lymphocyte activation

Summary

Summary: Morphologic alteration of small lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific antigens. It may also occur in vivo, as in GRAFT REJECTION and chronic myelogenous leukemia (LEUKEMIA, MYELOID, CHRONIC).

Top Publications

  1. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
  2. ncbi Immunobiology of dendritic cells
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Annu Rev Immunol 18:767-811. 2000
  3. doi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
  4. pmc Up on the tightrope: natural killer cell activation and inhibition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 9:495-502. 2008
  5. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
  6. pmc HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    Michael R Betts
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4781-9. 2006
  7. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  8. pmc T cell activation
    Jennifer E Smith-Garvin
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Immunol 27:591-619. 2009
  9. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
  10. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002

Research Grants

Detail Information

Publications314 found, 100 shown here

  1. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
    ....
  2. ncbi Immunobiology of dendritic cells
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Annu Rev Immunol 18:767-811. 2000
    ..Although our understanding of DC biology is still in its infancy, we are now beginning to use DC-based immunotherapy protocols to elicit immunity against cancer and infectious diseases...
  3. doi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
    ..Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells...
  4. pmc Up on the tightrope: natural killer cell activation and inhibition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 9:495-502. 2008
    ....
  5. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
    ..This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer...
  6. pmc HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    Michael R Betts
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4781-9. 2006
    ..Thus, rather than quantity or phenotype, the quality of the CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy...
  7. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  8. pmc T cell activation
    Jennifer E Smith-Garvin
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Immunol 27:591-619. 2009
    ..complex (MHC) complex pSMAC: peripheral supramolecular activation cluster PTK: protein tyrosine kinase Signal transduction: biochemical events linking surface receptor engagement to cellular responses TCR: T cell antigen receptor..
  9. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  10. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
    ..The unique features of this dual-engagement pathway should facilitate the development of therapies that specifically target autoreactive B cells...
  11. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    ....
  12. ncbi Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    P Waterhouse
    Department of Immunology, University of Toronto, Ontario, Canada
    Science 270:985-8. 1995
    ..Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis...
  13. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  14. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  15. pmc Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
    J Infect Dis 197:126-33. 2008
    ....
  16. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
    ..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs...
  17. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
    ..Importantly, rejection of highly immunogenic syngeneic tumors was impaired in Batf3-/- mice. These results suggest an important role for CD8alpha+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection...
  18. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  19. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  20. pmc Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    Robert J Johnston
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 325:1006-10. 2009
    ..These findings demonstrate that T(FH) cells are required for proper B cell responses in vivo and that Bcl6 and Blimp-1 play central but opposing roles in T(FH) differentiation...
  21. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  22. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  23. ncbi Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    E A Tivol
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 3:541-7. 1995
    ..In the absence of CTLA-4, peripheral T cells are activated, can spontaneously proliferate, and may mediate lethal tissue injury...
  24. ncbi The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    Arlene H Sharpe
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 8:239-45. 2007
    ..Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway...
  25. pmc The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 35:871-82. 2011
    ..Therefore, a Myc-dependent global metabolic transcriptome drives metabolic reprogramming in activated, primary T lymphocytes. This may represent a general mechanism for metabolic reprogramming under patho-physiological conditions...
  26. ncbi Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    Steven G Deeks
    San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    Blood 104:942-7. 2004
    ..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time...
  27. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections...
  28. ncbi Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Immunol Rev 212:8-27. 2006
    ....
  29. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  30. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
    ..These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells...
  31. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  32. ncbi T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Infect Dis 187:1534-43. 2003
    ..Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy...
  33. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ....
  34. pmc A protective function for interleukin 17A in T cell-mediated intestinal inflammation
    William O'Connor
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 10:603-9. 2009
    ..Our data demonstrate a protective function for IL-17 and identify T cells as not only the source but also a target of IL-17 in vivo...
  35. ncbi PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Nature 404:402-7. 2000
    ..These results indicate that PKC-theta functions in a unique pathway that links the TCR signalling complex to the activation of NF-kappaB in mature T lymphocytes...
  36. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  37. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  38. ncbi TNF/TNFR family members in costimulation of T cell responses
    Tania H Watts
    Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Annu Rev Immunol 23:23-68. 2005
    ..Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity...
