immobilization

Summary

Summary: The restriction of the MOVEMENT of whole or part of the body by physical means (RESTRAINT, PHYSICAL) or chemically by ANALGESIA, or the use of TRANQUILIZING AGENTS or NEUROMUSCULAR NONDEPOLARIZING AGENTS. It includes experimental protocols used to evaluate the physiologic effects of immobility.

Top Publications

  1. pmc Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
    Arkan Abadi
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6518. 2009
  2. doi Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
    Agostino Gaudio
    Department of Internal Medicine, University of Catania, 95124 Catania, Italy
    J Clin Endocrinol Metab 95:2248-53. 2010
  3. pmc Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
    Elisa I Glover
    Department of Kinesiology Exercise Metabolism Research Group, McMaster University, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
    J Physiol 586:6049-61. 2008
  4. ncbi The role of NF-kappaB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Ann N Y Acad Sci 1057:431-47. 2005
  5. doi Comparison of Macintosh, Truview EVO2, Glidescope, and Airwayscope laryngoscope use in patients with cervical spine immobilization
    M A Malik
    Department of Anaesthesia, Clinical Sciences Institute, Galway University Hospitals, Galway, Ireland
    Br J Anaesth 101:723-30. 2008
  6. ncbi Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization
    Ian A F Stokes
    Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont 05405, USA
    Spine (Phila Pa 1976) 29:2724-32. 2004
  7. ncbi Immobilization stress induces BDNF in rat submandibular glands
    K Tsukinoki
    Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College, 82 Inaoka cho, Yokosuka, Kanagawa 238 8580, Japan
    J Dent Res 85:844-8. 2006
  8. doi Chronic immobilization stress alters aspects of emotionality and associative learning in the rat
    Gwendolyn E Wood
    The Laboratory of Neuroendocrinology The Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:282-92. 2008
  9. ncbi Effects of limb immobilization on brain plasticity
    N Langer
    Division of Neuropsychology, Institute of Psychology, and International Normal Aging and Plasticity Imaging Center, University of Zurich, Zurich, Switzerland
    Neurology 78:182-8. 2012
  10. ncbi Compression therapy promotes proliferative repair during rat Achilles tendon immobilization
    Nikos Schizas
    Orthopaedic Laboratory, Department of Molecular Medicine and Surgery, M1 02, The King Gustav V Research Building, Karolinska University Hospital 171 76 Stockholm, Sweden
    J Orthop Res 28:852-8. 2010

Detail Information

Publications281 found, 100 shown here

  1. pmc Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
    Arkan Abadi
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6518. 2009
    ..The purpose of this study was to examine changes in global gene transcription during immobilization-induced muscle atrophy in humans and then explore the effects of the most prominent transcriptional ..
  2. doi Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
    Agostino Gaudio
    Department of Internal Medicine, University of Catania, 95124 Catania, Italy
    J Clin Endocrinol Metab 95:2248-53. 2010
    ..Sclerostin, a Wnt signaling antagonist on the osteoblasts produced by osteocytes, is regulated by mechanical strain and is implicated in the pathogenesis of disuse bone loss. There are no data on sclerostin in humans...
  3. pmc Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
    Elisa I Glover
    Department of Kinesiology Exercise Metabolism Research Group, McMaster University, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
    J Physiol 586:6049-61. 2008
    ..We determined how 14 days of unilateral knee immobilization affected quadriceps myofibrillar protein synthesis (MPS) in young healthy subjects (10 men, 2 women, 21 +/- 1 ..
  4. ncbi The role of NF-kappaB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Ann N Y Acad Sci 1057:431-47. 2005
    ..The molecular mechanisms responsible for the muscle protein breakdown during immobilization in aging have been studied in our laboratory in a model of 24-month-old Wistar rats, immobilized for 4 weeks...
  5. doi Comparison of Macintosh, Truview EVO2, Glidescope, and Airwayscope laryngoscope use in patients with cervical spine immobilization
    M A Malik
    Department of Anaesthesia, Clinical Sciences Institute, Galway University Hospitals, Galway, Ireland
    Br J Anaesth 101:723-30. 2008
    ..of the Pentax AWS, Glidescope, and the Truview EVO2, in comparison with the Macintosh laryngoscope, when performing tracheal intubation in patients with neck immobilization using manual in-line axial cervical spine stabilization.
  6. ncbi Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization
    Ian A F Stokes
    Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont 05405, USA
    Spine (Phila Pa 1976) 29:2724-32. 2004
    A review of the literature on macromechanical factors that accelerate disc degeneration with particular focus on distinguishing the roles of immobilization and overloading.
  7. ncbi Immobilization stress induces BDNF in rat submandibular glands
    K Tsukinoki
    Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College, 82 Inaoka cho, Yokosuka, Kanagawa 238 8580, Japan
    J Dent Res 85:844-8. 2006
    ..b>Immobilization stress modifies BDNF mRNA expression in some organs...
  8. doi Chronic immobilization stress alters aspects of emotionality and associative learning in the rat
    Gwendolyn E Wood
    The Laboratory of Neuroendocrinology The Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:282-92. 2008
    ..Chronic immobilization stress (CIS) induces anxiety behavior and dendritic hypertrophy in the basolateral amygdala, which persist ..
  9. ncbi Effects of limb immobilization on brain plasticity
    N Langer
    Division of Neuropsychology, Institute of Psychology, and International Normal Aging and Plasticity Imaging Center, University of Zurich, Zurich, Switzerland
    Neurology 78:182-8. 2012
    ..Therefore, we conducted a longitudinal study to investigate whether limb immobilization after unilateral arm injury is reflected in structural plastic changes in gray matter (cortical thickness) and ..
  10. ncbi Compression therapy promotes proliferative repair during rat Achilles tendon immobilization
    Nikos Schizas
    Orthopaedic Laboratory, Department of Molecular Medicine and Surgery, M1 02, The King Gustav V Research Building, Karolinska University Hospital 171 76 Stockholm, Sweden
    J Orthop Res 28:852-8. 2010
    Achilles tendon ruptures are treated with an initial period of immobilization, which obstructs the healing process partly by a reduction of blood circulation...
  11. ncbi Effects of 3 days unloading on molecular regulators of muscle size in humans
    T Gustafsson
    Department of Laboratory Medicine, Section of Clinical Physiology, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden
    J Appl Physiol (1985) 109:721-7. 2010
    ..Further, the reported difference in gene expression pattern across muscles suggests that mechanisms regulating protein content in human skeletal muscle are influenced by phenotype and/or function...
  12. doi Cone-beam CT assessment of interfraction and intrafraction setup error of two head-and-neck cancer thermoplastic masks
    Michael Velec
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 76:949-55. 2010
    ..To prospectively compare setup error in standard thermoplastic masks and skin-sparing masks (SSMs) modified with low neck cutouts for head-and-neck intensity-modulated radiation therapy (IMRT) patients...
