serotyping

Summary

Top Publications

  1. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
  2. doi Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
  3. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
  4. doi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
  5. pmc Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes
    Stephen D Bentley
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 2:e31. 2006
  6. pmc Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray
    Paul Turner
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    J Clin Microbiol 49:1784-9. 2011
  7. ncbi Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group
    S Black
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 19:187-95. 2000
  8. pmc Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands
    Judith Spijkerman
    University Medical Center, Utrecht, The Netherlands
    Emerg Infect Dis 17:584-91. 2011
  9. doi Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London, UK
    Lancet Infect Dis 11:760-8. 2011
  10. pmc Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study
    Stefan Flasche
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS Med 8:e1001017. 2011

Research Grants

  1. OUTER MEMBRANE PROTEINS OF NONTYPEABLE H. INFLUENZAE
    Timothy Murphy; Fiscal Year: 1993
  2. GENETIC BASIS OF PEANUT ALLERGY
    Scott Sicherer; Fiscal Year: 2004
  3. CLONAL DIVERSITY OF ORAL PATHOGENS
    C Chen; Fiscal Year: 2003
  4. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2007
  5. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2007
  6. Role of Enterococcal Polysaccharides in Virulence
    Johannes Huebner; Fiscal Year: 2006
  7. Microarray-based detection and typing of rhinoviruses
    Homer Boushey; Fiscal Year: 2005
  8. Genetic Resistance to Oncogenic Human Papillomaviruses
    Stephen Tyring; Fiscal Year: 2004
  9. Post-PCV pneumococcal population genetics and resistance
    Jonathan Finkelstein; Fiscal Year: 2007
  10. Post-PCV pneumococcal population genetics and resistance
    Jonathan Finkelstein; Fiscal Year: 2009

Detail Information

Publications269 found, 100 shown here

  1. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
    ..6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type...
  2. doi Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
    ....
  3. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
    ....
  4. doi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
    ..Changes in invasive pneumococcal disease (IPD) incidence were evaluated after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children...
  5. pmc Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes
    Stephen D Bentley
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 2:e31. 2006
    ..of the genetics and origins of bacterial polysaccharide diversity, laying the foundations for molecular serotyping. This is the first time, to our knowledge, that a complete repertoire of capsular biosynthetic genes has been ..
  6. pmc Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray
    Paul Turner
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    J Clin Microbiol 49:1784-9. 2011
    ..Conventional nasopharyngeal swab (NPS) culture and serotyping (the WHO protocol) is likely to underestimate multiple-serotype carriage...
  7. ncbi Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group
    S Black
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 19:187-95. 2000
    ....
  8. pmc Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands
    Judith Spijkerman
    University Medical Center, Utrecht, The Netherlands
    Emerg Infect Dis 17:584-91. 2011
    ..PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination...
  9. doi Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London, UK
    Lancet Infect Dis 11:760-8. 2011
    ..We assess the effect of the PCV7 vaccination on VT and NVT disease in England and Wales...
  10. pmc Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study
    Stefan Flasche
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS Med 8:e1001017. 2011
    ....
  11. ncbi Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
    ..pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques...
  12. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
    ..This study assessed the efficacy of a novel vaccine that contained polysaccharides from 11 different Streptococcus pneumoniae serotypes each conjugated to Haemophilus influenzae-derived protein D in prevention of acute otitis media...
  13. doi Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity
    Martin C J Maiden
    Dept of Zoology, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom
    J Infect Dis 197:737-43. 2008
    ..The impact of this intervention on asymptomatic carriage of meningococci was investigated to establish whether serogroup replacement or protection by herd immunity occurred...
  14. pmc Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates
    Rekha Pai
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 44:124-31. 2006
    Accurate serotyping is essential to monitor the changes in the seroepidemiology of Streptococcus pneumoniae...
  15. pmc A new pneumococcal serotype, 11E, has a variably inactivated wcjE gene
    Juan J Calix
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Infect Dis 202:29-38. 2010
    ..We propose to name the 11Aalpha subtype as serotype 11A and the 11Abeta subtype as 11E, a new serotype. Our findings also suggest that the diversity of pneumococcal capsules is much greater than was previously recognized...
