physical stimulation


Top Publications

  1. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006
  2. pmc Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
    H Henrik Ehrsson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:10564-73. 2005
  3. ncbi Central cancellation of self-produced tickle sensation
    S J Blakemore
    Wellcome Department of Cognitive Neurology, London, UK
    Nat Neurosci 1:635-40. 1998
  4. ncbi Neural substrates of tactile imagery: a functional MRI study
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroreport 14:581-5. 2003
  5. ncbi Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus
    Tamar R Makin
    Neurobiology Department, Life Sciences Institute, Hebrew University, Jerusalem 91904, Israel
    J Neurosci 27:731-40. 2007
  6. ncbi Thermosensory activation of insular cortex
    A D Craig
    Division of Neurosurgery, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, Arizona 85013, USA
    Nat Neurosci 3:184-90. 2000
  7. pmc TRPA1 modulates mechanotransduction in cutaneous sensory neurons
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:4808-19. 2009
  8. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
  9. ncbi A multisensory investigation of the functional significance of the "pain matrix"
    Andre Mouraux
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 54:2237-49. 2011
  10. ncbi Unsupervised whisker tracking in unrestrained behaving animals
    Jakob Voigts
    Undergraduate Program in Mathematics, University of Heidelberg, Heidelberg, Germany
    J Neurophysiol 100:504-15. 2008

Research Grants

Detail Information

Publications302 found, 100 shown here

  1. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006
    ..TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons...
  2. pmc Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
    H Henrik Ehrsson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:10564-73. 2005
    ..We propose that this could be the mechanism for the feeling of body ownership...
  3. ncbi Central cancellation of self-produced tickle sensation
    S J Blakemore
    Wellcome Department of Cognitive Neurology, London, UK
    Nat Neurosci 1:635-40. 1998
    ..This difference suggests that the cerebellum is involved in predicting the specific sensory consequences of movements, providing the signal that is used to cancel the sensory response to self-generated stimulation...
  4. ncbi Neural substrates of tactile imagery: a functional MRI study
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroreport 14:581-5. 2003
    ..Our results suggest that the primary and secondary somatosensory areas are recruited during tactile imagery, and have partially overlapping neural substrates for the perception of tactile stimulation...
  5. ncbi Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus
    Tamar R Makin
    Neurobiology Department, Life Sciences Institute, Hebrew University, Jerusalem 91904, Israel
    J Neurosci 27:731-40. 2007
    ..We therefore suggest that, whereas cortical regions within the posterior IPS and LOC represent hand-centered space in a predominantly visual manner, the anterior IPS uses multisensory information in representing perihand space...
  6. ncbi Thermosensory activation of insular cortex
    A D Craig
    Division of Neurosurgery, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, Arizona 85013, USA
    Nat Neurosci 3:184-90. 2000
    ..Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices...
  7. pmc TRPA1 modulates mechanotransduction in cutaneous sensory neurons
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:4808-19. 2009
  8. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
    ..Analysis of signals in tactile afferent neurons and central processes in humans reveals how contact events are encoded and used to monitor and update task performance...
  9. ncbi A multisensory investigation of the functional significance of the "pain matrix"
    Andre Mouraux
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 54:2237-49. 2011
    ..Taken together, these findings suggest that the largest part of the fMRI responses elicited by phasic nociceptive stimuli reflects non nociceptive-specific cognitive processes...
  10. ncbi Unsupervised whisker tracking in unrestrained behaving animals
    Jakob Voigts
    Undergraduate Program in Mathematics, University of Heidelberg, Heidelberg, Germany
    J Neurophysiol 100:504-15. 2008
    ..e., speed, amplitude and duration) of whisker touch and finally show that whisker deprivation does not alter whisking kinematics during haptic exploration...
  11. ncbi Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
  12. pmc Upper limb amputees can be induced to experience a rubber hand as their own
    H Henrik Ehrsson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 131:3443-52. 2008
  13. ncbi Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
    Chao Ma
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 89:1588-602. 2003
  14. ncbi Individual differences in pain sensitivity: genetic and environmental contributions
    Christopher S Nielsen
    Division of Mental Health, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Pain 136:21-9. 2008
    ..It also indicates that differences in pain scale usage account for a minor portion of the variance, providing strong support for the validity of subjective pain ratings as measures of experienced pain...
  15. ncbi Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, SE 221 84 Lund, Sweden
    J Neurosci 23:9620-31. 2003
    ..The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs...
  16. ncbi Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    J Biomech 40:1333-9. 2007
    ..Ideally, such mechanical signals represent a non-pharmacologic means of controlling bone mass and morphology in spite of systemic pressures for bone resorption...
  17. pmc The mechanical variables underlying object localization along the axis of the whisker
    Lorenz Pammer
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 33:6726-41. 2013
    ..More generally, our data imply that mice can measure the amplitudes of forces in the sensory follicles for tactile sensation...
  18. ncbi Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
    Christian Sprenger
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Pain 152:428-39. 2011
    ..Functional magnetic resonance imaging shows how the human brain is involved in heterotopic noxious conditioning and reveals active supraspinal pain modulatory mechanisms during dual pain stimulation...
