statistical data interpretation

Summary

Summary: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.

Top Publications

  1. ncbi Prediction error estimation: a comparison of resampling methods
    Annette M Molinaro
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD 20852, USA
    Bioinformatics 21:3301-7. 2005
  2. ncbi Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    Rafael A Irizarry
    Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA
    Biostatistics 4:249-64. 2003
  3. ncbi Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems
    Stuart J Pocock
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Stat Med 21:2917-30. 2002
  4. ncbi Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    Wolfgang Huber
    Department of Molecular Genome Analysis, German Cancer Research Center, INF 280, Heidelberg, 69120, Germany
    Bioinformatics 18:S96-104. 2002
  5. pmc Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation
    Matthew Stephens
    Department of Statistics, University of Washington, Seattle, WA 98195 4322, USA
    Am J Hum Genet 76:449-62. 2005
  6. pmc Bias in random forest variable importance measures: illustrations, sources and a solution
    Carolin Strobl
    Institut für Statistik, Ludwig Maximilians Universitat Munchen, Ludwigstr, 33, 80539 Munchen, Germany
    BMC Bioinformatics 8:25. 2007
  7. ncbi Quantitative real-time RT-PCR data analysis: current concepts and the novel "gene expression's CT difference" formula
    Jan H Schefe
    Center for Cardiovascular Research CCR Institute of Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115, Berlin, Germany
    J Mol Med (Berl) 84:901-10. 2006
  8. ncbi Statistics in medicine--reporting of subgroup analyses in clinical trials
    Rui Wang
    N Engl J Med 357:2189-94. 2007
  9. ncbi Patterns of intra-cluster correlation from primary care research to inform study design and analysis
    Geoffrey Adams
    Department of Public Health Sciences, King s College London, Capital House, 42 Weston Street, London SE1 3QD, UK
    J Clin Epidemiol 57:785-94. 2004
  10. ncbi Validating the independent components of neuroimaging time series via clustering and visualization
    Johan Himberg
    Neural Networks Research Centre, Helsinki University of Technology, Helsinki, Finland
    Neuroimage 22:1214-22. 2004

Detail Information

Publications332 found, 100 shown here

  1. ncbi Prediction error estimation: a comparison of resampling methods
    Annette M Molinaro
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD 20852, USA
    Bioinformatics 21:3301-7. 2005
    ..With a focus on prediction assessment, we compare several methods for estimating the 'true' prediction error of a prediction model in the presence of feature selection...
  2. ncbi Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    Rafael A Irizarry
    Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA
    Biostatistics 4:249-64. 2003
    ..We conclude that there is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities...
  3. ncbi Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems
    Stuart J Pocock
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Stat Med 21:2917-30. 2002
    ....
  4. ncbi Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    Wolfgang Huber
    Department of Molecular Genome Analysis, German Cancer Research Center, INF 280, Heidelberg, 69120, Germany
    Bioinformatics 18:S96-104. 2002
    ..We demonstrate our approach on data sets from different experimental platforms, including two-colour cDNA arrays and a series of Affymetrix oligonucleotide arrays...
  5. pmc Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation
    Matthew Stephens
    Department of Statistics, University of Washington, Seattle, WA 98195 4322, USA
    Am J Hum Genet 76:449-62. 2005
    ..Our method is implemented in the software package PHASE (v2.1.1), available from the Stephens Lab Web site...
  6. pmc Bias in random forest variable importance measures: illustrations, sources and a solution
    Carolin Strobl
    Institut für Statistik, Ludwig Maximilians Universitat Munchen, Ludwigstr, 33, 80539 Munchen, Germany
    BMC Bioinformatics 8:25. 2007
    ....
  7. ncbi Quantitative real-time RT-PCR data analysis: current concepts and the novel "gene expression's CT difference" formula
    Jan H Schefe
    Center for Cardiovascular Research CCR Institute of Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115, Berlin, Germany
    J Mol Med (Berl) 84:901-10. 2006
    ..Additionally, this article offers some technical considerations and information on statistical analysis of real-time PCR data...
  8. ncbi Statistics in medicine--reporting of subgroup analyses in clinical trials
    Rui Wang
    N Engl J Med 357:2189-94. 2007
  9. ncbi Patterns of intra-cluster correlation from primary care research to inform study design and analysis
    Geoffrey Adams
    Department of Public Health Sciences, King s College London, Capital House, 42 Weston Street, London SE1 3QD, UK
    J Clin Epidemiol 57:785-94. 2004
    ..To provide information concerning the magnitude of the intraclass correlation coefficient (ICC) for cluster-based studies set in primary care...