  16. ncbi Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
    Lauri A Hicks
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1346-54. 2007
    ..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
  17. ncbi Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003
    Richard A Adegbola
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Trop Med Int Health 11:1128-35. 2006
    ..To describe the characteristics of pneumococcal isolates obtained from patients with invasive pneumococcal disease in The Gambia...
  18. pmc Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
    J C Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    Clin Microbiol Rev 11:450-79. 1998
    ..This, in turn, has created a potential window of opportunity for future therapeutic intervention...
  19. doi Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    Clin Infect Dis 50:1468-76. 2010
    ..pneumoniae in rural Africa and a baseline for evaluating the impact of the introduction of pneumococcal conjugate vaccine into the region...
  20. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Clin Infect Dis 43:673-9. 2006
    ..To prepare for the introduction of a pneumococcal conjugate vaccine of restricted valency, we studied the nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers...
  21. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
    ....
  22. pmc Simple, rapid latex agglutination test for serotyping of pneumococci (Pneumotest-Latex)
    H C Slotved
    Serum Production Unit, Department of Bacteriology, Mycology and Parasitology, Division of Microbiology and Diagnostics, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Clin Microbiol 42:2518-22. 2004
    ..e., serotyping. The method is labor intensive and requires a certain level of experience to be performed satisfactory, and thus ..
  23. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..However, the relationship between the clinical presentation and bacterial factors remains unclear. The aim of this study was to investigate the clinical features of patients and the serotype and ribotype of K pneumoniae liver abscess...
  24. ncbi Genetic analysis of meningococci carried by children and young adults
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Infect Dis 191:1263-71. 2005
    ..The relationship between meningococcal genotype and capsular polysaccharide, the principal virulence factor and vaccine component, was investigated in carried meningococci isolated from 8000 children and young adults in Bavaria, Germany...
  25. pmc Continued impact of pneumococcal conjugate vaccine on carriage in young children
    Susan S Huang
    Division of Infectious Diseases, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Pediatrics 124:e1-11. 2009
    ....
  26. pmc A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting
    M Hussain
    Immunisation Department, Communicable Disease Surveillance Centre, Health Protection Agency Centre for Infections, London, UK
    Epidemiol Infect 133:891-8. 2005
    ..pneumoniae is common in a UK setting in the pre-conjugate vaccine era. PCV would protect against a large proportion of carriage isolates. However, the impact of vaccination on non-vaccine serotypes will need to be monitored...
  27. ncbi Serotype-specific differences in clinical manifestations of dengue
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Managua, Nicaragua
    Am J Trop Med Hyg 74:449-56. 2006
    ..86, CI 2.72-5.48) and more primary DENV infections with severe manifestations (OR 2.93, CI 2.00-4.28). These findings provide new data to characterize the pathogenic potential of distinct DENV serotypes in human populations...
  28. doi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia
    Clin Infect Dis 46:807-14. 2008
    ..To prepare for national introduction of a pneumococcal conjugate vaccine of restricted valency, we studied nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants...
  29. ncbi An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 192:192-9. 2005
    ..These epidemics are generally caused by Neisseria meningitidis, an organism that is considered to be uniquely capable of causing meningitis epidemics...
  30. pmc Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae
    In Ho Park
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 614, Birmingham, AL 35294, USA
    J Clin Microbiol 45:1225-33. 2007
    ..This study also demonstrates that a new serotype may exist within an established and well-characterized serogroup or serotype...
  31. ncbi Non-O157 Shiga toxin-producing Escherichia coli infections in the United States, 1983-2002
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:1422-9. 2005
    ..Non-O157 STEC contribute to this burden of illness but have been underrecognized as a result of diagnostic limitations and inadequate surveillance...
  32. ncbi Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 45:284-93. 2007
    ..There are limited data regarding the role of bacterial genotype in the pathogenesis of this syndrome...
  33. ncbi The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli; under-rated pathogens
    Karl A Bettelheim
    Crit Rev Microbiol 33:67-87. 2007
    ..The animal host-specificity of these STEC is also reviewed. In conclusion some methods of improving isolation of these pathogens is addressed...
