human experimentation

Summary

Summary: The use of humans as investigational subjects.

Top Publications

  1. ncbi Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoes
    D F Verhage
    Departments of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 63:52-8. 2005
  2. ncbi Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
  3. ncbi Informed consent and collaborative research: perspectives from the developing world
    Adnan A Hyder
    Dev World Bioeth 6:33-40. 2006
  4. ncbi More than the money: a review of the literature examining healthy volunteer motivations
    Leanne Stunkel
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Contemp Clin Trials 32:342-52. 2011
  5. pmc Beyond informed consent
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    Bull World Health Organ 82:771-7. 2004
  6. pmc The history of biological warfare. Human experimentation, modern nightmares and lone madmen in the twentieth century
    Friedrich Frischknecht
    Friedrich Frischknecht is at the Malaria Biology and Genetics Unit, Department of Parasitology, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    EMBO Rep 4:S47-52. 2003
  7. ncbi Balancing justice and autonomy in clinical research with healthy volunteers
    N E Kass
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Berman Institute of Bioethics, Baltimore, Maryland, USA
    Clin Pharmacol Ther 82:219-27. 2007
  8. pmc Between universalism and relativism: a conceptual exploration of problems in formulating and applying international biomedical ethical guidelines
    G B Tangwa
    University of Yaounde, Cameroon
    J Med Ethics 30:63-7. 2004
  9. ncbi Therapeutic misconception in clinical research: frequency and risk factors
    Paul S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, USA
    IRB 26:1-8. 2004
  10. pmc Reasons for declining to enroll in a phase I and II HIV vaccine trial after randomization among eligible volunteers in Dar es Salaam, Tanzania
    Edith A M Tarimo
    Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e14619. 2011

Detail Information

Publications230 found, 100 shown here

  1. ncbi Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoes
    D F Verhage
    Departments of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 63:52-8. 2005
    ..The objective of this study was to evaluate infection rates and clinical safety of different protocols for human experimental malaria induced by Plasmodium falciparum-infected mosquitoes...
  2. ncbi Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
    ..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
  3. ncbi Informed consent and collaborative research: perspectives from the developing world
    Adnan A Hyder
    Dev World Bioeth 6:33-40. 2006
    ..This study, which is part of a larger project funded by the United States National Bioethics Advisory Commission, explores the opinions of developing country researchers regarding informed consent in collaborative research...
  4. ncbi More than the money: a review of the literature examining healthy volunteer motivations
    Leanne Stunkel
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Contemp Clin Trials 32:342-52. 2011
    ..This study summarized and analyzed existing empirical research on self-reported motivations of healthy volunteers participating in studies not intended to offer benefit from participation...
  5. pmc Beyond informed consent
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    Bull World Health Organ 82:771-7. 2004
    ..Further research is needed to examine the validity and user friendliness of innovations in information sharing procedures for obtaining consent in different cultural settings...
  6. pmc The history of biological warfare. Human experimentation, modern nightmares and lone madmen in the twentieth century
    Friedrich Frischknecht
    Friedrich Frischknecht is at the Malaria Biology and Genetics Unit, Department of Parasitology, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    EMBO Rep 4:S47-52. 2003
  7. ncbi Balancing justice and autonomy in clinical research with healthy volunteers
    N E Kass
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Berman Institute of Bioethics, Baltimore, Maryland, USA
    Clin Pharmacol Ther 82:219-27. 2007
    ..Other studies enrolling healthy volunteers often are simply looking for the most scientifically sound population for the study of normal human physiology...
  8. pmc Between universalism and relativism: a conceptual exploration of problems in formulating and applying international biomedical ethical guidelines
    G B Tangwa
    University of Yaounde, Cameroon
    J Med Ethics 30:63-7. 2004
    ....
  9. ncbi Therapeutic misconception in clinical research: frequency and risk factors
    Paul S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, USA
    IRB 26:1-8. 2004
  10. pmc Reasons for declining to enroll in a phase I and II HIV vaccine trial after randomization among eligible volunteers in Dar es Salaam, Tanzania
    Edith A M Tarimo
    Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e14619. 2011
    ..The reasons for such a decision are not well known. This article describes why individuals who were randomized in a phase I and II HIV vaccine trial in Dar es Salaam, Tanzania declined to be enrolled...
  11. ncbi Oversight of human participants research: identifying problems to evaluate reform proposals
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 141:282-91. 2004
    ....
  12. ncbi Establishing risk of human experimentation with drugs: lessons from TGN1412
    M J H Kenter
    Central Committee on Research Involving Human Subjects, The Hague, Netherlands
    Lancet 368:1387-91. 2006
  13. ncbi Why healthy subjects volunteer for phase I studies and how they perceive their participation?
    Luis Almeida
    Department of Research and Development, BIAL, A Av da Siderurgia Nacional, 4745 457, S Mamede do Coronado, Portugal
    Eur J Clin Pharmacol 63:1085-94. 2007
    ..To characterize the motivations and attitudes of healthy subjects who volunteer for phase I studies as well as their perception of the informed consent procedure and participation in the study...
  14. ncbi Moving beyond compliance: measuring ethical quality to enhance the oversight of human subjects research
    Holly A Taylor
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    IRB 29:9-14. 2007
  15. ncbi After Helsinki: unresolved issues in international research
    R Macklin
    Albert Einstein College of Medicine, Bronx, New York, USA
    Kennedy Inst Ethics J 11:17-36. 2001
    ..An analysis of these current controversies reveals reasons why they are not likely to be readily resolved, despite apparent agreement by opponents on overarching ethical principles...
  16. ncbi Is the concept of informed consent applicable to clinical research involving critically ill patients?
