Genomes and Genes
phase contrast microscopy
Summary: A form of interference microscopy in which variations of the refracting index in the object are converted into variations of intensity in the image. This is achieved by the action of a phase plate.
Publications237 found, 100 shown here
- Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sectionsO Cussenot
Département de Recherche en Urologie, Hopital Saint Louis, Paris, France
Exp Cell Res 214:83-92. 1994....
- The effect of an age-related hearing loss gene (Ahl) on noise-induced hearing loss and cochlear damage from low-frequency noiseGary W Harding
Department of Otolaryngology, Box 8115, Washington University School of Medicine, St Louis, MO 63110, USA
Hear Res 204:90-100. 2005..However, this appeared not to be the case for PTS. The Ahl gene appears to play a role in susceptibility to NIHL but, other genes as well as systemic and local factors must also be involved...
- Influence of channel width on alignment of smooth muscle cells by high-aspect-ratio microfabricated elastomeric cell culture scaffoldsJohn D Glawe
Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA
J Biomed Mater Res A 75:106-14. 2005....
- Structural changes in epidermal scale and appendages as indicators of defective TGM1 activityRobert H Rice
Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616 8588, USA
Arch Dermatol Res 297:127-33. 2005..Both epidermal scale and nail from the index case lacked the prominent cell borders that were visible by phase contrast microscopy after detergent extraction of control samples...
- Embryonic stem cells and cardiomyocyte differentiation: phenotypic and molecular analysesHong Wei
Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA
J Cell Mol Med 9:804-17. 2005..With these issues in mind, this review will focus on the differentiation of pluripotent embryonic stem cells into cardiomyocytes as a developmental model, and the possible use of ES cell-derived cardiomyocytes as source of donor cells...
- Medical phase contrast x-ray imaging: current status and future prospectsR A Lewis
Monash Centre for Synchrotron Science and School of Physics and Materials Engineering, Monash University, Victoria 3800, Australia
Phys Med Biol 49:3573-83. 2004..The current state of the art is reviewed...
- Characterization of bacterial spore germination using integrated phase contrast microscopy, Raman spectroscopy, and optical tweezersLingbo Kong
Department of Physics, East Carolina University, Greenville, North Carolina 27858 4353, USA
Anal Chem 82:3840-7. 2010We present a methodology that combines external phase contrast microscopy, Raman spectroscopy, and optical tweezers to monitor a variety of changes during the germination of single Bacillus cereus spores in both nutrient (l-alanine) and ..
- Vibrational phase contrast microscopy by use of coherent anti-Stokes Raman scatteringM Jurna
Optical Sciences Group, MESA Institute for Nanotechnology, Faculty of Science and Technology TNW, University of Twente, The Netherlands
Phys Rev Lett 103:043905. 2009..The detection of the phase of the vibrational motion can be regarded as a vibrational extension of the linear (refractive index) phase contrast microscopy introduced by Zernike around 1933.
- Tomographic phase microscopyWonshik Choi
G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue 6 014, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Methods 4:717-9. 2007..Our results will permit quantitative characterization of specimen-induced aberrations in high-resolution microscopy and have multiple applications in tissue light scattering...
- Tracking retrograde flow in keratocytes: news from the frontPascal Vallotton
Laboratory for Biomechanics, ETH Zurich, 8952 Schlieren, Switzerland
Mol Biol Cell 16:1223-31. 2005..Our findings support the universality of the flow phenomenon and indicate that the maintenance of keratocyte shape during locomotion depends on the regulation of both retrograde flow and actin polymerization...
- Diffraction phase microscopy for quantifying cell structure and dynamicsGabriel Popescu
George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Opt Lett 31:775-7. 2006..The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells...
- Single particle analysis based on Zernike phase contrast transmission electron microscopyRadostin Danev
Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji cho, Okazaki, Aichi 444 8787, Japan
J Struct Biol 161:211-8. 2008..The same resolution, about 12A, was achieved by both imaging methods. The reconstruction based on Zernike phase contrast data required about 30% fewer particles. The advantages and prospects of each technique are discussed...
- Autofocusing in digital holographic phase contrast microscopy on pure phase objects for live cell imagingPatrik Langehanenberg
Center for Biomedical Optics and Photonics, University Medical Center of Muenster, Muenster, Germany
Appl Opt 47:D176-82. 2008....
- Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopyBjörn Kemper
University of Muenster, Laboratory of Biophysics, Robert Koch Str 45, D 48129 Muenster, Germany
J Biomed Opt 12:054009. 2007..Results obtained from human pancreas and liver tumor cells show that the integral cellular refractive index decreases with increasing cell radius...
- Phase contrast microscopy analysis of breast tissue: differences in benign vs. malignant epithelium and stromaWendy A Wells
Department of Pathology, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
Anal Quant Cytol Histol 31:197-207. 2009To assess how optical scatter properties in breast tissue, as measured by phase contrast microscopy and interpreted pathophysiologically, might be exploited as a diagnostic tool to differentiate cancer from benign tissue.
- Transmission electron microscopy with Zernike phase plateR Danev
National Institute for Physiological Sciences, Okazaki National Research Institutes, Japan
Ultramicroscopy 88:243-52. 2001..In order to make the technique user-friendly a number of improvements have to be made, and are discussed in terms of the current level of technology and instrumentation...
