manometry

Summary

Summary: Measurement of the pressure or tension of liquids or gases with a manometer.

Top Publications

  1. ncbi Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    Jeffrey T Kuvin
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 146:168-74. 2003
  2. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
  3. ncbi Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction
    Eiichi Akiyama
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 60:1778-86. 2012
  4. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
  5. pmc Assessment of endothelial function using digital pulse amplitude tonometry
    Naomi M Hamburg
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Cardiovasc Med 19:6-11. 2009
  6. ncbi Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?
    Gerrit J M Hemmink
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 103:2446-53. 2008
  7. pmc Randomized controlled trial shows biofeedback to be superior to pelvic floor exercises for fecal incontinence
    Steve Heymen
    Department of Medicine Division of Gastroenterology and Hepatology and Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Dis Colon Rectum 52:1730-7. 2009
  8. ncbi Anorectal functional testing: review of collective experience
    Fernando Azpiroz
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Am J Gastroenterol 97:232-40. 2002
  9. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
  10. ncbi Perception of dysphagia: lack of correlation with objective measurements of esophageal function
    A Lazarescu
    Centre for Gastroenterological Research, KU Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:1292-7, e336-7. 2010

Research Grants

  1. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
  2. Planning Grant for SOD III Multicenter Trial
    Peter Cotton; Fiscal Year: 2004
  3. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
  4. High-Definition Manometry: A Novel Diagnostic Tool
    Thomas Parks; Fiscal Year: 2006
  5. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
  6. Gastroesophageal Antireflux Mechanisms
    MICHAEL RAYMOND RUGGIERI; Fiscal Year: 2013
  7. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
  8. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2013
  9. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2013
  10. The Role of Lung Volumes in Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2010

Detail Information

Publications331 found, 100 shown here

  1. ncbi Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    Jeffrey T Kuvin
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 146:168-74. 2003
    ..We evaluated the relationship between changes in PWA of the finger and peripheral endothelial function...
  2. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
    ..We examined whether endothelial dysfunction, as detected by non-invasive peripheral arterial tonometry (EndoPAT), can predict late CV events...
  3. ncbi Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction
    Eiichi Akiyama
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 60:1778-86. 2012
    ..The purpose of this study was to investigate whether peripheral endothelial dysfunction could predict the occurrence of cardiovascular events in patients with heart failure (HF) with normal left ventricular ejection fraction (HFNEF)...
  4. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..junction (EGJ) relaxation and aperistalsis, 3 distinct patterns of aperistalsis are discernable with high-resolution manometry (HRM). This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes.
  5. pmc Assessment of endothelial function using digital pulse amplitude tonometry
    Naomi M Hamburg
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Cardiovasc Med 19:6-11. 2009
    ..This article reviews the recent studies that support the utility of digital pulse amplitude tonometry as a relevant test of peripheral endothelial function...
  6. ncbi Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?
    Gerrit J M Hemmink
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 103:2446-53. 2008
    ..Until now, it is unclear whether combined pH-impedance monitoring in these patients should be performed on or off PPI...
  7. pmc Randomized controlled trial shows biofeedback to be superior to pelvic floor exercises for fecal incontinence
    Steve Heymen
    Department of Medicine Division of Gastroenterology and Hepatology and Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Dis Colon Rectum 52:1730-7. 2009
    ..This study aimed to compare manometric biofeedback with pelvic floor exercises for the treatment of fecal incontinence in a randomized controlled trial controlling for nonspecific treatment effects...
  8. ncbi Anorectal functional testing: review of collective experience
    Fernando Azpiroz
    Digestive System Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Am J Gastroenterol 97:232-40. 2002
    Anorectal manometry includes a number of specific tests that are helpful in the diagnostic assessment of patients with fecal incontinence and constipation; their purpose is to delineate the pathophysiological mechanism for these symptoms...
  9. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
    ..The secondary objective was to evaluate the effect of atracurium on pharyngeal function...
  10. ncbi Perception of dysphagia: lack of correlation with objective measurements of esophageal function
    A Lazarescu
    Centre for Gastroenterological Research, KU Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:1292-7, e336-7. 2010
    ..A correlation between the intensity of the symptom and the severity of esophageal dysfunction, either motility (manometry) or bolus transit (impedance) has not been clearly demonstrated...
  11. ncbi Use of manometry for laryngeal mask airway reduces postoperative pharyngolaryngeal adverse events: a prospective, randomized trial
    Edwin Seet
    Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 112:652-7. 2010
    Adverse events such as pharyngolaryngeal complications are indicators of quality patient care. Use of manometry to limit the laryngeal mask airway (LMA) intracuff pressure is not currently a routine practice...
  12. pmc Relevance of ineffective oesophageal motility during oesophageal acid clearance
    M Simren
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Gut 52:784-90. 2003
    ..Intraluminal impedance allows non-radiological monitoring of movement of oesophageal liquids...
  13. ncbi Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device
    Paolo Salvi
    Department of Internal Medicine, Bufalini Hospital, Cesena, Italy
    J Hypertens 22:2285-93. 2004
    ..Its software provides absolute arterial pressure values, an assessment of arterial pulse wave contours, an estimation of reflection waves and measurements of PWV...
  14. pmc Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans
    Alban Redheuil
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Hypertension 55:319-26. 2010
    ..In particular, compared with other measures of aortic function, the best markers of subclinical large artery stiffening, were AA distensibility in younger and aortic arch pulse wave velocity in older individuals...
  15. ncbi High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry
    M Fox
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
    Neurogastroenterol Motil 16:533-42. 2004
    High-resolution manometry (HRM) is a recent development in oesophageal measurement; its value in the clinical setting remains a matter of controversy...
  16. ncbi Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise
    James E Sharman
    Department of Medicine, School of Human Movement Studies, University of Queensland, Princess Alexandra Hospital, Queensland, Australia
    Hypertension 47:1203-8. 2006
    ..001). True myocardial afterload is not reliably estimated by peripheral systolic BP. Radial tonometry and pulse wave analysis is an accurate technique for the noninvasive determination of central BP at rest and during exercise...
