islets of langerhans transplantation

Summary

Summary: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.

Top Publications

  1. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
  2. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
  3. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
  4. ncbi Five-year follow-up after clinical islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, 2000 College Plaza, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 54:2060-9. 2005
  5. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
  6. ncbi Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
    Shaoping Deng
    Department of Surgery, Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes 53:624-32. 2004
  7. ncbi Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology, and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:1438-45. 2010
  8. ncbi Revascularization and microcirculation of freely grafted islets of Langerhans
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, D-66421 Homburg/Saar, Germany
    World J Surg 25:509-15. 2001
  9. ncbi Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    E A Ryan
    Department of Medicine, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Diabetes 50:710-9. 2001
  10. ncbi Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model
    Torsten Eich
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, University Hospital, Uppsala, Sweden
    Transplantation 84:893-8. 2007

Detail Information

Publications324 found, 100 shown here

  1. ncbi International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
    ..We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol)...
  2. ncbi Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    A M Shapiro
    Surgical Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada
    N Engl J Med 343:230-8. 2000
    ..Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year...
  3. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  4. ncbi Five-year follow-up after clinical islet transplantation
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, 2000 College Plaza, 8215 112th St, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 54:2060-9. 2005
    ..The results, though promising, still point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression...
  5. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  6. ncbi Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
    Shaoping Deng
    Department of Surgery, Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes 53:624-32. 2004
    ..These results provide direct evidence for abnormalities in the islets of type 2 diabetic patients that may contribute to the pathogenesis of the disease...
  7. ncbi Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology, and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:1438-45. 2010
    ..Background: Bone marrow-derived mesenchymal stem cells (MSCs) are known to produce vascular endothelial growth factor. We hypothesize that co-transplantation of MSCs and islets promotes revascularization and improves islet graft function...
  8. ncbi Revascularization and microcirculation of freely grafted islets of Langerhans
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, D-66421 Homburg/Saar, Germany
    World J Surg 25:509-15. 2001
    ..The improvement of islet graft vascularization and the maintenance of adequate microvascular perfusion will contribute to the increased success of pancreatic islet transplantation...
  9. ncbi Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    E A Ryan
    Department of Medicine, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Diabetes 50:710-9. 2001
    ..An elevation of creatinine appears to be a contraindication to this immunosuppressive regimen. For the subjects who had labile type 1 diabetes that was difficult to control, the risk-to-benefit ratio is in favor of islet transplantation...
  10. ncbi Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model
    Torsten Eich
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, University Hospital, Uppsala, Sweden
    Transplantation 84:893-8. 2007
    ..Therefore, the objective of the present study was to develop a technique for imaging survival of transplanted islets in the peritransplant and early posttransplant phase...
  11. ncbi Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts
    Neal R Barshes
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin, Suite 1628, Houston, TX 77030, USA
    J Leukoc Biol 77:587-97. 2005
    ....
  12. pmc Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates
    Dora M Berman
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Diabetes 59:2558-68. 2010
    ..To test the graft-promoting effects of mesenchymal stem cells (MSCs) in a cynomolgus monkey model of islet/bone marrow transplantation...
  13. ncbi Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    N Lumelsky
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-4092, USA
    Science 292:1389-94. 2001
    ..When injected into diabetic mice, the insulin-producing cells undergo rapid vascularization and maintain a clustered, islet-like organization...
  14. ncbi In vivo imaging of islet transplantation
    Natalia V Evgenov
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Room 2301, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Med 12:144-8. 2006
    ..We anticipate that the information obtained in this study would ultimately result in the ability to detect and monitor islet engraftment in humans, which would greatly aid the clinical management of this disease...
  15. ncbi Proliferation of sorted human and rat beta cells
    G Parnaud
    Department of Genetic Medicine and Development, University Medical Center, 1 rue Michel Servet, 1211, Geneva 4, Switzerland
    Diabetologia 51:91-100. 2008
    ..The aim of the study was to determine whether purified beta cells can replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth factors...
  16. ncbi Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation and Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 293:830-5. 2005
    ..However, for islet transplants to become a widespread clinical reality, diabetes reversal must be achieved with a single donor to reduce risks and costs and increase the availability of transplantation...
  17. ncbi Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  18. pmc Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes
    M D Bellin
    The Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 12:1576-83. 2012
    ..03), regardless of maintenance immunosuppression or other factors. These findings support potential for long-term insulin independence after ITA using potent induction therapy, with anti-CD3 Ab or TCDAb+TNF-α-i...
