dissection

Summary

Summary: The separation and isolation of tissues for surgical purposes, or for the analysis or study of their structures.

Top Publications

  1. ncbi Fiber dissection technique: lateral aspect of the brain
    U Ture
    Department of Neurosurgery, Marmara University School of Medicine, Istanbul, Turkey
    Neurosurgery 47:417-26; discussion 426-7. 2000
  2. doi Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study
    Ii Kwun Chung
    Department of Internal Medicine, Soonchunhyang University, Cheonan, Korea
    Gastrointest Endosc 69:1228-35. 2009
  3. ncbi Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006
  4. pmc Optical dissection of odor information processing in vivo using GCaMPs expressed in specified cell types of the olfactory bulb
    Matt Wachowiak
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA
    J Neurosci 33:5285-300. 2013
  5. doi Second-look endoscopy is not associated with better clinical outcomes after gastric endoscopic submucosal dissection: a prospective, randomized, clinical trial analyzed on an as-treated basis
    Ho Yoel Ryu
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
    Gastrointest Endosc 78:285-94. 2013
  6. doi Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study
    H Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Gut 58:331-6. 2009
  7. doi The feasibility of endoscopic submucosal dissection for rectal carcinoid tumors: comparison with endoscopic mucosal resection
    D S Lee
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea
    Endoscopy 42:647-51. 2010
  8. doi A second-look endoscopy after endoscopic submucosal dissection for gastric epithelial neoplasm may be unnecessary: a retrospective analysis of postendoscopic submucosal dissection bleeding
    Osamu Goto
    Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 71:241-8. 2010
  9. doi Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data
    Juan Martino
    Department of Neurosurgery, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
    Cortex 46:691-9. 2010
  10. doi A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding
    Osamu Goto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Dig Dis Sci 57:435-9. 2012

Detail Information

Publications372 found, 100 shown here

  1. ncbi Fiber dissection technique: lateral aspect of the brain
    U Ture
    Department of Neurosurgery, Marmara University School of Medicine, Istanbul, Turkey
    Neurosurgery 47:417-26; discussion 426-7. 2000
    The fiber dissection technique involves peeling away the white matter tracts of the brain to display its three-dimensional anatomic organization. Early anatomists demonstrated many tracts and fasciculi of the brain using this technique...
  2. doi Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study
    Ii Kwun Chung
    Department of Internal Medicine, Soonchunhyang University, Cheonan, Korea
    Gastrointest Endosc 69:1228-35. 2009
    The technique of endoscopic submucosal dissection (ESD) was introduced to be able to obtain en bloc specimens of large early GI neoplasms...
  3. ncbi Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer
    Shiro Oka
    Department of Endoscopy, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 64:877-83. 2006
    In EMR of early gastric cancer (EGC), en bloc resection reduces the risk of residual cancer. Endoscopic submucosal dissection (ESD) now allows en bloc resection of large EGCs.
  4. pmc Optical dissection of odor information processing in vivo using GCaMPs expressed in specified cell types of the olfactory bulb
    Matt Wachowiak
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA
    J Neurosci 33:5285-300. 2013
    ..These results suggest multiple circuit elements with distinct roles in transforming odor representations in the OB and provide a framework for further study of early olfactory processing using optical and genetic tools...
  5. doi Second-look endoscopy is not associated with better clinical outcomes after gastric endoscopic submucosal dissection: a prospective, randomized, clinical trial analyzed on an as-treated basis
    Ho Yoel Ryu
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
    Gastrointest Endosc 78:285-94. 2013
    The efficacy of routine second-look endoscopy (SLE) to detect or prevent bleeding after gastric endoscopic submucosal dissection (ESD) has not yet been validated.
  6. doi Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study
    H Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Gut 58:331-6. 2009
    Endoscopic submucosal dissection (ESD) has the advantage over conventional endoscopic mucosa resection, permitting removal of early gastric cancer (EGC) en bloc, but long-term clinical outcomes remain unknown...
  7. doi The feasibility of endoscopic submucosal dissection for rectal carcinoid tumors: comparison with endoscopic mucosal resection
    D S Lee
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea
    Endoscopy 42:647-51. 2010
    ..This study aimed to compare the safety and efficacy of endoscopic submucosal dissection (ESD) with endoscopic mucosal resection (EMR) for rectal carcinoid tumors.
  8. doi A second-look endoscopy after endoscopic submucosal dissection for gastric epithelial neoplasm may be unnecessary: a retrospective analysis of postendoscopic submucosal dissection bleeding
    Osamu Goto
    Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 71:241-8. 2010
    Endoscopic submucosal dissection (ESD) is one of the curative endoluminal surgical procedures for gastric epithelial neoplasms. There has been little research on bleeding after gastric ESD.
  9. doi Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data
    Juan Martino
    Department of Neurosurgery, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
    Cortex 46:691-9. 2010
    ..the lights of these new functional data, we dissected 14 post-mortem human hemispheres using the Klingler fiber dissection technique, to study the IFOF fibers and to identify their actual cortical terminations in the parietal, ..
  10. doi A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding
    Osamu Goto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Dig Dis Sci 57:435-9. 2012
    Bleeding is a major complication after gastric endoscopic submucosal dissection (ESD). An evidence-based strategy for postoperative care related to delayed bleeding is required...
  11. ncbi Student responses to the gross anatomy laboratory in a medical curriculum
    C E Dinsmore
    Department of Anatomy, Rush Medical College, Chicago, Illinois, USA
    Clin Anat 14:231-6. 2001
    Working with cadavers, whether through active dissection or by examination of prosected specimens, constitutes a potential stressor in medical education although there is no consensus on its effect...
  12. ncbi Efficacy of propofol sedation for endoscopic submucosal dissection (ESD): assessment with prospective data collection
    Taku Yamagata
    Department of Gastroenterology, Sendai City Medical Center, Japan
    Intern Med 50:1455-60. 2011
    ..of the digestive tract are expanding with the emergence and technical development of endoscopic submucosal dissection (ESD)...
  13. doi Risk factors and prognosis of pulmonary complications after endoscopic submucosal dissection for gastric neoplasia
    Chan Hyuk Park
    Institute of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun gu, Seoul, 120 752, Republic of Korea
    Dig Dis Sci 58:540-6. 2013
    Hospital-acquired pneumonia after an endoscopic submucosal dissection (ESD) can prolong the patient's stay in the hospital, leading to greater healthcare costs...
  14. doi Routine coagulation of visible vessels may prevent delayed bleeding after endoscopic submucosal dissection--an analysis of risk factors
    K Takizawa
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Endoscopy 40:179-83. 2008
    Endoscopic submucosal dissection (ESD) has been reported to be associated with a higher complication rate than standard endoscopic mucosal resection...
  15. doi Risk factors for bleeding after endoscopic submucosal dissection of gastric epithelial neoplasm
    Makoto Higashiyama
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Dig Endosc 23:290-5. 2011
    Although endoscopic submucosal dissection (ESD) is standard therapy in Japan for gastric epithelial neoplasm, the complication rate is unsatisfactory, with postoperative bleeding as the major complication...