  13. ncbi Effects of aging on human skeletal muscle after immobilization and retraining
    C Suetta
    Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 NV Copenhagen, Denmark
    J Appl Physiol (1985) 107:1172-80. 2009
    ..on skeletal muscle in young individuals are well elucidated, only little is known about the consequence of immobilization and the regenerative capacity in elderly individuals...
  14. ncbi Submandibular glands contribute to increases in plasma BDNF levels
    K Tsukinoki
    Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    J Dent Res 86:260-4. 2007
    ..Expression of BDNF mRNA has been identified in the submandibular glands when male rats are exposed to acute immobilization stress...
  15. ncbi Repositioning accuracy of two different mask systems-3D revisited: comparison using true 3D/3D matching with cone-beam CT
    Judit Boda-Heggemann
    Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany
    Int J Radiat Oncol Biol Phys 66:1568-75. 2006
    ..We analyzed the accuracy of commercially available head mask systems, using true 3D/3D matching, with X-ray volume imaging and cone-beam CT...
  16. ncbi A practical method to achieve prostate gland immobilization and target verification for daily treatment
    A V D'Amico
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 51:1431-6. 2001
    A practical method to achieve prostate immobilization and daily target localization for external beam radiation treatment is described.
  17. ncbi Short-term immobilization and recovery affect skeletal muscle but not collagen tissue turnover in humans
    Britt Christensen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:1845-51. 2008
    Not much is known about the effects of immobilization and subsequent recovery on tendon connective tissue...
  18. ncbi Strength training the free limb attenuates strength loss during unilateral immobilization
    Jonathan P Farthing
    College of Kinesiology, Univ of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Appl Physiol (1985) 106:830-6. 2009
    The objective was to determine if strength training the free limb during a 3-wk period of unilateral immobilization attenuates strength loss in the immobilized limb through cross-education...
  19. doi Random positional variation among the skull, mandible, and cervical spine with treatment progression during head-and-neck radiotherapy
    Peter H Ahn
    Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA
    Int J Radiat Oncol Biol Phys 73:626-33. 2009
    With 54 degrees of freedom from the skull to mandible to C7, ensuring adequate immobilization for head-and-neck radiotherapy (RT) is complex. We quantify variations in skull, mandible, and cervical spine movement between RT sessions.
  20. doi Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 27:274-80. 2009
    Healing after mobilization versus immobilization was assessed in a model of rat Achilles tendon rupture, by RT-PCR at 8 and 17 days and by histological analyses at 14 and 28 days postrupture...
  21. doi Inter- and intrafraction patient positioning uncertainties for intracranial radiotherapy: a study of four frameless, thermoplastic mask-based immobilization strategies using daily cone-beam CT
    Erik Tryggestad
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 80:281-90. 2011
    To determine whether frameless thermoplastic mask-based immobilization is adequate for image-guided cranial radiosurgery.
  22. ncbi Failure of the interosseous membrane to heal with immobilization, pinning of the distal radioulnar joint, and bipolar radial head replacement in a case of Essex-Lopresti injury: case report
    Hyun Sik Gong
    Department of Orthopaedics, Hand and Upper Extremity Service, Seoul National University Bundang Hospital, Seongnam, Korea
    J Hand Surg Am 35:976-80. 2010
    ..This case demonstrates that failure of the interosseous membrane can occur even in a properly replaced bipolar radial head with adequate immobilization of the forearm and pinning of the distal radioulnar joint.
  23. doi Removing a patient from the spine board: is the lift and slide safer than the log roll?
    Marybeth Horodyski
    Department of Orthopaedic Surgery, University of Florida, Gainesville, Florida, USA
    J Trauma 70:1282-5; discussion 1285. 2011
    After spine board immobilization of the trauma victim and transport to the hospital, the patient is removed from the spine board as soon as practical...
  24. ncbi Enhancement of adenoviral gene transfer to adult rat cardiomyocytes in vivo by immobilization and ultrasound treatment of the heart
    M Sato
    Department of Cardiac Medicine, NHLI Division, Imperial College London, UK
    Gene Ther 12:936-41. 2005
    ..Brief immobilization of the ventricle during and after injection using a haemoclip increased the number of transfected rod-shaped, ..
  25. doi Effects of cross-education on the muscle after a period of unilateral limb immobilization using a shoulder sling and swathe
    Charlene R A Magnus
    College of Kinesiology, University of Saskatchewan, 87 Campus Dr, Saskatoon, SK S7N 5B2, Canada
    J Appl Physiol (1985) 109:1887-94. 2010
    The purpose of this study was to apply cross-education during 4 wk of unilateral limb immobilization using a shoulder sling and swathe to investigate the effects on muscle strength, muscle size, and muscle activation...
  26. ncbi Short-term immobilization after eccentric exercise. Part II: creatine kinase and myoglobin
    Stephen P Sayers
    Human Physiology Laboratory, Department of Health Sciences, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Avenue, Boston, MA 02215, USA
    Med Sci Sports Exerc 35:762-8. 2003
    ..We previously found short-term immobilization blunted the rise in plasma CK after eccentric exercise, suggesting subsequent movement of damaged muscle may ..
  27. ncbi Muscle atrophy in immobilization and senescence in humans
    Andrew J Murton
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, The University of Nottingham, Nottingham, UK
    Curr Opin Neurol 22:500-5. 2009
    ..the mechanisms thought to be responsible for the determination of muscle mass during health, ageing and immobilization in humans have presented findings that have wide ranging implications...
  28. doi Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining
    Lars Hvid
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 109:1628-34. 2010
    ..Thus the purpose of this study was to investigate the effects of 2 wk of immobilization followed by 4 wk of retraining on knee extensor muscle mechanical function (e.g...
  29. doi Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnover
    Michael J Rennie
    University of Nottingham, School of Graduate Entry Medicine and Health, City Hospital, Derby, DE22 3DT, UK
    Appl Physiol Nutr Metab 34:377-81. 2009
    ..Exercise may retune the amino acid and (or) insulin sensitivity of muscle in older people...
  30. ncbi Single and repeated immobilization stress differentially trigger induction and phosphorylation of several transcription factors and mitogen-activated protein kinases in the rat locus coeruleus
    Meleik A Hebert
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurochem 95:484-98. 2005
    ..Rats were exposed to single or repeated immobilization stress (IMO) for brief (5 min), intermediate (30 min) or sustained (2 h) duration...
  31. ncbi An inexpensive and simple method for thermally stable immobilization of DNA on an unmodified glass surface: UV linking of poly(T)10-poly(C)10-tagged DNA probes
    Haukur Gudnason
    DTU Nanotech, Department of Micro and Nanotechnology, Technical University of Denmark, Lyngby
    Biotechniques 45:261-71. 2008
    ..In conclusion, our results show that using TC-tagged DNA probes immobilized on an unmodified glass surface is a robust, heat-stable, very simple, and inexpensive method for manufacturing DNA microarrays...
