islets of langerhans transplantation

Summary

Summary: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.

Top Publications

  1. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
  2. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
  3. pmc Improvement in outcomes of clinical islet transplantation: 1999-2010
    Franca B Barton
    The EMMES Corporation, Rockville, MD, USA
    Diabetes Care 35:1436-45. 2012
  4. ncbi State of the art of clinical islet transplantation and novel protocols of immunosuppression
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB T6G 2C8, Canada
    Curr Diab Rep 11:345-54. 2011
  5. ncbi Five-year follow-up after clinical islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, 2000 College Plaza, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 54:2060-9. 2005
  6. pmc Primary graft function, metabolic control, and graft survival after islet transplantation
    Marie Christine Vantyghem
    University Lille Nord de France, Lille, France
    Diabetes Care 32:1473-8. 2009
  7. ncbi Clinical xenotransplantation: the next medical revolution?
    Burcin Ekser
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Lancet 379:672-83. 2012
  8. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010
  9. pmc Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes
    M D Bellin
    The Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 12:1576-83. 2012
  10. pmc Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization
    Johanna Henriksnäs
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 61:665-73. 2012

Detail Information

Publications359 found, 100 shown here

  1. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
    ..We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol)...
  2. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
    ..Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year...
  3. pmc Improvement in outcomes of clinical islet transplantation: 1999-2010
    Franca B Barton
    The EMMES Corporation, Rockville, MD, USA
    Diabetes Care 35:1436-45. 2012
    ..To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010...
  4. ncbi State of the art of clinical islet transplantation and novel protocols of immunosuppression
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB T6G 2C8, Canada
    Curr Diab Rep 11:345-54. 2011
    ..We review the current status of islet transplantation, and discuss current and future immunosuppressive protocols that will pave the way to more broad application of cellular replacement in diabetes...
  5. ncbi Five-year follow-up after clinical islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, 2000 College Plaza, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 54:2060-9. 2005
    ..The results, though promising, still point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression...
  6. pmc Primary graft function, metabolic control, and graft survival after islet transplantation
    Marie Christine Vantyghem
    University Lille Nord de France, Lille, France
    Diabetes Care 32:1473-8. 2009
    ..CONCLUSIONS Optimal PGF was associated with prolonged graft survival and better metabolic control after islet transplantation. This early outcome may represent a valuable end point in future clinical trials...
  7. ncbi Clinical xenotransplantation: the next medical revolution?
    Burcin Ekser
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Lancet 379:672-83. 2012
    ..Risk of transfer of an infectious microorganism to the recipient is small...
  8. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010
    ....
  9. pmc Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes
    M D Bellin
    The Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 12:1576-83. 2012
    ..03), regardless of maintenance immunosuppression or other factors. These findings support potential for long-term insulin independence after ITA using potent induction therapy, with anti-CD3 Ab or TCDAb+TNF-α-i...
  10. pmc Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization
    Johanna Henriksnäs
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 61:665-73. 2012
    ..Since donor endothelial cells do not expand posttransplantation, disruption of islet integrity is necessary for revascularization to occur by recipient blood vessels...
  11. ncbi Rat islet cell aggregates are superior to islets for transplantation in microcapsules
    E S O'Sullivan
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetologia 53:937-45. 2010
    ..Small islet cell aggregates were studied to determine if their survival and function were superior to intact islets within microcapsules because of reduced oxygen transport limitation and inflammatory mediators...
  12. ncbi Strategic opportunities in clinical islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, Canada
    Transplantation 79:1304-7. 2005
    ..Future opportunities to expand the donor pool using living donor islet transplantation are within reach, and will be enhanced considerably with both donor and recipient adjunctive treatment using islet-specific growth-factors...
  13. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  14. ncbi Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
    Shaoping Deng
    Department of Surgery, Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes 53:624-32. 2004
    ..These results provide direct evidence for abnormalities in the islets of type 2 diabetic patients that may contribute to the pathogenesis of the disease...
  15. ncbi Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology, and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:1438-45. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) are known to produce vascular endothelial growth factor. We hypothesize that co-transplantation of MSCs and islets promotes revascularization and improves islet graft function...
  16. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  17. ncbi Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts
    Neal R Barshes
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin, Suite 1628, Houston, TX 77030, USA
    J Leukoc Biol 77:587-97. 2005
    ....
  18. ncbi Interventional strategies to prevent beta-cell apoptosis in islet transplantation
    Juliet A Emamaullee
    Surgical Medical Research Institute, University of Alberta, Edmonton, AB T6G 2N8
    Diabetes 55:1907-14. 2006
    ..In addition, XIAP has enhanced long-term murine islet allograft survival. The complexities of both intrinsic and extrinsic apoptotic pathway inhibition are discussed in depth...
  19. ncbi Histologic graft assessment after clinical islet transplantation
    Christian Toso
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    Transplantation 88:1286-93. 2009
    ..An accurate monitoring would help understanding the fate of islet grafts after transplantation...
  20. ncbi Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model
    Torsten Eich
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, University Hospital, Uppsala, Sweden
    Transplantation 84:893-8. 2007
    ..Therefore, the objective of the present study was to develop a technique for imaging survival of transplanted islets in the peritransplant and early posttransplant phase...
  21. ncbi Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation
    Robert B Elliott
    Living Cell Technologies, Aukland, New Zealand
    Xenotransplantation 14:157-61. 2007
    ..The long-term viability and function of transplanted encapsulated neonatal porcine islets was examined in a diabetic patient...
  22. ncbi Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling
    C Toso
    Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 8:701-6. 2008
    ..Altogether, this study demonstrates the feasibility and safety of MRI-based islet graft monitoring in clinical practice. Iron overload (spontaneous or induced) represents the major obstacle to the technique...
