immobilization

Summary

Summary: The restriction of the MOVEMENT of whole or part of the body by physical means (RESTRAINT, PHYSICAL) or chemically by ANALGESIA, or the use of TRANQUILIZING AGENTS or NEUROMUSCULAR NONDEPOLARIZING AGENTS. It includes experimental protocols used to evaluate the physiologic effects of immobility.

Top Publications

  1. doi Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo
    Annika Burleigh
    Department of Cell Signaling, Kennedy Institute of Rheumatology, University of Oxford, London, UK
    Arthritis Rheum 64:2278-88. 2012
  2. pmc Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
    Arkan Abadi
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6518. 2009
  3. doi Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
    Agostino Gaudio
    Department of Internal Medicine, University of Catania, 95124 Catania, Italy
    J Clin Endocrinol Metab 95:2248-53. 2010
  4. ncbi The role of NF-kappaB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Ann N Y Acad Sci 1057:431-47. 2005
  5. doi Comparison of Macintosh, Truview EVO2, Glidescope, and Airwayscope laryngoscope use in patients with cervical spine immobilization
    M A Malik
    Department of Anaesthesia, Clinical Sciences Institute, Galway University Hospitals, Galway, Ireland
    Br J Anaesth 101:723-30. 2008
  6. ncbi Immobilization stress induces BDNF in rat submandibular glands
    K Tsukinoki
    Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College, 82 Inaoka cho, Yokosuka, Kanagawa 238 8580, Japan
    J Dent Res 85:844-8. 2006
  7. ncbi Covalent immobilization of proteins for the biosensor based on imaging ellipsometry
    Zhan Hui Wang
    National Microgravity Laboratory, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, PR China
    J Immunol Methods 285:237-43. 2004
  8. doi Two-week cast immobilization induced chronic widespread hyperalgesia in rats
    Y Ohmichi
    Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Aichi, 480 1195, Japan
    Eur J Pain 16:338-48. 2012
  9. ncbi The effects of rigid collar placement on intracranial and cerebral perfusion pressures
    K Hunt
    The National Hospital for Neurology and Neurosurgery, Centre for Anaesthesia, University College London Hospitals, Queen Square, London WC1N 3BG, UK
    Anaesthesia 56:511-3. 2001
  10. doi Effects of limb immobilization on brain plasticity
    N Langer
    Division of Neuropsychology, Institute of Psychology, and International Normal Aging and Plasticity Imaging Center, University of Zurich, Zurich, Switzerland
    Neurology 78:182-8. 2012

Detail Information

Publications353 found, 100 shown here

  1. doi Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo
    Annika Burleigh
    Department of Cell Signaling, Kennedy Institute of Rheumatology, University of Oxford, London, UK
    Arthritis Rheum 64:2278-88. 2012
    ..This study was undertaken to investigate the link between protease expression and mechanical joint loading in vivo...
  2. pmc Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
    Arkan Abadi
    Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e6518. 2009
    ..The purpose of this study was to examine changes in global gene transcription during immobilization-induced muscle atrophy in humans and then explore the effects of the most prominent transcriptional ..
  3. doi Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
    Agostino Gaudio
    Department of Internal Medicine, University of Catania, 95124 Catania, Italy
    J Clin Endocrinol Metab 95:2248-53. 2010
    ..Sclerostin, a Wnt signaling antagonist on the osteoblasts produced by osteocytes, is regulated by mechanical strain and is implicated in the pathogenesis of disuse bone loss. There are no data on sclerostin in humans...
  4. ncbi The role of NF-kappaB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Ann N Y Acad Sci 1057:431-47. 2005
    ..The molecular mechanisms responsible for the muscle protein breakdown during immobilization in aging have been studied in our laboratory in a model of 24-month-old Wistar rats, immobilized for 4 weeks...
  5. doi Comparison of Macintosh, Truview EVO2, Glidescope, and Airwayscope laryngoscope use in patients with cervical spine immobilization
    M A Malik
    Department of Anaesthesia, Clinical Sciences Institute, Galway University Hospitals, Galway, Ireland
    Br J Anaesth 101:723-30. 2008
    ..of the Pentax AWS, Glidescope, and the Truview EVO2, in comparison with the Macintosh laryngoscope, when performing tracheal intubation in patients with neck immobilization using manual in-line axial cervical spine stabilization.
  6. ncbi Immobilization stress induces BDNF in rat submandibular glands
    K Tsukinoki
    Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College, 82 Inaoka cho, Yokosuka, Kanagawa 238 8580, Japan
    J Dent Res 85:844-8. 2006
    ..b>Immobilization stress modifies BDNF mRNA expression in some organs...
  7. ncbi Covalent immobilization of proteins for the biosensor based on imaging ellipsometry
    Zhan Hui Wang
    National Microgravity Laboratory, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, PR China
    J Immunol Methods 285:237-43. 2004
    In the development of biosensors, the immobilization of biomolecules at interfaces played a crucial role...
  8. doi Two-week cast immobilization induced chronic widespread hyperalgesia in rats
    Y Ohmichi
    Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Aichi, 480 1195, Japan
    Eur J Pain 16:338-48. 2012
    It has been postulated that physical immobilization is an essential factor in developing chronic pain after trauma or surgery in an extremity...
  9. ncbi The effects of rigid collar placement on intracranial and cerebral perfusion pressures
    K Hunt
    The National Hospital for Neurology and Neurosurgery, Centre for Anaesthesia, University College London Hospitals, Queen Square, London WC1N 3BG, UK
    Anaesthesia 56:511-3. 2001
    ..These findings suggest that in head-injured patients, rigid collars should be removed as soon as cervical spine injury has been excluded or, if this is delayed, an alternative method of spinal stabilisation considered...
  10. doi Effects of limb immobilization on brain plasticity
    N Langer
    Division of Neuropsychology, Institute of Psychology, and International Normal Aging and Plasticity Imaging Center, University of Zurich, Zurich, Switzerland
    Neurology 78:182-8. 2012
    ..Therefore, we conducted a longitudinal study to investigate whether limb immobilization after unilateral arm injury is reflected in structural plastic changes in gray matter (cortical thickness) and ..
  11. pmc Long-term imaging of Caenorhabditis elegans using nanoparticle-mediated immobilization
    Eric Kim
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e53419. 2013
    ..Imaging C. elegans often requires animals to be immobilized to avoid movement-related artifacts. Immobilization has been performed by application of anesthetics or by introducing physical constraints using glue or ..
  12. ncbi Long-lasting cervical radicular pain managed with surgery, physiotherapy, or a cervical collar. A prospective, randomized study
    L C Persson
    Department of Neurosurgery, University Hospital, Lund, Sweden
    Spine (Phila Pa 1976) 22:751-8. 1997
    ..CONCLUSIONS: In the treatment of patients with long-lasting cervical radicular pain, it appears that a cervical collar, physiotherapy, or surgery are equally effective in the long term...
  13. doi Effects of aging on human skeletal muscle after immobilization and retraining
    C Suetta
    Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 NV Copenhagen, Denmark
    J Appl Physiol (1985) 107:1172-80. 2009
    ..on skeletal muscle in young individuals are well elucidated, only little is known about the consequence of immobilization and the regenerative capacity in elderly individuals...