  34. doi Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  35. pmc Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Infect Dis 51:692-9. 2010
    ..We evaluated whether risk of death due to IPD is a stable serotype-associated property across studies and then compared the pooled effect estimates with epidemiologic and biological correlates...
  36. ncbi Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential
    Angela B Brueggemann
    Academic Department of Microbiology and Infectious Disease, John Radcliffe Hospital and Department of Public Health and Primary Care, University of Oxford, Oxford, United Kingdom
    J Infect Dis 187:1424-32. 2003
    ....
  37. pmc Characterization of culture-positive adenovirus serotypes from respiratory specimens in Toronto, Ontario, Canada: September 2007-June 2008
    Rani Yeung
    Ministry of Health and Long Term Care, Public Health Laboratories Branch, Etobicoke, Ontario, Canada
    Virol J 6:11. 2009
    ..Molecular methods allow for the determination of circulating adenovirus serotypes and be used to document the spread of highly virulent adenoviral serotypes into a region...
  38. ncbi Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 368:1495-502. 2006
    ..Our aim was to assess the effectiveness of the vaccine against various pneumococcal serotypes, and to measure the effectiveness of the recommended dose schedule and of catch-up and incomplete schedules...
  39. pmc Establishment of a universal size standard strain for use with the PulseNet standardized pulsed-field gel electrophoresis protocols: converting the national databases to the new size standard
    Susan B Hunter
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop C03, Atlanta, GA 30333, USA
    J Clin Microbiol 43:1045-50. 2005
    ..The strategy used to convert and compare data generated by the new and old reference standards is described...
  40. pmc Multilocus sequence typing as a replacement for serotyping in Salmonella enterica
    Mark Achtman
    Environmental Research Institute and Department of Microbiology, University College Cork, Cork, Ireland
    PLoS Pathog 8:e1002776. 2012
    ..An inability of serotyping to correctly group isolates was most apparent for Paratyphi B and its variant Java...
  41. pmc Carried pneumococci in Massachusetts children: the contribution of clonal expansion and serotype switching
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Pediatr Infect Dis J 30:302-8. 2011
    ..Vaccination against 7 serotypes of Streptococcus pneumoniae has led to the near extinction of vaccine serotypes in both disease and asymptomatic carriage. In carriage, vaccine serotypes have been replaced by nonvaccine serotypes...
  42. pmc Serotype-specific detection of dengue viruses in a fourplex real-time reverse transcriptase PCR assay
    Barbara W Johnson
    Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort, Collins, CO 80521
    J Clin Microbiol 43:4977-83. 2005
    ..reverse transcriptase PCR nucleic acid detection assay can be used as a method for differential diagnosis of a specific DEN serotype in viremic dengue patients and as a tool for rapid identification and serotyping of DEN virus isolates.
  43. pmc 7-Valent pneumococcal conjugate vaccination in England and Wales: is it still beneficial despite high levels of serotype replacement?
    Yoon Hong Choi
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS ONE 6:e26190. 2011
    ..However, recent surveillance data show a more rapid replacement of PCV7 IPD cases by non-PCV7 IPD cases than was seen in the US...
  44. ncbi Meningococcal meningitis: unprecedented incidence of serogroup X-related cases in 2006 in Niger
    Pascal Boisier
    centre de recherche médicale et sanitaire, Réseau International des Instituts Pasteur, Niamey, Niger
    Clin Infect Dis 44:657-63. 2007
    ..However, since 2002, Nm serogroup W135 has been considered to be a major threat that has not yet been realized, and an unprecedented incidence of Nm serogroup X (NmX) meningitis was observed in 2006...
  45. ncbi Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nature 413:848-52. 2001
    ..typhi. CT18 harbours a 218,150-bp multiple-drug-resistance incH1 plasmid (pHCM1), and a 106,516-bp cryptic plasmid (pHCM2), which shows recent common ancestry with a virulence plasmid of Yersinia pestis...
  46. doi Effectiveness of the new serotypes in the 13-valent pneumococcal conjugate vaccine
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Services, Colindale, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    Vaccine 29:9127-31. 2011
    ..VE for serotypes 1 and 3 was 62% and 66% respectively although confidence intervals spanned zero. IPD due to PCV13-only serotypes halved in children under 2 years in the study period...
