    Health Services and Economics Branch Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7344, USA
    Cancer 104:1840-8. 2005
    ..This analysis of women treated with breast-conserving surgery (BCS) evaluated the impact of radiation therapy (RT) in patient outcomes...
  21. ncbi Target volume delineation for partial breast radiotherapy planning: clinical characteristics associated with low interobserver concordance
    Ross P Petersen
    Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, Victoria, Canada
    Int J Radiat Oncol Biol Phys 69:41-8. 2007
    ..To examine variability in target volume delineation for partial breast radiotherapy planning and evaluate characteristics associated with low interobserver concordance...
  22. ncbi Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, Division of Pathology, and Breast Committee, Pittsburgh, PA, USA
    J Clin Oncol 20:4141-9. 2002
    ....
  23. ncbi It is possible to omit postoperative irradiation in a highly selected group of elderly breast cancer patients
    T Gruenberger
    Department of General Surgery, University of Vienna, Austria
    Breast Cancer Res Treat 50:37-46. 1998
    ..These data have to be confirmed in a prospectively randomized fashion...
  24. ncbi Long-term survival outcomes following breast cancer surgery in Western Australia
    Katrina Spilsbury
    Western Australian Safety and Quality of Surgical Care Project, Centre for Health Services Research, School of Population Health, University of Western Australia, Crawley, Australia
    ANZ J Surg 75:625-30. 2005
    ..The aim of the present study was to investigate how hospital, social and demographic factors were associated with survival outcomes from surgically treated breast cancer for all women living in Western Australia...
  25. ncbi Fibrin sealant reduces the duration and amount of fluid drainage after axillary dissection: a randomized prospective clinical trial
    M Moore
    Department of Surgery and the Tissue Adhesive Center, University of Virginia, Charlottesville, USA
    J Am Coll Surg 192:591-9. 2001
    ..The viral safety of the product was also supported...
  26. pmc Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial
    Heather A Jones
    Department of Radiation Oncology, University of Pittsburgh Cancer Center, Pittsburgh, PA, USA
    J Clin Oncol 27:4939-47. 2009
    ..To investigate the long-term impact of pathologic characteristics and an extra boost dose of 16 Gy on local relapse, for stage I and II invasive breast cancer patients treated with breast conserving therapy (BCT)...
  27. ncbi Persistent differences in sociodemographic determinants of breast conserving treatment despite overall increased adoption
    Mary Ann Gilligan
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Med Care 40:181-9. 2002
    ..Use of breast-conserving treatment (BCT) has previously demonstrated variability by sociodemographic factors...
  28. ncbi The surgical margin status after breast-conserving surgery: discussion of an open issue
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 113:397-402. 2009
    ..Radiation therapy could be a good option in the management of these cases, but further evidence is needed to establish the real impact of clear surgical margins on local control of disease and, furthermore, on survival...
  29. pmc Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey
    Alphonse Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Cox 302, 100 Blossom Street, Boston, MA 02114, USA
    Ann Surg 241:629-39. 2005
    ....
  30. ncbi A prospective, randomized, controlled, multicenter study of a real-time, intraoperative probe for positive margin detection in breast-conserving surgery
    Tanir M Allweis
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Surg 196:483-9. 2008
    ....
  31. ncbi A comparison of ink-directed and traditional whole-cavity re-excision for breast lumpectomy specimens with positive margins
    G R Gibson
    Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Ann Surg Oncol 8:693-704. 2001
    ....
  32. ncbi Intraoperative margin assessment and re-excision rate in breast conserving surgery
    F J Fleming
    Department of Surgery, St Vincent s University Hospital, University College Dublin, Elm Park, Dublin 4, Ireland
    Eur J Surg Oncol 30:233-7. 2004
    ..The aim of this study was to assess the efficacy of intraoperative margin assessment in obtaining clear margins in conserving surgery for breast cancer...
  33. pmc Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study
    Christine B Ambrosone
    Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 8:R40. 2006
    ..We hypothesized that polymorphisms encoding reduced or absent activity in the GSTs might result in greater risk for radiation-associated toxicity...
  34. ncbi Predictors of surgical margin status in breast-conserving surgery within a breast screening program
    Emil D Kurniawan
    Department of Surgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, 3050, Australia
    Ann Surg Oncol 15:2542-9. 2008
    ..We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at the first operation...
  35. ncbi Importance of lymphatic mapping in ductal carcinoma in situ (DCIS): why map DCIS?
    C E Cox
    Department of Surgery, University of South Florida College of Medicine, Tampa, USA
    Am Surg 67:513-9; discussion 519-21. 2001
    ..No "high-risk" group of patients can be identified for selective sentinel lymph node biopsy...
  36. ncbi Prevalence and predictive factors for the detection of carcinoma in cavity margin performed at the time of breast lumpectomy
    Iulia Tengher-Barna
    Service d Anatomie et de Cytologie Pathologiques, CHU Jean Verdier AP HP, Bondy, France
    Mod Pathol 22:299-305. 2009
    ..Our study confirms that the systematic practice of cavity margin resection avoids surgical re-excision and reduces the likelihood of underestimating the extent of the tumor...
