Summary: Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.

Top Publications

  1. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
  2. ncbi Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
    G A Rosenberg
    Departments of Neurology, Cell Biology and Physiology, and Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 29:2189-95. 1998
  3. ncbi Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion
    Thomas Pfefferkorn
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    Stroke 34:2025-30. 2003
  4. pmc MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study
    Maarten G Lansberg
    Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA, USA
    Lancet Neurol 11:860-7. 2012
  5. ncbi Vascular ischaemia and reperfusion injury
    Holger K Eltzschig
    Clinical Associate Department of Cardiovascular Anesthesia, Texas Heart Institute, St Luke s Episcopal Hospital, 6720 Bertner Avenue, Room 0520, MC1 226, Houston, TX 77030, USA
    Br Med Bull 70:71-86. 2004
  6. pmc Renal hypoxia and dysoxia after reperfusion of the ischemic kidney
    Matthieu Legrand
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Med 14:502-16. 2008
  7. pmc Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice
    Nozomu Sakai
    Department of Surgery, University of Cincinnati, Cincinnati, OH 45267 0558, USA
    Hepatology 56:1468-78. 2012
  8. ncbi Photothrombotic middle cerebral artery occlusion and reperfusion laser system in spontaneously hypertensive rats
    Hiroshi Yao
    Department of Medicine and Clinical Science, Second Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Stroke 34:2716-21. 2003
  9. ncbi Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats
    Heng Zhao
    Department of Neurosurgery, Stanford University, California 94305 5327, USA
    J Cereb Blood Flow Metab 26:1114-21. 2006
  10. doi Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats
    Tomohiro Kawamura
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1344-51. 2010

Detail Information

Publications299 found, 100 shown here

  1. pmc Ischemia and reperfusion--from mechanism to translation
    Holger K Eltzschig
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado, Aurora, Colorado, USA
    Nat Med 17:1391-401. 2011
    Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease ..
  2. ncbi Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
    G A Rosenberg
    Departments of Neurology, Cell Biology and Physiology, and Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 29:2189-95. 1998
    b>Reperfusion disrupts cerebral capillaries, causing cerebral edema and hemorrhage. Middle cerebral artery occlusion (MCAO) induces the matrix-degrading metalloproteinases, but their role in capillary injury after reperfusion is unknown...
  3. ncbi Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion
    Thomas Pfefferkorn
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    Stroke 34:2025-30. 2003
    ..We hypothesized that rtPA-mediated adverse effects depend on the timing of reperfusion and injury to the blood-brain barrier (BBB).
  4. pmc MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study
    Maarten G Lansberg
    Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA, USA
    Lancet Neurol 11:860-7. 2012
    ..We aimed to establish whether MRI can be used to identify patients who are most likely to benefit from endovascular reperfusion.
  5. ncbi Vascular ischaemia and reperfusion injury
    Holger K Eltzschig
    Clinical Associate Department of Cardiovascular Anesthesia, Texas Heart Institute, St Luke s Episcopal Hospital, 6720 Bertner Avenue, Room 0520, MC1 226, Houston, TX 77030, USA
    Br Med Bull 70:71-86. 2004
    Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible tissue injury, reperfusion per se may result in a local and systemic inflammatory response that may augment tissue injury in excess of that ..
  6. pmc Renal hypoxia and dysoxia after reperfusion of the ischemic kidney
    Matthieu Legrand
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Med 14:502-16. 2008
    ..may be ineffective in more severe cases and lead to the development of chronic renal failure following ischemia-reperfusion. This paper is aimed at reviewing the current insights into oxygen transport pathways, from oxygen supply to ..
  7. pmc Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice
    Nozomu Sakai
    Department of Surgery, University of Cincinnati, Cincinnati, OH 45267 0558, USA
    Hepatology 56:1468-78. 2012, we sought to determine whether IL-33 is an important regulator in the hepatic response to ischemia/reperfusion (I/R)...
  8. ncbi Photothrombotic middle cerebral artery occlusion and reperfusion laser system in spontaneously hypertensive rats
    Hiroshi Yao
    Department of Medicine and Clinical Science, Second Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Stroke 34:2716-21. 2003
    To establish a less invasive and reproducible focal ischemia model in the rat, we adopted a 2-laser system (ie, photothrombosis and YAG laser-induced reperfusion).
  9. ncbi Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats
    Heng Zhao
    Department of Neurosurgery, Stanford University, California 94305 5327, USA
    J Cereb Blood Flow Metab 26:1114-21. 2006
    ..b>Reperfusion plays a critical role in cerebral injury after stroke; we tested the hypothesis that interrupting reperfusion ..
  10. doi Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats
    Tomohiro Kawamura
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1344-51. 2010
    Successful abrogation of ischemia/reperfusion (I/R) injury of lung grafts could significantly improve short- and long-term outcomes for lung transplant (LTx) recipients...
  11. ncbi Reduction and restoration of mitochondrial dna content after focal cerebral ischemia/reperfusion
    H Chen
    Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 32:2382-7. 2001
    ..AND PURPOSE: Oxidative damage of mitochondrial DNA (mtDNA) in the ischemic brain is expected after ischemia/reperfusion injury. A recent study demonstrated limited patterns of mtDNA deletion in the brain after ischemia/reperfusion...
  12. pmc RAPID automated patient selection for reperfusion therapy: a pooled analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study
    Maarten G Lansberg
    Stanford University, Stanford Stroke Center, 780 Welch Road, Suite 205, Palo Alto, CA 94304, USA
    Stroke 42:1608-14. 2011
    The aim of this study was to determine if automated MRI analysis software (RAPID) can be used to identify patients with stroke in whom reperfusion is associated with an increased chance of good outcome.
  13. ncbi Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
    Zhi Fei Wang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
    Pharmacol Biochem Behav 83:603-11. 2006
    ..A on memory deficits, neuronal damage and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice, as well as the potential downstream signaling pathway...
  14. ncbi Effect of ascorbic acid supplementation on certain oxidative stress parameters in the post reperfusion patients of myocardial infarction
    Pushpa Bhakuni
    Department of Biochemistry, Lucknow University, Lucknow 226007, India
    Mol Cell Biochem 290:153-8. 2006
    b>Reperfusion injury causes oxidative stress thereby resulting in an imbalance between oxidant-antioxidant systems...
  15. ncbi Inhaled nitric oxide attenuates reperfusion inflammatory responses in humans
    Mali Mathru
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Anesthesiology 106:275-82. 2007
    Reduced bioavailability of endothelium-derived nitric oxide associated with reperfusion could potentially exacerbate the inflammatory response during reperfusion...
