myocardial reperfusion

Summary

Summary: Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.

Top Publications

  1. ncbi Ischemic preconditioning may be transferable via whole blood transfusion: preliminary evidence
    E W Dickson
    University of Massachusetts Medical Center Department of Emergency Medicine, Worcester, Massachusetts 01655, USA
    J Thromb Thrombolysis 8:123-9. 1999
  2. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  3. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
  4. ncbi Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)
    Steven P Marso
    The Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
    Am J Cardiol 100:206-10. 2007
  5. doi High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction
    Walter Desmet
    Department of Cardiovascular Medicine, University Hospitals Leuven, Gasthuisberg, Herestraat 49, Leuven, Belgium
    Eur Heart J 32:867-77. 2011
  6. doi Randomized comparison of pre-hospital-initiated facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention in acute myocardial infarction very early after symptom onset: the LIPSIA-STEMI trial (Leipzig immediate preho
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:605-14. 2011
  7. ncbi Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017 2395, USA
    Am J Physiol Heart Circ Physiol 283:H1099-107. 2002
  8. doi The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    Matthias G Friedrich
    Stephenson Cardiovascular Magnetic Resonance Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Alberta, Canada
    J Am Coll Cardiol 51:1581-7. 2008
  9. doi Coronary response to diadenosine pentaphosphate after ischaemia-reperfusion in the isolated rat heart
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Cardiovasc Res 81:336-43. 2009
  10. ncbi Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Cardiovasc Res 77:782-90. 2008

Detail Information

Publications224 found, 100 shown here

  1. ncbi Ischemic preconditioning may be transferable via whole blood transfusion: preliminary evidence
    E W Dickson
    University of Massachusetts Medical Center Department of Emergency Medicine, Worcester, Massachusetts 01655, USA
    J Thromb Thrombolysis 8:123-9. 1999
    ..In conclusion, the ischemic preconditioning effect can be transferred to nonpreconditioned animals via whole blood transfusion, suggesting a humoral mechanism for preconditioning at a distance...
  2. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  3. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
    ..However, only if subsequent MPTP closure occurs will ATP levels be maintained, ensuring that cell death continues down an apoptotic, rather than a necrotic, pathway...
  4. ncbi Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)
    Steven P Marso
    The Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
    Am J Cardiol 100:206-10. 2007
    ..patients with ST-segment elevation myocardial infarction undergoing primary PCI, diabetes is independently associated with decreased myocardial reperfusion, larger infarct, development of congestive heart failure, and decreased survival.
  5. doi High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction
    Walter Desmet
    Department of Cardiovascular Medicine, University Hospitals Leuven, Gasthuisberg, Herestraat 49, Leuven, Belgium
    Eur Heart J 32:867-77. 2011
    Previous studies have suggested that intravenous administration of adenosine improves myocardial reperfusion and reduces infarct size in ST-elevation myocardial infarction (STEMI) patients...
  6. doi Randomized comparison of pre-hospital-initiated facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention in acute myocardial infarction very early after symptom onset: the LIPSIA-STEMI trial (Leipzig immediate preho
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:605-14. 2011
    ....
  7. ncbi Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017 2395, USA
    Am J Physiol Heart Circ Physiol 283:H1099-107. 2002
    ..06 +/- 0.01 ml x min(-1) x g(-1)). The development of macroscopic hemorrhage lagged behind no reflow, was closely correlated with it, and may be the consequence of microvascular damage...
  8. doi The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    Matthias G Friedrich
    Stephenson Cardiovascular Magnetic Resonance Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Alberta, Canada
    J Am Coll Cardiol 51:1581-7. 2008
    ..We aimed to characterize the tissue changes within the perfusion bed of infarct-related vessels in patients with acutely reperfused myocardial infarction (MI) using cardiovascular magnetic resonance (CMR)...
  9. doi Coronary response to diadenosine pentaphosphate after ischaemia-reperfusion in the isolated rat heart
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Cardiovasc Res 81:336-43. 2009
    ..The objective of this study was to analyse their effects in such conditions...
  10. ncbi Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Cardiovasc Res 77:782-90. 2008
    ..However, contradictory reports exist on the effects of acidic reperfusion on myocardial salvage. Here we characterized the effect of lowering the pH of the reperfusion media (pHo) on intracellular pH (pHi) and cell death...
  11. ncbi Prognostic differences between different types of bundle branch block during the early phase of acute myocardial infarction: insights from the Hirulog and Early Reperfusion or Occlusion (HERO)-2 trial
    Cheuk Kit Wong
    Cardiovascular Research Unit, Green Lane Cardiovascular Service, Auckland City Hospital, Private Bag 92024, Auckland 1030, New Zealand
    Eur Heart J 27:21-8. 2006
    ..Bundle branch block (BBB) early during acute myocardial infarction (AMI) is often considered high risk for mortality. Little is known about how different BBB types influence prognosis...
