segmental mastectomy

Summary

Summary: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.

Top Publications

  1. ncbi Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:1233-41. 2002
  2. ncbi Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
  3. ncbi Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Semin Oncol 28:400-18. 2001
  4. ncbi Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy
    S Eva Singletary
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 444, Houston TX 77030 4095, USA
    Am J Surg 184:383-93. 2002
  5. ncbi Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial
    Harry Bartelink
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 25:3259-65. 2007
  6. ncbi Role for intraoperative margin assessment in patients undergoing breast-conserving surgery
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Ann Surg Oncol 14:1458-71. 2007
  7. ncbi The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery
    Tara L Huston
    New York Presbyterian Hospital, Cornell University, 425 East 61st Street, 8th Floor, New York, NY 10021, USA
    Am J Surg 192:509-12. 2006
  8. ncbi Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, Division of Pathology, and Breast Committee, Pittsburgh, PA, USA
    J Clin Oncol 20:4141-9. 2002
  9. ncbi Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials
    A C Voogd
    Eindhoven Cancer Registry, The Netherlands Cancer Institute, Eindhoven, The Netherlands
    J Clin Oncol 19:1688-97. 2001
  10. doi Predictors of surgical margin status in breast-conserving surgery within a breast screening program
    Emil D Kurniawan
    Department of Surgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, 3050, Australia
    Ann Surg Oncol 15:2542-9. 2008

Detail Information

Publications231 found, 100 shown here

  1. ncbi Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
    N Engl J Med 347:1233-41. 2002
    ..In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer...
  2. ncbi Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
    ..We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery...
  3. ncbi Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Semin Oncol 28:400-18. 2001
    ..It does suggest, however, that, in the treatment of DCIS, the appropriate use of current and better therapeutic agents that become available could diminish the significance of breast cancer as a public health problem...
  4. ncbi Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy
    S Eva Singletary
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 444, Houston TX 77030 4095, USA
    Am J Surg 184:383-93. 2002
    ..This review examines published reports about standard and innovative approaches to assessing surgical margins, the clinical significance of margin size, and risk factors for positive margins...
  5. ncbi Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial
    Harry Bartelink
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 25:3259-65. 2007
    ..To investigate the long-term impact of a boost radiation dose of 16 Gy on local control, fibrosis, and overall survival for patients with stage I and II breast cancer who underwent breast-conserving therapy...
  6. ncbi Role for intraoperative margin assessment in patients undergoing breast-conserving surgery
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Ann Surg Oncol 14:1458-71. 2007
    ..We investigated whether intraoperative margin assessment aids in obtaining negative margins, and to evaluate the local control thus achieved...
  7. ncbi The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery
    Tara L Huston
    New York Presbyterian Hospital, Cornell University, 425 East 61st Street, 8th Floor, New York, NY 10021, USA
    Am J Surg 192:509-12. 2006
    ....
  8. ncbi Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less
    Bernard Fisher
    National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, Division of Pathology, and Breast Committee, Pittsburgh, PA, USA
    J Clin Oncol 20:4141-9. 2002
    ....
  9. ncbi Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials
    A C Voogd
    Eindhoven Cancer Registry, The Netherlands Cancer Institute, Eindhoven, The Netherlands
    J Clin Oncol 19:1688-97. 2001
    ..Risk factors for local and distant recurrence after breast-conserving therapy and mastectomy were compared to define guidelines for the decision making between both treatments...
  10. doi Predictors of surgical margin status in breast-conserving surgery within a breast screening program
    Emil D Kurniawan
    Department of Surgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, 3050, Australia
    Ann Surg Oncol 15:2542-9. 2008
    ..We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at the first operation...
  11. pmc Locoregional recurrence of triple-negative breast cancer after breast-conserving surgery and radiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer 115:946-51. 2009
    ..The results of radiation on the local control of triple receptor-negative breast cancer (negative estrogen [ER], progesterone [PR], and HER-2/neu receptors) was studied...
  12. pmc Intraoperative ultrasound is associated with clear lumpectomy margins for palpable infiltrating ductal breast cancer
    M M Moore
    Martha Jefferson Physician Hospital Organization, Charlottesville, Virginia 22903, USA
    Ann Surg 233:761-8. 2001
    ..To evaluate the efficacy of intraoperative ultrasound in obtaining adequate surgical margins in women undergoing lumpectomy for palpable breast cancer...
  13. pmc The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial
    S M Bentzen
    Lancet Oncol 9:331-41. 2008
    ..We tested two dose levels of a 13-fraction schedule against the standard regimen with the aim of measuring the sensitivity of normal and malignant tissues to fraction size...