  16. pmc Efficacy and safety of over-the-scope clip: including complications after endoscopic submucosal dissection
    Noriko Nishiyama
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0796, Japan
    World J Gastroenterol 19:2752-60. 2013
    To retrospectively review the results of over-the-scope clip (OTSC) use in our hospital and to examine the feasibility of using the OTSC to treat perforations after endoscopic submucosal dissection (ESD).
  17. ncbi White matter fiber dissection of the optic radiations of the temporal lobe and implications for surgical approaches to the temporal horn
    Eric H Sincoff
    Cerebrovascular and Skull Base Surgery Program, Division of Neurosurgery, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 101:739-46. 2004
    ..and the temporal horn and superficial anatomy of the temporal lobe by using the Klingler white matter fiber dissection technique. These findings were correlated with established surgical trajectories to the temporal horn...
  18. doi Technical feasibility of endoscopic submucosal dissection for early gastric cancer in patients taking anti-coagulants or anti-platelet agents
    S Ono
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo, Tokyo 113 8655, Japan
    Dig Liver Dis 41:725-8. 2009
    Endoscopic submucosal dissection is a novel technique that is expected to be a curative treatment for early gastric cancers...
  19. doi Endoscopic submucosal dissection for treatment of gastric subepithelial tumors (with video)
    Andrzej Białek
    Gastroenterology Department, Pomeranian Medical University, Szczecin, Poland
    Gastrointest Endosc 75:276-86. 2012
    Endoscopic submucosal dissection (ESD) is a well-accepted method for removing superficial mucosal tumors; however, there is limited data on the use of this method for removing subepithelial tumors.
  20. doi Outcome of endoscopic submucosal dissection for colorectal tumors accompanied by fibrosis
    Aki Matsumoto
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Minami Ku, Hiroshima, Japan
    Scand J Gastroenterol 45:1329-37. 2010
    Colorectal endoscopic submucosal dissection (ESD) is a difficult procedure. We aimed to retrospectively assess the relationship between the outcome of ESD for colorectal tumors and the degree of fibrosis.
  21. doi Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets
    Takeshi Ohki
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Gastroenterology 143:582-8.e1-2. 2012
    The use of esophageal endoscopic submucosal dissection (ESD) to remove superficial esophageal neoplasms is gradually becoming more common in Japan...
  22. doi Endoscopic submucosal dissection is an effective and safe therapy for early gastric neoplasms: a multicenter feasible study
    Takafumi Sugimoto
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 46:124-9. 2012
    The technique of endoscopic submucosal dissection (ESD) was introduced to obtain en bloc specimens of large early gastrointestinal neoplasms...
  23. doi The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection
    Satoru Hashimoto
    Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan
    Gastrointest Endosc 74:1389-93. 2011
    Use of endoscopic submucosal dissection (ESD) for management of widespread superficial esophageal carcinomas may be complicated by the development of severe strictures, which may require serial treatment with endoscopic balloon dilatation ..
  24. doi Current status of colorectal endoscopic submucosal dissection in Japan and other Asian countries: progressing towards technical standardization
    Yutaka Saito
    National Cancer Center Hospital, Tokyo, Japan
    Dig Endosc 24:67-72. 2012
    ..of this questionnaire survey study was to determine the current status of colorectal endoscopic submucosal dissection (ESD) in specialized Japanese referral centers before and after introduction of a government-approved advanced ..
  25. doi Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Gastroenterol 43:641-51. 2008
    Endoscopic submucosal dissection (ESD) allows en bloc resection of a lesion, irrespective of the size of the lesion...
  26. doi Endoscopic submucosal dissection in large sessile lesions of the rectosigmoid: learning curve in a European center
    A Probst
    Department of Gastroenterology, Klinikum Augsburg, Stenglinstrasse 2, Augsburg, Germany
    Endoscopy 44:660-7. 2012
    Endoscopic submucosal dissection (ESD) in the colorectum is not currently a standard procedure. Few data are available from the Western world...
  27. ncbi Achieving R0 resection in the colorectum using endoscopic submucosal dissection
    D P Hurlstone
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
    Br J Surg 94:1536-42. 2007
    ..Endoscopic submucosal dissection (ESD) enables en bloc resection of lesions larger than 20 mm...
  28. doi Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection
    Yutaka Saito
    Endoscopy Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Surg Endosc 24:343-52. 2010
    Endoscopic submucosal dissection (ESD) has recently been applied to the treatment of superficial colorectal cancer...
  29. doi Current status and future perspectives of endoscopic submucosal dissection for colorectal tumors
    Shinji Tanaka
    Department of Endoscopy Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 24:73-9. 2012
    Endoscopic submucosal dissection (ESD) allows for en bloc tumor resection irrespective of the size of the lesion...
  30. doi Retrospective study of technical aspects and complications of endoscopic submucosal dissection for laterally spreading tumors of the colorectum
    T Toyonaga
    Department of Endoscopy, Kobe University Hospital, Kobe, Japan
    Endoscopy 42:714-22. 2010
    ..spreading tumors - non granular type (LST-NG) are more often considered candidates for endoscopic submucosal dissection (ESD) than laterally spreading tumors - granular type (LST-G), because of their higher potential for submucosal ..
  31. pmc Endoscopic submucosal dissection training with pig models in a Western country
    Adolfo Parra-Blanco
    Department of Gastroenterology, University Hospital of the Canary Islands, Ofra s n, La Laguna, 38320 Tenerife, Spain
    World J Gastroenterol 16:2895-900. 2010
    To test a strategy for endoscopic submucosal dissection (ESD) training in animal models designed to overcome the initial learning curve.
  32. ncbi Teaching anatomy without cadavers
    John C McLachlan
    Peninsula Medical School, University of Plymouth, C306 Portland Square, Drake Circus, Plymouth PL4 8AA, UK
    Med Educ 38:418-24. 2004
    ..Anatomy learning is generally seen as essential to medicine, and exposure to cadavers is generally seen as essential to anatomy learning around the world. Few voices dissenting from these propositions can be identified...
  33. doi Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video)
    Quan lin Li
    Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China
    Gastrointest Endosc 75:1153-8. 2012
    ..Endoscopic submucosal dissection (ESD) has been used successfully for the removal of esophageal or gastric SMTs; however, the EGJ has been ..
  34. doi Factors predictive of perforation during endoscopic submucosal dissection for the treatment of colorectal tumors
    E S Kim
    Department of Internal Medicine, Institute of Gastroenterology and Hepatology, Keimyung University School of Medicine, Daegu, South Korea
    Endoscopy 43:573-8. 2011
    Although perforation of the colon is known as one of the main complications of endoscopic submucosal dissection (ESD) for colorectal tumor management, factors predictive of perforation have not been fully evaluated...
  35. pmc Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions
    Yosuke Tsuji
    Department of Gastroenterology, Kanto Medical Center, NTT EC, 5 9 22 Higashi Gotanda, Shinagawa ku, Tokyo 141 8625, Japan
    World J Gastroenterol 16:2913-7. 2010
    To assess risk factors for bleeding after gastric endoscopic submucosal dissection (ESD) and to develop preventive measures.