  12. ncbi Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction. Observations from the TIMI 14 trial
    J A de Lemos
    Cardiovascular Division, Brigham and Women s Hospital, Boston Massachusetts, USA
    Circulation 101:239-43. 2000
    ..We determined whether the combination of abciximab plus reduced-dose tPA provided additional benefit in terms of myocardial reperfusion, as evidenced by greater resolution of ST elevation.
  13. doi Primary angioplasty for any patient with ST-elevation myocardial infarction? Guideline-adherent feasibility and impact on mortality in a rural infarction network
    Ralf Birkemeyer
    Department of Cardiology, Schwarzwald Baar Klinikum, Villingen Schwenningen, Vöhrenbacherstrasse 23, 78050 Villingen Schwenningen, Germany
    Clin Res Cardiol 99:833-40. 2010
    ....
  14. doi Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: results of the erythropoietin in myocardial infarction trial
    Fabrice Prunier
    Université Angers, Laboratoire Protection et Remodelage du Myocarde, CHU Angers, Service de cardiologie, France
    Am Heart J 163:200-7.e1. 2012
    ..We investigated whether a single high-dose of EPO administered immediately after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) would limit infarct size...
  15. ncbi Evaluation of the time saved by prehospital initiation of reteplase for ST-elevation myocardial infarction: results of The Early Retavase-Thrombolysis in Myocardial Infarction (ER-TIMI) 19 trial
    David A Morrow
    Cardiovascular Division and TIMI Study Group, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 40:71-7. 2002
    ....
  16. doi Intra-aortic balloon counterpulsation and infarct size in patients with acute anterior myocardial infarction without shock: the CRISP AMI randomized trial
    Manesh R Patel
    Division of Cardiology, Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    JAMA 306:1329-37. 2011
    ..Intra-aortic balloon counterpulsation (IABC) is an adjunct to revascularization in patients with cardiogenic shock and reduces infarct size when placed prior to reperfusion in animal models...
  17. doi Prognostic value and determinants of a hypointense infarct core in T2-weighted cardiac magnetic resonance in acute reperfused ST-elevation-myocardial infarction
    Ingo Eitel
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circ Cardiovasc Imaging 4:354-62. 2011
    ..The aim of this study was to evaluate determinants and prognostic impact of a hypointense infarct core in T2-weighted CMR images, studied in patients after acute, reperfused ST-elevation-myocardial infarction...
  18. ncbi Morphologic validation of reperfused hemorrhagic myocardial infarction by cardiovascular magnetic resonance
    Cristina Basso
    Department of Medic Diagnostic Sciences and Special Therapies, University of Padua Medical School, Padua, Italy
    Am J Cardiol 100:1322-7. 2007
    ....
  19. ncbi Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury
    Joseph Pye
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27516, USA
    Am J Physiol Heart Circ Physiol 284:H919-26. 2003
    ..was inhibited by systemic administration of a 20S proteasome inhibitor (PS-519) in a porcine model of myocardial reperfusion injury...
  20. ncbi Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia
    Markus Rehm
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Circulation 116:1896-906. 2007
    ..As already demonstrated, this structure plays a key role in the regulation of inflammation and vascular permeability...
  21. ncbi Preconditioning the diabetic heart: the importance of Akt phosphorylation
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospitals, Grafton Way, London, WC1E 6DB, UK
    Diabetes 54:2360-4. 2005
    ..To protect the diabetic myocardium, it appears necessary to increase the IPC stimulus to achieve the threshold for cardioprotection and a critical level of Akt phosphorylation to mediate myocardial protection...
  22. ncbi Determinants and impact of microvascular obstruction in successfully reperfused ST-segment elevation myocardial infarction. Assessment by magnetic resonance imaging
    Jan Bogaert
    Department of Radiology, Gasthuisberg University Hospital, Herestraat 49, 3000, Leuven, Belgium
    Eur Radiol 17:2572-80. 2007
    ..Presence of MVO is associated with more extensive infarctions, and characterized by greater adverse LV remodeling and lack of functional recovery...
  23. doi Utilization and impact of pre-hospital electrocardiograms for patients with acute ST-segment elevation myocardial infarction: data from the NCDR (National Cardiovascular Data Registry) ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Re
    Deborah B Diercks
    Department of Emergency Medicine, University of California, Davis Medical Center, Sacramento, CA 95661, USA
    J Am Coll Cardiol 53:161-6. 2009
    ..This study sought to determine the association of pre-hospital electrocardiograms (ECGs) and the timing of reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI)...
  24. ncbi Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes
    Zequan Yang
    Department of Biomedical Engineering, University of Virginia Health System, Box 800759, Charlottesville, VA 22903, USA
    Circulation 114:2056-64. 2006
    ..In this study we show that CD4+ but not CD8+ T lymphocytes contribute to myocardial ischemia/reperfusion injury...
  25. ncbi 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in collaborat
    Elliott M Antman
    Circulation 117:296-329. 2008
  26. ncbi Rabbit heart can be "preconditioned" via transfer of coronary effluent
    E W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol 277:H2451-7. 1999
    ..Although adenosine and norepinephrine are apparently not responsible, these results suggest that remote protection is initiated by a humoral mechanism...