  14. doi Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 26:2373-8. 2008
    ..To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy...
  15. ncbi Accelerated partial breast irradiation as a part of breast conservation therapy
    Douglas W Arthur
    Radiation Oncology Department, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA
    J Clin Oncol 23:1726-35. 2005
  16. ncbi The frequency of ipsilateral second tumors after breast-conserving surgery for DCIS: a population based analysis
    Joan L Warren
    Health Services and Economics Branch Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7344, USA
    Cancer 104:1840-8. 2005
    ..This analysis of women treated with breast-conserving surgery (BCS) evaluated the impact of radiation therapy (RT) in patient outcomes...
  17. ncbi Prospective study of wide excision alone for ductal carcinoma in situ of the breast
    Julia S Wong
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:1031-6. 2006
    ..It has been hypothesized that wide excision alone with margins > or = 1 cm may be adequate treatment for small, grade 1 or 2 ductal carcinoma in situ (DCIS). To test this hypothesis, we conducted a prospective, single-arm trial...
  18. ncbi Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy
    Dorothee Twardella
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Radiother Oncol 69:145-53. 2003
    ..The influence of therapy modalities, personal characteristics and individual DNA repair capacity on the risk of acute skin toxicity was thus evaluated...
  19. ncbi Influence of breast cancer margin assessment method on the rates of positive margins and residual carcinoma
    Jane E Mendez
    Department of Surgery, Boston Medical Center, Boston University School of Medicine, 88 E Newton St, D 509, Boston, MA 02118, USA
    Am J Surg 192:538-40. 2006
    ..We hypothesized that the method of breast cancer margin assessment may be associated with different rates of positive margins and residual carcinoma...
  20. ncbi Long-term survival outcomes following breast cancer surgery in Western Australia
    Katrina Spilsbury
    Western Australian Safety and Quality of Surgical Care Project, Centre for Health Services Research, School of Population Health, University of Western Australia, Crawley, Australia
    ANZ J Surg 75:625-30. 2005
    ..The aim of the present study was to investigate how hospital, social and demographic factors were associated with survival outcomes from surgically treated breast cancer for all women living in Western Australia...
  21. ncbi Fibrin sealant reduces the duration and amount of fluid drainage after axillary dissection: a randomized prospective clinical trial
    M Moore
    Department of Surgery and the Tissue Adhesive Center, University of Virginia, Charlottesville, USA
    J Am Coll Surg 192:591-9. 2001
    ..The viral safety of the product was also supported...
  22. ncbi Breast conservation after neoadjuvant chemotherapy: the MD Anderson cancer center experience
    Allen M Chen
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 22:2303-12. 2004
    ..To determine patterns of local-regional recurrence (LRR) and ipsilateral breast tumor recurrence (IBTR) among patients treated with breast conservation therapy after neoadjuvant chemotherapy...
  23. ncbi Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer
    Kevin S Hughes
    Avon Comprehensive Breast Evaluation Center, Breast Ovarian Cancer Genetics and Risk Assessment Program, Massachusetts General Hospital, Division of Surgical Oncology, Boston 02114, USA
    N Engl J Med 351:971-7. 2004
    ..In women 70 years of age or older who have early breast cancer, it is unclear whether lumpectomy plus tamoxifen is as effective as lumpectomy followed by tamoxifen plus radiation therapy...
  24. pmc Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial
    Heather A Jones
    Department of Radiation Oncology, University of Pittsburgh Cancer Center, Pittsburgh, PA, USA
    J Clin Oncol 27:4939-47. 2009
    ..To investigate the long-term impact of pathologic characteristics and an extra boost dose of 16 Gy on local relapse, for stage I and II invasive breast cancer patients treated with breast conserving therapy (BCT)...
  25. doi The surgical margin status after breast-conserving surgery: discussion of an open issue
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 113:397-402. 2009
    ..Radiation therapy could be a good option in the management of these cases, but further evidence is needed to establish the real impact of clear surgical margins on local control of disease and, furthermore, on survival...
  26. doi Factors correlating with reexcision after breast-conserving therapy
    M R Bani
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Erlangen, Germany
    Eur J Surg Oncol 35:32-7. 2009
    ..Several factors, including tumor size, multifocality, and an extensive in situ component, may be associated with a higher rate of repeat operations due to positive margins. This study included mammographic density in the analysis...
  27. doi A prospective, randomized, controlled, multicenter study of a real-time, intraoperative probe for positive margin detection in breast-conserving surgery
    Tanir M Allweis
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Surg 196:483-9. 2008
    ....