  14. ncbi Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization
    Ian A F Stokes
    Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont 05405, USA
    Spine (Phila Pa 1976) 29:2724-32. 2004
    A review of the literature on macromechanical factors that accelerate disc degeneration with particular focus on distinguishing the roles of immobilization and overloading.
  15. ncbi Submandibular glands contribute to increases in plasma BDNF levels
    K Tsukinoki
    Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    J Dent Res 86:260-4. 2007
    ..Expression of BDNF mRNA has been identified in the submandibular glands when male rats are exposed to acute immobilization stress...
  16. ncbi Repositioning accuracy of two different mask systems-3D revisited: comparison using true 3D/3D matching with cone-beam CT
    Judit Boda-Heggemann
    Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany
    Int J Radiat Oncol Biol Phys 66:1568-75. 2006
    ..We analyzed the accuracy of commercially available head mask systems, using true 3D/3D matching, with X-ray volume imaging and cone-beam CT...
  17. ncbi Halo vest immobilization in the elderly: a death sentence?
    Sarah Majercik
    Division of Trauma and Surgical Critical Care, Rhode Island Hospital Brown Medical School, Providence, Rhode Island, USA
    J Trauma 59:350-6; discussion 356-8. 2005
    ..In many centers, halo vest immobilization (HVI) is the treatment of choice...
  18. doi Position and duration of immobilization after primary anterior shoulder dislocation: a systematic review and meta-analysis of the literature
    William H Paterson
    Campbell Clinic University of Tennessee Department of Orthopaedics, 1211 Union Avenue, Suite 500, Memphis, TN 38104, USA
    J Bone Joint Surg Am 92:2924-33. 2010
    b>Immobilization after closed reduction has long been the standard treatment for primary anterior dislocation of the shoulder...
  19. doi Immobilization in external rotation after primary shoulder dislocation did not reduce the risk of recurrence: a randomized controlled trial
    Sigurd Liavaag
    Department of Orthopedic Surgery, Sørlandet Hospital, Service Box 605, 4809 Arendal, Norway
    J Bone Joint Surg Am 93:897-904. 2011
    The treatment of primary traumatic anterior shoulder dislocation varies widely from no immobilization, to two or three weeks of immobilization in internal rotation with the arm in a sling, to treatment with a brace in external rotation...
  20. ncbi Effects of prehospital spinal immobilization: a systematic review of randomized trials on healthy subjects
    Irene Kwan
    National Collaborating Centre for Women s and Children s Health, Royal College of Obstetricians and Gynecologists, London, England, UK
    Prehosp Disaster Med 20:47-53. 2005
    To evaluate the effects of spinal immobilization on healthy participants.
  21. ncbi Functional outcome and risk of recurrent instability after primary traumatic anterior shoulder dislocation in young patients
    C Michael Robinson
    The New Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh EH16 4SU, Scotland
    J Bone Joint Surg Am 88:2326-36. 2006
    ..We also aimed to produce guidelines for the design of future clinical trials, assessing the efficacy of interventions designed to improve the outcome after a primary dislocation...
  22. doi Effects of 3 days unloading on molecular regulators of muscle size in humans
    T Gustafsson
    Department of Laboratory Medicine, Section of Clinical Physiology, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden
    J Appl Physiol (1985) 109:721-7. 2010
    ..Further, the reported difference in gene expression pattern across muscles suggests that mechanisms regulating protein content in human skeletal muscle are influenced by phenotype and/or function...
  23. pmc Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy
    Kisuk Min
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol (1985) 111:1459-66. 2011
    Prolonged periods of muscular inactivity (e.g., limb immobilization) result in skeletal muscle atrophy...
  24. ncbi Oral administration of Cimicifuga racemosa extract affects immobilization stress-induced changes in murine cerebral monoamine metabolism
    Isao Nadaoka
    Research Laboratories for Fundamental Technology of Food, Asahi Group Holdings, Ltd, 1 21, Midori 1 chome, Moriya shi, Ibaraki, 302 0106, Japan
    Biomed Res 33:133-7. 2012
    ..acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA), and plasma corticosterone in mice subjected to acute immobilization stress...
  25. doi Compression therapy promotes proliferative repair during rat Achilles tendon immobilization
    Nikos Schizas
    Orthopaedic Laboratory, Department of Molecular Medicine and Surgery, M1 02, The King Gustav V Research Building, Karolinska University Hospital 171 76 Stockholm, Sweden
    J Orthop Res 28:852-8. 2010
    Achilles tendon ruptures are treated with an initial period of immobilization, which obstructs the healing process partly by a reduction of blood circulation...
  26. doi Setup uncertainties of anatomical sub-regions in head-and-neck cancer patients after offline CBCT guidance
    Simon van Kranen
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 73:1566-73. 2009
    ..To quantify local geometrical uncertainties in anatomical sub-regions during radiotherapy for head-and-neck cancer patients...
  27. doi Chronic immobilization stress alters aspects of emotionality and associative learning in the rat
    Gwendolyn E Wood
    The Laboratory of Neuroendocrinology The Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:282-92. 2008
    ..Chronic immobilization stress (CIS) induces anxiety behavior and dendritic hypertrophy in the basolateral amygdala, which persist ..
  28. doi Immobilization stress induces endothelial dysfunction by oxidative stress via the activation of the angiotensin II/its type I receptor pathway
    Ick Mo Chung
    Division of Cardiology, Department of Internal Medicine, Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
    Atherosclerosis 213:109-14. 2010
    ..We here studied the mechanism by which immobilization stress causes endothelial dysfunction with specific aim of identifying the role of angiotensin II and its type ..
  29. ncbi Odontoid fractures in the elderly: dorsal C1/C2 fusion is superior to halo-vest immobilization
    Thomas M Frangen
    Department of Surgery, Kliniken Bergmannsheil, Ruhr University, Bochum, Germany
    J Trauma 63:83-9. 2007
    ..Recent studies confirmed that external stabilization with halo-vest immobilization is associated with high complication rates and mortality...
  30. pmc Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation
    Shimei Zhu
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Room 206, 5l Blossom Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 47:711-21. 2013
    b>Immobilization by casting induces disuse muscle atrophy (DMA).
  31. doi Active non-operative treatment of acute isolated posterior cruciate ligament injury with cylinder cast immobilization
    Young Bok Jung
    Department of Orthopedic Surgery, Chung Ang Medical Center, Heukseok dong 224 1, Dongjak Gu, Seoul, South Korea
    Knee Surg Sports Traumatol Arthrosc 16:729-33. 2008
    ..non-operative treatment of the acute isolated posterior cruciate ligament (PCL) injury using cylinder cast immobilization and brace with tibial supporter...
  32. doi Cone-beam CT assessment of interfraction and intrafraction setup error of two head-and-neck cancer thermoplastic masks
    Michael Velec
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 76:949-55. 2010
    ..To prospectively compare setup error in standard thermoplastic masks and skin-sparing masks (SSMs) modified with low neck cutouts for head-and-neck intensity-modulated radiation therapy (IMRT) patients...
  33. doi Removing a patient from the spine board: is the lift and slide safer than the log roll?
    Marybeth Horodyski
    Department of Orthopaedic Surgery, University of Florida, Gainesville, Florida, USA
    J Trauma 70:1282-5; discussion 1285. 2011
    After spine board immobilization of the trauma victim and transport to the hospital, the patient is removed from the spine board as soon as practical...