    John M Luce
    San Francisco General Hospital, CA, USA
    Crit Care Med 31:S153-60. 2003
    ..Stronger research oversight may be as important as informed consent in protecting patient welfare...
  17. ncbi Immunotherapy: bewitched, bothered, and bewildered no more
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
    Science 305:197-200. 2004
    ..We suggest steps to be taken to reinvigorate basic research in human subjects as part of the mainstream of science...
  18. ncbi Assessment of medical school institutional review board policies regarding compensation of subjects for research-related injury
    Michael K Paasche-Orlow
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Med 118:175-80. 2005
    ..We hypothesized that informed consent language at U.S. medical schools would be particularly complex and fall short of IOM goals, especially for projects without industry sponsorship...
  19. ncbi Ethics of medical research in developing countries: the role of international codes of conduct
    J L Hutton
    Department of Statistics, University of Newcastle, Newcastle upon Tyne, UK
    Stat Methods Med Res 9:185-206. 2000
    ..Statisticians share important responsibilities in maintaining ethical medical research in all countries...
  20. ncbi Human experimentation in developing countries: improving international practices by identifying vulnerable populations and allocating fair benefits
    Kristen Farrell
    University of Maryland School of Law, Baltimore, MD, USA
    J Health Care Law Policy 9:136-61. 2006
  21. ncbi Ethical aspects in placental perfusion studies: views of the researchers
    A Halkoaho
    University of Eastern Finland
    Placenta 32:511-5. 2011
    ..Thus, continuous effort for better research ethics is essential and requires research on research ethics...
  22. ncbi Views of midwives about ethical aspects of participation in placental perfusion studies
    Arja Halkoaho
    Department of Nursing Science, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland
    Midwifery 28:131-7. 2012
    ..Little is known regarding the role of the midwife in recruiting mothers to participate in scientific research...
  23. doi Clinical trials and healthy volunteers
    Pamela R Ferguson
    University of Dundee, Park Place, Dundee, UK
    Med Law Rev 16:23-51. 2008
  24. ncbi [Regulations, conflicts and ethics of medical research in developing countries]
    Marta Maciel Lyra Cabral
    Departmento de Imunologia, Fundacao Oswaldo Cruz, Recife, PE, Brasil
    Rev Saude Publica 40:521-7. 2006
    ..Therefore, it is necessary to minimize the risk of exploitation of developing countries populations. The present study provides an outlook of ethical protection for human research in developing countries...
  25. ncbi Conflicts of interest in research involving human beings
    Dirceu Greco
    School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    J Int Bioethique 19:143-54, 202-3. 2008
    ....
  26. ncbi Paying research subjects: an analysis of current policies
    Neal Dickert
    W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 136:368-73. 2002
    ..Few data are available on guidelines used by research organizations to make decisions about paying subjects...
  27. ncbi [Changes in the Declaration of Helsinki: economic fundamentalism, ethical imperialism and social control]
    V Garrafa
    , , , , DF, 70910-900, Brasil
    Cad Saude Publica 17:1489-96. 2001
    ....
  28. ncbi Informed consent for pediatric research: is it really possible?
    Eric Kodish
    J Pediatr 142:89-90. 2003
  29. ncbi Assessing benefits in clinical research: why diversity in benefit assessment can be risky
    Larry R Churchill
    Vanderbilt University, USA
    IRB 25:1-8. 2003
  30. ncbi [Ethics and medical research: principles, guidelines, and regulations]
    Euclides Ayres de Castilho
    Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de Sao Paulo, Av Dr Arnaldo 455, 01246 903 Sao Paulo, SP, Brazil
    Rev Soc Bras Med Trop 38:344-7. 2005
    ....
  31. ncbi Moral imperialism and multi-centric clinical trials in peripheral countries
    Volnei Garrafa
    Cátedra UNESCO de Bioética, Universidade de Brasilia, Brasilia, Brasil
    Cad Saude Publica 24:2219-26. 2008
    ....
  32. ncbi The age of neuroelectronics
    Adam Keiper
    The New Atlantis, USA
    New Atlantis 11:4-41. 2006
  33. ncbi Experimental malaria in human volunteers: ethical aspects
    H K A Visser
    Neth J Med 63:41-2. 2005
  34. ncbi Justice and the human development approach to international research
    Alex John London
    Carnegie Mellon University, USA
    Hastings Cent Rep 35:24-37. 2005
  35. ncbi Money for research participation: does in jeopardize informed consent?
    C Grady
    National Institutes of Health, USA
    Am J Bioeth 1:40-4. 2001
    ..An amount of money that is not excessive and is calculated on the basis of time or contribution may, rather than constitute an undue inducement, be an indication of respect for the time and contribution that research subjects make...
  36. pmc The role of community advisory boards: involving communities in the informed consent process
    R P Strauss
    Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
    Am J Public Health 91:1938-43. 2001
    ..These activities could help reduce the number of individual informed consent lapses, benefiting study participants and the scientific integrity of the research in question...
  37. pmc Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults
    Isabel Leroux-Roels
    Center for Vaccinology, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Clin Vaccine Immunol 17:1763-71. 2010
    ..In conclusion, Mtb72F/AS02(A) is clinically well tolerated and is highly immunogenic in TB-naïve adults. The 10- and 40-μg Mtb72F/AS02(A) vaccines show comparable safety and immunogenicity profiles...
  38. ncbi Evaluating the quality of informed consent
    Jeremy Sugarman
    Phoebe R Berman Bioethics Institute, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Clin Trials 2:34-41. 2005
    ..Having such means will be important to monitoring consent and testing potential improvements in the consent process...
  39. ncbi Early stage-specific immune responses in primary experimental human hookworm infection
    Stefan M Geiger
    Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Avenida Augusto de Lima 1715, CEP 30190 002, Belo Horizonte MG, Brazil
    Microbes Infect 10:1524-35. 2008
    ..During reinfection studies in endemic areas, such distinct cytokine and chemokine profiles might be additional markers to better classify egg-negative patients...