  10. ncbi Validating the independent components of neuroimaging time series via clustering and visualization
    Johan Himberg
    Neural Networks Research Centre, Helsinki University of Technology, Helsinki, Finland
    Neuroimage 22:1214-22. 2004
    ..The method is implemented in a software package called Icasso...
  11. ncbi ROCR: visualizing classifier performance in R
    Tobias Sing
    Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrucken, Germany
    Bioinformatics 21:3940-1. 2005
    ..Being equipped with only three commands and reasonable default values for optional parameters, ROCR combines flexibility with ease of usage...
  12. pmc Metagenes and molecular pattern discovery using matrix factorization
    Jean Philippe Brunet
    The Eli and Edythe L Broad Institute, Massachusetts Institute of Technology and Harvard University, 320 Charles Street, Cambridge, MA 02141, USA
    Proc Natl Acad Sci U S A 101:4164-9. 2004
    ..This ability, similar to semantic polysemy in text, provides a general method for robust molecular pattern discovery...
  13. pmc GoMiner: a resource for biological interpretation of genomic and proteomic data
    Barry R Zeeberg
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 4:R28. 2003
    ..The first is a tree-like structure analogous to that in the AmiGO browser and the second is a compact, dynamically interactive 'directed acyclic graph'. Genes displayed in GoMiner are linked to major public bioinformatics resources...
  14. ncbi Missing value estimation methods for DNA microarrays
    O Troyanskaya
    Stanford Medical Informatics Stanford University School of Medicine, Stanford, CA, USA
    Bioinformatics 17:520-5. 2001
    ..We report results of the comparative experiments and provide recommendations and tools for accurate estimation of missing microarray data under a variety of conditions...
  15. ncbi Statistical methods for identifying differentially expressed genes in DNA microarrays
    John D Storey
    Department of Statistics, Stanford University, Palo Alto, CA, USA
    Methods Mol Biol 224:149-57. 2003
  16. ncbi Computational cluster validation in post-genomic data analysis
    Julia Handl
    School of Chemistry, University of Manchester, Faraday Building, Sackville Street, PO Box 88, Manchester M60 1QD, UK
    Bioinformatics 21:3201-12. 2005
    ..Suitable computational cluster validation techniques are available in the general data-mining literature, but have been given only a fraction of the same attention in bioinformatics...
  17. ncbi Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker
    Margaret Sullivan Pepe
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 159:882-90. 2004
    ..In addition, the serious pitfalls of using more traditional methods based on parameters in logistic regression models are illustrated...
  18. pmc WebGestalt: an integrated system for exploring gene sets in various biological contexts
    Bing Zhang
    Graduate School in Genome Science and Technology, University of Tennessee Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Nucleic Acids Res 33:W741-8. 2005
    ..Exploration of all the 48 gene sets using WebGestalt is available for the public at http://genereg.ornl.gov/webgestalt/wg_enrich.php...
  19. pmc Evaluating different methods of microarray data normalization
    Andre Fujita
    Institute of Mathematics and Statistics, University of Sao Paulo, Rua do Matao, 1010 São Paulo, 05508 090 SP, Brazil
    BMC Bioinformatics 7:469. 2006
    ..Due to technical biases, normalization of the intensity levels is a pre-requisite to performing further statistical analyses. Therefore, choosing a suitable approach for normalization can be critical, deserving judicious consideration...
  20. ncbi Subgroup analyses in randomised controlled trials: quantifying the risks of false-positives and false-negatives
    S T Brookes
    Department of Social Medicine, University of Bristol, UK
    Health Technol Assess 5:1-56. 2001
    ....
  21. ncbi Analyzing gene expression data in terms of gene sets: methodological issues
    Jelle J Goeman
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Bioinformatics 23:980-7. 2007
    ..This article aims to clarify the assumptions behind different approaches and to indicate a preferential methodology of gene set testing...
  22. ncbi Clustering by passing messages between data points
    Brendan J Frey
    Department of Electrical and Computer Engineering, University of Toronto, 10 King s College Road, Toronto, Ontario M5S 3G4, Canada
    Science 315:972-6. 2007
    ..Affinity propagation found clusters with much lower error than other methods, and it did so in less than one-hundredth the amount of time...
