myocardial reperfusion

Summary

Summary: Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.

Top Publications

  1. ncbi Ischemic preconditioning may be transferable via whole blood transfusion: preliminary evidence
    E W Dickson
    University of Massachusetts Medical Center Department of Emergency Medicine, Worcester, Massachusetts 01655, USA
    J Thromb Thrombolysis 8:123-9. 1999
  2. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  3. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
  4. ncbi Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospital, London, UK
    Circ Res 95:230-2. 2004
  5. ncbi Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway
    Matthew J Lovell
    Centre for Clinical Pharmacology, Cardiovascular Biomedical Research Unit, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Atherosclerosis 213:67-76. 2010
  6. ncbi Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)
    Steven P Marso
    The Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
    Am J Cardiol 100:206-10. 2007
  7. ncbi Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
    Hajime Kin
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
    Cardiovasc Res 62:74-85. 2004
  8. ncbi Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017 2395, USA
    Am J Physiol Heart Circ Physiol 283:H1099-107. 2002
  9. ncbi Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
    Chad E Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 289:H1618-26. 2005
  10. ncbi The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis
    Michael V Cohen
    Department of Physiology, MSB 3050, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Circulation 115:1895-903. 2007

Detail Information

Publications245 found, 100 shown here

  1. ncbi Ischemic preconditioning may be transferable via whole blood transfusion: preliminary evidence
    E W Dickson
    University of Massachusetts Medical Center Department of Emergency Medicine, Worcester, Massachusetts 01655, USA
    J Thromb Thrombolysis 8:123-9. 1999
    ..In conclusion, the ischemic preconditioning effect can be transferred to nonpreconditioned animals via whole blood transfusion, suggesting a humoral mechanism for preconditioning at a distance...
  2. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  3. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
    ..However, only if subsequent MPTP closure occurs will ATP levels be maintained, ensuring that cell death continues down an apoptotic, rather than a necrotic, pathway...
  4. ncbi Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospital, London, UK
    Circ Res 95:230-2. 2004
    ..In conclusion, we show for the first time that ischemic Postcond protects the myocardium by activating the prosurvival kinases PI3K-Akt, eNOS, and p70S6K in accordance with the RISK pathway...
  5. ncbi Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway
    Matthew J Lovell
    Centre for Clinical Pharmacology, Cardiovascular Biomedical Research Unit, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Atherosclerosis 213:67-76. 2010
    ..Our aim was therefore to try and quantify protection from myocardial injury by early infusion of BMMNCs in a rat ischaemia reperfusion (I/R) model...
  6. ncbi Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)
    Steven P Marso
    The Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
    Am J Cardiol 100:206-10. 2007
    ..patients with ST-segment elevation myocardial infarction undergoing primary PCI, diabetes is independently associated with decreased myocardial reperfusion, larger infarct, development of congestive heart failure, and decreased survival.
  7. ncbi Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
    Hajime Kin
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
    Cardiovasc Res 62:74-85. 2004
    ..This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection...
  8. ncbi Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017 2395, USA
    Am J Physiol Heart Circ Physiol 283:H1099-107. 2002
    ..06 +/- 0.01 ml x min(-1) x g(-1)). The development of macroscopic hemorrhage lagged behind no reflow, was closely correlated with it, and may be the consequence of microvascular damage...
  9. ncbi Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
    Chad E Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 289:H1618-26. 2005
    ..Thus our results implicate the involvement of ERK1/2 rather than PI3-kinase/Akt in the reduction of infarct size achieved with post-C...
  10. ncbi The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis
    Michael V Cohen
    Department of Physiology, MSB 3050, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Circulation 115:1895-903. 2007
    ..Acidosis also suppresses MPTP formation. We tested whether postconditioning protects by maintaining acidosis during early reoxygenation...
  11. ncbi Reperfused myocardial infarction as seen with use of necrosis-specific versus standard extracellular MR contrast media in rats
    M Saeed
    Department of Radiology, University of California San Francisco 94143 0628, USA
    Radiology 213:247-57. 1999
    ....
  12. pmc Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization
    Yasuo M Tsutsumi
    Department of Anesthesiology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California 92161, USA
    Life Sci 81:1223-7. 2007
    ..These data indicate that ROS signaling is an essential trigger of ischemic and pharmacological PostC and this is occurring at the level of the cardiac myocyte...
  13. ncbi Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway
    Min Zhu
    Institute of Anesthesiology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    Cardiovasc Res 72:152-62. 2006
    ..We tested whether ischemic postconditioning (IPostC) is protective in remodeled myocardium...
  14. ncbi Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction: the role of microthromboemboli
    Tadamichi Sakuma
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Am Soc Echocardiogr 16:15-21. 2003
    ..No reflow late after reperfusion is a result of tissue necrosis. The thrombus burden also affects ultimate IS...
  15. ncbi Utilization and impact of pre-hospital electrocardiograms for patients with acute ST-segment elevation myocardial infarction: data from the NCDR (National Cardiovascular Data Registry) ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Re
    Deborah B Diercks
    Department of Emergency Medicine, University of California, Davis Medical Center, Sacramento, CA 95661, USA
    J Am Coll Cardiol 53:161-6. 2009
    ..This study sought to determine the association of pre-hospital electrocardiograms (ECGs) and the timing of reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI)...
  16. ncbi Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes
    Zequan Yang
    Department of Biomedical Engineering, University of Virginia Health System, Box 800759, Charlottesville, VA 22903, USA
    Circulation 114:2056-64. 2006
    ..In this study we show that CD4+ but not CD8+ T lymphocytes contribute to myocardial ischemia/reperfusion injury...