  36. ncbi Xenomonitoring of Wuchereria bancrofti and Dirofilaria immitis infections in mosquitoes from American Samoa: trapping considerations and a comparison of polymerase chain reaction assays with dissection
    Eric W Chambers
    Atlanta Research and Education Foundation, Decatur, Georgia, USA
    Am J Trop Med Hyg 80:774-81. 2009
    ..Hemalum staining and dissection and polymerase chain reaction (PCR) were compared to determine the filarial infection status of Aedes (Stegomyia)..
  37. doi Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract
    Y Cao
    Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People s Republic of China
    Endoscopy 41:751-7. 2009
    Endoscopic submucosal dissection (ESD) has been developed to overcome the limitations of endoscopic mucosal resection (EMR). We aimed to compare the outcomes of these two methods.
  38. doi Ex vivo pig training model for esophageal endoscopic submucosal dissection (ESD) for endoscopists with experience in gastric ESD
    Shinwa Tanaka
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7 5 1 Chu o ku, Kusunoki cho, Kobe, Hyogo 650 0017, Japan
    Surg Endosc 26:1579-86. 2012
    Esophageal endoscopic submucosal dissection (ESD) has developed in recent years because of its high rate of en bloc resection...
  39. ncbi Ultrasound-guided blocks of the ilioinguinal and iliohypogastric nerve: accuracy of a selective new technique confirmed by anatomical dissection
    U Eichenberger
    Department of Anaesthesia and General Intensive Care B, Medical University of Vienna, A 1090 Vienna, Austria
    Br J Anaesth 97:238-43. 2006
    ..This study describes a new ultrasound-guided approach to these nerves and determines its accuracy using anatomical dissection control.
  40. ncbi MR imaging of the temporal stem: anatomic dissection tractography of the uncinate fasciculus, inferior occipitofrontal fasciculus, and Meyer's loop of the optic radiation
    E Leon Kier
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520 8042, USA
    AJNR Am J Neuroradiol 25:677-91. 2004
    ..The purpose of this investigation was to study these structures in the anterior temporal lobe and the external and extreme capsules and to correlate the dissected anatomy with the cross-sectional MR anatomy...
  41. doi Risk factors for delayed bleeding after endoscopic submucosal dissection for gastric neoplasm
    Kazuhisa Okada
    Division of Endoscopy, Cancer Institute Hospital, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Surg Endosc 25:98-107. 2011
    Delayed bleeding is one of the major complications of endoscopic submucosal dissection (ESD)...
  42. ncbi Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resection
    Kenichiro Watanabe
    Department of Internal Medicine, Radiology, Pathology, Saga Prefectural Hospital Koseikan, Saga Japan
    Gastrointest Endosc 63:776-82. 2006
    EMR is currently a standard treatment for mucosal gastric tumors. Endoscopic submucosal dissection (ESD) has been developed for en bloc resection.
  43. ncbi Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Gastrointest Endosc 66:100-7. 2007
    Endoscopic submucosal dissection (ESD) has been positively applied to and gradually standardized for early stomach cancer, particularly in Japan...
  44. ncbi Outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms in 200 consecutive cases
    Mitsuhiro Fujishiro
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 5:678-83; quiz 645. 2007
    The clinical outcomes for endoscopic submucosal dissection (ESD), a novel endoluminal surgery for gastrointestinal neoplasm in the colorectum, are reported.
  45. doi Predictors of immediate bleeding during endoscopic submucosal dissection in gastric lesions
    Seong Woo Jeon
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, 50 Samduk 2 Ga, Chung gu, Daegu, 700 721, South Korea
    Surg Endosc 23:1974-9. 2009
    ..resection for a gastric neoplasm, little is known about the predictors of complications of endoscopic submucosal dissection (ESD)...
  46. doi Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection
    S Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 2608670, Japan
    Endoscopy 41:746-50. 2009
    Endoscopic submucosal dissection (ESD) has been reported to produce excellent treatment results for early gastric cancer...
  47. doi Endoscopic submucosal dissection for treatment of rectal carcinoid tumors
    Hye Won Park
    Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Gastrointest Endosc 72:143-9. 2010
    ..Endoscopic submucosal dissection (ESD), a new method for large colorectal neoplasm resection, may overcome this problem.
  48. ncbi Endoscopic submucosal dissection allows curative resection of locally recurrent early gastric cancer after prior endoscopic mucosal resection
    Chizu Yokoi
    Department of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    Gastrointest Endosc 64:212-8. 2006
    ..EMR) to cure locally recurrent early gastric cancer (EGC) is difficult to perform because the initial EMR causes submucosal fibrosis; however, ESD allows submucosal dissection through the fibrosis and provides an en bloc specimen.
  49. ncbi Deep lamellar keratoplasty by intracorneal dissection: a prospective clinical and confocal microscopic study
    Giorgio Marchini
    Eye Clinic, Department of Neurological and Visual Sciences, University of Verona, Verona, Italy
    Ophthalmology 113:1289-300. 2006
    ..To evaluate the clinical findings, visual outcomes, and confocal microscopic corneal features of a surgical technique for manual deep lamellar keratoplasty (DLKP) with intentional sparing of the most posterior stroma...
  50. ncbi Characterisation of guinea pig precision-cut lung slices: comparison with human tissues
    A R Ressmeyer
    Research Center Borstel, Borstel, Germany
    Eur Respir J 28:603-11. 2006
    ..6 nM (airway). When compared with previous findings in rat and mouse, these data show that guinea pig lungs are a more appropriate model for human airway pharmacology than lungs from rats or mice...
  51. doi Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms
    Satoshi Ono
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 70:860-6. 2009
    The long-term outcomes of endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell neoplasms (ESCNs) have not been evaluated to date.
  52. doi Endoscopic submucosal dissection (ESD) for colorectal tumors
    Yutaka Saito
    National Cancer Center Hospital, Tokyo, Japan
    Dig Endosc 21:S7-12. 2009
    Endoscopic submucosal dissection (ESD) is accepted as a minimally invasive treatment for early gastric cancer, however, it is not widely used in the colorectum because of its technical difficulty.
  53. pmc Management of esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    BMC Gastroenterol 11:46. 2011
    Endoscopic submucosal dissection (ESD) permits removal of esophageal epithelial neoplasms en bloc, but is associated with esophageal stenosis, particularly when ESD involves the entire circumference of the esophageal lumen...
  54. doi A feasibility study on the expanded indication for endoscopic submucosal dissection of early gastric cancer
    Hyuk Lee
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Surg Endosc 25:1985-93. 2011
    Endoscopic submucosal dissection (ESD) is the standard treatment for selected cases of early gastric cancer (EGC). Evolution of ESD techniques and accessories has expanded treatment indications...
  55. pmc The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection
    Toshihisa Takeuchi
    2nd Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Osaka, Japan
    BMC Gastroenterol 13:136. 2013
    ..the risk of postoperative hemorrhage in patients on antithrombotic therapy who undergo endoscopic submucosal dissection (ESD)...