  32. pmc Robotic-based carbon ion therapy and patient positioning in 6 degrees of freedom: setup accuracy of two standard immobilization devices used in carbon ion therapy and IMRT
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 7:51. 2012
    ..particle radiotherapy in 6 degrees of freedom (DOF) and intensity-modulated radiotherapy (IMRT, 3 DOF) for two immobilization devices (Scotchcast masks vs thermoplastic head masks) currently in use at our institution for fractionated ..
  33. ncbi Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1397-406. 2006
    ..We conclude that some aromatic anesthetics may produce immobility in the face of noxious stimulation by blocking the action of glutamate on NMDA receptors but that conventional inhaled anesthetics do not...
  34. ncbi Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin
    M Denda
    Life Science Research Laboratories, Shiseido Research Center 2, Yokohama, Japan
    Br J Dermatol 138:780-5. 1998
    To examine the effect of stress on skin homeostasis, cutaneous barrier recovery was measured in rate exposed to immobilization stress after tape stripping or sodium dodecyl sulphate treatment...
  35. doi Neural responses in rat brain during acute immobilization stress: a [F-18]FDG micro PET imaging study
    Kang Keyng Sung
    Department of Neuroscience and Oriental Medicine, Wonkwang University, Iksan, South Korea
    Neuroimage 44:1074-80. 2009
    ..Animals were given immobilization stress for 1 or 2 h, or 1-h stress followed by 1-h recovery, after which their brains were scanned...
  36. doi Exercise and immobilization in aging animals: the involvement of oxidative stress and NF-kappaB activation
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Free Radic Biol Med 44:202-14. 2008
    ..Its involvement in exercise and immobilization has been demonstrated in several studies, indicating that these conditions may lead to inflammatory responses ..
  37. ncbi Comparison of setup accuracy of three different thermoplastic masks for the treatment of brain and head and neck tumors
    L Gilbeau
    Radiation Oncology Department, , St-Luc University Hospital, 10 Ave. Hippocrate, B-1200 Brussels, Belgium
    Radiother Oncol 58:155-62. 2001
    ..The purpose of this study was to compare the setup accuracy of three different thermoplastic masks used for immobilization of patients with brain or head and neck tumors...
  38. doi Low-volume resistance exercise attenuates the decline in strength and muscle mass associated with immobilization
    Bryan R Oates
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Muscle Nerve 42:539-46. 2010
    ..of low-volume resistance exercise (EX) for the attenuation of loss of muscle mass and strength during leg immobilization. Men (N = 5) and women (N = 12, age 24 ± 5 years, body mass index 25.4 ± 3...
  39. doi Immediate-early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c-fos mRNA to adaptation
    Sheila Ons
    Department of Cellular Biology, Physiology and Immunology, Institute of Neuroscience and Animal Physiology Unit, School of Biosciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    Eur J Neurosci 31:2043-52. 2010
    ..and arc (activity-regulated cytoskeleton-associated protein) after repeated exposure to a severe stressor: immobilization on wooden boards (IMO)...
  40. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
  41. ncbi Acute treatment of inversion ankle sprains: immobilization versus functional treatment
    Morgan H Jones
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Orthop Relat Res 455:169-72. 2007
    ..We conducted a systematic review of the literature to evaluate the effect of immobilization versus early functional treatment on time to return to preinjury activity after inversion ankle sprain...
  42. doi Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex
    Yeon Joo
    Department of Anatomy and Neurobiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Neurosci Lett 461:121-5. 2009
    ..Mice were subjected to immobilization stress for 2h per day for 15 consecutive days and the behavior of the mice was examined...
  43. doi Tracheal intubation in patients with cervical spine immobilization: a comparison of the Airwayscope, LMA CTrach, and the Macintosh laryngoscopes
    M A Malik
    Department of Anaesthesia, Galway University Hospitals, Galway, Ireland
    Br J Anaesth 102:654-61. 2009
    ..the effectiveness of the Pentax AWS, and the LMA CTrach, in comparison with the Macintosh laryngoscope, when performing tracheal intubation in patients with neck immobilization using manual in-line axial cervical spine stabilization.
  44. doi The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans
    K Sakuma
    Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, Toyohashi, Japan
    Acta Physiol (Oxf) 197:151-9. 2009
    ....
  45. ncbi Out-of-hospital spinal immobilization: its effect on neurologic injury
    M Hauswald
    Department of Emergency Medicine, University of New Mexico, School of Medicine, Albuquerque 87131 5246, USA
    Acad Emerg Med 5:214-9. 1998
    To examine the effect of emergency immobilization on neurologic outcome of patients who have blunt traumatic spinal injuries.
  46. ncbi Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation
    Fei Zeng
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
    Lab Chip 8:653-6. 2008
    Techniques for stable, rapid and repeatable small-animal immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multi-cellular organisms...
  47. ncbi Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA
    Ye Liu
    Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602, Singapore
    Angew Chem Int Ed Engl 44:4782-5. 2005
  48. ncbi c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization
    M A Medeiros
    Departamento de Ciencias Fisiologicas, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Brasil
    Braz J Med Biol Res 36:1673-84. 2003
    ..Repeated immobilization protocols (6 days, 1 h/day and 13 days, 2 h/day) were used to reduce the effect of acute immobilization stress ..
  49. doi Interfractional set-up errors evaluation by daily electronic portal imaging of IMRT in head and neck cancer patients
    Berrin Pehlivan
    Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    Acta Oncol 48:440-5. 2009
    ..We aimed to evaluate whether a daily PI is worthwhile and we derived the Planning Target Volume (PTV) margins from the estimation of systematic and random errors...
  50. doi Incidence of and risk factors for complications associated with halo-vest immobilization: a prospective, descriptive cohort study of 239 patients
    Joost J van Middendorp
    Department of Orthopaedics, University Medical Center Nijmegen, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Bone Joint Surg Am 91:71-9. 2009
    Since high rates of serious complications, such as death and pneumonia, during halo-vest immobilization have been reported, there has been a tendency of restraint with regard to the use of the halo vest...
  51. ncbi Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 28:103-10. 1997
    ..Male Wistar rats (6 weeks old) were exposed to immobilization stress for 8 h and their brains were processed for in situ hybridization histochemistry...
  52. ncbi Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress
    Marco Cecchi
    The University of Michigan, Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuropharmacology 43:1139-47. 2002
    ..microinjected bilaterally into CeA of male Sprague-Dawley rats, and anxiety-like behavioral responses to acute immobilization stress were measured on the Social Interaction (SI) test and on the Elevated Plus-maze (EPMZ)...
  53. doi Tracheal intubation with videolaryngoscopes in patients with cervical spine immobilization: a randomized trial of the Airway Scope and the GlideScope
    E H C Liu
    Department of Anaesthesia, National University Health System, National University of Singapore, Singapore
    Br J Anaesth 103:446-51. 2009
    ..We tested this hypothesis in a randomized comparison of the two videolaryngoscopes in patients whose cervical spines were immobilized...
  54. ncbi Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element
    Takuro Yamamoto
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:42036-43. 2005
    ....