- Proliferative response of corneal endothelial cells from young and older donorsCheng Zhu
Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 45:1743-51. 2004....
- Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substratesN Q Balaban
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
Nat Cell Biol 3:466-72. 2001..The results put clear constraints on the possible molecular mechanisms for the mechanosensory response of focal adhesions to applied force...
- Spectral-domain phase microscopyMichael A Choma
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 30:1162-4. 2005..A shot-noise limit to the displacement sensitivity of this technique is derived. Measurement of cellular dynamics was performed on spontaneously beating cardiomyocytes isolated from chick embryos...
- Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imagingChulmin Joo
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Opt Lett 30:2131-3. 2005..We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells...
- Actin and septin ultrastructures at the budding yeast cell cortexAvital A Rodal
Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA 02454, USA
Mol Biol Cell 16:372-84. 2005..These images provide the first high-resolution views of septin organization in cells...
- Posterior capsule opacification-like changes in rat lens explants cultured with TGFbeta and FGF: effects of cell coverage and regional differencesJoel G Symonds
Discipline of Anatomy and Histology and Institute for Biomedical Research F13, University of Sydney, Sydney, NSW 2006, Australia
Exp Eye Res 82:693-9. 2006..Such overall resilience to variations in conditions may contribute to the insidious nature of PCO, while factors related to observed early differences between groups may contribute to PCO pleiomorphism...
- Two components of actin-based retrograde flow in sea urchin coelomocytesJ H Henson
Department of Biology, Dickinson College, Carlisle, Pennsylvania 17013, USA
Mol Biol Cell 10:4075-90. 1999..We propose a "push-pull" mechanism in which actin polymerization drives flow at the cell periphery, whereas myosin II provides the tension on the actin cytoskeleton necessary for flow in the cell interior...
- Synchrotron radiation in radiology: radiology techniques based on synchrotron sourcesReto Meuli
Service de radiodiagnostic et radiologie interventionnelle, CHUV, 1011 Lausanne, Switzerland
Eur Radiol 14:1550-60. 2004....
- Biometry of frozen-thawed sperm from eight breeds of Indian buffaloes (Bubalus bubalis)R A K Aggarwal
National Bureau of Animal Genetic Resources, Karnal, India
Theriogenology 68:682-6. 2007..Multivariate analysis and clustering put six breeds (Surti, Tarai, Mehsana, Jaffrabadi, Bhadawari and Nili-Ravi) in one cluster, whereas Murrah and Pandharpuri appeared as separate entities...
- Intact carboxysomes in a cyanobacterial cell visualized by hilbert differential contrast transmission electron microscopyYasuko Kaneko
Department of Biochemistry and Molecular Biology, Saitama University, 255 Shimo okubo, Sakura ku, Saitama 338 8570, Japan
J Bacteriol 188:805-8. 2006..The carboxysome was surrounded by a 5- to 6-nm-thick monolayer shell which consisted of orderly arrays of globular particles...
- Orientational order of the lamellipodial actin network as demonstrated in living motile cellsAlexander B Verkhovsky
Laboratory of Cell Biophysics and Biomechanics, Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland
Mol Biol Cell 14:4667-75. 2003..Here, we use an enhanced phase contrast microscopy technique to visualize an apparent long-range diagonal actin meshwork in the advancing lamellipodia of ..
- Field-based angle-resolved light-scattering study of single live cellsWonshik Choi
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Opt Lett 33:1596-8. 2008....
- In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord bloodKi Soo Park
Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health and BK21 Program for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
J Vet Sci 7:343-8. 2006..Therefore, it is suggested that the MSCs from UCB might be a good alternative to bone marrow cells for transplantation or cell therapy...
- A high-throughput microfluidic real-time gene expression living cell arrayKevin R King
Center for Engineering and Medicine and Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
Lab Chip 7:77-85. 2007..By enabling efficient investigation of dynamic gene expression programs, this technology has the potential to make significant impacts in basic science, drug development, and clinical medicine...
- Controlling mammalian cell interactions on patterned polyelectrolyte multilayer surfacesMichael C Berg
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Langmuir 20:1362-8. 2004..Finally, we found that pattern geometry affected cytoskeletal protein organization. Well-formed focal adhesions and cell-spanning stress fibers were only found in cells on wider line patterns (at least 25 microm in width)...
- Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathwayJu Eun Oh
Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Sciences, Dental Research Institute, and BK21 HLS, Seoul National University College of Dentistry, Seoul 110 749, Korea
J Biol Chem 280:21629-37. 2005..Lastly, it was observed that beta ig-h3-mediated keratinocyte differentiation was caused by promotion of cell adhesion and not by calcium regulation...
- Hemocyte-mediated phagocytosis and melanization in the mosquito Armigeres subalbatus following immune challenge by bacteriaJULIAN F HILLYER
Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Drive, Madison, WI 53706, USA
Cell Tissue Res 313:117-27. 2003..These studies implicate hemocytes as the primary line of defense against bacteria...
- Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by coculture with hepatic stellate cellsHirokazu Nagai
Department of Biochemistry, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
Biochem Biophys Res Commun 293:1420-5. 2002..Not only the extracellular matrices but also soluble factors, which are produced by hepatic stellate cells, induce this maturation, demonstrating the importance of the hepatic environment for hepatocyte differentiation...