  34. doi Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model
    Daniel K I Bring
    Section of Orthopaedics and Sports Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 27:274-80. 2009
    Healing after mobilization versus immobilization was assessed in a model of rat Achilles tendon rupture, by RT-PCR at 8 and 17 days and by histological analyses at 14 and 28 days postrupture...
  35. doi Inter- and intrafraction patient positioning uncertainties for intracranial radiotherapy: a study of four frameless, thermoplastic mask-based immobilization strategies using daily cone-beam CT
    Erik Tryggestad
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 80:281-90. 2011
    To determine whether frameless thermoplastic mask-based immobilization is adequate for image-guided cranial radiosurgery.
  36. ncbi A practical method to achieve prostate gland immobilization and target verification for daily treatment
    A V D'Amico
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 51:1431-6. 2001
    A practical method to achieve prostate immobilization and daily target localization for external beam radiation treatment is described.
  37. ncbi Enhancement of adenoviral gene transfer to adult rat cardiomyocytes in vivo by immobilization and ultrasound treatment of the heart
    M Sato
    Department of Cardiac Medicine, NHLI Division, Imperial College London, UK
    Gene Ther 12:936-41. 2005
    ..Brief immobilization of the ventricle during and after injection using a haemoclip increased the number of transfected rod-shaped, ..
  38. doi Failure of the interosseous membrane to heal with immobilization, pinning of the distal radioulnar joint, and bipolar radial head replacement in a case of Essex-Lopresti injury: case report
    Hyun Sik Gong
    Department of Orthopaedics, Hand and Upper Extremity Service, Seoul National University Bundang Hospital, Seongnam, Korea
    J Hand Surg Am 35:976-80. 2010
    ..This case demonstrates that failure of the interosseous membrane can occur even in a properly replaced bipolar radial head with adequate immobilization of the forearm and pinning of the distal radioulnar joint.
  39. doi Strength training the free limb attenuates strength loss during unilateral immobilization
    Jonathan P Farthing
    College of Kinesiology, Univ of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Appl Physiol (1985) 106:830-6. 2009
    The objective was to determine if strength training the free limb during a 3-wk period of unilateral immobilization attenuates strength loss in the immobilized limb through cross-education...
  40. doi Random positional variation among the skull, mandible, and cervical spine with treatment progression during head-and-neck radiotherapy
    Peter H Ahn
    Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA
    Int J Radiat Oncol Biol Phys 73:626-33. 2009
    With 54 degrees of freedom from the skull to mandible to C7, ensuring adequate immobilization for head-and-neck radiotherapy (RT) is complex. We quantify variations in skull, mandible, and cervical spine movement between RT sessions.
  41. doi Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnover
    Michael J Rennie
    University of Nottingham, School of Graduate Entry Medicine and Health, City Hospital, Derby, DE22 3DT, UK
    Appl Physiol Nutr Metab 34:377-81. 2009
    ..Exercise may retune the amino acid and (or) insulin sensitivity of muscle in older people...
  42. ncbi Short-term immobilization after eccentric exercise. Part II: creatine kinase and myoglobin
    Stephen P Sayers
    Human Physiology Laboratory, Department of Health Sciences, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Avenue, Boston, MA 02215, USA
    Med Sci Sports Exerc 35:762-8. 2003
    ..We previously found short-term immobilization blunted the rise in plasma CK after eccentric exercise, suggesting subsequent movement of damaged muscle may ..
  43. ncbi Single and repeated immobilization stress differentially trigger induction and phosphorylation of several transcription factors and mitogen-activated protein kinases in the rat locus coeruleus
    Meleik A Hebert
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurochem 95:484-98. 2005
    ..Rats were exposed to single or repeated immobilization stress (IMO) for brief (5 min), intermediate (30 min) or sustained (2 h) duration...
  44. doi An inexpensive and simple method for thermally stable immobilization of DNA on an unmodified glass surface: UV linking of poly(T)10-poly(C)10-tagged DNA probes
    Haukur Gudnason
    DTU Nanotech, Department of Micro and Nanotechnology, Technical University of Denmark, Lyngby
    Biotechniques 45:261-71. 2008
    ..In conclusion, our results show that using TC-tagged DNA probes immobilized on an unmodified glass surface is a robust, heat-stable, very simple, and inexpensive method for manufacturing DNA microarrays...
  45. ncbi Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1397-406. 2006
    ..We conclude that some aromatic anesthetics may produce immobility in the face of noxious stimulation by blocking the action of glutamate on NMDA receptors but that conventional inhaled anesthetics do not...
  46. doi Effects of cross-education on the muscle after a period of unilateral limb immobilization using a shoulder sling and swathe
    Charlene R A Magnus
    College of Kinesiology, University of Saskatchewan, 87 Campus Dr, Saskatoon, SK S7N 5B2, Canada
    J Appl Physiol (1985) 109:1887-94. 2010
    The purpose of this study was to apply cross-education during 4 wk of unilateral limb immobilization using a shoulder sling and swathe to investigate the effects on muscle strength, muscle size, and muscle activation...
  47. pmc Robotic-based carbon ion therapy and patient positioning in 6 degrees of freedom: setup accuracy of two standard immobilization devices used in carbon ion therapy and IMRT
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 7:51. 2012
    ..particle radiotherapy in 6 degrees of freedom (DOF) and intensity-modulated radiotherapy (IMRT, 3 DOF) for two immobilization devices (Scotchcast masks vs thermoplastic head masks) currently in use at our institution for fractionated ..
  48. doi Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining
    Lars Hvid
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 109:1628-34. 2010
    ..Thus the purpose of this study was to investigate the effects of 2 wk of immobilization followed by 4 wk of retraining on knee extensor muscle mechanical function (e.g...
  49. ncbi Comparison of setup accuracy of three different thermoplastic masks for the treatment of brain and head and neck tumors
    L Gilbeau
    Radiation Oncology Department, , St-Luc University Hospital, 10 Ave. Hippocrate, B-1200 Brussels, Belgium
    Radiother Oncol 58:155-62. 2001
    ..The purpose of this study was to compare the setup accuracy of three different thermoplastic masks used for immobilization of patients with brain or head and neck tumors...
  50. doi Exercise and immobilization in aging animals: the involvement of oxidative stress and NF-kappaB activation
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Free Radic Biol Med 44:202-14. 2008
    ..Its involvement in exercise and immobilization has been demonstrated in several studies, indicating that these conditions may lead to inflammatory responses ..
  51. doi Neural responses in rat brain during acute immobilization stress: a [F-18]FDG micro PET imaging study
    Kang Keyng Sung
    Department of Neuroscience and Oriental Medicine, Wonkwang University, Iksan, South Korea
    Neuroimage 44:1074-80. 2009
    ..Animals were given immobilization stress for 1 or 2 h, or 1-h stress followed by 1-h recovery, after which their brains were scanned...
  52. doi Immediate-early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c-fos mRNA to adaptation
    Sheila Ons
    Department of Cellular Biology, Physiology and Immunology, Institute of Neuroscience and Animal Physiology Unit, School of Biosciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    Eur J Neurosci 31:2043-52. 2010
    ..and arc (activity-regulated cytoskeleton-associated protein) after repeated exposure to a severe stressor: immobilization on wooden boards (IMO)...