  55. ncbi Effects of lactoferrin on the immune response modified by the immobilization stress
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 57:811-7. 2005
    ..of orally administered lactoferrin (LF) on the cellular and humoral immune responses in mice subjected to immobilization stress (IS) were investigated...
  56. ncbi A new method of immobilization after traumatic anterior dislocation of the shoulder: a preliminary study
    Eiji Itoi
    Department of Orthopedic Surgery, Akita University School of Medicine, Hondo, Akita, Japan
    J Shoulder Elbow Surg 12:413-5. 2003
    This preliminary prospective study was conducted to determine whether immobilization with the arm in external rotation would decrease the rate of recurrence after initial traumatic anterior dislocation of the shoulder...
  57. ncbi Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging
    D Michael Lovelock
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 32:2606-14. 2005
    ..doses requires highly conformal dose distributions, accurate patient setup, setup verification, and patient immobilization. An immobilization cradle has been designed to facilitate the rapid setup and radiation treatment of patients ..
  58. doi The Fracture and Immobilization Score (FRISC) for risk assessment of osteoporotic fracture and immobilization in postmenopausal women--A joint analysis of the Nagano, Miyama, and Taiji Cohorts
    Shiro Tanaka
    Division of Clinical Trial Design and Management, Translational Research Center, Kyoto University, Kyoto, Japan
    Bone 47:1064-70. 2010
    We aimed to (i) explore risk factors for major osteoporotic fracture or immobilization; (ii) develop a prediction model that can be used to assess the risk of fracture and immobilization; and (iii) assess external validity of the final ..
  59. doi Motion within the unstable cervical spine during patient maneuvering: the neck pivot-shift phenomenon
    Ran Lador
    Spine Research Laboratory, Michael E DeBakey Veterans Administration Medical Center, Houston, Texas 77030, USA
    J Trauma 70:247-50; discussion 250-1. 2011
    ..Little is known about the biomechanics of cervical stabilization; hence, it is difficult to develop and test improved immobilization strategies.
  60. ncbi Different effects of novel stressors on sympathoadrenal system activation in rats exposed to long-term immobilization
    Sladjana Dronjak
    Institute of Vinca, Belgrade, Serbia and Montenegro, P O Box 522 090, 11001 Belgrade
    Ann N Y Acad Sci 1018:113-23. 2004
    ..levels of catecholamines (CA) and corticosterone (COR) of rats after a single (2-h) or long-term repeated immobilization (41 times, 2 h daily) and in rats adapted to long-term immobilization exposed once to the novel stress of cold ..
  61. ncbi A comparison of carfentanil/xylazine and Telazol/xylazine for immobilization of white-tailed deer
    Brad F Miller
    Department of Forestry, Wildlife and Fisheries, University of Tennessee, 274 Ellington Hall, Knoxville, Tennessee 37996, USA
    J Wildl Dis 39:851-8. 2003
    ..From this study, we selected a dose of carfentanil/xylazine for the purpose of comparing immobilization parameters and physiologic effects with those of a combination of tiletamine and zolazepam (Telazol) and ..
  62. doi Immobilization and splinting in mountain rescue. Official Recommendations of the International Commission for Mountain Emergency Medicine, ICAR MEDCOM, Intended for Mountain Rescue First Responders, Physicians, and Rescue Organizations
    John Ellerton
    Mountain Rescue Council, England and Wales, Penrith, Cumbria, England
    High Alt Med Biol 10:337-42. 2009
    b>Immobilization and splinting of fractures are essential to reduce morbidity and mortality in mountain rescue...
  63. doi Quercetin protects against acute immobilization stress-induced behaviors and biochemical alterations in mice
    Anil Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    J Med Food 11:469-73. 2008
    ..The present study was designed to investigate protective effects of quercetin, a bioflavonoid, against acute immobilization-induced behavioral and biochemical alterations in mice. Mice were immobilized for a period of 6 hours...
  64. ncbi Spine immobilization in penetrating trauma: more harm than good?
    Elliott R Haut
    Division of Acute Care Surgery, Department of Surgery, The Johns Hopkins Hospital, 600 North Wolfe Street, 625 Osler, Baltimore, MD 21287, USA
    J Trauma 68:115-20; discussion 120-1. 2010
    Previous studies have suggested that prehospital spine immobilization provides minimal benefit to penetrating trauma patients but takes valuable time, potentially delaying definitive trauma care...
  65. doi Setup reproducibility for thoracic and upper gastrointestinal radiation therapy: Influence of immobilization method and on-line cone-beam CT guidance
    Winnie Li
    Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Med Dosim 35:287-96. 2010
    ..report the setup reproducibility of thoracic and upper gastrointestinal (UGI) radiotherapy (RT) patients for 2 immobilization methods evaluated through cone-beam computed tomography (CBCT) image guidance, and present planning target ..
  66. ncbi Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization
    A M Liphardt
    Institute of Aerospace Medicine, Deutsches Zentrum fur Luft und Raumfahrt, DLR, Cologne, Germany
    Osteoarthritis Cartilage 17:1598-603. 2009
    To test the hypotheses that 1) 14-days of immobilization of young healthy subjects using a 6 degrees -"head-down-tilt-bed-rest"-model (6 degrees -HDT) would reduce cartilage thickness in the knee and serum Cartilage oligometric matrix ..
  67. ncbi Generation of live-cell microarrays by means of DNA-Directed immobilization of specific cell-surface ligands
    Hendrik Schroeder
    Biologisch Chemische Mikrostrukturtechnik, Fachbereich Chemie, Universitat Dortmund, Dortmund, Germany
    Angew Chem Int Ed Engl 46:4180-3. 2007
  68. ncbi Sequential changes in transforming growth factor (TGF)-beta1 concentration in synovial fluid and mRNA expression of TGF-beta1 receptors in chondrocytes after immobilization of rabbit knees
    R Okazaki
    Department of Radiation Biology and Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Bone Miner Metab 19:228-35. 2001
    ..in synovial fluid and the mRNA expression of TGF-beta1 receptor type I (RI) and II (RII) in chondrocytes after immobilization. The combination of TGF-beta1 and bFGF had a synergistic effect on the proliferation of chondrocytes obtained ..
  69. doi Setup uncertainties of anatomical sub-regions in head-and-neck cancer patients after offline CBCT guidance
    Simon van Kranen
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 73:1566-73. 2009
    ..To quantify local geometrical uncertainties in anatomical sub-regions during radiotherapy for head-and-neck cancer patients...
  70. pmc Deficiency of antinociception and excessive grooming induced by acute immobilization stress in Per1 mutant mice
    Jing Zhang
    Behavioral Genetics Centre, Institute of Psychology, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 6:e16212. 2011
    ..In the present study we observed the alterations in grooming and nociceptive behaviors induced by acute immobilization stress in Per1 mutant mice and other genotypes (wild types and Per2 mutant)...