  37. ncbi Breast carcinomas of limited extent: frequency, radiologic-pathologic characteristics, and surgical margin requirements
    D R Faverly
    Department of Pathology, Radboud University Hospital, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer 91:647-59. 2001
    ..The mammographic and pathologic criteria for the identification of tumors with limited extent are not yet established; furthermore, the optimal extent of the surgical excision and the method for margin examination are controversial...
  38. ncbi Importance of routine cavity sampling in breast conservation surgery
    J C Hewes
    The Breast Unit, William Harvey Hospital, Kennington Road, Willesborough, Kent, UK
    Br J Surg 96:47-53. 2009
    ..This study compared four groups of patients to determine the significance of margins and CB histology on tumour characteristics and outcome...
  39. ncbi Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women
    Giovanni Battista Ivaldi
    Department of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Int J Radiat Oncol Biol Phys 72:485-93. 2008
    ..To report the acute and preliminary data on late toxicity of a pilot study of boost with electron intraoperative therapy followed by hypofractionated external beam radiotherapy (HEBRT) of the whole breast...
  40. ncbi Factors correlating with reexcision after breast-conserving therapy
    M R Bani
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Erlangen, Germany
    Eur J Surg Oncol 35:32-7. 2009
    ..Several factors, including tumor size, multifocality, and an extensive in situ component, may be associated with a higher rate of repeat operations due to positive margins. This study included mammographic density in the analysis...
  41. ncbi Radiotherapy omission after breast-conserving surgery is associated with reduced breast cancer-specific survival in elderly women with breast cancer
    Pauline T Truong
    British Columbia Cancer Agency, Vancouver Island Centre, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, BC, Canada V8R 6V5
    Am J Surg 191:749-55. 2006
    ..To evaluate the effect of radiotherapy (RT) omission on survival in older breast cancer patients treated with breast-conserving surgery...
  42. ncbi Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence
    C C Park
    Joint Center for Radiation Therapy, Boston, MA 02215, USA
    J Clin Oncol 18:1668-75. 2000
    ..To examine the relationship between pathologic margin status and outcome at 8 years after breast-conserving surgery and radiation therapy...
  43. ncbi Predictors of reexcision findings and recurrence after breast conservation
    Melanie C Smitt
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 57:979-85. 2003
    ..To identify predictors of reexcision findings and local recurrence in the setting of breast-conserving therapy with radiation...
  44. pmc Comparative morbidity of axillary lymph node dissection and the sentinel lymph node technique: implications for patients with breast cancer
    Allan W Silberman
    Divisions of Surgical Oncology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Ann Surg 240:1-6. 2004
    ..To assess our long-term complications from complete axillary lymph node dissection (AXLND) in patients with breast cancer...
  45. ncbi Patterns of breast recurrence in a pilot study of brachytherapy confined to the lumpectomy site for early breast cancer with six years' minimum follow-up
    Francisco Perera
    Department of Radiation Oncology, London Regional Cancer Centre, London, Ontario, Canada
    Int J Radiat Oncol Biol Phys 57:1239-46. 2003
    ....
  46. pmc Impact of preoperative versus postoperative chemotherapy on the extent and number of surgical procedures in patients treated in randomized clinical trials for breast cancer
    Judy C Boughey
    Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 244:464-70. 2006
    ..To determine the effect of preoperative chemotherapy on the volume of tissue excised and the number of breast operations in patients undergoing breast-conserving therapy (BCT)...
  47. pmc Indicators of breast cancer severity and appropriateness of surgery based on hospital administrative data in the Lazio Region, Italy
    Patrizia Schifano
    Department of Epidemiology, Health Local Unit RME, Rome, Italy
    BMC Public Health 6:25. 2006
    ..The aim of this study is to evaluate the use of hospital administrative data to determine breast cancer severity and the appropriateness of surgical treatment...
  48. ncbi Risk factors for local recurrence in patients with invasive breast cancer and negative surgical margins of excision. Where are we and where are we going?
    Stuart J Schnitt
    Am J Clin Pathol 120:485-8. 2003
  49. ncbi Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 55:1216-25. 2003
    ..The study objective was to evaluate whether DNA repair data determined in vitro are correlated with the occurrence of acute side effects during radiotherapy...
  50. ncbi Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial
    U Veronesi
    Department of Senology, European Institute of Oncology, Milano, Italy
    Ann Oncol 12:997-1003. 2001
    ..Breast-conserving surgery followed by radiotherapy is a widely accepted form of treatment in patients with breast cancer of limited extent. Many attempts have been made to identify subgroups of patients who might avoid radiotherapy...
  51. ncbi Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer
    Kevin S Hughes
    Avon Comprehensive Breast Evaluation Center, Breast Ovarian Cancer Genetics and Risk Assessment Program, Massachusetts General Hospital, Division of Surgical Oncology, Boston 02114, USA
    N Engl J Med 351:971-7. 2004
    ..In women 70 years of age or older who have early breast cancer, it is unclear whether lumpectomy plus tamoxifen is as effective as lumpectomy followed by tamoxifen plus radiation therapy...