  56. ncbi Management of spontaneous coronary artery dissection in the primary percutaneous coronary intervention era
    David Adlam
    Oxford Heart Centre, John Radcliffe Hospital, OX3 9DU, Oxford, United Kingdom
    J Invasive Cardiol 22:549-53. 2010
    Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndromes...
  57. doi Recommended sedation and intraprocedural monitoring for gastric endoscopic submucosal dissection
    Tohru Sasaki
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan
    Dig Endosc 25:79-85. 2013
    Endoscopic submucosal dissection is associated with a longer treatment time and a higher risk of patient discomfort than conventional procedures. Adequate, safe sedation is therefore essential...
  58. doi Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia
    Chan Hyuk Park
    Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, Republic of Korea
    Surg Endosc 27:2760-7. 2013
    Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection (ESD), there is no research investigating the effects of sedation on ESD performance and complications...
  59. doi Comparison of endoscopic resection therapies for rectal carcinoid tumor: endoscopic submucosal dissection versus endoscopic mucosal resection using band ligation
    Cheol W Choi
    Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea
    J Clin Gastroenterol 47:432-6. 2013
    ..Endoscopic submucosal dissection (ESD) may cause more severe complications, longer operation time, and higher cost than EMR.
  60. doi Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial
    T Sasaki
    Department of Gastroenterology, Kitasato University School of Medicine, Kanagawa, Japan
    Endoscopy 44:584-9. 2012
    Endoscopic submucosal dissection (ESD) has become a standard treatment. However, the treatment time tends to be relatively long and insufflation and manipulation of the endoscope can increase pain and discomfort...
  61. doi Extra-capsular dissection in benign parotid tumors
    Luigi Barzan
    Otolaryngology, Azienda Ospedaliera S Maria degli Angeli, Pordenone, Italy
    Oral Oncol 48:977-9. 2012
    ..tumors is still lacking of general consensus: this retrospective study, from 1964 to 2004 with a minimum follow-up of 7 years, is carried out with the aim to evaluate the results of parotidectomy and extracapsular dissection (ECD).
  62. doi Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle
    Silvio Sarubbo
    Division of Neurosurgery, Department of Neurosciences and Rehabilitation, S Anna University Hospital, 203 C so della Giovecca, 44100 Ferrara, Italy
    Brain Struct Funct 218:21-37. 2013
    ..Ten hemispheres (5 left, 5 right) were dissected with Klingler's technique. In addition to the IFOF dissection, we performed a 4-T diffusion tensor imaging study on a single healthy subject. We identified two layers of IFOF...
  63. doi Risk factors for delayed bleeding from endoscopic submucosal dissection of gastric neoplasms
    Munetaka Nakamura
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Scand J Gastroenterol 47:1108-14. 2012
    Delayed bleeding is a major complication of endoscopic submucosal dissection (ESD) of gastric neoplasms. We aimed to clarify risk factors for delayed bleeding from ESD.
  64. ncbi Quidne mortui vivos docent? The evolving purpose of human dissection in medical education
    G S Dyer
    Department of Social Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Acad Med 75:969-79. 2000
    The dissection experience has evolved over the past 500 years, following broader cutural trends in science and medicine. Through this time each period has recruited human gross anatomic dissection for characteristic purposes...
  65. doi Factors predicting perforation during endoscopic submucosal dissection for gastric cancer
    Takashi Ohta
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Gastrointest Endosc 75:1159-65. 2012
    Perforation is a common complication of endoscopic submucosal dissection (ESD), but little is known about the relevant risk factors.
  66. doi Current opinions for endoscopic submucosal dissection for colorectal tumors from our experiences: indications, technical aspects and complications
    Kinichi Hotta
    Division of Endoscopy and Gastrointestinal Oncology, Shizuoka, Japan
    Dig Endosc 24:110-6. 2012
    Endoscopic submucosal dissection (ESD) was first applied in the resection of large colorectal tumors 10 years ago...
  67. doi Superficial adenocarcinoma of the esophagogastric junction: long-term results of endoscopic submucosal dissection
    Kingo Hirasawa
    Gastroenterological Center and Department of Pathology, Yokohama City University Medical Center, Minami Ku, Yokohama, Japan
    Gastrointest Endosc 72:960-6. 2010
    Endoscopic submucosal dissection (ESD) was recently introduced as a treatment option for superficial adenocarcinoma of the esophagogastric junction (EGJ); however, its long-term clinical outcomes have not been fully evaluated.
  68. pmc Psychological stress in first year medical students in response to the dissection of a human corpse
    Veronika Bernhardt
    Sana Ohre Klinikum, Haldensleben, Germany
    GMS Z Med Ausbild 29:Doc12. 2012
    ..In October 2007 186 students started the dissection course at Otto-von-Guericke-University Magdeburg...
  69. pmc Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy
    Shinji Tanaka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 25:107-16. 2013
    ..In contrast, endoscopic submucosal dissection (ESD) is indicated for lesions requiring endoscopic en bloc excision, as it is difficult to use the snare ..
  70. doi Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia: a multicenter study by Osaka University ESD Study Group
    Motohiko Kato
    Department of Gastroenterology and Hepatology, Clinical Research Building K1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gastroenterol 46:325-31. 2011
    Treatment with endoscopic submucosal dissection (ESD) for gastric noninvasive neoplasia (NIN) diagnosed by endoscopic forceps biopsy specimen, whether as a follow-up or "total incisional biopsy", is controversial...
  71. pmc The potential for non-invasive study of mummies: validation of the use of computerized tomography by post factum dissection and histological examination of a 17th century female Korean mummy
    Do Seon Lim
    Department of Dental Hygiene, College of Health Science, Eulji University, Sungnam, Korea
    J Anat 213:482-95. 2008
    ..of some descendants with regard to invasive examinations of age-old human remains make permission for dissection of Korean mummies of the Joseon Dynasty (1392-1910) difficult to obtain...
  72. doi Effect of head position and surgical dissection on sinus irrigant penetration in cadavers
    Deepti Singhal
    Department of Surgery Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, South Australia
    Laryngoscope 120:2528-31. 2010
    ..Effective treatment for recalcitrant rhinosinusitis requires unobstructed surgical marsupialization of sinus cavities and use of delivery systems that will topically penetrate the sinuses...
  73. doi Can endoscopic submucosal dissection technique be an alternative treatment option for a difficult giant (≥ 30 mm) pedunculated colorectal polyp?
    Yong Sung Choi
    Department of Gastroenterology, Daehang Hospital, Seoul, Korea
    Dis Colon Rectum 56:660-6. 2013
    ..Snare polypectomy of a giant pedunculated colorectal polyp is sometimes technically demanding, and, therefore, piecemeal resection is inevitable, despite the relative risk of invasive cancer and postpolypectomy bleeding...
  74. ncbi Endoscopic submucosal dissection: a safe technique for colorectal tumors
    Y Tamegai
    Department of Gastroenterology, International Medical Center of Japan, Tokyo, Japan
    Endoscopy 39:418-22. 2007
    Endoscopic submucosal dissection (ESD) aims to resect large neoplastic lesions en bloc, allowing for more precise histopathological analysis...