  39. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004
    ..Their absence led to a failure of gestation due to immunological rejection of the fetus...
  40. ncbi CD107a as a functional marker for the identification of natural killer cell activity
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Massachusetts, USA
    J Immunol Methods 294:15-22. 2004
    ..Cumulatively, the data presented here demonstrate that CD107a is a sensitive marker of NK cell activity...
  41. ncbi MAP kinases in the immune response
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
    Annu Rev Immunol 20:55-72. 2002
    ..In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses...
  42. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
    ..XBP-1 is the only transcription factor known to be selectively and specifically required for the terminal differentiation of B lymphocytes to plasma cells...
  43. ncbi Natural killer cells in antiviral defense: function and regulation by innate cytokines
    C A Biron
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Immunol 17:189-220. 1999
    ....
  44. ncbi Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Nature 369:31-7. 1994
    ..The mice fail to clear lymphocytic choriomeningitis virus and they eliminate fibrosarcoma tumour cells with reduced efficiency. Perforin is therefore a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis...
  45. pmc Heterogeneity and plasticity of T helper cells
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Res 20:4-12. 2010
    ..In this review, we summarize recent reports on heterogeneity and plasticity of Th cells, and discuss potential mechanisms and implications of such features that Th cells display...
  46. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..in T-cell development before exit from the thymus, whereas S1P1 is downregulated during peripheral lymphocyte activation, and this is associated with retention in lymphoid organs...
  47. ncbi Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    M Muramatsu
    Department of Medical Chemistry, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan
    Cell 102:553-63. 2000
    ..These results suggest that AID may be involved in regulation or catalysis of the DNA modification step of both class switching and somatic hypermutation...
  48. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
    ..Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection...
  49. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation...
  50. ncbi Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    Mette D Hazenberg
    Department of Clinical Viro Immunology, Sanquin Research at CLB, Tropical Medicine and AIDS, Amsterdam, The Netherlands
    AIDS 17:1881-8. 2003
    ..HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood...
  51. ncbi CD28/B7 system of T cell costimulation
    D J Lenschow
    Committee on Immunology, Ben May Institute, Chicago, Illinois 60637, USA
    Annu Rev Immunol 14:233-58. 1996
    ..It is our hope and expectation that this review will provoke additional research that will unravel this important, yet complex, signaling pathway...
  52. ncbi Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  53. pmc Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    Ye Zheng
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Nature 458:351-6. 2009
    ..Our results indicate that T(reg) cells use components of the transcriptional machinery, promoting a particular type of effector CD4(+) T cell differentiation, to efficiently restrain the corresponding type of the immune response...
  54. pmc T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    Rajat Varma
    Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 25:117-27. 2006
    ..Our studies reveal a role for F-actin in TCR signaling beyond microcluster formation...
  55. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..Our findings support a model in which B cells compete for cytokines produced by follicular helper T cells that shape the affinity and isotype of the antibody response...
  56. ncbi Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    E Y Woo
    Department of Surgery, Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:4766-72. 2001
    ..Despite a generalized expression of lymphocyte activation markers in the tumor-associated T-cell populations, the CD8(+) T cells expressed low levels of CD25...
  57. pmc IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    Dimitra Zotos
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    J Exp Med 207:365-78. 2010
    ..The absence of IL-21 or IL-21 receptor does not abrogate the appearance of T cells in GCs or the appearance of CD4 T cells with a follicular helper phenotype. IL-21 thus controls fate choices of GC B cells directly...
  58. doi Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    Olivier Joffre
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    Immunol Rev 227:234-47. 2009
    ..Here, we review the differences between PRR-triggered and cytokine-induced DC activation and speculate on a potential role for DCs activated by inflammatory signals in tolerance induction rather than immunity...
  59. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  60. pmc Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    Kaori Sakuishi
    Center for Neurological Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 207:2187-94. 2010
    ..We further find that combined targeting of the Tim-3 and PD-1 pathways is more effective in controlling tumor growth than targeting either pathway alone...
  61. doi Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection
    Nadia Caccamo
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, University of Palermo, Palermo, Italy
    Eur J Immunol 40:2211-20. 2010
    ..Our results suggest that phenotypic and functional signatures of CD4(+) T cells may serve as immunological correlates of protection and curative host responses, and be a useful tool to monitor the efficacy of anti-mycobacterial therapy...