  52. pmc Oncoplastic techniques allow extensive resections for breast-conserving therapy of breast carcinomas
    Krishna B Clough
    Department of General and Breast Surgery, Institut Curie, Paris, France
    Ann Surg 237:26-34. 2003
    ..To assess the oncologic and cosmetic outcomes in women with breast carcinoma who were treated with breast-conserving therapy using oncoplastic techniques with concomitant symmetrization of the contralateral breast...
  53. ncbi Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence
    T P Olson
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Ann Surg Oncol 14:2953-60. 2007
    ..We retrospectively analyzed records of patients who received breast-conserving therapy with intraoperative FSA of the lumpectomy cavity to assess re-excision rates and local control...
  54. ncbi Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
    Lancet 353:1993-2000. 1999
    ..We did a double-blind randomised controlled trial to find out whether lumpectomy, radiation therapy, and tamoxifen was of more benefit than lumpectomy and radiation therapy alone for DCIS...
  55. ncbi Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy
    U Veronesi
    Division of Senology, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
    Ann Oncol 16:383-8. 2005
    ..The aim of the study was to assess the role of axillary radiotherapy (RT) in reducing axillary metastases in patients with early breast cancer who did not receive axillary dissection...
  56. ncbi Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast
    Lawrence J Solin
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer 103:1137-46. 2005
    ..The objective of the current study was to determine the long-term outcome after breast-conservation surgery followed by definitive breast irradiation for women with mammographically detected DCIS of the breast...
  57. ncbi Relationship between excision volume, margin status, and tumor size with the development of local recurrence in patients with ductal carcinoma-in-situ treated with breast-conserving therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Surg Oncol 76:245-54. 2001
    ....
  58. ncbi Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial
    Joan Houghton
    Clinical Trials Group, Department of Surgery, Royal Free and University College Medical School, Charles Bell House, London W1W 7EJ, UK
    Lancet 362:95-102. 2003
    ..We aimed to assess the effectiveness of adjuvant radiotherapy and tamoxifen...
  59. ncbi Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma--5-year results of a randomized trial
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    Int J Radiat Oncol Biol Phys 69:694-702. 2007
    ..To report the 5-year results of a randomized study comparing the survival and cosmetic results of breast-conserving treatment with partial breast irradiation (PBI) or conventional whole breast irradiation (WBI)...
  60. ncbi Limited-field radiation therapy in the management of early-stage breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    J Natl Cancer Inst 95:1205-10. 2003
    ..e., limited-field radiation therapy) in selected patients treated with breast-conserving therapy and compared them with results of matched breast-conserving therapy patients who underwent whole-breast radiation therapy...
  61. ncbi Gene expression profiles of primary breast carcinomas from patients at high risk for local recurrence after breast-conserving therapy
    Bas Kreike
    Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Clin Cancer Res 12:5705-12. 2006
    ..We used cDNA microarray analysis to identify gene expression profiles associated with local recurrence...
  62. ncbi Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Semin Oncol 28:400-18. 2001
    ..It does suggest, however, that, in the treatment of DCIS, the appropriate use of current and better therapeutic agents that become available could diminish the significance of breast cancer as a public health problem...
  63. ncbi Magnetic resonance imaging for preoperative evaluation of breast cancer: a comparative study with mammography and ultrasonography
    Tunetake Hata
    First Department of Surgery, Hokkaido University, Kita 15 Nishi 7, Kita ku, 060 8638 Sapporo, Japan
    J Am Coll Surg 198:190-7. 2004
    ..We investigated the clinical usefulness of magnetic resonance imaging of the breast in the therapy of breast cancer and we compared it with mammography and ultrasonography...
  64. ncbi The impact of preoperative MRI on breast-conserving surgery of invasive cancer: a comparative cohort study
    K E Pengel
    Department of Radiology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital NKI AVL, Amsterdam, The Netherlands
    Breast Cancer Res Treat 116:161-9. 2009
    ..To assess whether preoperative contrast-enhanced magnetic resonance imaging (MRI) of the breast influences the rate of incomplete tumor excision...
  65. ncbi Local recurrences after different treatment strategies for ductal carcinoma in situ of the breast: a population-based study in the East Netherlands
    Arjan P Schouten van der Velden
    Department of Surgical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 69:703-10. 2007
    ..Outcomes after different treatment strategies for ductal carcinoma in situ (DCIS) of the breast were analyzed for a geographically defined population in the East Netherlands...
  66. ncbi The management of ductal carcinoma in situ of the breast: a screened population-based analysis
    Eileen Rakovitch
    Department of Radiation Oncology and Health Policy and Evaluation, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont, Canada
    Breast Cancer Res Treat 101:335-47. 2007
    ..We report a patterns of care study of women with DCIS to better understand the gap between evidence-based knowledge and the management of DCIS...
  67. ncbi Intra-operative sonography: a valuable aid during breast-conserving surgery for occult breast cancer
    Anton Haid
    Department of General and Thoracic Surgery, Landeskrankenhaus Feldkirch, Teaching Hospital of Innsbruck University, Carinagasse 47 49, 6800, Feldkirch, Austria
    Ann Surg Oncol 14:3090-101. 2007
    ..Together with pre-operative marking of the mass, intra-operative imaging provides invaluable clues. This study was designed to evaluate the usefulness of intra-operative sonography in the hands of the surgeon...