  75. doi New insights into the anatomic dissection of the temporal stem with special emphasis on the inferior fronto-occipital fasciculus: implications in surgical approach to left mesiotemporal and temporoinsular structures
    Juan Martino
    Department of Neurosurgery, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
    Neurosurgery 66:4-12. 2010
    To analyze the 3-dimensional relationships of the inferior fronto-occipital fasciculus (IFOF) within the temporal stem using anatomic dissection and to study the surgical application.
  76. doi Simulating a target lesion for endoscopic submucosal dissection training in an ex vivo pig model
    Tsang En Wang
    Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital and Mackay Medicine Nursing and Management College, Taipei, Taiwan
    Gastrointest Endosc 74:398-402. 2011
    Currently, there is no training model that simulates the target lesion encountered during endoscopic submucosal dissection.
  77. doi Endoscopic submucosal dissection in a European setting. A multi-institutional report of a technique in development
    S Farhat
    Hopital Cochin, Paris
    Endoscopy 43:664-70. 2011
    Endoscopic submucosal dissection (ESD) is a technique for "en bloc" resection of superficial tumors of the gastrointestinal tract. In France, experience with this technique is still limited...
  78. doi Colorectal endoscopic submucosal dissection for elderly patients at least 80 years of age
    Toshio Uraoka
    Department of Endoscopy, Okayama University Hospital, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Surg Endosc 25:3000-7. 2011
    Endoscopic submucosal dissection (ESD) has been used recently for successful en bloc resection of even large lesions, although no consensus appears in medical literature concerning its application to elderly patients...
  79. doi Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)
    Hiroaki Takahashi
    Department of Gastroenterology, Keiyukai Sapporo Hospital, Sapporo, Japan
    Gastrointest Endosc 72:255-64, 264.e1-2. 2010
    Endoscopic submucosal dissection (ESD) was originally developed in Japan for en bloc resection of gastric neoplasms.
  80. doi Connection between the spinal dura mater and suboccipital musculature: evidence for the myodural bridge and a route for its dissection--a review
    Kourosh Kahkeshani
    Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia 24901, USA
    Clin Anat 25:415-22. 2012
    ..rectus capitis posterior minor muscle was first described in 1995 and has since been readily demonstrated via dissection, magnetic resonance imaging, and plastinated cross-sections of the upper cervical region (Hack et al...
  81. ncbi Efficacy and safety of endoscopic submucosal dissection for gastric cancer in patients with liver cirrhosis
    K Ogura
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Endoscopy 40:443-5. 2008
    Endoscopic submucosal dissection (ESD) has become a widely accepted method for treating gastrointestinal cancer. The aim of this study was to evaluate the efficacy and safety of ESD for gastric cancer in patients with liver cirrhosis...
  82. doi Efficacy of novel SB knife Jr examined in a multicenter study on colorectal endoscopic submucosal dissection
    Kiyoaki Homma
    Department of Therapeutic Endoscopy, Nihonkai General Hospital, Yamagata, Japan
    Dig Endosc 24:117-20. 2012
    Secure manipulation of forceps in endoscopic submucosal dissection (ESD) for colorectal tumors is sometimes hindered by the characteristics of that organ...
  83. ncbi Endoscopic submucosal dissection for early gastric cancer
    Hiroyuki Ono
    Endoscopy and GI Oncology Division, Shizuoka Cancer Center Hospital, Shizuoka, Japan
    Chin J Dig Dis 6:119-21. 2005
    ..This knife can cut submucosa safely and remove a lesion completely. We named this method endoscopic submucosal dissection (ESD). Using this procedure, 96% of the tumors (471/488) were completely resected in one piece...
  84. doi Comparison of the femtosecond laser (IntraLase) versus manual microkeratome (Moria ALTK) in dissection of the donor in endothelial keratoplasty: initial study in eye bank eyes
    Yian Jin Jones
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Cornea 27:88-93. 2008
    ..To determine the safety and efficacy of a femtosecond laser (IntraLase) and manual microkeratome (Moria ALTK) in creating precut endothelial keratoplasty donor tissue...
  85. doi Endoscopic Doppler US for the prevention of ulcer bleeding after endoscopic submucosal dissection for early gastric cancer: a preliminary study (with video)
    Noriya Uedo
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Gastrointest Endosc 72:444-8. 2010
    After endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), delayed bleeding occurs in 1.7% to 38% of cases...
  86. ncbi The role of three-dimensional information in health care and medical education: the implications for anatomy and dissection
    S C Marks
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA
    Clin Anat 13:448-52. 2000
    ..health care, anatomical societies need to provide answers to the following questions: Do the opportunities of dissection (visual, tactile, time, discovery, group process, mentoring) contribute to short- and long-term learning of 3-D ..
  87. doi Endoscopic submucosal dissection for treatment of mesopharyngeal and hypopharyngeal carcinomas
    T Iizuka
    Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
    Endoscopy 41:113-7. 2009
    Application of the endoscopic submucosal dissection (ESD) technique, as well as elevation of the larynx in cooperation with an otolaryngologist, under general anesthesia has enabled en-block resection of early mesopharyngeal and ..
  88. doi Clinical risk factors for perforation during endoscopic submucosal dissection (ESD) for large-sized, nonpedunculated colorectal tumors
    Eun Jung Lee
    Department of Surgery, Daehang Hospital, Bangbae 3dong Seocho gu, Seoul 137 820, Korea
    Surg Endosc 26:1587-94. 2012
    The possible risk of colonic perforation during endoscopic submucosal dissection (ESD) for colorectal tumors is a barrier to wide application...
  89. doi Comparison of endoscopic submucosal dissection and endoscopic mucosal resection for large colorectal tumors
    Masahiro Tajika
    Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan
    Eur J Gastroenterol Hepatol 23:1042-9. 2011
    ..Endoscopic submucosal dissection (ESD) can be performed for resection of larger tumors, but has not been studied in the colorectum because of ..
  90. ncbi Spontaneous coronary artery dissection: the clinical spectrum
    Rajiv Dhawan
    Department of Cardiology, Geisinger Medical Center, Danville, PA, USA
    Angiology 53:89-93. 2002
    Spontaneous coronary artery dissection is a rare but increasingly reported cause of myocardial ischemia and sudden death. It is more commonly seen in younger age groups and has a predilection for postpartum women...
  91. doi Submucosal tunneling using endoscopic submucosal dissection for peritoneal access and closure in natural orifice transluminal endoscopic surgery: a porcine survival study
    F Yoshizumi
    Department of Gastroenterological Surgery, Oita University Faculty of Medicine, Yufu, Oita, Japan
    Endoscopy 41:707-11. 2009
    ..We aimed to clarify the feasibility of a submucosal tunnel technique using endoscopic submucosal dissection (ESD) for transgastric peritoneal access and subsequent closure for NOTES.
  92. ncbi Does intrafascial dissection during nerve-sparing laparoscopic radical prostatectomy compromise cancer control?
    Mischel G Neill
    Royal Surrey County Hospital, Guildford, Surrey, UK
    BJU Int 104:1730-3. 2009
    To assess whether oncological outcomes are compromised by adopting the curtain dissection (CD) technique (high incision of the peri-prostatic fascia) during nerve-preserving radical prostatectomy (RP).