  62. pmc Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
    Moraima Guadalupe
    Department of Medical Microbiology and Immunology, University of California, Davis, California 95616, USA
    J Virol 77:11708-17. 2003
    ..Monitoring of the restoration and/or maintenance of CD4(+) T cells in GALT provides a more accurate assessment of the efficacy of antiviral host immune responses as well as HAART...
  63. pmc Reciprocal activating interaction between natural killer cells and dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
    J Exp Med 195:327-33. 2002
    ..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
  64. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  65. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ....
  66. pmc Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    M Paula Longhi
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1589-602. 2009
    ..Therefore, the adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity...
  67. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
    ....
  68. pmc MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
    Maurizio Ceppi
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 106:2735-40. 2009
    ..Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli...
  69. ncbi Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    Stephanie K Bunt
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    Cancer Res 67:10019-26. 2007
    ....
  70. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
    ..We hypothesize that IDO+ pDCs create a profoundly suppressive microenvironment within tumor-draining LNs via constitutive activation of Tregs...
  71. ncbi Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    Veronika Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nature 419:734-8. 2002
    ..This mode of T-cell silencing may promote tumour immune evasion and, by inference, compromise host resistance to infections...
  72. ncbi CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  73. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime...
  74. doi Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, RIKEN, Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Science 323:1488-92. 2009
    ..Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells...
  75. doi Cancer immunotherapy by dendritic cells
    Cornelis J M Melief
    Department of Immunohematology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands ISA Pharmaceuticals, 3723 MB Bilthoven, The Netherlands
    Immunity 29:372-83. 2008
    ..Here, I discuss the considerations for generating promising therapeutic antitumor vaccines that use DCs...
  76. ncbi The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells
    Guido Ferlazzo
    Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 33:306-13. 2003
    ..Activated NK cells, by limiting the supply of immature DC, may then exert a control on subsequent innate and adaptive immune responses...
  77. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  78. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals...
  79. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
  80. pmc The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
    Cameron S Brandt
    Molecular and Cell Based Discovery, ZymoGenetics Inc, Seattle, WA 98102, USA
    J Exp Med 206:1495-503. 2009
    ....
  81. pmc Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 192:1213-22. 2000
    ..These data show that immature and mature DCs induce different types of T cell responses: inflammatory Th1 cells are induced by mature DCs, and IL-10-producing T cell regulatory 1-like cells by immature DCs...
  82. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    ....
  83. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  84. ncbi The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology
    David M Sansom
    MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK
    Immunol Rev 212:131-48. 2006
    ..Here we review the main features of the CD28 and CTLA-4 system and examine how these impact upon Treg biology...
  85. pmc HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75725 Paris, France
    Proc Natl Acad Sci U S A 104:6776-81. 2007
    ..This constitutive antiviral capacity of CD8(+) T cells could account for the control of viral replication in HIC...
  86. pmc The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 10:314-24. 2009
    ..These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues...
  87. doi The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation
    Guifang Cai
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 229:244-58. 2009
    ..Therapies targeting the CRD1 of HVEM to block BTLA and CD160 binding are being developed to enhance immune responses and vaccination...
  88. pmc Cytokine-induced memory-like natural killer cells
    Megan A Cooper
    Rheumatology Division, Department of Medicine, and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1915-9. 2009
    ..Thus, these experiments identify an ability of innate immune cells to retain an intrinsic memory of prior activation, a function until now attributed only to antigen-specific adaptive immune cells...
  89. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
    ..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells...
  90. ncbi Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1230-7. 2003
    ..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
  91. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  92. pmc Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    Alexander Marson
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 445:931-5. 2007
    ..Foxp3 suppression of its targets appears to be crucial for the normal function of T(reg) cells, because overactive variants of some target genes are known to be associated with autoimmune disease...
  93. pmc T helper 17 cells promote cytotoxic T cell activation in tumor immunity
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 31:787-98. 2009
    ..Thus, Th17 cells elicited a protective inflammation that promotes the activation of tumor-specific CD8(+) T cells. These findings have important implications in antitumor immunotherapies...
  94. pmc Emerging concepts in the immunopathogenesis of AIDS
    Daniel C Douek
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Med 60:471-84. 2009
    ....