  28. ncbi Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality
    Vincent Vinh-Hung
    Oncology Center, Academic Hospital, Vrije Universiteit Brussel, Jette, Belgium
    J Natl Cancer Inst 96:115-21. 2004
    ..The objective of the study was to investigate whether radiotherapy or its omission after breast-conserving surgery has measurable consequences on local tumor growth and patient survival...
  29. ncbi A comparison of ink-directed and traditional whole-cavity re-excision for breast lumpectomy specimens with positive margins
    G R Gibson
    Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Ann Surg Oncol 8:693-704. 2001
    ....
  30. pmc Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey
    Alphonse Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Cox 302, 100 Blossom Street, Boston, MA 02114, USA
    Ann Surg 241:629-39. 2005
    ....
  31. ncbi Intraoperative margin assessment and re-excision rate in breast conserving surgery
    F J Fleming
    Department of Surgery, St Vincent s University Hospital, University College Dublin, Elm Park, Dublin 4, Ireland
    Eur J Surg Oncol 30:233-7. 2004
    ..The aim of this study was to assess the efficacy of intraoperative margin assessment in obtaining clear margins in conserving surgery for breast cancer...
  32. pmc Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study
    Christine B Ambrosone
    Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 8:R40. 2006
    ..We hypothesized that polymorphisms encoding reduced or absent activity in the GSTs might result in greater risk for radiation-associated toxicity...
  33. ncbi Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy
    Martin Keisch
    Department of Radiation Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Int J Radiat Oncol Biol Phys 55:289-93. 2003
    ..We present the results of the initial clinical testing of the MammoSite balloon breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy...
  34. ncbi Importance of lymphatic mapping in ductal carcinoma in situ (DCIS): why map DCIS?
    C E Cox
    Department of Surgery, University of South Florida College of Medicine, Tampa, USA
    Am Surg 67:513-9; discussion 519-21. 2001
    ..No "high-risk" group of patients can be identified for selective sentinel lymph node biopsy...
  35. ncbi Predictors of reexcision findings and recurrence after breast conservation
    Melanie C Smitt
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 57:979-85. 2003
    ..To identify predictors of reexcision findings and local recurrence in the setting of breast-conserving therapy with radiation...
  36. ncbi Breast carcinomas of limited extent: frequency, radiologic-pathologic characteristics, and surgical margin requirements
    D R Faverly
    Department of Pathology, Radboud University Hospital, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer 91:647-59. 2001
    ..The mammographic and pathologic criteria for the identification of tumors with limited extent are not yet established; furthermore, the optimal extent of the surgical excision and the method for margin examination are controversial...
  37. doi Prevalence and predictive factors for the detection of carcinoma in cavity margin performed at the time of breast lumpectomy
    Iulia Tengher-Barna
    Service d Anatomie et de Cytologie Pathologiques, CHU Jean Verdier AP HP, Bondy, France
    Mod Pathol 22:299-305. 2009
    ..Our study confirms that the systematic practice of cavity margin resection avoids surgical re-excision and reduces the likelihood of underestimating the extent of the tumor...
  38. doi Importance of routine cavity sampling in breast conservation surgery
    J C Hewes
    The Breast Unit, William Harvey Hospital, Kennington Road, Willesborough, Kent, UK
    Br J Surg 96:47-53. 2009
    ..This study compared four groups of patients to determine the significance of margins and CB histology on tumour characteristics and outcome...
  39. doi The impact of preoperative MRI on breast-conserving surgery of invasive cancer: a comparative cohort study
    K E Pengel
    Department of Radiology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital NKI AVL, Amsterdam, The Netherlands
    Breast Cancer Res Treat 116:161-9. 2009
    ..To assess whether preoperative contrast-enhanced magnetic resonance imaging (MRI) of the breast influences the rate of incomplete tumor excision...
  40. ncbi Accelerated treatment of breast cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 19:1993-2001. 2001
    ..The goals of the study were to determine whether treatment time can be reduced and whether elective treatment of the entire breast is necessary...
  41. pmc Impact of preoperative versus postoperative chemotherapy on the extent and number of surgical procedures in patients treated in randomized clinical trials for breast cancer
    Judy C Boughey
    Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 244:464-70. 2006
    ..To determine the effect of preoperative chemotherapy on the volume of tissue excised and the number of breast operations in patients undergoing breast-conserving therapy (BCT)...
  42. ncbi Risk factors for local recurrence in patients with invasive breast cancer and negative surgical margins of excision. Where are we and where are we going?