  47. doi Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination
    H J Adam
    Department of Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Vaccine 28:4073-8. 2010
    ..Health Laboratories-Toronto, Ontario Agency for Health Protection and Promotion, which performed almost all serotyping on invasive (blood, CSF, other sterile sites) H...
  48. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    ....
  49. pmc Streptococcus pneumoniae serotype 19A in children, South Korea
    Eun Hwa Choi
    Seoul National University College of Medicine, Seoul, South Korea
    Emerg Infect Dis 14:275-81. 2008
    ..005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use...
  50. ncbi Epidemiological and molecular characteristics of a highly lethal pneumococcal meningitis epidemic in Burkina Faso
    Seydou Yaro
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    Clin Infect Dis 43:693-700. 2006
    ..Public health and clinical strategies for meningitis epidemics in sub-Saharan Africa usually assume that Neisseria meningitidis infection causes most disease...
  51. ncbi Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo
    Christina A Pacak
    Center for Fetal Monkey Gene Transfer for Heart, Lung and Blood Diseases, California National Primate Research Center, Davis, USA
    Circ Res 99:e3-9. 2006
    ....
  52. doi Invasive disease and paediatric carriage of Streptococcus pneumoniae in Ghana
    Eric S Donkor
    Department of Microbiology, University of Ghana Medical School, Accra, Ghana
    Scand J Infect Dis 42:254-9. 2010
    ..Invasive and nasopharyngeal specimens were screened for S. pneumoniae, and isolates were subjected to serotyping, multilocus sequence typing (MLST) and antibiotic susceptibility testing. Overall, the prevalence of S...
  53. pmc Capsular polysaccharide synthesis regions in Klebsiella pneumoniae serotype K57 and a new capsular serotype
    Yi Jiun Pan
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Clin Microbiol 46:2231-40. 2008
    ..PCR using primers from specific genes for K57 was more sensitive and specific than traditional serotyping. The remaining strain, A1517, did not react to the antisera from any of the 77 serotypes, and none of the 77 ..
  54. pmc Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease
    Alessia Melegaro
    DONDENA Centre for Research on Social Dynamics, Bocconi University, Via Guglielmo Rontgen, Milan, Italy
    BMC Infect Dis 10:90. 2010
    ..However the long term effects of PCV are still unclear, as beneficial direct and herd immunity effects might be countered by serotype replacement...
  55. pmc Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine
    Silvio D Brugger
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    PLoS ONE 5:e11638. 2010
    ..We studied the epidemiology of cocolonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal vaccine (PCV7)...
  56. doi New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  57. pmc Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study
    Zitta B Harboe
    Department of Bacteriology, Statens Serum Institut, Copenhagen
    PLoS Med 6:e1000081. 2009
    ..Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD)...
  58. pmc Identification of natural pneumococcal isolates expressing serotype 6D by genetic, biochemical and serological characterization
    Preston E Bratcher
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Microbiology 156:555-60. 2010
    ..However, we now report the discovery of two naturally occurring pneumococcal isolates from Korea that have the serological, genetic and biochemical features predicted for serotype 6D...
  59. doi First report of putative Streptococcus pneumoniae serotype 6D among nasopharyngeal isolates from Fijian children
    Ping Jin
    Bao an Maternity and Child Health Hospital, Shenzhen, People s Republic of China
    J Infect Dis 200:1375-80. 2009
    ..A putative Streptococcus pneumoniae serotype, 6D, resulting from the introduction of wciN(beta) into serotype 6B has been proposed...
  60. pmc Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministry of Health, Nicaragua
    J Infect Dis 201:5-14. 2010
    ..Dengue is the most prevalent mosquito-borne viral disease in humans and a major urban public health problem worldwide...
  61. ncbi Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
    Timothy P Endy
    Division of Virology, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Materiel Command, Ft Detrick, Maryland, USA
    J Infect Dis 189:990-1000. 2004
    ..Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood...
  62. doi Supplement 2003-2007 (No. 47) to the White-Kauffmann-Le Minor scheme
    Martine Guibourdenche
    Institut Pasteur, WHO Collaborating Center for Reference and Research on Salmonella, Unité de Biodiversité des Bactéries Pathogènes Emergentes, Paris, France
    Res Microbiol 161:26-9. 2010
    ..One new serovar, Mygdal, displayed a new H factor, H:z(91)...