  53. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
  54. ncbi The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions
    B Vanwanseele
    Laboratory for Biomechanics, Swiss Federal Institute of Technology Zurich ETHZ, CH 8952 Schlieren, Switzerland
    Osteoarthritis Cartilage 10:408-19. 2002
    The purpose of this paper is to review current data and concepts concerning the effect of immobilization on articular cartilage in animal models. We also evaluate the methods to measure articular cartilage changes in humans.
  55. ncbi Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin
    M Denda
    Life Science Research Laboratories, Shiseido Research Center 2, Yokohama, Japan
    Br J Dermatol 138:780-5. 1998
    To examine the effect of stress on skin homeostasis, cutaneous barrier recovery was measured in rate exposed to immobilization stress after tape stripping or sodium dodecyl sulphate treatment...
  56. ncbi Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element
    Takuro Yamamoto
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:42036-43. 2005
    ....
  57. doi Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex
    Yeon Joo
    Department of Anatomy and Neurobiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Neurosci Lett 461:121-5. 2009
    ..Mice were subjected to immobilization stress for 2h per day for 15 consecutive days and the behavior of the mice was examined...
  58. doi Tracheal intubation in patients with cervical spine immobilization: a comparison of the Airwayscope, LMA CTrach, and the Macintosh laryngoscopes
    M A Malik
    Department of Anaesthesia, Galway University Hospitals, Galway, Ireland
    Br J Anaesth 102:654-61. 2009
    ..the effectiveness of the Pentax AWS, and the LMA CTrach, in comparison with the Macintosh laryngoscope, when performing tracheal intubation in patients with neck immobilization using manual in-line axial cervical spine stabilization.
  59. doi The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans
    K Sakuma
    Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, Toyohashi, Japan
    Acta Physiol (Oxf) 197:151-9. 2009
    ....
  60. ncbi Acute treatment of inversion ankle sprains: immobilization versus functional treatment
    Morgan H Jones
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Orthop Relat Res 455:169-72. 2007
    ..We conducted a systematic review of the literature to evaluate the effect of immobilization versus early functional treatment on time to return to preinjury activity after inversion ankle sprain...
  61. ncbi Out-of-hospital spinal immobilization: its effect on neurologic injury
    M Hauswald
    Department of Emergency Medicine, University of New Mexico, School of Medicine, Albuquerque 87131 5246, USA
    Acad Emerg Med 5:214-9. 1998
    To examine the effect of emergency immobilization on neurologic outcome of patients who have blunt traumatic spinal injuries.
  62. doi Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation
    Fei Zeng
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
    Lab Chip 8:653-6. 2008
    Techniques for stable, rapid and repeatable small-animal immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multi-cellular organisms...
  63. ncbi Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass
    Simon W Jones
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, The Medical School, University of Nottingham, Nottingham, NG7 2UH, UK
    FASEB J 18:1025-7. 2004
    ..Here, we induced skeletal muscle atrophy in healthy volunteers using two weeks of limb immobilization, and then stimulated the restoration of muscle mass with six weeks of supervised exercise rehabilitation...
  64. doi Muscle atrophy in immobilization and senescence in humans
    Andrew J Murton
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, The University of Nottingham, Nottingham, UK
    Curr Opin Neurol 22:500-5. 2009
    ..the mechanisms thought to be responsible for the determination of muscle mass during health, ageing and immobilization in humans have presented findings that have wide ranging implications...
  65. ncbi Time dependence of intrafraction patient motion assessed by repeat stereoscopic imaging
    Mischa S Hoogeman
    Department of Radiation Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 70:609-18. 2008
    ..The data can be used to optimize the intrafraction imaging frequency and consequent patient setup correction with an image guidance and tracking system, and to establish the required safety margins in the absence of such a system...
  66. ncbi Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization
    J Haapala
    Department of Surgery, University of Kuopio, Finland
    Int J Sports Med 21:76-81. 2000
    ..was to characterize the biomechanical and structural changes in canine knee cartilage after an initial 11-week immobilization and subsequent remobilization period of 50 weeks...
  67. ncbi Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA
    Ye Liu
    Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602, Singapore
    Angew Chem Int Ed Engl 44:4782-5. 2005
  68. doi Incidence of and risk factors for complications associated with halo-vest immobilization: a prospective, descriptive cohort study of 239 patients
    Joost J van Middendorp
    Department of Orthopaedics, University Medical Center Nijmegen, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Bone Joint Surg Am 91:71-9. 2009
    Since high rates of serious complications, such as death and pneumonia, during halo-vest immobilization have been reported, there has been a tendency of restraint with regard to the use of the halo vest...
  69. ncbi Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress
    Marco Cecchi
    The University of Michigan, Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuropharmacology 43:1139-47. 2002
    ..microinjected bilaterally into CeA of male Sprague-Dawley rats, and anxiety-like behavioral responses to acute immobilization stress were measured on the Social Interaction (SI) test and on the Elevated Plus-maze (EPMZ)...
  70. doi Interfractional set-up errors evaluation by daily electronic portal imaging of IMRT in head and neck cancer patients
    Berrin Pehlivan
    Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    Acta Oncol 48:440-5. 2009
    ..We aimed to evaluate whether a daily PI is worthwhile and we derived the Planning Target Volume (PTV) margins from the estimation of systematic and random errors...
  71. ncbi Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 28:103-10. 1997
    ..Male Wistar rats (6 weeks old) were exposed to immobilization stress for 8 h and their brains were processed for in situ hybridization histochemistry...
  72. doi Tracheal intubation with videolaryngoscopes in patients with cervical spine immobilization: a randomized trial of the Airway Scope and the GlideScope
    E H C Liu
    Department of Anaesthesia, National University Health System, National University of Singapore, Singapore
    Br J Anaesth 103:446-51. 2009
    ..We tested this hypothesis in a randomized comparison of the two videolaryngoscopes in patients whose cervical spines were immobilized...
  73. ncbi c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization
    M A Medeiros
    Departamento de Ciencias Fisiologicas, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Brasil
    Braz J Med Biol Res 36:1673-84. 2003
    ..Repeated immobilization protocols (6 days, 1 h/day and 13 days, 2 h/day) were used to reduce the effect of acute immobilization stress ..
  74. doi Low-volume resistance exercise attenuates the decline in strength and muscle mass associated with immobilization
    Bryan R Oates
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Muscle Nerve 42:539-46. 2010
    ..of low-volume resistance exercise (EX) for the attenuation of loss of muscle mass and strength during leg immobilization. Men (N = 5) and women (N = 12, age 24 ± 5 years, body mass index 25.4 ± 3...
  75. pmc Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
    Elisa I Glover
    Department of Kinesiology Exercise Metabolism Research Group, McMaster University, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
    J Physiol 586:6049-61. 2008
    ..We determined how 14 days of unilateral knee immobilization affected quadriceps myofibrillar protein synthesis (MPS) in young healthy subjects (10 men, 2 women, 21 +/- 1 ..
  76. ncbi Respiratory effects of spinal immobilization
    V Y Totten
    Department of Emergency Medicine, Catholic Medical Center, Jamaica, New York 11439, USA
    Prehosp Emerg Care 3:347-52. 1999
    To evaluate the effect of whole-body spinal immobilization on respiration.