    Stuart J Schnitt
    Am J Clin Pathol 120:485-8. 2003
  43. ncbi Ductal carcinoma in situ, complexities and challenges
    Gregory D Leonard
    Cancer Therapeutics Branch, National Cancer Institute, Bethesda, MD 20889 5105, USA
    J Natl Cancer Inst 96:906-20. 2004
    ..Ongoing and recently completed studies should provide information on outcomes in patients treated with lumpectomy alone and on the effectiveness of aromatase inhibitors as an alternative to tamoxifen...
  44. ncbi Patterns of breast recurrence in a pilot study of brachytherapy confined to the lumpectomy site for early breast cancer with six years' minimum follow-up
    Francisco Perera
    Department of Radiation Oncology, London Regional Cancer Centre, London, Ontario, Canada
    Int J Radiat Oncol Biol Phys 57:1239-46. 2003
    ....
  45. pmc Indicators of breast cancer severity and appropriateness of surgery based on hospital administrative data in the Lazio Region, Italy
    Patrizia Schifano
    Department of Epidemiology, Health Local Unit RME, Rome, Italy
    BMC Public Health 6:25. 2006
    ..The aim of this study is to evaluate the use of hospital administrative data to determine breast cancer severity and the appropriateness of surgical treatment...
  46. ncbi Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial
    U Veronesi
    Department of Senology, European Institute of Oncology, Milano, Italy
    Ann Oncol 12:997-1003. 2001
    ..Breast-conserving surgery followed by radiotherapy is a widely accepted form of treatment in patients with breast cancer of limited extent. Many attempts have been made to identify subgroups of patients who might avoid radiotherapy...
  47. ncbi Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 55:1216-25. 2003
    ..The study objective was to evaluate whether DNA repair data determined in vitro are correlated with the occurrence of acute side effects during radiotherapy...
  48. pmc Oncoplastic techniques allow extensive resections for breast-conserving therapy of breast carcinomas
    Krishna B Clough
    Department of General and Breast Surgery, Institut Curie, Paris, France
    Ann Surg 237:26-34. 2003
    ..To assess the oncologic and cosmetic outcomes in women with breast carcinoma who were treated with breast-conserving therapy using oncoplastic techniques with concomitant symmetrization of the contralateral breast...
  49. ncbi Intra-operative sonography: a valuable aid during breast-conserving surgery for occult breast cancer
    Anton Haid
    Department of General and Thoracic Surgery, Landeskrankenhaus Feldkirch, Teaching Hospital of Innsbruck University, Carinagasse 47 49, 6800, Feldkirch, Austria
    Ann Surg Oncol 14:3090-101. 2007
    ..Together with pre-operative marking of the mass, intra-operative imaging provides invaluable clues. This study was designed to evaluate the usefulness of intra-operative sonography in the hands of the surgeon...
  50. ncbi Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a phase I-II study and initial findings of a randomized phase III trial
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    J Surg Oncol 80:121-8; discussion 129. 2002
    ....
  51. ncbi Target volume delineation for partial breast radiotherapy planning: clinical characteristics associated with low interobserver concordance
    Ross P Petersen
    Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, Victoria, Canada
    Int J Radiat Oncol Biol Phys 69:41-8. 2007
    ..To examine variability in target volume delineation for partial breast radiotherapy planning and evaluate characteristics associated with low interobserver concordance...
  52. ncbi Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast
    Lawrence J Solin
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer 103:1137-46. 2005
    ..The objective of the current study was to determine the long-term outcome after breast-conservation surgery followed by definitive breast irradiation for women with mammographically detected DCIS of the breast...
  53. ncbi Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence
    T P Olson
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Ann Surg Oncol 14:2953-60. 2007
    ..We retrospectively analyzed records of patients who received breast-conserving therapy with intraoperative FSA of the lumpectomy cavity to assess re-excision rates and local control...
  54. ncbi Relationship between excision volume, margin status, and tumor size with the development of local recurrence in patients with ductal carcinoma-in-situ treated with breast-conserving therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Surg Oncol 76:245-54. 2001
    ....
  55. ncbi Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation
    H Bartelink
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam
    N Engl J Med 345:1378-87. 2001
    ..We evaluated the effect of a supplementary dose of radiation to the tumor bed on the rates of local recurrence among patients who received radiotherapy after breast-conserving surgery for early breast cancer...
  56. ncbi Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy
    U Veronesi
    Division of Senology, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
    Ann Oncol 16:383-8. 2005
    ..The aim of the study was to assess the role of axillary radiotherapy (RT) in reducing axillary metastases in patients with early breast cancer who did not receive axillary dissection...