  17. ncbi Postconditioning in rats and mice
    Mari Liis Kaljusto
    Department of Cardiothoracic Surgery, Ulleval University Hospital, Oslo, Norway
    Scand Cardiovasc J 40:334-41. 2006
    ..For subsequent studies on the molecular mechanisms of postconditioning, we aimed to identify a robust postconditioning protocol in rat and mouse heart...
  18. ncbi The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    Matthias G Friedrich
    Stephenson Cardiovascular Magnetic Resonance Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Alberta, Canada
    J Am Coll Cardiol 51:1581-7. 2008
    ..We aimed to characterize the tissue changes within the perfusion bed of infarct-related vessels in patients with acutely reperfused myocardial infarction (MI) using cardiovascular magnetic resonance (CMR)...
  19. ncbi Calcium-mediated cell death during myocardial reperfusion
    David Garcia-Dorado
    Universitat Autonoma de Barcelona, Barcelona, Spain
    Cardiovasc Res 94:168-80. 2012
    ....
  20. ncbi Determinants and impact of microvascular obstruction in successfully reperfused ST-segment elevation myocardial infarction. Assessment by magnetic resonance imaging
    Jan Bogaert
    Department of Radiology, Gasthuisberg University Hospital, Herestraat 49, 3000, Leuven, Belgium
    Eur Radiol 17:2572-80. 2007
    ..Presence of MVO is associated with more extensive infarctions, and characterized by greater adverse LV remodeling and lack of functional recovery...
  21. ncbi Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning
    Masashi Fujita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Physiol Heart Circ Physiol 292:H2004-8. 2007
    ..In conclusion, postconditioning mediates its cardioprotective effects possibly via prolonged transient acidosis during the early reperfusion phase with the activation of Akt and ERK...
  22. ncbi Postconditioning: reduction of reperfusion-induced injury
    Zhi qing Zhao
    Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory Crawford Long Hospital, Emory University, 550 Peachtree Street NE, Atlanta, Georgia 30308 2225, USA
    Cardiovasc Res 70:200-11. 2006
    ..Postconditioning indirectly supports the concept of reperfusion injury in animal models of ischaemia-reperfusion and in patients, and exerts cardioprotection that is equivalent to that of ischaemic preconditioning...
  23. ncbi Assessment of severe reperfusion injury with T2* cardiac MRI in patients with acute myocardial infarction
    Declan P O'Regan
    MRC Clinical Sciences Centre, Robert Steiner MRI Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, UK
    Heart 96:1885-91. 2010
    ..Non-invasive assessment of interstitial myocardial haemorrhage by T2* cardiac MRI (T2*-CMR) provides a novel and specific biomarker of severe reperfusion injury which may be of prognostic value...
  24. ncbi Randomized comparison of pre-hospital-initiated facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention in acute myocardial infarction very early after symptom onset: the LIPSIA-STEMI trial (Leipzig immediate preho
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:605-14. 2011
    ....
  25. ncbi Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts
    W R Ford
    Division of Cardiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Circulation 94:3087-9. 1996
    ..Whether short-term administration of AT1 or angiotensin II type 2 (AT2) receptor antagonists is cardioprotective has not been investigated...
  26. ncbi Detection and quantification of myocardial reperfusion hemorrhage using T2*-weighted CMR
    Andreas Kumar
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    JACC Cardiovasc Imaging 4:1274-83. 2011
    ....
  27. ncbi Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Cardiovasc Res 77:782-90. 2008
    ..However, contradictory reports exist on the effects of acidic reperfusion on myocardial salvage. Here we characterized the effect of lowering the pH of the reperfusion media (pHo) on intracellular pH (pHi) and cell death...
  28. ncbi Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: results of the erythropoietin in myocardial infarction trial
    Fabrice Prunier
    Université Angers, Laboratoire Protection et Remodelage du Myocarde, CHU Angers, Service de cardiologie, France
    Am Heart J 163:200-7.e1. 2012
    ..We investigated whether a single high-dose of EPO administered immediately after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) would limit infarct size...
  29. ncbi Evaluation of the time saved by prehospital initiation of reteplase for ST-elevation myocardial infarction: results of The Early Retavase-Thrombolysis in Myocardial Infarction (ER-TIMI) 19 trial
    David A Morrow
    Cardiovascular Division and TIMI Study Group, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 40:71-7. 2002
    ....
  30. ncbi Prognostic differences between different types of bundle branch block during the early phase of acute myocardial infarction: insights from the Hirulog and Early Reperfusion or Occlusion (HERO)-2 trial
    Cheuk Kit Wong
    Cardiovascular Research Unit, Green Lane Cardiovascular Service, Auckland City Hospital, Private Bag 92024, Auckland 1030, New Zealand
    Eur Heart J 27:21-8. 2006
    ..Bundle branch block (BBB) early during acute myocardial infarction (AMI) is often considered high risk for mortality. Little is known about how different BBB types influence prognosis...
  31. ncbi Intra-aortic balloon counterpulsation and infarct size in patients with acute anterior myocardial infarction without shock: the CRISP AMI randomized trial
    Manesh R Patel
    Division of Cardiology, Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    JAMA 306:1329-37. 2011
    ..Intra-aortic balloon counterpulsation (IABC) is an adjunct to revascularization in patients with cardiogenic shock and reduces infarct size when placed prior to reperfusion in animal models...
  32. ncbi Coronary response to diadenosine pentaphosphate after ischaemia-reperfusion in the isolated rat heart
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Cardiovasc Res 81:336-43. 2009
    ..The objective of this study was to analyse their effects in such conditions...