  27. doi Reperfused myocardial infarction: contrast-enhanced 64-Section CT in comparison to MR imaging
    Koen Nieman
    Cardiac MRI PET CT Program, Department of Radiology and the Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Boston, MA 02114, USA
    Radiology 247:49-56. 2008
    ..To prospectively compare 64-section multidetector computed tomography (CT) and cardiac magnetic resonance (MR) imaging for the early assessment of myocardial enhancement and infarct size after acute reperfused myocardial infarction (MI)...
  28. ncbi Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion
    Erik Lyseggen
    Institute for Surgical Research, Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 112:3901-10. 2005
    ....
  29. ncbi Angiographic and clinical outcomes in patients receiving low-molecular-weight heparin versus unfractionated heparin in ST-elevation myocardial infarction treated with fibrinolytics in the CLARITY-TIMI 28 Trial
    Marc S Sabatine
    Thrombolysis in Myocardial Infarction TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 112:3846-54. 2005
    ..Whether these advantages translate into greater infarct-related artery patency and fewer adverse clinical events in patients with ST-elevation myocardial infarction (STEMI) receiving fibrinolytic therapy remains under study...
  30. ncbi Mitochondrial K(ATP) channel opening is important during index ischemia and following myocardial reperfusion in ischemic preconditioned rat hearts
    R M Fryer
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 33:831-4. 2001
    ..8+/-6.9, respectively). These data suggest that activation of the mitochondrial K(ATP) channel is an important downstream regulator of myocardial protection with effects lasting into the reperfusion period following prolonged ischemia...
  31. ncbi Reperfusion arrhythmias: are they only a marker of epicardial reperfusion or continuing myocardial ischemia after acute myocardial infarction?
    Gulumser Heper
    Department of Cardiology, SSK Ihtisas Hospital, Etlik
    Angiology 58:663-70. 2007
    ..This finding suggests that the continuing myocardial ischemia represented by TIMI flow at the coronary angiography after acute myocardial infarction may have an important role in the pathogenesis of reperfusion arrhythmias...
  32. ncbi Reduction of "no-reflow" phenomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 6568, USA
    J Am Coll Cardiol 43:1291-8. 2004
    ..We hypothesized that IABC augmentation reduces the extent of microvascular obstruction after acute infarction...
  33. ncbi Sustained cardioprotection afforded by A2A adenosine receptor stimulation after 72 hours of myocardial reperfusion
    Matthieu Boucher
    Centre de biomédecine, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 45:439-46. 2005
    ..CREB activation and Hsp27 content do not seem to be associated with cardioprotection because they are enhanced in both treated groups, suggesting indirect A2A agonist and pathology-related effects...
  34. ncbi Primary percutaneous transluminal coronary angioplasty accelerates early myocardial reperfusion compared to thrombolytic therapy in patients with acute myocardial infarction
    Uwe Zeymer
    Medizinische Klinik II, Klinikum Kassel, Kassel, Germany
    Am Heart J 146:686-91. 2003
    ..The aim of this study was to compare early ST resolution in patients treated with primary percutaneous transluminal coronary angioplasty (PTCA) or thrombolytic therapy for AMI...
  35. ncbi Mechanical prevention of distal embolization during primary angioplasty: safety, feasibility, and impact on myocardial reperfusion
    Ugo Limbruno
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Circulation 108:171-6. 2003
    Effective myocardial reperfusion after primary percutaneous coronary intervention (PCI) may be limited by distal embolization...
  36. ncbi No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA
    Circulation 108:2911-7. 2003
    ..No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. But its fate on a long-term basis and potential significance for infarct healing are not yet known...
  37. ncbi Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion
    Erik Hedstrom
    Department of Clinical Physiology, Lund University, Lund, Sweden
    Scand Cardiovasc J 41:44-50. 2007
    ....
  38. ncbi Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction: the role of microthromboemboli
    Tadamichi Sakuma
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Am Soc Echocardiogr 16:15-21. 2003
    ..No reflow late after reperfusion is a result of tissue necrosis. The thrombus burden also affects ultimate IS...
  39. ncbi O2 delivery and redox state are determinants of compartment-specific reactive O2 species in myocardial reperfusion
    Jason D Stoner
    Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H109-16. 2007
    ..The redox state that develops during ischemia appears to be an important precursor for reperfusion ROS production...
  40. doi Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: association with oxidative stress and its impact on myocardial reperfusion
    Kei Yunoki
    Department of Cardiology, Osaka City General Hospital, Osaka, Japan
    Eur Heart J 33:1480-90. 2012
    ..The purpose of this study was to determine the associations of red blood cell (RBC) component of coronary thrombi with oxidative stress and myocardial reperfusion.
  41. ncbi Reperfused myocardial infarction as seen with use of necrosis-specific versus standard extracellular MR contrast media in rats
    M Saeed
    Department of Radiology, University of California San Francisco 94143 0628, USA
    Radiology 213:247-57. 1999
    ....
  42. doi Prevalence and significance of accelerated idioventricular rhythm in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
    Christian Juhl Terkelsen
    Department of Cardiology B, Aarhus University Hospital, Aarhus, Denmark
    Am J Cardiol 104:1641-6. 2009
    ..However, it is not a marker of successful reperfusion but is associated with extensive myocardial damage and delayed microvascular reperfusion...