  16. ncbi Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion
    S Ashwal
    Department of Pediatrics, Loma Linda University School of Medicine, Calif 92354, USA
    Stroke 29:1037-46; discussion 1047. 1998
    ..The present studies examined the hypothesis that the distribution of cerebral injury after a focal ischemic insult is associated with the regional distribution of nitric oxide synthase (NOS) activity...
  17. ncbi Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice
    Yasuo Ito
    Department of Neurology, School of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350 0495, Japan
    Curr Neurovasc Res 7:23-31. 2010
    ..changes to hippocampal CA1 neurons in eNOS knockout (-/-) mice and nNOS (-/-) mice during cerebral ischemia and reperfusion. NO production was continuously monitored by in vivo microdialysis...
  18. pmc Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia
    Philip A Barber
    Department of Clinical Neurosciences, Experimental Imaging Centre and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Canada
    BMC Neurosci 13:76. 2012
    ..Images were acquired starting at 2 or 24 hours after reperfusion over the ipsilateral and contralateral cortex before and for 3 hours after, MMPSense750 was injected.
  19. ncbi Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes
    Natalia N Nalivaevaa
    School of Biochemistry and Microbiology, University of Leeds, UK
    Ann N Y Acad Sci 1035:21-33. 2004 the model of four-vessel occlusion ischemia in rats with their restoration to the control levels after reperfusion. Preconditioning to mild hypoxia both in the prenatal period and in adults appeared to have a neuroprotective ..
  20. doi Characterizing photothrombotic distal middle cerebral artery occlusion and YAG laser-induced reperfusion model in the Izumo strain of spontaneously hypertensive rats
    Hiroshi Yao
    National Hospital Organization Hizen Psychiatric Center, Saga, Japan
    Cell Mol Neurobiol 31:57-63. 2011
    ..were subjected to photothrombotic middle cerebral artery (MCA) occlusion with or without YAG laser-induced reperfusion. The pattern of distal MCA was recorded...
  21. ncbi Prevention of ischemia-reperfusion injury in rat ovarian tissue with the on-off method
    M Ingec
    Ataturk University, Medical Faculty, Department of Obstetrics and Gynecology, Erzurum, Turkiye
    J Physiol Pharmacol 62:575-82. 2011
    ..The positive effects of controlled reperfusion are known and are used clinically...
  22. doi Reperfusion for acute ischemic stroke: arterial revascularization and collateral therapeutics
    David S Liebeskind
    UCLA Stroke Center, Los Angeles, California 90095, USA
    Curr Opin Neurol 23:36-45. 2010
    b>Reperfusion of the ischemic territory forms the basis of most acute stroke treatments...
  23. doi Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats
    Huiling Cao
    School of Medical Science and Laboratory Medicine, Center for Clinical Laboratory Medicine of Affiliated Hospital, Jiangsu University, Zhenjiang Key Institute of Clinical Laboratory Medicine, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People s Republic of China
    Biotechnol Lett 32:725-32. 2010
    ..The results lay the foundation for further study on the potential application of UC-MSC in human disease...
  24. doi Matrix metalloproteinase-9 (MMP-9) expression and extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation in exercise-reduced neuronal apoptosis after stroke
    Khawar Chaudhry
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Neurosci Lett 474:109-14. 2010
    Exercise preconditioning has been shown to reduce neuronal damage in ischemic/reperfusion (I/R) injury. ERK1/2 signaling in injury has been thought to modulate neuroprotection...
  25. ncbi Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm
    Stavros P Loukogeorgakis
    Vascular Physiology Unit, Institute of Child Health, University College London, London, WC1N 3JE, United Kingdom
    Circulation 113:1015-9. 2006
    ..Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury...
  26. doi Urinary trypsin inhibitor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats
    Yasutaka Koga
    Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Japan
    Neurol Res 32:925-32. 2010
    ..the effects of ulinastatin, a urinary trypsin inhibitor (UTI), on jugular venous superoxide radical (O₂⁻·) generation, oxidative stress, early inflammation, and endothelial activation in forebrain ischemia/reperfusion (FBI/R) rats.
  27. doi A pilot study of rapid cooling by cold saline and endovascular cooling before reperfusion in patients with ST-elevation myocardial infarction
    Matthias Götberg
    Department of Coronary Heart Disease, Skane University Hospital, Lund University, Lund, Sweden
    Circ Cardiovasc Interv 3:400-7. 2010
    Experimental studies have shown that induction of hypothermia before reperfusion of acute coronary occlusion reduces infarct size...
  28. pmc Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial
    Pooja Khatri
    University of Cincinnati, Cincinnati, OH, USA Electronic address
    Lancet Neurol 13:567-74. 2014
    ..Late reperfusion of tissue that was no longer salvageable could be one explanation, as suggested by previous exploratory studies ..
  29. ncbi Reperfusion syndrome: cellular mechanisms of microvascular dysfunction and potential therapeutic strategies
    Hardev Ramandeep Singh Girn
    Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK
    Vasc Endovascular Surg 41:277-93. 2007
    b>Reperfusion injury is the paradoxical and complex phenomenon of exacerbation of cellular dysfunction and increase in cell death after the restoration of blood flow to previously ischemic tissues...
  30. ncbi Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice
    Yuji Tanaka
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Mol Pharmacol 71:817-25. 2007
    Hepatic ischemia-reperfusion (IR) results in Kupffer cell activation and subsequent tumor necrosis factor (TNF) alpha release, leading to localized hepatic injury and remote organ dysfunction...
  31. doi Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo
    Richard Ingemansson
    Department of Cardiothoracic Surgery, Heart Lung Division, Lund University Hospital, Lund, Sweden
    Ann Thorac Surg 87:255-60. 2009
    ..Only about 20% of donor lungs are accepted for transplantation. A method to evaluate and recondition lungs ex vivo has been tested on donor lungs that have been rejected for transplantation...
  32. doi Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
    Toru Yamashita
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cereb Blood Flow Metab 29:715-25. 2009
    In the ischemic brain, reperfusion with tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT); however, the mechanism remains elusive...
  33. pmc Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion
    Hai Chen
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cereb Blood Flow Metab 29:1262-72. 2009
    ..Superoxide radicals play a significant role in brain ischemia-reperfusion (I/R) injury. Recent data have also shown expression of NOX in the brain...
  34. doi Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury
    Takeshi Oyaizu
    Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, ON, Canada
    Intensive Care Med 38:894-905. 2012
    Pulmonary ischemia-reperfusion is a pathological process seen in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation for circulatory arrest, atherosclerosis, and pulmonary embolism...