  33. ncbi Primary angioplasty for any patient with ST-elevation myocardial infarction? Guideline-adherent feasibility and impact on mortality in a rural infarction network
    Ralf Birkemeyer
    Department of Cardiology, Schwarzwald Baar Klinikum, Villingen Schwenningen, Vöhrenbacherstrasse 23, 78050 Villingen Schwenningen, Germany
    Clin Res Cardiol 99:833-40. 2010
    ....
  34. ncbi Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction. Observations from the TIMI 14 trial
    J A de Lemos
    Cardiovascular Division, Brigham and Women s Hospital, Boston Massachusetts, USA
    Circulation 101:239-43. 2000
    ..We determined whether the combination of abciximab plus reduced-dose tPA provided additional benefit in terms of myocardial reperfusion, as evidenced by greater resolution of ST elevation.
  35. ncbi Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury
    Joseph Pye
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27516, USA
    Am J Physiol Heart Circ Physiol 284:H919-26. 2003
    ..was inhibited by systemic administration of a 20S proteasome inhibitor (PS-519) in a porcine model of myocardial reperfusion injury...
  36. ncbi Morphologic validation of reperfused hemorrhagic myocardial infarction by cardiovascular magnetic resonance
    Cristina Basso
    Department of Medic Diagnostic Sciences and Special Therapies, University of Padua Medical School, Padua, Italy
    Am J Cardiol 100:1322-7. 2007
    ....
  37. ncbi Preconditioning the diabetic heart: the importance of Akt phosphorylation
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospitals, Grafton Way, London, WC1E 6DB, UK
    Diabetes 54:2360-4. 2005
    ..To protect the diabetic myocardium, it appears necessary to increase the IPC stimulus to achieve the threshold for cardioprotection and a critical level of Akt phosphorylation to mediate myocardial protection...
  38. ncbi Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia
    Markus Rehm
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Circulation 116:1896-906. 2007
    ..As already demonstrated, this structure plays a key role in the regulation of inflammation and vascular permeability...
  39. ncbi Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
    ....
  40. ncbi B-type natriuretic peptide at early reperfusion limits infarct size in the rat isolated heart
    Dwaine S Burley
    The Royal Veterinary College, University of London, London, UK
    Basic Res Cardiol 102:529-41. 2007
    ..Furthermore, endogenous activation of pGC could play a role in the mechanism of postconditioning...
  41. ncbi 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in collaborat
    Elliott M Antman
    Circulation 117:296-329. 2008
  42. ncbi Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers
    Stefanie Gilles
    Department of Physiology, University of Munich, Schillerstr 44, 80336 Munich, Germany
    Cardiovasc Res 60:608-16. 2003
    ..Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-alpha (TNF-alpha) and for activating TNF-alpha-converting enzyme (TACE)...
  43. ncbi Brief repetitive balloon occlusions enhance reperfusion during percutaneous coronary intervention for acute myocardial infarction: a pilot study
    Warren K Laskey
    Division of Cardiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Catheter Cardiovasc Interv 65:361-7. 2005
    ..Such ischemic conditioning represents a potentially useful adjunct to strategies for enhancing reperfusion during acute myocardial infarction...
  44. ncbi PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning
    Jean Chrisostome Bopassa
    INSERM E0226, Universite Claude Bernard Lyon I, Laboratoire de Physiologie Lyon Nord 8, avenue Rockefeller, 69373 Lyon Cedex 08, France
    Cardiovasc Res 69:178-85. 2006
    ..We investigated whether phosphatidylinositol 3-kinase (PI3K) might regulate mitochondrial permeability transition pore (mPTP) opening in hearts reperfused with either low pressure or postconditioning...
  45. ncbi Implementation of guidelines improves the standard of care: the Viennese registry on reperfusion strategies in ST-elevation myocardial infarction (Vienna STEMI registry)
    Karim Kalla
    Wilhelminenhospital, 3rd Medical Department, Medical University Vienna, Austria
    Circulation 113:2398-405. 2006
    ..The purpose of this study was to determine whether implementation of recent guidelines improves in-hospital mortality from acute ST-elevation myocardial infarction (STEMI) in a metropolitan area...
  46. ncbi Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
    ....
  47. ncbi Prognostic value and determinants of a hypointense infarct core in T2-weighted cardiac magnetic resonance in acute reperfused ST-elevation-myocardial infarction
    Ingo Eitel
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circ Cardiovasc Imaging 4:354-62. 2011
    ..The aim of this study was to evaluate determinants and prognostic impact of a hypointense infarct core in T2-weighted CMR images, studied in patients after acute, reperfused ST-elevation-myocardial infarction...
  48. ncbi High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction
    Walter Desmet
    Department of Cardiovascular Medicine, University Hospitals Leuven, Gasthuisberg, Herestraat 49, Leuven, Belgium
    Eur Heart J 32:867-77. 2011
    Previous studies have suggested that intravenous administration of adenosine improves myocardial reperfusion and reduces infarct size in ST-elevation myocardial infarction (STEMI) patients...
  49. ncbi Rabbit heart can be "preconditioned" via transfer of coronary effluent
    E W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol 277:H2451-7. 1999
    ..Although adenosine and norepinephrine are apparently not responsible, these results suggest that remote protection is initiated by a humoral mechanism...
  50. ncbi Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion
    Erik Lyseggen
    Institute for Surgical Research, Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 112:3901-10. 2005
    ....