  95. pmc Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo
    Marina Babic
    Department of Histology and Embryology, Medical Faculty, University of Rijeka, 51000 Rijeka, Croatia
    J Exp Med 207:2663-73. 2010
    ....
  96. ncbi Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    F Cocchi
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Science 270:1811-5. 1995
    ..These data may have relevance for the prevention and therapy of AIDS...
  97. pmc Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    Minu K Srivastava
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Cancer Res 70:68-77. 2010
    ..In summary, MDSCs consume cystine and do not return cysteine to their microenvironment, thereby depriving T cells of the cysteine they require for activation and function...
  98. ncbi Human mesenchymal stem cells modulate allogeneic immune cell responses
    Sudeepta Aggarwal
    Osiris Therapeutics, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Blood 105:1815-22. 2005
    ....
  99. ncbi Hydrogen peroxide as second messenger in lymphocyte activation
    Michael Reth
    Max Planck Institute für Immunobiologie, Universitat Freiburg, Biologie III, Abteilung Molekulare Immunologie, Stuebeweg 51, Freiburg 79108, Germany
    Nat Immunol 3:1129-34. 2002
    Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear...
  100. ncbi Immune activation and inflammation in HIV-1 infection: causes and consequences
    V Appay
    Cellular Immunology Laboratory, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Pathol 214:231-41. 2008
    ..A simplified model of HIV pathogenesis is proposed, which links together the three major facets of HIV-1 infection: the massive depletion of CD4(+) T cells, the paradoxical immune activation and the exhaustion of regenerative capacity...
  101. pmc Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection
    Seung Hwan Lee
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Exp Med 206:2235-51. 2009
    ..Thus, the studies demonstrate a previously unappreciated critical role for activating receptors in keeping NK cells present during viral infection to regulate adaptive immune responses...

Research Grants72

  1. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2009
    ..To understand shared roles and mechanisms of lymphocyte activation following bacterial infection and toxicant exposure, we will study epithelial cell lymphocyte interactions ..
  2. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan Schneck; Fiscal Year: 2009
    ..These investigators bring innovative technology and incisive ideas to bear on the problem of lymphocyte activation and its regulation...
  3. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2010
    ..These investigators bring innovative technology and incisive ideas to bear on the problem of lymphocyte activation and its regulation...
  4. PTPN22 and Autoimmunity
    Nunzio Bottini; Fiscal Year: 2009
    ..tyrosine phosphatase LYP, which is expressed only in white blood cells and acts as a gatekeeper for T lymphocyte activation. We reported what was to us the remarkable and seminal observation that a missense single-nucleotide ..
  5. EPIDEMIOLOGY OF IMMUNOLOGIC LUNG DISEASE
    Kathleen Kreiss; Fiscal Year: 1990
    ..This proposal is the critical step in development of a screening test for the prevention of beryllium disease among the 800,000 Americans who have had industrial exposure to beryllium...
  6. Dissecting the Role of IL-12 in Naive CD8+ T cell Activation by Dendritic Cells
    CURTIS HENRY; Fiscal Year: 2007
    ..A complete understanding of how IL-12, and its antagonist interleukin 10, dictates cytotoxic lymphocyte activation (CTLs) remains to be determined...
  7. BIOLOGY OF THE CELL ADHESION MOLECULE CD31
    James Zehnder; Fiscal Year: 1992
    ..2. After T lymphocyte activation, CD31 expression is down-regulated. 3...
  8. PTPN22 and Autoimmunity
    Nunzio Bottini; Fiscal Year: 2010
    ..tyrosine phosphatase LYP, which is expressed only in white blood cells and acts as a gatekeeper for T lymphocyte activation. We reported what was to us the remarkable and seminal observation that a missense single-nucleotide ..
  9. PTPN22 and Autoimmunity
    Nunzio Bottini; Fiscal Year: 2010
    ..tyrosine phosphatase LYP, which is expressed only in white blood cells and acts as a gatekeeper for T lymphocyte activation. We reported what was to us the remarkable and seminal observation that a missense single-nucleotide ..
  10. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 1993
    ..that a methylated PAH (7,12-dimethylbenz(a)anthracene, DMBA) interferes with early events associated with lymphocyte activation in murine B and T cells exposed in vivo and in vitro...