  23. ncbi External validity of randomised controlled trials: "to whom do the results of this trial apply?"
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 365:82-93. 2005
    ..This review discusses those determinants, presents a checklist for clinicians, and makes recommendations for greater consideration of external validity in the design and reporting of RCTs...
  24. ncbi Caution regarding the use of pilot studies to guide power calculations for study proposals
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA
    Arch Gen Psychiatry 63:484-9. 2006
    ..The argument herein is not meant to discourage clinical researchers from performing pilot studies (or review committees from requiring them) but simply to caution against their use for the objective of guiding power calculations...
  25. pmc Meta-analysis, Simpson's paradox, and the number needed to treat
    Douglas G Altman
    Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford, UK
    BMC Med Res Methodol 2:3. 2002
    ..There is debate concerning methods for calculating numbers needed to treat (NNT) from results of systematic reviews...
  26. ncbi Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion
    Wen Fury
    Regeneron Pharmaceutical Inc, Tarrytown, NY 10591, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5531-4. 2006
    ..It is concluded that overlapping probability is indeed a function of the gene list length, and its statistical significance should be quoted in the context of gene selection criterion...
  27. pmc Systematic analysis of bicistronic reporter assay data
    Jonathan L Jacobs
    Department of Cell Biology and Molecular Genetics, 2135 Microbiology Building, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 32:e160. 2004
    ..umd.edu/statistics). These spreadsheets could be easily adapted to any bicistronic reporter assay system...
  28. ncbi Feed forward neural networks for the analysis of censored survival data: a partial logistic regression approach
    E Biganzoli
    Divsione di Statistica Medica e Biometria, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Stat Med 17:1169-86. 1998
    ....
  29. ncbi Protein function in the post-genomic era
    D Eisenberg
    Molecular Biology Institute and UCLA DOE Laboratory of Structural Biology and Molecular Medicine, University of California at Los Angeles, 90095 1570, USA
    Nature 405:823-6. 2000
    ....
  30. ncbi Outlier sums for differential gene expression analysis
    Robert Tibshirani
    Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA
    Biostatistics 8:2-8. 2007
    ..We also compare our approach to the recent cancer profile outlier analysis proposal of Tomlins and others (2005)...
  31. ncbi Design and analysis of clinical trials with clustering effects due to treatment
    Chris Roberts
    Biostatistics Group, Division of Epidemiology and Health Sciences, University of Manchester, UK
    Clin Trials 2:152-62. 2005
    ..It is argued that the design and analysis of this type of trial should take account of possible heterogeneity in cluster size and intracluster correlation...
  32. ncbi Dynamic brain sources of visual evoked responses
    S Makeig
    Computational Neurobiology Laboratory and, The Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA
    Science 295:690-4. 2002
    ..Scalp topographies of these components were consistent with their generation in compact cortical domains...
  33. pmc Factors affecting statistical power in the detection of genetic association
    Derek Gordon
    Laboratory of Statistical Genetics, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 115:1408-18. 2005
    ..We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes...
  34. pmc g:Profiler--a web-based toolset for functional profiling of gene lists from large-scale experiments
    Jüri Reimand
    Institute of Computer Science, University of Tartu, Liivi 2, 50409 Tartu, Estonia
    Nucleic Acids Res 35:W193-200. 2007
    ..g:Profiler supports 31 different species, and underlying data is updated regularly from sources like the Ensembl database. Bioinformatics communities wishing to integrate with g:Profiler can use alternative simple textual outputs...
  35. ncbi Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting
    Alain Dupuy
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Natl Cancer Inst 99:147-57. 2007
    ..There is a need for critical review of the statistical analysis and reporting in published microarray studies that focus on cancer-related clinical outcomes...
  36. ncbi Intraclass correlation coefficient and outcome prevalence are associated in clustered binary data
    M C Gulliford
    Department of Public Health Sciences, King s College London, Capital House, 42 Weston St, London SE1 3QD, UK
    J Clin Epidemiol 58:246-51. 2005
    ..To describe the association between values for a proportion and the intraclass correlation coefficient (ICC)...
  37. ncbi Computing average shaped tissue probability templates
    John Ashburner
    Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 45:333-41. 2009
    ..g. grey and white matter) are registered simultaneously with the current template estimate. In order to generalise the resulting template to a broader range of subjects, a template blurriness prior is included within the model...