  17. ncbi Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea
    Malcolm Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Am J Respir Crit Care Med 178:984-8. 2008
    ..Moderate-severe obstructive sleep apnea (OSA) is associated with endothelial dysfunction, increased arterial stiffness, and hypertension. It is not known whether minimally symptomatic OSA is also associated with impaired vascular function...
  18. ncbi 24-h esophageal pH testing in asthmatics: respiratory symptom correlation with esophageal acid events
    S M Harding
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Chest 115:654-9. 1999
    ..This study examines the prevalence and severity of GER in asthmatics with and without reflux symptoms and examines respiratory symptom correlation with esophageal acid...
  19. ncbi Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry
    John E Pandolfino
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 131:1725-33. 2006
    ..was to perform a detailed analysis of the mechanics leading to esophagogastric junction (EGJ) opening during transient lower esophageal sphincter relaxations (tLESRs) using high-resolution manometry coupled with simultaneous fluoroscopy.
  20. ncbi Variability of peripheral arterial tonometry in the measurement of endothelial function in healthy men
    Jianmin Liu
    Research Development and Engineering, Altria Client Services, Richmond, Virginia
    Clin Cardiol 32:700-4. 2009
    ..The interday reproducibility is relatively low and the intrasubject variability of RHI is similar to those observed in studies of flow-mediated dilation using brachial artery ultrasound scanning...
  21. ncbi Endotracheal tube cuff pressures in pediatric patients intubated before aeromedical transport
    William W Tollefsen
    Harvard Affiliated Emergency Medicine, Brigham and Women s Hospital Massachusetts General Hospital, 75 Francis St, Neville House 236A, Boston, MA 02115, USA
    Pediatr Emerg Care 26:361-3. 2010
    ....
  22. ncbi Anorectal physiology in relation to clinical subgroups of patients with severe constipation
    U Karlbom
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    Colorectal Dis 6:343-9. 2004
    ..The aim of this study was to evaluate anorectal physiology in relation to clinically defined subgroups of patients with idiopathic constipation and to analyse relationships between anorectal physiology and rectal evacuation...
  23. ncbi Augmentation index relates to progression of aortic disease in adults with Marfan syndrome
    Kai Mortensen
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Am J Hypertens 22:971-9. 2009
    ..Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS)...
  24. pmc Advances in diagnostic assessment of fecal incontinence and dyssynergic defecation
    Satish S C Rao
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Clin Gastroenterol Hepatol 8:910-9. 2010
    ..has emerged over the past decade that includes the development of newer diagnostic tools such as high-resolution manometry and magnetic resonance defecography as well as a better delineation of the clinical and pathophysiologic ..
  25. ncbi Reproducibility of peripheral arterial tonometry for the assessment of endothelial function in adults
    Luísa C C Brant
    aBrazilian Longitudinal Study of Adult Health, ELSA Brasil bHospital das Clínicas and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Hypertens 31:1984-90. 2013
    ..However, there is a paucity of data about its reproducibility. The aim of this study was to assess the feasibility and reproducibility of PAT in adults...
  26. ncbi Multicentre retrospective analysis of the outcome of artificial anal sphincter implantation for severe faecal incontinence
    D F Altomare
    Department of General Surgery and Liver Transplantation, University of Bari, Italy
    Br J Surg 88:1481-6. 2001
    ..A new prosthetic device, the Action artificial anal sphincter, has recently been introduced for treating severe faecal incontinence. The results of this procedure in 28 patients are presented...
  27. ncbi Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study
    T G Liman
    Charite Universitatsmedizin Berlin, Germany
    Cephalalgia 32:459-66. 2012
    ..Here, we investigated whether systemic endothelial function and arterial stiffness are altered in women with MA, using a novel peripheral arterial tonometry device for the first time...
  28. ncbi Clinical impact of gastric exercise tonometry on diagnosis and management of chronic gastrointestinal ischemia
    Johannes A Otte
    Department of Internal Medicine and Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands
    Clin Gastroenterol Hepatol 3:660-6. 2005
    ..This study evaluates the diagnostic accuracy and clinical impact of gastric tonometry during exercise (GET) in a patient cohort suspected of chronic splanchnic syndrome...
  29. pmc Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography
    A J Bredenoord
    Department of Gastroenterology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Neurogastroenterol Motil 24:57-65. 2012
    ..has been an evolutionary process, molded first by published evidence pertinent to the clinical interpretation of high resolution manometry (HRM) studies and secondarily by group experience when suitable evidence is lacking.
  30. ncbi Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes
    Junichi Matsubara
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, and Department of Cardiovascular Clinical and Translational Research, Kumamoto University Hospital, Kumamoto, Japan
    Circ J 77:1337-44. 2013
    ..Dipeptidyl peptidase 4 (DPP4) inhibitors are used for treatment of diabetes mellitus (DM). We hypothesized that sitagliptin, a DPP4-inhibitor, could improve endothelial dysfunction in DM patients with coronary artery disease (CAD)...
  31. ncbi Long-term outcome and objective changes of anorectal function after biofeedback therapy for faecal incontinence
    R Ozturk
    Department of Internal Medicine, Section of Neurogastroenterology, Division of Gastroenterology Hepatology, University of Iowa Carver College of Medicine, Iowa City, USA
    Aliment Pharmacol Ther 20:667-74. 2004
    ..In the short-term, biofeedback therapy improves symptoms and anorectal function in patients with faecal incontinence but whether there is long-term improvement is incompletely understood...
  32. ncbi Tonometric arterial pulse sensor with noise cancellation
    Edward J Ciaccio
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    IEEE Trans Biomed Eng 55:2388-96. 2008
    ..Adaptive weighting provides better cancellation than fixed weighting, likely because the mechanical gain at the transducer-skin interface is time-varying...
  33. ncbi Clinical utility of colonic and anorectal manometry in chronic constipation
    Satish S C Rao
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Gastroenterol 44:597-609. 2010
    ..Colonic manometry with sensation and tone assessment (barostat) and anorectal manometry with rectal sensation and compliance ..