  57. ncbi Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins
    Juan C Cendan
    Department of Surgery, University of Florida, College of Medicine, Gainesville, FL 32610 0286, USA
    J Am Coll Surg 201:194-8. 2005
    ..We review our experience in breast-conservation therapy (BCT) at the University of Florida (Gainesville) to determine the effectiveness of this approach...
  58. ncbi Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy
    Funda Meric
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 97:926-33. 2003
    ....
  59. ncbi Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
    Lancet 353:1993-2000. 1999
    ..We did a double-blind randomised controlled trial to find out whether lumpectomy, radiation therapy, and tamoxifen was of more benefit than lumpectomy and radiation therapy alone for DCIS...
  60. ncbi Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853--a study by the EORTC Breast Cancer Cooperative Group and
    Nina Bijker
    Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 24:3381-7. 2006
    ..We analyzed the efficacy of RT with 10 years follow-up on both the overall risk of local recurrence (LR) and related to clinical, histologic, and treatment factors...
  61. ncbi Limited-field radiation therapy in the management of early-stage breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    J Natl Cancer Inst 95:1205-10. 2003
    ..e., limited-field radiation therapy) in selected patients treated with breast-conserving therapy and compared them with results of matched breast-conserving therapy patients who underwent whole-breast radiation therapy...
  62. ncbi Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial
    Joan Houghton
    Clinical Trials Group, Department of Surgery, Royal Free and University College Medical School, Charles Bell House, London W1W 7EJ, UK
    Lancet 362:95-102. 2003
    ..We aimed to assess the effectiveness of adjuvant radiotherapy and tamoxifen...
  63. ncbi Gene expression profiles of primary breast carcinomas from patients at high risk for local recurrence after breast-conserving therapy
    Bas Kreike
    Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Clin Cancer Res 12:5705-12. 2006
    ..We used cDNA microarray analysis to identify gene expression profiles associated with local recurrence...
  64. ncbi Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma--5-year results of a randomized trial
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    Int J Radiat Oncol Biol Phys 69:694-702. 2007
    ..To report the 5-year results of a randomized study comparing the survival and cosmetic results of breast-conserving treatment with partial breast irradiation (PBI) or conventional whole breast irradiation (WBI)...
  65. doi Do additional shaved margins at the time of lumpectomy eliminate the need for re-excision?
    Allyson F Jacobson
    Department of General Surgery, Division of Breast Surgery, Beth Israel Medical Center, 10 Union Square East, Ste 4E, New York, NY 10003, USA
    Am J Surg 196:556-8. 2008
    ..Re-excision rates for positive margins have been reported to be greater than 50%. The purpose of our study was to determine if removing additional shaved margins from the lumpectomy cavity at the time of lumpectomy reduces re-excisions...
  66. ncbi Female patients with breast carcinoma age 30 years and younger have a poor prognosis: the M.D. Anderson Cancer Center experience
    Q Xiong
    Division of Cancer Medicine; University of Texas M. D. Anderson Cancer Center; Houston, Texas 77030, USA
    Cancer 92:2523-8. 2001
    ..CONCLUSIONS: Women who are diagnosed with breast carcinoma at an age < or = 30 years appear to have a poorer prognosis compared with that for their older counterparts...
  67. ncbi Persistent differences in sociodemographic determinants of breast conserving treatment despite overall increased adoption
    Mary Ann Gilligan
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Med Care 40:181-9. 2002
    ..Use of breast-conserving treatment (BCT) has previously demonstrated variability by sociodemographic factors...
  68. ncbi Is excision alone adequate treatment for low-risk ductal carcinoma-in-situ of the breast?
    Lawrence J Solin
    J Clin Oncol 24:1017-9. 2006
  69. ncbi Accelerated partial breast irradiation: a change in treatment paradigm for early stage breast cancer
    Douglas Arthur
    J Surg Oncol 84:185-91. 2003
  70. pmc A randomized trial comparing axillary dissection to no axillary dissection in older patients with T1N0 breast cancer: results after 5 years of follow-up
    Gabriele Martelli
    Unit of Diagnostic Oncology and Out Patient Clinic, Istituto Nazionale Tumori, Milan, Italy
    Ann Surg 242:1-6; discussion 7-9. 2005
    ..We addressed this issue in a randomized trial comparing axillary dissection with no axillary dissection in older patients with T1N0 breast cancer...