  40. pmc An assessment of early diagnosis and treatment of malaria by village health volunteers in the Lao PDR
    Viengvaly Phommanivong
    Institut de Francophonie pour Médecine Tropicale, Vientiane, BP 9519, Lao PDR
    Malar J 9:347. 2010
    ..Early diagnosis and treatment (EDAT) is crucial to reducing the burden of malaria in low-income countries. In the Lao PDR, this strategy was introduced in 2004-2005 and an assessment was performed at the community level in January 2007...
  41. pmc Principal investigator views of the IRB system
    Simon N Whitney
    Department of Family, Community Medicine, Houston Center for Education, Research on Therapeutics, Baylor College of Medicine, Houston, TX 77098 3926, USA
    Int J Med Sci 5:68-72. 2008
    ..Significant concern was expressed about the cost, inefficiency, and irrationality of IRB review. The IRB system works well for some researchers, but our results indicate that other investigators feel the costs outweigh the benefits...
  42. ncbi Obtaining voluntary consent for research in desperately ill patients
    Charles L Bosk
    Department of Sociology, Center for Bioethics, Philadelphia, Pennsylvania, USA
    Med Care 40:V64-8. 2002
    ..This finding bypasses the careful weighing of risks and benefits that the model of informed consent is based upon. This paper explores how the requirements of candor need to be balanced with those of kindness...
  43. pmc Ethics review for sale? Conflict of interest and commercial research review boards
    T Lemmens
    Faculty of Law, University of Toronto, 78 Queen s Park, Toronto, Ontario, Canada M5S 2C5
    Milbank Q 78:547-84, iii-iv. 2000
    ..The structure of private review tends to breach a core principle of administrative law and procedural justice. Reform of the research review system will reinforce public trust in the process...
  44. ncbi International Genetic Epidemiology Society: commentary on Darkness in El Dorado by Patrick Tierney
    M P Baur
    Department of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Genet Epidemiol 21:81-104. 2001
    ..Ethical issues about scientific research in primitive populations deserve serious and wide discussion, but the IGES condemns the gross misrepresentation of the facts and demonization of the principal characters in this book...
  45. ncbi Ethics. Protecting communities in biomedical research
    C Weijer
    Department of Bioethics, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada
    Science 289:1142-4. 2000
    Although for the last 50 years, ethicists dealing with human experimentation have focused primarily on the need to protect individual research subjects and vulnerable groups, biomedical research, especially in genetics, now requires the ..
  46. ncbi Principles of early stopping of randomized trials for efficacy: a critique of equipoise and an alternative nonexploitation ethical framework
    David Buchanan
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 15:161-78. 2005
    ....
  47. pmc Ethics in international health research: a perspective from the developing world
    Zulfiqar Ahmed Bhutta
    Department of Paediatrics, The Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 80:114-20. 2002
    ..Only through such proactive measures can we address the emerging ethical dilemmas and challenges that globalization and the genomics revolution will bring in their wake...
  48. ncbi Research without consent: current status, 2003
    Michelle H Biros
    Department of Emergency Medicine, Hennepin County Medical Center and the University of Minnesota School of Medicine, 701 Park Avenue South, Minneapolis, MN 55415, USA
    Ann Emerg Med 42:550-64. 2003
    ....
  49. ncbi Understanding of informed consent in a low-income setting: three case studies from the Kenyan Coast
    C S Molyneux
    Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    Soc Sci Med 59:2547-59. 2004
    ..These themes and emerging recommendations are expected to be relevant to, and would benefit from, experiences and insights of researchers working elsewhere...
  50. ncbi The old faith and the new science: the Nuremberg Code and human experimentation ethics in Britain, 1946-73
    Jenny Hazelgrove
    School of Nursing, University of Nottingham, UK
    Soc Hist Med 15:109-35. 2002
    ..In a similar move, their predecessors had helped to negotiate the Nuremberg Code in anticipation of public criticism of experimentation arising from the Nuremberg Medical Trial...
  51. ncbi The dysregulation of human subjects research
    Norman Fost
    JAMA 298:2196-8. 2007
  52. ncbi The therapeutic misconception: problems and solutions
    Charles W Lidz
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Med Care 40:V55-63. 2002
    ..The therapeutic misconception is a serious problem for informed consent in clinical research...
  53. ncbi Reconstructing exposures from the UK chemical warfare agent human research programme
    Tj Keegan
    Department of Public Health, University of Oxford, Oxford OX7 3LF, UK
    Ann Occup Hyg 51:441-50. 2007
    ..The resulting cohort study has the potential to provide information which will assist in understanding the long-term health impact of chemical warfare agent exposure on these veterans...
  54. ncbi Exposures recorded for participants in the UK Chemical Warfare Agent Human Research Programme, 1941-1989
    T J Keegan
    Department of Public Health, University of Oxford, OX3 7LF, UK
    Ann Occup Hyg 53:83-97. 2009
    ..The study is part of a programme of epidemiological research initiated in response to service veterans' concerns about possible long-term health effects of their participation...
  55. pmc Human hallucinogen research: guidelines for safety
    Mw Johnson
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 22:603-20. 2008
    ..Incautious research may jeopardize participant safety and future research. However, carefully conducted research may inform the treatment of psychiatric disorders, and may lead to advances in basic science...
  56. pmc Identification of Haemophilus ducreyi genes expressed during human infection
    Margaret E Bauer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Microbiology 154:1152-60. 2008
    ..We identified three genes, lspA1, lspA2 and tadA, known to be required for virulence in humans. This is the first study to broadly define transcripts expressed by H. ducreyi in humans...