- Platelet spherocytosis: a new bleeding disorderJames G White
Departments of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware Street SE, Mayo Mail Code 490, Minneapolis, MN 55455, USA
Am J Hematol 70:158-66. 2002..Differential interference phase contrast microscopy (DIC) revealed that his platelets were spherical in form...
- Differentiation of mouse embryonic stem cells into pancreatic and hepatic cellsGabriela Kania
In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research, Corrensstr 3, Gatersleben, D 06466, Germany
Methods Enzymol 365:287-303. 2003..Further, a histotypic "spinner" culture system was introduced to generate mature insulin- and albumin-producing cells at high efficiency...
- Endostatin induces autophagic cell death in EAhy926 human endothelial cellsY P Chau
Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
Histol Histopathol 18:715-26. 2003....
- Oogenesis in cultures derived from adult human ovariesAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
Reprod Biol Endocrinol 3:17. 2005..In addition, other clinical applications aiming to utilize stem cells, and basic stem cell research as well, may employ totipotent embryonic stem cells developing from fertilized oocytes...
- Establishment of a corneal epithelial cell line spontaneously derived from human limbal cellsJingbo Liu
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xian Lie Nan Road, Guangzhou, Guangdong 510060, China
Exp Eye Res 84:599-609. 2007..This cell line would be useful for studies of corneal epithelial biology and reconstructive corneal tissue engineering...
- Roles of ionotropic glutamate receptors in early developing neurons derived from the P19 mouse cell lineYi Hsuan Lee
Department of Physiology, Taipei Medical University, Taipei, Taiwan, ROC
J Biomed Sci 10:199-207. 2003..Therefore, AMPA and KA receptors might mediate neurotrophic functions to facilitate neurotrophic factor signaling to protect neurons against hypoxic insult in early neuronal development...
- Fibronectin fragments active in chondrocytic chondrolysis can be chemically cross-linked to the alpha5 integrin receptor subunitG A Homandberg
Department of Biochemistry, Rush Medical College at Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612 3864, USA
Osteoarthritis Cartilage 10:938-49. 2002....
- Stem cells (p63(+)) in keratinocyte cultures from human adult skinE Radu
Department of Cellular and Molecular Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
J Cell Mol Med 6:593-8. 2002..The main step was the selection of cells able to rapidly adhere to human collagen type IV in vitro. Thus, an increased proportion of putative ESC of about 65% was obtained, as demonstrated by p63 expression...
- Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilizationJesang Ko
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138 736, South Korea
Oncogene 22:4679-89. 2003..These results indicate that HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor...
- Interleukin-15 increases myosin accretion in human skeletal myogenic culturesPaul S Furmanczyk
University of Washington, School of Medicine, Seattle, WA 98195, USA
Cell Biol Int 27:845-51. 2003....
- Inhibition of the calcium- and voltage-dependent big conductance potassium channel ameliorates cisplatin-induced apoptosis in spiral ligament fibrocytes of the cochleaF Liang
Department of Pathology and Laboratory Medicine, 165 Ashley Avenue, Suite 309, PO Box 250908, Charleston, SC 29425, USA
Neuroscience 135:263-71. 2005..These findings also point to the calcium- and voltage-dependent big conductance potassium channels as a potential pharmacological target for manipulating cisplatin ototoxicity...
- G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodoniumRobin M Scaife
Laboratory for Cancer Medicine, West Australian Institute for Medical Research, Perth, Western Australia 6009, Australia
Mol Cancer Ther 3:1229-37. 2004..Hence, the antiproliferative activity of DPI reflects a novel inhibitory mechanism of cell cycle progression that can reverse spindle checkpoint-mediated cell cycle arrest...
- Cytoplasmic nuclear transfer of the actin-capping protein tropomodulinKimi Y Kong
Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 279:30856-64. 2004..These results suggest that, at least in myogenic cells, nuclear Tmod may be involved in the differentiation process...
- Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranesRyo Sudo
Center for Life Science and Technology, School of Fundamental Science and Technology, Keio University, Yokohama, Japan
FASEB J 19:1695-7. 2005..We conclude that highly differentiated 3D tissues, including functional BC, can be reconstructed by stacking up layers of SHs. This 3D stacked-up culture is useful for the reconstruction of tissue-engineered livers...
- Fibronectin and cell attachment to cell and protein resistant polyelectrolyte surfacesScott G Olenych
Department of Biological Science, The Florida State University, Tallahassee, Florida 32306, USA
Biomacromolecules 6:3252-8. 2005..Both cells and FN interacted much better with Nafion than with PAA-co-PAEDAPS in a micropatterned PEMU. These results indicate that A7r5 cell adhesion, spreading, and motility on PEMUs can be independent of FN binding to the surfaces...
- Plasmodium yoelii: axenic development of the parasite mosquito stagesJohanna M Porter-Kelley
Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Exp Parasitol 112:99-108. 2006..Our cell free system for development of the mosquito stages of P. yoelii provides a simplified approach to generate sporozoites that may be for biological assays and genetic manipulations...
- Enhanced neurite outgrowth by human neurons grown on solid three-dimensional scaffoldsM W Hayman
School of Biological and Biomedical Science, University of Durham, South Road, DH1 3LE, Durham, UK
Biochem Biophys Res Commun 314:483-8. 2004..These data suggest that the topography within the culture environment can significantly alter cell development and will therefore be an important feature when investigating the potential of human stem cells...
