serotyping

Summary

Top Publications

  1. ncbi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
  2. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
  3. pmc Serotype replacement in disease after pneumococcal vaccination
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:1962-73. 2011
  4. ncbi Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London, UK
    Lancet Infect Dis 11:760-8. 2011
  5. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
  6. pmc Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes
    Stephen D Bentley
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 2:e31. 2006
  7. pmc Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates
    Rekha Pai
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 44:124-31. 2006
  8. pmc The 13-valent pneumococcal conjugate vaccine (PCV13) elicits cross-functional opsonophagocytic killing responses in humans to Streptococcus pneumoniae serotypes 6C and 7A
    David Cooper
    Pfizer Vaccine Research, Pfizer, Pearl River, NY 10965, United States
    Vaccine 29:7207-11. 2011
  9. ncbi Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
  10. ncbi Leptospirosis
    Alan J A McBride
    Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Rua Waldemar Falcao 121, 40295 001 Salvador, Bahia, Brazil
    Curr Opin Infect Dis 18:376-86. 2005

Detail Information

Publications296 found, 100 shown here

  1. ncbi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
    ..Changes in invasive pneumococcal disease (IPD) incidence were evaluated after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children...
  2. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
    ..6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type...
  3. pmc Serotype replacement in disease after pneumococcal vaccination
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:1962-73. 2011
    ..We conclude by discussing the future potential for serotype replacement in disease and the need for continuing surveillance...
  4. ncbi Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London, UK
    Lancet Infect Dis 11:760-8. 2011
    ..We assess the effect of the PCV7 vaccination on VT and NVT disease in England and Wales...
  5. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
    ....
  6. pmc Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes
    Stephen D Bentley
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 2:e31. 2006
    ..of the genetics and origins of bacterial polysaccharide diversity, laying the foundations for molecular serotyping. This is the first time, to our knowledge, that a complete repertoire of capsular biosynthetic genes has been ..
  7. pmc Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates
    Rekha Pai
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 44:124-31. 2006
    Accurate serotyping is essential to monitor the changes in the seroepidemiology of Streptococcus pneumoniae...
  8. pmc The 13-valent pneumococcal conjugate vaccine (PCV13) elicits cross-functional opsonophagocytic killing responses in humans to Streptococcus pneumoniae serotypes 6C and 7A
    David Cooper
    Pfizer Vaccine Research, Pfizer, Pearl River, NY 10965, United States
    Vaccine 29:7207-11. 2011
    ..Taken together these results suggest that immunization with PCV13 has the potential to induce cross-protective responses to related serotypes not directly covered by the vaccine...
  9. ncbi Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
    ....
  10. ncbi Leptospirosis
    Alan J A McBride
    Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Rua Waldemar Falcao 121, 40295 001 Salvador, Bahia, Brazil
    Curr Opin Infect Dis 18:376-86. 2005
    ..This review addresses the issues in the epidemiology, diagnosis and clinical management which confront public health responses, and highlights the progress made towards understanding the Leptospira genome, biology and pathogenesis...
  11. ncbi Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group
    S Black
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 19:187-95. 2000
    ....
  12. pmc Impact of more than a decade of pneumococcal conjugate vaccine use on carriage and invasive potential in Native American communities
    Jennifer R Scott
    Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 205:280-8. 2012
    ..We assessed the impact of 12 years of pneumococcal conjugate vaccine (PCV7) use on pneumococcal nasopharyngeal carriage and serotype-specific invasive disease potential among Native Americans...
  13. ncbi Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential
    Angela B Brueggemann
    Academic Department of Microbiology and Infectious Disease, John Radcliffe Hospital and Department of Public Health and Primary Care, University of Oxford, Oxford, United Kingdom
    J Infect Dis 187:1424-32. 2003
    ....
  14. pmc Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray
    Paul Turner
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    J Clin Microbiol 49:1784-9. 2011
    ..Conventional nasopharyngeal swab (NPS) culture and serotyping (the WHO protocol) is likely to underestimate multiple-serotype carriage...
  15. ncbi Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae
    Moe H Kyaw
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 354:1455-63. 2006
    ..We examined the effect of this vaccine on invasive disease caused by resistant strains...
  16. ncbi Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 368:1495-502. 2006
    ..Our aim was to assess the effectiveness of the vaccine against various pneumococcal serotypes, and to measure the effectiveness of the recommended dose schedule and of catch-up and incomplete schedules...
  17. ncbi A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection
    Keith P Klugman
    Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
    N Engl J Med 349:1341-8. 2003
    ..We evaluated the efficacy of a 9-valent pneumococcal conjugate vaccine in a randomized, double-blind study in Soweto, South Africa...
  18. ncbi Molecular epidemiology of foot-and-mouth disease virus
    N J Knowles
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK nick knowles bbsrc ac uk
    Virus Res 91:65-80. 2003
    ..An increased understanding of how FMDV strains move between geographic regions will play a pivotal role in the development of future disease control strategies...
  19. pmc Microevolution and virulence of dengue viruses
    Rebeca Rico-Hesse
    Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Adv Virus Res 59:315-41. 2003
    ....