  71. doi Central nervous adaptations following 1 wk of wrist and hand immobilization
    Jesper Lundbye-Jensen
    Department of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute 22 3, Blegdamsvej 3, Copenhagen 2200, Denmark
    J Appl Physiol (1985) 105:139-51. 2008
    ..but little is known about central nervous system plasticity accompanying reduced physical activity and immobilization. In the present study we investigated whether plastic neural changes occur in relation to 1 wk of ..
  72. pmc Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatment
    Esther L Sabban
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, N Y 10595, USA
    Neuroendocrinology 89:98-108. 2009
    ..Here, we examine the kinetics and persistence of cardiovascular and locomotor responses to single and repeated immobilization stress (IMO), with and without prior treatment with adrenocorticotropic hormone (ACTH)...
  73. ncbi The effect of a low dose of clenbuterol on rat soleus muscle submitted to joint immobilization
    K M Cancelliero
    Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP, Brasil
    Braz J Med Biol Res 41:1054-8. 2008
    The aim of the present study was to evaluate the effect of joint immobilization on morphometric parameters and glycogen content of soleus muscle treated with clenbuterol...
  74. doi Comparison of repositioning accuracy of two commercially available immobilization systems for treatment of head-and-neck tumors using simulation computed tomography imaging
    Ronny L Rotondo
    Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec, Canada
    Int J Radiat Oncol Biol Phys 70:1389-96. 2008
    To compare the setup accuracy, comfort level, and setup time of two immobilization systems used in head-and-neck radiotherapy.
  75. ncbi Assessment of a customised immobilisation system for head and neck IMRT using electronic portal imaging
    Mandy Humphreys
    Radiotherapy Department, Royal Marsden NHS Trust, London, UK
    Radiother Oncol 77:39-44. 2005
    ..To evaluate set-up reproducibility of a cabulite shell and determine CTV-PTV margins for head and neck intensity-modulated-radiotherapy...
  76. pmc Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization
    Jennifer E Stevens-Lapsley
    Dept of Physical Therapy, Univ of Florida, Gainesville, 32610, USA
    Am J Physiol Endocrinol Metab 299:E730-40. 2010
    ..on the recovery of muscle size and function during reloading/reambulation after a period of cast immobilization in predominantly fast twitch muscles...
  77. doi Improved immobilization using an individual head support in head and neck cancer patients
    Antonetta C Houweling
    Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
    Radiother Oncol 96:100-3. 2010
    The benefits of a patient-specific head support, developed to improve immobilization during radiotherapy, were determined in head and neck cancer patients. Cone-beam CTs were registered to the planning CT in five regions...
  78. ncbi [Comparison of two different laryngeal mask models for airway management in patients with immobilization of the cervical spine]
    C Gernoth
    Universitätsklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum, Mannheim del berg de
    Anaesthesist 55:263-9. 2006
    ..Supraglottic airway devices can be important alternatives for oxygenation under these circumstances. The Ambu laryngeal mask (ALM) and the LMA-Classic (LMA) are compared in patients with immobilization of the cervical spine.
  79. ncbi Intra- and interfractional patient motion for a variety of immobilization devices
    Martijn Engelsman
    Northeast Proton Therapy Center, Massachusetts General Hospital and Department of Radiation Oncology, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Med Phys 32:3468-74. 2005
    The magnitude of inter- and intrafractional patient motion has been assessed for a broad set of immobilization devices...
  80. doi A comparison of two immobilization systems for stereotactic body radiation therapy of lung tumors
    Kathy Han
    Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada M4N 3M5
    Radiother Oncol 95:103-8. 2010
    This study aims to compare the efficacy, efficiency and comfort level of two immobilization systems commonly used in lung stereotactic body radiation therapy (SBRT): the Bodyfix and the abdominal compression plate (ACP).
  81. ncbi Modification of Gill-Thomas-Cosman frame for extracranial head-and-neck stereotactic radiotherapy
    Alireza Kassaee
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Int J Radiat Oncol Biol Phys 57:1192-5. 2003
    ....
  82. ncbi Immobilization stress-induced thymocyte apoptosis in rats
    K Hatanaka
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Life Sci 69:155-65. 2001
    b>Immobilization of rats is a well known model of emotional stress. We studied apoptosis in rat thymocytes during immobilization for 2-8 hours (h)...
  83. ncbi Effect of electroacupuncture on response to immobilization stress
    Chae H Yang
    Department of Physiology, College of Oriental Medicine, Kyungsan University, Taegu, South Korea
    Pharmacol Biochem Behav 72:847-55. 2002
    Forced immobilization is a simple and effective stressor which produces large increases in heart rate (HR), blood pressure (BP), and plasma levels of norepinephrine (NE) and epinephrine (EPI)...
  84. ncbi Acute immobilization stress induces clinical and neuroimmunological alterations in experimental murine cutaneous leishmaniasis
    M R Ruiz
    Laboratorio de Biologia Molecular, Instituto de Biomedicina, Universidad Central de Venezuela, Apartado 4043, Caracas 1010 A, Venezuela
    Br J Dermatol 149:731-8. 2003
    ..In American cutaneous leishmaniasis, we have shown the importance of the epidermis as a regulatory site, with the key participation of Langerhans cells...
  85. ncbi The effect of acute immobilization stress on the abundance of corticotropin-releasing factor receptor in lymphoid organs
    M Radulovic
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    J Neuroimmunol 103:153-64. 2000
    ..We demonstrate here that immobilization, a predominantly psychological stress, exhibited a similar effect...
  86. ncbi Immediate mobilization gives good results in boxer's fractures with volar angulation up to 70 degrees: a prospective randomized trial comparing immediate mobilization with cast immobilization
    Markwin G Statius Muller
    Department of Surgery, Sint Lucas Andreas Hospital, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands
    Arch Orthop Trauma Surg 123:534-7. 2003
    ..Therefore, the aim of our study was to compare randomly and prospectively the results of an immobilization treatment for 3 weeks with cast with a functional treatment, all with accepted angulations up to 70 degrees.
  87. ncbi Treatment of complete rupture of the lateral ligaments of the ankle: a randomized clinical trial comparing cast immobilization with functional treatment
    Jordi Ardèvol
    Orthopedic Surgery Department, Hospital de Mataro, C de Cirera s n Mataró, 08304 Barcelona, Spain
    Knee Surg Sports Traumatol Arthrosc 10:371-7. 2002
    This study compared the therapeutic efficacy between cast immobilization and functional treatment of grade III ruptures of the lateral ankle ligaments...
  88. ncbi Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse
    S Takahashi
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan 359-1192
    Endocrinology 142:4910-7. 2001
    ..Forced swimming, immobilization, and lipopolysaccharide injection elevated mPer1 gene expression in the PVN but not in the SCN or liver...
  89. doi Immobilization impairs tactile perception and shrinks somatosensory cortical maps
    Silke Lissek
    Department of Neurology, BG Kliniken Bergmannsheil, Ruhr University, D 44780 Bochum, Germany
    Curr Biol 19:837-42. 2009
    ..Here, we report that a few weeks of hand and arm immobilization by cast wearing significantly reduced hand use and impaired tactile acuity, associated with reduced activation ..