- Defined conditions for neural commitment and differentiationQi Long Ying
Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, Scotland, EH9 3JQ, UK
Methods Enzymol 365:327-41. 2003....
- Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and boneShinichiro Kume
Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume, Japan
J Bone Miner Res 20:1647-58. 2005....
- Phenotypic and functional characterization of adult brain neuropoiesisBjorn Scheffler
Departments of Neuroscience and Neurosurgery, University of Florida, McKnight Brain Institute, Gainesville, FL 32610, USA
Proc Natl Acad Sci U S A 102:9353-8. 2005....
- Bone nodule formation via in vitro differentiation of murine embryonic stem cellsSarah K Bronson
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Milton S Hershey Medical Center, H166, 500, University Drive, Hershey, Pennsylvania 17033 0850, USA
Methods Enzymol 365:241-51. 2003
- Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine productionSoonkyu Chung
Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina 27402 6170, USA
J Biol Chem 280:38445-56. 2005....
- Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout miceKarine Raymond
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cell Sci 118:1045-60. 2005..Our findings clearly demonstrate that, after birth, epidermal differentiation, proliferation and survival all proceed normally in the absence of alpha6beta4, provided that cell adhesion is not compromised...
- Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditionsL Egger
Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Zentrale Klinische Forschung, Breisacherstrasse 66, D 79106 Freiburg, Germany
Cell Death Differ 10:1188-203. 2003..Thus, despite caspase inhibition or basal caspase activities, cells can still be phagocytosed and killed in an apoptosis-like fashion by a serine protease-mediated mechanism that damages the mitochondrial membrane...
- Microfabricated embryonic stem cell divider for large-scale propagation of human embryonic stem cellsMinseok S Kim
Department of Biosystems, Korea Advanced Institute of Science and Technology KAIST, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
Lab Chip 7:513-5. 2007..The ESCD will contribute to the advance quality control of in vitro ESC cultures and allow large-scale production of qualified ESCs with tremendous time- and work-saving...
- Analysis of leukocyte migration through monolayers of cultured endothelial cellsHelen M McGettrick
Division of Medical Sciences, Department of Physiology, The Medical School, The University of Birmingham, Birmingham, UK
Methods Mol Biol 370:37-54. 2007..In general, the filter-based assay has the highest throughput and greatest ease of use but yields less detailed information, whereas the flow-based assay is most difficult to set up but is most physiologically relevant...
- Ep-CAM transfection in thymic epithelial cell lines triggers the formation of dynamic actin-rich protrusions involved in the organization of epithelial cell layersJ C Guillemot
CNRS LNB, , Chemin de J Aiguier, Marseille 13009, France
Histochem Cell Biol 116:371-8. 2001..These results suggest that expression of Ep-CAM might balance the organizing capacity of cadherin molecules and may be participating in the formation of a dynamic stromal cell network in the thymus...
- Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentumHilary A Kenny
Department of Obstetrics and Gynecology Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA
Int J Cancer 121:1463-72. 2007....
- Thyroid hormone regulates the expression of alpha-internexin in neurons in cultureDavid Sampson
Division of Molecular Endocrinology, University College London Medical School, Mortimer Street, London W1N 8AA, UK
Neuroreport 13:273-6. 2002..This supports the hypothesis that maternal thyroid hormone directly regulates early neuronal differentiation...
- Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesisJ Qiao
Department of Medicine, VASD HS and Cancer Center, University of California, San Diego, CA 92093 0693, USA
Mech Dev 109:123-35. 2001....
- Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survivalR W Johnstone
The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Cancer Immunology Division, East Melbourne, 3002 Victoria, Australia
Mol Cell Biol 21:1672-81. 2001..These novel results indicate that ELL can regulate cell growth and survival and may explain how ELL translocations result in the development of human malignancies...
- The role of surface wettability on hepatocyte adhesive interactions and functionN Krasteva
Institute of Biophysics, Bulgarian Academy of Sciences, Sofia
J Biomater Sci Polym Ed 12:613-27. 2001..It was concluded that the wettability of materials has a strong influence on the attachment and morphology of hepatocytes while the influence of surface properties on the functional activity of hepatocytes still remains to be elucidated...
- Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophagesF J Pixley
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Cell Biol 21:1795-809. 2001....
- Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signalingChristophe F Deroanne
Research Center in Experimental Cancerology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
Oncogene 21:427-36. 2002..These observations provide a conspicuous demonstration that HDAC inhibitors are potent anti-angiogenic factors altering VEGF signaling...
- Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cellsE H Javazon
Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Stem Cells 19:219-25. 2001..The rat mMSCs differed from human mMSCs in that they regenerated RS cells in culture. Also, after low-density plating, colonies of rMSCs expanded into confluent cultures, whereas colonies of hMSCs did not...
- Protein kinase C alpha and gamma in N/N 1003A rabbit lens epithelial cell differentiationL M Wagner
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
Mol Vis 7:57-62. 2001..METHODS: PKCalpha or PKCgamma was overexpressed in N/N 1003A lens epithelial cells for up to 7 days. Phase contrast microscopy was used to observe morphological changes associated with PKCalpha or PKCgamma overexpression...
