Genomes and Genes
Summary: Experimental transplantation of neoplasms in laboratory animals for research purposes.
Publications313 found, 100 shown here
- Identification of human brain tumour initiating cellsSheila K Singh
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada
Nature 432:396-401. 2004....
- A human colon cancer cell capable of initiating tumour growth in immunodeficient miceCatherine A O'Brien
Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
Nature 445:106-10. 2007....
- Identification and expansion of human colon-cancer-initiating cellsLucia Ricci-Vitiani
Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
Nature 445:111-5. 2007..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellD Bonnet
Department of Genetics, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
Nat Med 3:730-7. 1997..The SL-ICs were able to differentiate in vivo into leukemic blasts, indicating that the leukemic clone is organized as a hierarchy...
- Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cellsMichael F Clarke
Stanford University School of Medicine, Stanford, California, USA
Cancer Res 66:9339-44. 2006
- Guidelines for the welfare and use of animals in cancer researchP Workman
Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Br J Cancer 102:1555-77. 2010....
- Phenotypic characterization of human colorectal cancer stem cellsPiero Dalerba
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 104:10158-63. 2007..These results validate the stem cell working model in human CRC and provide a highly robust surface marker profile for CRC stem cell isolation...
- Efficient tumour formation by single human melanoma cellsElsa Quintana
Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Nature 456:593-8. 2008..Modifications to xenotransplantation assays can therefore dramatically increase the detectable frequency of tumorigenic cells, demonstrating that they are common in some human cancers...
- Identification of cells initiating human melanomasTobias Schatton
Transplantation Research Center, Children s Hospital Boston and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 451:345-9. 2008..Identification of tumour-initiating cells with enhanced abundance in more advanced disease but susceptibility to specific targeting through a defining chemoresistance determinant has important implications for cancer therapy...
- Significance of CD90+ cancer stem cells in human liver cancerZhen Fan Yang
Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
Cancer Cell 13:153-66. 2008..Differential gene expression profiles were identified in the CD45(-)CD90+ and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls...
- The increasing complexity of the cancer stem cell paradigmJeffrey M Rosen
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 324:1670-3. 2009....
- Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenicLubna Patrawala
Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
Cancer Res 65:6207-19. 2005....
- Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cellsZhizhong Li
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Cell 15:501-13. 2009..Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies...
- Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cellsL Patrawala
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, 78957, USA
Oncogene 25:1696-708. 2006..Altogether, our results suggest that the CD44(+) PCa cell population is enriched in tumorigenic and metastatic progenitor cells...
- Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271Alexander D Boiko
Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
Nature 466:133-7. 2010....
- A tumorigenic subpopulation with stem cell properties in melanomasDong Fang
Program of Molecular and Cellular Oncogenesis, The Wistar Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA 19104, USA
Cancer Res 65:9328-37. 2005..Based on these findings, we propose that melanomas can contain a subpopulation of stem cells that contribute to heterogeneity and tumorigenesis. Targeting this population may lead to effective treatments for melanomas...
- Cancerous stem cells can arise from pediatric brain tumorsHouman D Hemmati
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 100:15178-83. 2003..This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors...
- Lysyl oxidase is essential for hypoxia-induced metastasisJanine T Erler
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 440:1222-6. 2006..Furthermore, LOX may be required to create a niche permissive for metastatic growth. Our findings indicate that LOX is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases...
- A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancerTheresa A DiMeo
Department of Anatomy and Cellular Biology, Sackler School, Tufts University School of Medicine, Boston, MA 02111, USA
Cancer Res 69:5364-73. 2009..Collectively, these results provide a molecular link between self-renewal, EMT, and metastasis in basal-like breast cancers...
- Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell lineJing Wang
State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, P R China
Cancer Res 67:3716-24. 2007..Taken together, our data shed light on tumorigenesis and therapeutic-resistant mechanisms, which are helpful for developing novel targets for effective clinical treatment of NPC...
- Enhancement of antitumor immunity by CTLA-4 blockadeD R Leach
Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
Science 271:1734-6. 1996..These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells...
- Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferationBenjamin W Purow
Neuro Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Res 65:2353-63. 2005..Notch-1 and its ligands may present novel therapeutic targets in the treatment of glioma...
- Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinomaShih Hwa Chiou
Institutes of Oral Biology, Traditional Medicine, and Anatomy and Cell Biology, National Yang Ming University, Taiwan, People s Republic of China
Clin Cancer Res 14:4085-95. 2008..Identification and characterization of CSC from OSCC facilitates the monitoring, therapy, or prevention of OSCC...
- GATA-3 links tumor differentiation and dissemination in a luminal breast cancer modelHosein Kouros-Mehr
Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
Cancer Cell 13:141-52. 2008..Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer...
- Side population cells in human cancersColleen Wu
Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Tower, East Tower, 101 College Street, Toronto, Ont, Canada M5G 1L7
Cancer Lett 268:1-9. 2008..Dye exclusion is a valuable technique as it identifies a unique population of cells with stem-like characteristics...
- CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosisSiddhartha Jaiswal
Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 138:271-85. 2009..We conclude that CD47 upregulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing...
- Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastomaEli E Bar
Johns Hopkins University School of Medicine, Department of Pathology, 720 Rutland Avenue, Ross Building 558, Baltimore, Maryland 21205, USA
Stem Cells 25:2524-33. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell lineToru Kondo
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
Proc Natl Acad Sci U S A 101:781-6. 2004..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
- Mouse models of advanced spontaneous metastasis for experimental therapeuticsGiulio Francia
The Molecular and Cellular Biology Research, Sunnybrook Health Science Centre, Toronto, Ontario M4N 3M5, Canada
Nat Rev Cancer 11:135-41. 2011....
- Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumorsPankaj Agarwalla
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunother 35:385-9. 2012..Sequential immunotherapy with GM-CSF-expressing irradiated glioma cells and CTLA-4 blockade synergistically prolongs survival in mice bearing established intracranial gliomas...
- PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patientsYoichi Nagata
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Cell 6:117-27. 2004..Thus, PTEN deficiency is a powerful predictor for trastuzumab resistance. Additionally, PI3K inhibitors rescued PTEN loss-induced trastuzumab resistance, suggesting that PI3K-targeting therapies could overcome this resistance...
- Malignant transformation in a nontumorigenic human prostatic epithelial cell lineS W Hayward
Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
Cancer Res 61:8135-42. 2001..The cells continued to express SV40T antigen. These cell strains, which are all derived from a common nontumorigenic progenitor, represent a useful resource for examining genetic and phenotypic changes during carcinogenesis...
- CXCR4 regulates growth of both primary and metastatic breast cancerMatthew C P Smith
Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
Cancer Res 64:8604-12. 2004..These data indicate that CXCR4 is required to initiate proliferation and/or promote survival of breast cancer cells in vivo and suggest that CXCR4 inhibitors will improve treatment of patients with primary and metastatic breast cancer...
- Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasisMaria I Harrell
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
Am J Pathol 170:774-86. 2007..Lymph node lymphangiogenesis and increased lymph flow through tumor-draining lymph nodes may actively promote metastasis via the lymphatics...
- Mesenchymal stem cells within tumour stroma promote breast cancer metastasisAntoine E Karnoub
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nature 449:557-63. 2007..Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells...
- Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisJing Yang
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Cell 117:927-39. 2004..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
- Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cellsKeith Syson Chan
Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94304 5542, USA
Proc Natl Acad Sci U S A 106:14016-21. 2009..Blockade of CD47 by a mAb resulted in macrophage engulfment of bladder cancer cells in vitro. In summary, we have identified a T-IC subpopulation with potential prognostic and therapeutic value for invasive bladder cancer...
- Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal regionFumihiko Ishikawa
Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho Tsurumi ku, Yokohama 230 0045, Japan
Nat Biotechnol 25:1315-21. 2007..These results indicate the potential utility of this AML xenograft model in the development of novel therapeutic strategies targeted at LS cells...
- The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cellsLi Bing Song
State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
J Clin Invest 119:3626-36. 2009..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
- A paracrine requirement for hedgehog signalling in cancerRobert L Yauch
Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 455:406-10. 2008..Taken together, these studies demonstrate a paracrine requirement for Hh ligand signalling in the tumorigenesis of Hh-expressing cancers and have important implications for the development of Hh pathway antagonists in cancer...
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9Andrei V Krivtsov
Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
Nature 442:818-22. 2006..Our findings define progression from normal progenitor to cancer stem cell, and suggest that targeting a self-renewal programme expressed in an abnormal context may be possible...
- Modeling of tumor growth and anticancer effects of combination therapyGilbert Koch
Department of Mathematics and Statistics, University of Konstanz, Germany
J Pharmacokinet Pharmacodyn 36:179-97. 2009..The unique feature of the presented approach is the ability to characterize the nature of combined drug interaction as well as to quantify the intensity of such interactions by assessing the time course of combined drug effect...
- Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cellsDavid C Taussig
Department of Medical Oncology, St Bartholomew s Hospital, London, UK
Blood 112:568-75. 2008..More importantly, the work suggests that there is greater variation in the phenotypes of leukemia-initiating cells than previously suggested...
- Reprogramming metastatic tumour cells with embryonic microenvironmentsMary J C Hendrix
Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Nat Rev Cancer 7:246-55. 2007..This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration...
- A new model of patient tumor-derived breast cancer xenografts for preclinical assaysElisabetta Marangoni
U612 Institut National de la Sante et de la Recherche Medicale, Pharmacologie Préclinique Antitumorale, Paris Anatomie et Cytologie Pathologique, Hopital Trousseau, Tours, France
Clin Cancer Res 13:3989-98. 2007..To establish a panel of human breast cancer (HBC) xenografts in immunodeficient mice suitable for pharmacologic preclinical assays...
- Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivoSimone Fulda
University Children s Hospital, Ulm, Germany
Nat Med 8:808-15. 2002..Thus, Smac agonists are promising candidates for cancer therapy by potentiating cytotoxic therapies...
- Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell lineMassimiliano Cariati
Department of Academic Oncology, King s College London and Guy s and St Thomas NHS Foundation Trust, United Kingdom
Int J Cancer 122:298-304. 2008..These findings support the existence of a highly tumourigenic sub-population in breast cancer cells. Furthermore, it shows alpha6-integrin as a potential therapeutic target aimed at tumour-generating subsets of breast cancer cells...
- Gamma delta T cells provide an early source of interferon gamma in tumor immunityYunfei Gao
Section of Rheumatology, Yale School of Medicine, 300 Cedar Street, CAB Building Room S517, New Haven, CT 06520, USA
J Exp Med 198:433-42. 2003..These results demonstrate that gammadelta T cells can play a necessary role in tumor immunity through provision of an early source of IFN-gamma that in turn may regulate the function of tumor-triggered alphabeta T cells...
- The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signalingDouglas S Micalizzi
Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Clin Invest 119:2678-90. 2009..Our findings indicate that Six1, acting through TGF-beta signaling and EMT, is a powerful and global promoter of cancer metastasis...
- The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formationLisa M J Lee
Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60614 3394, USA
Dev Dyn 233:1560-70. 2005..These results demonstrate the utility of the zebrafish embryonic model for the study of tumor cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions...
- HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancerMerel Gijsen
Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
PLoS Biol 8:e1000563. 2010..Our results may also have implications for resistance to other therapies targeting HER receptors...
- The roles of IFN gamma in protection against tumor development and cancer immunoeditingHiroaki Ikeda
Department of Pathology and Immunology, Center for Immunology, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cytokine Growth Factor Rev 13:95-109. 2002....
- Bmi-1 determines the proliferative capacity of normal and leukaemic stem cellsJulie Lessard
Laboratory of Molecular Genetics of Hemopoietic Stem Cells, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
Nature 423:255-60. 2003..Complementation studies showed that Bmi-1 completely rescues these proliferative defects. These studies therefore indicate that Bmi-1 has an essential role in regulating the proliferative activity of both normal and leukaemic stem cells...
- Single-vector inducible lentiviral RNAi system for oncology target validationDmitri Wiederschain
Oncology Research, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
Cell Cycle 8:498-504. 2009..The versatile and robust inducible lentiviral RNAi system reported herein can therefore serve as a powerful tool to rapidly reveal tumor cell dependence...
- Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cellsMax G Bachem
Department of Clinical Chemistry, University of Ulm, D 89070 Ulm, Germany
Gastroenterology 128:907-21. 2005..The aims of this study were to examine the cellular and molecular mechanisms of fibrogenesis associated with pancreatic adenocarcinomas...
- PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerJ Li
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
Science 275:1943-7. 1997..These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions...
- Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinicR M Hoffman
AntiCancer, Inc, San Diego, CA 92111, USA
Invest New Drugs 17:343-59. 1999..These unique SOI models have been used for innovative drug discovery and mechanism studies and serve as a bridge linking pre-clinical and clinical research and drug development...
- The microRNAs miR-373 and miR-520c promote tumour invasion and metastasisQihong Huang
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Nat Cell Biol 10:202-10. 2008..Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs...
- Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growthKeiichi Kondo
Department of Adult Oncology, Dana Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA
PLoS Biol 1:E83. 2003..These results establish that tumor suppression by pVHL is linked to regulation of HIF target genes...
- Angiogenesis-independent tumor growth mediated by stem-like cancer cellsPer Ø Sakariassen
NorLux NeuroOncology, Department of Biomedicine, University of Bergen, N 5020 Bergen, Norway
Proc Natl Acad Sci U S A 103:16466-71. 2006..This article underlines the need for developing therapies that specifically target the stem-like cell pools in tumors...
- CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cellsZ Qin
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Immunity 12:677-86. 2000..This shows that an effective anti-tumor response involves communication between CD4+ T cells and nonhematopoietic cells, most likely within the tumor stroma, and that tumor immunity must not entirely rely on direct tumor cell killing...
- Side population cells isolated from mesenchymal neoplasms have tumor initiating potentialColleen Wu
Program in Developmental and Stem Cell Biology, Toronto Medical Discovery Tower, Hospital for Sick Children, Toronto, ON, Canada
Cancer Res 67:8216-22. 2007..In addition, our data suggest that the proportion of SP cells could be used as a prognostic factor and that therapeutically targeting this subpopulation of cells could be used to improve patient outcome...
- Involvement of chemokine receptors in breast cancer metastasisA Muller
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
Nature 410:50-6. 2001..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
- The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesisJ Oh
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, 606 8501, Kyoto, Japan
Cell 107:789-800. 2001..These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis...
- Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancerJindan Yu
Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Cell 12:419-31. 2007..Taken together, we demonstrate the power of integrating multiple diverse genomic data to decipher targets of disease-related genes...
- Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discoveryD D Fang
Department of Protein Therapeutics, Celera, Inc, Rockville, MD 20850, USA
Br J Cancer 102:1265-75. 2010..Additional validation of the CSC properties of tumour spheres would support their use as CSC models and provide an opportunity to discover additional CSC cell surface markers to aid in CSC detection and potential elimination...
- Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancerLakshmi Sampath
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
J Nucl Med 48:1501-10. 2007..The stoichiometric ratios "n" and "m" refer to the number of diethylenetriaminepentaacetic acid dianhydride (DTPA) and IRDye 800CW molecules bound per trastuzumab molecule, respectively...
- Endostatin inhibits lymph node metastasis by a down-regulation of the vascular endothelial growth factor C expression in tumor cellsShunsuke Fukumoto
Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 1 1 Maidashi 3 chome, Higashi ku, Fukuoka 812 8582, Japan
Clin Exp Metastasis 22:31-8. 2005..These findings suggested that endostatin inhibited lymphangiogenesis and lymph node metastasis by suppressing the production of VEGF-C in tumor cells...
- Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determinationMary J C Hendrix
Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242, USA
Cancer Res 62:665-8. 2002....
- Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiformeCaterina Giannini
Departments of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Neuro Oncol 7:164-76. 2005..The fact that such studies were carried out by using an invasive tumor model in an anatomically appropriate context should ensure a rigorous preclinical assessment of agent efficacy...
- Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafishMaryann Haldi
Phylonix Pharmaceuticals, Inc, 100 Inman Street, Suite 300, Cambridge, MA 02139, USA
Angiogenesis 9:139-51. 2006..The zebrafish model offers a rapid efficient approach for assessing human cancer cells at various stages of tumorigenesis...
- Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinaseF M Sirotnak
Department of Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 6:4885-92. 2000..They also suggest significant clinical benefit from ZD1839 in combination with a variety of widely used cytotoxic agents...
- IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicityV Shankaran
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nature 410:1107-11. 2001..However, this process also leads to the immunoselection of tumour cells that are more capable of surviving in an immunocompetent host, which explains the apparent paradox of tumour formation in immunologically intact individuals...
- A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemiaG G Wulf
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Blood 98:1166-73. 2001..They also suggest a mechanism by which SP cells could escape the effects of cytostatic drugs and might eventually contribute to leukemia relapse. (Blood. 2001;98:1166-1173)..
- Targeting hypoxia cell signaling for cancer therapyGiovanni Melillo
Developmental Therapeutics Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
Cancer Metastasis Rev 26:341-52. 2007..A rational development plan aimed to validate target inhibition in preclinical models and early clinical trials is essential for a rapid translation of these agents to the treatment of human cancers...
- Tumor growth need not be driven by rare cancer stem cellsPriscilla N Kelly
Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
Science 317:337. 2007..We suggest that the low frequency of tumor-sustaining cells observed in xenotransplantation studies may reflect the limited ability of human tumor cells to adapt to growth in a foreign (mouse) milieu...
- Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistancePriscilla P L Chiu
Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada
Blood 116:5268-79. 2010..Our results establish that primary CD1a(-) T-ALL cells are functionally distinct from CD1a(+) cells and that the CD7(+)CD1a(-) subset is enriched for L-IC activity that may be involved in mediating disease relapse after therapy...
- Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient miceErika Cretney
Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A Beckett Street, East Melbourne, 8006 Victoria, Australia
J Immunol 168:1356-61. 2002..TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells...
- The tumor macroenvironment and systemic regulation of breast cancer progressionZafira Castaño
Department of Medicine, Hematology Division, Brigham and Women s Hospital, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA
Int J Dev Biol 55:889-97. 2011..In this review, we address the systemic, or "macroenvironmental", contribution to tumor initiation and progression and what is known about how a pro-tumorigenic systemic environment is established...
- Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancerDong Liang Chen
State Key Laboratory of Oncology in South China
Carcinogenesis 34:803-11. 2013..Taken together, these results demonstrated that overexpression of PXN induced by suppression of miR-137 promotes tumor progression and metastasis and could serve as an independent prognostic indicator in CRC patients...
- Cytohesins are cytoplasmic ErbB receptor activatorsAnke Bill
LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, Laboratory of Chemical Biology, Rheinische Friedrich Wilhelms Universitat Bonn, Gerhard Domagk Str 1, 53121 Bonn, Germany
Cell 143:201-11. 2010..Our results establish cytohesins as cytoplasmic conformational activators of ErbB receptors that are of pathophysiological relevance...
- Establishment and characterization of a primary human chordoma xenograft modelI Mei Siu
Department of Neurosurgery, The Johns Hopkins University, Baltimore, MD, USA
J Neurosurg 116:801-9. 2012..Currently, there are only a few established chordoma cell lines and no primary xenograft model. In this study, the authors aimed to develop a primary chordoma xenograft model...