  43. pmc Regional heterogeneity of myocardial reperfusion injury: effect of mild hypothermia
    Hirotsugu Hamamoto
    Harrison Department of Surgical Research, Glenolden Research Laboratory, University of Pennsylvania, Glenolden, Pennsylvania 19036, USA
    Ann Thorac Surg 87:164-71. 2009
    ..The effect of temperature on the extent and distribution of myocardial reperfusion injury in a collateral deficient ovine model was studied.
  44. ncbi Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts
    W R Ford
    Division of Cardiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Circulation 94:3087-9. 1996
    ..Whether short-term administration of AT1 or angiotensin II type 2 (AT2) receptor antagonists is cardioprotective has not been investigated...
  45. doi Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway
    Matthew J Lovell
    Centre for Clinical Pharmacology, Cardiovascular Biomedical Research Unit, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Atherosclerosis 213:67-76. 2010
    ..Our aim was therefore to try and quantify protection from myocardial injury by early infusion of BMMNCs in a rat ischaemia reperfusion (I/R) model...
  46. doi Ischemic postconditioning in pigs: no causal role for RISK activation
    Andreas Skyschally
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Circ Res 104:15-8. 2009
    ..In protocol 2, Wortmannin and U0126 blocked the increases in RISK phosphorylation during reperfusion, but infarct size was still smaller with IPoC (15+/-7%) than with IFR (35+/-6%; P<0.05)...
  47. doi Detection and quantification of myocardial reperfusion hemorrhage using T2*-weighted CMR
    Andreas Kumar
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    JACC Cardiovasc Imaging 4:1274-83. 2011
    ....
  48. ncbi Long-term inhibition of myocardial infarction by postconditioning during reperfusion
    James Mykytenko
    Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center Crawford Long Hospital Emory University School of Medicine, 550 Peachtree Street NE, Atlanta, GA 30308 2225, USA
    Basic Res Cardiol 102:90-100. 2007
    ..p < 0.05 24 vs. 3 h control; p < 0.05 postconditioning vs. time-matched control...
  49. pmc Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions
    Orhan Maden
    Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
    Can J Cardiol 25:e164-8. 2009
    ..However, their relationship with reperfusion abnormalities is less clear...
  50. doi Lethal myocardial reperfusion injury: a necessary evil?
    Borja Ibanez
    Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III C N I C, Madrid, Spain
    Int J Cardiol 151:3-11. 2011
    ..Currently, no intervention has been consistently shown to reduce reperfusion injury in large randomized multicenter trials, but the research in this field is intense and the future is highly promising...
  51. doi Impact of minimising door-to-balloon times in ST-elevation myocardial infarction to less than 30 min on outcome: an analysis over an 8-year period in a tertiary care centre
    Ulrike M Müller
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Centre, Strumpellstrasse 39, Leipzig, Germany
    Clin Res Cardiol 100:297-309. 2011
    ..We hypothesised that DBT of <30 min can be accomplished for the majority of patients...
  52. ncbi Time-dependent benefit of initial thrombosuction on myocardial reperfusion in primary percutaneous coronary intervention
    C L Chao
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Int J Clin Pract 62:555-61. 2008
    ..artery during primary percutaneous coronary intervention (PCI) may cause distal embolisation and impaired myocardial reperfusion. Clinical results of thromboembolic protection strategies have been controversial...
  53. ncbi Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospital, London, UK
    Circ Res 95:230-2. 2004
    ..In conclusion, we show for the first time that ischemic Postcond protects the myocardium by activating the prosurvival kinases PI3K-Akt, eNOS, and p70S6K in accordance with the RISK pathway...
  54. doi Differentiating ST elevation myocardial infarction and nonischemic causes of ST elevation by analyzing the presenting electrocardiogram
    Jason B Jayroe
    University of Texas Medical Branch, Galveston, TX, USA
    Am J Cardiol 103:301-6. 2009
    ..There is a need to revise our current electrocardiographic criteria for differentiating STEMI from NISTE...
  55. ncbi Right bundle-branch block in anterior acute myocardial infarction in the coronary intervention era: acute angiographic findings and prognosis
    Satoshi Kurisu
    Department of Cardiology, Hiroshima City Hospital, 7 33, Moto machi, Naka ku, Hiroshima, 730 8518 Japan
    Int J Cardiol 116:57-61. 2007
    ..Previous studies in the prethrombolytic or thrombolytic era have reported that right bundle-branch block (RBBB) is associated with poor clinical outcome in patients with acute myocardial infarction (AMI)...
  56. pmc Transfer for urgent percutaneous coronary intervention early after thrombolysis for ST-elevation myocardial infarction: the TRANSFER-AMI pilot feasibility study
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, Canada
    Can J Cardiol 22:1121-6. 2006
    ..Urgent PCI after thrombolysis may optimize reperfusion and prevent reinfarction and recurrent ischemia...
  57. ncbi Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
    ....