- The characterisation of human respiratory epithelial cells cultured on resorbable scaffolds: first steps towards a tissue engineered tracheal replacementBrian W Ziegelaar
Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich, Germany
Biomaterials 23:1425-38. 2002..Furthermore, that UEA and PNA staining is a useful tool in the characterisation of cells cultured on biomaterials, therefore helpful in identifying biomaterials that are suitable for specific tissue engineering purposes...
- Liver sinusoidal endothelial cells are the principal site for elimination of unfractionated heparin from the circulationCristina Ionica Oie
Center for Atherothrombotic Research in Tromsø, Department of Medicine, Institute of Clinical Medicine, University of Tromsø, N 9037 Tromsø, Norway
Am J Physiol Gastrointest Liver Physiol 294:G520-8. 2008..The results suggest a major role for LSECs in heparin elimination...
- Rickettsia rickettsii infection causes apoptotic death of cultured cerebellar granule neuronsSuresh G Joshi
J Med Microbiol 56:138-41. 2007
- C2-ceramide as a cell death inducer in HC11 mouse mammary epithelial cellsSung Hak Kim
Department of Animal Science and Technology, School of Agricultural Biotechnology, Seoul National University, Suweon 441 744, South Korea
Cancer Lett 203:191-7. 2004....
- Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cellsGuang Zhen Jin
Division of Applied Life Science, Gyeongsang National University, Jinju 660 701, Korea
J Vet Sci 8:377-82. 2007..Thus, the MSCs of feline bone marrow can up-regulate TH expression in PC12 cells. This implies a new role for MSCs in the neurodegenerative disease process...
- In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6RRonald E Unger
Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
Microvasc Res 64:384-97. 2002..Thus, HPMEC-ST1.6R will be a valuable in vitro model system in which to study pathomechanisms and angiogenesis of the mature microvascular endothelium in vitro...
- Neural cell differentiation from retinal pigment epithelial cells of the newt: an organ culture model for the urodele retinal regenerationYoko Ikegami
Developmental Neurobiology Laboratory, Department of Biological Sciences, Faculty of Science, Nara Women s University, Nara 630 8506, Japan
J Neurobiol 50:209-20. 2002....
- Hepatic differentiation of mouse ES cells into BE cells in vitroAn Bin Hu
Organ Transplantation Center, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, China
Cell Biol Int 30:459-65. 2006..4% on day 21. ES cells were found to be able to differentiate into BE cells when cultured using medium with appropriate cell growth factors. These BE cells may be a novel source of differentiated cell types for liver engineering...
- Protein kinase C-mediated cell death mode switch induced by high glucoseR Fujita
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Cell Death Differ 10:1336-47. 2003..All these results suggest that high-glucose treatment causes neuronal cell death mode switch by inhibiting necrosis, while inducing apoptosis, which is prevented by neurotrophic factors...
- Upregulation of heat shock protein expression by proteasome inhibition: an antiapoptotic mechanism in the lensNiranjan Awasthi
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, Newark, 07101, USA
Invest Ophthalmol Vis Sci 46:2082-91. 2005..The present study was conducted to test the hypothesis that proteasome inhibition can protect lens cells against apoptosis by upregulating heat shock protein (HSP) expression...
- Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiationLiping Sun
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 280:26448-56. 2005....
- The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanismE Erbay
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
J Biol Chem 276:36079-82. 2001..Taken together, our observations suggest a novel mTOR signaling mechanism essential for skeletal muscle differentiation...
- Primary culture of medaka (Oryzias latipes) testis: a test system for the analysis of cell proliferation and differentiationMiyeoun Song
Institute of Zoology, TU Dresden, Mommsenstrasse 13, 01062, Dresden, Germany
Cell Tissue Res 313:107-15. 2003..The test system is suitable for the study of the effect of substances which interfere with spermatogenesis in the vertebrate medaka model...
- Dictyostelium discoideum talin A is crucial for myosin II-independent and adhesion-dependent cytokinesisMakoto Hibi
Graduate School of Science, Hokkaido University, Sapporo, Hokkaido 060 0810, Japan
J Muscle Res Cell Motil 25:127-40. 2004....
- Centrosome-dependent exit of cytokinesis in animal cellsM Piel
Institut Curie, Section Recherche, UMR 144 du CNRS, 26 rue d'Ulm, 75248 Paris Cedex 05, France
Science 291:1550-3. 2001....
- Engineering cell de-adhesion dynamics on thermoresponsive poly(N-isopropylacrylamide)Beiyi Chen
Center of Biotechnology, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 639798, Singapore
Acta Biomater 4:218-29. 2008..Furthermore, immunostaining of actin provides supporting evidence that the de-adhesion kinetics is correlated with the cytoskeleton transformation during cell de-adhesion below the lower solution critical temperature (LCST)...
- A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral typeD Wayne Berman
Aeolus, Inc, Albany, California 94706 1026, USA
Crit Rev Toxicol 38:49-73. 2008..If similar data become available for Quebec, perhaps these two size distributions can be used to eliminate the discrepancy between these two studies...
- Carbon source-dependent regulation of cell growth by murine protein kinase C epsilon expression in Saccharomyces cerevisiaeA M Parissenti
Department of Research, Northeastern Ontario Regional Cancer Centre, Sudbury, Canada
J Cell Physiol 178:216-26. 1999..Visualization of the cells by phase contrast microscopy indicated that murine PKCepsilon expression in the presence of glycerol resulted in a significant ..