  35. doi "Picture to puncture": a novel time metric to enhance outcomes in patients transferred for endovascular reperfusion in acute ischemic stroke
    Chung Huan J Sun
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Circulation 127:1139-48. 2013
    ..Efficacy of endovascular treatments, however, may be limited by delays in patient transfer. Our goal was to identify where these delays occurred and to assess the impact of such delays on patient outcome...
  36. doi Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs
    Stefania Momi
    Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Blood 121:5088-97. 2013
    ..ALX-0081 prevented MCA thrombosis and induced reperfusion when given immediately after and 15 minutes after complete occlusion and reduced brain damage without inducing ..
  37. doi Ischemic postconditioning attenuates renal ischemic/reperfusion injury in mongrel dogs
    Botao Jiang
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China
    Urology 76:1519.e1-7. 2010
    To investigate the effect of Postcond on renal ischemia-reperfusion (I/R) injury in a canine model. I/R injury is the most common cause of renal dysfunction...
  38. doi The expression and activity of brain lipoprotein lipase is increased after acute cerebral ischemia-reperfusion in rats
    Xiaojuan Wang
    Institute of Neurosciences, The 2nd Affiliated Hospital of Guangzhou Medical College, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Guangzhou, China
    Neuropathology 30:131-9. 2010 was to determine the response of expression and activity of brain LPL following acute cerebral ischemia-reperfusion. Adult male Sprague-Dawley rats were subjected to surgical occlusion of the middle cerebral artery...
  39. ncbi Astroglial expression of the beta-amyloid in ischemia-reperfusion brain injury
    Ryszard Pluta
    Department of Neuropathology, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5 Str, 02 106 Warsaw, Poland
    Ann N Y Acad Sci 977:102-8. 2002
    ..After reperfusion for 2, 7, and 14 days and 1, 6, 9, and 12 months, brains were immunostained...
  40. ncbi Enhancement of endogenous fibrinolysis does not reduce local fibrin deposition, but modulates inflammation upon intestinal ischemia and reperfusion
    Ivo G Schoots
    Department of Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Thromb Haemost 91:497-505. 2004
    ..and increased fibrin deposition to intestinal dysfunction and injury in a rat model of intestinal ischemia/reperfusion (I/R), as fibrinolytic inhibition may lead to thrombotic obstructions that compromise microcirculation and ..
  41. doi Reperfusion-induced temporary appearance of therapeutic window in penumbra after 2 h of photothrombotic middle cerebral artery occlusion in rats
    Hiroshi Yao
    Laboratory for Neurochemistry, Center for Emotional and Behavioral Disorders, National Hospital Organization, Hizen psychiatric Center, Saga, Japan
    J Cereb Blood Flow Metab 29:565-74. 2009
    To explore the effects of reperfusion on evolution of focal ischemic injury, spontaneously hypertensive male rats were subjected to photothrombotic distal middle cerebral artery occlusion (MCAO) with or without YAG laser-induced ..
  42. doi Anti-arrhythmic effects of kappa-opioid receptor and its changes in ischemia and reperfusion
    Liu Jin-Cheng
    Department of Physiology, National Key Discipline of Cell Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Arch Med Res 39:483-8. 2008
    It remains unclear whether the kappa-opioid receptor (kappa-OR) is altered during ischemia and reperfusion. Therefore, the present study was designed to investigate changes in the kappa-OR...
  43. doi Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis
    Oumei Cheng
    Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
    Brain Res 1470:111-8. 2012
    ..Recent studies indicate that the excessive inflammatory response induced by cerebral ischemia/reperfusion plays an important role in ischemic damage...
  44. ncbi Ischaemic preconditioning improves microvascular perfusion and oxygenation following reperfusion injury of the intestine
    I H Mallick
    Gastrointestinal and Hepatobiliary Research Unit, University Department of Surgery, Royal Free and University College Medical School, University College London, UK
    Br J Surg 92:1169-76. 2005
    Ischaemia-reperfusion (IR) injury of the intestine occurs commonly during abdominal surgery. Ischaemic preconditioning (IPC) provides a way of protecting the organ from damage inflicted by IR...
  45. pmc Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 107:1196-205. 2008
    ..5 h reperfusion. Inhibition of NADPH oxidase with apocynin reduced the MMP-9 increase, indicating a causal link between NADPH ..
  46. doi Expression of bystin in reactive astrocytes induced by ischemia/reperfusion and chemical hypoxia in vitro
    Du Fang
    Department of Neurobiology and Neurochemistry, Institute for Nautical Medicine and Jiangsu Key Laboratory of Neurogeneration, Nantong University, Nantong 226001, PR China
    Biochim Biophys Acta 1782:658-63. 2008
    In this study, we investigated the effects of ischemia/reperfusion and chemical hypoxia on the morphology, cell viability and expression of bystin and glial fibrillary acidic protein (GFAP) in primary cultured astrocytes which were ..
  47. doi Dual Effect of low-level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: Action on anti- and pro-inflammatory cytokines
    F Mafra de Lima
    Research and Development Institute, Av Shishima Hifumi, 2911, Sao Jose dos Campos, SP, Brazil
    Lasers Surg Med 43:410-20. 2011
    It is unknown if pro- and anti-inflammatory mediators in acute lung inflammation induced by intestinal ischemia and reperfusion (i-I/R) can be modulated by low-level laser therapy (LLLT).
  48. pmc Reperfusion of specific cortical areas is associated with improvement in distinct forms of hemispatial neglect
    Shaan Khurshid
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cortex 48:530-9. 2012
  49. pmc Investigation of reperfusion injury and ischemic preconditioning in microsurgery
    Wei Zhong Wang
    Department of Surgery, Division of Plastic Surgery, University of Nevada School of Medicine, Las Vegas, NV 89102, USA
    Microsurgery 29:72-9. 2009
    Ischemia/reperfusion (I/R) is inevitable in many vascular and musculoskeletal traumas, diseases, free tissue transfers, and during time-consuming reconstructive surgeries in the extremities...
  50. doi Protective effect of erythropoietin pretreatment in testicular ischemia-reperfusion injury in rats
    Bekir Ugur Ergur
    Department of Histology and Embryology, Dokuz Eylul University Medical School, Balcova, Izmir 35340, Turkey
    J Pediatr Surg 43:722-8. 2008
    This study was designed to investigate the effects of recombinant erythropoietin (EPO), a hormone widely used for treatment of uremic anemia, in rats subjected to testicular ischemia and reperfusion (I/R).