  68. pmc Locoregional recurrence of triple-negative breast cancer after breast-conserving surgery and radiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer 115:946-51. 2009
    ..The results of radiation on the local control of triple receptor-negative breast cancer (negative estrogen [ER], progesterone [PR], and HER-2/neu receptors) was studied...
  69. ncbi Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials
    A C Voogd
    Eindhoven Cancer Registry, The Netherlands Cancer Institute, Eindhoven, The Netherlands
    J Clin Oncol 19:1688-97. 2001
    ..Risk factors for local and distant recurrence after breast-conserving therapy and mastectomy were compared to define guidelines for the decision making between both treatments...
  70. ncbi Is the reexcision rate higher if breast conservation surgery is performed by surgical trainees?
    Krishna Moorthy
    Breast Care Unit, Department of Surgery, Bedford Hospital, Bedford, MK42 9DJ, United Kingdom
    Am J Surg 188:45-8. 2004
    ..The aim of this study was to compare the reexcision and local recurrence rates between consultants (attending surgeons) and surgical trainees (residents) after breast conservation surgery...
  71. ncbi Accelerated treatment of breast cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 19:1993-2001. 2001
    ..The goals of the study were to determine whether treatment time can be reduced and whether elective treatment of the entire breast is necessary...
  72. ncbi Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma
    M Morrow
    American College of Surgeons Commission on Cancer, Chicago, IL, USA
    J Clin Oncol 19:2254-62. 2001
    ..CONCLUSION: Despite strong evidence supporting the use of BCT, the majority of women continue to be treated with mastectomy. Predictors of the use of BCT do not correspond to those suggested in guidelines...
  73. ncbi Intraoperative ultrasound-guided excision of nonpalpable breast lesions
    I C Bennett
    Department of, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, and Wesley Hospital, Brisbane, Australia
    World J Surg 29:369-74. 2005
    ....
  74. ncbi Quality of life following breast-conserving therapy or mastectomy: results of a 5-year prospective study
    Jutta Engel
    Munich Field Study, Munich Cancer Registry, Ludwig Maximilians University, Munich, Germany
    Breast J 10:223-31. 2004
    ..Body image, sexual functioning, and lifestyle disruption scores did not improve over time. BCT should be encouraged in all age groups. Coping with appearance change should be addressed in patient interventions...
  75. ncbi Fifteen-year prognostic discriminants for invasive breast carcinoma: National Surgical Adjuvant Breast and Bowel Project Protocol-06
    E R Fisher
    National Surgical Adjuvant Breast and Bowel Project Pathology Center, Pittsburgh, Pennsylvania, USA
    Cancer 91:1679-87. 2001
    ....
  76. ncbi Trends in the treatment of ductal carcinoma in situ of the breast
    Nancy N Baxter
    Division of Surgical Oncology and School of Public Health, University of Minnesota, Minneapolis 55455, USA
    J Natl Cancer Inst 96:443-8. 2004
    ..This study was designed to evaluate the use of surgery and radiation therapy in treating DCIS...
  77. pmc Patterns and correlates of local therapy for women with ductal carcinoma-in-situ
    Steven J Katz
    Department of Medicine and Health Management and Policy, University of Michigan, 300 N Ingalls, Ste 7E12, Box 0429, Ann Arbor, MI 48109 0429, USA
    J Clin Oncol 23:3001-7. 2005
    ....
  78. ncbi Does intraductal breast cancer spread in a segmental distribution? An analysis of residual tumour burden following segmental mastectomy using tumour bed biopsies
    A D Jenkinson
    The Breast Surgery Unit, St Bartholomew s Hospital, The Royal Hospitals NHS Trust, West Smithfield, London EC1A 7BE, UK
    Eur J Surg Oncol 27:21-5. 2001
    ....
  79. ncbi Prospective study of wide excision alone for ductal carcinoma in situ of the breast
    Julia S Wong
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:1031-6. 2006
    ..It has been hypothesized that wide excision alone with margins > or = 1 cm may be adequate treatment for small, grade 1 or 2 ductal carcinoma in situ (DCIS). To test this hypothesis, we conducted a prospective, single-arm trial...
  80. ncbi Intraoperative radiotherapy given as a boost for early breast cancer: long-term clinical and cosmetic results
    Claire Lemanski
    Department of Radiation Oncology, Val d Aurelle Cancer Institute, Montpellier, France
    Int J Radiat Oncol Biol Phys 64:1410-5. 2006
    ..Intraoperative radiotherapy (IORT) could be an alternative to overcome these...
  81. ncbi Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy
    Funda Meric
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 97:926-33. 2003
    ....
  82. ncbi Location and extent of positive resection margins and ductal carcinoma in situ in lumpectomy specimens of ductal breast carcinoma examined with a microscopic three-dimensional view
    Kien T Mai
    Division of Anatomical Pathology, Department of Laboratory Medicine, Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada
    Breast J 9:33-8. 2003
    ..Incomplete excision of the ductal carcinoma and the wide positive margins are most likely caused by the failure to estimate the extent and location of DCIS...