  63. pmc The descriptive epidemiology of Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal carriage in children and adults in Kilifi district, Kenya
    Osman Abdullahi
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatr Infect Dis J 27:59-64. 2008
    ..In East Africa we do not know how these pathogens are transmitted between population subgroups nor which serotypes circulate commonly...
  64. doi Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines
    Daniel J Isaacman
    Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA, USA
    Int J Infect Dis 14:e197-209. 2010
    ..The overall reported burden of invasive pneumococcal disease (IPD) varies among countries in Europe. This review describes the epidemiology and serotype distribution of IPD in European children from studies published from 1990 to 2008...
  65. doi Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial
    Elske J M van Gils
    Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children s Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    JAMA 302:159-67. 2009
    ..The effects of reduced-dose schedules of 7-valent pneumococcal conjugate vaccine (PCV-7) on pneumococcal carriage in children are largely unknown, although highly relevant in the context of subsequent herd effects...
  66. ncbi Capsular serotype-specific attack rates and duration of carriage of Streptococcus pneumoniae in a population of children
    Karen L Sleeman
    University Department of Paediatrics, Oxford Vaccine Group, John Radcliffe Hospital, University of Oxford, Headington, Oxford, OX3 9DU, United Kingdom
    J Infect Dis 194:682-8. 2006
    ....
  67. doi Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccine
    R Sá-Leão
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Clin Microbiol Infect 15:1002-7. 2009
    ..Rates of antibiotic resistance remained unchanged due to a balance between reduction in VT and an increase in antimicrobial-resistant NVT...
  68. pmc Genetic basis for the new pneumococcal serotype, 6C
    In Ho Park
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South, BBRB 614, Birmingham, AL 35294, USA
    Infect Immun 75:4482-9. 2007
    ..These findings indicate that the 6C capsule type originated more than 27 years ago by a single recombination event in a 6A locus in which 6A wciN was replaced by a gene of unknown origin...
  69. ncbi Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children
    Angela B Brueggemann
    Academic Department of Microbiology and Infectious Disease, University of Oxford, Oxford, United Kingdom
    J Infect Dis 190:1203-11. 2004
    ..There was no evidence of any temporal change or major geographical differences in serotype- or serogroup-specific invasive disease potential...
  70. pmc The 13-valent pneumococcal conjugate vaccine (PCV13) elicits cross-functional opsonophagocytic killing responses in humans to Streptococcus pneumoniae serotypes 6C and 7A
    David Cooper
    Pfizer Vaccine Research, Pfizer, Pearl River, NY 10965, United States
    Vaccine 29:7207-11. 2011
    ..Taken together these results suggest that immunization with PCV13 has the potential to induce cross-protective responses to related serotypes not directly covered by the vaccine...
  71. doi Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains
    Elske J M van Gils
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Pediatric Immunology and Infectious Diseases, 3508 AB Utrecht, The Netherlands
    JAMA 304:1099-106. 2010
    ..Because spontaneous fluctuations in time and antibiotic selective pressure may have induced this serotype 19A increase, controlled studies are needed to assess the role of PCV-7...
  72. doi Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: England and Wales, 1996-2006
    Caroline L Trotter
    Department of Social Medicine, University of Bristol, Canynge Hall, UK
    J Infect 60:200-8. 2010
    ..To describe the epidemiology of invasive pneumococcal disease (IPD) in England & Wales in the pre-conjugate vaccine era...
  73. pmc Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors
    Mariacarmela Allocca
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Napoli, Italy
    J Virol 81:11372-80. 2007
    ....
  74. pmc Production of a unique pneumococcal capsule serotype belonging to serogroup 6
    Preston E Bratcher
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Microbiology 155:576-83. 2009
    ..Nevertheless, this study shows that this capsular PS is biochemically possible and could exist/emerge in nature...
  75. pmc Novel AAV serotypes for improved ocular gene transfer
    Corinna Lebherz
    Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Gene Med 10:375-82. 2008
    ..We show here that AAV7 and 8 enable superior long-term transduction of retinal and also anterior chamber structures...