  58. doi System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention
    Christian Juhl Terkelsen
    Department of Cardiology, Aarhus University Hospital, DK 8200 Aarhus N, Denmark
    JAMA 304:763-71. 2010
    ..No previous studies have focused on the association between system delay and outcome in patients with STEMI treated with primary PCI...
  59. ncbi The no-reflow phenomenon: A basic mechanism of myocardial ischemia and reperfusion
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, Dept of Cardiology, Division of Cardiovascular Medicine at Keck School of Medicine, University of Southern California, 1225 Wilshire Boulevard, Los Angeles CA 90017, USA
    Basic Res Cardiol 101:359-72. 2006
    ....
  60. ncbi Signaling pathways in ischemic preconditioning
    James M Downey
    Department of Physiology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Heart Fail Rev 12:181-8. 2007
    ..The reperfused heart requires the support of the protective signals for only about an hour after which the ischemic injury is repaired and the signals are no longer needed...
  61. ncbi Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling
    A K Jonassen
    Department of Medical Physiology, Institute of Medical Biology, , Norway
    Circ Res 89:1191-8. 2001
    ..Moreover, BAD is maintained in its inert phosphorylated state in response to insulin therapy...
  62. doi Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy
    Tetsuji Miura
    Division of Cardiology, 2nd Dept of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Basic Res Cardiol 103:501-13. 2008
    ..Few agents have been thoroughly tested in clinically relevant animal models prior to their testing in man...
  63. pmc Optimal therapeutic strategies in the setting of post-infarct no reflow: the need for a pathogenetic classification
    L Galiuto
    Heart 90:123-5. 2004
  64. ncbi Myocardial perfusion as assessed by positron emission tomography during long-term mechanical circulatory support
    George V Letsou
    Department of Cardiothoracic and Vasculay, The University of Texas Houston Medical School, Houston, TX, USA
    Congest Heart Fail 12:69-74. 2006
    ..These pilot study findings suggest that the decreased metabolic requirements induced by ventricular unloading correspondingly decreased blood flow requirements to physiologically inactive myocardium...
  65. ncbi Development of systems of care for ST-elevation myocardial infarction patients: evaluation and outcomes
    Eric D Peterson
    Circulation 116:e64-7. 2007
  66. ncbi Acute treatment of myocardial infarction in Canada 1999-2002
    Cynthia A Jackevicius
    Pharmacy Department, University Health Network Toronto General Hospital, Toronto, Ontario M5G 2C4
    Can J Cardiol 21:145-52. 2005
    ..Therapy for management of acute myocardial infarction (AMI) varies according to patient, prescriber and geographical characteristics...
  67. doi Hypoxic conditioning suppresses nitric oxide production upon myocardial reperfusion
    Myoung Gwi Ryou
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Exp Biol Med (Maywood) 233:766-74. 2008
    ..Attenuation of the NOS/NO system may contribute to IHC-induced protection of myocardium from ischemia-reperfusion injury...
  68. ncbi Use of emergency medical services in acute myocardial infarction and subsequent quality of care: observations from the National Registry of Myocardial Infarction 2
    John G Canto
    Chest Pain Center and Division of Cardiovascular Diseases, University of Alabama at Birmingham, 35294 0012, USA
    Circulation 106:3018-23. 2002
    ..We examined use of the EMS in the United States and ascertained the factors that may influence its use by patients with acute MI...
  69. ncbi Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Cardiovasc Res 55:739-48. 2002
    ..This study investigates the effect of NCX inhibition with KB-R7943 at the time of reperfusion on cell viability...
  70. ncbi Prediction of clinical outcome after mechanical revascularization in acute myocardial infarction by markers of myocardial reperfusion
    Philipp K Haager
    Medical Clinic I, University Hospital RWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Am Coll Cardiol 41:532-8. 2003
    ..We sought to evaluate and compare recently suggested parameters of reperfusion after angioplasty in acute myocardial infarction (AMI) for risk stratification during long-term follow-up...
  71. ncbi Implementation of guidelines improves the standard of care: the Viennese registry on reperfusion strategies in ST-elevation myocardial infarction (Vienna STEMI registry)
    Karim Kalla
    Wilhelminenhospital, 3rd Medical Department, Medical University Vienna, Austria
    Circulation 113:2398-405. 2006
    ..The purpose of this study was to determine whether implementation of recent guidelines improves in-hospital mortality from acute ST-elevation myocardial infarction (STEMI) in a metropolitan area...
  72. ncbi Quantitative myocardial contrast echocardiography for prediction of thrombolysis in myocardial infarction flow in acute myocardial infarction
    Stuart Moir
    Department of Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4012, Australia
    Am J Cardiol 93:1212-7. 2004
    ..Thus, qualitative MCE identifies patients with STEMI but provides no information regarding infarct-related artery patency, whereas quantitative MCE can predict impaired flow in patients with acute STEMI...
  73. ncbi Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction: the DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) study
    Pedro Silva-Orrego
    Interventional Cardiology, A De Gasperis Department, Niguarda Hospital, Milan, Italy
    J Am Coll Cardiol 48:1552-9. 2006
    ..a new manual thrombus-aspirating device, before primary percutaneous coronary intervention (PPCI) may improve myocardial reperfusion compared with standard PPCI in patients with ST-segment elevation acute myocardial infarction (STEMI).