  19. pmc A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02215, USA
    J Neurosci 28:13354-62. 2008
    ..In conclusion, we found evidence that nocebo hyperalgesia may be predominantly produced through an affective-cognitive pain pathway (medial pain system), and the left hippocampus may play an important role in this process...
  20. pmc Neuronal basis for object location in the vibrissa scanning sensorimotor system
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:455-68. 2011
    ..Efferent signals in motor cortex report the range of the scan. Collectively, these signals allow the rodent to form a percept of object location...
  21. ncbi Individual sensitivity to pain expectancy is related to differential activation of the hippocampus and amygdala
    Michal Ziv
    Department of Psychology, University of Haifa, Mount Carmel, Haifa, Israel
    Hum Brain Mapp 31:326-38. 2010
    ..Our findings suggest that the amygdala supports an innate tendency to approach or avoid pain as reflected in HA trait, whereas the hippocampus mediates the effect of context possibly via appraisal of the stimulus value...
  22. pmc Fake hands in action: embodiment and control of supernumerary limbs
    Roger Newport
    School of Psychology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    Exp Brain Res 204:385-95. 2010
    ..Thus, it would appear that fake limbs can be incorporated into the body schema as well as the body image, but while multiple limbs can be incorporated into the body image, the body schema can accommodate only one...
  23. ncbi Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
    T Philip Malan
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85724 5114, USA
    Anesthesiology 96:1161-7. 2002
    ..This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury...
  24. pmc Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex
    Michael Brecht
    Department of Cell Physiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    J Physiol 553:243-65. 2003
    ..We conclude that the lemniscal (barrel-related) and paralemniscal (septum-related) afferent inputs remain anatomically and functionally segregated in L2/3...
  25. ncbi Encoding of whisker vibration by rat barrel cortex neurons: implications for texture discrimination
    Ehsan Arabzadeh
    Cognitive Neuroscience Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 23:9146-54. 2003
    ..We conclude that vibration kinetics are rapidly and reliably encoded in the firing rate of cortical ensembles. Therefore, the cortical representation of vibration speed could underlie texture discrimination...
  26. ncbi Activity-dependent development of tactile and nociceptive spinal cord circuits
    Stephanie C Koch
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
    Ann N Y Acad Sci 1279:97-102. 2013
  27. pmc Cortical excitation and inhibition following focal traumatic brain injury
    Ming chieh Ding
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 31:14085-94. 2011
  28. pmc Millisecond precision spike timing shapes tactile perception
    Emily L Mackevicius
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 32:15309-17. 2012
    ..In light of these results, the peripheral representation of complex skin vibrations draws a powerful analogy with the auditory and vibrissal systems...
  29. pmc A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
    Wendy M Knowlton
    Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 33:2837-48. 2013
    ..Together, these data show that, although some limited cold sensitivity remains in Trpm8(-/-) mice, TRPM8 neurons are required for the breadth of behavioral responses evoked by cold temperatures...
  30. ncbi Fronto-parietal areas necessary for a multisensory representation of peripersonal space in humans: an rTMS study
    Andrea Serino
    Universita degli Studi di Bologna, Bologna, Italy
    J Cogn Neurosci 23:2956-67. 2011
    ..These findings indicate that multisensory interaction around the hand depends on the functions of vPMc and PPc, thus pointing to the necessity of this human fronto-parietal network in multisensory representation of PPS...
  31. pmc Excitability of Aβ sensory neurons is altered in an animal model of peripheral neuropathy
    Yong Fang Zhu
    Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St West, HSC 3N5C, Hamilton, Ontario, Canada
    BMC Neurosci 13:15. 2012
    ..Thus, the present study aimed at recording intracellularly from Aβ-fiber dorsal root ganglion (DRG) neurons and determining excitability of the peripheral receptive field, of the cell body and of the dorsal roots...
  32. ncbi Observing touch activates human primary somatosensory cortex
    Elina Pihko
    Brain Research Unit, Low Temperature Laboratory, Aalto University School of Science and Technology, 00076 Aalto, Espoo, Finland
    Eur J Neurosci 31:1836-43. 2010
    ..The results suggest that when people observe somebody else being touched, activation of their own somatosensory circuitry may contribute to understanding of the other person's somatosensory experience...
  33. ncbi Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction
    Toru Taguchi
    Department of Neural Regulation, Division of Regulation of Organ Function, Research Institute of Environmental Medicine, Nagoya, Japan
    J Neurophysiol 94:2822-31. 2005
    ..These results suggest that augmentation of the mechanical response in muscle thin-fiber sensory receptors might be related to the muscle tenderness in DOMS after ECC...
  34. ncbi Absence of rapid sensory adaptation in neocortex during information processing states
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuron 41:455-64. 2004
    ..The primary sensory thalamocortical pathway of alert and expectant animals is in the adapted state, which may be required for adequate sensory information processing...
  35. ncbi Behavioural and histological observations of sensory impairment caused by tight ligation of the trigeminal nerve in mice
    Hiroyuki Seino
    Division of Dental Anaesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Neurosci Methods 181:67-72. 2009
    ..Therefore, we suggest that our experimental mouse model could represent a new model for clarifying the mechanism of the sensory impairment caused by peripheral nerve injury...