  83. ncbi [The importance of surgical margins in conservative surgery for breast cancer]
    Isabel T Rubio
    Cirugía General, Instituto Oncologico, Centro Medico Teknon, Barcelona, Spain
    Cir Esp 79:3-9. 2006
    ..Therefore, it is essential to optimize intraoperative examination of margins as well as to explore new techniques that would achieve the greatest possible percentage of negative margins...
  84. ncbi Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy
    Martin Keisch
    Department of Radiation Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Int J Radiat Oncol Biol Phys 55:289-93. 2003
    ..We present the results of the initial clinical testing of the MammoSite balloon breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy...
  85. ncbi Factors associated with surgical options for breast carcinoma
    Anees B Chagpar
    Division of Surgical Oncology, Department of Surgery, University of Louisville, KY, USA
    Cancer 106:1462-6. 2006
    ..The current study evaluated the impact of patient and physician factors on surgical decision-making...
  86. ncbi Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation
    H Bartelink
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam
    N Engl J Med 345:1378-87. 2001
    ..We evaluated the effect of a supplementary dose of radiation to the tumor bed on the rates of local recurrence among patients who received radiotherapy after breast-conserving surgery for early breast cancer...
  87. doi Boost or not
    David A L Morgan
    J Clin Oncol 26:1013-4; author reply 1014. 2008
  88. ncbi Intraoperative radiotherapy (IORT) as a boost in patients with early-stage breast cancer -- acute toxicity
    Uta Kraus-Tiefenbacher
    Department of Radiation Oncology, Universitatsklinikum Mannheim, Germany
    Onkologie 29:77-82. 2006
    ..We report on acute toxicities as well as the early cosmetic outcome of patients receiving intraoperative radiotherapy (IORT) followed by whole-breast radiotherapy (WBRT) compared to patients treated with standard WBRT alone...
  89. ncbi Preemptive analgesia with bupivacaine for segmental mastectomy
    Manuel C Vallejo
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Reg Anesth Pain Med 31:227-32. 2006
    ..purpose of this study is to determine if preemptive and/or postoperative local anesthetic infiltration of bupivacaine in patients undergoing segmental mastectomy results in less postoperative pain compared with patients receiving placebo.
  90. ncbi Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins
    Juan C Cendan
    Department of Surgery, University of Florida, College of Medicine, Gainesville, FL 32610 0286, USA
    J Am Coll Surg 201:194-8. 2005
    ..We review our experience in breast-conservation therapy (BCT) at the University of Florida (Gainesville) to determine the effectiveness of this approach...
  91. ncbi Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a phase I-II study and initial findings of a randomized phase III trial
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    J Surg Oncol 80:121-8; discussion 129. 2002
    ....
  92. ncbi Information on radiation treatment in patients with breast cancer: the advantages of the linked medicare and SEER data. Surveillance, Epidemiology and End Results
    X Du
    Department of Internal Medicine and Center on Aging, University of Texas Medical Branch, Galveston 77555 0860, USA
    J Clin Epidemiol 52:463-70. 1999
    ..The previously reported geographic variations in the use of radiotherapy for breast cancer may be due in part to underreporting of radiotherapy in some areas...
  93. pmc The significance of the Van Nuys prognostic index in the management of ductal carcinoma in situ
    Onur Gilleard
    The Royal Devon and Exeter Breast Cancer Unit, Exeter, Devon EX25DW, UK
    World J Surg Oncol 6:61. 2008
    ..This paper independently assesses the prognostic validity of the VNPI in a British population...
  94. ncbi Do additional shaved margins at the time of lumpectomy eliminate the need for re-excision?
    Allyson F Jacobson
    Department of General Surgery, Division of Breast Surgery, Beth Israel Medical Center, 10 Union Square East, Ste 4E, New York, NY 10003, USA
    Am J Surg 196:556-8. 2008
    ..Re-excision rates for positive margins have been reported to be greater than 50%. The purpose of our study was to determine if removing additional shaved margins from the lumpectomy cavity at the time of lumpectomy reduces re-excisions...
  95. ncbi Female patients with breast carcinoma age 30 years and younger have a poor prognosis: the M.D. Anderson Cancer Center experience
    Q Xiong
    Division of Cancer Medicine; University of Texas M. D. Anderson Cancer Center; Houston, Texas 77030, USA
    Cancer 92:2523-8. 2001
    ..CONCLUSIONS: Women who are diagnosed with breast carcinoma at an age < or = 30 years appear to have a poorer prognosis compared with that for their older counterparts...
  96. ncbi Analysis of ipsilateral breast tumor recurrences after breast-conserving treatment based on the classification of true recurrences and new primary tumors
    Yoshifumi Komoike
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Breast Cancer 12:104-11. 2005
    ..The aim of this study is to clarify the biological difference between TR and NP, and to show the clinical significance of classifying IBTR into these two types of recurrence...
  97. ncbi Is excision alone adequate treatment for low-risk ductal carcinoma-in-situ of the breast?