  90. ncbi Changes in angiotensin AT1 receptor mRNA levels in the rat brain after immobilization stress and inhibition of central nitric oxide synthase
    A Kiss
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, 833 06 Bratislava, Slovakia
    Endocr Regul 35:65-70. 2001
    To study functional interactions between angiotensin II AT1 receptors and nitric oxide (NO) activity in different brain areas in rats exposed to immobilization stress.
  91. ncbi Effect of water activity and immobilization on fatty acid selectivity for esterification reactions mediated by lipases
    C H Lee
    Department of Food Science, University of Wisconsin, Babcock Hall, 1605 Linden Drive, Madison, WI 53706, USA
    Biotechnol Bioeng 75:219-27. 2001
    The effect of water activity (a(w)) and immobilization on fatty acid (FA) selectivity of Burkholderia (formerly Pseudomonas) cepacia, Rhizomucor miehei, Candida antarctica (type B), and Candida rugosa lipases in esterification reactions ..
  92. ncbi The out-of-hospital validation of the Canadian C-Spine Rule by paramedics
    Christian Vaillancourt
    Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Ann Emerg Med 54:663-671.e1. 2009
    ..This study prospectively evaluates the performance characteristics, reliability, and clinical sensibility of the Canadian C-Spine Rule when used by paramedics in the out-of-hospital setting...
  93. ncbi Deficit in human muscle strength with cast immobilization: contribution of inorganic phosphate
    Neeti C Pathare
    Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
    Eur J Appl Physiol 98:71-8. 2006
    Metabolic factors have been proposed to explain strength deficits observed in skeletal muscle with immobilization that are not completely accounted for by changes in muscle cross-sectional area (CSA) and neural adaptations...
  94. ncbi Effects of head immobilization on the coordination and control of head and body reorientation and translation during steering
    M A Hollands
    Neural Control Laboratory, Department of Kinesiology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Exp Brain Res 140:223-33. 2001
    ....
  95. ncbi Passive stretching does not enhance outcomes in patients with plantarflexion contracture after cast immobilization for ankle fracture: a randomized controlled trial
    Anne M Moseley
    School of Physiotherapy, University of Sydney, PO Box 170, Lidcombe NSW 1825, Sydney, Australia
    Arch Phys Med Rehabil 86:1118-26. 2005
    To compare the efficacy of short- and long-duration passive stretches with a control treatment for the management of plantarflexion contracture after cast immobilization for ankle fracture.
  96. ncbi Remifentanil for fetal immobilization and maternal sedation during fetoscopic surgery: a randomized, double-blind comparison with diazepam
    Marc Van de Velde
    Department of Anaesthesiology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Anesth Analg 101:251-8, table of contents. 2005
    ..In the absence of general anesthesia, fetal immobilization is not achieved...
  97. ncbi Bone mineral and geometric changes through the femur with immobilization due to spinal cord injury
    B J Kiratli
    Spinal Cord Injury Center, VA Palo Alto Health Care System, CA 94304, USA
    J Rehabil Res Dev 37:225-33. 2000
    ..and geometric properties of the midshaft and distal femur in a control population and examines effects of immobilization due to spinal cord injury (SCI) at these skeletal sites...
  98. ncbi Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization
    J Haapala
    Department of Surgery, University of Kuopio, Finland
    Int J Sports Med 21:76-81. 2000
    ..was to characterize the biomechanical and structural changes in canine knee cartilage after an initial 11-week immobilization and subsequent remobilization period of 50 weeks...
  99. pmc Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans
    T Hortobagyi
    Biomechanics Laboratory and Departments of Biochemistry and Physical Therapy, East Carolina University, Greenville, NC 27858, USA
    J Physiol 524:293-304. 2000
    ..and myosin heavy-chain (MyoHC) gene expression were examined in 48 men and women following 3 weeks of knee immobilization and after 12 weeks of retraining with 1866 eccentric, concentric or mixed contractions. 2...
  100. ncbi Early functional treatment versus early immobilization in tension of the musculotendinous unit after Achilles rupture repair: a prospective, randomized, clinical study
    Jarmo Kangas
    Department of Surgery, Oulu University Hospital, Finland
    J Trauma 54:1171-80; discussion 1180-1. 2003
    ..clinical study was to compare two postoperative regimens after Achilles rupture repair and determine whether early functional treatment will give a better result than early immobilization in tension of the musculotendinous unit.
  101. ncbi Dose-dependent effects of chemical immobilization on the heart rate of embryonic zebrafish
    Michael P Craig
    Department of Genome Science, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Lab Anim (NY) 35:41-7. 2006
    ..The results of this study empirically define, for the first time, effective, minimally stressful treatments for immobilization and in vivo visualization during early zebrafish development.

Research Grants83

  1. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..SCI require additional health care, which may be related to the degree of neurologic impairment or to chronic immobilization secondary to skeletal muscle paralysis...
  2. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
    ..for calcium flux, secretory response and cytokine production will correlate functional responses with receptor immobilization, clustering and desensitization...
  3. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget Wilson; Fiscal Year: 2009
    ..for calcium flux, secretory response and cytokine production will correlate functional responses with receptor immobilization, clustering and desensitization...
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2005
    ..molecules in response to allergic triggers, as well as by direct nerve stimulation and by acute immobilization stress...
  5. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2004
    ..molecules in response to allergic triggers, as well as by direct nerve stimulation and by acute immobilization stress...
  6. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2003
    ..molecules in response to allergic triggers, as well as by direct nerve stimulation and by acute immobilization stress...
  7. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..molecules in response to allergic triggers, as well as by direct nerve stimulation and by acute immobilization stress...
  8. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..Joint Immobilization Study: Atrophic articular cartilage containing chondrocytes with minimal synthetic activity will be produced ..
  9. Polarization and directed cell movements in engineered cellular environments
    Deborah Leckband; Fiscal Year: 2009
    ..team possesses core competencies in microfabrication (Nuzzo), surface modification and protein immobilization (Leckband), biochemical/cell biological techniques (Wang), as well as expertise in cadherin biology (Leckband) ..
  10. Polarization and directed cell movements in engineered cellular environments
    Deborah E Leckband; Fiscal Year: 2010
    ..team possesses core competencies in microfabrication (Nuzzo), surface modification and protein immobilization (Leckband), biochemical/cell biological techniques (Wang), as well as expertise in cadherin biology (Leckband) ..
  11. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2004
    ..triggers, mast cells can also be activated by direct nerve stimulation, by neuropeptides, and by acute immobilization stress through the local release of corticotropin releasing hormone (CRH) or urocortin (Ucn), which is more ..
  12. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
    ..triggers, mast cells can also be activated by direct nerve stimulation, by neuropeptides, and by acute immobilization stress through the local release of corticotropin releasing hormone (CRH) or urocortin (Ucn), which is more ..