  34. ncbi Long-term study on the effects of visual biofeedback and muscle training as a therapeutic modality in pelvic floor dyssynergia and slow-transit constipation
    Edda Battaglia
    Servizio di Endoscopia e Motilità Intestinale, Cattedra di Medicina Interna, Dipartimento di Fisiopatologia Clinica, Universita di Torino, Torino, Italy
    Dis Colon Rectum 47:90-5. 2004
    ..This study was designed to assess in an objective way the medium- and long-term effects of biofeedback and muscle training in patients with pelvic floor dyssynergia and slow-transit constipation...
  35. pmc Ambulatory high-resolution manometry, lower esophageal sphincter lift and transient lower esophageal sphincter relaxation
    R K Mittal
    Division of Gastroenterology, San Diego VA Health Care System and University of California, San Diego, CA, USA
    Neurogastroenterol Motil 24:40-6, e2. 2012
    Lower esophageal sphincter (LES) lift seen on high-resolution manometry (HRM) is a possible surrogate marker of the longitudinal muscle contraction of the esophagus...
  36. ncbi Ambulatory 24-h colonic manometry in healthy humans
    S S Rao
    Department of Internal Medicine and Clinical Research Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 280:G629-39. 2001
    ..The colon exhibits a wide spectrum of pressure activity around the clock, with gender and regional differences and circadian rhythm. This comprehensive study provides qualitative and quantitative normative data for colonic manometry.
  37. ncbi Gastric tonometry: the hemodynamic monitor of choice (Pro)
    Stephen O Heard
    Department of Anesthesiology, University of Massachusetts Medical School, Worcester 01655, USA
    Chest 123:469S-74S. 2003
    ..For these reasons, gastric tonometry must be considered the hemodynamic monitor of choice...
  38. ncbi Multiple rapid swallowing: a complementary test during standard oesophageal manometry
    F Fornari
    Center for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:718-e41. 2009
    ..inhibitory or excitatory oesophageal mechanisms in patients with oesophageal symptoms and either normal standard manometry or ineffective oesophageal motility (IOM)...
  39. ncbi Criteria for assessing esophageal motility in laparoscopic adjustable gastric band patients: the importance of the lower esophageal contractile segment
    Paul Robert Burton
    Centre for Obesity Research and Education CORE, Monash Medical School, The Alfred Hospital, Commercial RD Prahran, 3181, Melbourne, Australia
    Obes Surg 20:316-25. 2010
    ..Recent combined video fluoroscopic and high-resolution manometric studies have identified important components of esophageal function in LAGB patients...
  40. pmc Manometric features of eosinophilic esophagitis in esophageal pressure topography
    S Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 23:208-14, e111. 2011
    ..The aims of this study were to evaluate the esophageal pressure topography (EPT) findings in EoE and to compare them with controls and patients with gastro-esophageal disease (GERD)...
  41. pmc Weak peristalsis in esophageal pressure topography: classification and association with Dysphagia
    Sabine Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:349-56. 2011
    Esophageal manometry is frequently used to assess for weak peristalsis. Although commonly used clinically, there are currently no validated metrics of weak peristalsis in high-resolution esophageal pressure topography (EPT)...
  42. ncbi Reproducibility of esophageal high-resolution manometry
    A Bogte
    Gastrointestinal Research Unit, Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 23:e271-6. 2011
    Esophageal high-resolution manometry (HRM) is a novel method for esophageal function testing that has prompted the development of new parameters for quantitative analysis of esophageal function...
  43. ncbi Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: assessment by high-resolution manometry
    R Vardar
    Ege University School of Medicine, Division of Gastroenterology, Izmir, Turkey
    Dis Esophagus 26:219-25. 2013
    ..This study applied high-resolution manometry (HRM) to obtain a detailed evaluation of pharyngeal and esophageal motility in chronic cough patients with and ..
  44. ncbi Impedance measurements and high-resolution manometry help to better define rumination episodes
    Boudewijn F Kessing
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center Maastricht, Maastricht, The Netherlands
    Scand J Gastroenterol 46:1310-5. 2011
    ..the diagnosis of rumination syndrome by classification of separate rumination symptoms using (1) an ambulatory manometry/impedance (AMIM) measurement and (2) a single-catheter high-resolution manometry/impedance (HRIM) measurement.
  45. ncbi Measurements of pelvic floor dyssynergia: which test result matters?
    Liliana Bordeianou
    Division of Gastrointestinal Surgery, Pelvic Floor Disorders Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Dis Colon Rectum 54:60-5. 2011
    Failure to expel a 60-mL balloon on manometry and abnormal relaxation of anal sphincter on electromyographic testing are frequently used to diagnose pelvic floor dyssynergia...
  46. ncbi Echocardiography-guided pacemaker optimization and radial artery tonometry
    Tasneem Z Naqvi
    Cardiac Non Invasive Laboratory, Cedars Sinai Medical Center, UCLA David Geffen School of Medicine, Los Angeles, CA 90033, USA
    J Card Fail 14:583-9. 2008
    ..Biventricular (Biv) pacemaker optimization is underused because of time and echo skill required. We evaluated radial artery tonometry during echo-guided Biv optimization of atrioventricular (AV) and interventricular (VV) delays...
  47. ncbi Gastric and sublingual capnometry
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Curr Opin Crit Care 12:272-7. 2006
    ..This review provides an update on these technologies...
  48. ncbi Short course of omeprazole: a better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour esophageal pH monitoring
    William M Pandak
    Division of Gastroenterology and Department of Biostatistics, Virginia Commonweath University, Richmond, Virginia 23249, USA
    J Clin Gastroenterol 35:307-14. 2002
    ..Noncardiac chest pain (NCCP) presents as a frequent diagnostic challenge, with patients tending to use a disproportionate level of health care resources. Gastroesophageal reflux disease (GERD) is the most frequent cause of NCCP...