  20. pmc Multilocus sequence typing as a replacement for serotyping in Salmonella enterica
    Mark Achtman
    Environmental Research Institute and Department of Microbiology, University College Cork, Cork, Ireland
    PLoS Pathog 8:e1002776. 2012
    ..An inability of serotyping to correctly group isolates was most apparent for Paratyphi B and its variant Java...
  21. ncbi Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 348:1737-46. 2003
    ..In early 2000, a protein-polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children...
  22. ncbi Temporal trends in invasive pneumococcal disease and pneumococcal serotypes over 7 decades
    Zitta B Harboe
    National Neisseria and Streptococcus Reference Center, Department of Bacteriology, Mycology, and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    Clin Infect Dis 50:329-37. 2010
    ..We explored historical trends of invasive pneumococcal disease (IPD) and pneumococcal serotypes in a population exposed to limited antibiotic selective pressure and conjugate pneumococcal vaccination (PCV)...
  23. pmc Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study
    Stefan Flasche
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS Med 8:e1001017. 2011
    ....
  24. pmc Cost-effective real-time reverse transcriptase PCR (RT-PCR) to screen for Dengue virus followed by rapid single-tube multiplex RT-PCR for serotyping of the virus
    Yee Ling Lai
    National Environment Agency, Environmental Health Institute, 11 Biopolis Way, 06 05 08 Helios Block, Singapore 138667
    J Clin Microbiol 45:935-41. 2007
    ..The second RT-PCR assay is a duplex fluorogenic probe-based real-time RT-PCR for serotyping clinical samples for dengue viruses. The detection threshold of the probe-based RT-PCR format was 0...
  25. pmc Clades of Adeno-associated viruses are widely disseminated in human tissues
    Guangping Gao
    Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, 3601 Spruce Street, Philadelphia, PA 19104, USA
    J Virol 78:6381-8. 2004
    ..These data provide important information regarding the biology of parvoviruses in humans and their use as gene therapy vectors...
  26. ncbi Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity
    Martin C J Maiden
    Dept of Zoology, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom
    J Infect Dis 197:737-43. 2008
    ..The impact of this intervention on asymptomatic carriage of meningococci was investigated to establish whether serogroup replacement or protection by herd immunity occurred...
  27. ncbi Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
    ..pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques...
  28. pmc A new pneumococcal serotype, 11E, has a variably inactivated wcjE gene
    Juan J Calix
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Infect Dis 202:29-38. 2010
    ..We propose to name the 11Aalpha subtype as serotype 11A and the 11Abeta subtype as 11E, a new serotype. Our findings also suggest that the diversity of pneumococcal capsules is much greater than was previously recognized...
  29. ncbi The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli; under-rated pathogens
    Karl A Bettelheim
    Crit Rev Microbiol 33:67-87. 2007
    ..The animal host-specificity of these STEC is also reviewed. In conclusion some methods of improving isolation of these pathogens is addressed...
  30. ncbi Enterovirus surveillance--United States, 1970-2005
    Nino Khetsuriani
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases proposed, CDC, 1600 Clifton Road, NE, MS A 34, Atlanta, Georgia 30333, USA
    MMWR Surveill Summ 55:1-20. 2006
    ..Individual serotypes have different temporal patterns of circulation and often are associated with different clinical manifestations. Changes in circulating serotypes might be accompanied by large-scale outbreaks...
  31. pmc Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study
    Zitta B Harboe
    Department of Bacteriology, Statens Serum Institut, Copenhagen
    PLoS Med 6:e1000081. 2009
    ..Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD)...
  32. pmc Differential effects of pneumococcal vaccines against serotypes 6A and 6C
    In H Park
    Departments of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Infect Dis 198:1818-22. 2008
    Because classic pneumococcal serotyping methods cannot distinguish between serotypes 6A and 6C, the effects of pneumococcal vaccines against serotype 6C are unknown. Pneumococcal vaccines contain serotype 6B but not serotypes 6A and 6C.
  33. ncbi Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003
    Richard A Adegbola
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Trop Med Int Health 11:1128-35. 2006
    ..To describe the characteristics of pneumococcal isolates obtained from patients with invasive pneumococcal disease in The Gambia...
  34. ncbi Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    Clin Infect Dis 50:1468-76. 2010
    ..pneumoniae in rural Africa and a baseline for evaluating the impact of the introduction of pneumococcal conjugate vaccine into the region...
  35. ncbi Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990-2007
    Tami H Skoff
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:85-92. 2009
    ..We used population-based surveillance to examine trends in adult GBS disease during the period 1990-2007 and to describe the epidemiology of adult GBS disease to guide prevention efforts...
  36. ncbi Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 45:284-93. 2007
    ..There are limited data regarding the role of bacterial genotype in the pathogenesis of this syndrome...
  37. pmc Comparison of classic and molecular approaches for the identification of untypeable enteroviruses
    M S Oberste
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:1170-4. 2000
    ..RT-PCR, coupled with amplicon sequencing, is a simple and rapid method for the typing and classification of picornaviruses and may lead to the identification of many new picornavirus serotypes...