  13. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2001
    ..triggers, mast cells can also be activated by direct nerve stimulation, by neuropeptides, and by acute immobilization stress through the local release of corticotropin releasing hormone (CRH) or urocortin (Ucn), which is more ..
  14. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2002
    ..triggers, mast cells can also be activated by direct nerve stimulation, by neuropeptides, and by acute immobilization stress through the local release of corticotropin releasing hormone (CRH) or urocortin (Ucn), which is more ..
  15. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2003
    ..triggers, mast cells can also be activated by direct nerve stimulation, by neuropeptides, and by acute immobilization stress through the local release of corticotropin releasing hormone (CRH) or urocortin (Ucn), which is more ..
  16. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2010
    ..Two of our recent technological innovations, ultrafast laser nanosurgery and microfluidics immobilization have made it feasible to study axonal regeneration in this genetically tractable model organism...
  17. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2009
    ..Two of our recent technological innovations, ultrafast laser nanosurgery and microfluidics immobilization have made it feasible to study axonal regeneration in this genetically tractable model organism...
  18. Integrated Microfluidics for Nerve Regeneration Studies using Laser Nano-Axotomy
    Adela Ben Yakar; Fiscal Year: 2007
    ..This microfluidic trap will facilitate the appropriate immobilization of the animals for precision nanosurgery of axons using femtosecond laser pulses and for imaging the re-growth ..
  19. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 1999
    ..Acute psychological stress by immobilization triggered dura mast cell degranulation and resulted in cerebrospinal fluid (CSF) increase of rat mast cell ..
  20. Glucocorticoid control of gene expression during skeletal muscle atrophy
    J DAVID contact FURLOW; Fiscal Year: 2010
    ..David Skeletal muscle wasting, or atrophy, is a major human health concern. Immobilization, nerve damage, cachexia, sepsis, and aging induce significant and potentially life-threatening losses in ..
  21. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..Acute psychological stress by immobilization triggered dura mast cell degranulation and resulted in cerebrospinal fluid (CSF) increase of rat mast cell ..
  22. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2000
    ..Acute psychological stress by immobilization triggered dura mast cell degranulation and resulted in cerebrospinal fluid (CSF) increase of rat mast cell ..
  23. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2009
    ..normal and end-stage CKD patients, CKD rats with muscle wasting, and CKD rats with disuse atrophy induced by immobilization. Specific Aim 1. To evaluate the effect of uremia on GH mediated signal transduction in human skeletal muscle...
  24. Tear-Resistant and Elastic Tissue Adhesive for Craniofacial Applications
    SILVIA D LUEBBEN; Fiscal Year: 2012
    ..cannot be used to repair deep dermal cuts or to close wounds that are under tensions unless sutures and/or immobilization are also used...
  25. Realtime Monitoring of Trace Amounts of Pesticides from Water Using Carbo
    ANNE M contact SCHWARTZ; Fiscal Year: 2010
    ..We propose to use carbon nanotube matrices as the active biosensor area for the effective immobilization of the pesticides through antibody based conjugation...
  26. Heat shock proteins and disuse muscle atrophy
    Andrew Judge; Fiscal Year: 2009
    ..summary/Abstract Skeletal muscle disuse atrophy is a widespread physiological phenomenon associated with immobilization, bed rest, denervation, and space flight, or any general reduction in weight bearing activity...
  27. Heat shock proteins and disuse muscle atrophy
    ANDREW ROBERT JUDGE; Fiscal Year: 2010
    ..summary/Abstract Skeletal muscle disuse atrophy is a widespread physiological phenomenon associated with immobilization, bed rest, denervation, and space flight, or any general reduction in weight bearing activity...
  28. JOINT CONTRACTURE: BIOMECHANICAL-CHEMICAL CORRELATES
    Wayne Akeson; Fiscal Year: 1980
    ..of fibrous connective tissue have been demonstrated in experimental joint contractures as a result of immobilization. These changes were uniformly observed in ligaments, tendons, fascia and capsular tissue of the knee joint...
  29. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily ..
  30. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2007
    Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living...
  31. REGULATION OF SKELETAL MUSCLE METABOLISM
    Leonard S Jefferson; Fiscal Year: 2011
    ..lead to loss of muscle mass including sedentary life styles, chronic bed rest, casting, limb suspension, and immobilization. Each of these inactivity-related conditions is thought to share a common feature, i.e...
  32. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2006
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  33. Development of a 3D mammotomograph with novel techniques to overcome limitations
    Randolph L McKinley; Fiscal Year: 2010
    ..cancer patients for three purposes: (1) evaluation of a developed simple mechanism for uncompressed breast immobilization and biopsy capability;(2) evaluation of modified system on women of varying breast and body sizes to confirm ..
  34. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    ..Since the 1940s, in vivo toxic metal immobilization has involved the use of ethylenediamine-tetraacetate (EDTA) or dimercaptosuccinic acid (DMSA) following metal ..
  35. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2000
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  36. Development of a 3D mammotomograph with novel techniques to overcome limitations
    RANDOLPH MCKINLEY; Fiscal Year: 2009
    ..cancer patients for three purposes: (1) evaluation of a developed simple mechanism for uncompressed breast immobilization and biopsy capability;(2) evaluation of modified system on women of varying breast and body sizes to confirm ..
  37. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2001
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  38. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2003
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  39. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2000
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  40. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2002
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  41. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2003
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  42. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2004
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  43. SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTION
    Hugh C Hemmings; Fiscal Year: 2011
    ..of anesthetic action is insufficient to explain how any anesthetic produces amnesia, unconsciousness or immobilization (with increasing doses), the cardinal features of general anesthesia...
  44. Phase 2 REAL-TIME MONITORING OF TRACE AMOUNTS OF PESTICIDES IN WATER AND FOOD USI
    ANNE M SCHWARTZ; Fiscal Year: 2012
    ..We propose to further develop the carbon nanotube matrices active biosensor area for effective immobilization of multiple pesticides, as well as preservation and manufacturing specifications of the sensors...
  45. EFFECTS OF IMMOBILIZATION OF BONE & MINERAL HOMEOSTASIS
    Russell Turner; Fiscal Year: 1992
    Disuse causes osteolysis of the skeleton, with attendant hypercalcemia, hypercalciuria and osteoporosis. Immobilization with a cast and stress shielding by an orthopedic implant result in localized bone loss...
  46. Bioadhesive Membrane Construct for Hernia Repair
    YURI WILLIAM NOVITSKY; Fiscal Year: 2010
    ..Equally important, effective immobilization of the mesh against the abdominal wall is critical to hernia repair success...
  47. Bioadhesive Membrane Construct for Hernia Repair
    Bruce Lee; Fiscal Year: 2009
    ..Equally important, effective immobilization of the mesh against the abdominal wall is critical to hernia repair success...