  51. ncbi Angiographic and clinical outcomes in patients receiving low-molecular-weight heparin versus unfractionated heparin in ST-elevation myocardial infarction treated with fibrinolytics in the CLARITY-TIMI 28 Trial
    Marc S Sabatine
    Thrombolysis in Myocardial Infarction TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 112:3846-54. 2005
    ..Whether these advantages translate into greater infarct-related artery patency and fewer adverse clinical events in patients with ST-elevation myocardial infarction (STEMI) receiving fibrinolytic therapy remains under study...
  52. ncbi Mitochondrial K(ATP) channel opening is important during index ischemia and following myocardial reperfusion in ischemic preconditioned rat hearts
    R M Fryer
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 33:831-4. 2001
    ..8+/-6.9, respectively). These data suggest that activation of the mitochondrial K(ATP) channel is an important downstream regulator of myocardial protection with effects lasting into the reperfusion period following prolonged ischemia...
  53. ncbi Reperfused myocardial infarction: contrast-enhanced 64-Section CT in comparison to MR imaging
    Koen Nieman
    Cardiac MRI PET CT Program, Department of Radiology and the Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Boston, MA 02114, USA
    Radiology 247:49-56. 2008
    ..To prospectively compare 64-section multidetector computed tomography (CT) and cardiac magnetic resonance (MR) imaging for the early assessment of myocardial enhancement and infarct size after acute reperfused myocardial infarction (MI)...
  54. ncbi Microvasculature in acute myocardial ischemia: part II: evolving concepts in pathophysiology, diagnosis, and treatment
    Sanjiv Kaul
    Cardiovascular Division, Box 800158, Medical Center, University of Virginia, Charlottesville, VA 22908 0158, USA
    Circulation 109:310-5. 2004
  55. ncbi Clinical outcome and left ventricular remodeling in AMI patients with insufficient myocardial reperfusion after recanalization
    Jun Jin
    Xinqiao Hospital, Chongqing City, PR China
    Clin Invest Med 33:E304-12. 2010
    ..In this study, we investigated whether insufficient myocardial reperfusion plays an important role in left ventricular (LV) remodeling and functional recovery in patients with ..
  56. ncbi High QRS score on admission strongly predicts impaired myocardial reperfusion in patients with a first anterior acute myocardial infarction
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, 4 57 Urafune cho, Minamiku, Yokohama 232 0024, Japan
    Circ J 75:626-32. 2011
    ..infarction (AMI), QRS score at presentation electrocardiogram (ECG) may reflect the evolutionary stage of the infarction and allow one to predict the degree of myocardial reperfusion potentially achievable by reperfusion therapy.
  57. ncbi Ischemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm
    Michael Galagudza
    Department of Pathophysiology and Laboratory of Circulation, St Petersburg I P Pavlov Federal Medical University, Russian Federation
    Eur J Cardiothorac Surg 25:1006-10. 2004
    ..This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of postconditioning on persistent reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart model...
  58. ncbi Hypothermia during reperfusion does not reduce myocardial infarct size in pigs
    Michael Maeng
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Basic Res Cardiol 101:61-8. 2006
    ..74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs...
  59. ncbi Acute angiographic analysis of non-ST-segment elevation acute myocardial infarction
    Amr E Abbas
    Division of Cardiovascular Diseases, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Cardiol 94:907-9. 2004
    ..91, 95% confidence interval 1.62 to 5.22, p = 0.0003)...
  60. ncbi The no-reflow phenomenon: A basic mechanism of myocardial ischemia and reperfusion
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, Dept of Cardiology, Division of Cardiovascular Medicine at Keck School of Medicine, University of Southern California, 1225 Wilshire Boulevard, Los Angeles CA 90017, USA
    Basic Res Cardiol 101:359-72. 2006
    ....
  61. ncbi No prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery
    Kirsten A Kortekaas
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cardiothorac Surg 41:e117-25. 2012
    ..Although complement inhibitors are highly effective in animals, clinical trials fail to show a substantial benefit in humans. This raises questions on the role of complement activation in human myocardial I/R injury...
  62. ncbi Markers of myocardial reperfusion as predictors of left ventricular function recovery in acute myocardial infarction treated with primary angioplasty
    Francesco Bellandi
    Division of Cardiology, Misericordia e Dolce Hospital, Prato, Italy
    Clin Cardiol 27:683-8. 2004
    Myocardial blush grade (MBG), corrected TIMI frame count (cTFC), and ST-segment reduction are indices of myocardial reperfusion.
  63. ncbi Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning
    Takamichi Uchiyama
    Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1110, USA
    Circulation 109:3042-9. 2004
    ..In this study, we investigated whether Akt signaling has a role in the antiapoptotic pathways of preconditioning against hypoxia/reoxygenation (H/R)...
  64. ncbi Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion
    Christian Kupatt
    Internal Medicine I, Klinikum Grosshadern, Munich, Germany
    J Leukoc Biol 72:455-61. 2002
    ..23+/-4/field), an effect sensitive to Tirofiban inhibition (23+/-4 leukocytes/field, 22+/-3 platelets/field). We conclude that platelets contribute postischemic leukocyte adhesion in the heart via P-selectin and GPIIb/IIIa...
  65. ncbi O2 delivery and redox state are determinants of compartment-specific reactive O2 species in myocardial reperfusion
    Jason D Stoner
    Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H109-16. 2007
    ..The redox state that develops during ischemia appears to be an important precursor for reperfusion ROS production...
  66. ncbi No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA
    Circulation 108:2911-7. 2003
    ..No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. But its fate on a long-term basis and potential significance for infarct healing are not yet known...