  51. ncbi Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion
    Aaron M Hamby
    Department of Neurology, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California, USA
    Stroke 38:632-6. 2007
    ..We evaluated the effects of PJ34 administered 8 hours after transient forebrain ischemia...
  52. doi Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion
    D H Liu
    Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center of Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, China
    Neuroscience 229:36-48. 2013
    ..Here we reported ASK1 was activated by nitric oxide (NO) through S-nitrosylation during cerebral ischemia-reperfusion. The reagents that abrogate neuronal nitric oxide synthase (nNOS) activity such as nNOS inhibitor 7NI and N-..
  53. ncbi Gallium-desferrioxamine protects the cat retina against injury after ischemia and reperfusion
    E Banin
    Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel
    Free Radic Biol Med 28:315-23. 2000
    ..biochemical and electrophysiological parameters of injury in the cat retina subjected to ischemia followed by reperfusion. For the biochemical studies, cat eyes were subjected to 90 min of retinal ischemia followed by 5 min of ..
  54. ncbi Experimental renal preservation by normothermic resuscitation perfusion with autologous blood
    A Bagul
    Department of Transplant Surgery, University Hospitals of Leicester, Leicester, UK
    Br J Surg 95:111-8. 2008
    ..This study investigated the effects of NP compared with current methods of organ preservation in a model of controlled non-heart-beating donor (NHBD) kidneys...
  55. ncbi Mouse model of in situ thromboembolic stroke and reperfusion
    Cyrille Orset
    INSERM Avenir tPA in the working brain, University of Caen, Centre Cyceron, Bd Becquerel, BP 5229, 14074 Caen Cedex, France
    Stroke 38:2771-8. 2007
    Early reperfusion using tissue-type plasminogen activator is the only therapeutic agent to treat focal cerebral ischemia with proven efficacy in patients...
  56. ncbi Protection by cyclosporin A of mitochondrial and cellular functions during a cold preservation-warm reperfusion of rat liver
    Catherine Plin
    Laboratoire de Pharmacologie, Faculte de Medecine, Universite Paris XII, France
    Eur J Pharmacol 495:111-8. 2004
    ..end-stage liver disease, but initial poor graft function still occurs, often related to cold preservation-warm reperfusion (CPWR) conditions...
  57. ncbi Differential effects of ischemia/reperfusion on amacrine cell subtype-specific transcript levels in the rat retina
    Frederike Dijk
    Netherlands Ophthalmic Research Institute KNAW, Glaucoma Research Group, Research Unit Molecular Ophthalmogenetics, Graduate School for the Neurosciences Amsterdam, Meibergdreef 47, Amsterdam 1105 BA, The Netherlands
    Brain Res 1026:194-204. 2004
    ..A 60-min ischemic period was administered to the rat eye by raising the intraocular pressure, followed by a reperfusion period lasting between 2 h and 4 weeks...
  58. doi Comparison of 5 different remifentanil strategies against myocardial ischemia-reperfusion injury
    Kook Jin Chun
    Institute of Cardiovascular Research, Pusan National University Yangsan Hospital, Gyeongsangnam do, Republic of Korea
    J Cardiothorac Vasc Anesth 25:926-30. 2011
    The purpose of this study was to investigate the effects of various remifentanil strategies (preconditioning, postconditioning, or continuous infusion) against myocardial ischemia-reperfusion injury.
  59. ncbi Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion
    Jing Lan
    Department of Neurology and Pittsburgh Institute of Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 23:1324-39. 2003
    To determine the role of oxidative DNA damage and repair in brain injury after focal ischemia and reperfusion, the authors investigated DNA base damage and DNA base excision repair (BER) capacity, the predominant repair mechanism for ..
  60. doi Cyclic-AMP response element binding protein and tau are involved in the neuroprotective mechanisms of nerve growth factor during focal cerebral ischemia/reperfusion in rats
    Zheng Hong Zhang
    Department of Neurology, Affiliated Renmin Hospital, Yunyang Medical College, Shiyan, Liaoning, China
    J Clin Neurosci 17:353-6. 2010
    ..We explored the protective mechanism of exogenous NGF on rat hippocampal neurons after focal cerebral ischemia/reperfusion. Changes were detected in the expression of cyclic-adenosine monophosphate (AMP) response element binding ..
  61. ncbi Cell proliferation and death of growth plate chondrocyte caused by ischemia and reperfusion
    T Matsuno
    Department of Orthopaedic Surgery, Hiroshima University School of Medicine, Japan
    Microsurgery 21:30-6. 2001
    ..the short-term response of cell kinetics of growth plate chondrocytes under conditions of warm ischemia and reperfusion. To understand the time-course changes that occur after reperfusion, 0 and 6 h of warm ischemia was produced in ..
  62. pmc Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion
    J Gamboa
    Department of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Neuroscience 170:846-57. 2010
    ..find that pioglitazone reduces infarction volume in a transient, but not a permanent MCAO model suggesting that reperfusion plays an important role in TZD mediated neuroprotection...
  63. ncbi Intermittent hepatic ischemia-reperfusion minimizes liver metastasis in rats
    Makoto Yoshida
    Second Department of Surgery, Fukui Medical University, Fukui, Japan
    J Surg Res 111:255-60. 2003
    Surgical stresses, including hepatic ischemia-reperfusion (I/R), promote cancer growth and metastasis...
  64. ncbi Pancreatic proteases and inflammatory mediators in peritoneal fluid during splanchnic arterial occlusion and reperfusion
    Kei Ishimaru
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Shock 22:467-71. 2004
    ..of inflammatory mediators in the peritoneal cavity in response to splanchnic arterial occlusion (90 min) and reperfusion (SAO shock), we measured the ability of fluid collected from this cavity to activate naive donor granulocytes...
  65. doi Retinal neuroprotection against ischemia-reperfusion damage induced by postconditioning
    Diego C Fernandez
    Departamento de Bioquimica Humana, Universidad de Buenos Aires, CEFYBO CONICET, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 50:3922-30. 2009
    ..The authors investigated whether brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia-reperfusion damage.
  66. ncbi Hepatic injury and lipid peroxidation during ischemia and reperfusion
    S M Lee
    College of Pharmacy, Sungkyunkwan University, Suwon, Korea
    Shock 13:279-84. 2000
    ..and alterations in hepatic secretory and microsomal function during various periods of hepatic ischemia/reperfusion. Rats were pretreated with alpha-tocopherol or vehicle and then subjected to 30, 60, and 90 min, no-flow ..