  23. ncbi Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia
    Montserrat Biarnés
    Laboratory of Diabetes and Experimental Endocrinology, Endocrine Unit, CSUB Hospital de Bellvitge, University of Barcelona, Barcelona, Spain
    Diabetes 51:66-72. 2002
    ..Increased apoptosis and reduced beta-cell mass were also found in islets exposed to chronic hyperglycemia, suggesting that sustained hyperglycemia increased apoptosis in transplanted beta-cells...
  24. ncbi Successful islet transplantation: continued insulin reserve provides long-term glycemic control
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, 2000 College Plaza, 8215 112th Street, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 51:2148-57. 2002
    ..Islet transplantation is a reasonable option in those with severe problems with glycemic lability or hypoglycemia...
  25. ncbi Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation
    Ki Soo Park
    Department of Molecular Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Transplantation 89:509-17. 2010
    ..We hypothesized that MSC-secreted molecules would induce a trophic effect in pancreatic islet culture conditions...
  26. ncbi Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation
    Lorenzo Piemonti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Via Olgettina, Milan, Italy University of Milano Bicocca, Milan, Italy
    Diabetes 51:55-65. 2002
    ....
  27. ncbi Optimal implantation site for pancreatic islet transplantation
    S Merani
    Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Br J Surg 95:1449-61. 2008
    ..About half of the islets introduced into the liver die during or shortly after transplantation. Although many patients achieve insulin independence after portal vein infusion of islets, in the long term most resume insulin injections...
  28. pmc Donor islet endothelial cells in pancreatic islet revascularization
    Daniel Nyqvist
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Diabetes 60:2571-7. 2011
    ..We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization rate, vascular density, and endocrine graft function after transplantation of freshly isolated and cultured islets...
  29. ncbi Positron emission tomography in clinical islet transplantation
    O Eriksson
    Department of Radiology, Oncology and Clinical Immunology, Division of Radiology, University Hospital, Uppsala, Sweden
    Am J Transplant 9:2816-24. 2009
    ..The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation...
  30. ncbi In vivo imaging of islet transplantation
    Natalia V Evgenov
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Room 2301, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Med 12:144-8. 2006
    ..We anticipate that the information obtained in this study would ultimately result in the ability to detect and monitor islet engraftment in humans, which would greatly aid the clinical management of this disease...
  31. ncbi Proliferation of sorted human and rat beta cells
    G Parnaud
    Department of Genetic Medicine and Development, University Medical Center, 1 rue Michel Servet, 1211, Geneva 4, Switzerland
    Diabetologia 51:91-100. 2008
    ..The aim of the study was to determine whether purified beta cells can replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth factors...
  32. ncbi Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    N Lumelsky
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-4092, USA
    Science 292:1389-94. 2001
    ..When injected into diabetic mice, the insulin-producing cells undergo rapid vascularization and maintain a clustered, islet-like organization...
  33. ncbi Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation and Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 293:830-5. 2005
    ..However, for islet transplants to become a widespread clinical reality, diabetes reversal must be achieved with a single donor to reduce risks and costs and increase the availability of transplantation...
  34. pmc Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice
    Jide Tian
    Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e25337. 2011
    ....
  35. pmc Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses
    Michele Carvello
    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:155-65. 2012
    ..Anti-CD22/cal-mediated B-cell depletion promotes the reduction of the anti-islet immune response in various models of islet transplantation...
  36. pmc Update on islet transplantation
    Michael McCall
    Clinical Islet Transplant Program and Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    Cold Spring Harb Perspect Med 2:a007823. 2012
    ....
  37. pmc Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9
    Yunchuan Ding
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Diabetes 58:1797-806. 2009
    ..Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified...
  38. ncbi Recurrent autoimmunity accelerates destruction of minor and major histoincompatible islet grafts in nonobese diabetic (NOD) mice
    T Okitsu
    Division of Transplantation, University of Maryland School of Medicine, Baltimore, USA
    Am J Transplant 1:138-45. 2001
    ..032). In conclusion, autoimmune processes facilitate the alloimmune response to minor and major histocompatibility antigens and accelerate graft destruction. The same autoimmune processes are more pronounced in the intraportal site...
  39. pmc Trimodal gadolinium-gold microcapsules containing pancreatic islet cells restore normoglycemia in diabetic mice and can be tracked by using US, CT, and positive-contrast MR imaging
    Dian R Arifin
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA
    Radiology 260:790-8. 2011
    ..To develop microcapsules that immunoprotect pancreatic islet cells for treatment of type I diabetes and enable multimodal cellular imaging of transplanted islet cells...
  40. ncbi Alternative transplantation sites for pancreatic islet grafts
    Elisa Cantarelli
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Curr Diab Rep 11:364-74. 2011
    ..This review discusses site-specific benefits and drawbacks taking into account immunologic, metabolic, and technical aspects to identify the ideal microenvironment for islet function and survival...
  41. pmc Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice
    Shounan Yi
    Centre for Transplant and Renal Research, Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    Diabetes 61:1180-91. 2012
    ....
  42. pmc A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells
    Richard Olsson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 60:2068-75. 2011
    ..Although islet oxygenation has been extensively studied in vitro, little is known about it in vivo. The current study aimed to investigate the oxygenation of the endocrine pancreas in vivo...
  43. ncbi A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
    Hirofumi Noguchi
    Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Nat Med 10:305-9. 2004
    ..In addition, it did not affect insulin secretion, whereas FK506 caused a dose-dependent decrease in insulin secretion. Cell-permeable peptides can thus provide a new strategy for drug development and may eventually be useful clinically...