  49. ncbi A new era in esophageal diagnostics: the image-based paradigm of high-resolution manometry
    Renato Salvador
    Department of Surgery, Division of Thoracic and Foregut Surgery, University of Rochester, Rochester, NY 14642, USA
    J Am Coll Surg 208:1035-44. 2009
    ..HRM may offer advantages over conventional methods, including improved identification of motility disorders, hiatal hernia, and outflow obstruction, and ease interpretation...
  50. ncbi Ejaculatory duct manometry in normal men and in patients with ejaculatory duct obstruction
    Michael L Eisenberg
    Department of Urology, University of California San Francisco, San Francisco, California 94143 1695, USA
    J Urol 180:255-60; discussion 260. 2008
    ..We describe what is to our knowledge a new hydraulic test and report its ability to identify physical and functional ejaculatory duct obstruction...
  51. ncbi Assessment of peripheral vascular endothelial function in the ambulatory setting
    Jeffrey T Kuvin
    Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Vasc Med 12:13-6. 2007
    ..In conclusion, these data suggest that peripheral vascular endothelial function testing is feasible in ambulatory patients, and this is an important next step in bringing this technology to clinical applicability...
  52. pmc High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 135:756-69. 2008
    Both high-resolution manometry (HRM) and impedance-pH/manometry monitoring have established themselves as research tools and both are now emerging in the clinical arena...
  53. ncbi Ambulatory 24-hour colonic manometry in slow-transit constipation
    Satish S C Rao
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Am J Gastroenterol 99:2405-16. 2004
    The colonic neuromuscular dysfunction in patients with constipation and the role of colonic manometry is incompletely understood.
  54. ncbi A novel microbubble construct for intracardiac or intravascular MR manometry: a theoretical study
    Rohan Dharmakumar
    Department of Medical Biophysics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada
    Phys Med Biol 50:4745-62. 2005
    ..5 T must be 2-3 microm in radius and be uniformly coated with single-domain magnetic nanoparticles, such as magnetite, at shell volume fractions below 5%...
  55. pmc High-resolution manometry in clinical practice: utilizing pressure topography to classify oesophageal motility abnormalities
    J E Pandolfino
    Department of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 21:796-806. 2009
    High-resolution manometry capable of pressure monitoring from the pharynx to the stomach together with pressure topography plotting represents an unquestionable evolution in oesophageal manometry...
  56. ncbi Deterioration of muscle function in the human esophagus with age
    Hans Gregersen
    Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital, Aalborg, Denmark
    Dig Dis Sci 53:3065-70. 2008
    ..Esophageal motor function is traditionally studied by means of manometry and radiography...
  57. ncbi NERD, GERD, and Barrett's esophagus: role of acid and non-acid reflux revisited with combined pH-impedance monitoring
    Christian A Gutschow
    Department of Visceral and Vascular Surgery, University of Cologne, Kerpener Strasse 62, 50962, Cologne, Germany
    Dig Dis Sci 53:3076-81. 2008
    ..With introduction of combined esophageal pH-impedance monitoring, a precise diagnostic test for acid and non-acid reflux is now available...
  58. ncbi Oesophageal motility disorders
    J E Richter
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 358:823-8. 2001
    ..Secondary oesophageal motility disorders can be caused by collagen vascular diseases, diabetes, Chagas' disease, amyloidosis, alcoholism, myxo-oedema, multiple sclerosis, idiopathic pseudo-obstruction, or the ageing process...
  59. pmc Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms
    Shahin Ayazi
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Ste 514, Los Angeles, CA 90033, USA
    J Gastrointest Surg 13:1440-7. 2009
    ..The aim of this study is to quantify the relationship between body mass index (BMI) and 24-h esophageal pH measurements and the status of the lower esophageal sphincter (LES) in patients with reflux symptoms...
  60. pmc Classification of oesophageal motility abnormalities
    S J Spechler
    Department of Medicine Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Gut 49:145-51. 2001
    ..This should facilitate and improve comparisons among patients and studies. However, it is important to emphasise that fulfilment of the proposed criteria does not establish the clinical importance of the motility abnormalities...
  61. ncbi Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy
    D Cassilly
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 20:311-9. 2008
    ..Fifteen normal subjects underwent antroduodenal manometry and ingestion of a radiolabelled meal and SmartPill wireless pH and pressure capsule...
  62. ncbi Digital assessment of endothelial function and ischemic heart disease in women
    Yasushi Matsuzawa
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 55:1688-96. 2010
    ....
  63. ncbi Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease
    Kenneth R DeVault
    Department of Medicine, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Am J Gastroenterol 100:190-200. 2005
    ..guidelines address empiric therapy and the use of endoscopy, ambulatory reflux monitoring, and esophageal manometry in GERD...
  64. ncbi Oesophageal high-resolution manometry: moving from research into clinical practice
    M R Fox
    Clinic for Gastroenterology and Hepatology, University Hospital Zurich, CH 4103 Zürich, Switzerland
    Gut 57:405-23. 2008
    b>Manometry measures pressure within the oesophageal lumen and sphincters, and provides an assessment of the neuromuscular activity that dictates function in health and disease...
  65. ncbi Minimum standards of anorectal manometry
    S S C Rao
    University of Iowa, Iowa City 52242, USA
    Neurogastroenterol Motil 14:553-9. 2002
  66. ncbi Assessment of endothelial function using peripheral waveform analysis: a clinical application
    Christopher S Hayward
    Cardiology Department, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Am Coll Cardiol 40:521-8. 2002
    ....
  67. ncbi Functional gallbladder and sphincter of oddi disorders
    Jose Behar
    Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Gastroenterology 130:1498-509. 2006
    ..Biliary-type SO dysfunction is more frequently recognized in postcholecystectomy patients. SO manometry is valuable to select patients with sphincter dysfunction; however, because of the high incidence of ..