  36. pmc Functional MRI of working memory and selective attention in vibrotactile frequency discrimination
    Peter Soros
    Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    BMC Neurosci 8:48. 2007
    ..To investigate selective attention, a distractor stimulus was occasionally presented contralaterally, simultaneous to the probe...
  37. ncbi The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation
    Thomas Klein
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 139:507-19. 2008
    ..Because none of the changes in sensory parameters was unique for the site of conditioning stimulation, these data suggest that heterosynaptic interactions are the predominant mechanism of LTP in nociceptive pathways...
  38. ncbi Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates
    Christopher A Brown
    Human Pain Research Group, Clinical Sciences Building, Hope Hospital, Salford M6 8HD, United Kingdom
    Pain 135:240-50. 2008
    ..This suggests that biasing of pain reports and LEPs by expectation involves temporally precise activity in specific cortical networks...
  39. ncbi Sensory stimulus evokes inhibition rather than excitation in cerebellar Purkinje cells in vivo in mice
    Chun Ping Chu
    College of Basic Medicine, Yanbian University, Yanji City, Jilin Province, China
    Neurosci Lett 487:182-6. 2011
  40. pmc Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
    Steve Davidson
    University of Minnesota, Minneapolis, USA
    Nat Neurosci 12:544-6. 2009
  41. ncbi Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study
    Christian Geber
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
    Pain 152:548-56. 2011
  42. pmc VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch
    Malin C Lagerström
    Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden
    Neuron 68:529-42. 2010
    ..This study establishes that VGLUT2 is a major player in TRPV1 thermal nociception and also serves to regulate a normal itch response...
  43. pmc Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex
    J Berwick
    Department of Psychology, University of Sheffield, Sheffield S10 2TN, UK
    J Neurophysiol 99:787-98. 2008
    ..These data confirm hemodynamics are capable of providing accurate "single-condition" maps of neural activity...
  44. ncbi Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain
    Ulrike Friebel
    Functional Imaging Unit, Center for Diagnostic Radiology, University of Greifswald, Germany
    Neuroimage 58:1070-80. 2011
    ..Activation clusters in the anterior cingulate cortex and caudal anterior insula suggest a strong emotional contribution to the processing of chronic neuropathic pain...
  45. ncbi Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients
    G Sandrini
    University Centre for Adaptive Disorders and Headache, IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
    Cephalalgia 26:782-9. 2006
    ..Impairment of endogenous supraspinal pain modulation systems may contribute to the development and/or maintenance of central sensitization in primary headaches...
  46. ncbi Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation
    Elena Peltz
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany
    Neuroimage 54:1324-35. 2011
  47. ncbi The whole body receptive field of dorsal horn multireceptive neurones
    Daniel Le Bars
    INSERM, 2, rue d Alesia, 75014, Paris, France
    Brain Res Brain Res Rev 40:29-44. 2002
  48. ncbi A Drosophila mechanosensory transduction channel
    R G Walker
    Department of Biology, Howard Hughes Medical Institute, University of California, San Diego, CA 92093 0649, USA
    Science 287:2229-34. 2000
    ..nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs...
  49. ncbi Evoked potentials generated by noxious stimulation in the human infant brain
    Rebeccah Slater
    Neuroscience, Physiology and Pharmacology, University College London, United Kingdom
    Eur J Pain 14:321-6. 2010
    ..These results provide the first direct evidence of specific noxious-evoked neural activity in the infant brain and suggest that newborn infants are capable of the sensory-discriminative aspects of pain experience...
  50. ncbi Visual-vestibular interactive responses in the macaque ventral intraparietal area (VIP)
    Frank Bremmer
    Laboratoire de Physiologie de la Perception et de l Action, CNRS College de France, 11 place Marcelin Berthelot, F 75231 Paris Cedex 05, France
    Eur J Neurosci 16:1569-86. 2002
    ..These results, taken together with data on responses to optic flow stimuli obtained in a parallel study, strongly suggest an involvement of area VIP in the analysis and the encoding of self-motion...
  51. pmc A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS
    Zhuhao Wu
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, MD 21205, USA
    Neuron 70:281-98. 2011
    ..These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly...
  52. ncbi Effects of different viewing perspectives on somatosensory activations during observation of touch
    Michael Schaefer
    Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Hum Brain Mapp 30:2722-30. 2009
    ..Moreover, somatosensory responses differed depending on the perspective of the observed touch. We discuss the results in terms of a possible mirror neuron system for observed and experienced touch...
  53. ncbi An elegant mind: learning and memory in Caenorhabditis elegans
    Evan L Ardiel
    Brain Research Centre and Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Learn Mem 17:191-201. 2010
    ..Several genes have been identified with no known role other than mediating behavior plasticity...
  54. ncbi Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
    X Chen
    Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center (UCSF, University of California, San Francisco 94143-0440, USA
    Neuroscience 102:185-92. 2001
    ..The present findings suggest that study of individual neurons in vitro may allow elucidation of the ionic basis of enhanced nociception in diabetic neuropathy...
  55. ncbi Encoding of direction of fingertip forces by human tactile afferents
    I Birznieks
    Department of Integrative Medical Biology, Physiology Section, Umea University, SE 901 87 Umea, Sweden
    J Neurosci 21:8222-37. 2001
    ..We conclude that tactile afferents from the whole terminal phalanx potentially contribute to the encoding of direction of fingertip forces similar to those that occur when subjects manipulate objects under natural conditions...