  38. pmc Genetic diversity among Botulinum Neurotoxin-producing clostridial strains
    K K Hill
    Bioscience, Theoretical Divisions, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    J Bacteriol 189:818-32. 2007
    ..These analyses contribute to the understanding of the evolution and phylogeny within this species and assist in the development of improved diagnostics and therapeutics for the treatment of botulism...
  39. ncbi An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 192:192-9. 2005
    ..These epidemics are generally caused by Neisseria meningitidis, an organism that is considered to be uniquely capable of causing meningitis epidemics...
  40. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Clin Infect Dis 43:673-9. 2006
    ..To prepare for the introduction of a pneumococcal conjugate vaccine of restricted valency, we studied the nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers...
  41. pmc Denmark14-230 clone as an increasing cause of pneumococcal infection in Portugal within a background of diverse serotype 19A lineages
    Sandra I Aguiar
    Instituto de Microbiologia, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    J Clin Microbiol 48:101-8. 2010
    ....
  42. pmc Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes
    Sarah Cobey
    Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Science 335:1376-80. 2012
    ..Our model can be used to explain the effects of pneumococcal vaccination and indicates general factors that regulate the diversity of pathogens...
  43. ncbi Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines
    Daniel J Isaacman
    Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA, USA
    Int J Infect Dis 14:e197-209. 2010
    ..The overall reported burden of invasive pneumococcal disease (IPD) varies among countries in Europe. This review describes the epidemiology and serotype distribution of IPD in European children from studies published from 1990 to 2008...
  44. ncbi Serotype prevalence in adults hospitalised with pneumococcal non-invasive community-acquired pneumonia
    Thomas Bewick
    Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham NG5 1PB, UK
    Thorax 67:540-5. 2012
    ..The distribution of pneumococcal serotypes implicated in non-invasive community-acquired pneumonia (CAP) in adults is currently unknown...
  45. pmc Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands
    Judith Spijkerman
    University Medical Center, Utrecht, The Netherlands
    Emerg Infect Dis 17:584-91. 2011
    ..PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination...
  46. ncbi Non-O157 Shiga toxin-producing Escherichia coli infections in the United States, 1983-2002
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:1422-9. 2005
    ..Non-O157 STEC contribute to this burden of illness but have been underrecognized as a result of diagnostic limitations and inadequate surveillance...
  47. ncbi Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children
    Angela B Brueggemann
    Academic Department of Microbiology and Infectious Disease, University of Oxford, Oxford, United Kingdom
    J Infect Dis 190:1203-11. 2004
    ..There was no evidence of any temporal change or major geographical differences in serotype- or serogroup-specific invasive disease potential...
  48. ncbi Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
    Lauri A Hicks
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1346-54. 2007
    ..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
  49. pmc Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Infect Dis 51:692-9. 2010
    ..We evaluated whether risk of death due to IPD is a stable serotype-associated property across studies and then compared the pooled effect estimates with epidemiologic and biological correlates...
  50. ncbi Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia
    Kai Hu Yao
    Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing, China
    Vaccine 29:2296-301. 2011
    ..The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A...
  51. pmc Clustering of serotypes in a longitudinal study of Streptococcus pneumoniae carriage in three day care centres
    Tuija Leino
    National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    BMC Infect Dis 8:173. 2008
    ..Here we report the first longitudinal study of pneumococcal carriage that records serotype specific exposure to pneumococci simultaneously within the two most important mixing groups, families and day care facilities...
  52. ncbi Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal nasopharyngeal carriage in children with acute otitis media
    Robert Cohen
    ACTIV Association Clinique et Thérapeutique Infantile du Val de Marne, Paris, France
    Pediatr Infect Dis J 31:297-301. 2012
    ..This program was used in 2010-2011 to assess the effect of the implementation of PCV13 on PNP carriage in young children with AOM...
  53. ncbi Genetic analysis of meningococci carried by children and young adults
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Infect Dis 191:1263-71. 2005
    ..The relationship between meningococcal genotype and capsular polysaccharide, the principal virulence factor and vaccine component, was investigated in carried meningococci isolated from 8000 children and young adults in Bavaria, Germany...
  54. pmc Simple, rapid latex agglutination test for serotyping of pneumococci (Pneumotest-Latex)
    H C Slotved
    Serum Production Unit, Department of Bacteriology, Mycology and Parasitology, Division of Microbiology and Diagnostics, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Clin Microbiol 42:2518-22. 2004
    ..e., serotyping. The method is labor intensive and requires a certain level of experience to be performed satisfactory, and thus ..
  55. pmc AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method
    Ronald L Klein
    Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Mol Ther 16:89-96. 2008
    ..The purification method can therefore impact the transduction pattern as well as the results when comparing serotype strengths...
  56. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
    ..This study assessed the efficacy of a novel vaccine that contained polysaccharides from 11 different Streptococcus pneumoniae serotypes each conjugated to Haemophilus influenzae-derived protein D in prevention of acute otitis media...
  57. pmc Pneumococcal capsular polysaccharide structure predicts serotype prevalence
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    PLoS Pathog 5:e1000476. 2009
    ....