  57. pmc Human testing of pesticides: ethical and scientific considerations
    Alan H Lockwood
    Center for PET 115P, VA Western NY Healthcare System, 3495 Bailey Ave, Buffalo, NY 14215, USA
    Am J Public Health 94:1908-16. 2004
    ..An EPA committee that is free from political and financial conflicts of interest should review this practice...
  58. pmc Pesticide testing in humans: ethics and public policy
    Christopher Oleskey
    Center for Children s Health and the Environment, Box 1043, Mount Sinai School of Medicine, One Gustav L Levy Place, New York, NY 10029, USA
    Environ Health Perspect 112:914-9. 2004
    ..Participants also strongly encouraged active biomonitoring of every pesticide currently in use to track human exposure, particularly in vulnerable populations, and to assess adverse effects on health...
  59. ncbi Recommendations for informed consent forms for critical care clinical trials
    Henry J Silverman
    University of Maryland School of Medicine, Baltimore, MD, USA
    Crit Care Med 33:867-82. 2005
    ..Many subjects enrolled in research studies have a limited understanding of the research to which they consented...
  60. ncbi Is the argument from marginal cases obtuse?
    Daniel A Dombrowski
    Seattle University, Seattle, WA 98122, USA
    J Appl Philos 23:223-32. 2006
    ..The purpose of the present article is to argue that, despite Anderson's and Diamond's nuanced and perceptive treatments of the argument from marginal cases, this argument is not obtuse in either sense of the term...
  61. ncbi The role of institutional review boards in protecting human subjects: are we really ready to fix a broken system?
    Hazel Glenn Beh
    William S Richardson School of Law, University of Hawaii, USA
    Law Psychol Rev 26:1-47. 2002
  62. ncbi Challenges of ethical research in resource-poor settings
    B M Dickens
    Faculty of Law, University of Toronto, Toronto, Ontario, Canada
    Int J Gynaecol Obstet 80:79-86. 2003
    ..The structure and functions of research ethics review committees present difficult challenges, but they may be mitigated by enlightened international collaboration...
  63. ncbi Research ethics and law of healthcare system quality improvement: the conflict of cost containment and quality
    W Andrew Kofke
    Department of Anesthesia, University of Pennsylvania, Philadelphia 19104 4283, USA
    Crit Care Med 31:S143-52. 2003
    ..The ethical and legal foundations exist to support the systematic practice of informing patients of their participation in some types of QI procedures...
  64. ncbi Vulnerability to influence: a two-way street
    Gail E Henderson
    University of North Carolina School of Medicine, USA
    Am J Bioeth 4:50-2; discussion W32. 2004
  65. ncbi Research on the socio-ethical impact of biomarker use and the communication processes in ECNIS NoE and NewGeneris IP
    Birgit Dumez
    Center for Human Genetics, Department of Medicine, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Hyg Environ Health 210:263-5. 2007
    ..A harmonized socio-ethical and legal approach not only increases the possibilities for comparison between data generated but may also allow for more equality in the protection of the rights of each citizen of the European Union...
  66. pmc Human subjects issues and IRB review in practice-based research
    Leslie E Wolf
    University of California, San Francisco, San Francisco, California 94143 0903, USA
    Ann Fam Med 3:S30-7. 2005
    ..This article explores the challenges that practice-based research networks (PBRNs) face with respect to the regulatory requirements for institutional review board (IRB) review and the protection of human subjects in research...
  67. ncbi Ethics of innovative surgery: US surgeons' definitions, knowledge, and attitudes
    Angelique M Reitsma
    Center for Biomedical Ethics, University of Virginia, PO Box 800758, Charlottesville, VA 22908 0758, USA
    J Am Coll Surg 200:103-10. 2005
    ..Surgeons were also invited to self-report knowledge about current federal regulations guiding human subject research and rules for informed consent for and IRB review of clinical research...
  68. pmc Human experimentation: a rule gone awry?
    Adrian Burton
    Environ Health Perspect 114:A360-2. 2006
  69. pmc Bench-to-bedside review: human subjects research--are more standards needed?
    David T Huang
    CRISMA Laboratory, Department of Critical Care Medicine, Department of Emergency Medicine, University of Pittsburgh, 641 Scaife Hall, Pittsburgh, PA 15261, USA
    Crit Care 10:244. 2006
    ..We conclude that what is needed are not more standards per se, but rather refinement and uniformity of current standards, and their interpretation and application both to protect human subjects and to advance medicine...
  70. pmc Ethical review of health research: a perspective from developing country researchers
    A A Hyder
    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    J Med Ethics 30:68-72. 2004
    ....
  71. ncbi Rationalizing risk assessment in human subject research
    Carl H Coleman
    Health Law and Policy Program, Seton Hall Law School, USA
    Ariz Law Rev 46:1-51. 2004
  72. ncbi Are the rules for research with subjects with dementia changing?: views from the field
    Carol B Stocking
    Section of Geriatrics, MacLean Center for Clinical Medical Ethics, Department of Medicine, University of Chicago, IL 60637, USA
    Neurology 61:1649-51. 2003
    ..The real tradeoff between protection and difficulty in conducting research on devastating illnesses needs to be confronted when new regulations in this area are debated...
  73. ncbi Human experimentation with Neisseria gonorrhoeae: progress and goals
    M S Cohen
    Department of Medicine, University of North Carolina at Chapel Hill 27599 7030, USA
    J Infect Dis 179:S375-9. 1999
    ..The experimental model has proven to be an efficient means of studying gonococcal infection and focusing vaccine development. In addition, this model should allow vaccines to be tested quickly and efficiently...