  11. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 1992
    ..that a methylated PAH (7,12-dimethylbenz(a)anthracene, DMBA) interferes with early events associated with lymphocyte activation in murine B and T cells exposed in vivo and in vitro...
  12. MODULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1993
    ..not resting lymphocytes led to the discovery by our laboratory that calcitriol was a potent inhibitor of T lymphocyte activation and lymphokine production...
  13. TNF GENE EXPRESSION IN ACTIVATED LYMPHOCYTES
    Anne Goldfeld; Fiscal Year: 1993
    ..Moreover, these studies have the potential of elucidating early lymphocyte activation events common to both T- and B-cells and the transcription factors that are involved in initial lymphocyte ..
  14. MODULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1991
    ..not resting lymphocytes led to the discovery by our laboratory that calcitriol was a potent inhibitor of T lymphocyte activation and lymphokine production...
  15. MicroRNA regulation of human T and B cell activation
    Daniel Salomon; Fiscal Year: 2009
    ..of human immunity by targeting key differentially and constitutively expressed genes regulating T and B lymphocyte activation, differentiation and survival...
  16. MicroRNA regulation of human T and B cell activation
    Daniel R Salomon; Fiscal Year: 2010
    ..of human immunity by targeting key differentially and constitutively expressed genes regulating T and B lymphocyte activation, differentiation and survival...
  17. COCAINE AND CATECHOLAMINE EFFECTS ON T LYMPHOCYTES
    Thomas Klein; Fiscal Year: 1993
    ..the studies proposed, we will examine in detail several signal transduction molecular pathways involved in lymphocyte activation in order to obtain a clearer understanding of the molecular mechanisms involved in these cocaine effects...
  18. ROLE OF FC RECEPTOR IN THE AFFERENT LIMB OF THE AUTOIMMUNE RESPONSE
    Jeffrey Ravetch; Fiscal Year: 1999
    ..In the afferent limb, B cell FcRs (FcgammaRII) modulate lymphocyte activation by inhibiting proliferation and antibody production in response to co- ligation of BCR and FcRII...
  19. IMMUNOGENETICS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
    Bo Dupont; Fiscal Year: 1992
    ..of regulation of HLA gene expression and function of the HLA antigens particularly as they relate to T-lymphocyte activation and generation of helper T cells and cytotoxic T-cells...
  20. COCAINE AND CATECHOLAMINE EFFECTS ON T LYMPHOCYTES
    Thomas Klein; Fiscal Year: 1992
    ..the studies proposed, we will examine in detail several signal transduction molecular pathways involved in lymphocyte activation in order to obtain a clearer understanding of the molecular mechanisms involved in these cocaine effects...
  21. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2004
    ..of biological processes including the acute phase response, cell growth and apoptosis, inflammation and lymphocyte activation. TNF has two receptors: TNFR1and TNFR2...
  22. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2005
    ..of biological processes including the acute phase response, cell growth and apoptosis, inflammation and lymphocyte activation. TNF has two receptors: TNFR1and TNFR2...
  23. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2003
    ..of biological processes including the acute phase response, cell growth and apoptosis, inflammation and lymphocyte activation. TNF has two receptors: TNFR1and TNFR2...
  24. T CELL MEMORY GENERATION AND FUNCTION
    Susan Swain; Fiscal Year: 2002
    ..advances include, new understandings of the mechanisms of lymphocyte recognition, antigen presentation, lymphocyte activation and programmed cell death...
  25. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2006
    ..of biological processes including the acute phase response, cell growth and apoptosis, inflammation and lymphocyte activation. TNF has two receptors: TNFR1and TNFR2...
  26. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2005
    ..of biological processes including the acute phase response, cell growth and apoptosis, inflammation and lymphocyte activation. TNF has two receptors: TNFR1and TNFR2...
  27. T CELL MEMORY GENERATION AND FUNCTION
    Susan Swain; Fiscal Year: 2001
    ..advances include, new understandings of the mechanisms of lymphocyte recognition, antigen presentation, lymphocyte activation and programmed cell death...
  28. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2007
    ..of biological processes including the acute phase response, cell growth and apoptosis, inflammation and lymphocyte activation. TNF has two receptors: TNFR1and TNFR2...