  71. ncbi Analysis of ipsilateral breast tumor recurrences after breast-conserving treatment based on the classification of true recurrences and new primary tumors
    Yoshifumi Komoike
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Breast Cancer 12:104-11. 2005
    ..The aim of this study is to clarify the biological difference between TR and NP, and to show the clinical significance of classifying IBTR into these two types of recurrence...
  72. ncbi A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer
    Nicole Hébert-Croteau
    Direction des Systèmes de Soins et Services, Institut National de Sante Publique du Quebec, Canada
    Breast Cancer Res Treat 88:187-96. 2004
    ..Practice guidelines have set a maximum waiting time to radiation therapy for breast cancer. We evaluated if delaying radiotherapy resulted in worse outcomes in a large cohort of women with node-negative breast cancer...
  73. ncbi Separate cavity margin sampling at the time of initial breast lumpectomy significantly reduces the need for reexcisions
    Dengfeng Cao
    Departments of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:1625-32. 2005
    ....
  74. ncbi The Salzburg concept of intraoperative radiotherapy for breast cancer: results and considerations
    Roland Reitsamer
    Breast Center Salzburg, University Hospital Salzburg, Paracelsus Private Medical School Salzburg, Salzburg, Austria
    Int J Cancer 118:2882-7. 2006
    ....
  75. ncbi Doxorubicin with cyclophosphamide followed by docetaxel every 21 days compared with doxorubicin and docetaxel every 14 days as preoperative treatment in operable breast cancer: the GEPARDUO study of the German Breast Group
    Gunter von Minckwitz
    German Breast Group, Neu Isenburg Frankfurt, Germany
    J Clin Oncol 23:2676-85. 2005
    ..Dose-dense and sequential administration of cytotoxic drugs are current approaches to improve outcomes in patients with early-stage breast cancer...
  76. ncbi Role of breast reconstructive surgery in physical and emotional outcomes among breast cancer survivors
    J H Rowland
    Office of Cancer Survivorship, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 92:1422-9. 2000
    ..To address some of these issues, we examined women's adaptation to surgery in two large cohorts of breast cancer survivors...
  77. ncbi Definition of postlumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips
    Hadassah Goldberg
    Department of Oncology, Rambam Medical Center, Haifa, Israel
    Int J Radiat Oncol Biol Phys 63:209-13. 2005
    ..To compare the location and extent of the tumor bed as defined by surgical clips and computed tomography (CT) scans, after lumpectomy, for electron boost planning as part of breast radiotherapy...
  78. ncbi Breast-conserving therapy in breast cancer patients--a 12-year experience
    Aylwyn Mannell
    Department of Surgery, University of the Witwatersrand, and Linksfield Park and Park Lane Clinics, Johannesburg
    S Afr J Surg 43:28-30; discussion 30, 32. 2005
    ..The results have shown no survival advantage for mastectomy over breast-conserving therapy (BCT). However, local recurrence of cancer after BCT has been reported to be as high as 14%, necessitating salvage mastectomy...
  79. ncbi Positive margins following surgical resection of breast carcinoma: analysis of pathologic correlates
    Alexander R Miller
    Division of Surgical Oncology, Cancer Therapy and Research Center, San Antonio, Texas 78229 3900, USA
    J Surg Oncol 86:134-40. 2004
    ....
  80. ncbi High hospital volume is associated with better outcomes for breast cancer surgery: analysis of 233,247 patients
    Ulrich Guller
    Department of Surgery, Division of General Surgery, University of Basel, Spitalstrasse 21, CH 4031, Basel, Switzerland
    World J Surg 29:994-9; discussion 999-1000. 2005
    ..The objective of this investigation was to assess the relationship between hospital volume and outcomes for breast cancer surgery...
  81. ncbi The influence of margin width on local control of ductal carcinoma in situ of the breast
    M J Silverstein
    Department of Surgery, University of Southern California School of Medicine, and the Harold E and Henrietta C Lee Breast Center of the Kenneth Norris Jr Comprehensive Cancer Center, Los Angeles 90033, USA
    N Engl J Med 340:1455-61. 1999
    ..Margin width, the distance between the boundary of the lesion and the edge of the excised specimen, may be an important determinant of local recurrence...
  82. ncbi Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence
    C C Park
    Joint Center for Radiation Therapy, Boston, MA 02215, USA
    J Clin Oncol 18:1668-75. 2000
    ..To examine the relationship between pathologic margin status and outcome at 8 years after breast-conserving surgery and radiation therapy...
  83. ncbi Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 64:1092-9. 2006
    ..Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT)...