- Quantified tumor t1 is a generic early-response imaging biomarker for chemotherapy reflecting cell viabilityPaul M J McSheehy
Oncology Research and Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
Clin Cancer Res 16:212-25. 2010..Identification of a generic response biomarker by comparison of chemotherapeutics with different action mechanisms on several noninvasive biomarkers in experimental tumor models...
- Transgenic Polyoma middle-T mice model premalignant mammary diseaseJ E Maglione
Department of Medicine, Cancer Center, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cancer Res 61:8298-305. 2001..These results support the use of PyV-mT transgenic mice as a model for investigating the multistep progression of malignant mammary tumorigenesis and metastasis...
- Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasisQin Chen
Department of Pharmacological Sciences and Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA
Sci Signal 5:ra79. 2012....
- Self-renewal gene tracking to identify tumour-initiating cells associated with metastatic potentialC Y Darini
CNRS, Institute of Biology Development and Cancer, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, Nice Cedex 2, France
Oncogene 31:2438-49. 2012..Consequently, it provides an appropriate model to develop novel therapies aiming to strike down TICs by targeting self-renewal genes, therefore efficient to reduce tumour growth and metastatic disease...
- Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cellsLubna Patrawala
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA
Cancer Res 67:6796-805. 2007..These observations together suggest that prostate cancer cells are organized as a hierarchy...
- L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinomaJeong Ki Min
Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungnam National University School of Medicine, Daejon, Korea
Clin Cancer Res 16:3571-80. 2010..Intrahepatic cholangiocarcinoma (ICC), a highly malignant hepatobiliary cancer, has a poor prognosis and is refractory to conventional therapies. The aim of this study is to discover a novel molecular target for the treatment of ICC...
- The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castrationJichao Qin
Department of Molecular Carcinogenesis, University of Texas M D Anderson Cancer Center, Science Park, Smithville, TX 78957, USA
Cell Stem Cell 10:556-69. 2012..Altogether, our study suggests that PSA(-/lo) cells may represent a critical source of castration-resistant PCa cells...
- Identification of T-lymphocytic leukemia-initiating stem cells residing in a small subset of patients with acute myeloid leukemic diseaseRuth M Risueno
Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, USA
Blood 117:7112-20. 2011..These findings have implications both for the basic biology of CSC function, and for the use of in vivo models of the leukemogenic process in preclinical or diagnostic studies...
- Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomasJessica Kr Boult
CRUK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK
J Pathol 225:344-52. 2011..DDAH1 is an important mediator of tumour progression, but appears to have addition roles independent of its metabolism of ADMA, which need to be considered in therapeutic strategies targeted against the NO/DDAH pathway in cancer...
- Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11)Susan J Zunino
United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, United States
Cancer Lett 296:49-54. 2010..These data describe a novel inducible model for investigating multi-drug resistance mechanisms in high-risk t(4;11) ALL...
- High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemiasS Morisot
Department of Pediatrics, Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Leukemia 24:1859-66. 2010..This very high frequency of LSCs suggests that a hierarchical LSC model is not valuable for poor-outcome ALL...
- Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemiaRichard T Williams
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Genes Dev 21:2283-7. 2007..Hence, salutary cytokines in the hematopoietic microenvironment can facilitate leukemic proliferation and confer resistance to targeted therapy...
- Brief report: a bioassay to identify primary human prostate cancer repopulating cellsRoxanne Toivanen
Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
Stem Cells 29:1310-4. 2011..Thus, this new protocol efficiently established tumors and enabled proliferative expansion of both intact tumor tissue and fractionated cancer cells, providing a bioassay to identify and therapeutically target PCa repopulating cells...
- Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasionE S McCoy
Department of Neurobiology and Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Neuroscience 168:971-81. 2010..AQP4 expressing glioma cells showed significantly reduced invasion compared to AQP1 and S180 expressing tumors as determined by quantitative stereology, consistent with a differential role for AQP1 and AQP4 in this process...
- Multimodality imaging of IL-18--binding protein-Fc therapy of experimental lung metastasisQizhen Cao
The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
Clin Cancer Res 14:6137-45. 2008....
- A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapySi Tuen Lee-Hoeflich
Department of Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
Cancer Res 68:5878-87. 2008....
- Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and gliomaQin Shu
Laboratory of Molecular Neuro Oncology, Texas Children s Cancer Center, Texas Children s Hospital, 6621 Fannin St, MC 3 3320, Houston, Texas 77030, USA
Stem Cells 26:1414-24. 2008..Disclosure of potential conflicts of interest is found at the end of this article...
- Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer modelH Y Shi
Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
Cancer Res 61:6945-51. 2001..Thus, maspin can block primary tumor growth as well as invasion and metastasis. These data support the concept that maspin has a strong protective role against tumor progression...
- Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cellsOmer H Yilmaz
Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Nature 441:475-82. 2006..Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to deplete cancer stem cells without damaging normal stem cells...