  67. ncbi Cytokine patterns after tourniquet-induced skeletal muscle ischaemia reperfusion in total knee replacement
    T Clementsen
    Department of Orthopaedics, Rikshospitalet Radiumhospitalet Medical Centre, University of Oslo, Oslo, Norway
    Scand J Clin Lab Invest 68:154-9. 2008 performed under tourniquet control causes one of the most common forms of skeletal muscle ischaemia-reperfusion injury in clinical practice...
  68. ncbi Co-expression of endothelin-1 and vascular endothelial growth factor mediates increased vascular permeability in lung grafts before reperfusion
    Shahrokh Taghavi
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    J Heart Lung Transplant 21:600-3. 2002
    ..ET-1 mRNA and VEGF-A protein levels as well as increased fluid content in donor lung-tissue biopsies before reperfusion. Hypoxia and ET-1 co-upregulate VEGF-A overexpression, therefore temporary VEGF-A antagonism during graft ..
  69. ncbi Cardiac proteasome dysfunction during cold ischemic storage and reperfusion in a murine heart transplantation model
    Matthias Majetschak
    DeWitt Daughtry Family Department of Surgery, Divisions of Trauma and Surgical Critical Care Trauma Research and Cardiothoracic Surgery, University of Miami Miller School of Medicine, 1800 NW 10th Avenue, Miami, FL 33136, USA
    Biochem Biophys Res Commun 365:882-8. 2008
    ..suggest that the ubiquitin-proteasome system (UPS) contributes to the pathophysiology of myocardial ischemia-reperfusion injury...
  70. ncbi Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation
    Kristin Engelhard
    Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Anesthesiology 101:912-7. 2004
    ..This study investigates the long-term effects of propofol on neuronal damage and apoptosis-related proteins after cerebral ischemia and reperfusion.
  71. ncbi Alkaline phosphatase reduces hepatic and pulmonary injury in liver ischaemia -- reperfusion combined with partial resection
    S Q van Veen
    Department of Surgery Surgical Laboratory, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Br J Surg 93:448-56. 2006
    Lipopolysaccharides mediate inflammation in liver ischaemia-reperfusion (I/R) and partial liver resection (PHX)...
  72. ncbi Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals
    John Quindry
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, P O Box 118206, Gainesville, FL 32611, USA
    Exp Gerontol 40:416-25. 2005
    Endurance exercise provides cardioprotection against ischemia-reperfusion (IR)-induced necrotic cell death in young animals...
  73. doi Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock
    Johanna Catharina Duvigneau
    Department of Biomedical Sciences, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria
    Shock 33:289-98. 2010
    Oxidative stress is believed to accompany reperfusion and to mediate dysfunction of the liver after traumatic-hemorrhagic shock (THS). Recently, endoplasmic reticulum (ER) stress has been suggested as an additional factor...
  74. ncbi Fas ligand expression following normothermic liver ischemia-reperfusion
    Raffaele Cursio
    Laboratoire de Recherches Chirurgicales, IFR 50, Universite de Nice Sophia Antipolis, Nice, France
    J Surg Res 125:30-6. 2005
    The aim of this study was to evaluate the role of the pro-apoptotic molecule Fas Ligand (FasL) in 120 min normothermic ischemia-reperfusion (I-R) induced apoptosis in rat liver treated or not with Z-Asp-cmk caspase inhibitor.
  75. ncbi Effects of genetic deletion of angiotensin-(1-7) receptor Mas on cardiac function during ischemia/reperfusion in the isolated perfused mouse heart
    Carlos H Castro
    Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Life Sci 80:264-8. 2006
    In this study we investigated the role of Mas on cardiac function during ischemia/reperfusion in isolated perfused mouse heart. Following a stabilization period of 30 min, hearts from WT and Mas KO mice were subjected to global ischemia...
  76. pmc Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly
    A R Green
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Pharmacol 153:S325-38. 2008
    ..desmoteplase) has just been reported to have failed in a Phase IIb/III trial, but other thrombolytics and reperfusion agents remain in development...
  77. doi Oxidative stress after thrombolysis-induced reperfusion in human stroke
    Carmen Dominguez
    Biochemistry and Molecular Biology Research Center, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Stroke 41:653-60. 2010
    Animal models of transient ischemia suggest that oxygen-derived free radicals produced on reperfusion of ischemic brain could constitute the main cause of reperfusion injury...
  78. ncbi Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion
    Aneesh B Singhal
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    J Cereb Blood Flow Metab 22:861-8. 2002
    ..However, increased oxygenation theoretically may increase oxygen free-radical injury, particularly during reperfusion. In the present study, the authors assessed the benefit and risks of hyperoxia during focal cerebral ischemia ..
  79. ncbi Role of the permeability transition pore in cytochrome C release from mitochondria during ischemia-reperfusion in rat liver
    Didier Morin
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue du General Sarrail, F 94010 Creteil, France
    Biochem Pharmacol 68:2065-73. 2004
    Ischemia and reperfusion cause mitochondrial dysfunctions that initiate the mitochondrial apoptosis pathway...
  80. ncbi Hypothermic protection in rat focal ischemia models: strain differences and relevance to "reperfusion injury"
    Yubo Ren
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cereb Blood Flow Metab 24:42-53. 2004
    ..same intervention was strikingly effective in the Long-Evans rat even when initiated after as long as 30-minute reperfusion after a 3-hour occlusion...
  81. pmc Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo
    Yuta Abe
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Free Radic Biol Med 46:1-7. 2009
    The mouse model of liver ischemia and reperfusion injury has proven to be valuable for our understanding of the role that reactive oxygen and nitrogen metabolites play in postischemic tissue injury...
  82. ncbi The role of autophagy during ischemia/reperfusion
    Junichi Sadoshima
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Autophagy 4:402-3. 2008
    Ischemia (hypoxia)/reperfusion (I/R) primarily caused by atherosclerosis and thrombosis, induces tissue injury and organ malfunction, and is therefore, an important clinical problem...
  83. ncbi Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Free Radic Biol Med 37:902-11. 2004
    Impaired microvascular function during myocardial ischemia and reperfusion is associated with recruitment of polymorphonuclear neutrophils (PMN) and has been attributed to decreased bioavailability of nitric oxide (NO)...
  84. ncbi HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation
    Osama N El-Assal
    Department of Pediatric Surgery, Children s Hospital, Columbus, 43205, USA
    Gastroenterology 129:609-25. 2005
    ..growth factor-like growth factor (HB-EGF) is a potent chemotactic factor that is induced during ischemia/reperfusion in vivo and intestinal wounding in vitro...
  85. doi Technique for prolonged normothermic ex vivo lung perfusion
    Marcelo Cypel
    Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 27:1319-25. 2008
    ..The aim of this study was to develop a technique of extended (12-hour) ex vivo lung perfusion (EVLP) at normothermia for assessment and protective maintenance of the donor lung...