  74. ncbi Regional ethics organizations for protection of human research participants
    Anne Wood
    School of Law, University of California, Berkeley, Berkeley, California 94720 7200, USA
    Nat Med 10:1283-8. 2004
  75. pmc Ethics review procedures for research in developing countries: a basic presumption of guilt
    Robert H Gilman
    Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    CMAJ 171:248-9. 2004
  76. pmc Should society allow research ethics boards to be run as for-profit enterprises?
    Ezekiel J Emanuel
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States
    PLoS Med 3:e309. 2006
    ..Critics argue that for-profit IRBs have a conflict of interest because they generate their income from clients who have a direct financial interest in obtaining approval...
  77. ncbi What is a "minor" increase over minimal risk?
    David Wendler
    Department of Clinical Bioethics, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA
    J Pediatr 147:575-8. 2005
  78. ncbi Educating researchers: ethics and the protection of human research participants
    Julie Rothstein Rosenbaum
    Yale University School of Medicine, New Haven, CT, USA
    Crit Care Med 31:S161-6. 2003
    ....
  79. ncbi The case of Chester M. Southam: research ethics and the limits of professional responsibility
    Beth Aviva Preminger
    Cornell University Joan and Sanford I Weill Medical College, USA
    Pharos Alpha Omega Alpha Honor Med Soc 65:4-9. 2002
  80. ncbi Research firm changes subject notification procedure after complaint by potential subject
    Dennis M Maloney
    The Deem Corporation, P O Box 44069, Omaha, NE 68144, USA
    Hum Res Rep 17:6-7. 2002
  81. ncbi Undue inducement: the only objection to payment?
    Ari VanderWalde
    UCLA, USA
    Am J Bioeth 5:25-7. 2005
  82. ncbi A quartet of criticisms
    Harold Y Vanderpool
    University of Texas Medical Branch, USA
    Am J Bioeth 5:16-9. 2005
  83. ncbi Undue inducement: nonsense on stilts?
    Ezekiel J Emanuel
    National Institutes of Health, USA
    Am J Bioeth 5:9-13; discussion W8-11, W17. 2005
  84. ncbi Institutional review boards and the privacy of human research subjects
    Dennis M Maloney
    The Deem Corporation, P O Box 44069, Omaha, NE 68144, USA
    Hum Res Rep 17:1-2. 2002
  85. ncbi The current situation regarding the establishment of national ethical guidelines for biomedical research in Thailand and its neighboring countries
    Somei Kojima
    Asian Center of International Parasite Control, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 36:728-32. 2005
    ..This indicates that further efforts should be made to establish research guidelines and/or principles dealing with the human genome...
  86. ncbi Clinical trials face heightened scrutiny as science and commerce appear to merge
    Alvin J Lorman
    Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, USA
    J Biolaw Bus 4:23-32. 2001
    ..The risk of increased government involvement includes criminal prosecution of physicians for failing to follow the rules, as an innovative case in California demonstrates...
  87. ncbi Beginning anew: same principles, different direction for research ethics
    Mary Simmerling
    University of Chicago, USA
    Am J Bioeth 5:44-6; author reply W15-8. 2005
  88. ncbi Research versus innovation: real differences
    Haavi Morreim
    University of Tennessee Health Science Center, USA
    Am J Bioeth 5:42-3; author reply W15-8. 2005
  89. ncbi Does research ethics rest on a mistake? The common good, reasonable risk and social justice
    Alex John London
    Carnegie Mellon University
    Am J Bioeth 5:37-9; author reply W15-8. 2005
  90. ncbi Does research ethics rest on a mistake?
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, USA
    Am J Bioeth 5:34-6; author reply W15-8. 2005
  91. ncbi How not to rethink research ethics
    Tom L Beauchamp
    Georgetown University, USA
    Am J Bioeth 5:31-3; author reply W15-8. 2005
  92. ncbi Some questionable premises about research ethics
    Ruth Macklin
    Albert Einstein College of Medicine, USA
    Am J Bioeth 5:29-31; author reply W15-8. 2005
  93. ncbi Rethinking research ethics
    Rosamond Rhodes
    Mount Sinai School of Medicine
    Am J Bioeth 5:7-28. 2005
    ..These include: the primacy of informed consent, the protection of the vulnerable, the substitution of beneficence for research's social purpose, and the introduction of an untenable distinction between innovation and research...
  94. ncbi Reflections on 'Rethinking research ethics'
    Robert J Levine
    Am J Bioeth 5:1-3; author reply W15-8. 2005
  95. ncbi Response to Athula Sumathipala and Sisira Siribaddana, "Revisiting 'freely given informed consent' in relation to the developing world: the role of an Ombudsman" (AJOB 4:3)
    Bob Simpson
    Am J Bioeth 5:W24-6. 2005
  96. ncbi The limitations of "vulnerability" as a protection for human research participants
    Carol Levine
    United Hospital Fund
    Am J Bioeth 4:44-9. 2004
    ..Certain individuals require ongoing protections of the kind already established in law and regulation, but attention must also be focused on characteristics of the research protocol and environment that present ethical challenges...
  97. ncbi A plea for pragmatism in clinical research ethics
    David H Brendel
    Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Am J Bioeth 8:24-31. 2008
    ....
  98. ncbi Part I: what is the requirement for data sharing?
    Virginia A de Wolf
    IRB 27:12-6. 2005
  99. pmc Strangers at the benchside: research ethics consultation
    Mildred K Cho
    Stanford Center for Biomedical Ethics, Center for Integration of Research on Geneticsand Ethics, Palo Alto, CA 94304, USA
    Am J Bioeth 8:4-13. 2008
    ..We make preliminary recommendations for the structure and process of research ethics consultation, based on our initial experiences in a pilot program...
  100. ncbi [Clinical trials in developing countries: who should define ethics?]