  77. doi Immobilization impairs tactile perception and shrinks somatosensory cortical maps
    Silke Lissek
    Department of Neurology, BG Kliniken Bergmannsheil, Ruhr University, D 44780 Bochum, Germany
    Curr Biol 19:837-42. 2009
    ..Here, we report that a few weeks of hand and arm immobilization by cast wearing significantly reduced hand use and impaired tactile acuity, associated with reduced activation ..
  78. ncbi Should acute anterior dislocations of the shoulder be immobilized in external rotation? A cadaveric study
    Bruce S Miller
    Orthopaedic Research Laboratories, Division of Surgery, University of New South Wales, Prince of Wales Hospital, Sydney, Australia 2031
    J Shoulder Elbow Surg 13:589-92. 2004
    ..The mean contact force at 45 degrees of ER was 83.5 g. External rotation significantly increases the labrum-glenoid contact force and may influence the healing of a Bankart lesion...
  79. ncbi Comparison of perceived pain with different immobilization techniques
    D A Cross
    Department of Emergency Medicine, Scott and White Clinic and Memorial Hospital, Texas A and M University System Health Science Center, College of Medicine, Temple 76508, USA
    Prehosp Emerg Care 5:270-4. 2001
    ..The subjects were placed in one of three immobilization boards (hard spine board and two different vacuum splint models, identified as red and blue) for 60 minutes...
  80. ncbi Set-up verification using portal imaging; review of current clinical practice
    C W Hurkmans
    The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Radiother Oncol 58:105-20. 2001
    ..The reported set-up accuracy varies widely, depending on the treatment site, method of immobilization and institution...
  81. ncbi [Impact on reproducibility of the treatment position by improving immobilization device in image guided radiation therapy]
    Yuko Morita
    Miyakojima IGRT Clinic Medical Corporation Shinmeikai
    Nihon Hoshasen Gijutsu Gakkai Zasshi 68:254-9. 2012
    The immobilization device for treatment becomes important to obtain fixation and reproducibility of the treatment position...
  82. doi Interfraction and intrafraction performance of the Gamma Knife Extend system for patient positioning and immobilization
    David Schlesinger
    Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia 22908 0742, USA
    J Neurosurg 117:217-24. 2012
    ..The Extend system consists of a vacuum-monitored immobilization frame and a positioning measurement system used to determine the location of the patient's head within the ..
  83. ncbi Spinal immobilization in the field: clinical clearance criteria and implementation
    D G Hankins
    Department of Emergency Medicine, Mayo Clinic, Gold Cross Ambulance, Mayo One Helicopter, and Mayo Medical Communications, Rochester, Minnesota 55905, USA
    Prehosp Emerg Care 5:88-93. 2001
    Awareness of the health and financial repercussions of unnecessary immobilization has made cervical spinal immobilization controversial in out-of-hospital care...
  84. ncbi Maximizing comfort and minimizing ischemia: a comparison of four methods of spinal immobilization
    M Hauswald
    Department of Emergency Medicine, University of New Mexico School of Medicine, Albuquerque 87131 5246, USA
    Prehosp Emerg Care 4:250-2. 2000
    To determine which of four methods of spinal immobilization causes the least ischemic pain.
  85. doi Does cast immobilization contribute to posterior stability after posterior cruciate ligament reconstruction?
    Kyoung Ho Yoon
    Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea
    Arthroscopy 29:500-6. 2013
    The purpose of this study was to confirm the contribution of long leg cast immobilization to posterior stability after reconstruction of isolated posterior cruciate ligament (PCL) injuries.
  86. doi Estimating optimal shoulder immobilization postures following surgical repair of massive rotator cuff tears
    M Jackson
    Laboratoire de Simulation et Modélisation du Mouvement, Département de Kinésiologie, Universite de Montreal, Canada
    J Biomech 46:179-82. 2013
    Although shoulder immobilization is commonly prescribed following surgical repair of rotator cuff tears there is no consensus about the best shoulder immobilization postures...
  87. doi Na v1.4 and Na v1.5 are modulated differently during muscle immobilization and contractile phenotype conversion
    Fabrice Rannou
    Universite de Brest, Faculte de Medecine et des Sciences de la Sante, EA 4326, Laboratoire de Physiologie, Brest, France
    J Appl Physiol (1985) 111:495-507. 2011
    Muscle immobilization leads to modification in its fast/slow contractile phenotype...
  88. doi Mental practice maintains range of motion despite forearm immobilization: a pilot study in healthy persons
    Marie O Frenkel
    Department of Sport Psychology, Institute of Sport and Sport Science, University of Heidelberg, 69 115 Heidelberg, Germany
    J Rehabil Med 46:225-32. 2014
    To determine whether mental practice of wrist movements during forearm immobilization maintains range of motion.
  89. ncbi Effect of immobilization, immediate mobilization, and delayed mobilization on the resistance to digital flexion using a tendon injury model
    M N Halikis
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Hand Surg Am 22:464-72. 1997
    This study employed a tendon injury model in chickens to determine the effect of immobilization, immediate mobilization, and delayed mobilization on the energy required to fully flex the digit following surgical trauma to the tendon, as ..
  90. doi Chemical immobilization of chimpanzees (Pan troglodytes) using a combination of detomidine and ketamine
    Sanne Melis
    Department Of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan, Merelbeke, Belgium
    Vet Anaesth Analg 39:520-8. 2012
    To determine if a combination of detomidine and ketamine can be used for effective chemical immobilization of chimpanzees.
  91. ncbi The occipital and sacral pressures experienced by healthy volunteers under spinal immobilization: a trial of three surfaces
    Fintan Sheerin
    School of Nursing and Midwifery Studies, University of Dublin, Trinity College, Dublin, Ireland
    J Emerg Nurs 33:447-50. 2007
    ....
  92. ncbi [Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions]
    V G Podsevatkin
    Eksp Klin Farmakol 71:22-5. 2008
    Experiments on white mice under the model immobilization stress condition showed that a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, ..
  93. pmc Gene expression profile of the hippocampus of rats subjected to chronic immobilization stress
    Xiao Hong Li
    School of Pre clinical Medicine, Beijing University of Chinese Medicine, Beijing, China
    PLoS ONE 8:e57621. 2013
    ..This study systematically investigated the effect of chronic stress on the hippocampus and its damage mechanism at the whole genome level...
  94. pmc Effects of joint immobilization on standing balance
    Paulo B de Freitas
    Human Performance Lab, Department of Health, Nutrition and Exercise Sciences, University of Delaware, 541 S College Ave, Newark, DE 19716, USA
    Hum Mov Sci 28:515-28. 2009
    We investigated the effect of joint immobilization on the postural sway during quiet standing. We hypothesized that the center of pressure (COP), rambling, and trembling trajectories would be affected by joint immobilization...
  95. ncbi Immobilization induced fos expression in the medial and lateral hypothalamic areas: a limited response of hypocretin neurons
    Alexander Kiss
    Laboratory of Functional Neuromorphology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska str 3, 833 06 Bratislava, Slovakia
    Ideggyogy Sz 60:192-5. 2007
    ..examined in the rat hypothalamic neurons 3 h after a single (1 x120 min) or repeated (7x 120 min) immobilization (IMO) stress...