- Plasmalogen Metabolism by iPLA2 in Ischemic MyocardiumJane McHowat; Fiscal Year: 2005..Our long-term objectives are to determine the metabolic pathways that are appropriate targets for novel therapeutic strategies to alleviate the morbidity and mortality of ischemic heart disease in man. ..
- Non-Viral Vectors for Liver Gene TransferFeng Liu; Fiscal Year: 2006..The therapeutic effects on the metabolic disease on phenylketonuria (PKU) mice, will be examined after the PAH gene transfer using the approach in this proposal. ..
- Adenoviral GFP targeting of metastatic human tumors using multiple delivery routeHiroyuki Kishimoto; Fiscal Year: 2008..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
- Imageable tumor-targeting bacteriaMing Zhao; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Dual-color tumor-host imaging modelsMeng Yang; Fiscal Year: 2007..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
- Therapeutic hair follicle-derived neurospheresMeng Yang; Fiscal Year: 2007..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
- Orthotopic models of tumor angiogenesis and blood flowMeng Yang; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAYYuying Tan; Fiscal Year: 2002..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- MTOR as a Therapeutic Target in Childhood CancerPeter Houghton; Fiscal Year: 2005..abstract_text> ..
- Targeted tumoricidal bacteriaMing Zhao; Fiscal Year: 2007..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
- Inhibitors of 5alpha-reductase for acne therapyLingna Li; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
- Discovery of novel fluorescent reporter genesMing Zhao; Fiscal Year: 2004..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
- Enzyme therapy for hyperhomocysteinemiaYuying Tan; Fiscal Year: 2005..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
- Omega-3 fat to reduce risk for breast cancerWANDA ELAINE HARDMAN; Fiscal Year: 2010....
- IAPs As Novel Targets for Cancer TherapyLily Yang; Fiscal Year: 2007..Results from this research should allow us to determine if IAPs are novel molecular targets for the development of cancer-specific therapeutic approaches. ..
- RAIT of Pancreatic Cancer with Humanized PAM4ROBERT SHARKEY; Fiscal Year: 2005..The trial will be conducted at the Garden State Cancer Center and Johns Hopkins University School of Medicine. CMMI will be responsible for monitoring the study's progress. ..
- N-3 fatty acid & binding protein MRG on mammary tumorYUENIAN SHI; Fiscal Year: 2006..These studies will help to identify MRG as mediator for differentiation for mammary gland and for interaction with n-3 PUPA on inhibition of mammary tumorigenesis. ..
- Correlative Imaging of Tumor AngiogenesisSanjiv Gambhir; Fiscal Year: 2004..We plan to perform pharmacokinetics and toxicology studies with preclinical materials and prepare an agent for gamma and SPECT imaging in clinical studies and file an IRB for cancer angiogenesis evaluation. ..
- MoAbs for the Management of Pancreatic CancerDavid Gold; Fiscal Year: 2005..Finally, a PAM4IL2 fusion protein will be examined for its ability to enhance tumor uptake of a subsequently administered radiolabeled PAM4 antibody. ..
- Progesterone regulation of human luteal cell viabilityJohn Peluso; Fiscal Year: 2006..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
- ROLES OF NITRIC OXIDE AND OXYGEN IN OCULAR MELANOMARODNEY BRAUN; Fiscal Year: 2002....
- MECHANISMS FOR CHEMOPREVENTION OF COLON CANCERCHINTHALAPALLY RAO; Fiscal Year: 2004..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
- Pretargeting mouse tumor with anti-PSMA antibody-MORFGuozheng Liu; Fiscal Year: 2005..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
- Development of Digital SNP Analysis in Cancer DetectionIe Ming Shih; Fiscal Year: 2005..Thus, the encouraging results from this study will ensure the detection of AI in plasma a promising cancer research direction for further exploration. ..
- Preclin. model for prevention of NSCLC in former smokersHILDEGARD SCHULLER; Fiscal Year: 2006....
- 9/10TH Conf./Cancer Therapy/Antibody/ImmunoconjugatesDavid Goldenberg; Fiscal Year: 2004..The conference chairman, Dr. Goldenberg, has secured two outstanding scientists as co-chairmen, Drs. Ralph Reisfeld (Scripps) and Edward Sausville (NCI). ..
- CMMI Human Subject Research Enhancement ProgramDavid Goldenberg; Fiscal Year: 2002..3.) Provide travel expenses and educational materials for IRB members, investigators, and Regulatory Affairs Office personnel to attend meetings for educational enhancement. ..
- Uveal Melanoma MicrometastasisPierre L Triozzi; Fiscal Year: 2010..Micrometastases, microscopic deposits of tumor that have spread via the bloodstream, are present in many patients with uveal melanoma at diagnosis. This project will test new methods of identifying and inhibiting these deposits. ..
- ADENOVIRUS E3 PROTEINS AND TUMOR NECROSIS FACTORWilliam Wold; Fiscal Year: 2001....