    F Béréterbide
    Faculte de Medecine, Département de recherche éthique, Universite Paris Sud XI, France
    Bull Soc Pathol Exot 101:102-5. 2008
    ....

Research Grants77

  1. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..We will also develop a RASV using S. Typhi as vector to prevent transmission and infection by Mycobacterium tuberculosis. ..
  2. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..A convenient laboratory model for these diseases is needed if the use of pharmacoperones is to translate to human well-being, since US law requires animal testing prior to normal human volunteers. ..
  3. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ..humans directly;however, many experiments require interventions or assessments that are too invasive for human experimentation. For such studies, examination of nonhuman primates (NHPs) provides an attractive alternative...
  4. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..IV dose range-finding and 2 week repeat-dose toxicology studies in rats and dogs, with associated toxicokinetic determinations. ..
  5. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2012
    ....
  6. Inhibition of Carboxylesterase Metabolism by Ethanol
    Robert B Parker; Fiscal Year: 2011
    ..Understanding this interaction is a necessary component for the safe and effective use of drugs metabolized by carboxylesterases. ! ..
  7. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven L Spitalnik; Fiscal Year: 2012
    ....
  8. Syk blockade in bullous skin diseases
    Uma Sinha; Fiscal Year: 2012
    ..In this Phase I program we will provide proof-of-concept for Syk inhibitors in BP using both animal models and relevant ex vivo human biospecimens. ..
  9. The Role of Protein Kinase D in Epidermal Tumorigenesis
    Wendy B Bollag; Fiscal Year: 2013
    ..Evidence concerning the role of PKD in the keratinocyte response to UVB may be important for predicting possible sun sensitivity in patients undergoing systemic chemotherapy with PKD inhibitors. ..
  10. MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM IN MAN
    Lawrence J Mandarino; Fiscal Year: 2013
    ..Protein targets for this aim will be prioritized based on the potential role of the protein in insulin resistance or mitochondrial function as well as dysregulation of its acetylation state in insulin resistant muscle. ..
  11. Detection of Brown Adipose Tissue Using Contrast Ultrasound
    Marielle Scherrer-Crosbie; Fiscal Year: 2012
    ..If the proposal is successful, CEU may be a non irradiating, widely available technique to detect BAT and monitor potential therapies that increase functional BAT. ..
  12. Chronic DTH and IFN-gamma in Human Graft Arteriosclerosis
    Jordan S Pober; Fiscal Year: 2010
    ....
  13. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..
  14. Imaging Cytolytic T Cells in Cancer Patients Using PET Reporter Genes/Reporter Pr
    Sanjiv S Gambhir; Fiscal Year: 2012
    ..Here, we propose non-invasive imaging of therapeutic immune cells that will be infused into patients with glioma brain tumors and have been shown to kill glioma brain tumor cells. ..
  15. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..This therapeutic approach will reduce killed in action (KIA) rate, increased life saving capability for the medic, and reduce need for surgery and transfusion. [unreadable] [unreadable] [unreadable]..
  16. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark A Geyer; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Despite hundreds of years of human experimentation and recent increases in the use of hallucinogens either as religious sacraments or as "Club Drugs" in ..
  17. PATHOGENESIS OF HAEMOPHILUS DUCREYI INFECTIONS
    Stanley M Spinola; Fiscal Year: 2013
    ..Chancroid can be treated with only three types of antibiotics. The genes controlled by the stress response systems may prove to be targets of vaccines or alternative treatments for H. ducreyi infection. ..
  18. Mechanisms of Altered Skin Re-Epithelialization in Aging
    Laure Rittie; Fiscal Year: 2013
    ....
  19. Influence of Gonadal Hormones on Fear Extinction
    Mohammed R Milad; Fiscal Year: 2010
    ..This proposal will also examine the influence of progesterone administration on boosting the brain's signal for safety. Findings from this proposal may help the development of sex-specific treatments for anxiety disorders...
  20. Genome-wide genetic variation in the human immune response to influenza vaccines
    LUIS MIGUEL FRANCO; Fiscal Year: 2013
    ..The results of this research will help in the development of better vaccines and allow healthcare practitioners to use a more personalized approach to vaccination. ..
  21. Training and research application for c-spine ultrasound of an aging population.
    DANIEL BUCKLAND; Fiscal Year: 2013
    ....
  22. The Impact of Tobacco Exposure on the Lungs Innate Defense System
    Robert Tarran; Fiscal Year: 2013
    ..Such knowledge may help dispel the myth that new tobacco products represent a safer alternative to cigarettes. ..
  23. Thalamic Visual Prosthesis
    John S Pezaris; Fiscal Year: 2013
    ..As proposed here, an important step in making a device like that is to understand how complicated it needs to be in order to be useful and to test a prototype in an animal model. ..
  24. Optimization of HIV vaccines for the induction of cross-reactive antibodies
    Shan Lu; Fiscal Year: 2013
    ..RELEVANCE: To optimize the next generation polyvalent Env HIV vaccine formulations using the multi-gene, polyvalent DNA prime - protein boost technology platform. ..
  25. An ACE Inhibitor as a Treatment for Methamphetamine Dependence
    THOMAS FREDERICK NEWTON; Fiscal Year: 2012
    ..A separate human laboratory study will examine the dose-dependent effects of perindopril on MA- induced craving, though these participants will not take part in the clinical trial. ..
  26. Interactive MR Image Guided Intervention (iMR-IGI) for Breast Applications
    MICHAEL ROY ZINN; Fiscal Year: 2012
    ..In time, additional benefits could include less aggressive recommendations for MRI detected lesions and, more importantly, a paradigm shift for breast cancer detection, diagnosis and treatment in general. ..