  44. ncbi Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 50:301-7. 2001
    ..Altogether, these data and previous results from our laboratory suggest that human beta-cell neogenesis becomes more dependent on differentiation and less dependent on proliferation with increasing age...
  45. ncbi Kidney function after islet transplant alone in type 1 diabetes: impact of immunosuppressive therapy on progression of diabetic nephropathy
    Paola Maffi
    Department of Medicine, Transplant Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Diabetes Care 30:1150-5. 2007
    ..The aim of our study was to assess the impact of the Edmonton immunosuppressive protocol (tacrolimus-sirolimus association) on kidney function...
  46. ncbi Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
    D Jacobs-Tulleneers-Thevissen
    Diabetes Research Center, Brussels Free University, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 56:1605-14. 2013
    ..This study examined in immunodeficient mice whether alginate-encapsulated graft function was inferior to that of free grafts of the same size and composition...
  47. ncbi Bone marrow as an alternative site for islet transplantation
    Elisa Cantarelli
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Blood 114:4566-74. 2009
    ..The results of our study open a research line with potentially significant clinical impact, not only for the treatment of diabetes, but also for other diseases amenable to treatment with cellular transplantation...
  48. ncbi Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  49. ncbi Comparison of the portal vein and kidney subcapsule as sites for primate islet autotransplantation
    Amer Rajab
    Department of Surgery, Division of Transplantation, The Ohio State University, Columbus, OH 43210, USA
    Cell Transplant 17:1015-23. 2008
    ..The other four animals remained hyperglycemic. We conclude that the portal vein is superior to the kidney subcapsule as a site for islet transplantation in nonhuman primates 10 days posttransplantation...
  50. pmc Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 57:2341-7. 2008
    ..Preclinical murine models have shown that rapamycin enhances nTreg proliferation and regulatory function also in vivo. Objective of this study was to assess whether rapamycin has in vivo effects on human nTregs...
  51. ncbi Porcine CTLA4-Ig prolong islet xenografts in rats by downregulating the direct pathway of T-cell activation
    Chao Zhai
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an, China
    Xenotransplantation 18:40-5. 2011
    ..Porcine pancreatic islets fused with pCTLA4-Ig were transplanted into diabetic rats. Xenografts survival was observed, and the underlying immunological rejection mechanisms were investigated...
  52. ncbi The role of the innate immunity in islet transplantation
    Lisa Moberg
    Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Sweden
    Ups J Med Sci 110:17-55. 2005
    ..These findings have provided new insight into the nature of the IBMIR and offer several new strategies to improve the outcome of clinical islet transplantation...
  53. ncbi Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture
    Christian Toso
    Clinical Islet Transplant Program, Department of Surgery, University of Alberta, Edmonton, AB, Canada
    Transpl Int 23:259-65. 2010
    ..Overall, these data demonstrate the beneficial effect of liraglutide on cultured human islets, preserving islet mass. They support the design of clinical studies looking at the effect of liraglutide in clinical islet transplantation...
  54. ncbi Sustained reversal of diabetes following islet transplantation to striated musculature in the rat
    Tormod Lund
    Surgical Clinic, Section for Transplantation, Rikshospitalet University Hospital, Oslo, Norway
    J Surg Res 160:145-54. 2010
    ..In the present study, a technique for intramuscular islet transplantation was developed and compared with intraportal islet transplantation in a syngeneic rat model...
  55. ncbi Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
    Sanja Cabric
    Division of Clinical Immunology, Department of Oncology, Radiology, and Clinical Immunology, The Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Diabetes 56:2008-15. 2007
    ..To avoid systemic treatment, the aim of the present study was to render the islet graft blood biocompatible by applying a continuous heparin coating to the islet surface...
  56. ncbi Low revascularization of human islets when experimentally transplanted into the liver
    Joey Lau
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Transplantation 87:322-5. 2009
    ..Human islets transplanted intraportally into the liver become poorly revascularized. This could contribute to the loss of function in human islets transplanted into the liver over time...
  57. ncbi Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation
    Lisa Ozmen
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, University Hospital, Uppsala, Sweden
    Diabetes 51:1779-84. 2002
    ..This protective effect indicates that thrombin plays a pivotal role in IBMIR and suggests that thrombin inhibition can improve the outcome of clinical islet transplantation...
  58. pmc Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation
    Ida Rasmusson Duprez
    Uppsala University, Department of Oncology, Radiology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, Uppsala, Sweden
    Ups J Med Sci 116:8-17. 2011
    ..In this study, we investigated the capacity of human mesenchymal stem cells (MSCs) to adhere to human islets of Langerhans and their effects in immune modulation and during blood interactions in vitro...
  59. pmc In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver
    M Shimoda
    Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Baylor Heart and Vascular Institute, 621 North Hall St, Suite H030, Dallas, TX 75226, USA
    Diabetologia 53:1669-79. 2010
    ..Here we examined the effect of non-viral VEGF delivery using UTMD on transplanted islets in vivo...
  60. pmc Revascularization of transplanted islets: can it be improved?
    Marcela Brissova
    Department of Medicine, Division of Diabetes, Endocrinology, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 57:2269-71. 2008
  61. ncbi Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning
    D Yin
    Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, Illinois, USA
    Am J Transplant 6:60-8. 2006
    ..These data suggest that islet embolism in the portal vein is a major cause of functional loss following IPIT that can be prevented by liver IP...
  62. ncbi Revascularization and microcirculation of freely grafted islets of Langerhans
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, D-66421 Homburg/Saar, Germany
    World J Surg 25:509-15. 2001
    ..The improvement of islet graft vascularization and the maintenance of adequate microvascular perfusion will contribute to the increased success of pancreatic islet transplantation...