- Retained functional integrity of bull spermatozoa after double freezing and thawing using PureSperm density gradient centrifugationW M C Maxwell
Faculty of Veterinary Science, University of Sydney, Sydney, Australia
Reprod Domest Anim 42:489-94. 2007..spermatozoa was significantly improved by selection through the PureSperm gradient, whether measured by phase contrast microscopy (78.9 +/- 9.7 vs 90.4 +/- 4.0% NAR, p < 0.05) or flow cytometry (53.4 +/- 11.7 vs 76.3 +/- 6...
- Immunological and ultrastructural characterization of endothelial cell cultures differentiated from human cord blood derived endothelial progenitor cellsJosef Neumüller
Center for Anatomy and Cell Biology, Department of Cell Biology and Ultrastructure Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Histochem Cell Biol 126:649-64. 2006..We characterized both cell populations by flow cytometry, phase contrast microscopy, fluorescence microscopy and confocal laser scanning microscopy as well as ultrastructurally using ..
- Effects of 5-fluouracil combined with sulfasalazine on human pancreatic carcinoma cell line BxPC-3 proliferation and apoptosis in vitroZhe Huang
Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China
Hepatobiliary Pancreat Dis Int 6:312-20. 2007....
- Protein kinase C modulator effects on parathyroid hormone-induced intracellular calcium and morphologic changes in UMR 106-H5 osteoblastic cellsM Babich
University of Illinois College of Medicine, Rockford, Illinois 61107 1897, USA
J Cell Biochem 65:276-85. 1997..The data suggest PKC contributes to UMR 106-H5 cell morphology and selectively regulates signal pathways activated by PTH to promote either cell contraction (cAMP) or extension (1,4,5-IP3/Cai2+)...
- Differentiated cellular function in fetal chondrocytes cultured with insulin-like growth factor-I and transforming growth factor-betaA J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 16:531-41. 1998....
- Exposure to chrysotile asbestos associated with unpacking and repacking boxes of automobile brake pads and shoesA K Madl
ChemRisk, Inc, 25 Jessie Street, Suite 1800, San Francisco, CA 94105, USA
Ann Occup Hyg 52:463-79. 2008..collected during the unpacking and repacking of boxes of asbestos-containing brakes were analyzed by phase contrast microscopy and transmission electron microscopy...
- Inhibition of plasminogen activators attenuates the death of differentiated retinal ganglion cells and stabilizes their neurite network in vitroRonée Harvey
Eye Research Institute of Oakland University, Rochester, MI 48309, USA
Invest Ophthalmol Vis Sci 48:1884-91. 2007....
- A study of airborne chrysotile concentrations associated with handling, unpacking, and repacking boxes of automobile clutch discsGeorge C T Jiang
ChemRisk, Inc, 25 Jessie Street, Suite 1800, San Francisco, CA 94105, USA
Regul Toxicol Pharmacol 51:87-97. 2008..boxes of asbestos-containing clutches, and the subsequent cleanup and clothes handling, were analyzed by phase contrast microscopy (PCM) and transmission electron microscopy (TEM)...
- Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cellsSwarajit K Biswas
Department of Medicine, Penn State Hershey Heart and Vascular Institute, Penn State College of Medicine, Hershey, PA 17033, USA
Mol Vis 15:1599-610. 2009..In the present study, we tested the hypothesis that the pro-survival effect of insulin-induced PI 3-kinase/Akt signaling is compromised by imatinib inhibition of PDGF receptor signaling in RGCs...
- Fibroblast growth factor 2 regulation of mitral valve interstitial cell repair in vitroAvrum I Gotlieb
Vascular Research Laboratory, Toronto General Hospital, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 124:591-7. 2002..We characterized the cellular morphology and pattern of repair of these interstitial cells in wounds produced in vitro and tested the hypothesis that fibroblast growth factor 2 enhances interstitial cell repair...
- Effect of an essential oil-containing dentifrice on dental plaque microbial compositionC H Charles
The Warner Lambert Consumer Healthcare Division of the Warner Lambert Consumer Group of Pfizer, Morris Plains, NJ 07950, USA
Am J Dent 13:26C-30C. 2000....
- In vitro induction of the acrosome reaction in ovine spermatozoa by calcium ionophore A23187O Ucar
Department of Clinical Veterinary Sciences, Bristol University, Bristol, United Kingdom
Acta Vet Hung 51:103-9. 2003..After fixing in 10% formaldehyde, the number of spermatozoa that had undergone AR was determined by phase contrast microscopy. In pre-incubation samples, 21.3 +/- 3.3% of spermatozoa had undergone AR...
- Development and application of different methods for the detection of Toxoplasma gondii in waterChristina Kourenti
Institute for Medical Parasitology, Medical Faculty, University of Bonn, 53127 Bonn, Germany
Appl Environ Microbiol 69:102-6. 2003..This is the first step in developing a systematic approach for the detection of Toxoplasma oocysts in water...
- SPERM FUNCTION IN FERTILIZATION EVENTSGary Olson; Fiscal Year: 2006..3: To determine if eFGL binding to specific sperm ligands promotes sperm death and/or death cocoon polymerization.4: To define the function of eFGL by targeted disruption of the fgl2 gene in mice. ..
- Local Tomography for Radiation Therapy Tumor ImagingMARK ANASTASIO; Fiscal Year: 2005..By increasing the conformality of the radiation therapy treatment procedure, the chances of survival for cancer patients could be improved while simultaneously minimizing the risk of radiation-induced complications. ..