  76. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    ..Our findings illustrate the uniqueness of each serotype in producing epidemics and severe disease and underscore the importance of long-term surveillance of dengue serotypes in understanding the epidemiology of these viruses...
  77. ncbi Analysis and phylogenetic comparisons of full-length VP2 genes of the 24 bluetongue virus serotypes
    S Maan
    Department of Arbovirology, Institute for Animal Health, Pirbright Laboratory, Ash Road, Woking, Surrey GU24 0NF, UK
    J Gen Virol 88:621-30. 2007
    ..The data presented form an initial basis for BTV serotype identification by sequence analyses and comparison of Seg-2, and for development of molecular diagnostic assays for individual BTV serotypes (by RT-PCR)...
  78. pmc Pneumococcal capsular polysaccharide structure predicts serotype prevalence
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    PLoS Pathog 5:e1000476. 2009
    ....
  79. pmc PCR-based quantitation and clonal diversity of the current prevalent invasive serogroup 6 pneumococcal serotype, 6C, in the United States in 1999 and 2006 to 2007
    Maria Da Gloria Carvalho
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 47:554-9. 2009
    ..1%), respectively. These results agreed with those from a previously devised monoclonal antibody-based serotyping system (346 CS6As compared)...
  80. doi Changing epidemiology of invasive pneumococcal disease in Canada, 1998-2007: update from the Calgary-area Streptococcus pneumoniae research (CASPER) study
    James D Kellner
    University of Calgary, Alberta Children s Hospital, Calgary Health Region, Calgary, Alberta, Canada
    Clin Infect Dis 49:205-12. 2009
    ..Routine infant vaccination with 7-valent pneumococcal conjugate vaccine (PCV7) began in the Calgary Health Region (Alberta, Canada) in 2002. We measured the impact of this vaccine program on invasive pneumococcal disease (IPD)...
  81. pmc Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion
    Orjan Samuelsen
    Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, N 9038 Tromsø, Norway
    Antimicrob Agents Chemother 54:346-52. 2010
    ..The findings suggest that both import of successful international clones and local clonal expansion contribute to the emergence of MBL-producing P. aeruginosa in Scandinavia...
  82. pmc Serotype-related variation in susceptibility to complement deposition and opsonophagocytosis among clinical isolates of Streptococcus pneumoniae
    Merit Melin
    National Institute for Health and Welfare, Department of Vaccination and Immune Protection, Helsinki, Finland
    Infect Immun 78:5252-61. 2010
    ....
  83. pmc Cost-effective real-time reverse transcriptase PCR (RT-PCR) to screen for Dengue virus followed by rapid single-tube multiplex RT-PCR for serotyping of the virus
    Yee Ling Lai
    National Environment Agency, Environmental Health Institute, 11 Biopolis Way, 06 05 08 Helios Block, Singapore 138667
    J Clin Microbiol 45:935-41. 2007
    ..The second RT-PCR assay is a duplex fluorogenic probe-based real-time RT-PCR for serotyping clinical samples for dengue viruses. The detection threshold of the probe-based RT-PCR format was 0...
  84. pmc Evaluation of the NS1 rapid test and the WHO dengue classification schemes for use as bedside diagnosis of acute dengue fever in adults
    Shera Chaterji
    Program in Emerging Infectious Diseases, Duke National University of Singapore NUS Graduate Medical School, Singapore
    Am J Trop Med Hyg 84:224-8. 2011
    ....
  85. pmc Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Epidemics 2:80-4. 2010
    ..For other serotypes, the future course of replacement disease remains to be determined...
  86. doi Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines
    Gail L Rodgers
    Scientific Affairs and Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA 19426, USA
    Vaccine 27:3802-10. 2009
    ....
  87. ncbi A molecular-capsular-type prediction system for 90 Streptococcus pneumoniae serotypes using partial cpsA-cpsB sequencing and wzy- or wzx-specific PCR
    Fanrong Kong
    Centre for Infectious Diseases and Microbiology CIDM, Institute of Clinical Pathology and Medical Research ICPMR, Westmead, NSW 2145, Australia
    J Med Microbiol 54:351-6. 2005
    ..Although further study of the relationship between MCT and CS is needed, this system now allows serotype or serogroup identification of 95 % of S. pneumoniae isolates...