  63. pmc Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye
    Stephan Speier
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE 17176 Stockholm, Sweden
    Nat Protoc 3:1278-86. 2008
    ..Transplantation to the anterior chamber of the eye takes 25 min, and in vivo imaging 1-5 h, depending on the features monitored...
  64. ncbi Alginate-based microcapsules for immunoisolation of pancreatic islets
    Paul De Vos
    Department of Pathology and Laboratory Medicine, Division of Medical Biology, University Hospital of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Biomaterials 27:5603-17. 2006
    ..New approaches in which newly discovered inflammatory responses are silenced bring the technology of transplantation of immunoisolated cells close to clinical application...
  65. pmc Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates
    Dora M Berman
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Diabetes 59:2558-68. 2010
    ..To test the graft-promoting effects of mesenchymal stem cells (MSCs) in a cynomolgus monkey model of islet/bone marrow transplantation...
  66. ncbi Clinical islet transplantation: advances and immunological challenges
    Camillo Ricordi
    University of Miami School of Medicine, Diabetes Research Institute, Miami, Florida 33136, USA
    Nat Rev Immunol 4:259-68. 2004
  67. ncbi Autoantibody response to islet transplantation in type 1 diabetes
    E Bosi
    Medicine and Surgery, San Raffaele Hospital Scientific Institute, Milan, Italy
    Diabetes 50:2464-71. 2001
    ..These data are consistent with a reactivation of autoimmunity that may be dependent on immunosuppression therapy and is associated with impaired graft function...
  68. ncbi Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice
    Y Clare Zhang
    Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0275, USA
    Diabetes 52:708-16. 2003
    ..These studies support the utility of immunoregulatory cytokine gene therapy delivered by rAAV for preventing autoimmune disease recurrence in transplant-based therapies for type 1 diabetes...
  69. ncbi Measurements of oxygen tension in native and transplanted rat pancreatic islets
    P O Carlsson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 47:1027-32. 1998
    ..e., when revascularization has occurred. Furthermore, persistent hyperglycemia in the recipient leads to a further decrease in graft oxygen tension. To what extent this may contribute to islet graft failure is at present unknown...
  70. ncbi Magnetic resonance imaging of transplanted mouse islets labeled with chitosan-coated superparamagnetic iron oxide nanoparticles
    J H Juang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Transplant Proc 42:2104-8. 2010
    ..Our results indicate that isolated mouse islets labeled with CSPIO nanoparticles can be effectively and safely imaged by using MRI as long as 18 weeks after transplantation...
  71. ncbi Five stages of evolving beta-cell dysfunction during progression to diabetes
    Gordon C Weir
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 53:S16-21. 2004
    ..For type 1 diabetes, as remission develops, progression from stage 4 to stage 2 is typically found. Delineation of these stages provides insight into the pathophysiology of both progression and remission of diabetes...
  72. ncbi Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    E A Ryan
    Department of Medicine, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Diabetes 50:710-9. 2001
    ..An elevation of creatinine appears to be a contraindication to this immunosuppressive regimen. For the subjects who had labile type 1 diabetes that was difficult to control, the risk-to-benefit ratio is in favor of islet transplantation...
  73. ncbi IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
    Clara Westwell-Roper
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Immunol 187:2755-65. 2011
    ..These data raise the possibility that islet amyloid-induced inflammation contributes to β cell dysfunction in type 2 diabetes and islet transplantation...
  74. pmc Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation
    Richard Olsson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 60:2350-3. 2011
    ..No previous study has measured the oxygenation of intraportally transplanted islets, although recent data suggest that insufficient engraftment may result in hypoxia and loss of islet cells...
  75. ncbi B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
    Chengyang Liu
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 13:1295-8. 2007
    ..Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy...
  76. pmc Reversal of established autoimmune diabetes by restoration of endogenous beta cell function
    S Ryu
    Immunobiology Laboratory, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Clin Invest 108:63-72. 2001
    ..A therapy aimed at the selective elimination of autoreactive cells and the reeducation of T cells, when combined with control of glycemia, is thus able to effect an apparent cure of established type 1 diabetes in the NOD mouse...
  77. pmc Influence of microenvironment on engraftment of transplanted β-cells
    Per Ola Carlsson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 116:1-7. 2011
    ....
  78. ncbi Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation
    Helena Johansson
    The Rudbeck Laboratory, University Hospital, 751 85 Uppsala, Sweden
    Diabetes 54:1755-62. 2005
    ..In conclusion, tissue factor present in both the islets and the culture medium and elicits IBMIR, which affects the function of the transplanted islets...
  79. pmc Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets
    Gustaf Christoffersson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 59:2569-78. 2010
    ..The aim of the current study was to evaluate striated muscle as a potential angiogenic site for islet transplantation...
  80. ncbi Magnetic resonance imaging of pancreatic islets transplanted into the liver in humans
    Frantisek Saudek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Transplantation 90:1602-6. 2010
    ..We report the first results of a pilot trial aiming to test the feasibility and safety of this technique in humans...
  81. pmc Noninvasive imaging of islet grafts using positron-emission tomography
    Yuxin Lu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1735, USA
    Proc Natl Acad Sci U S A 103:11294-9. 2006
    ..These studies lay a foundation for noninvasive quantitative assessments of islet graft survival using PET...
  82. pmc Islet transplantation a decade later and strategies for filling a half-full glass
    R Paul Robertson
    Division of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington, USA
    Diabetes 59:1285-91. 2010
    ..In the end, I hope to strike a positive note about where this procedure is going, and how it will be applied to establish insulin independence in patients with type 1 diabetes...
  83. ncbi Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes
    M D Bellin
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 8:2463-70. 2008
    ..Our results suggest this immunosuppressive protocol may allow long-term graft survival...