  86. ncbi Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats
    R A Knight
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich 48202, USA
    Stroke 29:144-51. 1998
    ..As a means of predicting HT, we investigated the role of contrast-enhanced MRI at acute time points in a rat middle cerebral artery occlusion model with reperfusion.
  87. pmc Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model
    Ming Ren
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Proc Natl Acad Sci U S A 100:6210-5. 2003
    ..Moreover, the heat shock response is likely to be involved in lithium's neuroprotective actions. Additionally, our studies indicate that lithium may have clinical utility for the treatment of patients with acute stroke...
  88. ncbi Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia
    Hahn Young Kim
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Charlestown, USA
    Ann Neurol 57:571-5. 2005
    ..Any method that can extend the reperfusion time window would be important...
  89. ncbi Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation
    Brian J D'Cruz
    Department of Emergency Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 22:843-51. 2002
    ..After 12 or 24 hours, neurotrophin levels in hippocampus were measured by immunoblotting. Ischemia and reperfusion increased hippocampal levels of BDNF...
  90. doi Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET)
    Deidre A De Silva
    Division of Neurosciences, Royal Melbourne Hospital, Grattan Street, Parkville 3050, Victoria, Australia
    Stroke 40:2872-4. 2009
    b>Reperfusion and recanalization have both been used as surrogate markers of clinical outcome in trials of stroke thrombolysis...
  91. pmc Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis?
    Turgay Dalkara
    Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    J Cereb Blood Flow Metab 32:2091-9. 2012
    Substantial experimental data and recent clinical evidence suggesting that tissue reperfusion is a better predictor of outcome after thrombolysis than recanalization necessitate that patency of microcirculation after recanalization ..
  92. doi Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels
    Alkesh Jani
    Denver Veterans Affairs Medical Center and Division of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, CO 80262, USA
    Transplantation 92:1215-21. 2011
    ..the 13-lined ground squirrel (GS) cycles through repeated CI during torpor, followed by warm ischemia/reperfusion (WI) during interbout arousal (IBA)...
  93. ncbi Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury
    Guo Chang Fan
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0575, USA
    Circulation 111:1792-9. 2005
    ..We recently reported that increased expression of Hsp20 in cardiomyocytes was associated with improved contraction and protection against beta-agonist-induced apoptosis...
  94. ncbi Thrombolysis-related hemorrhagic infarction: a marker of early reperfusion, reduced infarct size, and improved outcome in patients with proximal middle cerebral artery occlusion
    Carlos A Molina
    Cerebrovascular Unit, Department of Neurology, Hospital Vall d Hebron, Barcelona, Spain
    Stroke 33:1551-6. 2002
  95. doi Regional and temporal changes in proteomic profile after middle cerebral artery occlusion with or without reperfusion in rats
    Hiroshi Yao
    Center for Emotional and Behavioral Disorders, Hizen psychiatric Center, Yoshinogari, Kanzaki, Saga, Japan
    Neurochem Res 34:1999-2007. 2009
    ..6, 12, and 24 h after photothrombotic middle cerebral artery (MCA) occlusion with or without YAG laser-induced reperfusion in adult male spontaneously hypertensive rats...
  96. ncbi Attenuation of ischemia/reperfusion induced MAP kinases by N-acetyl cysteine, sodium nitroprusside and phosphoramidon
    A Mehta
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Cell Biochem 240:19-29. 2002
    Ischemia followed by reperfusion has a number of clinically significant consequences. A number of pathophysiological processes appear to be involved in ischemia/reperfusion (I/R) injury...
  97. doi Correlation between the liver temperature employed during machine perfusion and reperfusion damage: role of Ca2+
    Mariapia Vairetti
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Liver Transpl 14:494-503. 2008
    ..The reperfusion period (2 hours at 37 degrees C) was performed under the same conditions used for MP-preserved and cold storage-..
  98. ncbi On-line microdialysis-graphite furnace atomic absorption spectrometry in the determination of brain magnesium levels in gerbils subjected to cerebral ischemia/reperfusion
    Ming Cheng Lin
    Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
    J Am Coll Nutr 23:561S-565S. 2004
  99. doi Reperfusion therapies for acute ischemic stroke: current pharmacological and mechanical approaches
    Carlos A Molina
    Neurovascular Unit, Department of Neuroscience, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 42:S16-9. 2011
    Arterial recanalization and subsequent reperfusion have extensively demonstrated their ability to restore the brain function when performed shortly after acute ischemic stroke...
  100. doi Ischemic post-conditioning protects brain and reduces inflammation in a rat model of focal cerebral ischemia/reperfusion
    Bianzhi Xing
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 105:1737-45. 2008
    ..Post-cond) is a phenomenon in which intermittent interruptions of blood flow in the early phase of reperfusion can protect organ from ischemia/reperfusion (I/R) injury...
  101. ncbi Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalization
    Rishi Gupta
    Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pennsylvania, USA
    Stroke 37:986-90. 2006
    ..Endovascular therapies using mechanical and pharmacological modalities for large vessel occlusions in acute stroke are rapidly evolving. Our aim was to determine whether one modality is associated with higher recanalization rates...

Research Grants83

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..applicant): Abstract (All changes from the previous submission are marked by line in the margins) Ischemia and reperfusion (I/R) injury results from an acute increase in oxidative/inflammatory stress during reperfusion after ischemia ..
  2. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..RTX) is developing a novel bifunctional small molecule, R-503, intended for the prevention of lung ischemia-reperfusion injury (LIRI) associated with orthotopic lung transplantation...
  3. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..the effects of aging and estrogen (E2) deficiency are additive with regard to ethanol-induced cardiac ischemia/reperfusion (I/R) injury...
  4. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Methods. Experiments will be conducted in anesthetized mice subjected to acute myocardial ischemia-reperfusion induced by reversible coronary ligation, and in cultured cardiomyocytes subjected to oxygen and glucose ..
  5. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
    Gary Cecchini; Fiscal Year: 2013
    ..of cells, studies will be undertaken to investigate how acetylation affects the response in a cardiac ischemia/reperfusion injury model...
  7. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..maintenance of or improvement in islet function and to define the effect of aMSC third party MSC on ischemia reperfusion injury. Aim 3...
  8. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..In support of this approach, in a rodent model of renal ischemia/reperfusion injury R- 801 profoundly reduced the elevation in BUN and creatinine, blocked neutrophil inflammation, and ..
  9. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..based anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
  10. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..or deficient and both of these have been implicated in bacterial, viral and parasitic infections, ischemia-reperfusion injury, inflammatory bowel disease, celiac disease and colorectal cancer...