  67. pmc Regional heterogeneity of myocardial reperfusion injury: effect of mild hypothermia
    Hirotsugu Hamamoto
    Harrison Department of Surgical Research, Glenolden Research Laboratory, University of Pennsylvania, Glenolden, Pennsylvania 19036, USA
    Ann Thorac Surg 87:164-71. 2009
    ..The effect of temperature on the extent and distribution of myocardial reperfusion injury in a collateral deficient ovine model was studied.
  68. ncbi Prevalence and significance of accelerated idioventricular rhythm in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
    Christian Juhl Terkelsen
    Department of Cardiology B, Aarhus University Hospital, Aarhus, Denmark
    Am J Cardiol 104:1641-6. 2009
    ..However, it is not a marker of successful reperfusion but is associated with extensive myocardial damage and delayed microvascular reperfusion...
  69. ncbi Long-term inhibition of myocardial infarction by postconditioning during reperfusion
    James Mykytenko
    Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center Crawford Long Hospital Emory University School of Medicine, 550 Peachtree Street NE, Atlanta, GA 30308 2225, USA
    Basic Res Cardiol 102:90-100. 2007
    ..p < 0.05 24 vs. 3 h control; p < 0.05 postconditioning vs. time-matched control...
  70. pmc Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions
    Orhan Maden
    Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
    Can J Cardiol 25:e164-8. 2009
    ..However, their relationship with reperfusion abnormalities is less clear...
  71. ncbi Reduction of "no-reflow" phenomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 6568, USA
    J Am Coll Cardiol 43:1291-8. 2004
    ..We hypothesized that IABC augmentation reduces the extent of microvascular obstruction after acute infarction...
  72. ncbi Primary percutaneous transluminal coronary angioplasty accelerates early myocardial reperfusion compared to thrombolytic therapy in patients with acute myocardial infarction
    Uwe Zeymer
    Medizinische Klinik II, Klinikum Kassel, Kassel, Germany
    Am Heart J 146:686-91. 2003
    ..The aim of this study was to compare early ST resolution in patients treated with primary percutaneous transluminal coronary angioplasty (PTCA) or thrombolytic therapy for AMI...
  73. ncbi Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion
    Erik Hedstrom
    Department of Clinical Physiology, Lund University, Lund, Sweden
    Scand Cardiovasc J 41:44-50. 2007
    ....
  74. ncbi Reperfusion arrhythmias: are they only a marker of epicardial reperfusion or continuing myocardial ischemia after acute myocardial infarction?
    Gulumser Heper
    Department of Cardiology, SSK Ihtisas Hospital, Etlik
    Angiology 58:663-70. 2007
    ..This finding suggests that the continuing myocardial ischemia represented by TIMI flow at the coronary angiography after acute myocardial infarction may have an important role in the pathogenesis of reperfusion arrhythmias...
  75. ncbi Sustained cardioprotection afforded by A2A adenosine receptor stimulation after 72 hours of myocardial reperfusion
    Matthieu Boucher
    Centre de biomédecine, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 45:439-46. 2005
    ..CREB activation and Hsp27 content do not seem to be associated with cardioprotection because they are enhanced in both treated groups, suggesting indirect A2A agonist and pathology-related effects...
  76. ncbi Ischemic postconditioning in pigs: no causal role for RISK activation
    Andreas Skyschally
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Circ Res 104:15-8. 2009
    ..In protocol 2, Wortmannin and U0126 blocked the increases in RISK phosphorylation during reperfusion, but infarct size was still smaller with IPoC (15+/-7%) than with IFR (35+/-6%; P<0.05)...
  77. ncbi Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: association with oxidative stress and its impact on myocardial reperfusion
    Kei Yunoki
    Department of Cardiology, Osaka City General Hospital, Osaka, Japan
    Eur Heart J 33:1480-90. 2012
    ..The purpose of this study was to determine the associations of red blood cell (RBC) component of coronary thrombi with oxidative stress and myocardial reperfusion.
  78. ncbi Mechanical prevention of distal embolization during primary angioplasty: safety, feasibility, and impact on myocardial reperfusion
    Ugo Limbruno
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Circulation 108:171-6. 2003
    Effective myocardial reperfusion after primary percutaneous coronary intervention (PCI) may be limited by distal embolization...
  79. ncbi Impact of minimising door-to-balloon times in ST-elevation myocardial infarction to less than 30 min on outcome: an analysis over an 8-year period in a tertiary care centre
    Ulrike M Müller
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Centre, Strumpellstrasse 39, Leipzig, Germany
    Clin Res Cardiol 100:297-309. 2011
    ..We hypothesised that DBT of <30 min can be accomplished for the majority of patients...
  80. ncbi Lethal myocardial reperfusion injury: a necessary evil?
    Borja Ibanez
    Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III C N I C, Madrid, Spain
    Int J Cardiol 151:3-11. 2011
    ..Currently, no intervention has been consistently shown to reduce reperfusion injury in large randomized multicenter trials, but the research in this field is intense and the future is highly promising...
  81. ncbi Time-dependent benefit of initial thrombosuction on myocardial reperfusion in primary percutaneous coronary intervention
    C L Chao
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Int J Clin Pract 62:555-61. 2008
    ..artery during primary percutaneous coronary intervention (PCI) may cause distal embolisation and impaired myocardial reperfusion. Clinical results of thromboembolic protection strategies have been controversial...