  56. ncbi The influence of stimulus cue on the initiation of stepping in young and older adults
    M W Rogers
    Department of Physical Therapy and Human Movement Sciences, Northwestern University Medical School, Chicago, IL, USA
    Arch Phys Med Rehabil 82:619-24. 2001
    ..The abilities of many older persons may be compromised in situations where rapid adjustments in the base of support through stepping are triggered by environmental stimuli...
  57. ncbi Synthesis of multiwhisker-receptive fields in subcortical stations of the vibrissa system
    Elena Timofeeva
    Centre de Recherche Universite Laval Robert Giffard, 2601 de la Canardiere, Quebec G1J 2G3, Canada
    J Neurophysiol 91:1510-5. 2004
    ..07 whisker after the lesion. Together these results indicate that the synthesis of surround receptive fields in subcortical stations relies almost exclusively on intersubnuclear projections from the spinal trigeminal complex to the PrV...
  58. ncbi Tickling expectations: neural processing in anticipation of a sensory stimulus
    K Carlsson
    Karolinska Institute Karolinska Hospital, Sweden
    J Cogn Neurosci 12:691-703. 2000
    ..Moreover, this study indicates that activation of primary somatosensory cortex can be obtained without intra-modal sensory input. These findings suggest that anticipation may invoke a tonic top-down regulation of neural activity...
  59. ncbi Warm pleasant feelings in the brain
    Edmund T Rolls
    University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, England, UK
    Neuroimage 41:1504-13. 2008
    ..This conclusion appears to be the case for processing in a number of sensory modalities, and the finding with such prototypical stimuli as warm and cold provides strong support for this principle...
  60. ncbi Realignment of temporal simultaneity between vision and touch
    Kohske Takahashi
    Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Neuroreport 19:319-22. 2008
    ..No intermanual transfer of the adaptation effect was, however, found. These results indicate that the perceptual simultaneity between vision and touch is adaptive, and is determined separately for each hand...
  61. ncbi Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy
    Graham M Pitcher
    Departments of Physiology and Psychiatry, McGill University, 3655 Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Exp Neurol 214:219-28. 2008
    ..Our findings reveal that ectopic afferent activity from multiple regions along peripheral nerves may drive CNS changes and the symptoms of pain associated with peripheral neuropathy...
  62. ncbi Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    B Shim
    Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
    Neuroscience 132:193-201. 2005
    ..This nociceptor sensitization can contribute to neuropathic pain...
  63. pmc Thalamic sensitization transforms localized pain into widespread allodynia
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 68:81-91. 2010
  64. ncbi The role of fingerprints in the coding of tactile information probed with a biomimetic sensor
    J Scheibert
    Laboratoire de Physique Statistique de l Ecole Normale Superieure, CNRS UMR 8550, Associé aux Universités Paris 6 et Paris 7, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Science 323:1503-6. 2009
    ..Thus, fingerprints may perform spectral selection and amplification of tactile information that facilitate its processing by specific mechanoreceptors...
  65. ncbi Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
    G M Khan
    Department of Anesthesiology H187, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Neuroscience 114:291-9. 2002
    ..Our electrophysiological data provide substantial new evidence that the abnormal sensory input from Adelta- and Abeta-fiber afferents may play an important role in diabetic neuropathic pain...
  66. pmc Differential effect of steady versus oscillating flow on bone cells
    C R Jacobs
    Department of Orthopaedics and Rehabilitation, Penn State University, Hershey 17033, USA
    J Biomech 31:969-76. 1998
    ..Thus. these findings support the hypothesis that the response of bone cells to fluid flow is dependent on chemotransport effects...
  67. ncbi Spatio-temporal prediction modulates the perception of self-produced stimuli
    S J Blakemore
    Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    J Cogn Neurosci 11:551-9. 1999
    ..e., its tickliness) is proportional to the error between the sensory feedback predicted by an internal forward model of the motor system and the actual sensory feedback produced by the movement...
  68. ncbi Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain
    Karin B Jensen
    Stockholm Brain Institute, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden
    Pain 144:95-100. 2009
  69. ncbi Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera
    Lars Arendt-Nielsen
    Department of Health Sciences and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Pain 10:556-72. 2009
    ..Assessing pain has become a question of solving a multi-input, multi-output problem, with the solution providing the possibility of teasing out which pain pathways and mechanisms are involved, impaired, or affected...
  70. ncbi Spike timing, spike count, and temporal information for the discrimination of tactile stimuli in the rat ventrobasal complex
    G Foffani
    Neurosignals Group, Hospital Nacional de Paraplejicos, Servicio de Salud de Castilla La Mancha, Toledo 45071, Spain
    J Neurosci 29:5964-73. 2009
    ..We conclude that temporal information conveyed by spike timing can be higher than spike count information for the discrimination of somatosensory stimuli in the rat ventrobasal complex...
  71. pmc Separate peripheral pathways for pruritus in man
    Barbara Namer
    Department of Physiology and Pathophysiology, University of Erlangen Nurnberg, Germany
    J Neurophysiol 100:2062-9. 2008
    ..It is distinct from the pathway for histamine-mediated pruritus and does not involve the histamine-sensitive mechano-insensitive fibers...