- Functional Analysis of Mitotic Checkpoint Gene Bub1bRakesh Goorha; Fiscal Year: 2005..These studies are expected to establish the functions of Bub1b during mitosis and cytokinesis. ..
- CYTOMIMETIC ORGANIC CHEMISTRYFREDRIC MENGER; Fiscal Year: 2007....
- Regulation of Arp2/3 complex Y-branch dynamicsERIN LYNN BENANTI; Fiscal Year: 2012..Quantitative fluorescence microscopy (qFSM) and phase contrast microscopy will be used to analyze lamellipodia dynamics in cells containing mutant Arp2/3 complexes...
- Fourier Phase Contrast Microscopy Technique for Biomedical ResearchDEVULAPALLI V RAO; Fiscal Year: 2010..Recently we demonstrated the principle of a novel user-friendly Fourier phase contrast microscopy (FPCM) technique with potential for enhanced performance exploiting monochromaticity and phase coherence ..
- DEVELOPMENT OF A COMPUTER-ASSISTED ASSAY OF CELL MOTIONElliot Goldstein; Fiscal Year: 1991..Cellular orientation, chemokinesis and chemotaxis are measured by phase contrast microscopy throughout the six minute period except for the three ten second intervals...
- Role of Selenoprotein P in Male FertilityGary Olson; Fiscal Year: 2007..unreadable] Aim 3: To identify and localize Se-P-binding proteins in the testis and epididymis. [unreadable] Aim 4: To determine the molecular basis for sperm defects in Se-P null mice. [unreadable] [unreadable]..
- SURVEILLANCE METHODS FOR HEALTH CARE AND RELATED WORKERSJohn Dement; Fiscal Year: 2004..Results of the case-based surveillance effort also will have broad application to health care workers. ..
- Phase-Contrast Imaging of Microvascular StuctureMARK ANASTASIO; Fiscal Year: 2006..The successful completion of our proposed research will establish in-line phase-contrast tomography as an effective and important modality for imaging microvascular structure. [unreadable] [unreadable]..
- Development of gene transfer approaches for neuroAIDSYuanan Lu; Fiscal Year: 2006..Overall, the work is expected to result in significant insight into new approaches for treatment of neuroAIDS and other neurologic diseases. ..
- Amplification of TRIAL-Indcued Apoptosis in MesotheliomaV Broaddus; Fiscal Year: 2006..the mechanisms of amplification of TRAIL-induced apoptosis can provide insight into the means by which malignant cells evade apoptosis and ways to bypass those sites of resistance and thereby improve treatment strategies ..
- Ketone Dysregulation and Muscle Insulin ResistanceDEBORAH MUOIO; Fiscal Year: 2006..abstract_text> ..
- Protein Kinase G Regulation of Granulosa Cell ViabilityJohn Peluso; Fiscal Year: 2006..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
- Progesterone regulation of human luteal cell viabilityJohn Peluso; Fiscal Year: 2006..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
- Changes in the Cornified Cell Envelope in HPV InfectionDarron Brown; Fiscal Year: 2006..abstract_text> ..
- SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATADavid Soll; Fiscal Year: 2006..abstract_text> ..
- Gene Expression in Alzheimer's DiseaseWalter Lukiw; Fiscal Year: 2006..abstract_text> ..
- Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistanceDeborah M Muoio; Fiscal Year: 2010....
- Matrix metalloproteinases as biomarkers of neurodegenerationVeronica Shubayev; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Dendritic Cells in Salivary Mucosal Immune ResponsesNANCY O SULLIVAN; Fiscal Year: 2008..abstract_text> ..
- Center for Childhood Asthma in the Urban EnvironmentPatrick Breysse; Fiscal Year: 2008..abstract_text> ..
- Photothermal Imaging of Live CellsVladimir Zharov; Fiscal Year: 2008..The technical realization of PTI is relatively simple, requiring the combination of conventional optical phase-contrast microscopy and the already routinely used nanosecond laser. ..
- CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLEMichael Sanderson; Fiscal Year: 2002..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
- Effect of Glutamine on HSP-70 Expression in ICU patientsPaul Wischmeyer; Fiscal Year: 2007..The potential for such an agent to reduce morbidity/mortality in surgical and critical illness is significant. [unreadable] [unreadable]..
- Calcium signaling in airway smooth muscle in lung slicesMichael Sanderson; Fiscal Year: 2007..abstract_text> ..
- Identifying human genes required by tick-borne pathogensUlrike Munderloh; Fiscal Year: 2007..We anticipate that the interaction of the human host cells with these highly specialized intracellular pathogens will shed light,on the nature of some unidentified human genes. [unreadable] [unreadable] [unreadable]..
- Glutamine's role in cardioprotection from cardiac bypassPaul Wischmeyer; Fiscal Year: 2007..Data will be collected on cardiac function (cardiac output), occurrence of arrhythmias, need for vasopressor therapy, length of post-operative ventilation, ICU stay; and survival trends. ..
- Mucosal immune response to oral cholera vaccine Peru 15Firdausi Qadri; Fiscal Year: 2007..cholerae. ..
- Integrated Photothermal NanoprobesVladimir Zharov; Fiscal Year: 2007..The results of these studies will also make it possible to formulate recommendations on the desired properties of new, clustered nanomaterials for medical applications. [unreadable] [unreadable] [unreadable]..