  58. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
    ....
  59. pmc SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2
    Ming Li
    Department of Microbiology, Third Military Medical University, Chongqing, China
    PLoS ONE 3:e2080. 2008
    ..However, the molecular pathogenesis of this new emerging pathogen is still poorly understood...
  60. pmc A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting
    M Hussain
    Immunisation Department, Communicable Disease Surveillance Centre, Health Protection Agency Centre for Infections, London, UK
    Epidemiol Infect 133:891-8. 2005
    ..pneumoniae is common in a UK setting in the pre-conjugate vaccine era. PCV would protect against a large proportion of carriage isolates. However, the impact of vaccination on non-vaccine serotypes will need to be monitored...
  61. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia
    Clin Infect Dis 46:807-14. 2008
    ..To prepare for national introduction of a pneumococcal conjugate vaccine of restricted valency, we studied nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants...
  62. ncbi Serotype-specific differences in clinical manifestations of dengue
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Managua, Nicaragua
    Am J Trop Med Hyg 74:449-56. 2006
    ..86, CI 2.72-5.48) and more primary DENV infections with severe manifestations (OR 2.93, CI 2.00-4.28). These findings provide new data to characterize the pathogenic potential of distinct DENV serotypes in human populations...
  63. pmc Continued impact of pneumococcal conjugate vaccine on carriage in young children
    Susan S Huang
    Division of Infectious Diseases, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Pediatrics 124:e1-11. 2009
    ....
  64. pmc Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae
    In Ho Park
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 614, Birmingham, AL 35294, USA
    J Clin Microbiol 45:1225-33. 2007
    ..This study also demonstrates that a new serotype may exist within an established and well-characterized serogroup or serotype...
  65. ncbi A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
    Microbiology 144:3049-60. 1998
    ..A Web site for the molecular characterization of pneumococci by MLST is available (http ://mlst.zoo.ox.ac.uk)...
  66. ncbi Global monitoring of Salmonella serovar distribution from the World Health Organization Global Foodborne Infections Network Country Data Bank: results of quality assured laboratories from 2001 to 2007
    Rene S Hendriksen
    National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and Community Reference Laboratory for Antimicrobial Resistance, Technical University of Denmark, Copenhagen, Denmark
    Foodborne Pathog Dis 8:887-900. 2011
    ..Interventions are needed to control Salmonella; subtyping Salmonella by serotyping is useful for targeting such interventions...
  67. pmc Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
    J C Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    Clin Microbiol Rev 11:450-79. 1998
    ..This, in turn, has created a potential window of opportunity for future therapeutic intervention...
  68. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..However, the relationship between the clinical presentation and bacterial factors remains unclear. The aim of this study was to investigate the clinical features of patients and the serotype and ribotype of K pneumoniae liver abscess...
  69. pmc The prevalence and risk factors for pneumococcal colonization of the nasopharynx among children in Kilifi District, Kenya
    Osman Abdullahi
    Wellcome Trust Research Program, Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 7:e30787. 2012
    ..We studied the epidemiology of carriage among children 3-59 months old before vaccine introduction in Kilifi, Kenya...
  70. ncbi Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  71. ncbi Serotypes and genotypes of Streptococcus pneumoniae causing pneumonia and acute exacerbations in patients with chronic obstructive pulmonary disease
    Arnau Domenech
    Microbiology Department, Hospital Universitari de Bellvitge IDIBELL, Barcelona, Spain
    J Antimicrob Chemother 66:487-93. 2011
    ..This study aimed to compare the antibiotic susceptibilities, serotypes and genotypes of pneumococci causing pneumonia or acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in patients with COPD...
  72. ncbi Pre- and post-conjugate vaccine epidemiology of pneumococcal serotype 6C invasive disease and carriage within Navajo and White Mountain Apache communities
    Eugene V Millar
    Johns Hopkins Center for American Indian Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin Infect Dis 51:1258-65. 2010
    ..The epidemiology of serotype 6C prior to and after 7-valent PCV (PCV7) introduction is incompletely understood...
  73. pmc Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Epidemics 2:80-4. 2010
    ..For other serotypes, the future course of replacement disease remains to be determined...
  74. ncbi Current epidemiology and trends in invasive Haemophilus influenzae disease--United States, 1989-2008
    Jessica R MacNeil
    Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 53:1230-6. 2011
    ..With the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines, there has been a dramatic reduction of Hib disease in young children and the epidemiological trends of invasive H. influenzae have shifted...
  75. pmc Identification of natural pneumococcal isolates expressing serotype 6D by genetic, biochemical and serological characterization
    Preston E Bratcher
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Microbiology 156:555-60. 2010
    ..However, we now report the discovery of two naturally occurring pneumococcal isolates from Korea that have the serological, genetic and biochemical features predicted for serotype 6D...
  76. pmc Establishment of a universal size standard strain for use with the PulseNet standardized pulsed-field gel electrophoresis protocols: converting the national databases to the new size standard
    Susan B Hunter
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop C03, Atlanta, GA 30333, USA
    J Clin Microbiol 43:1045-50. 2005
    ..The strategy used to convert and compare data generated by the new and old reference standards is described...