  82. ncbi Right bundle-branch block in anterior acute myocardial infarction in the coronary intervention era: acute angiographic findings and prognosis
    Satoshi Kurisu
    Department of Cardiology, Hiroshima City Hospital, 7 33, Moto machi, Naka ku, Hiroshima, 730 8518 Japan
    Int J Cardiol 116:57-61. 2007
    ..Previous studies in the prethrombolytic or thrombolytic era have reported that right bundle-branch block (RBBB) is associated with poor clinical outcome in patients with acute myocardial infarction (AMI)...
  83. ncbi Differentiating ST elevation myocardial infarction and nonischemic causes of ST elevation by analyzing the presenting electrocardiogram
    Jason B Jayroe
    University of Texas Medical Branch, Galveston, TX, USA
    Am J Cardiol 103:301-6. 2009
    ..There is a need to revise our current electrocardiographic criteria for differentiating STEMI from NISTE...
  84. pmc Transfer for urgent percutaneous coronary intervention early after thrombolysis for ST-elevation myocardial infarction: the TRANSFER-AMI pilot feasibility study
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, Canada
    Can J Cardiol 22:1121-6. 2006
    ..Urgent PCI after thrombolysis may optimize reperfusion and prevent reinfarction and recurrent ischemia...
  85. ncbi System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention
    Christian Juhl Terkelsen
    Department of Cardiology, Aarhus University Hospital, DK 8200 Aarhus N, Denmark
    JAMA 304:763-71. 2010
    ..No previous studies have focused on the association between system delay and outcome in patients with STEMI treated with primary PCI...
  86. ncbi Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy
    Tetsuji Miura
    Division of Cardiology, 2nd Dept of Internal Medicine, School of Medicine, Sapporo Medical University, South 1 West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Basic Res Cardiol 103:501-13. 2008
    ..Few agents have been thoroughly tested in clinically relevant animal models prior to their testing in man...
  87. ncbi Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling
    A K Jonassen
    Department of Medical Physiology, Institute of Medical Biology, , Norway
    Circ Res 89:1191-8. 2001
    ..Moreover, BAD is maintained in its inert phosphorylated state in response to insulin therapy...
  88. ncbi Signaling pathways in ischemic preconditioning
    James M Downey
    Department of Physiology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Heart Fail Rev 12:181-8. 2007
    ..The reperfused heart requires the support of the protective signals for only about an hour after which the ischemic injury is repaired and the signals are no longer needed...
  89. ncbi Acute treatment of myocardial infarction in Canada 1999-2002
    Cynthia A Jackevicius
    Pharmacy Department, University Health Network Toronto General Hospital, Toronto, Ontario M5G 2C4
    Can J Cardiol 21:145-52. 2005
    ..Therapy for management of acute myocardial infarction (AMI) varies according to patient, prescriber and geographical characteristics...
  90. ncbi Myocardial perfusion as assessed by positron emission tomography during long-term mechanical circulatory support
    George V Letsou
    Department of Cardiothoracic and Vasculay, The University of Texas Houston Medical School, Houston, TX, USA
    Congest Heart Fail 12:69-74. 2006
    ..These pilot study findings suggest that the decreased metabolic requirements induced by ventricular unloading correspondingly decreased blood flow requirements to physiologically inactive myocardium...
  91. ncbi Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Cardiovasc Res 55:739-48. 2002
    ..This study investigates the effect of NCX inhibition with KB-R7943 at the time of reperfusion on cell viability...
  92. pmc Optimal therapeutic strategies in the setting of post-infarct no reflow: the need for a pathogenetic classification
    L Galiuto
    Heart 90:123-5. 2004
  93. ncbi Use of emergency medical services in acute myocardial infarction and subsequent quality of care: observations from the National Registry of Myocardial Infarction 2
    John G Canto
    Chest Pain Center and Division of Cardiovascular Diseases, University of Alabama at Birmingham, 35294 0012, USA
    Circulation 106:3018-23. 2002
    ..We examined use of the EMS in the United States and ascertained the factors that may influence its use by patients with acute MI...
  94. ncbi Development of systems of care for ST-elevation myocardial infarction patients: evaluation and outcomes
    Eric D Peterson
    Circulation 116:e64-7. 2007
  95. ncbi Hypoxic conditioning suppresses nitric oxide production upon myocardial reperfusion
    Myoung Gwi Ryou
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Exp Biol Med (Maywood) 233:766-74. 2008
    ..Attenuation of the NOS/NO system may contribute to IHC-induced protection of myocardium from ischemia-reperfusion injury...
  96. ncbi Prediction of clinical outcome after mechanical revascularization in acute myocardial infarction by markers of myocardial reperfusion
    Philipp K Haager
    Medical Clinic I, University Hospital RWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Am Coll Cardiol 41:532-8. 2003
    ..We sought to evaluate and compare recently suggested parameters of reperfusion after angioplasty in acute myocardial infarction (AMI) for risk stratification during long-term follow-up...
  97. ncbi Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging
    Andreas H Mahnken
    Diagnostic Radiology, University Hospital, Pauwelsstrasse 30 D 52074 Aachen, Germany
    J Am Coll Cardiol 45:2042-7. 2005
    ..The aim of this study was to examine if contrast-enhanced multislice spiral computed tomography (MSCT) is comparable to contrast-enhanced magnetic resonance imaging (MRI) for depiction of acute myocardial infarction (MI)...
  98. pmc Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia
    Stig Muller
    Laboratory of Surgical Research, Institute of Clinical Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Crit Care 12:R20. 2008
    ..We hypothesised that restoring MAP by low dose, therapeutic level AVP would reduce vital organ blood flow in a setting of experimental acute left ventricular dysfunction...