  74. ncbi Myocardial temperature reduction attenuates necrosis after prolonged ischemia in rabbits
    S L Hale
    Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017, USA
    Cardiovasc Res 40:502-7. 1998
    ..This study tests the hypothesis that a local reduction in cardiac temperature protects myocardium during prolonged ischemia (2 h) even if begun well after coronary artery occlusion...
  75. doi The paradigm of postconditioning to protect the heart
    C Penna
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Orbassano, Torino, Italy
    J Cell Mol Med 12:435-58. 2008
    ..Pharmacological PostC and possibly remote PostC may have a promising future in clinical scenario...
  76. pmc Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia
    Stig Muller
    Laboratory of Surgical Research, Institute of Clinical Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Crit Care 12:R20. 2008
    ..We hypothesised that restoring MAP by low dose, therapeutic level AVP would reduce vital organ blood flow in a setting of experimental acute left ventricular dysfunction...
  77. ncbi Three-dimensional microstructural abnormality of the coronary capillary network after myocardial reperfusion--comparison between 'reflow' and 'no-reflow'
    Nozomi Watanabe
    Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
    Circ J 68:868-72. 2004
    The 3-dimensional (D) structural abnormalities of the coronary capillary network and capillary volume changes after myocardial reperfusion were investigated using confocal laser scanning microscopy.
  78. ncbi Acute angiographic analysis of non-ST-segment elevation acute myocardial infarction
    Amr E Abbas
    Division of Cardiovascular Diseases, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Cardiol 94:907-9. 2004
    ..91, 95% confidence interval 1.62 to 5.22, p = 0.0003)...
  79. ncbi Normal flow (TIMI-3) before mechanical reperfusion therapy is an independent determinant of survival in acute myocardial infarction: analysis from the primary angioplasty in myocardial infarction trials
    G W Stone
    Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, NY, USA
    Circulation 104:636-41. 2001
    ..These data warrant prospective randomized trials of pharmacological strategies to promote early reperfusion before definitive mechanical intervention in acute myocardial infarction...
  80. ncbi Spontaneous anterograde flow of the infarct artery preserves myocardial perfusion and fatty acid metabolism in patients with anterior acute myocardial infarction
    Satoshi Kurisu
    Department of Cardiology, Hiroshima City Hospital, Hiroshima 730 8518, Japan
    Circ J 69:427-31. 2005
    ..It remains unclear whether spontaneous anterograde flow preserves myocardial fatty acid metabolism in patients with acute myocardial infarction (AMI)...
  81. pmc Angiographic assessment of prospectively determined non-invasive reperfusion indices in acute myocardial infarction
    A J Ophuis
    Department of Cardiology, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
    Heart 84:164-70. 2000
    ..To investigate the value of non-invasive reperfusion indices in acute myocardial infarction, avoiding the possible need for acute coronary angiography and subsequent angioplasty...
  82. ncbi A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study
    Paul W Armstrong
    Canadian VIGOUR Centre, 2 51 Medical Sciences Building, University of Alberta Edmonton, AB, Canada T6G 2H7
    Eur Heart J 27:1530-8. 2006
    ..We evaluated whether optimal pharmacologic therapy at the earliest point of care, emphasizing pre-hospital randomization and treatment was non-inferior to expeditious primary percutaneous coronary intervention (PCI)...
  83. ncbi Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging
    Andreas H Mahnken
    Diagnostic Radiology, University Hospital, Pauwelsstrasse 30 D 52074 Aachen, Germany
    J Am Coll Cardiol 45:2042-7. 2005
    ..The aim of this study was to examine if contrast-enhanced multislice spiral computed tomography (MSCT) is comparable to contrast-enhanced magnetic resonance imaging (MRI) for depiction of acute myocardial infarction (MI)...
  84. ncbi A feasibility study of contrast enhancement of acute myocardial infarction in multislice computed tomography: comparison with magnetic resonance imaging and gross morphology in pigs
    Arno Buecker
    Clinic of Diagnostic Radiology, University Hospital Aachen, Germany
    Invest Radiol 40:700-4. 2005
    ..The results were correlated with MRI and postmortem tissue staining...
  85. ncbi Hypothermia during reperfusion does not reduce myocardial infarct size in pigs
    Michael Maeng
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Basic Res Cardiol 101:61-8. 2006
    ..74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs...
  86. ncbi Manual thrombus-aspiration improves myocardial reperfusion: the randomized evaluation of the effect of mechanical reduction of distal embolization by thrombus-aspiration in primary and rescue angioplasty (REMEDIA) trial
    Francesco Burzotta
    Institute of Cardiology, Catholic University, Rome, Italy
    J Am Coll Cardiol 46:371-6. 2005
    ..The aim of this study was to evaluate the use of a new manual thrombus-aspirating device in unselected patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing urgent percutaneous coronary intervention (PCI)...