  84. pmc Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice
    Juliet A Emamaullee
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 58:1302-11. 2009
    ..The effect of neutralizing anti-IL-17 and recombinant IL-25 on the development of diabetes in NOD mice, a model of spontaneous autoimmune diabetes, was investigated in this study...
  85. doi Widespread amyloid deposition in transplanted human pancreatic islets
    Gunilla T Westermark
    N Engl J Med 359:977-9. 2008
  86. ncbi Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets
    B Vasir
    Joslin Diabetes Center and Dept. of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 71:924-35. 2001
    ....
  87. ncbi Role of CCL2/MCP-1 in islet transplantation
    Raffaella Melzi
    Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy
    Cell Transplant 19:1031-46. 2010
    ..Strategies to selectively decrease recipient, but not donor, CCL2 release may increase the success of islet transplantation...
  88. ncbi Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells
    Vikash Chandra
    National Centre for Cell Science, Ganeshkhind, Pune, India
    Stem Cells 27:1941-53. 2009
    ..p. into streptozotocin-induced diabetic mice, restored normoglycemia within 2 weeks. The data presented here demonstrate the feasibility of using ASCs as a source of autologous stem cells to differentiate into the pancreatic lineage...
  89. ncbi Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity
    D Jacobs-Tulleneers-Thevissen
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 53:1690-9. 2010
    ..The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepatic site such as omentum...
  90. ncbi Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    Takeru Matsuda
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 5:484-93. 2005
    ..These results suggest that inhibition of the p38 pathway may become a new therapeutic strategy to improve graft survival in clinical islet transplantation...
  91. pmc Fluorocapsules for improved function, immunoprotection, and visualization of cellular therapeutics with MR, US, and CT imaging
    Brad P Barnett
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA
    Radiology 258:182-91. 2011
    ..To develop novel immunoprotective alginate microcapsule formulations containing perfluorocarbons (PFCs) that may increase cell function, provide immunoprotection for xenografted cells, and simultaneously enable multimodality imaging...
  92. ncbi Sirolimus is associated with reduced islet engraftment and impaired beta-cell function
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Diabetes 55:2429-36. 2006
    ..These data suggest that sirolimus, administered in the early posttransplantation phase, is a confounding factor for reduced islet engraftment and impaired beta-cell function in transplants...
  93. ncbi Prevalence of hepatic steatosis after islet transplantation and its relation to graft function
    Ravi Bhargava
    Department of Radiology and Diagnostic Imaging, 2A2 42 Walter C Mackenzie Health Sciences Centre, University of Alberta, 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada
    Diabetes 53:1311-7. 2004
    ..001). MRI-detected steatosis is a common finding; the steatosis appears to be due to a paracrine action of insulin secreted from intrahepatic islets. Hepatic steatosis may be associated with insulin resistance or graft dysfunction...
  94. ncbi Islet transplantation for brittle type 1 diabetes: the UIC protocol
    A Gangemi
    Division of Transplantation Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA
    Am J Transplant 8:1250-61. 2008
    ..1 to 5.8 +/- 0.3 after 1 Tx in Group 2). HYPO scores markedly decreased in both groups. Combined treatment of etanercept and exenatide improves islet graft function and facilitates achievement of insulin-independence with less islets...
  95. ncbi Composite islet-endothelial cell grafts: a novel approach to counteract innate immunity in islet transplantation
    Ulrika Johansson
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, Uppsala University, Sweden
    Am J Transplant 5:2632-9. 2005
    ....
  96. ncbi Expression of Fas but not Fas ligand on fetal pig beta cells
    Lijun Bai
    Diabetes Transplant Unit, Prince of Wales Hospital, The University of New South Wales, Sydney, NSW, Australia
    Xenotransplantation 11:426-35. 2004
    ....
  97. ncbi Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function
    Valeria Sordi
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, 20132 Milan, Italy
    Stem Cells 28:140-51. 2010
    ..These results suggest that pMSCs could exert an indirect role of "helper" cells in tissue repair processes...
  98. pmc MRI assessment of ischemic liver after intraportal islet transplantation
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
    Transplantation 87:825-30. 2009
    ..The resultant ischemia causes necrosis or apoptosis of cells within the liver. Thus, noninvasive assessment of the liver receiving the islet transplant is important to evaluate the status islet grafts...
  99. pmc A novel method for quantitative monitoring of transplanted islets of langerhans by positive contrast magnetic resonance imaging
    L A Crowe
    Department of Radiology Cell Isolation and Transplant Center, Department of Surgery, University of Geneva School of Medicine and Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 11:1158-68. 2011
    ..This imaging protocol reliably quantifies transplanted islet mass and has high translational potential to clinical studies of transplanted pancreatic islets...
  100. ncbi Imaging islets labeled with magnetic nanoparticles at 1.5 Tesla
    Joo Ho Tai
    FRCPath, Novartis Stiller Professor of Xenotransplantation, Robarts Research Institute, Room 200, SDRI Building, University of Western Ontario, 1400 Western Rd, London, Ontario, Canada
    Diabetes 55:2931-8. 2006
    ..These data provide evidence that islets can be labeled with SPIO and imaged using clinically available 1.5- T MRI...
  101. ncbi Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody
    R Damaris Molano
    Cell Transplant Center, Diabetes Research Institute, Miami, FL 33136, USA
    Transplantation 75:1812-9. 2003
    ....

Research Grants80

  1. Spleen regulation of beta-cell regeneration
    Anita Chong; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..The PANIC ATTAC mouse allows the unique opportunity to evaluate beta cell regeneration following the cell specific and titratable induction of apoptosis. ..
  3. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..This will decrease the number of islets required to achieve normoglycemia in type I diabetic patients. ..