  93. doi Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques
    Abhidha Shah
    Department of Neurosurgery, Seth G S Medical College and King Edward VII Memorial Hospital, Acharya Donde Marg, Parel, Mumbai 400012, India
    J Clin Neurosci 19:289-98. 2012
    Fiber dissection techniques were used to study the limbic system, in particular the Papez circuit. The course, length and anatomical relations of the structures that make up the Papez circuit were delineated...
  94. doi Risk factors for immediate and delayed bleeding associated with endoscopic submucosal dissection of gastric neoplastic lesions
    Jin Seok Jang
    Department of Internal Medicine, Dong A Medical Center, University College of Medicine, Busan, Korea
    Scand J Gastroenterol 44:1370-6. 2009
    OBJECTIVE. Endoscopic submucosal dissection (ESD) of gastric neoplasia has been reported to have a higher bleeding rate than conventional endoscopic mucosal resection (EMR)...
  95. doi Endoscopic submucosal dissection for treatment of esophageal submucosal tumors originating from the muscularis propria layer
    Qiang Shi
    Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China
    Gastrointest Endosc 74:1194-200. 2011
    The technique of endoscopic submucosal dissection (ESD), which was developed for en bloc resection of large lesions in the stomach, has been widely accepted for the treatment of early gastric cancer...
  96. ncbi A dissection and computer tomograph study of tarsal coalitions in 100 cadaver feet
    L B Solomon
    Department of Orthopaedics, Alice Springs Hospital, Flinders University School of Medicine, P O Box 2234, Alice Springs, NT 0871, Australia
    J Orthop Res 21:352-8. 2003
    ..There was correlation between dissection and CT in two talocalcaneal coalitions and three calcaneonavicular coalitions thus CT identifying 55...
  97. ncbi Posterior cruciate ligament architecture: evaluation under microsurgical dissection
    C A Makris
    Department of Orthopaedic Surgery, University of Ioannina Medical School, Ioannina, Greece
    Arthroscopy 16:627-32. 2000
    ..PCL) and to measure the main dimensions and the femoral and tibial attachment site distances of the ligament after microsurgical dissection. We hypothesized that PCL anatomy is more complex than the 2 traditionally characterized bands.
  98. doi Usefulness and safety of SB knife Jr in endoscopic submucosal dissection for colorectal tumors
    Shiro Oka
    Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
    Dig Endosc 24:90-5. 2012
    Use of a Dual knife has become commonplace for endoscopic submucosal dissection (ESD) of colorectal tumors at Hiroshima University Hosipital...
  99. doi A new technique for gastric endoscopic submucosal dissection: peroral traction-assisted endoscopic submucosal dissection
    Won Joong Jeon
    Department of Internal Medicine, Chungbuk National University, College of Medicine and Medical Research Institute, Hungdukgu, Cheongju, Korea
    Gastrointest Endosc 69:29-33. 2009
    Compared with conventional EMR, endoscopic submucosal dissection (ESD) has a higher en bloc resection rate and complete resection rate, regardless of tumor size, in treating gastric neoplasms...
  100. doi Endoscopic submucosal dissection for large colorectal tumors using a cross-counter technique and a novel large-diameter balloon overtube
    Koichi Okamoto
    Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    Dig Endosc 24:96-9. 2012
    Endoscopic submucosal dissection (ESD) in early gastric cancer (EGC), which provides a higher complete resection rate than conventional endoscopic mucosal resection (EMR), has rapidly come into widespread use...
  101. doi Current practice with endoscopic submucosal dissection in Europe: position statement from a panel of experts
    P H Deprez
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Av Hippocrate 10, Brussels, Belgium
    Endoscopy 42:853-8. 2010
    Endoscopic submucosal dissection (ESD) is the gold standard technique for performing en bloc resection of large superficial tumors in the upper and lower gastrointestinal tract...

Research Grants76

  1. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Q-RT-PCR using amplified (a)RNA from laser capture micro-dissection (LCM)-isolated AECs and non(n)-AEC cells from sham, HS and HS/I rat lungs revealed: 1) that the assignment of ..
  2. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..The findings from the ivGTT will allow for the dissection of the respective roles of improvements in SI and AIRg on diabetes risk...
  3. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..ChIP) assays to scan for candidate VDREs, plus DNA gel mobility shift, real time PCR and promoter dissection to identify VDR-controlled genes...
  4. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..Identification of the proteins recruited to the PRLR-JAK2 and dissection of the signaling pathways that are subsequently activated will ultimately provide a basis for understanding PRL ..
  5. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..We have generated several genetic models that facilitate careful mechanistic dissection of the cell-lineage specific importance of TH2 associated gene expression...
  6. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..Proteomics is a powerful state-of-the-art strategy in genetic dissection of complex diseases, such as osteoporosis...
  7. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..pathways play a major role in human autoimmune, inflammatory and malignant disease, a more complete in vivo dissection of SHP-1 regulated signaling will help guide therapeutic development...
  8. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..use techniques of behavioral observation and quantitation before and after injections of agents of interest, CNS dissection, immunohistochemistry, confocal microscopy, hemolymph sampling and quantitative mass spectrometry...
  9. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..Change Topic, 06- HL-101 "Developing technologies for assessment of aortic aneurysms prone to rupture or dissection". Aortic dissection describes a tear in the wall of the main vessel in the body, the aorta...
  10. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..The goal of this Project is to initiate a dissection of these mechanisms by new mass spectrometry-based methodologies to identify and characterize proteomic ..
  11. Molecular Determinants of DNA Sliding and Hopping by a DNA Repair Glycosylase
    MENG MENG ROWLAND; Fiscal Year: 2013
    ..trap to capture transient hopping enzymes while having minimal effect on the sliding ones, thus allowing the dissection of the two tracking pathways individually...
  12. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..Drosophila melanogaster spermatogenesis is an ideal model system for genetic dissection of conserved mechanisms of mitochondrial morphogenesis, since mitochondria undergo dramatic shaping during sperm ..
  13. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven A Fisher; Fiscal Year: 2013
    ..Aim 3: Tra2b as a novel nodal point for the dissection of VSM diversification...
  14. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    ..between the potential for calcification by mitral and aortic VICs (Aim 1) using laser capture micro-dissection and osteogenic gene analysis of porcine valve tissues and by treating cultured porcine VICs with LPC...
  15. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
    ..wall with a diameter greater than 50% of normal, is an inflammatory disease of the aorta that can result in dissection of the wall, formation of an intramural clot, and rupture of th aorta resulting in almost immediate death in the ..
  16. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2013
    ..understanding E2 function using virus-neutralizing antibodies and genetic approaches, more in-depth mechanistic dissection of E2 requires complementary biochemical, biophysical and molecular virology techniques...
  17. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
    ..By genetic dissection, we will analyze the molecular basis of b,b-carotene absorption and conversion into retinoids and the regulation ..
  18. Angiotensin II uncoupling of eNOS in hypertension
    HUA LINDA CAI; Fiscal Year: 2013
    ..Ultrasound monitoring of abdominal aorta diameter in the survived mice and immediate dissection of the suddenly died mice revealed expansive or rupturing AAA. The total AAA incidence rate is 83...