  99. ncbi The paradigm of postconditioning to protect the heart
    C Penna
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Orbassano, Torino, Italy
    J Cell Mol Med 12:435-58. 2008
    ..Pharmacological PostC and possibly remote PostC may have a promising future in clinical scenario...
  100. ncbi High dose adenosine for suboptimal myocardial reperfusion after primary PCI: A randomized placebo-controlled pilot study
    Martin G Stoel
    Department of Cardiology, Medisch Spectrum Twente, Enschede, The Netherlands
    Catheter Cardiovasc Interv 71:283-9. 2008
    ..This study was designed to investigate the influence of high dose intracoronary adenosine on persistent ST-segment elevation after primary percutaneous coronary intervention (PCI)...
  101. ncbi Manual thrombus-aspiration improves myocardial reperfusion: the randomized evaluation of the effect of mechanical reduction of distal embolization by thrombus-aspiration in primary and rescue angioplasty (REMEDIA) trial
    Francesco Burzotta
    Institute of Cardiology, Catholic University, Rome, Italy
    J Am Coll Cardiol 46:371-6. 2005
    ..The aim of this study was to evaluate the use of a new manual thrombus-aspirating device in unselected patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing urgent percutaneous coronary intervention (PCI)...

Research Grants62

  1. Peroxynitrite in Cardiac Ischemia/Reperfusion
    Xin Liang Ma; Fiscal Year: 2010
    ..for myocardial apoptosis after MI/R, and to search for the optimal therapeutic strategies that will reduce myocardial reperfusion injury...
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..The injury culminates in the death of cardiomyocytes that were viable immediately before myocardial reperfusion and occurs despite timely reperfusion and can increase infarct size (1)...
  3. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..If we can avoid the untimely presence of these cells in ischemia, heart failure after myocardial infarction would then be diminished. ..
  4. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2010
    ..We propose that myocardial reperfusion injury to the endothelium will be modest in TNF-alpha knockout (TNF-/-) mice, severe in TNF-alpha over-..
  5. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Myocardial reperfusion following a period of ischemia may be regarded as a "mixed blessing...
  6. Mechanisms of photobiomodulation in myocardial reperfusion injury
    Martin Bienengraeber; Fiscal Year: 2013
    ..Importantly, the use of NIR for reperfusion injury has the potential for rapid translation to the clinic given its relatively safe profile. ..
  7. An Innovative Cardioprotective
    Prakash Narayan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Myocardial infarction remains a significant cause of morbidity and mortality. A cardioprotective agent that reduces infarct size and salvages myocardium can avert the transition to pump failure. ..
  8. Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and Autophagy
    David E Sosnovik; Fiscal Year: 2012
    ..By using these techniques we aim to better understand how programmed CM death occurs during myocardial reperfusion and how to prevent this...
  9. High-Throughput Screen for Small Molecules that Modulate Myocardial Damage
    Richard N Kitsis; Fiscal Year: 2012
    ..Prompt myocardial reperfusion via angioplasty/stenting is currently the optimal treatment, but its effectiveness is limited by a narrow ..
  10. REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAY
    CHARLES COLLARD; Fiscal Year: 2001
    ..adhesion molecules (ICAM-1); and 3) in vivo inhibition of the lectin complement pathway attenuates myocardial reperfusion injury...
  11. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury...
  12. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..These studies will provide important information regarding the role of ENDOTHELIN in myocardial reperfusion injury and whether modulation of this peptide accounts for the beneficial effects of ADENOSINE on ..
  13. MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1991
    ..These studies will provide important information regarding the mechanisms of reperfusion injury in the canine model and the usefullness of various agents to limit this entity...
  14. HUMAN N FORMYL PEPTIDE RECEPTOR--REGULATION AND GENETICS
    David Haviland; Fiscal Year: 2000
    ..pathogenesis of many diseases including adult respiratory distress syndrome (ARDS), rheumatoid arthritis, myocardial reperfusion injury, and inflammatory bowel disease...
  15. PREVENTION OF ORGAN INJURY DURING CARDIOPULMONARY BYPASS
    DUKE CAMERON; Fiscal Year: 1993
    ..sCR1) is a potent inhibitor of complement activation produced by recombinant DNA techniques sCR1 reduces myocardial reperfusion injury in animal models...
  16. PEROXYNITRITE AS MYOCARDIAL PROTECTIVE AGENTS
    Laszlo Virag; Fiscal Year: 2000
    ..and vascular smooth muscle cells, that peroxynitrite, and hydrogen peroxide, potent oxidants produced in myocardial reperfusion injury, trigger a cascade culminating in cellular energetic failure and cell death (necrosis and apoptosis)..
  17. Cytochrome P450 in Reperfusion Injury
    Roberta Gottlieb; Fiscal Year: 2007
    ..This proposal identifies cytochrome P450 monooxygenases as a previously underestimated factor in myocardial reperfusion injury, and establishes the basis for a novel therapeutic approach [unreadable] [unreadable]
  18. ULTRAPOTENT PARS INHIBITOR FOR CARDIOPROTECTION
    John van Duzer; Fiscal Year: 2000
    ..Peroxynitrite, and hydrogen peroxide, potent oxidants produced in myocardial reperfusion injury, trigger a cascade culminating in cellular energetic failure...
  19. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2005
    ..our studies on the role of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in the pathogenesis of myocardial reperfusion injury...