  84. ncbi Should all patients undergoing breast conserving therapy for DCIS receive radiation therapy? No. One size does not fit all: an argument against the routine use of radiation therapy for all patients with ductal carcinoma in situ of the breast who elect bre
    Melvin J Silverstein
    J Surg Oncol 95:605-9. 2007
  85. ncbi Intraoperative touch preparation cytology for margin assessment in breast-conservation surgery: does it work for lobular carcinoma?
    Edna K Valdes
    Department of Surgery, Louis Venet Comprehensive Breast Service, Beth Israel Medical Center, New York, New York 10003, USA
    Ann Surg Oncol 14:2940-5. 2007
    ..This report describes our experience with IOTPC for margin assessment in ILC by a single surgeon at Beth Israel Medical Center. The purpose of this study is to determine whether IOTPC is reliable for ILC...
  86. ncbi Do changes in surgical procedures for breast cancer have consequences for hospital mean length of stay? A study of women operated on for breast cancer in Sweden, 1980-95
    Rikard Lindqvist
    Lunds University Hospital, Sweden
    Int J Technol Assess Health Care 18:566-75. 2002
    ..Between 1986 and 1996, the overall mean overnight length of stay for all diagnoses in Sweden decreased from 20.8 to 7.1 days...
  87. ncbi Association of clinical and pathologic variables with lumpectomy surgical margin status after preoperative diagnosis or excisional biopsy of invasive breast cancer
    Melanie C Smitt
    Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Dr, Stanford, CA 94305, USA
    Ann Surg Oncol 14:1040-4. 2007
    ..To evaluate the impact of preoperative diagnosis in obtaining negative lumpectomy margins...
  88. ncbi Letrozole as primary medical therapy for locally advanced and large operable breast cancer
    J M Dixon
    Edinburgh Breast Unit, Western General Hospital
    Breast Cancer Res Treat 66:191-9. 2001
    ..To investigate the efficacy of letrozole 2.5 mg and 10 mg used as primary neoadjuvant therapy for patients with locally advanced and large operable breast cancer...
  89. ncbi Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881-10882
    Ninja Antonini
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 82:265-71. 2007
    ..To determine whether the effect of an additional "boost" radiation after breast conservative therapy (BCT) on local control depends on age and evaluate the impact of a treatment policy with a threshold for age...
  90. ncbi Breast electron boost planning: comparison of CT and US
    M C Smitt
    Department of Radiation Oncology, Stanford Hospital, Stanford University Medical Center, 300 Pasteur Dr, Stanford, CA 94305, USA
    Radiology 219:203-6. 2001
    ..To compare computed tomography (CT) with ultrasonography (US) for depiction of the biopsy cavity...
  91. ncbi Significance of margins of excision on breast cancer recurrence
    Gregory P Swanson
    Department of Radiation Oncology, Scott and White Hospital, 2401 South 31st Street, Temple, TX 76508, USA
    Am J Clin Oncol 25:438-41. 2002
    ..Routine reexcision of patients with positive margins does not significantly increase the chance of local control in patients who receive breast irradiation...
  92. ncbi The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: How young is "young"?
    Julia L Oh
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 65:1345-52. 2006
    ..The aim of this study was to investigate whether patients <35 years old have similar risk of locoregional recurrence after breast conservation therapy compared with patients 35 to 40 years old...
  93. ncbi Recurrence of breast cancer following local excision alone for ductal carcinoma in situ
    J Horiguchi
    Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
    Breast Cancer 8:52-7. 2001
    ..Either wide excision with a larger free margin or adjuvant radiation therapy following duct-lobular segmentectomy should be considered for these patients...
  94. ncbi The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer
    Dalal Aziz
    Department of Surgery and Biostatistics, Centre for Research in Women s Health, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Breast J 12:331-7. 2006
    ..Reexcision to clear involved margins is an important surgical intervention for both younger and older women...
  95. ncbi Factors influencing choice between mastectomy and lumpectomy for women in the Carolinas
    S Benedict
    College of Nursing, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Surg Oncol 76:6-12. 2001
    ..The Carolinas have been documented to have a low rate of breast-conserving surgery. The purpose of this study was to determine factors that influence women's choice between mastectomy and lumpectomy...
  96. ncbi Examining the use of breast-conserving treatment for women with breast cancer in a managed care environment
    A P Legorreta
    Health Benchmarks, Inc, Woodland Hills, CA 91367, USA
    Am J Clin Oncol 23:438-41. 2000
    ..This treatment became available in a broader range of institutions, moving from large, academic teaching centers to smaller community hospitals...