  96. ncbi Reversibility of immobilization-induced articular cartilage degeneration after remobilization in rat knee joints
    Akira Ando
    Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai, Japan
    Tohoku J Exp Med 224:77-85. 2011
    Joint immobilization is commonly used for the treatment of joint injuries, but it causes articular cartilage degeneration...
  97. ncbi Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo
    Jeffery J Maclean
    Department of Mechanical Engineering, University of Vermont, Burlington 05405 0156, USA
    Spine (Phila Pa 1976) 28:973-81. 2003
    An in vivo analysis of the intervertebral disc's cellular response to dynamic compression and immobilization was performed using a rat-tail model.
  98. doi Treatment algorithm for dens fractures: non-halo immobilization, anterior screw fixation, or posterior transarticular C1-C2 fixation
    Markus R Konieczny
    Department of Traumatology, General Hospital Klagenfurt, Academic Teaching Hospital of the University of Graz, Schlossmannstrasse 11, 40225 Dusseldorf, Germany
    J Bone Joint Surg Am 94:e144(1-6). 2012
    ..The appropriate treatment of dens fractures is unclear. We established a staged treatment protocol for dens fractures and conducted a prospective study to evaluate the outcome of treatment based on this protocol...
  99. doi Reversible immobilization of free-ranging snow leopards (panthera uncia) with a combination of medetomidine and tiletamine-zolazepam
    Orjan Johansson
    Grimsö Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, Riddarhyttan, Sweden
    J Wildl Dis 49:338-46. 2013
    ..there has been limited information available on safe capture methods, drug doses, and efficacy for effective immobilization of free-ranging snow leopards...
  100. ncbi Immobilization devices for intensity-modulated radiation therapy (IMRT)
    C B Saw
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha 68198 7521, USA
    Med Dosim 26:71-7. 2001
    ..Effective reduction in target positional inaccuracies can be achieved with the proper use of immobilization devices...
  101. doi A highly reproducible bolus immobilization technique for the treatment of scalp malignancies
    Steven H Lin
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Med Dosim 33:30-5. 2008
    ..We demonstrate a unique immobilization technique that maintains the bolus material on the aquaplast mesh adherent to the patient's scalp as well as ..

Research Grants75

  1. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..for calcium flux, secretory response and cytokine production will correlate functional responses with receptor immobilization, clustering and desensitization...
  2. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..postulated that demineralized bone matrix (DBM) contains something that "contributes slow release/immobilization characteristics to BMP", thus "reducing the amount of BMP needed" to stimulate osteogenesis...
  3. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2010
    ..Two of our recent technological innovations, ultrafast laser nanosurgery and microfluidics immobilization have made it feasible to study axonal regeneration in this genetically tractable model organism...
  4. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..normal and end-stage CKD patients, CKD rats with muscle wasting, and CKD rats with disuse atrophy induced by immobilization. Specific Aim 1. To evaluate the effect of uremia on GH mediated signal transduction in human skeletal muscle...
  5. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Immobilization of the ankle using a walking cast or boot is a common treatment to relieve pain...
  6. Ionic Liquid Gas Sensors for Detection of Flammable Gases In Workplace
    Xiangqun Zeng; Fiscal Year: 2010
    ..First, develop, characterize and optimize ionic liquid chemical interface immobilization in order to form robust, thin rigid films;Second, evaluate and validate the IL QCM sensor array for methane ..
  7. Mechanisms Involved in Age-Related Loss of Muscle Mass and Growth Response
    SUE CAROL BODINE; Fiscal Year: 2012
    ..studied the effects of aging on load-induced growth following a period of muscle wasting as occurs following immobilization and bed rest...
  8. Development of novel therapies for aging-induced skeletal muscle atrophy.
    SCOTT MATTHEW EBERT; Fiscal Year: 2013
    ..Although both compounds reduce skeletal muscle atrophy during fasting, limb immobilization and muscle denervation, their effects in aging-induced skeletal muscle atrophy are not yet known...
  9. Rigid-rod Peptides as Nanocarriers for Delivery of Cancer Drugs
    Katarzyna Slowinska; Fiscal Year: 2013
    ..conformation (3) it allows incorporation of drug targeting sequence or cell penetrating vector, (4) it allows immobilization of the prodrug within a collagen matrix ...
  10. Polarization and directed cell movements in engineered cellular environments
    Deborah E Leckband; Fiscal Year: 2010
    ..team possesses core competencies in microfabrication (Nuzzo), surface modification and protein immobilization (Leckband), biochemical/cell biological techniques (Wang), as well as expertise in cadherin biology (Leckband) ..
  11. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey D Esko; Fiscal Year: 2010
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  12. STRESS-OPIOID INTERACTION IN HIPPOCAMPUS
    Teresa A Milner; Fiscal Year: 2013
    ..electron microscopic immunocytochemistry, RT-PCR, in situ hybridization, in vitro slice electrophysiology and immobilization stress will test this hypothesis...
  13. Development of a 3D mammotomograph with novel techniques to overcome limitations
    Randolph L McKinley; Fiscal Year: 2010
    ..cancer patients for three purposes: (1) evaluation of a developed simple mechanism for uncompressed breast immobilization and biopsy capability;(2) evaluation of modified system on women of varying breast and body sizes to confirm ..
  14. Reducing wound bioburden and biofilm formation using a nanoscale wound surface en
    Jonathan F McAnulty; Fiscal Year: 2013
    ..nano-beads onto model wound surfaces (full and partial thickness skin wounds), using polyelectrolyte thin film immobilization methods, and evaluate their efficacy in preventing biofilm formation and biofilm dissolution in vivo;and in ..
  15. SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTION
    Hugh C Hemmings; Fiscal Year: 2013
    ..of anesthetic action is insufficient to explain how any anesthetic produces amnesia, unconsciousness or immobilization (with increasing doses), the cardinal features of general anesthesia...
  16. HIGH-THROUGHPUT IN VIVO SUBCELLULAR-RESOLUTION VERTEBRATE SCREENING PLATFORM
    Mehmet Fatih Yanik; Fiscal Year: 2013
    ..The proposed high-speed whole-animal manipulation, orientation, immobilization, imaging, microsurgery, and injection platform will enable a dramatic increase in the throughput and ..
  17. Discovery of genes that extend yeast lifespan: Aging in immobilized cell reactors
    RAPHAEL ROSENZWEIG; Fiscal Year: 2009
    ..Specific Aims of this investigation are threefold;we will: (1) Determine in wild-type yeast whether long-term immobilization alters chronological lifespan and global gene expression relative to aging planktonic cultures;(2) Establish, ..
  18. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..SCI require additional health care, which may be related to the degree of neurologic impairment or to chronic immobilization secondary to skeletal muscle paralysis...
  19. Mechanisms of Neuroinflammation after Fracture
    Wade S Kingery; Fiscal Year: 2013
    ..This proposal tests the hypothesis that fracture and immobilization can enhance sensory and sympathetic efferent signaling in skin keratinocytes and dorsal root ganglion (DRG) ..
  20. Structure-Function Studies &Molecular Interactions of Chemokines
    Tracy M Handel; Fiscal Year: 2013
    ..through homo- and hetero-oligomerization which may control other steps in cell migration in addition to immobilization on GAGs...