  11. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..ABSTRACT Interruption and subsequent restoration of circulation in tissues causes varying amounts of ischemia- reperfusion injury (IRI)...
  12. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..Oxidant stress has been implicated in the cellular dysfunction associated with ischemia- reperfusion injury, vascular disease, stroke, diabetes, neurodegenerative diseases, liver disease, renal disease, ..
  13. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..the isoform-specific functions of GSK-3 during pressure overload-induced cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on novel ..
  14. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..mediators, neuroprotectin D1 (NPD1) and aspirin-triggered (AT)-neuroprotectin D1 (AT-NPD1), inhibit ischemia-reperfusion mediated leukocyte infiltration and pro-inflammatory gene expression, as well as elicit neuroprotection in the ..
  15. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..proteins is a reversible process dependent on oxygen concentration hence the hypoxic environment or ischemia/reperfusion of the preeclamptic placenta may cause protein nitration and altered cellular respiration and placental ..
  16. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Radikal Therapeutics (RTX) is developing a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX)...
  17. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..Reactive oxygen species (ROS) are released acutely in large amounts during ischemia or ischemia/reperfusion injury...
  18. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..SDF1 is under active investigation as a treatment for prevention of myocardial ischemia/reperfusion injury...
  19. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Ischemia-reperfusion (I/R) injury by way of heart attacks, strokes and diabetes is one of the major causes of morbidity and mortality in the United States...
  20. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..apoptosis contributes to adverse ventricular remodeling after myocardial infarction and myocardial ischemia-reperfusion injury...
  21. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012 vivo by RNAi injection with uptake specifically by the proximal tubule will be performed along with Ischemia/Reperfusion (I/R) to simulate the de-differentiation and re-differentiation process...
  22. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..ER) expression in the aged heart leads to a vicious cycle of increased oxidative stress (ROS) and ischemia/reperfusion (I/R injury), while selective engagement of non-genomic ER pathways can rescue this phenotype...
  23. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Title of grant: Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Ischemia-reperfusion (I/R) injury to vital organs and tissue can occur in a variety of clinical ..
  24. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..g., reperfusion, wound healing, diabetes) that are affected by NO and translation inhibition...
  25. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..etiology of intestinal cell necrosis is uncertain, risk factors include anisotonic fluids, toxins, ischemia- reperfusion injury and reactive oxygen species...
    John J Lemasters; Fiscal Year: 2012
    ..activation of the HIF-1/prolyl hydroxylase oxygen-sensing signal cascade blocks the MPT and minimizes storage/reperfusion injury to liver grafts...
  27. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..In support of our hypothesis, D609 (a) significantly reduced cerebral infarction at reperfusion days 1 and 3, (b) up-regulated p21 and p27 through ceramide accumulation, and (c) attenuated Rb phosphorylation ..
  28. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013 turn, increases the susceptibility of SCD+asthma mice to pulmonary vaso-occlusion when subjected to hypoxia/reperfusion (H/R) injury. To test these hypotheses we propose 3 aims...
  29. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..various model of inflammation including, streptomycin induced diabetes, LPS induced septic shock, ischemia and reperfusion injury...
  30. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..species, which we showed to be responsible for mannose binding lectin (MBL) ligand expression in ischemia/reperfusion (I/R) models...
  31. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..experiment in which we will demonstrate that PH is neuroprotective in a mouse model of focal cerebral ischemia/reperfusion. Multiple physiologic variables (such as core temperature, blood pressure, and heart rate) will be collected by ..
  32. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..After bypass, reperfusion occurs and induces ischemia reperfusion injury...
  33. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    Ischemia-reperfusion (IRP) injury is an important clinical problem, which determines morbidity and mortality after liver transplantation, liver surgery and hemorrhagic or septic shock...
  34. Novel Diagnostics to Detect Lung Injury
    Elizabeth R Jacobs; Fiscal Year: 2013
    ..Ischemia-reperfusion (IR) lung damage is also encountered clinically in conditions beyond lung transplantation, including ..
  35. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..or towards compromised tissues after an ischemic attack (a deleterious effect), such as in the case of ischemia/reperfusion injury (I/RI) in the heart...
  36. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    Sponsor Abstract Lung ischemia reperfusion injury (LIRI) develops in 15-25% of lung transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased ..
  37. Mitochondrial Mechanisms of Programmed Necrosis in the Aged Female Heart
    Alexandra M Machikas; Fiscal Year: 2013
    ..Ischemia- reperfusion (I/R) injury and associated cell death increases with age;however, the predominant cell death type associated ..
  38. Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    HUA LINDA CAI; Fiscal Year: 2013
    ..critical signaling role of cardiac microvascular endothelium in mediating cardioprotection during ischemia reperfusion (I/R) injury of the heart...
  39. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..reactivity, lung epithelial pathology, vascular smooth muscle biology, gene expression and lipids, ischemia-reperfusion, reactive oxygen radicals, cell signaling pathways, vascular remodeling, and angiogenesis, to name a few...
  40. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..but also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  41. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..production of reactive oxygen species, which we showed to be responsible for MBL ligand expression in ischemia/reperfusion models...
  42. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..S1P was sufficient to decrease infarction and enhance contractility in mouse hearts subjected to ischemia-reperfusion. We developed a rapid and accurate radioassay for measurement of sphingosine kinase activity and established an ..
  43. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..Induction of HO-1 is an adaptive and protective response in acute kidney injury following ischemia-reperfusion, nephrotoxins, transplantation, acute glomerulonephritis and rhabdomyolysis as well as several non-renal ..
  44. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Reperfusion after an ischemic stroke event is known to produce ROS that can cause neurovascular injury, BBB disruption with secondary vasogenic edema, and hemorrhagic transformation of infarcted ..
  45. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    ..of this Program Project is to define the mechanisms of inflammation and repair in the heart after ischemia and reperfusion. The Projects focus on transcription factors and radical messenger molecules that mediate the response to ..
    Sung Wan Kim; Fiscal Year: 2012
    ..At the present time, there is no clinically reliable means to prevent ischemia/reperfusion injury to the myocardium...
  47. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ..more importantly, a single dose of aTRA (1 mg/kg, 6h pretreatment) completely protects mice from renal ischemia/reperfusion (I/R) injury...
  48. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    ..Currently, the vascular disease process involving hypoxia, free heme and ischemia reperfusion in SCD are not well understood...
  49. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..hypertension, or kidneys subjected to prolonged cold ischemia and exhibiting increased ischemia-normothermic reperfusion injury and delayed graft function, therefore necessitating dialysis in the recipient...