  48. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey D Esko; Fiscal Year: 2010
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  49. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2009
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  50. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey Esko; Fiscal Year: 2007
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  51. Microbubble Infused Hydrogels for Cartilage Tissue Engineering
    Clark T Hung; Fiscal Year: 2012
    ..generates micropores that are homogeneously distributed within the gels, while enabling the direct ab initio immobilization of cels within the gels...
  52. HYBRID ARTIFICIAL LIVER USING IMMOBILIZED HEPATOCYTES
    Ronald Tompkins; Fiscal Year: 1990
    The objective is the immobilization of hepatocytes for use in an artificial liver device. Hepatocytes will be isolated by established techniques using collagenase digestion and immobilized in a sodium alginate gel matrix...
  53. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2004
    ..It has been found that spastic muscles have increased type I (slow) fibers. Cerebral palsy, joint immobilization and tenotomy, three very different original conditions which cause muscle contracture, have a common ..
  54. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2005
    ..It has been found that spastic muscles have increased type I (slow) fibers. Cerebral palsy, joint immobilization and tenotomy, three very different original conditions which cause muscle contracture, have a common ..
  55. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2003
    ..It has been found that spastic muscles have increased type I (slow) fibers. Cerebral palsy, joint immobilization and tenotomy, three very different original conditions which cause muscle contracture, have a common ..
  56. IMMUNOBIOLOGICAL ROLE OF FERTILIZATION ANTIGEN (FA-1)
    RAJESH NAZ; Fiscal Year: 1990
    ..hamster ova and inhibited in vitro fertilization of mouse ova by murine sperm without causing agglutination or immobilization of sperm...
  57. Attenuation of denervation atrophy by nandrolone: molecular mechanisms
    Christopher Cardozo; Fiscal Year: 2009
    ..A significant impediment to rehabilitation is muscle atrophy as a consequence of paralysis, immobilization, medications, and chronic illness...
  58. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2003
    ..produce a scanner capable of 10 second breast scanning, and the scanner development will also include a breast immobilization system (acrylic cylinders), a breast CT table, a fast reconstruction computer, and a computer workstation ..
  59. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..produce a scanner capable of 10 second breast scanning, and the scanner development will also include a breast immobilization system (acrylic cylinders), a breast CT table, a fast reconstruction computer, and a computer workstation ..
  60. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2005
    ..produce a scanner capable of 10 second breast scanning, and the scanner development will also include a breast immobilization system (acrylic cylinders), a breast CT table, a fast reconstruction computer, and a computer workstation ..
  61. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2006
    ..produce a scanner capable of 10 second breast scanning, and the scanner development will also include a breast immobilization system (acrylic cylinders), a breast CT table, a fast reconstruction computer, and a computer workstation ..
  62. Effect of Stress on Glutamate Receptors and Signaling Proteins in the Basolateral
    EMIL MULY; Fiscal Year: 2009
    ..We will use a rodent model of repeated, severe stress- repeated immobilization stress to study the effect of stress in the BLA...
  63. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2004
    ..produce a scanner capable of 10 second breast scanning, and the scanner development will also include a breast immobilization system (acrylic cylinders), a breast CT table, a fast reconstruction computer, and a computer workstation ..
  64. Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating B
    JOSEPH MK IRUDAYARAJ; Fiscal Year: 2010
    ..metal ion-reducing bacteria (DMRB) remain potent, potentially cost-effective approaches to the reductive immobilization or detoxification of environmental contaminants...
  65. Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating B
    Joseph Irudayaraj; Fiscal Year: 2009
    ..metal ion-reducing bacteria (DMRB) remain potent, potentially cost-effective approaches to the reductive immobilization or detoxification of environmental contaminants...
  66. Therapeutic Strategies to Augment Muscle Rehabilitation
    Krista Vandenborne; Fiscal Year: 2009
    ..to promote muscle regeneration and hypertrophy following disuse/unloading after hindlimb suspension and cast immobilization (collaboration with Project 1, and Cores A, B, and C)...
  67. Localized immobilization of ephrin-B2 for neurite guidance in 3D culture
    Michael J Moore; Fiscal Year: 2010
    ..we propose the following specific aims: Aim 1: Synthesize a photo-labile peptide hydrogel for localized immobilization of protein ligands...
  68. Localized immobilization of ephrin-B2 for neurite guidance in 3D culture
    Michael Moore; Fiscal Year: 2009
    ..we propose the following specific aims: Aim 1: Synthesize a photo-labile peptide hydrogel for localized immobilization of protein ligands...
  69. An Endothelial Progenitor Cell-Specific Nanofibrous Vascular Graft
    Lisa Fitzgerald; Fiscal Year: 2009
    ..synthesize and characterize in vitro a novel nanofibrous vascular graft material using our electrospinning and immobilization technology that would direct rapid adhesion and subsequent growth of circulating progenitor and more mature ..
  70. Rotator cuff tendon to bone insertion site healing
    LOUIS SOSLOWSKY; Fiscal Year: 2009
    ..b>Immobilization was found to result in better healing than either cage activity or exercise and the longer the period of ..
  71. Rotator cuff tendon to bone insertion site healing
    LOUIS SOSLOWSKY; Fiscal Year: 2007
    ..b>Immobilization was found to result in better healing than either cage activity or exercise and the longer the period of ..
  72. Rotator cuff tendon to bone insertion site healing
    Louis J Soslowsky; Fiscal Year: 2010
    ..b>Immobilization was found to result in better healing than either cage activity or exercise and the longer the period of ..
  73. Rotator cuff tendon to bone insertion site healing
    LOUIS SOSLOWSKY; Fiscal Year: 2006
    ..b>Immobilization was found to result in better healing than either cage activity or exercise and the longer the period of ..
  74. Porous Glass-Ceramics for Protein Purification/ immobili
    Steven Morgan; Fiscal Year: 2001
    ..of these glass-ceramics can produce porous materials which can be used as matrices for the purification and/or immobilization of biomolecules...
  75. IMMOBILIZED CELL FREE TRANSLATION SYSTEM
    William Scouten; Fiscal Year: 1992
    ..in a way, an extension of the investigators laboratory's interest in solid phase biochemistry and biomolecule immobilization. The investigators will formulate their initial attempts to prepare an immobilized protein synthesis system ..
  76. IMMOBILIZED CELL FREE TRANSLATION SYSTEMS
    William Scouten; Fiscal Year: 1992
    ..in a way, an extension of the investigators laboratory's interest in solid phase biochemistry and biomolecule immobilization. The investigators will formulate their initial attempts to prepare an immobilized protein synthesis system ..
  77. Digital tomosynthesis: a new paradigm for radiation treatment verification
    Fang Fang Yin; Fiscal Year: 2007
    ..g. breast), or those with substantial immobilization or support devices; 3) A high radiation dose (2-9 cGy) is delivered to the imaged volume with current imaging ..
  78. Biomedical Polymers With Heparin-Binding End Groups
    Robert Ward; Fiscal Year: 2004
    Endpoint immobilization of heparin on the surface of polymeric biomaterials is a well-established method for improving thrombo-resistance...