  38. ncbi Inferring and validating horizontal gene transfer events using bipartition dissimilarity
    Alix Boc
    Departement d informatique, Universite du Quebec a Montreal, C P 8888, Succ Centre Ville, Montreal, Quebec, Canada
    Syst Biol 59:195-211. 2010
    ..Finally, a statistical framework for assessing the reliability of obtained HGTs by bootstrap analysis is also presented...
  39. ncbi Enrichment or depletion of a GO category within a class of genes: which test?
    Isabelle Rivals
    Equipe de Statistique Appliquée, 10 rue Vauquelin, 75005 Paris, France
    Bioinformatics 23:401-7. 2007
    ..Whereas a correct formulation of the problem leads to a single exact null distribution, these GO tools use a large variety of statistical tests whose denominations often do not clarify the underlying P-value computations...
  40. ncbi Time-series studies of particulate matter
    Michelle L Bell
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Annu Rev Public Health 25:247-80. 2004
    ....
  41. ncbi Global functional profiling of gene expression
    Sorin Draghici
    Department of Computer Science, Wayne State University, 5143 Cass Avenue, Detroit, MI 48202, USA
    Genomics 81:98-104. 2003
    ..OE was able to identify correctly all biological processes postulated by the original authors, as well as discover novel relevant mechanisms...
  42. ncbi Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    Kirk E Lohmueller
    Whitehead Massachuetts Institute of Technology Center for Genome Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:177-82. 2003
    ..We conclude that there are probably many common variants in the human genome with modest but real effects on common disease risk, and that studies using large samples will convincingly identify such variants...
  43. pmc Detection of functional DNA motifs via statistical over-representation
    Martin C Frith
    Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Nucleic Acids Res 32:1372-81. 2004
    ..It also demonstrates superior performance over two contingency table based over-representation methods. In conclusion, Clover has the potential to greatly accelerate characterization of signals that regulate transcription...
  44. pmc Evaluating cutpoints for the MHI-5 and MCS using the GHQ-12: a comparison of five different methods
    Mark J Kelly
    Dept of Primary Care and Public Health, Centre for Health Sciences Research, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4YS, UK
    BMC Psychiatry 8:10. 2008
    ..This paper aims to produce cutpoints for the MHI-5 and MCS by comparison with the General Health Questionnaire (GHQ-12)...
  45. pmc Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
    Haseong Kim
    Interdisciplinary Program in Bioinformatics, Seoul National University, South Korea
    BMC Bioinformatics 8:37. 2007
    ..We propose a variable selection method that are not only reduces BN computation times significantly but also obtains optimal network constructions by using chi-square statistics for testing the independence in contingency tables...
  46. ncbi Some methods of propensity-score matching had superior performance to others: results of an empirical investigation and Monte Carlo simulations
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Biom J 51:171-84. 2009
    ..2 of the standard deviation of the logit of the propensity score and the use of calipers of width 0.02 and 0.03 tended to have superior performance for estimating treatment effects...
  47. ncbi Randomized controlled trials with time-to-event outcomes: how much does prespecified covariate adjustment increase power?
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Epidemiol 16:41-8. 2006
    ..We evaluated the effects of various strategies of covariate adjustment on type I error, power, and potential reduction in sample size in randomized controlled trials (RCTs) with time-to-event outcomes...
  48. ncbi A substantial and confusing variation exists in handling of baseline covariates in randomized controlled trials: a review of trials published in leading medical journals
    Peter C Austin
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Clin Epidemiol 63:142-53. 2010
    ..Furthermore, some have advocated for the use of regression adjustment to estimate the effect of treatment after adjusting for potential imbalances in prognostically important baseline covariates between treatment groups...
  49. pmc Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome
    Mark Bieda
    Department of Pharmacology and the Genome Center, University of California Davis, Davis, California 95616, USA
    Genome Res 16:595-605. 2006
    ....
  50. ncbi Microarray data normalization and transformation
    John Quackenbush
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Genet 32:496-501. 2002
    ....
  51. ncbi Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach
    Miguel Perez-Enciso
    Station d Amélioration Génétique des Animaux, Institut National de la Recherche Agronomique, BP 27, 31326 Castanet Tolosan, France
    Hum Genet 112:581-92. 2003
    ..We conclude that PLS-DA is a powerful yet simple tool for analysing microarray data...