  50. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..While the exact mechanisms of ischemia/reperfusion injury remain unclear, inhibition of complement activation (e.g...
  51. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..including tissue plasminogen activator, aspirin, clopidogrel and heparin, still induces inadequate coronary reperfusion in 30-40% of patients and early thrombotic reocclusion in 5-10% patients...
  52. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..Ischemia-reperfusion injury associated with these conditions can lead to permanent tissue damage or neurologic deficits...
  53. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..The studies will include novel methods to monitor reperfusion non-invasively by microultrasound during the first two weeks post-grafting, and molecular and cellular ..
  54. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute limb ischemia reperfusion injury (LIRI) is characterized by an imbalance in the free radicals nitric oxide and superoxide anion...
  55. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    ..We will study hepatic lesions, mt-dysfunction, myocardial ischemia/reperfusion injury in alcohol-treated or alcohol + LPS treated rats...
  56. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..Following ischemia-reperfusion (IR)- and cisplatin-induced AKI, meprin A is redistributed throughout the cytoplasm and extracellularly ..
  57. Protein Kinase C in the Repair of Cellular Functions
    Grazyna Nowak; Fiscal Year: 2013
    ..involved in: 1) the loss of renal functions associated with acute renal failure (ARF) as caused by ischemia/reperfusion and 2) the repair of renal functions following ARF...
  58. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ..In rats subjected to renal ischemia/reperfusion injury (RIRI), IV administration of R-100 prior to reperfusion reduced the 6 h elevations in serum creatinine, ..
  59. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..These physiological actions are ideal for the treatment of myocardial ischemia-reperfusion (MI-R) injury...
  60. Role of The Jak-Stat Pathway in Ischemic Preconditioning
    Yu Ting Xuan; Fiscal Year: 2010
    ..Although apoptosis has been shown to play a crucial role in cell death after ischemia/reperfusion injury, it remains largely unknown whether late PC protects against cardiac apoptosis and what signaling/..
  61. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..occurring IgM anti-leucocyte autoantibodies in inhibiting inflammatory processes that occur after ischemia-reperfusion injury (IRI)...
  62. Contractile Regulation of Cardiocyte Protein Synthesis
    Paul J McDermott; Fiscal Year: 2013
    ..deprivation and the adverse effects produced in cardiomyocytes during reoxygenation of the myocardium (ischemia/reperfusion)...
  63. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..that can reduce acute tissue injury, chronic pathological remodeling, and mortality caused by ischemia and reperfusion. Thus, prevention of these consequences of myocardial infarction have direct bearing on the health of both the ..
  64. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..provided by applicant): Project Summary/Abstract: Liver injury induced by hepatic ischemia followed by reperfusion is a major pathogenic cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic ..
    GREGORY STAHL; Fiscal Year: 2007
    While the exact mechanisms of ischemia/reperfusion injury remain to be elucidated, inhibition of complement activation (e.g., sCR1 or C 1 esterase inhibitor), depletion of complement components (e.g...
    CHARLES COLLARD; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract) Ischemia-reperfusion injury leads to the activation and deposition of serum complement on the vascular endothelium...
  67. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury...
  68. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John K Buolamwini; Fiscal Year: 2010
    ..5 billion per year. Ischemia-reperfusion injury is the major cause of complications of cardiac surgery;morbidity and mortality, but current ..
    AUBREY TAYLOR; Fiscal Year: 1992
    Tissue injury due to ischemia and reperfusion occurs in common clinical disorders such as myocardial infarction, acute renal failure, stroke, and ischemic bowel syndromes...
    John Murray; Fiscal Year: 1993
    ..Although early reperfusion by either pharmacologic or mechanical means has been conclusively shown to reduce cardiac mortality, less ..
    Michael Hess; Fiscal Year: 1990
    ..the generation of cytotoxic oxygen free radicals occupies an important role in the pathophysiology of ischemic/reperfusion injury...
    Pak Chan; Fiscal Year: 2007
    Oxidative stress generated during cerebral ischemia and reperfusion is a critical event leading to damage of the neurovascular unit that causes blood-brain barrier disruption, with secondary vasogenic edema and hemorrhagic ..
  73. Prevention of ischemia reperfusion injury associated with acute myocardial infarc
    Craig Sherman; Fiscal Year: 2010
    ..Injection and owns patent rights to a recently discovered use for sodium nitrite as a means to prevent ischemia-reperfusion injury...
    MERVYN FORMAN; Fiscal Year: 1991
    Myocardial infarction remains a major cause of morbidity and mortality in the United States. Early reperfusion has been shown to reduce infarct size, improve ventricular function, and decrease mortality in the animal model and in man...
  75. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..research initiative is to delineate the cytoprotective role of proinflammatory cytokines in myocardial ischemia reperfusion (I/R) injury...
    RONALD KORTHUIS; Fiscal Year: 2003
    ..of skeletal muscle and other tissues to deleterious effects of a more prolonged exposure to ischemia and reperfusion (IR) 24 hours later, a phenomenon referred to as delayed or late phase ischemic preconditioning (delayed IPC)...
  77. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    Conditions associated with ischemia/reperfusion injury (IRI) such as myocardial infarction and acute ischemic renal failure are among the major causes of morbidity and mortality...
  78. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..This paradoxical phenomenon, broadly termed ischemia/reperfusion injury, is manifested more severely in the elderly...
  79. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..A key goal of preconditioning is to reduce the damage inflicted by ischemia-reperfusion injury (IRI) that occurs when the ischemic/ hypoxic organ is connected to the recipient's circulation...
    EDWARD LESNEFSKY JR; Fiscal Year: 1999 isolated, buffer perfused hearts obtained from elderly 24 month Fischer 344 rats following ischemia and reperfusion compared to hearts from 6 month Fischer adults, supporting a myocardial source of the increased damage...
    James Loyd; Fiscal Year: 1992
    This project will examine the mechanisms of lung ischemia/reperfusion (I/R) injury with the ultimate goal to discover therapy for I/R an important clinical problem...
    Peter Safar; Fiscal Year: 1990
    ..We hypothesize that post-CA, inadequate cerebral reperfusion and prolonged global hypoperfusion are key factors in permanent brain damage; that blood brain barrier leakage ..
    Nicholas Vedder; Fiscal Year: 2000
    ..the mechanisms of endothelial activation leading to neutrophil (PMN) adherence in the setting of ischemia-reperfusion, focusing on the role of protein kinase C (PKC) in regulating endothelial P-selectin (CD62P) mobilization and ..