  77. ncbi Meningococcal meningitis: unprecedented incidence of serogroup X-related cases in 2006 in Niger
    Pascal Boisier
    centre de recherche médicale et sanitaire, Réseau International des Instituts Pasteur, Niamey, Niger
    Clin Infect Dis 44:657-63. 2007
    ..However, since 2002, Nm serogroup W135 has been considered to be a major threat that has not yet been realized, and an unprecedented incidence of Nm serogroup X (NmX) meningitis was observed in 2006...
  78. pmc 7-Valent pneumococcal conjugate vaccination in England and Wales: is it still beneficial despite high levels of serotype replacement?
    Yoon Hong Choi
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS ONE 6:e26190. 2011
    ..However, recent surveillance data show a more rapid replacement of PCV7 IPD cases by non-PCV7 IPD cases than was seen in the US...
  79. pmc Serotype-specific detection of dengue viruses in a fourplex real-time reverse transcriptase PCR assay
    Barbara W Johnson
    Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort, Collins, CO 80521
    J Clin Microbiol 43:4977-83. 2005
    ..reverse transcriptase PCR nucleic acid detection assay can be used as a method for differential diagnosis of a specific DEN serotype in viremic dengue patients and as a tool for rapid identification and serotyping of DEN virus isolates.
  80. pmc Characterization of culture-positive adenovirus serotypes from respiratory specimens in Toronto, Ontario, Canada: September 2007-June 2008
    Rani Yeung
    Ministry of Health and Long Term Care, Public Health Laboratories Branch, Etobicoke, Ontario, Canada
    Virol J 6:11. 2009
    ..Molecular methods allow for the determination of circulating adenovirus serotypes and be used to document the spread of highly virulent adenoviral serotypes into a region...
  81. pmc Carried pneumococci in Massachusetts children: the contribution of clonal expansion and serotype switching
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Pediatr Infect Dis J 30:302-8. 2011
    ..Vaccination against 7 serotypes of Streptococcus pneumoniae has led to the near extinction of vaccine serotypes in both disease and asymptomatic carriage. In carriage, vaccine serotypes have been replaced by nonvaccine serotypes...
  82. ncbi Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination
    H J Adam
    Department of Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Vaccine 28:4073-8. 2010
    ..Health Laboratories-Toronto, Ontario Agency for Health Protection and Promotion, which performed almost all serotyping on invasive (blood, CSF, other sterile sites) H...
  83. ncbi Effectiveness of the new serotypes in the 13-valent pneumococcal conjugate vaccine
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Services, Colindale, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    Vaccine 29:9127-31. 2011
    ..VE for serotypes 1 and 3 was 62% and 66% respectively although confidence intervals spanned zero. IPD due to PCV13-only serotypes halved in children under 2 years in the study period...
  84. ncbi Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nature 413:848-52. 2001
    ..typhi. CT18 harbours a 218,150-bp multiple-drug-resistance incH1 plasmid (pHCM1), and a 106,516-bp cryptic plasmid (pHCM2), which shows recent common ancestry with a virulence plasmid of Yersinia pestis...
  85. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    ....
  86. pmc Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease
    Alessia Melegaro
    DONDENA Centre for Research on Social Dynamics, Bocconi University, Via Guglielmo Rontgen, Milan, Italy
    BMC Infect Dis 10:90. 2010
    ..However the long term effects of PCV are still unclear, as beneficial direct and herd immunity effects might be countered by serotype replacement...
  87. pmc Capsular polysaccharide synthesis regions in Klebsiella pneumoniae serotype K57 and a new capsular serotype
    Yi Jiun Pan
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Clin Microbiol 46:2231-40. 2008
    ..PCR using primers from specific genes for K57 was more sensitive and specific than traditional serotyping. The remaining strain, A1517, did not react to the antisera from any of the 77 serotypes, and none of the 77 ..
  88. ncbi Epidemiological and molecular characteristics of a highly lethal pneumococcal meningitis epidemic in Burkina Faso
    Seydou Yaro
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    Clin Infect Dis 43:693-700. 2006
    ..Public health and clinical strategies for meningitis epidemics in sub-Saharan Africa usually assume that Neisseria meningitidis infection causes most disease...
  89. pmc Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine
    Silvio D Brugger
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    PLoS ONE 5:e11638. 2010
    ..We studied the epidemiology of cocolonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal vaccine (PCV7)...
  90. pmc Streptococcus pneumoniae serotype 19A in children, South Korea
    Eun Hwa Choi
    Seoul National University College of Medicine, Seoul, South Korea
    Emerg Infect Dis 14:275-81. 2008
    ..005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use...
  91. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  92. ncbi Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo
    Christina A Pacak
    Center for Fetal Monkey Gene Transfer for Heart, Lung and Blood Diseases, California National Primate Research Center, Davis, USA
    Circ Res 99:e3-9. 2006
    ....