  19. pmc Donor islet endothelial cells in pancreatic islet revascularization
    Daniel Nyqvist
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Diabetes 60:2571-7. 2011
    ..We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization rate, vascular density, and endocrine graft function after transplantation of freshly isolated and cultured islets...
  20. pmc Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    Paolo Monti
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
    Diabetes 57:2341-7. 2008
    ..Preclinical murine models have shown that rapamycin enhances nTreg proliferation and regulatory function also in vivo. Objective of this study was to assess whether rapamycin has in vivo effects on human nTregs...
  21. ncbi Comparison of the portal vein and kidney subcapsule as sites for primate islet autotransplantation
    Amer Rajab
    Department of Surgery, Division of Transplantation, The Ohio State University, Columbus, OH 43210, USA
    Cell Transplant 17:1015-23. 2008
    ..The other four animals remained hyperglycemic. We conclude that the portal vein is superior to the kidney subcapsule as a site for islet transplantation in nonhuman primates 10 days posttransplantation...
  22. doi Porcine CTLA4-Ig prolong islet xenografts in rats by downregulating the direct pathway of T-cell activation
    Chao Zhai
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an, China
    Xenotransplantation 18:40-5. 2011
    ..Porcine pancreatic islets fused with pCTLA4-Ig were transplanted into diabetic rats. Xenografts survival was observed, and the underlying immunological rejection mechanisms were investigated...
  23. ncbi Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation
    Lisa Ozmen
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, University Hospital, Uppsala, Sweden
    Diabetes 51:1779-84. 2002
    ..This protective effect indicates that thrombin plays a pivotal role in IBMIR and suggests that thrombin inhibition can improve the outcome of clinical islet transplantation...
  24. pmc Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation
    Ida Rasmusson Duprez
    Uppsala University, Department of Oncology, Radiology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, Uppsala, Sweden
    Ups J Med Sci 116:8-17. 2011
    ..In this study, we investigated the capacity of human mesenchymal stem cells (MSCs) to adhere to human islets of Langerhans and their effects in immune modulation and during blood interactions in vitro...
  25. pmc In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver
    M Shimoda
    Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Baylor Heart and Vascular Institute, 621 North Hall St, Suite H030, Dallas, TX 75226, USA
    Diabetologia 53:1669-79. 2010
    ..Here we examined the effect of non-viral VEGF delivery using UTMD on transplanted islets in vivo...
  26. doi Positron emission tomography in clinical islet transplantation
    O Eriksson
    Department of Radiology, Oncology and Clinical Immunology, Division of Radiology, University Hospital, Uppsala, Sweden
    Am J Transplant 9:2816-24. 2009
    ..The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation...
  27. doi Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture
    Christian Toso
    Clinical Islet Transplant Program, Department of Surgery, University of Alberta, Edmonton, AB, Canada
    Transpl Int 23:259-65. 2010
    ..Overall, these data demonstrate the beneficial effect of liraglutide on cultured human islets, preserving islet mass. They support the design of clinical studies looking at the effect of liraglutide in clinical islet transplantation...
  28. doi Sustained reversal of diabetes following islet transplantation to striated musculature in the rat
    Tormod Lund
    Surgical Clinic, Section for Transplantation, Rikshospitalet University Hospital, Oslo, Norway
    J Surg Res 160:145-54. 2010
    ..In the present study, a technique for intramuscular islet transplantation was developed and compared with intraportal islet transplantation in a syngeneic rat model...
  29. ncbi The role of the innate immunity in islet transplantation
    Lisa Moberg
    Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Sweden
    Ups J Med Sci 110:17-55. 2005
    ..These findings have provided new insight into the nature of the IBMIR and offer several new strategies to improve the outcome of clinical islet transplantation...
  30. doi Low revascularization of human islets when experimentally transplanted into the liver
    Joey Lau
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Transplantation 87:322-5. 2009
    ..Human islets transplanted intraportally into the liver become poorly revascularized. This could contribute to the loss of function in human islets transplanted into the liver over time...
  31. ncbi Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
    Sanja Cabric
    Division of Clinical Immunology, Department of Oncology, Radiology, and Clinical Immunology, The Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Diabetes 56:2008-15. 2007
    ..To avoid systemic treatment, the aim of the present study was to render the islet graft blood biocompatible by applying a continuous heparin coating to the islet surface...