  72. ncbi Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice
    Graham W Knott
    Institut de Biologie Cellulaire et Morphologie, Universite de Lausanne, Rue du Bugnon 9, CH 1005, Lausanne, Switzerland
    Neuron 34:265-73. 2002
    ..These results indicate activity-dependent alterations in synaptic circuitry in adulthood, modifying the flow of sensory information into the cerebral cortex...
  73. ncbi Discrimination of vibrotactile stimuli in the rat whisker system: behavior and neurometrics
    Todor V Gerdjikov
    Werner Reichardt Center for Integrative Neuroscience, University of Tubingen, 72076 Tübingen Germany
    Neuron 65:530-40. 2010
    ..In conclusion, we suggest that stimulus mean absolute velocity, encoded in primary afferent spike counts, plays a prominent role for whisker-mediated perception...
  74. ncbi Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
    Valérie Kayser
    University Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    Pain 130:235-48. 2007
    ..These results support the conclusion that the complex control of pain mechanisms by 5-HT, acting at multiple receptors, is physiologically relevant in mice...
  75. ncbi Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome
    Doreen B Pfau
    Department of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    Pain 147:72-83. 2009
    ..g. a disturbance of central pain processing, in this subgroup of TMD patients. Those patients could be identified on the basis of their tender point count as an easy practicable screening tool...
  76. ncbi A common framework for perceptual learning
    Aaron R Seitz
    Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Curr Opin Neurobiol 17:148-53. 2007
  77. ncbi On the other hand: dummy hands and peripersonal space
    Tamar R Makin
    Department of Neurobiology, Life Sciences Institute, Hebrew University, Jerusalem 91904, Israel
    Behav Brain Res 191:1-10. 2008
    ..Finally, we propose a simple model that situates the 'rubber hand illusion' in the neurophysiological framework of multisensory hand-centred representations of space...
  78. ncbi Perceptual correlate of nociceptive long-term potentiation (LTP) in humans shares the time course of early-LTP
    Thomas Klein
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D 55099 Mainz, Germany
    J Neurophysiol 96:3551-5. 2006
    ..3 h. These findings suggest that a single HFS session induces nociceptive LTP in healthy subjects that corresponds to early-LTP (LTP1), implying primarily posttranslational mechanisms for this type of plasticity of human pain perception...
  79. ncbi A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats
    M Chacur
    Laboratory of Pathophysiology, Butantan Institute, Avenue Vital Brazil, 1500, 05503-900 Sao Paulo, SP, Brazil
    Pain 94:231-44. 2001
    ..Since many clinical neuropathies result from inflammation/infection of peripheral nerves rather than frank physical trauma, understanding how immune activation alters pain processing may suggest novel approaches to pain control...
  80. ncbi Induction of Fos protein-like immunoreactivity in the trigeminal spinal nucleus caudalis and upper cervical cord following noxious and non-noxious mechanical stimulation of the whisker pad of the rat with an inferior alveolar nerve transection
    Hirofumi Nomura
    Department of Anesthesiology, School of Dentistry, Nihon University, 1 8 13, Kanda Surugadai, Chiyoda ku, 101 8310, Tokyo, Japan
    Pain 95:225-38. 2002
    ..These data suggest that the change in the numbers and spatial arrangement of nociceptive neurons in the Vc and C1 after IAN transection reflect the development of mechanical hyperalgesia in the area adjacent to the IAN innervated region...
  81. pmc Differential effects of synchronous and asynchronous multifinger coactivation on human tactile performance
    Tobias Kalisch
    Department of Theoretical Biology, Institute for Neuroinformatics, Ruhr University Bochum, D 44780 Bochum Germany
    BMC Neurosci 8:58. 2007
    ..Here we investigated the effect of different types of multifinger CA on the tactile performance of each finger of the right hand...
  82. ncbi Probing the human vestibular system with galvanic stimulation
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
    J Appl Physiol (1985) 96:2301-16. 2004
    ..Thus we propose the hypothesis that the otolithic component of the balance response originates from only the pars medialis of the utricular macula...
  83. ncbi Contribution of somatosensory cortex to responses in the rat cerebellar granule cell layer following peripheral tactile stimulation
    J Morissette
    Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA
    Exp Brain Res 109:240-50. 1996
    ..Our results demonstrate that SI is the primary contributor to the cerebellar long-latency response to peripheral tactile stimulation. These results are discussed in the context of Purkinje cell responses to tactile input...
  84. ncbi The somatotopic organization of cytoarchitectonic areas on the human parietal operculum
    Simon B Eickhoff
    Institut fur Medizin, Forschungszentrum Julich, Julich, Germany
    Cereb Cortex 17:1800-11. 2007
  85. ncbi Binding of movement, sound and touch: multimodal coordination dynamics
    J Lagarde
    Laboratory Efficience Deficience Motrice, University Montpellier 1, 700 Avenue Pic Saint Loup, 34090 Montpellier, France
    Exp Brain Res 173:673-88. 2006
    ..Because timing errors in multimodal coordination were systematically altered when compared to unimodal control conditions we are led to consider the role played by time delays in multimodal coordination dynamics...