  93. ncbi Invasive disease and paediatric carriage of Streptococcus pneumoniae in Ghana
    Eric S Donkor
    Department of Microbiology, University of Ghana Medical School, Accra, Ghana
    Scand J Infect Dis 42:254-9. 2010
    ..Invasive and nasopharyngeal specimens were screened for S. pneumoniae, and isolates were subjected to serotyping, multilocus sequence typing (MLST) and antibiotic susceptibility testing. Overall, the prevalence of S...
  94. ncbi First report of putative Streptococcus pneumoniae serotype 6D among nasopharyngeal isolates from Fijian children
    Ping Jin
    Bao an Maternity and Child Health Hospital, Shenzhen, People s Republic of China
    J Infect Dis 200:1375-80. 2009
    ..A putative Streptococcus pneumoniae serotype, 6D, resulting from the introduction of wciN(beta) into serotype 6B has been proposed...
  95. pmc Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministry of Health, Nicaragua
    J Infect Dis 201:5-14. 2010
    ..Dengue is the most prevalent mosquito-borne viral disease in humans and a major urban public health problem worldwide...
  96. pmc The descriptive epidemiology of Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal carriage in children and adults in Kilifi district, Kenya
    Osman Abdullahi
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatr Infect Dis J 27:59-64. 2008
    ..In East Africa we do not know how these pathogens are transmitted between population subgroups nor which serotypes circulate commonly...
  97. ncbi Capsular serotype-specific attack rates and duration of carriage of Streptococcus pneumoniae in a population of children
    Karen L Sleeman
    University Department of Paediatrics, Oxford Vaccine Group, John Radcliffe Hospital, University of Oxford, Headington, Oxford, OX3 9DU, United Kingdom
    J Infect Dis 194:682-8. 2006
    ....
  98. ncbi Supplement 2003-2007 (No. 47) to the White-Kauffmann-Le Minor scheme
    Martine Guibourdenche
    Institut Pasteur, WHO Collaborating Center for Reference and Research on Salmonella, Unité de Biodiversité des Bactéries Pathogènes Emergentes, Paris, France
    Res Microbiol 161:26-9. 2010
    ..One new serovar, Mygdal, displayed a new H factor, H:z(91)...
  99. ncbi Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccine
    R Sá-Leão
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Clin Microbiol Infect 15:1002-7. 2009
    ..Rates of antibiotic resistance remained unchanged due to a balance between reduction in VT and an increase in antimicrobial-resistant NVT...
  100. ncbi Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial
    Elske J M van Gils
    Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children s Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    JAMA 302:159-67. 2009
    ..The effects of reduced-dose schedules of 7-valent pneumococcal conjugate vaccine (PCV-7) on pneumococcal carriage in children are largely unknown, although highly relevant in the context of subsequent herd effects...
  101. ncbi Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
    Timothy P Endy
    Division of Virology, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Materiel Command, Ft Detrick, Maryland, USA
    J Infect Dis 189:990-1000. 2004
    ..Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood...

Research Grants62

  1. GENETIC BASIS OF PEANUT ALLERGY
    Scott Sicherer; Fiscal Year: 2004
    ..twin pairs; 2) Since HLA class II molecules are an attractive candidate as one determinant for peanut allergy, serotyping will be performed and genotype frequencies compared for evidence of association in families with affected ..
  2. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets
    Timothy S Frana; Fiscal Year: 2012
    ..Patient fecal samples will be cultured for Salmonella from using well established and validated methods. Serotyping methods will also be standardized among the participants...
  3. GH13-006: RESEARCH AND TECHNICAL ASSISTANCE FO REPUBLIC HEALTH INT
    WEDNER PIERRE; Fiscal Year: 2013
    ..from 0 to 5 years of age and collecting nasopharyngeal specimens to be tested via isolation and conventional serotyping methods at the National Public Health Reference lab in Port-au-Prince...
  4. Epidemiology of Community-Associated, ESBL-Producing Escherichia coli
    Yohei Doi; Fiscal Year: 2010
    ..Susceptibility testing, PCR and sequencing of ESBL genes, pulsed-field gel electrophoresis, MLST, phylotyping, serotyping and plasmid analysis will then be performed at the central laboratory...
  5. Development of a Laboratory Quality Management System for Food Testing to Meet th
    JACK R MORGAN; Fiscal Year: 2013
    ..The identification of the bacteria is completed by the use of serotyping and Pulsed Field Gel Electrophoresis (PFGE)...
  6. FDA FERN Microbiological Cooperative Agreement Program Renewal
    PETE WILLIAM DOMBROSKI; Fiscal Year: 2013
    ..will continue to use methods already in place such as traditional culture and biochemical identification, serotyping, and pulsed-field gel electrophoresis...
  7. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets_ Study for the VetL
    DAVID HENRY ZEMAN; Fiscal Year: 2012
    ..Also serological identification tests for Salmonella will be performed. Finally, for serotyping and classification on subspecies level, the isolates will be forwarded to NVSL (National Veterinary Service ..
  8. Enhanced Suveillance for New Vaccine Preventable Diseases
    Parvin H Azimi; Fiscal Year: 2013
    ..All stool samples demonstrating a positive result will be forwarded to CDC, for serotyping. Saliva samples will be obtained in a portion of AGE cases for determination of norovirus-secretor status...