  32. pmc Islet transplantation a decade later and strategies for filling a half-full glass
    R Paul Robertson
    Division of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington, USA
    Diabetes 59:1285-91. 2010
    ..In the end, I hope to strike a positive note about where this procedure is going, and how it will be applied to establish insulin independence in patients with type 1 diabetes...
  33. pmc Influence of microenvironment on engraftment of transplanted β-cells
    Per Ola Carlsson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 116:1-7. 2011
    ....
  34. pmc Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9
    Yunchuan Ding
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Diabetes 58:1797-806. 2009
    ..Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified...
  35. ncbi Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation
    Helena Johansson
    The Rudbeck Laboratory, University Hospital, 751 85 Uppsala, Sweden
    Diabetes 54:1755-62. 2005
    ..In conclusion, tissue factor present in both the islets and the culture medium and elicits IBMIR, which affects the function of the transplanted islets...
  36. pmc Noninvasive imaging of islet grafts using positron-emission tomography
    Yuxin Lu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1735, USA
    Proc Natl Acad Sci U S A 103:11294-9. 2006
    ..These studies lay a foundation for noninvasive quantitative assessments of islet graft survival using PET...
  37. ncbi B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
    Chengyang Liu
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 13:1295-8. 2007
    ..Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy...
  38. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010
    ....
  39. ncbi Magnetic resonance imaging of pancreatic islets transplanted into the liver in humans
    Frantisek Saudek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Transplantation 90:1602-6. 2010
    ..We report the first results of a pilot trial aiming to test the feasibility and safety of this technique in humans...
  40. pmc Reversal of established autoimmune diabetes by restoration of endogenous beta cell function
    S Ryu
    Immunobiology Laboratory, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Clin Invest 108:63-72. 2001
    ..A therapy aimed at the selective elimination of autoreactive cells and the reeducation of T cells, when combined with control of glycemia, is thus able to effect an apparent cure of established type 1 diabetes in the NOD mouse...
  41. pmc Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation
    Richard Olsson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 60:2350-3. 2011
    ..No previous study has measured the oxygenation of intraportally transplanted islets, although recent data suggest that insufficient engraftment may result in hypoxia and loss of islet cells...
  42. pmc Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets
    Gustaf Christoffersson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 59:2569-78. 2010
    ..The aim of the current study was to evaluate striated muscle as a potential angiogenic site for islet transplantation...
  43. pmc Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice
    Juliet A Emamaullee
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 58:1302-11. 2009
    ..The effect of neutralizing anti-IL-17 and recombinant IL-25 on the development of diabetes in NOD mice, a model of spontaneous autoimmune diabetes, was investigated in this study...
  44. doi Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes
    M D Bellin
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 8:2463-70. 2008
    ..Our results suggest this immunosuppressive protocol may allow long-term graft survival...
  45. ncbi A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
    Hirofumi Noguchi
    Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Nat Med 10:305-9. 2004
    ..In addition, it did not affect insulin secretion, whereas FK506 caused a dose-dependent decrease in insulin secretion. Cell-permeable peptides can thus provide a new strategy for drug development and may eventually be useful clinically...
  46. ncbi Prevalence of hepatic steatosis after islet transplantation and its relation to graft function
    Ravi Bhargava
    Department of Radiology and Diagnostic Imaging, 2A2 42 Walter C Mackenzie Health Sciences Centre, University of Alberta, 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada
    Diabetes 53:1311-7. 2004
    ..001). MRI-detected steatosis is a common finding; the steatosis appears to be due to a paracrine action of insulin secreted from intrahepatic islets. Hepatic steatosis may be associated with insulin resistance or graft dysfunction...
  47. ncbi Sirolimus is associated with reduced islet engraftment and impaired beta-cell function
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Diabetes 55:2429-36. 2006
    ..These data suggest that sirolimus, administered in the early posttransplantation phase, is a confounding factor for reduced islet engraftment and impaired beta-cell function in transplants...
  48. ncbi Composite islet-endothelial cell grafts: a novel approach to counteract innate immunity in islet transplantation
    Ulrika Johansson
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, Uppsala University, Sweden
    Am J Transplant 5:2632-9. 2005
    ....