  86. pmc Tool use changes multisensory interactions in seconds: evidence from the crossmodal congruency task
    Nicholas P Holmes
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Exp Brain Res 183:465-76. 2007
    ..Such enhancements are likely due to the increased behavioural relevance of visual stimuli as each tool use action is prepared before execution...
  87. ncbi Parietal cortex involvement in the localization of tactile and noxious mechanical stimuli: a transcranial magnetic stimulation study
    Carlo A Porro
    Department of Biomedical Sciences, Section of Human Physiology, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Behav Brain Res 178:183-9. 2007
    ..On these grounds, our findings support the existence of overlapping cortical populations in the contralateral parietal lobe, exerting a role in spatial discriminative aspects of touch and mechanically induced pain...
  88. pmc Dorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity
    Raymond D Hubbard
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 212:482-9. 2008
    ..This study provides new evidence for threshold-mediated degenerative changes in the context of behavioral hypersensitivity following nerve root compression...
  89. ncbi Pain and tactile stimuli during arterial puncture in preterm neonates
    Cláudia Maria Gaspardo
    Department of Neurology, Psychiatry and Medical Psychology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Pain 140:58-64. 2008
    ..There was evidence of distress responses immediately before and after a painful event, quite apart from the pain reaction to the puncture procedure...
  90. pmc Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha
    Yulian Wang
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Physiol 587:1739-53. 2009
    ..These studies provide novel mechanistic information potentially relevant to fetal lung development and to mechanical ventilation-induced lung injury...
  91. ncbi The effect of visual experience on the development of functional architecture in hMT+
    Emiliano Ricciardi
    Laboratory of Clinical Biochemistry and Molecular Biology, Department of Experimental Pathology, Medical Biotechnologies, Infectivology, and Epidemiology, University of Pisa Medical School, I 56126 Pisa, Italy
    Cereb Cortex 17:2933-9. 2007
  92. ncbi Localization of sensorimotor cortical rhythms induced by tactile stimulation using spatially filtered MEG
    William Gaetz
    Department of Diagnostic Imaging, Neuromagnetic Imaging Laboratory, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Neuroimage 30:899-908. 2006
  93. ncbi Left tactile extinction following visual stimulation of a rubber hand
    A Farne
    Department of Psychology, University of Bologna and S Camillo Hospital, Venezia, Italy
    Brain 123:2350-60. 2000
  94. ncbi Neurovascular coupling is brain region-dependent
    Ian M Devonshire
    Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
    Neuroimage 59:1997-2006. 2012
    ..The findings have important implications for studies that use functional brain imaging to investigate sub-cortical function and caution against the use of simple, linear mapping of imaging signals onto neural activity...
  95. ncbi Optical imaging of a tactile illusion in area 3b of the primary somatosensory cortex
    Li M Chen
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 302:881-5. 2003
    ..Thus, in contrast to traditional views of the body map, topographic representation in the SI reflects the perceived rather than the physical location of peripheral stimulation...
  96. ncbi The effect of distraction strategies on pain perception and the nociceptive flexor reflex (RIII reflex)
    Ruth Ruscheweyh
    Department of Neurology, University of Munster, Munster, Germany
    Pain 152:2662-71. 2011
    ..In addition, pain reduction by distraction seems to preferentially affect mechanisms of basal nociceptive transmission, not of temporal summation...
  97. pmc Working memory for vibrotactile frequencies: comparison of cortical activity in blind and sighted individuals
    Harold Burton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Hum Brain Mapp 31:1686-701. 2010
    ..However, these data suggest a role in sensory processing for tactile information in blind that parallels a similar contribution for visual stimuli in occipital cortex of sighted...
  98. ncbi The functional properties of barrel cortex neurons projecting to the primary motor cortex
    Takashi R Sato
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    J Neurosci 30:4256-60. 2010
    ..Our findings support the view that intermingled neurons in primary sensory areas send specific stimulus features to different parts of the brain...
  99. ncbi Central origin of secondary mechanical hyperalgesia
    Monika Klede
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurophysiol 90:353-9. 2003
    ..We conclude that the development of allodynia and punctate hyperalgesia in human skin is centrally mediated, whereas the axon reflex vasodilation is of peripheral origin...
  100. ncbi Tactile-auditory shape learning engages the lateral occipital complex
    Jung Kyong Kim
    Montreal Neurological Institute, McGill University, and Laboratory for Brain, Music, and Sound Research, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 31:7848-56. 2011
  101. ncbi Combined contribution of tactile and proprioceptive feedback to hand movement perception
    Caroline Blanchard
    Departement de Neurosciences, Aix Marseille Université CNRS, Laboratoire de Neurobiologie Intégrative et Adaptative UMR 6149, 3 place V Hugo, 13331 Marseille, France
    Brain Res 1382:219-29. 2011
    ..The kinesthetic illusions were copied by the subjects on-line with their left hand...

Research Grants78

  1. Traveling waves in visual cortex during binocular rivalry
    David Heeger; Fiscal Year: 2009
    ..What makes this phenomenon remarkable is the dissociation between a constant physical stimulation and fluctuating perceptual experience...
    Cutberto Garza; Fiscal Year: 1991
    ..between kinetic parameters underlying milk quality and quantity and specific endocrine responses and physical stimulation to the breast. 12-hr...