  68. ncbi An updated clinical primer on large artery mechanics: implications of pulse waveform analysis and arterial tonometry
    Michael F O'Rourke
    St Vincent s Clinic, University of New South Wales, 438 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Curr Opin Cardiol 20:275-81. 2005
    ..This review summarizes major findings on (a) value of arterial tonometry in determining indices of cardiovascular function, (b) use of these indices in outcome and drug studies, (c) relevance to major trials on blood pressure reduction...
  69. ncbi Effects of anti-reflux surgery on weakly acidic reflux and belching
    J A J L Broeders
    Department of Surgery, University Medical Center Utrecht, Utrecht, The
    Gut 60:435-41. 2011
    ..Weakly acidic reflux and inability to belch have been alleged to cause these symptoms, respectively. The effect of LNF on weakly acidic reflux and (supra) gastric belching was evaluated...
  70. ncbi Total and segmental colonic transit time and anorectal manometry in children with chronic idiopathic constipation
    Carolina Gutierrez
    Service of Pediatrics and Section of Pediatric Surgery, Hospital General Albacete, Albacete and Department of Pediatrics, Hospital Universitario Doce de Octubre, Madrid, Spain
    J Pediatr Gastroenterol Nutr 35:31-8. 2002
    ..Estimating the colonic transit time may help identify subgroups of patients with different physiopathologic mechanisms...
  71. ncbi Effects of age on the gastroesophageal junction, esophageal motility, and reflux disease
    Jacqueline Lee
    Department of Gastroenterology, Guy s and St Thomas Hospital, London, United Kingdom
    Clin Gastroenterol Hepatol 5:1392-8. 2007
    ....
  72. ncbi Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls
    Sudip K Ghosh
    Dept of Medicine, Feinberg School of Medicine, Northwestern Univ, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 293:G878-85. 2007
    Assessing deglutitive esophagogastric junction (EGJ) relaxation is an essential focus of clinical manometry. Our aim was to apply automated algorithmic analyses to high-resolution manometry (HRM) studies to ascertain the optimal method ..
  73. ncbi Characteristics of trapped lung: pleural fluid analysis, manometry, and air-contrast chest CT
    John T Huggins
    Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, PO Box 250625, Charleston, SC 29425, USA
    Chest 131:206-13. 2007
    To review the pleural fluid characteristics, pleural manometry, and radiographic data of patients who received a diagnosis of trapped lung in our pleural diseases service.
  74. pmc Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?
    Stephen H Loring
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:515-22. 2010
    ..We suggest that Pes can be used to estimate transpulmonary pressures that are consistent with known physiology and can provide meaningful information, otherwise unavailable, in critically ill patients...
  75. pmc Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial
    Werner A Draaisma
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Surg 244:34-41. 2006
    ....
  76. ncbi Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers
    Sudip K Ghosh
    Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 N St Clair Street, Suite 1400, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 290:G988-97. 2006
    The vastly enhanced spatial resolution of high-resolution manometry (HRM) makes it possible to simultaneous monitor contractile activity over the entire length of the esophagus...
  77. pmc Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture
    Wilfried Engelke
    Dentistry Centre, Department of Maxillofacial Surgery, University of Gottingen, Gottingen, Germany
    Clin Oral Investig 15:165-76. 2011
    ....
  78. pmc Anatomical registration and three-dimensional visualization of low and high-resolution pan-colonic manometry recordings
    J B Davidson
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Neurogastroenterol Motil 23:387-90, e171. 2011
    ..However, because these motor patterns are typically recorded over long periods (24 h +), the visualization of PS spatiotemporal patterning is difficult. Here, we develop a novel method for displaying pan-colonic motility patterns...
  79. ncbi Tissue capnometry: does the answer lie under the tongue?
    Alexandre Toledo Maciel
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:2157-65. 2004
    ..Although some questions remain to be answered about sublingual capnometry and its utility, this technique could offer new hope for tissue PCO(2) monitoring in clinical practice...
  80. pmc A unique esophageal motor pattern that involves longitudinal muscles is responsible for emptying in achalasia esophagus
    Su Jin Hong
    Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, South Korea
    Gastroenterology 139:102-11. 2010
    ..We studied mechanisms of esophageal emptying in patients with achalasia using simultaneous high-resolution manometry, multiple intraluminal impedance, and high-frequency intraluminal ultrasonography image recordings.
  81. ncbi Anorectal manometry in patients with chronic constipation: a single-center experience
    Tso Tsai Liu
    Division of Gastroenterology and Hepatology, Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien, Taiwan
    Hepatogastroenterology 55:426-9. 2008
    ..Constipation is a common complaint, but its clinical presentation varies with each individual. The aim of this study was to evaluate anorectal physiology in a prospective group of patients with chronic constipation...
  82. ncbi Black race is associated with digital artery endothelial dysfunction: results from the Heart SCORE study
    Suresh R Mulukutla
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Eur Heart J 31:2808-15. 2010
    ..Accordingly, we evaluated race-related differences in digital pulse amplitude tonometry (PAT) response to an endothelium-dependent vasodilatory stimulus...
  83. ncbi Treatment of achalasia: botulinum toxin injection vs. pneumatic balloon dilation. A prospective study with long-term follow-Up
    H D Allescher
    Department of Internal Medicine II, Technical University of Munich, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Endoscopy 33:1007-17. 2001
    ..The aim of the present study was to test the effectiveness, the long-term outcome and the cumulative costs of BTX injection in consecutive patients with symptomatic achalasia in comparison with pneumatic balloon dilation...
  84. ncbi Esophageal manometry: assessment of interpreter consistency
    Devjit S Nayar
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 3:218-24. 2005
    b>Manometry is used widely in the evaluation of esophageal disorders. Our aim was to assess the intra- and interobserver reliability of esophageal manometry and identify potential causes for diagnostic variability.
  85. pmc Accurate positioning of the 24-hour pH monitoring catheter: agreement between manometry and pH step-up method in two patient positions
    Mehmet Fatih Can
    Department of General Surgery, Gulhane Military Medical Academy, Kent Koop Mh 11 Cd Guneyce Merkez Sit A 10, 06370, Batikent Ankara, Turkey
    World J Gastroenterol 13:6197-202. 2007
    To investigate the agreement between esophageal manometry and pH step-up method in two different patient positions.