  19. Dissecting the Function and Regulation of Stress-Induced SUMOylation
    ROBERT CHARLES AUGUSTINE; Fiscal Year: 2013
    ..drives SIS, which are hypersensitive to many stresses and fail to elicit the SIS response;thereby permitting the dissection of SUMOylation during stress...
  20. FRET-based Biosensors to Monitor Redox in Cell Cycle Regulation
    Paul J A Kenis; Fiscal Year: 2012
    ..Aim 3: Create second generation FRET biosensors that permit visual monitoring and dissection of intraorganellar local redox potentials...
  21. Functional Genomic Dissection of Refractory Anemia
    BENJAMIN LEVINE EBERT; Fiscal Year: 2013
    ..In aggregate, these experiments will provide critical insight into the molecular basis of myelodysplastic syndrome. ..
  22. Biological &Environmental Mediators of Vitamin D and Aggressive Prostate Cancer
    ADAM BRYANT MURPHY; Fiscal Year: 2013
    ..proposed protocol would deepen his knowledge of immunohistochemistry, specimen processing, laser capture micro-dissection, tissue banking, genotyping and gene expression analysis...
  23. HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
    Hugh Rosen; Fiscal Year: 2010
    ..To date, the dissection of the contribution of Nox2-derived ROS to oxidants generated by other sources has been complicated by the lack ..
  24. Molecular-Genetic Dissection of Basal Forebrain Circuitry Regulating Arousal
    PATRICK MICHAEL FULLER; Fiscal Year: 2013
    ....
  25. Genetic Determinants of Drug Effects
    Tamara J Phillips; Fiscal Year: 2012
    ..We will advance our explorations through the use of genetic mouse models, gene expression methods, laser dissection technology, and RNA interference (RNAi) methods for selective gene silencing...
  26. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
    ..this proposed research is to better understand the physical weakening of the aortic wall that underlies arterial dissection;by understanding these mechanisms in this in vivo model, in vascular cells, and in spontaneously hypertensive ..
  27. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of ..
  28. Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    HUGO RAMON ROSEN; Fiscal Year: 2013
    ..In particular, careful dissection of these factors will be critical to the design of any effective T-cell based therapy...
  29. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..lesions may occur in both the thoracic and abdominal regions of the aortic tree and can deteriorate to vascular dissection and/or rupture that constitute a significant source of morbidity and mortality...
  30. Analysis of Hair Cell Regeneration in Zebrafish
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2010
    ..Combined, these two approaches will discover key hair cell regeneration genes and set the stage for a systematic dissection of this complex problem to inform the development of therapeutics to regenerate hair cells in mammals...
  31. Cisplatin Resistance mediated by copper export pathways
    Stephen B Howell; Fiscal Year: 2013
    ..A careful dissection of the mechanism by which ATP7B mediates the efflux of Pt drugs is expected to identify strategies for ..
  32. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010
    ..Most importantly, use of the Drosophila system facilitates genetic dissection of the host response, so that the host-pathogen interaction can be studied from both perspectives...
  33. Microfibril Fragments: Biomarkers of Aortic Disease
    Lynn Y Sakai; Fiscal Year: 2010
    Develop technologies for assessment of aortic aneurysms prone to rupture or dissection. Thoracic and abdominal aortic aneurysms (TAA and AAA) are life threatening conditions that comprise the thirteenth leading cause of death in the ..
  34. FASEB on Biology of Cilia and Flagella
    Bradley K Yoder; Fiscal Year: 2010
    ..that Chlamydomonas flagella are assembled by an Intraflagellar Transport (IFT) process and the subsequent dissection of the molecular underpinnings of IFT drove the discovery of genes encoding ciliary proteins responsible for ..
  35. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2013
    ..Because stress tolerance is intertwined with S. mutans virulence, the dissection of the mechanisms that allow these bacteria to thrive in oral biofilms during stressful conditions is central ..
  36. Spatiotemporal Regulation of Membrane Raft Trafficking in Virus Activated Cells
    Tione Buranda; Fiscal Year: 2012
    ..However, mechanistic dissection of virus entry has been hampered because glycoproteins of many hantaviruses are difficult to express and no ..
  37. Genetic Dissection of Auditory Circuit Assembly
    Lisa V Goodrich; Fiscal Year: 2013
    ..abstract_text> ..
  38. FANCD2 interaction with mismatch repair proteins and MCM2-7
    Gary M Kupfer; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Fanconi anemia (FA) is a genetic disease of cancer susceptibility whose dissection has led to the study of the DNA damage response and homologous recombinatorial repair...
  39. Molecular Dissection of Calmodulin Domain Functions
    Madeline A Shea; Fiscal Year: 2013
    ....
  40. Drosophila feeding behavior: New tools for the genetic dissection of prandiology
    William W Ja; Fiscal Year: 2012
    ..These discoveries are vital to the development of new therapeutics as well as preventative measures for obesity and other diseases. ..
  41. IMMUNE RESPONSES IN LUPUS
    Joseph Craft; Fiscal Year: 2013
    ..asking if the transcription factor Ascl2 is required for TFH cell differentiation and function, and if so, a dissection of the mechanism of its T cell-specific effects in immune responses...
  42. PHYSIOLOGICAL DISSECTION OF THE SCN
    Rae Silver; Fiscal Year: 2010
    ..The work also contributes to a better understanding of circadian changes associated with puberty, andropause, sleep regulation and some aspects of sex differences. ..
  43. Purine Salvage Pathway of Cryptosporidium Parvum
    Buddy Ullman; Fiscal Year: 2012
    ..cell biology, genetics, structural biology, and pharmacology, this proposal offers an interdisciplinary dissection of the purine salvage pathway of Cryptosporidium parvum, a protozoan parasite that is an opportunistic pathogen ..
  44. Molecular mechanisms of chemoresistance in breast cancer
    Manabu Kurokawa; Fiscal Year: 2013
    ..at Duke University Medical Center;our lab has considerable expertise in the biochemical analysis and molecular dissection of complex signaling pathways, both during apoptosis and cell cycle progression...
  45. Functional Dissection of Glucocorticoid Action in Metabolic Disease
    Charles A Harris; Fiscal Year: 2012
    ..In addition, the proposed research could point to the use of "dissociated GCs", safer anti-inflammatory medications to treat the millions of patients afflicted with inflammatory diseases. ..
  46. Cell Death Regulation by Pro-Apoptotic BOK During Hematopoiesis
    Samuel G Katz; Fiscal Year: 2013
    ..Thus, the proposed mechanistic dissection of BOK activity will advance our goal of developing novel pharmacologic approaches to regulate BOK for ..
  47. GENETIC DISSECTION OF PHOTOTRANSDUCTION
    Baruch Minke; Fiscal Year: 2011
    ..Therefore, studies on Drosophila TRP and TRPL channels are likely to be relevant for understanding retinal degeneration and mechanisms underlying the damage to RGC by glaucoma. ..
  48. GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place Cells
    TARA MONIQUE STEWART; Fiscal Year: 2012
    ..These studies will begin a molecular dissection of place field remapping, contribute to a deeper understanding of the role of HPC activity in age-related ..