  49. doi Islet transplantation for brittle type 1 diabetes: the UIC protocol
    A Gangemi
    Division of Transplantation Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA
    Am J Transplant 8:1250-61. 2008
    ..1 to 5.8 +/- 0.3 after 1 Tx in Group 2). HYPO scores markedly decreased in both groups. Combined treatment of etanercept and exenatide improves islet graft function and facilitates achievement of insulin-independence with less islets...
  50. ncbi Recurrent autoimmunity accelerates destruction of minor and major histoincompatible islet grafts in nonobese diabetic (NOD) mice
    T Okitsu
    Division of Transplantation, University of Maryland School of Medicine, Baltimore, USA
    Am J Transplant 1:138-45. 2001
    ..032). In conclusion, autoimmune processes facilitate the alloimmune response to minor and major histocompatibility antigens and accelerate graft destruction. The same autoimmune processes are more pronounced in the intraportal site...
  51. ncbi Expression of Fas but not Fas ligand on fetal pig beta cells
    Lijun Bai
    Diabetes Transplant Unit, Prince of Wales Hospital, The University of New South Wales, Sydney, NSW, Australia
    Xenotransplantation 11:426-35. 2004
    ....
  52. doi IL-10 gene modified dendritic cells inhibit T helper type 1-mediated alloimmune responses and promote immunological tolerance in diabetes
    Huifen Zhu
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Cell Mol Immunol 5:41-6. 2008
    ..Our studies suggest that IL-10 gene modified DCs can induce the immune tolerance to islet graft and prolong survival of the recipients by the inhibiting of T cell proliferation in allotype mice...
  53. ncbi Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents
    C Gysemans
    LEGENDO, UZ Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Diabetologia 46:1115-23. 2003
    ..The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents in the prevention of PNF after xenogeneic islet transplantation...
  54. ncbi Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody
    R Damaris Molano
    Cell Transplant Center, Diabetes Research Institute, Miami, FL 33136, USA
    Transplantation 75:1812-9. 2003
    ....
  55. doi Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function
    Valeria Sordi
    San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, 20132 Milan, Italy
    Stem Cells 28:140-51. 2010
    ..These results suggest that pMSCs could exert an indirect role of "helper" cells in tissue repair processes...
  56. ncbi Glutathione peroxidase protein expression and activity in human islets isolated for transplantation
    Naoko Tonooka
    Pacific Northwest Research Institute, University of Washington, WA 98122, USA
    Clin Transplant 21:767-72. 2007
    ..Overexpression of antioxidant enzymes has been reported to protect rodent beta cells from oxidative stress. However, very little is known about protein expression and activity of antioxidant enzymes in human islets...
  57. ncbi Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs
    S E Cross
    Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK
    Diabetologia 50:1423-32. 2007
    ..This study investigates the survival-promoting activities of VEGF in human islets and the effects of rapamycin on islet viability...
  58. pmc A novel method for quantitative monitoring of transplanted islets of langerhans by positive contrast magnetic resonance imaging
    L A Crowe
    Department of Radiology Cell Isolation and Transplant Center, Department of Surgery, University of Geneva School of Medicine and Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 11:1158-68. 2011
    ..This imaging protocol reliably quantifies transplanted islet mass and has high translational potential to clinical studies of transplanted pancreatic islets...
  59. ncbi Imaging islets labeled with magnetic nanoparticles at 1.5 Tesla
    Joo Ho Tai
    FRCPath, Novartis Stiller Professor of Xenotransplantation, Robarts Research Institute, Room 200, SDRI Building, University of Western Ontario, 1400 Western Rd, London, Ontario, Canada
    Diabetes 55:2931-8. 2006
    ..These data provide evidence that islets can be labeled with SPIO and imaged using clinically available 1.5- T MRI...
  60. ncbi Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses
    Vincenzo Mirenda
    Department of Immunology, Division of Medicine, Imperial College London, UK
    Diabetes 54:1048-55. 2005
    ..These results suggest that a similar approach could have clinical utility in porcine islet xenotransplantation...
  61. doi Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection
    Yanfei Huang
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 90:1307-11. 2010
    ....
  62. pmc In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates
    Zdravka Medarova
    Department of Radiology, Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 87:1659-66. 2009
    ..The potential translation of these findings to the clinical situation requires validation of our methodology in a non-human primate model, which we have now carried out in baboons (Papio hamadryas) and reported here...