    Lawrence J Solin
    J Clin Oncol 24:1017-9. 2006
  98. ncbi Accelerated partial breast irradiation: a change in treatment paradigm for early stage breast cancer
    Douglas Arthur
    J Surg Oncol 84:185-91. 2003
  99. pmc A randomized trial comparing axillary dissection to no axillary dissection in older patients with T1N0 breast cancer: results after 5 years of follow-up
    Gabriele Martelli
    Unit of Diagnostic Oncology and Out Patient Clinic, Istituto Nazionale Tumori, Milan, Italy
    Ann Surg 242:1-6; discussion 7-9. 2005
    ..We addressed this issue in a randomized trial comparing axillary dissection with no axillary dissection in older patients with T1N0 breast cancer...
  100. ncbi A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer
    Nicole Hébert-Croteau
    Direction des Systèmes de Soins et Services, Institut National de Sante Publique du Quebec, Canada
    Breast Cancer Res Treat 88:187-96. 2004
    ..Practice guidelines have set a maximum waiting time to radiation therapy for breast cancer. We evaluated if delaying radiotherapy resulted in worse outcomes in a large cohort of women with node-negative breast cancer...
  101. ncbi Factors influencing choice between mastectomy and lumpectomy for women in the Carolinas
    S Benedict
    College of Nursing, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Surg Oncol 76:6-12. 2001
    ..The Carolinas have been documented to have a low rate of breast-conserving surgery. The purpose of this study was to determine factors that influence women's choice between mastectomy and lumpectomy...

Research Grants63

  1. Wavefront Corrected Multimodal Optical Coherence and Two-Photon Microscopy for Ra
    Yuankai Kenny Tao; Fiscal Year: 2012
    ..The proposed multimodal non-destructive optical imaging tool will allow for rapid intraoperative assessment of surgical margins as a means of reducing the morbidity and mortality associated with breast cancer. ..
  2. Mechanisms Underlying SES Disparities in Breast Cancer Mortality
    Liliana E Pezzin; Fiscal Year: 2013
    ....
  3. Erythropoietin and Breast Cancer Stem Cells
    Frank Pajonk; Fiscal Year: 2013
    ..The long-term goals of this proposal are to study under which circumstances Epo interferes with BCSC numbers and treatment outcome. Understanding the pathways may lead to novel combined treatments that will improve BC treatment outcome. ..
  4. A Presurgery Hypnosis Training Program for Nurse Anesthetists
    Guy H Montgomery; Fiscal Year: 2011
    ..Aim 3: To investigate the relative effectiveness of the hypnosis training program from the perspective of the institution (hospitals). ..
  5. Costs and Complications of Radiotherapy Modalities
    Heather Taffet Gold; Fiscal Year: 2012
    ..This is particularly important for this new technology that has higher up-front costs with no known additional therapeutic benefit compared to the standard of care. ..
  6. Effectiveness of Pre-Operative MRI in Breast Cancer Surgery and Outcomes
    Tracy Onega; Fiscal Year: 2013
    ..In this era of new technologies and health care reform, identifying if and when advanced modalities benefit patients is of the utmost importance to both patients and resource allocation efforts. ..
  7. Surgical Site and Clostridium difficile Infections after Ambulatory Surgery
    Margaret A Olsen; Fiscal Year: 2012
    ..This study will provide significant new information to enhance patient safety and improve outcomes for patients undergoing common surgical procedures in ambulatory settings. ..
  8. Targeted Nanoprobes For Intraoperative optical Imaging of Breast Cancer Margins
    Lily Yang; Fiscal Year: 2012
    ....
  9. The tumorigenic potential of tumor adjacent histologically normal breast tissue.
    KRISTINA ANTONIA TRUJILLO; Fiscal Year: 2013
    ..This proposal challenges the assumption that local recurrence is always due to residual cancer cells and, therefore, has implications on the adequacy of current standards for surgical margins in breast cancer. ..
  10. A Novel Optical Spectral Imaging System for Rapid Imaging of Breast Tumor Margins
    Nirmala Ramanujam; Fiscal Year: 2013
    ..A tool for intra-operative margin assessment is significantly relevant to public in that it will contribute to a decrease in re-excision surgeries in patients with breast cancer. ..
  11. A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment
    JONATHAN QUINCY BROWN; Fiscal Year: 2012
    ..Successful completion of the R21 will result in a critical first step towards a clinically-viable system for in vivo fluorescence histology of breast tumor margins. ..
  12. Image Quality Improvement and Breast Compression Reduction in Breast Tomosynthesi
    Ioannis Sechopoulos; Fiscal Year: 2013
    ....
  13. Decision-making regarding radiation therapy in breast cancer"
    Rinaa S Punglia; Fiscal Year: 2010
    ..The proposed combined education and research program, in addition to strong mentorship, will provide the candidate with the skills and experience necessary for a career as an independent outcomes researcher in breast cancer. ..
  14. Statistical Methods in Cancer Control and Epidemiology
    Bradley P Carlin; Fiscal Year: 2010
    ....