  21. FOXO signaling and skeletal muscle atrophy
    ANDREW ROBERT JUDGE; Fiscal Year: 2013
    ..atrophy is a widespread physiological phenomenon and significant health problem associated with muscle disuse (immobilization, bedrest, denervation) and various diseases (cancer, sepsis, AIDS, diabetes, chronic heart failure, chronic ..
  22. Cast Immobilization as a Model of Complex Regional Pain Syndrome
    David J Clark; Fiscal Year: 2011
    ..Surgery, trauma and immobilization are the most common causes of this syndrome...
  23. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott K Powers; Fiscal Year: 2012
    ..provide important information for broader topics such as skeletal muscle wasting due to prolonged bed rest, immobilization, and disease states...
  24. Effect of Stress on Glutamate Receptors and Signaling Proteins in the Basolateral
    EMIL CHRIS MULY; Fiscal Year: 2012
    ..We will use a rodent model of repeated, severe stress- repeated immobilization stress to study the effect of stress in the BLA...
  25. Tear-Resistant and Elastic Tissue Adhesive for Craniofacial Applications
    SILVIA D LUEBBEN; Fiscal Year: 2012
    ..cannot be used to repair deep dermal cuts or to close wounds that are under tensions unless sutures and/or immobilization are also used...
  26. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY G SAKHRANI; Fiscal Year: 2013
    ..The TriboGlide(R) technology is based on perfluoropolyether chemistry and gas plasma immobilization to create a lubricating coating that is resistant to migration and leads to less lubricant extraction into the ..
  27. Realtime Monitoring of Trace Amounts of Pesticides from Water Using Carbo
    ANNE M contact SCHWARTZ; Fiscal Year: 2010
    ..We propose to use carbon nanotube matrices as the active biosensor area for the effective immobilization of the pesticides through antibody based conjugation...
  28. The Molecular Pathogenesis of Skeletal Muscle Atrophy
    Kale S Bongers; Fiscal Year: 2013
    ..that Gadd45a and Cdkn1a mRNA levels are increased by various atrophy-promoting stresses, including aging, immobilization, fasting, and muscle denervation...
  29. Localized immobilization of ephrin-B2 for neurite guidance in 3D culture
    Michael J Moore; Fiscal Year: 2010
    ..we propose the following specific aims: Aim 1: Synthesize a photo-labile peptide hydrogel for localized immobilization of protein ligands...
  30. ECM and MMPs in Muscle Atrophy and Rehabilitation
    Hubert Kim; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Abstract Skeletal muscle atrophy is a common complication following immobilization, nerve injury, and musculoskeletal trauma such as tendon injuries...
  31. Composition, Structure, Dynamics and Function of C-Type Lectin Receptor Domains
    Nancy L Thompson; Fiscal Year: 2013
    ..First, the DC-SIGN molecules appear to be immobilized within the domains. Second, the origin of this immobilization is initiated in the extracellular carbohydrate recognition moiety rather than the membrane apposed ..
  32. Cytokine Regulation of Wound Induced Skin Regeneration
    AMANDA MARIE NELSON; Fiscal Year: 2013
    ..Defects in skin wound repair occur in patients with diabetes, pressure ulcers, prolonged immobilization and venous insufficiency...
  33. An Advanced Biosensor for Molecular Interaction Studies.
    SCOT RANDY WEINBERGER; Fiscal Year: 2013
    ..Numerous techniques, particularly the label-free methods, require surface immobilization of one of the interacting moieties putting the species in a non-native environment...
  34. Rotator Cuff Degeneration and Repair
    Stavros Thomopoulos; Fiscal Year: 2013
    ..In acute rotator cuff repairs, protective immobilization is beneficial to healing but complete removal of loading is detrimental to healing...
  35. Mechanisms of Integrin-Mediated Costimulation in T Cells
    Stephen C Bunnell; Fiscal Year: 2013
    ..assembly and translocation of SLP-76 microclusters? 2) How does costimulation depend on the VLA-4-dependent immobilization of microclusters? 3) How does cytoskeletal tension contribute to T cell costimulation by VLA-4? These studies ..
  36. Point-of-care system based on single polymer nanowires for real-time, AMI diagnos
    Minhee Yun; Fiscal Year: 2010
    ..This R21 application describes a plan to: (a) develop an effective method for monoclonal antibody immobilization on/into single polymer NWs (SPNWs);(b) optimize sensors by varying system and operational parameters, e.g...
  37. Musculoskeletal Response to Partial Weight Bearing
    Mary L Bouxsein; Fiscal Year: 2010
    ..for preventing musculoskeletal deterioration in situations of reduced mechanical loading, such as bed rest, immobilization, stroke, spinal cord injury and age-related reductions in physical activity...
  38. A Microfluidic Device for Label-free HIV Virion Count at Point of Care Settings
    Xuanhong Cheng; Fiscal Year: 2010
    ..The pressure build-up resulting from viral immobilization and pore blockage will be measured to calculate viral load in the original sample...
  39. Structure-Function of the Epithelial Sodium Channel (ENaC)
    WENDI MARJENE DAVID; Fiscal Year: 2013
    ..The influence of immobilization environment on the observed binding interactions will be determined...
  40. Cell-based screening and selection of cyclotide-based capture reagents for protei
    Julio A Camarero; Fiscal Year: 2013
    ..Of particular interest is the use of protein trans-splicing for the immobilization of these micro-proteins onto solid supports...
  41. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..molecules in response to allergic triggers, as well as by direct nerve stimulation and by acute immobilization stress...
  42. Phase 2 REAL-TIME MONITORING OF TRACE AMOUNTS OF PESTICIDES IN WATER AND FOOD USI
    ANNE M SCHWARTZ; Fiscal Year: 2013
    ..We propose to further develop the carbon nanotube matrices active biosensor area for effective immobilization of multiple pesticides, as well as preservation and manufacturing specifications of the sensors...
  43. Sensitive and multiplexed analysis of cancer biomarkers with QD barcodes
    Xiaohu Gao; Fiscal Year: 2012
    ..to stabilize the optical barcodes, and chemical conjugation approaches to optimize biomolecular probe immobilization. We will further carry out experiments to detect mutations on both DNA and RNA level as well as the profiles ..
  44. Novel Low Cost, High Throughput DNA Sequencing Platform
    James Schwaber; Fiscal Year: 2010
    ..e. >250 bp) while using flow cells and glass immobilization technologies to maximize the number of parallel reads (i.e. ~40 million)...
  45. Elimination of Mitochondrial Anchoring is Neuroprotective in Demyelination
    Shing Yan Chiu; Fiscal Year: 2013
    ..We interbred the Shiverer into a background lacking a mitochondrial immobilization protein (syntaphilin) that normally contributes to the increase in axonal mitochondrial content...
  46. Biomimetic Scaffold Anisotropy and Biomolecule Conjugation to Direct Tendon
    Brendan A Harley; Fiscal Year: 2013
    ..Aim 2 will test the hypothesis that temporally-organized biomolecule immobilization and release can enhance tenocyte bioactivity...
  47. Molecular Mechanisms of Skeletal Muscle Atrophy
    DANIEL KENNETH FOX; Fiscal Year: 2013
    ..and others found that Gadd45a mRNA is increased by a variety of stresses that cause muscle atrophy, including immobilization, denervation, fasting and aging...