  9. LEWIS ANTIGEN EXPRESSION AND PATHOGENESIS OF H PYORI
    JOANNA GOLDBERG; Fiscal Year: 2000
    ..Specifically, a serotyping system for H...
  10. CAMPYLOBACTER PYLORI IN GASTROINTESTINAL DISEASE
    JOHN PENNER; Fiscal Year: 1990
    ..animal models are not available and epidemiological studies have been hindered by the lack of a system for serotyping the strains...
  11. Role of Enterococcal Polysaccharides in Virulence
    Johannes Huebner; Fiscal Year: 2006
    ..The development of a serotyping system for enterococci will be the necessary basis for the application of these antigens to immunotherapy and ..
  12. SUBGROUPS OF NEISSERIA GONORRHOEAE
    Michael Apicella; Fiscal Year: 1980
    ..of carefully defined gonococal strains to compare the relationship between Gc antigens and other gonococcal serotyping systems...
  13. VIRULENCE OF A LINEAGE OF UROPATHOGENIC ESCHERICHIA COLI
    James Johnson; Fiscal Year: 2000
    ..characteristics through the use of polymerase chain reaction- (PCR-) based genomic ifingerprinting, O:K:H;F serotyping, and PCR-based detection of the three papG alleles and genes for cytotoxic necrotizing factor 1 (chf1) and ..
  14. VACCINATION FOR HIV AND AIDS
    MURRAY GARDNER; Fiscal Year: 1993
    ..1) To compare several HIV-1 strains, selected on the basis of clinical features, biologic properties and serotyping, for toxicity and immunogenicity in guinea pigs and rhesus macaques...
  15. TAXONOMIC STUDIES OF PATHOGENIC MENINGOCOCCI
    Michael Apicella; Fiscal Year: 1980
    ..from pathogenic meningococci (serogroups A, B, C, X and Y) with the goal of developing a comprehensive LPS based serotyping system for these meningococci...
  16. Microarray-based detection and typing of rhinoviruses
    Homer Boushey; Fiscal Year: 2005
    ..The PPG's Virology Core (California State Virology Laboratory, VRDL) performs RV serotyping, and has most RV prototypes and multiple isolates for specific serotypes...
  17. Genetic Resistance to Oncogenic Human Papillomaviruses
    Stephen Tyring; Fiscal Year: 2004
    ..For those women with antibodies to HPV-16 and/or -18, but who have no HPV DNA and a negative Pap smear, HLA serotyping will be done using the lymphocytes from the vial of blood...
  18. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  19. IDENTIFYING EPITOPES THAT DEFINE SEROTYPES OF HIV1
    Phillipe Nyambi; Fiscal Year: 1999
    ..AIM 2, to define clusters of viruses that are related immunologically (serotypes), to define the epitopes common to these serotypes, and to identify mAbs that can be used in serotyping HIV 1 isolates.
  20. Forensic Detection of Salmonella Resistance and Subtype
    Lee Harrison; Fiscal Year: 2005
    ..enterica and 2) molecular methods for rapid outbreak detection among S. enterica serovars. ..
  21. Mechanisms of Tandem Repeat Deletion in Group B Strep
    KAREN PUOPOLO; Fiscal Year: 2006
    ..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..
  22. Pneumococcal conjugate vaccines and old adults
    MOON NAHM; Fiscal Year: 2009
    ..This study will enhance the knowledge of pneumococcal antibodies made by old adults and will help us determine if PCVs can be useful in pneumococcal vaccination of old adults, a major goal of our national health care policy. ..
  23. PREVENTION OF PNEUMOCOCCAL DISEASE IN HIV INFECTION
    MARY MCELLISTREM; Fiscal Year: 2004
    ..All patients who exhibit a greater that 3-fold transient rise in HIV-1 RNA levels 2 and 4 weeks postimmunization will be evaluated by Fisher's Exact and McNemar's Tests. ..
  24. Neonatal Immunization with Acellular Pertussis Vaccines
    Natasha Halasa; Fiscal Year: 2007
    ....
  25. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..2. Investigate whether Vspl enters BMEC. 3. Determine whether Vspl crosses BMEC barriers. 4. Identify the structural features that mediate the interaction of Vspl with BMEC. [unreadable] [unreadable]..
  26. Genetic Variability and Virulence of Human Adenovirus 7
    Adriana Kajon; Fiscal Year: 2005
    ..abstract_text> ..
  27. Epidemiologic Methods: Resistant Nosocomial Infections
    Marc Lipsitch; Fiscal Year: 2004
    ..This will in turn lead to better practices to reduce the incidence of ARNI. ..
  28. PROBIOTICS IN PEDIATRIC DIARRHEA IN PERU: PLANNING GRANT
    Richard Oberhelman; Fiscal Year: 2006
    ..Support for these activities during a planning period before the clinical trial will greatly facilitate the implementation of the trial. ..
  29. Cryptococcus gatti mating 1oci; mapping and gene study
    Vishnu Chaturvedi; Fiscal Year: 2004
    ..abstract_text> ..