  63. ncbi The pancreatic islet endothelial cell: emerging roles in islet function and disease
    Richard Olsson
    Department of Medical Cell Biology, Biomedical Center, Husargatan 3, Box 571, SE 75123 Uppsala, Sweden
    Int J Biochem Cell Biol 38:492-7. 2006
    ..Insufficient revascularization may severely affect the transport properties of the islet endothelial system, resulting in a dysfunctional islet graft...
  64. ncbi Type 1 diabetes: new perspectives on disease pathogenesis and treatment
    M A Atkinson
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Lancet 358:221-9. 2001
    ..We focus this seminar on these changing views, and offer a new perspective on our understanding of the pathogenesis of type 1 diabetes and on principles for therapeutic management of patients with this disorder...
  65. ncbi Intra-ductal glutamine administration reduces oxidative injury during human pancreatic islet isolation
    J Avila
    University of Illinois at Chicago, Division of Transplantation, Chicago, USA
    Am J Transplant 5:2830-7. 2005
    ..7 nmol/mg of protein vs. 6.54 +/- 1.7 in control; p < 0.05). We conclude that intra-ductal administration of glutamine reduces oxidative injury and apoptosis and improves islet yield and islet graft function after transplantation...
  66. ncbi Pancreatic islet transplantation for treating diabetes
    Shinichi Matsumoto
    Transplantation Unit, Kyoto University Hospital, Diabetes Research Institute Kyoto, Shogoin, Kyoto 606 8507, Japan
    Expert Opin Biol Ther 6:23-37. 2006
    ....
  67. doi Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury
    Yanrong Lu
    Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, China
    Cell Biochem Funct 28:637-43. 2010
    ..This study provides an experimental basis for therapeutic strategies based on enhancing islet function...
  68. pmc Primary graft function, metabolic control, and graft survival after islet transplantation
    Marie Christine Vantyghem
    University Lille Nord de France, Lille, France
    Diabetes Care 32:1473-8. 2009
    ..CONCLUSIONS Optimal PGF was associated with prolonged graft survival and better metabolic control after islet transplantation. This early outcome may represent a valuable end point in future clinical trials...
  69. doi Liposome-mediated transfer can improve the efficacy of islet labeling with superparamagnetic iron oxide
    Y Jiao
    Shanghai Organ Transplantation Clinical Medical Center, the First People s Hospital Affiliated Shanghai Jiao Tong University, Shanghai, China
    Transplant Proc 40:3615-8. 2008
    ..The presence of liposomes increased labeling efficiency at each SPIO concentration. In vitro MRI confirmed the effect of liposomes to improve labeling efficiency of islet cells by SPIO...
  70. ncbi Histological markers for endothelial cells in endogenous and transplanted rodent pancreatic islets
    Goran Mattsson
    Department of Medical Cell Biology, Biomedical Centre, Box 571, Uppsala University, SE 751 23 Uppsala, Sweden
    Pancreatology 2:155-62. 2002
    ..The aim of this study was to identify a selective and specific marker for rodent microvascular endothelial cells, especially for use in studies on the vascular system of pancreatic islets...
  71. pmc Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain
    Esther S O'Sullivan
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocr Rev 32:827-44. 2011
    ..Herein we will review the above issues and chart the progress made with various immunoisolation devices in small and large animal models and the small number of clinical trials carried out to date...
  72. doi CTLA4-Ig-modified dendritic cells inhibit lymphocyte-mediated alloimmune responses and prolong the islet graft survival in mice
    Dao Feng Yang
    Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China
    Transpl Immunol 19:197-201. 2008
    ..Our studies suggest that DCs expressing CTLA4-Ig fusion protein can induce the immune tolerance to islet graft and prolong the allograft survival through the inhibition of T cell proliferation in allogeneic mice...
  73. ncbi Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation
    Lorenzo Piemonti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Via Olgettina, Milan, Italy University of Milano Bicocca, Milan, Italy
    Diabetes 51:55-65. 2002
    ....
  74. pmc Bone marrow cell cotransplantation with islets improves their vascularization and function
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
    Transplantation 89:686-93. 2010
    ..CONCLUSIONS.: Cotransplantation of bone marrow cells with islets is associated with enhanced islet graft vascularization and function...