  86. ncbi Preoperative MRI sphincter morphology and anal manometry: can they be markers of functional outcome following anterior resection for rectal cancer?
    P How
    Pelican Cancer Foundation, Dinwoodie Drive, Basingstoke, UK
    Colorectal Dis 14:e339-45. 2012
    ..Assessments such as anal manometry have been advocated as a potential tool but functional anatomy as depicted on MRI has not been investigated...
  87. ncbi Electrical stimulation and pelvic floor muscle training with biofeedback in patients with fecal incontinence: a cohort study of 281 patients
    M P Terra
    Department of Radiology, Academic Medical Center, G1 229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Dis Colon Rectum 49:1149-59. 2006
    ..This study was designed to assess the outcome of pelvic floor rehabilitation in a large series of consecutive patients with fecal incontinence caused by different etiologies...
  88. ncbi Gastroesophageal flap valve is associated with gastroesophageal and gastropharyngeal reflux
    Gwang Ha Kim
    Department of Internal Medicine, Pusan National University College of Medicine, 1 10 Ami dong, Seo Gu, Busan, 602 739, Korea
    J Gastroenterol 41:654-61. 2006
    ..The endoscopic grade of the gastroesophageal flap valve (GEFV) is suggested to be a good predictor of reflux status. The aim of this study was to investigate the association of the GEFV and gastroesophageal and gastropharyngeal reflux...
  89. ncbi Multichannel intraluminal impedance for the assessment of post-fundoplication dysphagia
    T Yigit
    The Swallowing Center, Department of Surgery, University of Washington, Seattle, WA, USA
    Dis Esophagus 19:382-8. 2006
    ..esophageal clearance with multichannel intraluminal impedance (MII) along with more traditional work-up (manometry, upper gastrointestinal imaging [UGI], endoscopy)...
  90. ncbi A dysphagia study in patients with sporadic inclusion body myositis (s-IBM)
    Ken Ya Murata
    Department of Neurology, Wakayama Medical University, 840 1 Kimii dera, Wakayama 641 8510, Japan
    Neurol Sci 33:765-70. 2012
    ..study, we examined ten consecutive s-IBM patients using videofluoroscopy (VF) and computed pharyngoesophageal manometry (CPM). The patients were divided into two groups: patients with complaint and without complaint of dysphagia...
  91. pmc Non-invasive measurement of local pulse pressure by pulse wave-based ultrasound manometry (PWUM)
    J Vappou
    Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA
    Physiol Meas 32:1653-62. 2011
    ..The objective of this study is to introduce pulse wave-based ultrasound manometry (PWUM) as a simple-to-use, non-invasive ultrasound-based method for quantitative measurement of the central ..
  92. ncbi Esophagography predicts favorable outcomes after laparoscopic Nissen fundoplication for patients with esophageal dysmotility
    Matthew J D'Alessio
    Department of Surgery, University of South Florida College of Medicine, Tampa, FL, USA
    J Am Coll Surg 201:335-42. 2005
    ..We undertook this study to determine if clearance of a food bolus at preoperative esophagography predicts acceptable outcomes after laparoscopic Nissen fundoplication for patients with manometrically abnormal esophageal motility...
  93. ncbi The functional lumen imaging probe (FLIP) for evaluation of the esophagogastric junction
    Barry P McMahon
    Centre for Visceral Biomechanics and Pain, Aalborg Hospital, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Am J Physiol Gastrointest Liver Physiol 292:G377-84. 2007
    ..The EGJ was located by manometry. The FLIP measured eight cross-sectional areas (CSAs) 4 mm apart together with the pressure inside a saline-..
  94. ncbi Is dynamic two-dimensional anal ultrasonography useful in the assessment of anismus? A comparison with manometry
    Sthela Maria Murad-Regadas
    Departamento de Cirurgia, Universidade Federal do Ceara, Fortaleza, CE, Brazil
    Arq Gastroenterol 47:368-72. 2010
    ..Anismus is a prevalent functional cause of outlet delay. It is characterized by symptoms of obstructed defecation associated with paradoxical contraction of the pelvic floor muscles...
  95. ncbi Digital rectal examination is a useful tool for identifying patients with dyssynergia
    Kasaya Tantiphlachiva
    Division of Gastroenterology and Hepatology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Clin Gastroenterol Hepatol 8:955-60. 2010
    ..It is not known whether digital rectal examination (DRE) can be used to identify dyssynergia. We examined the diagnostic yield of DRE in patients with dyssynergic defecation...
  96. ncbi Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth
    Mark Pimentel
    GI Motility Program, Department of Medicine, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Dig Dis Sci 47:2639-43. 2002
    ..After fluoroscopic placement of an eight-channel water-perfused manometry catheter, 4-hr fasting recordings were obtained...
  97. ncbi Minimally invasive measurement of esophageal variceal pressure and wall tension (with video)
    Anil K Vegesna
    Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Gastrointest Endosc 70:407-13. 2009
    ..There is no simple method to measure intravariceal pressure in patients with esophageal varices...
  98. ncbi Computerized endoscopic balloon manometry to detect esophageal variceal pressure
    D R Kong
    Department and Key Laboratory of Gastroenterology, Anhui Geriatric Institute, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, PR China
    Endoscopy 41:415-20. 2009
    ..We have developed a computerized endoscopic balloon manometry (CEBM) system to detect variceal pressure...
  99. pmc Esophageal dysmotility in children with eosinophilic esophagitis: a study using prolonged esophageal manometry
    Samuel Nurko
    Center for Motility and Functional Gastrointestinal Disorders, and Eosinophilic Gastrointestinal Diseases Program, Children s Hospital Boston, Boston, Massachusetts 02155, USA
    Am J Gastroenterol 104:3050-7. 2009
    ..Symptoms rarely occur during stationary esophageal manometry, so it has been difficult to establish an association between symptoms and motor events...