  4. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ....
  5. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-DK-101: "Discovery of biomarkers for disease risk, progression or response to therapy in diseases of interest to NINDK" ..
  6. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2012
    ....
  7. Neural control of adaptive Beta-cell growth in insulin resistant rats
    WILLIAM CHARLES DIAZ; Fiscal Year: 2011
    ..Ultimately, further understanding of neurally influenced growth of b-cells may even lead to improvements in islet transplantation and, conceivably, through enhanced functional mass through pharmacological means. ..
  8. Novel Strategies to Increase Insulin Independence after Islet Autotransplantation
    Hongjun Wang; Fiscal Year: 2013
    ..abstract_text> ..
  9. Role of macrophages in pancreatic islet graft rejection
    Midhat H Abdulreda; Fiscal Year: 2013
    ..These findings will have implications in transplantation therapies in general, as well as in cancer and autoimmune conditions. ..
  10. Delayed Tolerance Induction in Living Related Donor Renal Transplant Recipients
    Suzanne T Ildstad; Fiscal Year: 2012
    ....
  11. Epigenomics of the regenerating and aging beta-cell
    Klaus H Kaestner; Fiscal Year: 2013
    ..If successful, this novel approach holds great promise for the development of innovative treatments for diabetes. ..
  12. Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of Diabetes
    Hongjun Wang; Fiscal Year: 2013
    ..Based on our active islet transplantation program at MUSC, this treatment procedure can be readily translated into therapy to benefit patient care. ..
  13. ATF3 and iNOS in Islet Distruction and Graft Rejection
    Tsonwin Hai; Fiscal Year: 2010
    ..abstract_text> ..
  14. ENVIRONMENTAL BETA CELL TOXINS - MECHANISMS OF ACTION
    Glenn Wilson; Fiscal Year: 2012
    ..The studies in this aim will explore whether the fusion proteins developed in the first aim can be used to help overcome this problem. ..
  15. Parathyroid Hormone-Related Protein and the Pancreatic Beta Cell
    Rupangi C Vasavada; Fiscal Year: 2012
    ....
  16. 2011 Rachmiel Levine Diabetes and Obesity Symposium: Advances in Diabetes Biology
    Fouad R Kandeel; Fiscal Year: 2011
    ....
  17. Hepatocyte Growth Factor and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2013
    ....
  18. T Cell Memory in Organ Transplantation
    Fadi G Lakkis; Fiscal Year: 2010
    ..Congenic markers will be used to track adoptively transferred CD8 memory T cells. Gene knockout mice and monoclonal antibodies will be used to examine the roles of chemokine receptors and adhesion molecules. ..
  19. Role of the Hippo Pathway in Pancreas Development
    Nicholas George; Fiscal Year: 2012
    ..abstract_text> ..
  20. Fas pathway in organ-specific tolerance and autoimmunity
    ABDEL HAMAD; Fiscal Year: 2010
    ..Identifying the mechanisms by which blockade of the Fas pathway prevents autoimmune diabetes in animal models could prove useful in developing new therapeutic strategies for T1D. ..
  21. Pancreas perfusion with PFC-Unisol
    MICHAEL JOHN TAYLOR; Fiscal Year: 2011
    ..This research is focused on the development of a new alternative technique to sustain oxygen delivery to the organ using perfusion technology with new inert oxygen-carrying solutions. ..
  22. Non-Enzymatic Cryogenic Isolation of Therapeutic Cells
    MICHAEL JOHN TAYLOR; Fiscal Year: 2012
    ....
  23. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    RODERICK PAUL ROBERTSON; Fiscal Year: 2013
    ..We envision the results will provide novel insights that will pertain not only to improving outcomes in TP/AIT recipients but also insights that will improve outcomes in alloislet transplantation for type 1 diabetic patients. ..
  24. Pancreas Imaging by Pretargeting the Islet Beta Cells
    Guozheng Liu; Fiscal Year: 2010
    ....
  25. Array development of anti-inflammatory peptoid-graft polymers for islet delivery
    Matthew Webber; Fiscal Year: 2013
    ....
  26. Adipose Stromal Cells and Vasculogenesis: Tissue Perfusion and Islet Survival
    KEITH LEONARD MARCH; Fiscal Year: 2013
    ..Successful work to treat diabetes and diabetic vascular disease will markedly improve the effectiveness, and may indeed decrease longterm costs of healthcare in the Veterans Administration system. ..
  27. Novel Costimulation Blockers in Islet Transplantation
    Scott M Krummey; Fiscal Year: 2013
    ....
  28. Endocrine pancreatic cell regeneration from bone marrow
    Mehboob A Hussain; Fiscal Year: 2010
    ..4) To identify the cell type within BM that contributes to the pancreatic endocrine cell population. The long-term goal of these studies is to evaluate transplantation of BM derived cells as a potential treatment for diabetes mellitus. ..
  29. Development of Human beta cell-specific AAV Vectors for Type I Diabetes
    Roland M Tisch; Fiscal Year: 2013
    ..In this way, initial steps wil be taken towards our long-term goal of using AAV vectors to establish [unreadable] cell-specific and/or islet graft tolerance for human T1D. ..
  30. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..Success of this study is expected to have significant impact in the field of islet transplantation treatment for type 1 diabetes. ..
  31. Treg suppression of islet allograft rejection
    Ramakrishna Vankayalapati; Fiscal Year: 2013
    ....
  32. Clinical Refinement of islet transplantation
    NICOLE ANN TURGEON; Fiscal Year: 2011
    ....
  33. ApoFasL as a novel treatment for Type 1 Diabetes in Nonhuman Primates
    Haval Shirwan; Fiscal Year: 2011
    ..This novel therapy has the potential to break new grounds for the clinical treatment of T1D. ..