  75. pmc Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor
    Babak Movahedi
    Diabetes Research Center, Brussels Free University, Brussels, Belgium
    Diabetes 57:2128-36. 2008
    ..The present work examines whether human islet preparations produce VEGF as well as interleukin (IL)-8, another angiogenic protein, and assesses the role of contaminating duct cells in VEGF and IL-8-mediated angiogenesis...
  76. doi Tracking intrahepatically transplanted islets labeled with Feridex-polyethyleneimine complex using a clinical 3.0-T magnetic resonance imaging scanner
    Shanzhong Zhang
    Transplantation Center, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Pancreas 38:293-302. 2009
    ..To evaluate the images acquired with a clinical 3.0-T magnetic resonance imaging machine as the quantification of transplanted and surviving islets in vivo...
  77. ncbi Angiostatic factors normally restrict islet endothelial cell proliferation and migration: implications for islet transplantation
    Asa Johansson
    Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, SE 751 23 Uppsala, Sweden
    Transpl Int 22:1182-8. 2009
    ..Inhibition of angiostatic factors early after transplantation may provide a strategy to restore the islet vascular network and improve islet graft function...
  78. pmc MRI assessment of ischemic liver after intraportal islet transplantation
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
    Transplantation 87:825-30. 2009
    ..The resultant ischemia causes necrosis or apoptosis of cells within the liver. Thus, noninvasive assessment of the liver receiving the islet transplant is important to evaluate the status islet grafts...
  79. ncbi T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts
    Shounan Yi
    National Pancreas Transplant Unit, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    J Immunol 170:2750-8. 2003
    ..This suggests that in xenograft rejection, there are macrophage-specific recognition and targeting signals that are independent of those received by T cells...
  80. doi In vivo visualization of transplanted pancreatic islets by MRI: comparison between in vivo, histological and electron microscopy findings
    Pasquina Marzola
    Department of Morphological and Biomedical Sciences, University of Verona, Strada Le Grazie 8, Verona, Italy
    Contrast Media Mol Imaging 4:135-42. 2009
    ..Differently from reports in the literature, our findings indicate that iron particles could last in the liver for long periods, independently of the presence of intact pancreatic islets...
  81. ncbi Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation
    Lisa Moberg
    Department of Radiology, Oncology, and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, University Hospital, Uppsala, Sweden
    Transplantation 76:1285-8. 2003
    ..In this study, the authors investigated whether compounds previously shown to affect TF and macrophage chemoattractant protein (MCP)-1 expression in monocytes and endothelial cells have the same effect in human islet cells...
  82. ncbi Significant role for Fas in the pathogenesis of autoimmune diabetes
    X Su
    Alexion Pharmaceuticals, New Haven, CT 06511, USA
    J Immunol 164:2523-32. 2000
    ..These results provide evidence that Fas/FasL-mediated programmed cell death plays a significant role in the pathogenesis of autoimmune diabetes...
  83. doi Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells
    Vikash Chandra
    National Centre for Cell Science, Ganeshkhind, Pune, India
    Stem Cells 27:1941-53. 2009
    ..p. into streptozotocin-induced diabetic mice, restored normoglycemia within 2 weeks. The data presented here demonstrate the feasibility of using ASCs as a source of autologous stem cells to differentiate into the pancreatic lineage...
  84. pmc Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation
    Herman Blomeier
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Transplantation 82:452-9. 2006
    ..Thus, we sought to develop an approach to the extrahepatic transplantation of islets using a synthetic biodegradable polymer scaffold...
  85. doi Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets
    J Olerud
    Department of Medical Cell Biology, Uppsala University Biomedical Center, Uppsala, Sweden
    Diabetologia 52:2594-601. 2009
    ..Here we investigated whether co-transplantation of neural crest stem cells (NCSCs) with islets improves islet survival and function in normoglycaemic and diabetic mice...
  86. ncbi Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?
    W Bennet
    Department of Transplantation Surgery, Karolinska Institutet, Huddinge Hospital, Sweden
    Diabetes 48:1907-14. 1999
    ....
  87. ncbi Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?
    Niraj M Desai
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 76:1623-5. 2003
    ..0 to 3.12 for tacrolimus. Given the potential toxicity of these agents to islets, the findings in this study may have implications for designing the next generation of immunosuppressive protocols for islet transplantation...
  88. ncbi Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
    L Moberg
    Department of Radiology, Oncology, and Clinical Immunology, Division of Clinical Immunology, Rudbeck Laboratory, Uppsala, Sweden
    Lancet 360:2039-45. 2002
    ..We investigated the possible mechanism and treatment of such thrombotic reactions...