- Effect of Previous Irradiation on Brain Tumor Growth and Response to TherapyGLENN GOBBEL; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Pre-habilitation of Aged and Young Neuromuscular SystemsMICHAEL DESCHENES; Fiscal Year: 2005....
- Dynamics and Noise in a Genetic Network LibraryJOHN CHUANG; Fiscal Year: 2005..Finally, since fluctuations in the concentration of components can lead to population heterogeneity, single cell analysis of network dynamics in response to time-varying inputs will be performed. ..
- Guided Pocket Recolonization (GPR) in PeriodontitisMarc Quirynen; Fiscal Year: 2004..Clinical data will be collected after 2, 4, 6, 8 and 12 weeks. The results should indicate the possible role for commensal organisms in periodontal disease and subgingival biofilm formation. ..
- Cathepsin B in Progression of Prostatic Lesion to CancerAKHOURI SINHA; Fiscal Year: 2004....
- Nanoparticle delivery of antiangiogenic genesGerard Lutty; Fiscal Year: 2003..The goal of this proposal is to deliver genes for endogenous antiangiogenic agents to sites of ocular neovascularization. ..
- Adeno-associated virus for IGF-I cartilage gene therapyAlan Nixon; Fiscal Year: 2003..abstract_text> ..
- Cytoxicity and Solubility of Beryllium ParticlesPatrick Breysse; Fiscal Year: 2002..abstract_text> ..
- MONOCYTE/MACROPHAGE SUBCELLULAR LIPOPROTEIN PROCESSINGNancy Jones; Fiscal Year: 2002..The role of receptors and non-specific binding will be determined by competition studies. The proposed studies will provide potential mechanism(s) for native LDL to cause in vitro foam cell formation. ..
- MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESISABRAHAM KIERSZENBAUM; Fiscal Year: 2002..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..
- EICOSANOIDS AND PULMONARY VASCULAR TONESANDRA PFISTER; Fiscal Year: 2002....
- PULMONARY ADAPTIVE RESPONSES AND CADMIUM CARCINOGENESISBETH HART; Fiscal Year: 2001....
- PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURYV Broaddus; Fiscal Year: 2001..These studies should provide important information about the mechanisms by which asbestos induces apoptosis in mesothelial cells and the role of asbestos-induced apoptosis in asbestos-induced pathology. ..
- PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSISUlrike Munderloh; Fiscal Year: 2001....
- Photothermal Evaluation of Drug Toxicity at Cell LevelVladimir Zharov; Fiscal Year: 2004..abstract_text> ..
- Podocyte Protein Alterations Induced by GlucocorticoidsRichard Ransom; Fiscal Year: 2005..Identification of a potential mechanism for glucocorticoid action in the treatment of NS would permit the development of more highly targeted and less toxic therapies for this very common form of kidney disease. ..
- PR3-ANCA Subsets and Disease PhenotypeUlrich Specks; Fiscal Year: 2005..This study will provide new insights into the potential pathogenic role of PR3-ANCA that are not obtainable in any other way, and will constitute the most definitive study of these antibodies to date. ..
- The regulation of airway ciliary activityMichael Sanderson; Fiscal Year: 2005..abstract_text> ..
- Switching and Candida Pathogenesis-A Molecular AnalysisDavid Soll; Fiscal Year: 2005..The first three aims have been formulated so that they provide several independent starting points for a reverse genetic approach for elucidating switch loci and the switching mechanism. ..
- Novel Single Cell Reporter Gene AssayYevgenya Akselband; Fiscal Year: 2005..This assay will facilitate drug discovery by permitting rapid screening of combinatorial chemistry or natural product libraries. ..
- MECHANISM AND REGULATION OF ACTIN-BASED RETROGRADE FLOWJOHN HENSON; Fiscal Year: 2005..4. To study the inducible transformation of coelomocytes from a lamellipodial to a filopodial form. ..
- Integrated optical imaging rat of mesenteryVladimir Zharov; Fiscal Year: 2004..The technical realization of this new imaging system is relatively simple, combining transmission microscopy and laser technique already routinely in use. ..
- Novel anti-HIV carrageenan-based on microbicidesDavid Phillips; Fiscal Year: 2004..The applicant believes that the proposed research will result in the pre-clinical development of a safe, novel microbicide that is superior in efficacy against HIV. ..
- Multifunctional Microscopy for Structural BiologyGuy Indebetouw; Fiscal Year: 2004..abstract_text> ..
- Regulation of Oocyte Viability by Granulosa Cell ContactJohn Peluso; Fiscal Year: 2004..abstract_text> ..
- PROLACTIN AND ENDOTHELIAL WOUND REPAIR IN VITROCARRIE MERKLE; Fiscal Year: 2001..State-of-the-art imaging techniques, including light microscopy and electron microscopy, and biochemical methods, e.g. the polymerase chain reaction and Western blot analysis, will be employed. ..
- Role of Rho Kinase in Aqueous Humor Outflow PathwayP Rao; Fiscal Year: 2004..Identification of specific signaling mechanisms regulating function of outflow pathway tissues could enable the design of target-specific approaches to the treatment of glaucoma. ..
- Technology Development in Optical Coherence TomographyEmily McDowell; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..