  34. PHOSPHOLIPID-DERIVED MEDIATORS AND INSULIN SECRETION
    John W Turk; Fiscal Year: 2010
    ..We have prepared mouse embryonic stem cells in which an iPLA2p allele has been disrupted by homologous recombination as a step to generate mice that do not express the enzyme. ..
  35. Dynamic Dendronized Polymers for Effective siRNA Delivery to Pancreatic Islets
    Zhibin Guan; Fiscal Year: 2013
    ..Successful demonstration of this project will introduce a new generation of synthetic vectors for siRNA delivery and improve the outcome of islets transplantation and help developing treatment for type 1 diabetes. ..
  36. Combined siRNA Therapy and In-vivo Imaging in Islet Transplantation
    Anna Moore; Fiscal Year: 2011
    ....
  37. NOVEL THERMAL REVERSIBLE POLYMER (TRG) FOR HUMAN ISLET ENCAPSULATION AND IMPLANTA
    David W Scharp; Fiscal Year: 2011
    ..The next phase of this study will be to advance these studies onto large diabetic animals to determine what would be required to take this novel new encapsulating gel into a clinical product for patients with diabetes. ..
  38. Two Phase Approach to Pancreatic Islet Transplantation
    BHUPINDER SINGH SHERGILL; Fiscal Year: 2013
    ..The mentoring team will guide the trainee in this high impact and multidisciplinary approach toward the reversal of type 1 diabetes. ..
  39. Mechanisms Regulating Functional Beta-cell Recovery
    Gordon P Meares; Fiscal Year: 2010
    ..If AMPK controls a survival pathway this would potentially be a new target for therapeutic intervention to attenuate [unreadable]-cell loss in prediabetic persons and in islet transplantation. ..
  40. Human islet transplantation on microporous scaffolds
    Lonnie D Shea; Fiscal Year: 2010
    ..In this proposal, we investigate the ability of the scaffolds to enhance engraftment and function of human islets. ..
  41. A perfluorocarbon-based culture device for beta cell biology applications (Phase
    Camillo Ricordi; Fiscal Year: 2013
    ..Success in these studies will also provide proof of principle of the superiority of our oxygen enhancing technology for many other cell culture applications. ..
  42. Sitagliptin therapy to improve outcomes after islet autotransplantation.
    Melena D Bellin; Fiscal Year: 2013
    ..This project will explore patient characteristics and an intervention which may improve the success of islet transplant. ..
  43. Protein-Releasing Microporous Scaffolds for Cell Replacement Therapy
    Lonnie D Shea; Fiscal Year: 2013
    ..These scaffolds provide a support for cell growth and can deliver proteins which will be to enhance cell survival and function following islet transplantation. ..
  44. Protein Kinase C (PKC) Zeta and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2012
    ..If translated into humans, activation of PKC ? may be an attractive therapeutic strategy for expanding beta cell mass and function in patients with diabetes. ..
  45. Lipid Mediators in Pancreatic Islet Dysfunction
    Jerry L Nadler; Fiscal Year: 2010
    ..The findings should provide new methods to preserve beta-cell mass ultimately leading to new therapeutic modalities to prevent T1DM and improve ability to reverse T1DM using islet transplantation. ..
  46. Approaches to Tolerance of Allogeneic Kidney and Islet Transplants
    David H Sachs; Fiscal Year: 2013
    ..abstract_text> ..
  47. UCHSC Diabetes and Endocrinology Research Center
    John C Hutton; Fiscal Year: 2010
    ..iicnsc.edu/inisc/diabetes/derc) that also serves as the major conduit for the advertising, ordering and billing for Core services that are offered on a discounted fee-for-service basis to DERC members. ..
  48. Contribution of Toll-like receptor signaling in islet transplantation
    Bernd Schroppel; Fiscal Year: 2010
    ..A detailed understanding of their role in islet recovery and transplantation may provide new therapeutic approaches in islet transplantation without toxic effects on islet cells and without compromising the whole immune system. ..
  49. Bioactive Gels that Promote Long-Term Islet Survival and Function
    Kristi S Anseth; Fiscal Year: 2012
    ..If successful, this strategy will prolong the duration and function of transplanted pancreatic tissue without the need for life-long administration of immunosuppressive drugs. ..
  50. Beta Cell Specific Microfluidic Perifusion and Imaging for Islet Potency Testing
    Jose Oberholzer; Fiscal Year: 2013
    ..This microfluidic system could represent a reliable islet potency assay for current and future islet replacement therapies, as well as for the study of new diabetes therapies in general. ..
  51. A Bioengineering Approach to Create Immunorejection Free Human Pancreatic Islets
    Luguang Luo; Fiscal Year: 2013
    ..Our long term goal is to identify the mechanism(s) by which encapsulated islets plus BM cells sustain islet function in vivo and prevent islet rejection in the absence of generalized immunosuppression for translation to the clinic. ..
  52. A Novel Approach of beta Cell Replacement to Reverse Type I Diabetes in NOD Mice
    Roland M Tisch; Fiscal Year: 2013
    ..Experiments will also be included to assess the effects of ectopic prolactin expression on inflammation in the pancreas. ..
  53. Pediatric Endocrine Fellowship Training in Diabetes Research
    CHARLES ALFRED STANLEY; Fiscal Year: 2012
    ..This shortage has been emphasized by the American Diabetes Association, the Juvenile Diabetes Research Foundation, and the Pediatric Academic Societies. ..
  54. Targeting Blys/Baff in non-human primate islet transplantation
    Ali Naji; Fiscal Year: 2013
    ..We will test this clinically pertinent concept in the setting of islet alo-transplantation in Cynomolgus monkeys. ..