  97. ncbi Prospective randomized study comparing cryo-assisted and needle-wire localization of ultrasound-visible breast tumors
    Lorraine Tafra
    Anne Arundel Medical Center, 2002 Medical Pkwy, Suite 120, Annapolis, MD 21401, USA
    Am J Surg 192:462-70. 2006
    ..This study compared the surgical results of 2 localization methods-cryo-assisted localization (CAL) and needle-wire localization (NWL)-in patients undergoing breast lumpectomy for breast cancer...
  98. ncbi Needle core biopsy characteristics identify patients at risk of compromised margins in breast conservation surgery
    Mary F Dillon
    Department of Surgery, St Vincent s University Hospital, Dublin, Ireland
    Mod Pathol 21:39-45. 2008
    ..Documentation of these parameters may assist patient selection for breast-conserving surgery or identify patients who may benefit from wider margins at the time of initial operation...
  99. doi Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group ba
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    Radiother Oncol 94:264-73. 2010
    ..To give recommendations on patient selection criteria for the use of accelerated partial-breast irradiation (APBI) based on available clinical evidence complemented by expert opinion...
  100. doi A multi-site validation trial of radioactive seed localization as an alternative to wire localization
    Jenevieve H Hughes
    Department of Surgery, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Breast J 14:153-7. 2008
    ..015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re-excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL...
  101. ncbi Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer
    K Wasser
    Department of Radiology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
    Eur Radiol 17:1865-74. 2007
    ..There is no evidence that the interpretation of findings is complicated after IORT...

Research Grants75

  1. Managed Care Penetration and Cancer Care
    Nancy Keating; Fiscal Year: 2003
    ..If managed care penetration is negatively associated with the delivery of care, interventions targeted toward policy-makers, providers, and patients will be needed to counteract the effects of market forces. ..
  2. Managed Care Penetration and Cancer Care
    Edward Guadagnoli; Fiscal Year: 2002
    ..If managed care penetration is negatively associated with the delivery of care, interventions targeted toward policy-makers, providers, and patients will be needed to counteract the effects of market forces. ..
  3. Beta Camera and Laparoscopic Probe for Surgical Cancer Removal.
    FARHAD DAGHIGHIAN; Fiscal Year: 2007
    ....
  4. Long-term Survivorship in Older Women with Early Stage Breast Cancer
    Rebecca A Silliman; Fiscal Year: 2010
    ....
  5. Long-term Survivorship in Older Women with Early Stage Breast Cancer
    Rebecca Silliman; Fiscal Year: 2009
    ....
  6. Surgical Site and Clostridium difficile Infections after Ambulatory Surgery
    Margaret A Olsen; Fiscal Year: 2010
    ..This study will provide important new information that can be used to improve outcomes after common surgical procedures. ..
  7. Breast Cancer Treatment Effectiveness in Older Women
    Rebecca Silliman; Fiscal Year: 2006
    ..Findings from this study will inform clinical practice, particularly the care of older women with co-morbidities who are unlikely to participate in clinical trials. ..
  8. Developing a Tool to Improve the Quality of Breast Cancer Treatment Decisions
    Sarah Hawley; Fiscal Year: 2007
    ..This project has direct relevance for improving the quality of cancer care for all women. ..
  9. Decision-making regarding radiation therapy in breast cancer"
    RINAA PUNGLIA; Fiscal Year: 2007
    ..The proposed combined education and research program, in addition to strong mentorship, will provide the candidate with the skills and experience necessary for a career as an independent outcomes researcher in breast cancer. ..
  10. Novel Biomarkers for Aromatase Inhibitor Therapy
    Matthew Ellis; Fiscal Year: 2007
    ..abstract_text> ..
  11. Cost-Effectiveness--Treatments--Ductal Carcinoma In Situ
    Andrew Dick; Fiscal Year: 2003
    ..abstract_text> ..
  12. Cost-Effectiveness--Treatments--Ductal Carcinoma In Situ
    Jennifer Griggs; Fiscal Year: 2004
    ..abstract_text> ..
  13. MBSR for Stress-Related Immune Dysregulation in Cancer
    LINDA JANUSEK; Fiscal Year: 2004
    ..Such an approach has the potential to lead to not only better cancer control but also to a better quality of life for cancer. ..
  14. Statistical Methods in Cancer Control and Epidemiology
    Bradley Carlin; Fiscal Year: 2009
    ....
  15. Statistical Methods in Cancer Control and Epidemiology
    Bradley P Carlin; Fiscal Year: 2010
    ....
  16. DCIS--MAMMOGRAPHIC FEATURES AND PROGNOSIS
    Laurel Habel; Fiscal Year: 2003
    ..abstract_text> ..