  88. pmc Genetic relatedness of the Streptococcus pneumoniae capsular biosynthetic loci
    Angeliki Mavroidi
    Department of Infectious Disease Epidemiology, Imperial College London, Room G22, Old Medical School Building, St Mary s Hospital, Norfolk Place, London W2 1PG, United Kingdom
    J Bacteriol 189:7841-55. 2007
    ....
  89. doi Clonal dissemination of human isolates of Streptococcus suis serotype 14 in Thailand
    Anusak Kerdsin
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Tiwanon Road, Muang, Nonthaburi 11000, Thailand
    J Med Microbiol 58:1508-13. 2009
    ..Because serotype 14 is becoming a more common cause of S. suis infections in humans, diagnostic tests for serotype 14 should be performed in South-East Asian countries...
  90. doi Evaluation of sequential multiplex PCR for direct detection of multiple serotypes of Streptococcus pneumoniae from nasopharyngeal secretions
    Martin Antonio
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    J Med Microbiol 58:296-302. 2009
    ..0001). The multiplex PCR method identified significantly more serotypes than the latex/Quellung method if limited to the 29 serotypes (P=0.001 and P=0.014, respectively)...
  91. pmc Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes
    J A Carriço
    Grupo de Biomatemática, Istituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Rua da Quinta Grande 6 2780 156 Oeiras, Portugal
    J Clin Microbiol 44:2524-32. 2006
    ..All isolates were characterized by macrolide resistance phenotyping, T serotyping, emm sequence typing, and pulsed-field gel electrophoresis (PFGE), using SmaI or Cfr9I and SfiI...
  92. pmc The cps genes of Streptococcus suis serotypes 1, 2, and 9: development of rapid serotype-specific PCR assays
    H E Smith
    Department of Bacteriology, DLO Institute for Animal Science and Health, 8200 AB Lelystad, The Netherlands
    J Clin Microbiol 37:3146-52. 1999
    ..Therefore, these tests may facilitate control and eradication programs...
  93. ncbi Using cpsA-cpsB sequence polymorphisms and serotype-/group-specific PCR to predict 51 Streptococcus pneumoniae capsular serotypes
    Fanrong Kong
    Centre for Infectious Diseases and Microbiology CIDM, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Darcy Road, Westmead, New South Wales 2145, Australia
    J Med Microbiol 52:1047-58. 2003
    ..51 serotypes) and 276 recent clinical isolates were used to develop MCT and compare it with conventional serotyping (CS) (total 427 isolates)...
  94. pmc Vaccine escape recombinants emerge after pneumococcal vaccination in the United States
    Angela B Brueggemann
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 3:e168. 2007
    ..Vaccine escape by genetic recombination at the capsular locus has the potential to reduce PCV7 effectiveness in the longer term...
  95. pmc Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
    Infect Immun 78:716-25. 2010
    ..This might be one mechanism by which the capsular serotype can affect the relative invasiveness of different S. pneumoniae strains...
  96. pmc Identification of serotype in culture negative pneumococcal meningitis using sequential multiplex PCR: implication for surveillance and vaccine design
    Samir K Saha
    Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu Children Hospital, Dhaka, Bangladesh
    PLoS ONE 3:e3576. 2008
    PCR-based serotyping of Streptococcus pneumoniae has been proposed as a simpler approach than conventional methods, but has not been applied to strains in Asia where serotypes are diverse and different from other part of the world...
  97. ncbi Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 116:e408-13. 2005
    ..Analysis of colonizing serotypes among healthy children in the community provides critical data on such changes...
  98. pmc Streptococcus suis in humans, Thailand
    Daisuke Takamatsu
    Emerg Infect Dis 14:181-3. 2008
  99. ncbi The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions
    M Gottschalk
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, PO Box 5000, Saint Hyacinthe, Montreal, Quebec, Canada J2S 7C6
    Vet Microbiol 76:259-72. 2000
    ..Further studies to delineate the mechanisms through which S. suis induces meningitis will contribute to the development of potential therapies for S. suis infections...