  48. Microbubble Infused Hydrogels for Cartilage Tissue Engineering
    Clark T Hung; Fiscal Year: 2012
    ..generates micropores that are homogeneously distributed within the gels, while enabling the direct ab initio immobilization of cels within the gels...
  49. Local Sleep Regulation and Brain Plasticity
    Giulio Tononi; Fiscal Year: 2010
    ..test the converse prediction that procedures leading to a local depression of synaptic circuits, such as arm immobilization, should lead to a local decrease in SWA during subsequent sleep...
  50. Neural Probe for high spatial and temporal resolution detection of cocaine and su
    BRIAN GLENN JAMIESON; Fiscal Year: 2013
    ..of these probes by;1) improving functionalized probe fabrication by adjusting aptamer molecule modifications, immobilization technique, and electrical signal detection to achieve the best possible sensitivity and time response and 2) ..
  51. Precision Particle Fabrication-enabled Betamethasone-loaded Microspheres for Tran
    Milind Singh; Fiscal Year: 2012
    ..We will then determine the optimal microsphere immobilization strategy to enable RWM localization for a minimum of 14 days with minimal toxicity (Aim 2)...
  52. DNA Sequencing and Nanotechnology
    Nyoté J Oliver; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Protein immobilization has advanced significantly allowing for its application in a wide variety of areas including biosensors and nanotechnology...
  53. Mechanotransduction and the Regulation of Skeletal Muscle Mass
    Troy A Hornberger; Fiscal Year: 2013
    ..Furthermore, the outcomes could lead to the identification of targets for therapies that mimic the effects of mechanical stimuli and, in-turn, prevent atrophy during periods of disuse such as bedrest, immobilization and aging.
  54. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..Joint Immobilization Study: Atrophic articular cartilage containing chondrocytes with minimal synthetic activity will be produced ..
  55. REGULATION OF SKELETAL MUSCLE METABOLISM
    Leonard S Jefferson; Fiscal Year: 2013
    ..lead to loss of muscle mass including sedentary life styles, chronic bed rest, casting, limb suspension, and immobilization. Each of these inactivity-related conditions is thought to share a common feature, i.e...
  56. Molecular Signatures of Muscle Rehabilitation
    Krista Vandenborne; Fiscal Year: 2009
    ..Following cast-immobilization, subjects will be enrolled in a standardized 6-week rehabilitation program (3 sessions/week) focusing on ..
  57. Engineering Multi-Tissue Interfaces
    Paul H Krebsbach; Fiscal Year: 2012
    ..Three different immobilization models will be developed in this specific aim to gain maximal control of viral release through a dynamic ..
  58. Bioadhesive Membrane Construct for Hernia Repair
    NEIL WINTERBOTTOM; Fiscal Year: 2010
    ..Equally important, effective immobilization of the mesh against the abdominal wall is critical to hernia repair success...
  59. Neural probe for high spatial and temporal resolution detection of cocaine and GA
    BRIAN GLENN JAMIESON; Fiscal Year: 2013
    ..of these probes by;1) improving functionalized probe fabrication by adjusting aptamer molecule modifications, immobilization technique, and electrical signal detection to achieve the best possible sensitivity and time response, 2) ..
  60. Label-free and simultaneous detection of multiple bacterial pathogens and virulen
    HAO HOWARD XU; Fiscal Year: 2010
    ..The proposed experiments will also explore chemistry for probe immobilization (chip fabrication) and compare the SPRi results to data obtained with microarray methods used during probe ..
  61. The Interaction of Mechanical Load and Inflammation in Tendon-Bone Healing
    Scott A Rodeo; Fiscal Year: 2010
    ..relative tendon-bone interface motion will improve healing only if it is applied after an initial period of immobilization to allow resolution of acute inflammation and initiation of early healing...
  62. Integrin Regulation of IGF-1 Responsiveness in Bone During Mechanical Loading
    DANIEL DAVID BIKLE; Fiscal Year: 2012
    ..signaling in the skeletal response to load, results critical to our understanding of bone loss during skeletal immobilization from a variety of causes including paralysis and prolonged immobilization following injury or sickness...
  63. Microfabricated Neural Probe for the Rapid Detection of Multiple Neurochemicals I
    BRIAN GLENN JAMIESON; Fiscal Year: 2013
    ..of these probes by;1) improving functionalized probe fabrication by adjusting aptamer molecule modifications, immobilization technique, and electrical signal detection to achieve the best possible sensitivity and time response, 2) ..
  64. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..Acute psychological stress by immobilization triggered dura mast cell degranulation and resulted in cerebrospinal fluid (CSF) increase of rat mast cell ..
  65. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily ..
  66. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    ..Since the 1940s, in vivo toxic metal immobilization has involved the use of ethylenediamine-tetraacetate (EDTA) or dimercaptosuccinic acid (DMSA) following metal ..
  67. HYBRID ARTIFICIAL LIVER USING IMMOBILIZED HEPATOCYTES
    Ronald Tompkins; Fiscal Year: 1991
    The objective is the immobilization of hepatocytes for use in an artificial liver device. Hepatocytes will be isolated by established techniques using collagenase digestion and immobilized in a sodium alginate gel matrix...
  68. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2005
    ..It has been found that spastic muscles have increased type I (slow) fibers. Cerebral palsy, joint immobilization and tenotomy, three very different original conditions which cause muscle contracture, have a common ..
  69. IMMUNOBIOLOGICAL ROLE OF FERTILIZATION ANTIGEN (FA-1)
    RAJESH NAZ; Fiscal Year: 1993
    ..hamster ova and inhibited in vitro fertilization of mouse ova by murine sperm without causing agglutination or immobilization of sperm...
  70. Attenuation of denervation atrophy by nandrolone: molecular mechanisms
    Christopher Cardozo; Fiscal Year: 2009
    ..A significant impediment to rehabilitation is muscle atrophy as a consequence of paralysis, immobilization, medications, and chronic illness...
  71. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..produce a scanner capable of 10 second breast scanning, and the scanner development will also include a breast immobilization system (acrylic cylinders), a breast CT table, a fast reconstruction computer, and a computer workstation ..
  72. An Endothelial Progenitor Cell-Specific Nanofibrous Vascular Graft
    Lisa Fitzgerald; Fiscal Year: 2009
    ..synthesize and characterize in vitro a novel nanofibrous vascular graft material using our electrospinning and immobilization technology that would direct rapid adhesion and subsequent growth of circulating progenitor and more mature ..
  73. Rotator cuff tendon to bone insertion site healing
    Louis J Soslowsky; Fiscal Year: 2010
    ..b>Immobilization was found to result in better healing than either cage activity or exercise and the longer the period of ..
  74. IMMOBILIZED CELL FREE TRANSLATION SYSTEMS
    William Scouten; Fiscal Year: 1992
    ..in a way, an extension of the investigators laboratory's interest in solid phase biochemistry and biomolecule immobilization. The investigators will formulate their initial attempts to prepare an immobilized protein synthesis system ..
  75. Biomedical Polymers With Heparin-Binding End Groups
    Robert Ward; Fiscal Year: 2004
    Endpoint immobilization of heparin on the surface of polymeric biomaterials is a well-established method for improving thrombo-resistance...