    Robert Ader; Fiscal Year: 1999
    ..emitted by "stressed" conspecifics, an ethologically appropriate stressful experience that involves no physical stimulation of the experimental animals...
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  5. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  6. Optical Imaging of Mechanical Nociception in SI Cortex
    Li Min Chen; Fiscal Year: 2006
    ..This study will provide insights into how sensory aspects of nociceptive information are encoded in each area of SI. [unreadable] [unreadable]..
  7. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
  8. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  10. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2009
    Jiska Cohen Mansfield; Fiscal Year: 2010
    ..PHS 398 (Rev. 05/01) Page 2 Principal Investigator/Program Director (Last, first, middle): Cohen-Mansfield, Jiska ..
    Harold Burton; Fiscal Year: 2009
    ..In all experiments blood oxygen level dependent response dynamics in visual and selective non-visual areas will be quantitatively analyzed and correlated with performance to determine likely causal relationships. ..
  13. Behaviorally Induced Cortical Plasticity
    RON FROSTIG; Fiscal Year: 2006
    ..In addition, such findings could have important implications for treatment of adult perceptual/motor disorders. [unreadable] [unreadable]..
  14. Cross Modal integration and Plasticity in SIV Cortex
    M Meredith; Fiscal Year: 2009
    ..abstract_text> ..
    Jiska Cohen Mansfield; Fiscal Year: 2006
    ..In that way, it presents an exciting prospect for improving the quality of life in demented persons, thereby reducing their caregivers' burden. ..
  16. CRCNS: Computational Models of Multisensory Processing
    M Alex Meredith; Fiscal Year: 2010
  17. Nornicotine for Treatment of Pain
    JOSEPH HOLTMAN; Fiscal Year: 2007
    ..This research project focuses on the development of a novel analgesic agent, nornicotine, for pain management. [unreadable] [unreadable] [unreadable]..
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
  19. Experience Dependent Plasticity of The Developing Cortex
    RON FROSTIG; Fiscal Year: 2007
    ..Further, such results would help in reassessment of the appropriateness of SC-raised rats to serve as models for the normal human brain. ..
  20. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2010
    ..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..
    Stephen Bruehl; Fiscal Year: 2002
    ..Greater pain duration is expected to be associated with smaller changes in the BP/pain relationship in response to opioid blockade. ..
  22. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  23. Sex differences in endogenous pain modulation
    RAIMI QUITON; Fiscal Year: 2006
    ..To accomplish these aims, psychophysical tests will be conducted in healthy human volunteers, using separate distracting, stressful, and painful conditioning protocols to activate endogenous analgesic systems. ..
    Barry Whitsel; Fiscal Year: 2007
    ..abstract_text> ..
    William Kennedy; Fiscal Year: 2001
    ..If NGF can enhance reinnervation in the skin wound these methods may be useful to evaluate the results of clinical therapeutic trials. ..
  26. Pain Regulatory Dysfunction in Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
    ..unreadable] [unreadable]..
    William Kennedy; Fiscal Year: 2002
    ..abstract_text> ..
    RON FROSTIG; Fiscal Year: 2003
    ..abstract_text> ..
  29. Norketamine for Treatment of Pain
    JOSEPH HOLTMAN; Fiscal Year: 2008
    ..abstract_text> ..
  30. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  31. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
    ..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. [unreadable] [unreadable] [unreadable]..
  32. Barany Society XXII Regular Meeting, Seattle, WA USA
    GEORGE GATES; Fiscal Year: 2002
    ..e., hair cell regeneration vs. development of a vestibular prosthesis. Younger scientists will have the opportunity to present their own work in either the platform or poster session. ..
  33. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
    Harold Burton; Fiscal Year: 2004
  35. Novel antibacterial agents resistant to inactivation by polyelectrolytes
    Paul A Janmey; Fiscal Year: 2010
    ..The current proposal will create or retain 4 jobs. ..
  36. Haptic Identification of Virtual Surfaces
    Vikram Chib; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  38. Prenatal Depression and a Yoga Intervention
    Tiffany M Field; Fiscal Year: 2010
    ..We would expect that yoga would decrease depression, increase vagal activity, decrease cortisol and increase gestational age (decrease prematurity). ..
  39. VOR adaptation/utility of saccades as rehab strategies
    Michael Schubert; Fiscal Year: 2008
    ..This is important for the long-term goals of this project, which are to determine the adaptive preferences that individuals with vestibular loss use to improve gaze stability. ..
    Jatin Vaidya; Fiscal Year: 2008
    ..Based on this research, it will be possible to develop prevention and treatment programs that take into consideration motivational processes that may be unique to adolescents. [unreadable] [unreadable] [unreadable]..
  41. Multi-scale mapping of 3D spatial-temporal cortical hemodynamics at the level of
    David Kleinfeld; Fiscal Year: 2008
    ..It will help define optical- and MRI-based diagnostics for the detection of dysfunction and clinically appropriate interventionist therapies. [unreadable] [unreadable] [unreadable]..