  29. T CELL MEMORY GENERATION AND FUNCTION
    Susan Swain; Fiscal Year: 2000
    ..advances include, new understandings of the mechanisms of lymphocyte recognition, antigen presentation, lymphocyte activation and programmed cell death...
  30. TYROSINE PROTEIN KINASES AND LYMPHOCYTE ACTIVATION
    ROBERT GEAHLEN; Fiscal Year: 1992
    ..The methodologies that we propose to use include: 1) cellular assays of lymphocyte activation using cultured lymphocyte subpopulations and transformed lymphoid cell lines, 2) immunoprecipitations and ..
  31. TYROSINE PROTEIN KINASES AND LYMPHOCYTE ACTIVATION
    ROBERT GEAHLEN; Fiscal Year: 1993
    ..The methodologies that we propose to use include: 1) cellular assays of lymphocyte activation using cultured lymphocyte subpopulations and transformed lymphoid cell lines, 2) immunoprecipitations and ..
  32. T CELL MEMORY GENERATION AND FUNCTION
    Susan Swain; Fiscal Year: 1999
    ..advances include, new understandings of the mechanisms of lymphocyte recognition, antigen presentation, lymphocyte activation and programmed cell death...
  33. The Role of Dendritic Cells in Renal Immune Responses
    Karl Nath; Fiscal Year: 2007
    ..The mechanisms underlying T-lymphocyte activation in kidney disease are poorly understood, as are the mechanisms that prevent immune activation in the ..
  34. B Cell Lymphoma Therapy
    Yong Choi; Fiscal Year: 2007
    ..Our inducible lymphoma model in vivo offers unprecedented opportunities to evaluate the efficacy of the combined therapy and the genetic analysis of malignant transformation of lymphoma cells. ..
  35. The Role of Dendritic Cells in Renal Immune Responses
    Matthew Griffin; Fiscal Year: 2005
    ..The mechanisms underlying T-lymphocyte activation in kidney disease are poorly understood, as are the mechanisms that prevent immune activation in the ..
  36. B Cell Lymphoma Therapy
    Yong Choi; Fiscal Year: 2009
    ..Our inducible lymphoma model in vivo offers unprecedented opportunities to evaluate the efficacy of the combined therapy and the genetic analysis of malignant transformation of lymphoma cells. ..
  37. B Cell Lymphoma Therapy
    Yong Sung Choi; Fiscal Year: 2010
    ..Our inducible lymphoma model in vivo offers unprecedented opportunities to evaluate the efficacy of the combined therapy and the genetic analysis of malignant transformation of lymphoma cells. ..
  38. The Role of Dendritic Cells in Renal Immune Responses
    Matthew Griffin; Fiscal Year: 2004
    ..The mechanisms underlying T-lymphocyte activation in kidney disease are poorly understood, as are the mechanisms that prevent immune activation in the ..
  39. The Role of Dendritic Cells in Renal Immune Responses
    Matthew Griffin; Fiscal Year: 2006
    ..The mechanisms underlying T-lymphocyte activation in kidney disease are poorly understood, as are the mechanisms that prevent immune activation in the ..
  40. HUMAN LYMPHOCYTE ACTIVATION--ROLE OF DENDRITIC CELLS
    Ralph Steinman; Fiscal Year: 2002
    ..h) Use dendritic cells to generate antigen-specific cytolytic T lymphocytes (CTLs) to viral, tumor, and auto antigens. ..
  41. HUMAN LYMPHOCYTE ACTIVATION--ROLE OF DENDRITIC CELLS
    Ralph Steinman; Fiscal Year: 1999
    ..h) Use dendritic cells to generate antigen-specific cytolytic T lymphocytes (CTLs) to viral, tumor, and auto antigens. ..
  42. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2007
    Acute HIV infection is accompanied by a wave of lymphocyte activation and depletion that likely includes both infected and uninfected cells...
  43. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2007
    Acute HIV infection is accompanied by a wave of lymphocyte activation and depletion that likely includes both infected and uninfected cells...
  44. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2009
    Acute HIV infection is accompanied by a wave of lymphocyte activation and depletion that likely includes both infected and uninfected cells...
  45. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2007
    Acute HIV infection is accompanied by a wave of lymphocyte activation and depletion that likely includes both infected and uninfected cells...