- YELLOW FEVER 17D-BASED CHIMERIC FLAVIVIRUS VACCINESWilliam Wold; Fiscal Year: 2002....
- NEUROCHEMISTRY OF NOCICEPTIONPatrick Mantyh; Fiscal Year: 2002....
- CTGF in Pancreatic Tumor GrowthAmato J Giaccia; Fiscal Year: 2010..In summary, the proposed studies are intended to address an important mechanism by which CTGF affects tumor progression in pancreatic cancers and to determine how effective it is in combination therapy to bring it to the clinic. ..
- AAV-Based Plasmacytoid Dendritic Cell Cancer VaccinePierre L Triozzi; Fiscal Year: 2010....
- Hamster Model for Oncolytic Adenovirus VectorsWILLIAM SM WOLD; Fiscal Year: 2010..Although not proposed specifically in this application, these studies should also provide novel information on adenovirus pathogenesis. ..
- Peptide Derivatives to treat Urinary Tract InfectionsLaszlo Otvos; Fiscal Year: 2003..Our hope is that by the end of the grant period, we will be able to provide a pyrrhocoricin-derived peptide for ensuing US Food and Drug Administration-approved preclinical and clinical evaluation against urinary tract infections. ..
- Bispecific Antibody Pretargeted Therapy of Pancreatic CancerROBERT SHARKEY; Fiscal Year: 2008..Overall, these studies will assist in establishing whether this type of pretargeting approach could have a role in the clinical management of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
- Syrian Hamster as a Permissive Model for Testing Anti-Adenovirus DrugsWilliam Wold; Fiscal Year: 2007..Success in this project could lead to the eventual approval of drugs to treat adenovirus infections in immunosuppressed patients. [unreadable] [unreadable] [unreadable]..
- Intrnational Clubfoot SymposiumJose Morcuende; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITYRichard Santen; Fiscal Year: 2009..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
- Mechanisms of chemopreventive effect of resveratrolZigang Dong; Fiscal Year: 2009..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
- Pathogenic Mechanism of Polycystic Kidney DiseaseYumay Chen; Fiscal Year: 2010..Our studies will provide novel insight into the molecular pathogenesis of PKD. They will help explain why cysts progress at different rates and how therapies to slow the progression of PKD can be designed rationally. ..
- Molecular Basis of Flavivirus NeurovirulenceWilliam Wold; Fiscal Year: 2007..abstract_text> ..
- Multimodality Imaging of Cell Mediated Gene TransferSanjiv Gambhir; Fiscal Year: 2007..Furthermore, the methodologies developed in this proposal will help other investigators to implement various models in which imaging of cell survival and cardiac gene therapy are important. [unreadable] [unreadable] [unreadable]..
- Cancer Pain and Breast Tumor Metastasis to BonePatrick Mantyh; Fiscal Year: 2007..Information from these investigations should expand our understanding of the mechanisms that generate and maintain bone cancer pain and lead to the development of more effective therapies for treating bone cancer pain. ..
- Molecular basis of arsenic-induced cell transformationZigang Dong; Fiscal Year: 2007..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
- LIGHT DURING DARKNESS AND BREAST CANCER PROGRESSIONDavid Blask; Fiscal Year: 2004....
- Role of Fas/NF kB in H.pylori induced gastric carcinomaJeanMarie Houghton; Fiscal Year: 2003..Defining the regulation of these pathways will help define the complex relationship helicobacter shares with its host. ..
- Inhibition of Fas-apoptosis in Gastric CancerJeanMarie Houghton; Fiscal Year: 2010..These studies will provide critical insight into novel preventive, and anti-cancer strategies aimed at restoring Fas sensitivity within tumor cells and provide a new direction for cancer treatment. ..
- Tumor suppressor gene at 6q in adenoid cystic carcinomaChristopher Moskaluk; Fiscal Year: 2006..Since AGO appears to have a smaller number of genetic changes than these other malignancies, it may serve as a simpler system to identify the 6q tumor suppressor gene. ..
- Ultrasound Monitoring of Rat Metastatic Uveal MelanomaRODNEY BRAUN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Enhancement of Ad-p53 Therapy with Intratumoral TaxaneGEORGE YOO; Fiscal Year: 2004..Favorable data from the proposed project will lead to the development of clinical trials using intratumoral and intra-wound injections of docetaxel and Ad-p53. ..
- Antifolate Resistance in OsteosarcomaRichard Gorlick; Fiscal Year: 2007....
- Radiolabeled RGD Peptides for Breast Cancer Imaging and TherapyZhen Cheng; Fiscal Year: 2010..The same ligands labeled with therapeutic isotopes will allow targeted internal radiotherapy of integrin positive tumors. ..
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMHECTOR MOBINE; Fiscal Year: 2008..The findings may not only afford further appreciation of the pathophysiology and etiology of peripartum cardiomyopathy but also of general mechanisms in disease progression. [unreadable] [unreadable] [unreadable]..