  15. MEMS Based Intraoperative Photoacoustic Imaging
    Huabei Jiang; Fiscal Year: 2013
    ....
  16. Beta Camera and Laparoscopic Probe for Surgical Cancer Removal.
    FARHAD DAGHIGHIAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. MULTILEVEL COMPLIANCE MODEL OF BREAST CANCER TREATMENTS
    Mary Fennell; Fiscal Year: 1999
    ....
  18. TAS::75 0849::TAS SBIR TOPIC 307 PHASE I NOVEL IMAGING AGENTS TO EXPAND THE CLIN
    BRYAN WALSER; Fiscal Year: 2011
    ..Furthermore, because they activate rapidly, they can be used to guide surgery. Thus, the probes described here have the potential to both reduce the need for multiple surgeries and improve overall patient outcome. ..
  19. Institutional variation in surgical care for breast cancer in US community hospit
    CAPRICE CHRISTIAN GREENBERG; Fiscal Year: 2010
    ..S. healthcare system. ..
  20. PRIMARY BREAST CANCER THERAPY GROUP
    Henry Shibata; Fiscal Year: 1980
    ..1) Protocol B-06, which is designed to determine whether local therapy in the form of Total Mastectomy or Segmental Mastectomy plus breast irradiation is comparable to Segmental Mastectomy...
  21. PRIMARY BREAST CANCER THERAPY GROUP (NSABP)
    Richard Margolese; Fiscal Year: 1980
    ..on disease-free interval or survival, a second surgical prospective trial was undertaken to evaluate Segmental Mastectomy with and without breast radiation vs. Total Mastectomy...
  22. PRIMARY BREAST CANCER THERAPY GROUP-NSABP
    Daniel Karp; Fiscal Year: 1991
    ..38 patients per year based on the opening of NSABP breast protocols to patients who have undergone segmental mastectomy, education of surgeons regarding referral of node-negative and intraductal breast cancer patients and ..
  23. Intra-operative specimen tomosynthesis for margin assessment in breast surgery
    EMRE TOKER; Fiscal Year: 2009
    ....
  24. PRIMARY BREAST CANCER THERAPY GROUP
    Roger Poisson; Fiscal Year: 1991
    ..a trial of breast preservation (protocol 6) is underway within the NSABP to compare the value of segmental mastectomy with and without breast irradiation vs. total mastectomy...
  25. Cost-Effectiveness--Treatments--Ductal Carcinoma In Situ
    Jennifer Griggs; Fiscal Year: 2004
    ..abstract_text> ..
  26. PRIMARY BREAST CANCER THERAPY GROUP
    Roger Poisson; Fiscal Year: 1980
    ..We have made a major contribution (35 patients) to Protocol No. 6, which is a protocol to compare worth of segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection...
  27. MAMMOGRAPHIC DENSITY AND BREAST CANCER AFTER DCIS
    Laurel Habel; Fiscal Year: 2000
    ..abstract_text> ..
  28. CARE, COSTS AND OUTCOMES OF LOCAL BREAST CANCER
    Jeanne Mandelblatt; Fiscal Year: 1999
    ....
  29. ADJUVANT TAMOXIFEN THERAPY IN OLD AGE
    Rebecca Silliman; Fiscal Year: 1999
    ..The two secondary aims of the research are to compare tamoxifen-treated and untreated women with respect to: 1) the prevalence of symptoms commonly attributed to tamoxifen therapy and 2) health-related quality of life. ..
  30. DCIS--MAMMOGRAPHIC FEATURES AND PROGNOSIS
    Laurel Habel; Fiscal Year: 2003
    ..abstract_text> ..
  31. PRIMARY BREAST CANCER THERAPY GROUP (NSABP)
    David Plotkin; Fiscal Year: 1980
    ..compared the worth of three-drug chemotherapy (L-PAM, 5-FU and Methotrexate) with two-drug chemotherapy segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection...
  32. MBSR for Stress-Related Immune Dysregulation in Cancer
    LINDA JANUSEK; Fiscal Year: 2004
    ..Such an approach has the potential to lead to not only better cancer control but also to a better quality of life for cancer. ..
  33. NURSING THERAPY--ATTENTIONAL FATIQUE IN CANCER PATIENTS
    Bernadine Cimprich; Fiscal Year: 2000
    ..The ultimate aim of the research is to develop a theoretically based, low-cost intervention to restore attention and improve overall functioning in women treated for breast cancer. ..
  34. PRIMARY BREAST CANCER THERAPY GROUP
    CARL SUTHERLAND; Fiscal Year: 1980
    ..We project 5 patients per year by year No. 5 in Protocol No. 6, which is a trial of segmental mastectomy with and without breast irradiation and total mastectomy with axillary dissection...
  35. EVALUATION OF PRACTICE VARIATIONS AND COSTS FOR CANCER
    Sheldon Retchin; Fiscal Year: 1992
    ....
  36. PRIMARY BREAST CANCER THERAPY GROUP--NSABP
    HARVEY LERNER; Fiscal Year: 1991
    ..Protocol No. 6: A trial to compare the worth of segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection...