  89. pmc Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets
    Johan Olerud
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 57:1870-7. 2008
    ..The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present in islets, restricts intra-islet vascular expansion posttransplantation...
  90. ncbi Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 4:390-401. 2004
    ..Our preliminary results thus suggest that a combination of maximized viable islet yield, pretransplant islet culture, and preemptive immunosuppression can result in successful single-donor islet transplants...
  91. ncbi Five stages of evolving beta-cell dysfunction during progression to diabetes
    Gordon C Weir
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 53:S16-21. 2004
    ..For type 1 diabetes, as remission develops, progression from stage 4 to stage 2 is typically found. Delineation of these stages provides insight into the pathophysiology of both progression and remission of diabetes...
  92. ncbi Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus
    Garth L Warnock
    Department of Surgery, British Columbia Islet Transplant Centre, University of British Columbia, 950 W 10th Avenue, Vancouver, BC, Canada V5Z 4E3
    Arch Surg 140:735-44. 2005
    ..A local multiorgan donor pancreas procurement program can provide a source for optimized isolation of purified viable islets for transplantation into patients with type 1 diabetes mellitus receiving best medical therapy...
  93. ncbi Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes
    Khalid Al Ghofaili
    Department of Medicine University of British Columbia, Vancouver, BC
    Transplantation 83:24-8. 2007
    ..We evaluated the effect of exenatide on insulin secretion after islet transplantation...
  94. ncbi Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia
    Montserrat Biarnés
    Laboratory of Diabetes and Experimental Endocrinology, Endocrine Unit, CSUB Hospital de Bellvitge, University of Barcelona, Barcelona, Spain
    Diabetes 51:66-72. 2002
    ..Increased apoptosis and reduced beta-cell mass were also found in islets exposed to chronic hyperglycemia, suggesting that sustained hyperglycemia increased apoptosis in transplanted beta-cells...
  95. ncbi Interventional strategies to prevent beta-cell apoptosis in islet transplantation
    Juliet A Emamaullee
    Surgical Medical Research Institute, University of Alberta, Edmonton, AB T6G 2N8
    Diabetes 55:1907-14. 2006
    ..In addition, XIAP has enhanced long-term murine islet allograft survival. The complexities of both intrinsic and extrinsic apoptotic pathway inhibition are discussed in depth...
  96. ncbi Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes
    A N Balamurugan
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Pancreas 32:231-43. 2006
    ..All together, islet cell transplantation is moving forward...
  97. ncbi MRI of transplanted pancreatic islets
    Daniel Jirak
    Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Magn Reson Med 52:1228-33. 2004
    ..This study, therefore, represents a promising step toward possible clinical application in human medicine...
  98. ncbi Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    Takeru Matsuda
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 5:484-93. 2005
    ..These results suggest that inhibition of the p38 pathway may become a new therapeutic strategy to improve graft survival in clinical islet transplantation...
  99. ncbi Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver
    Goran Mattsson
    Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Diabetes 53:948-54. 2004
    ..The results implicate changes in islet function after intraportal transplantation. Such dysfunction may contribute to the high number of islets needed for successful transplantation in diabetic individuals...
  100. doi Oxygenation of islets and its role in transplantation
    Joey Lau
    Department of Medical Cell Biology, Uppsala University, Sweden
    Curr Opin Organ Transplant 14:688-93. 2009
    ..To summarize recent studies on the oxygenation of pancreatic islets and its role in islet transplantation...

Research Grants89

  1. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2005
    ..Studies of the mechanism of glucagon release during hypoglycemia and its disappearance in the absence of beta cells will be conducted in Sprague Dawley rats. ..
  2. Spleen regulation of beta-cell regeneration
    Anita Chong; Fiscal Year: 2007
    ..We will also test whether expression of the ligands of LT¿R, LTa¿ or LIGHT, on spleen cells and LT¿R on islet ¿-cells is critical for stimulating ¿-cell regeneration. ..
  3. Inflammation and T Cell Memory: Inter-related Barriers to Allograft Tolerance
    Terry Strom; Fiscal Year: 2007
    ..Detailed mechanistic studies will be performed and the analyses planned should provide clinically relevant information for rationally developing new tolerance strategies for not only kidney but also all allograft recipients. ..