  87. ncbi Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomised trial
    E J Topol
    Desk F25, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA
    Lancet 357:1905-14. 2001
    ..We did a randomised, open-label trial to compare the effect of reteplase alone with reteplase plus abciximab in patients with acute myocardial infarction...
  88. ncbi Early noninvasive identification of failed reperfusion after intravenous thrombolytic therapy in acute myocardial infarction
    J T Stewart
    Department of Cardiology, Green Lane Hospital, Auckland, New Zealand
    J Am Coll Cardiol 31:1499-505. 1998
    ..This study sought to evaluate a biochemical approach to the early noninvasive assessment of reperfusion...
  89. ncbi Impact of spontaneous anterograde flow of the infarct artery on left ventricular function in patients with a first anterior wall acute myocardial infarction
    Masaharu Ishihara
    Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan
    Am J Cardiol 90:5-9. 2002
    ....
  90. ncbi Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion
    Trond Vartdal
    Department of Cardiology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Am Coll Cardiol 49:1715-21. 2007
    ....
  91. ncbi Detection of TIMI-3 flow before mechanical reperfusion with ultrasonic tissue characterization in patients with anterior wall acute myocardial infarction
    Katsuomi Iwakura
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
    Circulation 107:3159-64. 2003
    ..We investigated the ability of analyzing cardiac cycle-dependent variation of myocardial integrated backscatter (IBS) for predicting spontaneous reperfusion in anterior AMI...
  92. ncbi Assessment of myocardial viability in a reperfused porcine model: evaluation of different MSCT contrast protocols in acute and subacute infarct stages in comparison with MRI
    Harald Brodoefel
    Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    J Comput Assist Tomogr 31:290-8. 2007
    ..To assess myocardial viability in acute and subacute infarcts using different multislice spiral computed tomography contrast protocols with magnetic resonance imaging (MRI) correlation...
  93. ncbi Impact of time to treatment on myocardial reperfusion and infarct size with primary percutaneous coronary intervention for acute myocardial infarction (from the EMERALD Trial)
    Bruce R Brodie
    LeBauer Cardiovascular Research Foundation and Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
    Am J Cardiol 99:1680-6. 2007
    ..Incremental delays in reperfusion after 2 hours have less effect on infarct size. These data have implications regarding the triage of patients for primary PCI...
  94. ncbi Has my patient achieved adequate myocardial reperfusion?
    C Michael Gibson
    TIMI Study Group, Harvard Medical School, USA
    Circulation 108:504-7. 2003
  95. ncbi Meta-analysis of randomized trials comparing anti-embolic devices with standard PCI for improving myocardial reperfusion in patients with acute myocardial infarction
    Babu Kunadian
    Department of Cardiology, The James Cook University Hospital, Marton Road, Middlesbrough, United Kingdom
    Catheter Cardiovasc Interv 69:488-96. 2007
    Failure to achieve adequate myocardial reperfusion often occurs during PCI in patients with STEMI. This is in part due to atheromatous and thrombotic distal embolization...
  96. ncbi Epidemiology of acute myocardial infarction in the Italian CCU network: the BLITZ study
    Antonio Di Chiara
    S M Misericordia Hospital, Udine, Italy
    Eur Heart J 24:1616-29. 2003
    ....
  97. ncbi High dose adenosine for suboptimal myocardial reperfusion after primary PCI: A randomized placebo-controlled pilot study
    Martin G Stoel
    Department of Cardiology, Medisch Spectrum Twente, Enschede, The Netherlands
    Catheter Cardiovasc Interv 71:283-9. 2008
    ..This study was designed to investigate the influence of high dose intracoronary adenosine on persistent ST-segment elevation after primary percutaneous coronary intervention (PCI)...
  98. ncbi Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs
    Michael W Dae
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Am J Physiol Heart Circ Physiol 282:H1584-91. 2002
    ..Mild endovascular cooling to 34 degrees C lowers myocardial temperature sufficiently in human-sized hearts to cause a substantial cardioprotective effect, preserve microvascular flow, and maintain cardiac output...
  99. ncbi The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction, 2000-2002: findings from the National Registry of Myocardial Infarction-4
    Jeptha P Curtis
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8088, USA
    J Am Coll Cardiol 47:1544-52. 2006
    ....
  100. ncbi Early identification of impaired myocardial reperfusion with serial assessment of ST segments after percutaneous transluminal coronary angioplasty during acute myocardial infarction
    J Watanabe
    The Cardiovascular Center, Kansai Medical University, Osaka, Japan
    Am J Cardiol 88:956-9. 2001
    ..Thus, persistent ST-segment elevation 30 minutes after primary PTCA was a highly specific electrocardiographic marker of impaired reperfusion in patients with AMI...
  101. ncbi Quantitative evaluation of myocardial perfusion in patients with revascularized myocardial infarction: comparison between intravenous myocardial contrast echocardiography and 99mTc-sestamibi single photon emission computed tomography
    Gertjan Tj Sieswerda
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Echocardiogr 5:41-50. 2004
    ..This two-center study compared quantitative segmental perfusion mapping by intravenous myocardial contrast echocardiography (ivMCE) and scintigraphy (SPECT) in patients in the subacute phase of myocardial infarction (AMI)...