  27. Clinical Development of 4-Cl-KYN to Treat Pain
    RALPH SNODGRASS; Fiscal Year: 2010
    ..Positive results from this study will serve as a basis for further development of AV-101 in Phase II trials for treatment of neuropathic pain. ..
  28. LC-MS Analysis of DNA Adducts of Aromatic Amines: Relationship to Bladder Cancer
    Paul Vouros; Fiscal Year: 2013
    ..abstract_text> ..
  29. Free-Breathing Perfusion MRI of the Abdomen with Predictive Motion Correction
    H Michael Gach; Fiscal Year: 2013
    ..The technique may be further developed for other anatomical regions of interest or applications where physiological motion impedes accurate diagnosis or therapy (e.g., radiotherapy). ..
  30. An interdisciplinary approach to elucidate mechanisms of muscle lipotoxicity
    GREGORY PAUL ROTH; Fiscal Year: 2011
    ..abstract_text> ..
  31. Endothelial Progenitor Cells in Diabetes and Renal Failure
    Karen A Lapidos; Fiscal Year: 2010
    ..In the current investigation, EPCs from patients with diabetes and kidney failure will be examined to determine their suitability for such cell based-therapies. ..
  32. Licit Abused Drugs
    Roland R Griffiths; Fiscal Year: 2013
    ..The project will provide information about pharmacological, behavioral and genetic determinants of vulnerability to substance abuse, with important substance abuse prevention, treatment, and public education implications. ..
  33. Genetically Attenuated Malaria Attenuated Whole Parasite Sporozoite Vaccine
    STEPHEN LEV HOFFMAN; Fiscal Year: 2012
    ..The PfSPZ Vaccine is attenuated (weakened) by irradiation of each vaccine lot. This research aims to eliminate the need for irradiation in manufacturing a PfSPZ vaccine, by creating parasites that are attenuated by gene removal. ..
  34. Mechanical Airway Support Device to Treat Obstructive Sleep Disordered Breathing
    Philip M Wong; Fiscal Year: 2013
    ..The investigative team, with demonstrated expertise in respiratory biomedical innovation, sleep medicine, and commercialization, is ideally positioned to execute this project successfully. ..
  35. Neuropharmacology of Tramadol: Clinical Efficacy and Abuse Potential
    WILLIAM WALTON STOOPS; Fiscal Year: 2010
    ..Developing analgesics with reduced abuse potential may reduce the prevalence of prescription opioid misuse and subsequent opioid use disorders. ..
  36. Merging Diffuse Optical Tomography with EEG, MEG and MRI for Neurovascular Exams
    Solomon Gilbert Diamond; Fiscal Year: 2010
    ..Research on the neurovascular relationship will ultimately have long-term benefits to understanding the aging brain and diagnosing neurological diseases. ..
  37. Preparation and Distribution of Adult Stem Cells
    DARWIN JOHNSON PROCKOP; Fiscal Year: 2013
    ..We will provide assistance from a collaborating expert in bioinformatics in evaluating the data. ..
  38. RESEARCH PROJECT 1
    James L Howard; Fiscal Year: 2011
    ..Information from all the studies will be used for prioritization of compounds to be submitted for toxicological evaluation by NIDA and final selection of a back-up compound. ..
  39. The genetic basis of impulsive behavior in humans
    Harriet de Wit; Fiscal Year: 2013
    ..The study is innovative because it combines rigorous behavioral analysis with multi-level genetic analysis. ..
  40. Lysolipid Signaling in Cardiovascular Disease
    Susan S Smyth; Fiscal Year: 2013
    ..Completion of these studies promises to provide valuable insight into regulation of platelet function and may have exciting implications for the development of novel anti-thrombotic strategies that target LPA signaling. ..
  41. Induction of Immunity in Human Genital Tract: Effect of Intranasal Immunization
    Zina Moldoveanu; Fiscal Year: 2010
    ..The results obtained will be important for the design of immunization strategies to prevent infections with agents of sexually transmitted diseases. ..
  42. Chloroquine Sensitive Plasmodium falciparum for MultiValent Vaccine &Challenge
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ....
  43. Clinical Pharmacology/Mechanisms of Action of Emerging Abused Drugs (Club Drugs)
    Roland R Griffiths; Fiscal Year: 2013
    ....
  44. Attenuated Live and Recombinant Yersinia pestis Vaccines
    Roy Curtiss; Fiscal Year: 2013
    ..We will provide research support during the proposed clinical trials. ..
  45. Systems genetic analysis of methamphetamine's motivational effects in a mouse AIL
    Abraham A Palmer; Fiscal Year: 2013
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  46. The endothelium and resistance to rickettsial infection
    Gustavo Valbuena; Fiscal Year: 2012
    ..The innovation of our research lays in bridging the gap between animal and human experimentation by implementing novel in vivo physiological experimental systems of the human endothelium and our ability ..
  47. Heat Effect on Generic Transdermal Drug Delivery Systems
    Audra L Stinchcomb; Fiscal Year: 2013
    ..Future years of this project could include examination of the heat effect on additional drug patches, on special patient populations, and on skin with compromised barrier. ..
  48. Source-Filter Interaction in Speech
    Ingo R Titze; Fiscal Year: 2013
    ..Human volunteers and computer simulation will be used in a structured way to quantify and explain the nature of SFI. ..
  49. An NMDA Glycine Site Antagonist for the Treatment of Major Depressive Disorder
    Robert Schwarcz; Fiscal Year: 2013
    ....
  50. Quantification of breast density using dual energy mammography
    Sabee Molloi; Fiscal Year: 2013
    ..The long-range plan for this project is to develop a clinically feasible method to measure the density of a woman's breast with dual energy x-ray mammography. ..