  30. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  31. Serum Antibodies to Recombinant Pneumocystis Antigens
    Peter Walzer; Fiscal Year: 2009
    ..Data obtained from these studies will lead to the first standard antigen for PC serologic studies, and enhance our understanding of the epidemiology and immunology of PC infection. ..
  32. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  33. Study of risk factors of tick-borne encephalitis in Poland
    Pawel Stefanoff; Fiscal Year: 2009
    ....
  34. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2009
    ..Information gained from these studies will provide direct assessment of the molecular mechanisms used by the CGRP efferent feedback pathway to enhance sound-evoked activity in the cochlear nerve. ..
  35. Community Health Effects of Industrial Hog Operations
    Steven Wing; Fiscal Year: 2005
    ....
  36. Phase I Trial of Herceptin Plus IL12
    William Carson; Fiscal Year: 2003
    ..These studies will provide information on the actions of Herceptin and IL-12, enhance our ability to monitor the effects of antibody-based therapies, and permit the identification of specific markers of responsiveness. ..
  37. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  38. Correlative Studies for Phase II Trial of IL12 and IFNa
    William Carson; Fiscal Year: 2002
    ..This series of experiments will permit us to evaluate the patient response to cytokine therapy at the cellular and molecular levels and identify key determinants of cytokine responsiveness. ..
  39. Phase 2 Study of Anti Vegf Antibody in Melanoma
    William Carson; Fiscal Year: 2002
    ..Information gained from this trial will help us to understand the mechanism of action of anti-angiogenic drugs and help us to plan future studies in melanoma and other solid tumors. ..
  40. ROLE OF ADHERENCE IN KERATITIS
    Michael Gilmore; Fiscal Year: 2001
    ..abstract_text> ..
  41. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..abstract_text> ..
  42. Efficacy and Safety of AAV Gene Transfer for Hemophilia
    VALDER ARRUDA; Fiscal Year: 2004
    ..abstract_text> ..
  43. COMMUNITY HEALTH & ENVIRONMENTAL REAWAKENING
    Steven Wing; Fiscal Year: 2007
    ....
  44. NOVEL APICOMPLEXAN METABOLISM AND ORGANELLE TRANSIT
    Rima McLeod; Fiscal Year: 2005
    ..gondii, its gene regulation, organelle targeting and better characterization of possible novel antimicrobial agent targets in the shikimate pathway and its branches. ..
  45. PATHOGENESIS OF SEVERE DENGUE INFECTIONS IN VENEZUELA
    Alan Rothman; Fiscal Year: 2004
    ..The results may also identify key pathophysiologic mechanisms that can be targeted for novel approaches to the treatment of adults with denaue infections. ..
  46. Genotypes of Helicobacter Pylori in West Africa
    Richard Adegbola; Fiscal Year: 2005
    ..pylori colonization in West Africa differ from those seen in industrialized nations, and enable the development of appropriate treatment strategies for communities such as The Gambia. ..
  47. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
    ..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
  48. MATERNAL IMMUNIZATION TO PREVENT INFANT OTITIS MEDIA
    Patricia Ferrieri; Fiscal Year: 2005
    ..Results of this trial will have a profound impact on the broad field of maternal immunization to prevent early infant disease caused by a variety of infant bacterial and viral pathogens. ..
  49. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  50. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  51. Immune Responses in Genital Chlamydia Prior to Therapy
    WILLIAM GEISLER; Fiscal Year: 2005
    ..abstract_text> ..
  52. Rural Trial of Clinic Order Entry with Decision Support
    Matthew Samore; Fiscal Year: 2006
    ..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. [unreadable] [unreadable]..
  53. New Methods for Evaluating Interobserver Agreement
    Michael Haber; Fiscal Year: 2006
    ..Existing and new agreement indices will be compared and linked. All the proposed methods will be applied to real data sets from the behavioral and biomedical sciences. [unreadable] [unreadable]..
  54. ROLE OF RHOMBOID HOMOLOGUES IN MYCOBACTERIA SIGNALING
    Moses Joloba; Fiscal Year: 2006
    ..This will expand our understanding of mycobacterial biology and may provide novel candidate vaccines and drug targets. ..
  55. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  56. Vector-driven selection in dengue virus
    KATHRYN HANLEY; Fiscal Year: 2006
    ..Each mutant virus will be tested for its ability to infect mosquito and mammalian model systems. ..
  57. Enterococcus cytolysin: Regulation and structure
    Michael Gilmore; Fiscal Year: 2007
    ..abstract_text> ..
  58. GBS: Epidemiologic Characterization for Gene Discovery
    Betsy Foxman; Fiscal Year: 2007
    ..A better understanding of the molecular epidemiology and the identification of new GBS virulence genes will facilitate the discover of new therapies and prevention strategies for GBS disease. ..
  59. CELL TO CELL SIGNALING IN MYCOBACTERIA
    MOSES LUTAAKOME JOLOBA; Fiscal Year: 2010
    ..This will enrich our knowledge on mycobacterial biology and may reveal novel drug and vaccine targets. ..