Research Grants72

  1. Peroxynitrite in Cardiac Ischemia/Reperfusion
    Xin Liang Ma; Fiscal Year: 2010
    ..for myocardial apoptosis after MI/R, and to search for the optimal therapeutic strategies that will reduce myocardial reperfusion injury...
  2. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury...
  3. Cytoprotective cytokine signaling and reperfusion injury
    Douglas Mann; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Myocardial reperfusion following a period of ischemia may be regarded as a "mixed blessing...
  4. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Myocardial reperfusion following a period of ischemia may be regarded as a "mixed blessing...
  5. Mechanism of Myocardial Reperfusion Injury in Diabetes
    David Lefer; Fiscal Year: 2007
    ..effects of NO therapy on home oxygenase-1 (HO-1) activation and myocardial protection in the setting of myocardial reperfusion injury in the diabetic heart...
  6. Mechanism of Myocardial Reperfusion Injury in Diabetes
    David Lefer; Fiscal Year: 2006
    ..effects of NO therapy on home oxygenase-1 (HO-1) activation and myocardial protection in the setting of myocardial reperfusion injury in the diabetic heart...
  7. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2007
    ..We propose that myocardial reperfusion injury to the endothelium will be modest in TNF-alpha knockout (TNF-/-) mice, severe in TNF-alpha over-..
  8. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2009
    ..We propose that myocardial reperfusion injury to the endothelium will be modest in TNF-alpha knockout (TNF-/-) mice, severe in TNF-alpha over-..
  9. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2010
    ..We propose that myocardial reperfusion injury to the endothelium will be modest in TNF-alpha knockout (TNF-/-) mice, severe in TNF-alpha over-..
  10. AGING, LIPID PEROXIDATION, AND CARDIAC REPERFUSION
    Luke Szweda; Fiscal Year: 2003
    ..specific mitochondrial proteins(s) by HNE and that these processes contribute to age-related increases in myocardial reperfusion injury...
  11. Peroxynitrite in Cardiac Ischemia/Reperfusion Injury
    Xin Liang Ma; Fiscal Year: 2003
    ..tissue damage comparable to that caused by OH Although these in vitra studies support a role for ONOO- in myocardial reperfusion injury, extension of these observations to relevant whole organs or to in viva models is lacking...
  12. Cytochrome P450 in Reperfusion Injury
    Roberta Gottlieb; Fiscal Year: 2007
    ..This proposal identifies cytochrome P450 monooxygenases as a previously underestimated factor in myocardial reperfusion injury, and establishes the basis for a novel therapeutic approach
  13. PHOSPHOLIPID DEGRADATION IN REPERFUSION INJURY
    DIPAK DAS; Fiscal Year: 1993
    Degradation of membrane phospholipids play a crucial role in the pathophysiology of myocardial reperfusion injury...
  14. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..inhibition of PARS on endothelial injury and neutrophil accumulation will be studied in a rat model of myocardial reperfusion injury...
  15. PHOSPHOLIPIDS IN MYOCARDIAL REPERFUSION INJURY
    DIPAK DAS; Fiscal Year: 2000
    ..The ultimate goal of this investigation is to develop modalities to block apoptosis during reperfusion of the ischemic heart, which will hopefully ameliorate reperfusion injury. ..
  16. Mechanisms of photobiomodulation in myocardial reperfusion injury
    Phillip F Pratt; Fiscal Year: 2010
    ..Near infrared light, alone or in combination with other pharmacological adjuvants could offer a unique strategy to mitigate the damage that occurs to the ischemic myocardium during reperfusion of the coronary artery. ..
  17. Endothelial Dysfunction in Postischemic Hearts
    Yong Xia; Fiscal Year: 2007
    ..This unbalanced NO decrease/superoxide increase are the key initiating events in the pathogenesis of myocardial reperfusion injury...
  18. Endothelial Dysfunction in Postischemic Hearts
    Yong Xia; Fiscal Year: 2010
    ..This unbalanced NO decrease/superoxide increase are the key initiating events in the pathogenesis of myocardial reperfusion injury...
  19. Endothelial Dysfunction in Postischemic Hearts
    Yong Xia; Fiscal Year: 2009
    ..This unbalanced NO decrease/superoxide increase are the key initiating events in the pathogenesis of myocardial reperfusion injury...
  20. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2005
    ..our studies on the role of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in the pathogenesis of myocardial reperfusion injury...
  21. Modified Late Infarct Reperfusion to Prevent Post MI CHF
    Robert Gorman; Fiscal Year: 2006
    ..It is not the central focus of this proposal to explore the mechanism of myocardial reperfusion injury (although the apoptosis studies will provide new information on how this unique form of cell death ..
  22. Peroxynitrite in Cardiac Ischemia/Reperfusion
    Xin Liang Ma; Fiscal Year: 2009
    ..for myocardial apoptosis after MI/R, and to search for the optimal therapeutic strategies that will reduce myocardial reperfusion injury...