  100. ncbi Anorectal function testing and anal endosonography in the diagnostic work-up of patients with primary pelvic organ prolapse
    Annette G Groenendijk
    Department of Gynecology and Obstetrics, Onze Lieve Vrouwe Hospital, Amsterdam, The Netherlands
    Gynecol Obstet Invest 67:187-94. 2009
    ..To study the pathophysiology of defecation disorders in patients with primary pelvic organ prolapse (POP) and the diagnostic potential of anorectal function testing (AFT) including endosonography in the work-up of these patients...
  101. pmc Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors
    G Gourcerol
    CURE Digestive Diseases Research Center and Center for Stress Neurobiology, UCLA, VA Greater Los Angeles Healthcare System, CURE Bldg 115, Rm 118B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 296:G992-G1002. 2009
    ..Noninvasive colonic manometry opens new venues to investigate colonic motor function in genetically modified mice relevant to diseases that ..

Research Grants64

  1. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..Current diagnostic tests for OD (anorectal manometry, defecography, rectal balloon expulsion) are neither standardized nor reproducible; endoanal ultrasound is ..
  2. Planning Grant for SOD III Multicenter Trial
    Peter Cotton; Fiscal Year: 2004
    ..Sphincter of Oddi manometry (SOM) is used for diagnosis, but is not widely available, not completely accurate, and can cause pancreatitis...
  3. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..In this proposal, in addition to identifying demographic features, we will also perform esophageal manometry, esophageal and hypopharyngeal pH monitoring and multichannel intraluminal impedance (MII) pre- and post-therapy ..
  4. High-Definition Manometry: A Novel Diagnostic Tool
    Thomas Parks; Fiscal Year: 2006
    ..g., suffering, functional impairment, and health care resource use). Intraluminal manometry is an important diagnostic tool, but technological limitations of current devices having relatively few pressure ..
  5. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..Lung volumes can be monitored with magnetometers, and esophageal manometry will be used to estimate transpulmonary pressures...
  6. Gastroesophageal Antireflux Mechanisms
    MICHAEL RAYMOND RUGGIERI; Fiscal Year: 2013
    ..The first approach uses simultaneous high-resolution ultrasonography and vector volume manometry before and after pharmacologic manipulation to inhibit the smooth muscle component (atropine) augment the smooth ..
  7. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
    ..contraction of the longitudinal muscles of the esophagus and thus could not be recorded by intraluminal manometry. During last funding period, we have made number of observations with regards to the role of longitudinal ..
  8. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2013
    ..This will be done in conjunction with the intraluminal manometry and the IAS SM function...
  9. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2013
    ..This proposal will evaluate the use of two novel technologies (3D- high resolution manometry (3D-HRM) and EndoFLIP(R)) to objectify GERD diagnostics...
  10. The Role of Lung Volumes in Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2010
    ..Lung volumes can be monitored with magnetometers, and esophageal manometry will be used to measure transpulmonary pressures...
  11. The Role of Microaspiration in Idiopathic Pulmonary Fibrosis
    JOYCE SUJIN LEE; Fiscal Year: 2011
    ..for microaspiration in IPF (Aim 2) will be identified using esophageal function studies (24h pH monitoring and manometry), laboratory tests, radiological imaging, and survey...
  12. Evaluating Predictors &Interventions in Sphincter of Oddi Dysfunction (EPISOD)
    Peter B Cotton; Fiscal Year: 2013
    ..A 2:1 randomization allocation in favor of sphincterotomy and stratified by results of sphincter manometry (SOM - abnormal/normal) and center will be used...
  13. SoundTrak: A Data Acquisition and Analysis System for OSDB
    B Parker; Fiscal Year: 2009
    ..In particular, traditional overnight laboratory polysomnography, augmented to include esophageal manometry and/or pulse transit time measurement, will be compared with multi-night in-home sleep studies based on an easy-..
  14. High Resolution Manometry: A Novel Pattern Recognition Method for Dysphagia
    Timothy M McCulloch; Fiscal Year: 2012
    ..High Resolution Manometry (HRM) can directly measure these pressure patterns along the length of the pharynx and provides a quantifiable, ..
  15. High Resolution Manometry: A Novel Pattern Recognition Method for Dysphagia
    Timothy M McCulloch; Fiscal Year: 2013
    ..High Resolution Manometry (HRM) can directly measure these pressure patterns along the length of the pharynx and provides a quantifiable, ..
  16. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    ..in the gastric corpus, antrum and duodenum will be measured using a multilumen catheter for perfused side hole manometry in combination with a sleeve sensor to simultaneously measure pyloric pressure...
  17. Is small intestinal bacterial overgrowth associated with functional dyspepsia?
    Henry C Lin; Fiscal Year: 2010
    ..We will compare symptom scores recorded on questionnaires, LBT results, small bowel manometry, and volume of tolerance of a nutritive drink before and after treatment of SIBO...
  18. Development and Validation of test for Gastro-esophageal Reflux with Aspiration
    Igor Gonda; Fiscal Year: 2013
    ..The tests currently available, esophageal manometry and 24h pH monitoring, or scintigraphy, are expensive, technically difficult and indirect, or involve ..
  19. SPHINCTER OF ODDI FUNCTION IN HEALTH AND DISEASE
    Walter Hogan; Fiscal Year: 1990
    ..Recent advances in instrumentation now allow high-fidelity intraluminal manometry of the biliary-pancreatic duct systems in both humans and experimental animals...
  20. An Intelligent 32-Site Esophageal Manometry System
    COLLIN RICH; Fiscal Year: 2001
    ..abstract_text> ..
  21. ORAL MECHANISMS IN SWALLOWING
    THOMAS GAY; Fiscal Year: 1993
    ..research on swallowing has focused on the pharyngeal and esophageal components using cineradiography and manometry. However, the importance of the oral component of swallowing is becoming increasingly apparent, both from the ..