  42. The modulation of adenosine by temperature, oxygen and glucose
    SUSAN MASINO; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  43. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  44. Mechanisms of chemotherapy-evoked neuropathic pain
    Gary Bennett; Fiscal Year: 2009
  45. Stem Cell-Seeded ECM Scaffolds for Neurotransplantation
    MICHELLE LAPLACA; Fiscal Year: 2004
    ..abstract_text> ..
  46. Arm Kinematics in Hyperkinetic Cerebral Palsy
    Terence Sanger; Fiscal Year: 2005
    ..Hlatky will guide the design and implementation of clinical trials and outcome measure validation. The proposal includes coursework in cellular and molecular neurobiology and in the design of clinical research studies. ..
  47. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  48. Pain and drug abuse in HIV: Impact on health services
    JENNIE TSAO; Fiscal Year: 2005
    ..The proposed research agenda encompasses a set of analyses that will provide valuable insights into the health and well being of IDUs and drug dependent patients in care for HIV. ..
  49. Deafness Research Foundation Clinical Research Workshop
    GEORGE GATES; Fiscal Year: 2004
    ..Attendees will be physicians and clinicians in communication disorders, such as audiologists and speech/language pathologists. Fellowships will be available for attendees. ..
  50. Zeiss 510 Meta Confocal Laser Scanning Microscope
    Dean Dessem; Fiscal Year: 2003
    ..abstract_text> ..
  51. Vasopressin Effects on Social Communication
    RICHMOND THOMPSON; Fiscal Year: 2004
    ..abstract_text> ..
  52. Deafness Research Foundation Clinical Research Workshop
    GEORGE GATES; Fiscal Year: 2003
    ..Fellowships will be available for attendees with a demonstrated commitment to clinical research as evidenced by a preliminary research project and letters of support in their applications. ..
    Daniel Simons; Fiscal Year: 2003
  54. Motion Sensor Array for Vestibular-deficient Individuals
    Conrad Wall; Fiscal Year: 2005
    Gerald Dienel; Fiscal Year: 2003
    ..abstract_text> ..
  56. Neural Mechanisms of Chronic Muscle Pain Disorders
    Ranjinidevi Ambalavanar; Fiscal Year: 2007
    ..Agents capable of modulating SP, CGRP expression following decreased tissue pH may have potential not only as acute therapeutics but potentially as modulators of longer term nociceptive phenomena. [unreadable] [unreadable]..
    Klaus Bielefeldt; Fiscal Year: 2002
    ..A better understanding of mechanisms that control the calcium homeostasis may provide important insight into the etiology of diseases or lead to the development of novel treatment strategies for functional abnormalities. ..
  58. Development of QLF Handpiece for Early Caries Detection
    George Stookey; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  59. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Effects of phosphoinositidies on cytoskeletal structure
    Paul Janmey; Fiscal Year: 2006
    ..abstract_text> ..
    Joseph Bonanno; Fiscal Year: 2002
    ..If so, this could lead to the development of a provocative test for suitability of contact lens wear based on a quick and simple measure of corneal oxygen consumption. ..
    Kenneth Casey; Fiscal Year: 2002
    John Burns; Fiscal Year: 2002
    ..Documenting a link between anger and LP reactivity will give empirical justification for targeting problematic anger among CLPB patients, and will provide principles on which to found new intervention strategies. ..
  64. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
    KRISHNANKUTTY SATHIAN; Fiscal Year: 2003
    ..Correlation of the physiological data with clinic scores may establish if functional imaging or intraoperative recording are reliable predictors of patient outcome. ..
  66. Neural mechanisms of 3-D linear vestibuloocular reflex
    Chiju Chen Huang; Fiscal Year: 2009
    ..abstract_text> ..
  67. Natural History of Muscular & Reflex Changes in Stroke
    MEHDI MIRBAGHERI; Fiscal Year: 2004
    ..The changes in passive and intrinsic stiffness are likely to be highly correlated with severity of spasticity and inversely correlated with recovery of function. ..
  68. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2006
    ..Should these aims be met, the proposed model will be of great use in pre-clinical testing of novel cemented stem designs. ..
  69. Reinforced Variability and Operant Behavior
    Allen Neuringer; Fiscal Year: 2007
    ..These experiments analyze an important, but still not well-understood, aspect of behavior, namely, the control over behavioral variations exerted by reinforcing consequences. ..
  70. Neural Processes Underlying Pain Perception in Depression
    Irina Strigo; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  71. Treatment of Depressed Adolescents with Physical Illness
    Eva Szigethy; Fiscal Year: 2006
    ..abstract_text> ..
  72. Interaction torques in voluntary turning and reaching
    James R Lackner; Fiscal Year: 2010
    ..The experimental findings and analyses will provide a comprehensive evaluation of the role of feedforward predictive mechanisms in the control of reaching movements involving body rotation. ..
  73. Cortical Responses To Single & Multi-Site Skin Stimuli
    Mark Tommerdahl; Fiscal Year: 2005
  74. Management of Chronic Pain in Rehabilitation Medicine
    Mark Jensen; Fiscal Year: 2006
    ..A Scientific Core will provide scientific direction, project coordination, data collection and management, statistical support, and shared scientific expertise. ..
    DAVID LEWKOWICZ; Fiscal Year: 2003
    ..abstract_text> ..
  76. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    Herbert Terrace; Fiscal Year: 2005