  37. PRIMARY BREAST CANCER THERAPY GROUP (NSABP)
    HARVEY LERNER; Fiscal Year: 1980
    ..The new protocols are: (1) No. 6: A trial to compare the worth of segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection...
  38. PRIMARY CANCER THERAPY GROUP
    JANET WOLTER; Fiscal Year: 1991
    ..These include segmental mastectomy with or without radiation therapy vs...
  39. PRIMARY BREAST CANCER THERAPY GROUP (NSABP)
    Bernard Fisher; Fiscal Year: 1980
    ..evaluating the relative efficacy of radical and total mastectomy with and without postoperative radiation, segmental mastectomy and a variety of protocols employing chemotherapy in various combinations alone or with the antiestrogen ..
  40. Optical surveillance of tumor margins in patients undergoing breast conserving su
    NIMMI RAMANUJAM; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. USING RESEARCH TO INFORM PATIENTS OF BREAST CANCER SURGE
    Diana Zuckerman; Fiscal Year: 2001
    ..The overall goal of this conference is to help ensure that patients have the information they need to make the surgical decisions that acre best for them...
  42. BREAST CANCER TREATMENT DECISIONS BY CHINESE AMERICANS
    Moira Killoran; Fiscal Year: 2002
    ..In collaboration with an advisory committee, qualitative analyses will inform development of guidelines to promote more effective communication between breast cancer clinicians and their Chinese-American patients. ..
  43. Evaluating the Effectiveness of Lung Cancer Treatment in the Elderly
    Juan Wisnivesky; Fiscal Year: 2009
    ..The findings from this project will provide information that can directly impact the care of elderly patients with NSCLC and inform the design of future trials of lung cancer treatment strategies. ..
  44. PRIMARY CANCER THERAPY GROUP (NSABP)
    E Elias; Fiscal Year: 1980
    ..currently participates in the following protocols: (1) B-06, which is a trial to compare the worth of segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection...
  45. PRIMARY BREAST CANCER THERAPY GROUP (NSABP)
    YOSEF PILCH; Fiscal Year: 1980
    ..The ongoing protocols are: (1) No.6: A trial to compare the worth of segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection...
  46. SURGICAL ADJUVANT PROJECT FOR BREAST AND BOWEL CANCERS
    Philip Breen; Fiscal Year: 1980
    ..with chemotherapy and its relation to estrogen and progesterone receptors (B-09); to test the efficacy of segmental mastectomy, with or without radiation, vs...
  47. DATA SOURCES AND PATTERNS OF CARE FOR BREAST CANCER
    Edward Guadagnoli; Fiscal Year: 1999
    ....
  48. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2006
    ..3) Study 60 patients treated with either the best delivery-optimized motion corrected plan from Aim 2 or PWTF and compare plans using heart and lung metrics. ..
  49. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2003
    ..4) Determine the effect of motion on static IMRT and PWTF dose distributions, and then correct/adjust for motion to determine the best delivery-optimized plan. ..
  50. CANCER EDUCATION PROGRAM
    Julia White; Fiscal Year: 2007
    ..Longitudinal tracking of student participants at a later point in their medical training is done to assess the long-term impact of the research experience on career paths. ..
  51. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  52. Fractures, Heart Disease, and Stroke on Aromatase Inhibitors
    Nancy L Keating; Fiscal Year: 2010
    ....
  53. Managed Care Penetration and Cancer Care
    Nancy Keating; Fiscal Year: 2003
    ..If managed care penetration is negatively associated with the delivery of care, interventions targeted toward policy-makers, providers, and patients will be needed to counteract the effects of market forces. ..
  54. Intra-operative radiographic margin assessment tool for breast-conserving surgery
    EMRE TOKER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Osteoporosis Prevention in Early Stage Breast Cancer
    Dawn Hershman; Fiscal Year: 2006
    ..abstract_text> ..
  56. Local Therapy of Breast Cancer in Community Populations
    Nancy Keating; Fiscal Year: 2007
    ..Moreover, the work will provide insight into different techniques for the analysis of observational data. ..
  57. Market Competition and the Quality of Home Health Services
    DANIEL E POLSKY; Fiscal Year: 2010
    ....
  58. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2003
    ..The possible mediational role of these factors in hypnosis effects will be examined will classic statistical approaches. ..
  59. PREDICTORS OF RELAPSE TO SMOKING IN LUNG CANCER
    Mario Schootman; Fiscal Year: 2005
    ..abstract_text> ..
  60. Gis, multilevel modeling and breast cancer screening
    Mario Schootman; Fiscal Year: 2002
    ..Few studies focusing on breast cancer screening have taken this approach, which we, and others feel is warranted. ..
  61. Primary Hormonal Therapy for DCIS of the Breast
    EUN SIL HWANG; Fiscal Year: 2008
    ..If patients could safely be spared from cancer progression while avoiding the morbidity of surgery and radiation for DCIS, the full benefit of early breast cancer detection could be realized. ..
  62. Multilevel Model of Breast Cancer Follow-up Care
    Mario Schootman; Fiscal Year: 2005
    ..abstract_text> ..