  100. pmc Serotyping Streptococcus pneumoniae by multiplex PCR
    D A Brito
    Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Oeiras, Portugal
    J Clin Microbiol 41:2378-84. 2003
    ..Capsular types identified by the PCR method invariably produced results concordant with the conventional serotyping technique...
  101. ncbi Sequential multiplex PCR for identifying pneumococcal capsular serotypes from South-Saharan African clinical isolates
    Luis Morais
    Centro de Investigação em Saúde da Manhiça CISM, Ministerio de Saude, CP1929 Maputo, Mozambique
    J Med Microbiol 56:1181-4. 2007
    A serial multiplex PCR approach was reformulated for pneumococcal serotyping to test 153 clinical isolates from children in Mozambique. This approach identified serotypes in 139 (90.8%) of 153 isolates; 126 (82...

Research Grants74

  1. OUTER MEMBRANE PROTEINS OF NONTYPEABLE H. INFLUENZAE
    Timothy Murphy; Fiscal Year: 1993
    ..antigenic differences and to raise monoclonal antibodies to determinants on P2 for the purpose of developing a serotyping system. A serotyping system for nontypeable H...
  2. GENETIC BASIS OF PEANUT ALLERGY
    Scott Sicherer; Fiscal Year: 2004
    ..twin pairs; 2) Since HLA class II molecules are an attractive candidate as one determinant for peanut allergy, serotyping will be performed and genotype frequencies compared for evidence of association in families with affected ..
  3. CLONAL DIVERSITY OF ORAL PATHOGENS
    C Chen; Fiscal Year: 2003
    ..actinomycetemcomitans and E. corrodens clones recovered from health and disease by serotyping, AP-PCR genotyping and mutilocus enzyme typing...
  4. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2007
    ..The major outer membrane protein (MOMP) of CT is an immunodominant protein and the primary target for serotyping, and hence strain typing along with the ompA gene, which encodes MOMP...
  5. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2007
    ..The major outer membrane protein (MOMP) of CT is an immunodominant protein and the primary target for serotyping, and hence strain typing along with the ompA gene, which encodes MOMP...
  6. Role of Enterococcal Polysaccharides in Virulence
    Johannes Huebner; Fiscal Year: 2006
    ..The development of a serotyping system for enterococci will be the necessary basis for the application of these antigens to immunotherapy and ..
  7. Microarray-based detection and typing of rhinoviruses
    Homer Boushey; Fiscal Year: 2005
    ..The PPG's Virology Core (California State Virology Laboratory, VRDL) performs RV serotyping, and has most RV prototypes and multiple isolates for specific serotypes...
  8. Genetic Resistance to Oncogenic Human Papillomaviruses
    Stephen Tyring; Fiscal Year: 2004
    ..For those women with antibodies to HPV-16 and/or -18, but who have no HPV DNA and a negative Pap smear, HLA serotyping will be done using the lymphocytes from the vial of blood...
  9. Post-PCV pneumococcal population genetics and resistance
    Jonathan Finkelstein; Fiscal Year: 2007
    ..Isolates will undergo resistance testing, serotyping, pulse field gel electrophoresis, and multi-locus sequence typing to determine the biological processes which ..
  10. Post-PCV pneumococcal population genetics and resistance
    Jonathan Finkelstein; Fiscal Year: 2009
    ..Isolates will undergo resistance testing, serotyping, pulse field gel electrophoresis, and multi-locus sequence typing to determine the biological processes which ..
  11. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  12. Infectious Disease Training in Clinical Investigation
    James Johnson; Fiscal Year: 2007
    ....
  13. Forensic Detection of Salmonella Resistance and Subtype
    Lee Harrison; Fiscal Year: 2005
    ..enterica and 2) molecular methods for rapid outbreak detection among S. enterica serovars. ..
  14. Shedding of HIV In Semen Despite Antiretroviral Therapy
    Lee Harrison; Fiscal Year: 2006
    ..abstract_text> ..
  15. Genomic Comparison of A. actinomycetemcomitans Strains
    C Chen; Fiscal Year: 2009
    ..The results are likely to further the progress in the field of periodontal disease pathogenesis. ..