  49. Live imaging of brain circuitry in mouse models of PTSD
    Elaine L Bearer; Fiscal Year: 2013
    ..1) Rodent models, with genetic alterations of SERT or after fear provocation with predator odor;2) Genetic dissection of human SERT, SLC6A4, and association of alleles with behavior;and 3) Magnetic resonance imaging (MRI), both ..
  50. Mechanisms of Degenerative Cell Death in C. elegans
    MONICA A DRISCOLL; Fiscal Year: 2013
    ..Our genetic dissection of this process in nematodes suggests that Ca+2 influx through the MEC DEG/ENaC channel is critical in necrosis ..
  51. Epi)Genomic drivers of primary and metastatic pancreatic islet cell carcinoma
    DOMINIC JAMES SMIRAGLIA; Fiscal Year: 2013
    ..This will increase the power of the pairwise comparisons between primary and metastatic tumors and will ultimately allow for dissection of multiple molecular routes of metastatic spread.
  52. ImmGen: gene expression and regulation in immune cells
    Christophe O Benoist; Fiscal Year: 2013
    ..who have performed in current grant period using a rigorous data generation and QC pipeline, a thorough dissection of gene expression and its regulation in >250 defined cell populations of the mouse immune system...
  53. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..We submit that this rigorous dissection of PBC will define pathways that will direct us to potential therapeutic venues...
  54. Endothelial NOS by protein to protein interactions
    William C Sessa; Fiscal Year: 2013
    ..in mind, we hypothesize that understanding the interactions between eNOS and Cav-1 will permit molecular dissection of the physiological (blood flow) and pathophysiological (atherogenesis) roles of Cav-1 as a negative regulator ..
  55. Molecular Mechanisms of Histone Acetyltransferases
    John M Denu; Fiscal Year: 2012
    ..However, unbiased dissection of the combinatorial PTM patterns recognized by chromatin binding proteins requires a platform for rapidly and ..
  56. Role of Reishi on cell surface proteins and signaling modulation in IBC
    IVETTE SUAREZ; Fiscal Year: 2013
    ..The proposed dissection of the molecular mechanisms of IBC is expected to significantly advance the current understanding and ..
  57. Genetic analysis fo metabolic syndrome by admixture mapping in African Americans
    Ludmila Pawlikowska; Fiscal Year: 2012
    ..b>Dissection of genetic influences on metabolic syndrome traits in a large ancestry-admixed cohort will illuminate the ..
  58. Dissecting mechanisms by which GI surgery delays diabetes onset in UCD-T2DM rats
    Peter J Havel; Fiscal Year: 2013
    ..New therapeutic targets will be pursued by performing microarray analysis of enteroendocrine cells isolated via laser capture dissection from selected gut segments and analyzing gut microbial populations by pyrosequencing.
  59. Genetics of the formation of repair &recombination foci
    RODNEY J ROTHSTEIN; Fiscal Year: 2013
    ..Our specific aims are as follows: (1) Continue our molecular and genetic dissection of checkpoint and repair foci using fluorescent protein tags to specifically label chromosomal double-strand ..
  60. Role of SIRT1 in melanocyte biology and melanocyte transformation
    Nihal Ahmad; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The genetic dissection of a complex process such as melanocytic transformation is a daunting task...
  61. Taste and feeding circuits in Drosophila
    MICHAEL DOUGLAS GORDON; Fiscal Year: 2010
    ..This will provide the anatomical framework for functional dissection of these cells. The second aim is to measure the activity of second-order neurons during taste detection...
  62. Genetic Analysis of Purine Metabolism in Leishmania donovani
    Buddy Ullman; Fiscal Year: 2013
    ..genetics, biochemistry, and cell biology, this competing continuation application offers an interdisciplinary dissection of the purine salvage pathway of Leishmania donovani, the etiologic agent of visceral leishmaniasis. L...
  63. Repressing HIF-1: targets and mechanisms
    Nianli Sang; Fiscal Year: 2012
    ..identification of HIF function as a master regulator of multiple angiogenic signaling pathways and the complete dissection of the conventional regulatory mechanisms of HIF function provide the possibility to target HIF as a better ..
  64. dnTGF Beta RII Mice and PBC
    William M Ridgway; Fiscal Year: 2013
    ..We submit that use of our unique murine constructs and our rigorous dissection of the mechanism of autoimmune cholangitis in this model will provide important clues towards successful ..
  65. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ..As a result of the success achieved in the dissection and translation of the distal Chr 1 QTL (Szs1) in the B6- D2 model, we have recently (February 2008) submitted a ..
  66. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA DONO
    Buddy Ullman; Fiscal Year: 2007
    ..structural biology, and computational chemistry this proposal offers a[unreadable] multidisciplinary dissection of the hypoxanthine-guanine[unreadable] phosphoribosyltransferase (HGPRT) enzyme from Leishmania donovani, an[..
  67. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
    ..Jr. The name of the principal investigator/programdirector must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OFCONTENTS Page Numbers Face Page 1 Description, ..
  68. Acupuncture for shoulder syndrome after ca surgery
    David Pfister; Fiscal Year: 2004
    BACKGROUND: Neck dissection is a common procedure for treatment of head and neck cancer...
  69. MOLECULAR DISSECTION OF CONGENITAL NEPHROGENIC DI
    ROBERT WILDIN; Fiscal Year: 2000
    ..The structure-function implications of the V2 ADHR mutation analysis will also contribute to a fuller understanding of STM receptors in general. ..
  70. GENETIC DISSECTION OF AGGRESSIVE BEHAVIOR OF HONEY BEES
    Greg Hunt; Fiscal Year: 2000
    ..3 cM with 95% confidence. It is proposed to use STS primers designed from the RAPD markers, SSCP polymorphisms and further development of another set of RAPD markers from 1000 10-mer primers, screened in bulk. ..
  71. Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney
    PETER MADRAS; Fiscal Year: 2007
    ..including conventional suture repair, tissue sealants, radiofrequency ablation, laser ablation, water dissection, and microwave tissue coagulation...
  72. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    ..stem cells; the fetal thymic organ culture, requires precise timed mating of murine breeders and then careful dissection of the resulting day 15 embryos. When successful, the technique produces very low numbers of human T cells...
  73. Endoscopic Detection of Fluorescein for Sentinel Lymph Node Biopsy
    James McGreevy; Fiscal Year: 2007
    ..This new device will allow the surgeon to perform the axillary dissection of lymph nodes in breast cancer patients with minimally-invasive surgical techniques...
  74. Chemical dissection of phospho-signaling that controls the caulobacter cell cycle
    JAMES CHRISTIANSEN ABELLERA BLAIR; Fiscal Year: 2010
    ..Since small molecule inhibitors will allow temporal dissection of the Caulobacter cell cycle, the experiments involve developing chemical inhibitors of signal transduction ..
  75. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
    The goal of this proposal is to elucidate the serotonin signaling pathways through genetic dissection of genes and functional pathways regulated by Selective Serotonin Reuptake Inhibitors (SSRIs)...
  76. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..