  51. Clinical and Preclinical Models in Drug Abuse: Training and Development
    Richard W Foltin; Fiscal Year: 2013
    ..This model has worked well in the past and will be used to develop new K awards for junior faculty. ..
  52. Lyophilization of Plasmodium falciparum sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..Additionally, a dried vaccine may accelerate a concerted world-wide effort to eradicate this devastating disease. [unreadable] [unreadable] [unreadable]..
  53. A preclinical assessment of monthly intramuscular GSK1265744, an InSTI, as PrEP
    MARTIN H MARKOWITZ; Fiscal Year: 2013
    ....
  54. MicroRNA and protein profiling in melanocytes exposed to solar UVR in situ
    MLNIKKI L HARTER; Fiscal Year: 2013
    ..b) Use this new class of proteomic profiling technology to analyze the potentially altered state of molecular pathways relevant to the early development of melanoma. ..
  55. Race and Human Experimentation in the Eighteenth-Century Atlantic World
    Londa Schiebinger; Fiscal Year: 2013
    ..the eighteenth-century Atlantic world, exploring how newly developing concepts of race and sex figured in human experimentation. Specifically, this research analyzes how human subjects were chosen for experiments, and how notions of ..
  56. Diffusion MRI of Complex White Matter and Connectivity
    Van J Wedeen; Fiscal Year: 2013
    ....
  57. PARP inhibitor therapy for septic shock
    Andrew Salzman; Fiscal Year: 2004
    ..Based on pre-clinical porcine shock models and clinical safety studies, we expect INO-1001 to be a safe, well-tolerated and effective therapeutic in patients with septic shock. ..
  58. Characterizing habitual and goal-directed behavioral control systems in the human
    JOHN P O'DOHERTY; Fiscal Year: 2013
    ..Ultimately this research has the potential to lead to the development of new mechanisms for inducing habitual control in order to achieve the maintenance of adaptive and healthful behaviors. ..
  59. HIV-Specific B Cell Repertoire in Humans Following Cross-Clade Immunization
    Paul W Spearman; Fiscal Year: 2013
    ..These data will provide important new information that will inform the design of HIV vaccine regimens designed to elicit broadly- neutralizing antibodies. ..
  60. N-acetylcysteine as a Potential Treatment for Methamphetamine Dependence
    THOMAS FREDERICK NEWTON; Fiscal Year: 2010
    ....
  61. Ventilation Stethoscope using Hyperpolarized Xenon
    Samuel Patz; Fiscal Year: 2013
    ..With this device, we propose to demonstrate the measurement of regional ventilation in healthy adult human volunteers. ..
  62. A handheld scanner for clinical oximetry
    Periannan Kuppusamy; Fiscal Year: 2013
    ....
  63. Multi-view, Photon Counting DXA Scanner for Quantitative Musculoskeletal Imaging
    Thomas J Beck; Fiscal Year: 2011
    ..If successful a scanner capable of scanning patients either erect or recumbent will be built in Phase 2 and tested on human volunteers. ..
  64. Improving Production of Attenuated Malaria Sporozoite Vaccines through Genetic Mo
    Peter Billingsley; Fiscal Year: 2009
    ..Success in this project will significantly decrease the cost of development and production of the vaccine, and reduce the time to market for this malaria vaccine. ..
  65. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  66. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  67. IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDE
    JOHN GRIFFISS; Fiscal Year: 2003
    ..Gonococci shed during gonorrhoea make larger LOS. The higher Mr LOS made by MS11mkC - a strain used in human experimentation -have polylactosamine structures...
  68. LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS
    CARROLL CROSS; Fiscal Year: 2000
    ..This information is likely to increase our understanding of lung injury due to inhalation of air pollutants, and will enable development of strategies to prevent lung injury by inhaled oxidants. ..
  69. Potency of cryopreserved, irradiated sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2005
    ..The project will also provide a method for cryopreserving unirradiated sporozoites that could be used to challenge volunteers by injection with P. falciparum in vaccine studies worldwide. ..
  70. AGING EFFECT ON DRUG BIOAVAILABILITY
    Stephen Hall; Fiscal Year: 1999
    ..However, the choice of model compounds will also provide a general understanding of the mechanism of interactions between CYP3A substrates and the modulation of these interactions by advanced age. ..
  71. Gene-engineered dendritic cell therapy for diabetics
    Massimo Trucco; Fiscal Year: 2003
    ..The ultimate result could include less intensive or even a complete cessation of insulin replacement therapy in newly-diagnosed diabetics as well as, perhaps, a means of preventing diabetes. ..
  72. Gene-engineered dendritic cell therapy for diabetics
    Massimo Trucco; Fiscal Year: 2006
    ..The ultimate result could include less intensive or even a complete cessation of insulin replacement therapy in newly-diagnosed diabetics as well as, perhaps, a means of preventing diabetes. ..
  73. Inhalation Dosimetry/Exposure Index of Fiber Aerosol
    Yung Sung Cheng; Fiscal Year: 2006
    ..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
  74. SEVERE PERIODONTITIS AS A RHEOLOGIC MODIFIER
    STEVEN ENGEBRETSON; Fiscal Year: 2003
    ..Dr. Engebretson will receive training in research methodology and molecular biology in order to explore the mechanisms of periodontal medicine through the conduct of human clinical studies as a career goal. ..
  75. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..abstract_text> ..
  76. DUODENOGASTRIC REFLUX IN HEALTH AND DISEASE
    Ronald Hinder; Fiscal Year: 1991
    ..The results of this project will provide a better understanding of the phenomenon of DGR, more definitive diagnosis of pathologic DGR, and will explore the physiological advantages of a new surgical therapy...
  77. PH CONTROL OF PROTEIN SYNTHESIS
    Peter Garlick; Fiscal Year: 2003
    ..abstract_text> ..