  4. Pig to Non-Human Primate Islet Xenografts
    Judith Thomas; Fiscal Year: 2007
    ..These studies are unique and will generate new data on pig-to-NHP XPITx immunobiology and the immune mechanisms influencing development of pig XPITx tolerance. ..
  5. Donor CD8+ cell facilitates mixed chimerism in NOD mice
    Defu Zeng; Fiscal Year: 2005
    ..abstract_text> ..
  6. Improved recombinant collagenase for tissue dissociation
    Robert McCarthy; Fiscal Year: 2007
    ....
  7. IMPACT OF STANDARDIZATION AND PROCEDURE OPTIMIZATION ON*
    Ahmed Gaber; Fiscal Year: 2005
    ..This team has worked well together with the aim of curing diabetes through islet transplantation. ..
  8. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..In addition, the development of rapid, accurate, and predictive tests of islet viability and function post isolation will contribute to significant improvements in post transplant success. ..
  9. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2001
    ....
  10. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2010
    ..This will decrease the number of islets required to achieve normoglycemia in type I diabetic patients. ..
  11. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    RAM MAHATO; Fiscal Year: 2009
    ..This will decrease the number of islets required to achieve normoglycemia in type I diabetic patients. ..
  12. Parathyroid Hormone-Related Protein and the Pancreatic Beta Cell
    Rupangi Vasavada; Fiscal Year: 2009
    ....
  13. Parathyroid Hormone-Related Protein and the Pancreatic Beta Cell
    Rupangi C Vasavada; Fiscal Year: 2010
    ....
  14. Parathyroid Hormone-Related Protein and the Pancreatic Beta Cell
    Rupangi C Vasavada; Fiscal Year: 2010
    ....
  15. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2006
    ..We anticipate that the use of pre-vascularized islets as part of a composite islet-kidney transplant may provide a new and effective treatment modality for patients with class I diabetes and end-stage renal disease. ..
  16. Treg suppression of islet allograft rejection
    Zhenhua Dai; Fiscal Year: 2010
    ....
  17. REVERSAL OF DIABETES BY ISLET TRANSPLANTATION
    Ronald Gill; Fiscal Year: 1993
    ..The grafting of islet tissue from a number of different allogeneic strains to spontaneously diabetic BB rats will be used to define and investigate this problem in greater depth...
  18. B Cell immunomodulation in islet transplantation
    Ali Naji; Fiscal Year: 2006
    ..Our overall contention is that interruption of T- and B- lymphocyte function during the induction phase represents a novel and potentially powerful means of promoting immunological tolerance to islet allografts. ..
  19. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2009
    ....
  20. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2007
    ....
  21. B-Lymphocyte Immunotherapy in Islet Transplantation
    Ali Naji; Fiscal Year: 2007
    ..abstract_text> ..
  22. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..The research proposed in this grant will provide significant information to the xenotransplant research and the potential use of porcine islets as an alternative to human tissue for pancreatic islet transplantation. ..
  23. Anti-inflammatory Serpin(AAT and Elafin) Gene Transfers*
    Sihong Song; Fiscal Year: 2003
    ..abstract_text> ..
  24. Gene transfer with A20 to improve islet transplantation
    Christiane Ferran; Fiscal Year: 2003
    ..This will overcome the requirement for high numbers of islets and the need for intensive immunosuppression. Beneficial results would pave the way for pre-clinical (primates) and clinical applications. ..
  25. Commercial Feasibility Assessment of Pancreatic Islet Progenitor Cell Technology
    Kelvin Brockbank; Fiscal Year: 2007
    ....
  26. Molecularly Engineered Blockade of Islet Induced Inflammatory Responses
    Elliot Chaikof; Fiscal Year: 2010
    ....
  27. Novel SOD-mimetics for type 1 diabetes
    ELWOOD REYNOLDS; Fiscal Year: 2006
    ..The commercial goal is to develop an orally active drug which can prevent or delay onset of T1D, and/or improve the transplantation process by reducing the toxicity of immunosuppression and by increasing donor islet yield. ..
  28. Tissue Dissociation Enzymes for Islets & Other Cells
    Robert McCarthy; Fiscal Year: 2005
    ..This knowledge offers the potential to use fewer, more effective enzymes in TDE mixtures, leading to increases in the yield and quality of cells recovered from any mammalian organ. ..