  20. Modified Late Infarct Reperfusion to Prevent Post MI CHF
    Robert Gorman; Fiscal Year: 2006
    ..It is not the central focus of this proposal to explore the mechanism of myocardial reperfusion injury (although the apoptosis studies will provide new information on how this unique form of cell death ..
  21. SCOR IN ISCHEMIC HEART DISEASE
    Lewis Becker; Fiscal Year: 1999
    ..the role of the endothelium in promoting early neutrophil (PMN) targeting and possible PMN- mediated myocardial reperfusion injury...
  22. MECHANISMS OF NEUTROPHIL-DEPENDENT VASCULAR DAMAGE
    Stephen Weiss; Fiscal Year: 1993
    ..states ranging from immune vasculitis and respiratory distress syndromes to atherosclerotic disease and myocardial reperfusion injury...
  23. MITOCHONDRIA AND ETHANOL DEPENDENT CARDIOPROTECTION
    Victor Darley Usmar; Fiscal Year: 2001
    ..The information gained from the accomplishment of these specific aims will give insight into the mechanisms of alcohol in cardioprotection through NO-dependent mechanisms. ..
  24. Mechanism of Myocardial Reperfusion Injury in Diabetes
    David Lefer; Fiscal Year: 2008
    ..effects of NO therapy on home oxygenase-1 (HO-1) activation and myocardial protection in the setting of myocardial reperfusion injury in the diabetic heart...
  25. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  26. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  27. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  28. Tissue Factor in Myocardial Reperfusion
    Jakob Vinten Johansen; Fiscal Year: 2006
    ..abstract_text> ..
  29. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..inhibition of PARS on endothelial injury and neutrophil accumulation will be studied in a rat model of myocardial reperfusion injury...
  30. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  31. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..Using this model, we propose that a class of drugs used in diabetic patients that has been associated with heart failure exacerbations, alters the mitochondrial energy production in a similar way. ..
  32. Inhomogeneous Sympathetic Innervation in IHD
    JAMES FALLAVOLLITA; Fiscal Year: 2008
    ..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
  33. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2002
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  34. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  35. EXTRAVASCULAR TRAFFICKING OF HIV+ CELLS AND PROGNOSIS
    Holly Birdsall; Fiscal Year: 2003
    ....
  36. Hormonal Opioids in Ischemic Preconditioning
    Eric Dickson; Fiscal Year: 2005
    ..Dickson with the facilities, equipment and expertise necessary to achieve the goals set forth in this proposal...
  37. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2003
    ....
  38. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
  39. The Natural History of Venous Thromboembolism in the Elderly
    Frederick A Spencer; Fiscal Year: 2010
    ..We will also examine how elderly patients with venous thromboembolism are currently being treated, whether some patients are at risk for inappropriate or under treatment, and the relationship of treatment to future complications. ..
  40. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001
    ..This study will provide important insights into the phenotypic and genetic determinants of clinical and occult CHD in families with premature CHD. ..
  41. MAGNETIC RESONANCE CORONARY ANGIOGRAPHY
    John Oshinski; Fiscal Year: 2001
    ....
  42. Preconditioning Improves Coronary Patency
    Karin Przyklenk; Fiscal Year: 2007
    ..The resulting mechanistic insights may, ultimately, be exploited in the future design of novel therapies for the clinical treatment of recurrent thrombosis. ..
  43. Glomerular Filtration Rate Test
    Christopher Reinhardt; Fiscal Year: 2008
    ..The test will utilize FDA-cleared compounds that are known to be GFR markers. As a result, our proposed GFR test will be able to more quickly enter the marketplace. ..
  44. Coronary Disease Detection by Thalluim SPECT and Fast CT
    Lewis Becker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  45. Aging Heart and Vessels (International Conference)
    James Downey; Fiscal Year: 2004
    ..7. To give governments a summary of new research findings and potential for the future that may contribute to health planning and problem solving from community to nation level. 8. To publish the proceedings as a public record. ..
  46. MICROVASC OBSTRUCTION BY MRI AFTER CORONARY INTERVENTION
    Katherine Wu; Fiscal Year: 2004
    ..However, an open epicardial coronary artery is not necessarily equivalent to optimal myocardial reperfusion. Despite a widely patent artery, complete reperfusion at the myocardial level may not occur because of ..
  47. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
  48. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  49. The ER Stress Response and ATF6 Activation in the Heart
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007
    ..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
  50. Mechanisms of Cardioprotection
    Roberto Bolli; Fiscal Year: 2007
    ....
  51. MESA Family Study
    Karol Watson; Fiscal Year: 2007
    ..abstract_text> ..
  52. Glucolipotoxicity and Cardiac Dysfunction in Obesity
    Heinrich Taegtmeyer; Fiscal Year: 2007
    ..abstract_text> ..
  53. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  54. Aging, Adenosine and Platelet-Mediated Thrombosis
    Karin Przyklenk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Hibernating Myocardium and Sudden Cardiac Death
    JOHN CANTY; Fiscal Year: 2008
    ..Our long-term objective is to develop better approaches to identify patients with CAD who are most likely to benefit from primary prevention of SCD with placement of an ICD. [unreadable] [unreadable]..
  56. Magnetic resonance angiography
    Christopher Reinhardt; Fiscal Year: 2008
    ..abstract_text> ..
  57. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  58. Genome-Wide Association of Platelet Phenotypes
    Lewis Becker; Fiscal Year: 2009
    ..This study represents the first genome -wide SNP association study of comprehensive platelet function and should lead to novel tailored anti-platelet therapy for the prevention of vascular thromboses. (End of Abstract) ..