  46. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    C Pauza; Fiscal Year: 2006
    Acute HIV infection is accompanied by a wave of lymphocyte activation and depletion that likely includes both infected and uninfected cells...
  47. MECHANISM OF LYMPHOCYTE ACTIVATION BY THIOL COMPOUNDS
    Michael Goodman; Fiscal Year: 1990
    ..Effects of B cell agonists and lymphokines on receptor expression will be examined throughout the cell cycle in responder, nonresponder and inducible cell types...
  48. Measles Virus Entry: Engagement of the Receptors and Infection Progression
    Roberto Cattaneo; Fiscal Year: 2007
    ..Measles virus (MV) interacts with two cellular receptors: the immune cell-specific protein signaling lymphocyte activation molecule (SLAM) and the ubiquitous regulator of complement activation membrane cofactor protein (MCP; CD46)..
  49. Measles Virus Entry: Engagement of the Receptors and Infection Progression
    Roberto B Cattaneo; Fiscal Year: 2010
    ..Measles virus (MV) interacts with two cellular receptors: the immune cell-specific protein signaling lymphocyte activation molecule (SLAM) and the ubiquitous regulator of complement activation membrane cofactor protein (MCP;CD46)...
  50. Measles Virus Entry: Engagement of the Receptors and Infection Progression
    Roberto Cattaneo; Fiscal Year: 2009
    ..Measles virus (MV) interacts with two cellular receptors: the immune cell-specific protein signaling lymphocyte activation molecule (SLAM) and the ubiquitous regulator of complement activation membrane cofactor protein (MCP;CD46)...
  51. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2000
    Lymphoid homeostasis is maintained by the dynamic regulation of lymphocyte activation, proliferation, programmed cell death, and tissue specific homing...
  52. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 1999
    Lymphoid homeostasis is maintained by the dynamic regulation of lymphocyte activation, proliferation, programmed cell death, and tissue specific homing...
  53. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2003
    Lymphoid homeostasis is maintained by the dynamic regulation of lymphocyte activation, proliferation, programmed cell death, and tissue specific homing...
  54. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2003
    Lymphoid homeostasis is maintained by the dynamic regulation of lymphocyte activation, proliferation, programmed cell death, and tissue specific homing...
  55. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2002
    Lymphoid homeostasis is maintained by the dynamic regulation of lymphocyte activation, proliferation, programmed cell death, and tissue specific homing...
  56. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2001
    Lymphoid homeostasis is maintained by the dynamic regulation of lymphocyte activation, proliferation, programmed cell death, and tissue specific homing...
  57. CYTOKINE BIOMARKERS OF ENVIRONMENTAL LUNG DISEASE
    Lee Newman; Fiscal Year: 1993
    ....
  58. DEREGULATION OF NFKB/REL BY TAX & ADULT T CELL LEUKEMIA
    Shao Cong Sun; Fiscal Year: 1999
    ..members of the NF- 1kappaBalpha/Rel family, which in turn induces various cellular genes involved in lymphocyte activation and growth...
  59. DEREGULATION OF NF-KB/REL BY TAX & ADULT T-CELL LEUKEMIA
    Shao Cong Sun; Fiscal Year: 1999
    ..members of the NF- 1kappaBalpha/Rel family, which in turn induces various cellular genes involved in lymphocyte activation and growth...
  60. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2006
    ..To understand shared roles and mechanisms of lymphocyte activation following bacterial infection and toxicant exposure, we will study epithelial cell lymphocyte interactions ..
  61. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 1992
    ..Understanding the roles of PKC and TPKs in T cell activation may lead to rational design of pharmacological approaches aimed at correcting abnormal T cell responses resulting from defective signaling...
  62. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 1993
    ..Understanding the roles of PKC and TPKs in T cell activation may lead to rational design of pharmacological approaches aimed at correcting abnormal T cell responses resulting from defective signaling...
  63. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2010
    ..To understand shared roles and mechanisms of lymphocyte activation following bacterial infection and toxicant exposure, we will study epithelial cell lymphocyte interactions ..
  64. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2007
    ..To understand shared roles and mechanisms of lymphocyte activation following bacterial infection and toxicant exposure, we will study epithelial cell lymphocyte interactions ..