  55. STEM CELL-DERIVED INSUIN PRODUCING CELLS CORRECT HYPERGLYCEMIA IN DIABETIC MICE
    Nicholas Zavazava; Fiscal Year: 2013
    ..These experiments are based on both mouse ES cells and on human iPS cells. If we are successful, we will establish a novel source of IPCs that will have a direct impact on the health and treatment of Veterans. ..
  56. Suppression of Allograft Rejection by A Novel Protein ESAT-6
    Buka Samten; Fiscal Year: 2013
    ..Therefore this project has important clinical implications for the cure of type 1 diabetes by islet transplantation and perhaps other end-stage organ diseases via solid organ transplantation. ..
  57. Effects of Lymphangiogenesis Blockade on Skin Allograft Rejection
    GILLES A BENICHOU; Fiscal Year: 2013
    ....
  58. Career Development Program in Pediatric Diabetes Research (K12) at CHOP
    Steven M Willi; Fiscal Year: 2013
    ..and is strongly supported by access to a superb range of institutional resources, including the CHOP CTRC and the UPenn DERC. ..
  59. CXCR3 Chemokines in Type I Diabetes
    Matthias von Herrath; Fiscal Year: 2009
    ..Aim 1: Importance of IP-10 in the pathogenesis of T1D - therapeutic blockade and mechanistic analyses. Aim 2: Importance of IP-10 during islet allograft rejection - therapeutic blockade and mechanistic analyses. ..
  60. DIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sensing
    Michael T McMahon; Fiscal Year: 2013
    ..This proposal is focused on the production of immunoprotective islet cell capsules which are appropriate for treatment and allow MR monitoring of the pH these islets using biodegradable CEST contrast agents. ..
  61. Islet Transplant - Costimulatory Blockage with LEA29Y
    ANDREW M SHAPIRO; Fiscal Year: 2011
    ..The combination of the CIT consortium trials will change the face of future clinical islet transplantation therapy. ..
  62. ECDI Coupled Cells for Tolerance in Allogeniec Islet Cell Transplantation for T1D
    Xunrong Luo; Fiscal Year: 2010
    ..Successful completion of the proposed study will have significant impact on therapeutic options for patients with type 1 diabetes. ..
  63. Interdisciplinary studies in hormone function
    Neil Aronin; Fiscal Year: 2012
    ....
  64. Pig to Non-Human Primate Islet Xenografts
    Bernhard Hering; Fiscal Year: 2009
    ..These studies are unique and will generate new data on pig-to-NHP XPITx immunobiology and the immune mechanisms influencing development of pig XPITx tolerance. ..
  65. Program Project,Restoration of Endocrine Pancreas Funct*
    JOEL HABENER; Fiscal Year: 2004
    ..This PPA proposes the initial studies on the way to providing a cure for diabetes via the approaches for regenerative medicine. ..
  66. Islet Protection from Hypoxia Posttransplant
    Klearchos K Papas; Fiscal Year: 2010
    ..In addition to improving the quality of life and productivity of these patients, this product can help reduce the cost of health care. ..
  67. Donor CD8+ cell facilitates mixed chimerism in NOD mice
    Defu Zeng; Fiscal Year: 2005
    ..abstract_text> ..
  68. ApoFasL: a Novel Immunotherapeutic for T1D
    Rolf Huseby; Fiscal Year: 2007
    ..The ApoFasL approach, when successful, will ensure a pathway to the treatment of Type 1 diabetes. [unreadable] [unreadable] [unreadable]..
  69. A Novel Method to Isolate Islet Cells
    JERRY KNOBELOCH; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  70. Improved recombinant collagenase for tissue dissociation
    Robert McCarthy; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  71. IMPACT OF STANDARDIZATION AND PROCEDURE OPTIMIZATION ON*
    Ahmed Gaber; Fiscal Year: 2005
    ..This team has worked well together with the aim of curing diabetes through islet transplantation. ..
  72. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..In addition, the development of rapid, accurate, and predictive tests of islet viability and function post isolation will contribute to significant improvements in post transplant success. ..
  73. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2006
    ..We anticipate that the use of pre-vascularized islets as part of a composite islet-kidney transplant may provide a new and effective treatment modality for patients with class I diabetes and end-stage renal disease. ..
  74. B Cell immunomodulation in islet transplantation
    Ali Naji; Fiscal Year: 2006
    ..Our overall contention is that interruption of T- and B- lymphocyte function during the induction phase represents a novel and potentially powerful means of promoting immunological tolerance to islet allografts. ..
  75. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..The research proposed in this grant will provide significant information to the xenotransplant research and the potential use of porcine islets as an alternative to human tissue for pancreatic islet transplantation. ..
  76. Anti-inflammatory Serpin(AAT and Elafin) Gene Transfers*
    Sihong Song; Fiscal Year: 2003
    ..abstract_text> ..
  77. Gene transfer with A20 to improve islet transplantation
    Christiane Ferran; Fiscal Year: 2003
    ..This will overcome the requirement for high numbers of islets and the need for intensive immunosuppression. Beneficial results would pave the way for pre-clinical (primates) and clinical applications. ..
  78. Commercial Feasibility Assessment of Pancreatic Islet Progenitor Cell Technology
    Kelvin Brockbank; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  79. Novel SOD-mimetics for type 1 diabetes
    ELWOOD REYNOLDS; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  80. Tissue Dissociation Enzymes for Islets & Other Cells
    Robert McCarthy; Fiscal Year: 2005
    ..This knowledge offers the potential to use fewer, more effective enzymes in TDE mixtures, leading to increases in the yield and quality of cells recovered from any mammalian organ. ..