  22. PREDICTING THE INSERTION LENGTH FOR GASTRIC GAVAGE TUBES
    Jan Beckstrand; Fiscal Year: 1992
    ..recommended in the literature and the actual distance to the stomach measured in endoscopy and esophageal manometry subjects...
  23. Ultra-Sonic Non-Contact Tonometer in Glaucoma-IOP Checks
    Peter Gross; Fiscal Year: 2005
    ..will progress to USNCT measurements of freshly enucleated cadaver eyes with IOP controlled by intracameral manometry. Absolute calibration with known IOP will thus be possible; relative comparisons to some other tonometers will ..
  24. CLINICAL-RESEARCH SWALLOWING MOTILITY DIAGNOSTIC SYSTEM
    James Brasseur; Fiscal Year: 1999
    ..practice, (c) potentially reduces the use of radiation through more sophisticated application of intraluminal manometry, and (d) is designed for continual advancement in the state- of-the-art...
  25. DEVELOPMENT OF MOTILITY VISUALIZATION SYSTEM
    JAE SON; Fiscal Year: 2002
    ..In diagnosing many such disorders, manometry remains the gold standard because of its sensitivity to motor dysfunction...
  26. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  27. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  28. A MINIMALLY INVASIVE MOTILITY VISUALIZING SYSTEM
    JAE SON; Fiscal Year: 1999
    ..This has the immediate clinical benefit of improving esophageal manometry and allows application of these techniques to other parts of the gastrointestinal tract...
  29. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis. ..
  30. ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCE
    RAVINDER MITTAL; Fiscal Year: 2007
    ..Our preliminary studies using 3D ultrasound and manometry show that during voluntary contraction, the PRM increases pressure in the proximal (cranial) part of the anal ..
  31. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  32. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  33. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  34. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  35. Comparison of Two Therapies for UES Dysphagia
    Reza Shaker; Fiscal Year: 2004
    ..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
  36. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  37. FLAVANOL-RICH COCOA TO REVERSE VASCULAR DISEASE OF AGING
    Naomi Fisher; Fiscal Year: 2006
    ..She will be well-positioned to submit an application for an RO1 with results from this study. Therapeutic interventions aimed at restoring vascular endothelial function hold tremendous clinical promise. ..
  38. MUSCLE OVEREXERTION DURING REPETITIVE LIFTING
    William Marras; Fiscal Year: 2003
    ..These results will provide quantitative guidance for the mediation of work-related LBDs for the millions of workers performing materials handling tasks in manufacturing and distribution center environments. ..
  39. BIOMECHANICAL/PSYCHOSOCIAL RISKS FOR LOW BACK DISORDERS
    William Marras; Fiscal Year: 2003
    ..We will also be able to discern when and under what conditions an intervention to improve the psycho social work environment will be likely to reduce LBP and its associated morbidity. ..
  40. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  41. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  42. PLACEBO CONTROLLED STUDY OF BACLOFEN FOR GERD IN CHILDREN WITH CEREBRAL PALSY
    Samuel Nurko; Fiscal Year: 2008
    ..This study will serve as a basis to test the medication in otherwise healthy children with GERD. [unreadable] [unreadable] [unreadable]..
  43. Modeling and Assessment of Cerebrovascular Autoregulation
    Michael Daley; Fiscal Year: 2006
    ..Simulation of ICP with a third order windkessel model of intracranial pressure dynamics will be used to examine the biomechanical mechanisms underlying active and passive regulation of cerebral blood flow. [unreadable] [unreadable]..
  44. Neuro-Fuzzy Prediction of Spine Loads in Response to Ri*
    William Marras; Fiscal Year: 2005
    ..Second, the system will provide insights as to how the various dimensions of risk synergistically impact the musculoskeletal system. Finally, it will facilitate further investigations regarding stability and coactivity. ..
  45. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  46. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  47. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2006
    ..Simultaneous high-resolution ultrasound and manometry will be utilized to correlate anatomical position (structure) with pressure (function)...
  48. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  49. Home-based vs. Supervised Exercise for Claudicants
    Andrew W Gardner; Fiscal Year: 2010
    ....
  50. RNAi Mediated Gene Disruption in Caenorhabditis Elegans
    Wayne Van Voorhies; Fiscal Year: 2006
    ..Such worms could identify candidate genes affecting processes that act "downstream" from the metabolic rate and provide valuable insights into the causes of aging and mechanisms by which it can be attenuated. ..
  51. International Conference on Advances in Laryngeal Biophysiology
    Susan Thibeault; Fiscal Year: 2008
    ..The multifactorial nature of voice disorders necessitates study for a comprehensive understanding of the disease mechanisms for optimal treatment success. [unreadable] [unreadable] [unreadable] [unreadable]..
  52. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  53. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  54. BIOSENSOR DETECTION OF WATER-BORNE CRYPTOSPORIDIUM
    Theodore Sand; Fiscal Year: 2002
    ..proposed commercial application: not available..
  55. Music Therapy for Cancer Patients at the End of Life
    Kristine Nelson; Fiscal Year: 2004
    ....
  56. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  57. Microvascular Function in Chronic Kidney Disease
    David Edwards; Fiscal Year: 2008
    ..Understanding these mechanisms may aid in the evaluation of therapies aimed at improving vascular function in chronic kidney disease. ..
  58. Tongue Strength Exercise and Swallowing in Oral Cancer
    Cathy Lazarus; Fiscal Year: 2007
    ..Dependant variables include maximum tongue strength, temporal swallow measures of oral and pharyngeal transit times, bolus volume and viscosity, the Oropharyngeal Swallow Efficiency (OPSE) measure, and quality of life ratings. ..
  59. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
    ..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
  60. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    James Brandt; Fiscal Year: 2008
    ....
  61. In-Shoe Shear Stress Sensor For Diabetic Patient
    Wei Chih Wang; Fiscal Year: 2005
    ..A wearable (in-shoe) or embedded (active shoe, or prosthesis) sensor can be derived from this sensor. Other sensors can also be incorporated into the polymer-based sheet to create a multi-parameter sensor system. ..