- Photons plus Ultrasound: Imaging and SensingLihong Wang; Fiscal Year: 2006..unreadable] [unreadable] Previous critiques have been answered particularly as they addressed the participation of women and mechanisms to attract and reward students. [unreadable] [unreadable] [unreadable]..
- RARbeta in Melanoma: Epigenetic Regulation by NutrientsRichard Niles; Fiscal Year: 2007..Depending on results obtained, this investigation can be translated into nutritional studies with animal models of melanoma. [unreadable] [unreadable] [unreadable]..
- Chemo/Antiretroviral therapy for HTLV-1 ATLLLee Ratner; Fiscal Year: 2005..abstract_text> ..
- Interaction of HIV gp120 & G protein coupled receptorsLee Ratner; Fiscal Year: 2007..abstract_text> ..
- Third Generation Antiopportunistic AgentsAleem Gangjee; Fiscal Year: 2003..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
- Antitumor Antimitotics That Reverse Tumor ResistanceAleem Gangjee; Fiscal Year: 2010..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
- Single Agents with Designed Combination Chemotherapy PotentialAleem Gangjee; Fiscal Year: 2010..abstract_text> ..
- Novel Bisphosphonates for Multiple Myeloma TherapyMONICA REINHOLZ; Fiscal Year: 2004..Successful development of this new drug-design concept would provide a biologically and commercially superior approach for the treatment and prevention of skeletal-related complications of malignancy. ..
- Regulation of Proinflammatory Signaling Pathways in CFTRHARVEY BRUCE POLLARD; Fiscal Year: 2010..The proposal is both unique and innovative by directing the investigation to the biology and chemistry of the IL-8 promoter in CF lung epithelial cells, both in vitro and in vivo. ..
- STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTSAleem Gangjee; Fiscal Year: 2001..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
- NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORSAleem Gangjee; Fiscal Year: 2004....
- Development of Soluble FcR-Ig Fusion ProteinsLeslie Johnson; Fiscal Year: 2004..We believe that an FcR blockade would also be potentially useful in treating autoimmune hemolytic anemia, lupus, rheumatoid arthritis, Guillain-Barre syndrome and stiff man's syndrome. ..
- Novel Single, Dual and Multitargeted Inhibitors of RTKsAleem Gangjee; Fiscal Year: 2007..abstract_text> ..
- Novel Bisphosphonates for Breast Cancer TherapyMONICA REINHOLZ; Fiscal Year: 2002..Proposed Commercial Application: Not Available. ..
- Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor AgentsAleem Gangjee; Fiscal Year: 2010....
- FcRlll Blockade as a Treatment for Autoimmune DiseaseLeslie Johnson; Fiscal Year: 2004..the studies outlined in this application will provide the basis for expanded production, characterization and further safety and efficacy studies of this molecule in small animals and primates, ultimately leading to human clinical trials ..
- Novel, P. jirovecii Specific Antipneumocystis AgentsAleem Gangjee; Fiscal Year: 2009..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
- Imageable Mouse Models of Pancreatic CancerMichael Bouvet; Fiscal Year: 2008..Using such dual-colored imaging techniques, a better characterization of the tumor-host interactions in pancreatic cancer can be made. ..
- Changes in Functional Status Across Therapy for Primary GliomaLee Jones; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ENHANCEMENT OF HPV16 E6 & E7-SPECIFIC ANTITUMOR IMMUNITYT C Wu; Fiscal Year: 2001..5) Perform head-to-head comparison of various E6, E7 and chimeric E6E7 vaccines in antitumor immunity using E6 and E7 expressing murine model tumors. ..
- PHYTOMELATONIN AND CANCER PREVENTIONDavid Blask; Fiscal Year: 2004....
- PREVENTIVE/THERAPEUTIC HPV VACCINE DEVELOPMENTT C Wu; Fiscal Year: 2003..A.5 Evaluate the mechanisms of the anti-tumor immunity induced by vaccination. ..
- Protein Kinase G Regulation of Granulosa Cell ViabilityJohn Peluso; Fiscal Year: 2006..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
- Regulation of Oocyte Viability by Granulosa Cell ContactJohn Peluso; Fiscal Year: 2004..abstract_text> ..
- HYPOXIA AND GENE REPRESSIONAmato Giaccia; Fiscal Year: 2009..We will test these hypotheses through a combination of genetic and biochemical approaches in cell lines and in mice. ..
- Endothelial Regulation of T Cell Homing in Ovarian CarcinomaGeorge Coukos; Fiscal Year: 2007..Results obtained from the proposed studies will generate novel ideas for the development of molecular tools to circumvent impediments to tumor immunotherapy. ..
- Mutation of the Id1 gene in squamous cell cancerJizhen Lin; Fiscal Year: 2005..The study not only improves our understanding of the molecular mechanisms on the carcinogenesis and angiogenesis of SCC but also provides a foundation for innovative treatment against SCC in the future. ..