  52. ncbi Multiple imputation: a primer
    J L Schafer
    Department of Statistics, Pennsylvania State University, University Park 16802 6202, USA
    Stat Methods Med Res 8:3-15. 1999
    ..Essential features of multiple imputation are reviewed, with answers to frequently asked questions about using the method in practice...
  53. ncbi A review and comparison of classification algorithms for medical decision making
    Paul R Harper
    School of Mathematics, University of Southampton, SO17 1BJ, Southampton, UK
    Health Policy 71:315-31. 2005
    ....
  54. ncbi Molecular taxonomy of major neuronal classes in the adult mouse forebrain
    Ken Sugino
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, MS 008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
    Nat Neurosci 9:99-107. 2006
    ..This dataset should be useful for the classification of unknown neuronal subtypes, the investigation of specifically expressed genes and the genetic manipulation of specific neuronal circuit elements...
  55. ncbi Localization of the event-related potential novelty response as defined by principal components analysis
    Joseph Dien
    Department of Psychology, University of Illinois, Urbana Champaign, IL, USA
    Brain Res Cogn Brain Res 17:637-50. 2003
    ..Source modeling on 129-channel data with BESA and BrainVoyager suggests the P300 has sources in the temporal-parietal junction whereas the Novelty P3 has sources in the anterior cingulate...
  56. ncbi Diagnosis and exploration of massively univariate neuroimaging models
    Wen lin Luo
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroimage 19:1014-32. 2003
    ..We apply our methods to a fMRI data set, demonstrating their ability to localize subtle artifacts and to discover systematic experimental variation not captured by the model...
  57. ncbi A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes
    P Baldi
    Department of Information and Computer Science, University of California at Irvine, Irvine, CA 92697 3425, USA
    Bioinformatics 17:509-19. 2001
    ..Current methods are unsatisfactory due to the lack of a systematic framework that can accommodate noise, variability, and low replication often typical of microarray data...
  58. pmc Incongruence between test statistics and P values in medical papers
    Emili García-Berthou
    Department of Environmental Sciences, University of Girona, E 17071 Girona, Spain
    BMC Med Res Methodol 4:13. 2004
    ..Given an observed test statistic and its degrees of freedom, one may compute the observed P value with most statistical packages. It is unknown to what extent test statistics and P values are congruent in published medical papers...
  59. ncbi Statistical issues in cDNA microarray data analysis
    Gordon K Smyth
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Methods Mol Biol 224:111-36. 2003
  60. pmc Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide
    Karl Brendel
    INSERM U738, Paris, France
    Pharm Res 23:2036-49. 2006
    ..The aim of this study is to define and illustrate metrics for the external evaluation of a population model...
  61. ncbi Neural substrates of faulty decision-making in abstinent marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Neuroimage 26:480-92. 2005
    ..Finally, it is unclear if these neurologic findings will become progressively worse with continued heavy MJ use or if they will resolve with abstinence from MJ use...
  62. ncbi Molecular systematics of the Eastern Fence Lizard (Sceloporus undulatus): a comparison of Parsimony, Likelihood, and Bayesian approaches
    Adam D Leaché
    Department of Biology, San Diego State University, San Diego, California 92182 4614, USA
    Syst Biol 51:44-68. 2002
    ..This evidence, along with convincing patterns of phylogeographic differentiation suggests "S. undulatus" represents at least four lineages that should be recognized as evolutionary species...
  63. ncbi Seven items were identified for inclusion when reporting a Bayesian analysis of a clinical study
    Lillian Sung
    Division of Hematology Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Epidemiol 58:261-8. 2005
    ....
  64. ncbi Highly parallel SNP genotyping
    J B Fan
    llumina, Inc, San Diego, California 92121, USA
    Cold Spring Harb Symp Quant Biol 68:69-78. 2003
  65. ncbi The bootstrap: a technique for data-driven statistics. Using computer-intensive analyses to explore experimental data
    A Ralph Henderson
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Clin Chim Acta 359:1-26. 2005
    ..Most of the published literature is concerned with the mathematical aspects of the bootstrap but increasingly this technique is being utilized in medical and other fields...
  66. pmc A statistical approach for array CGH data analysis
    Franck Picard
    Institut National Agronomique Paris Grignon, UMR INAPG ENGREF INRA MIA 518, Paris, France
    BMC Bioinformatics 6:27. 2005
    ..Two major problems arise: to determine which parameters are affected by the abrupt changes (the mean and the variance, or the mean only), and the selection of the number of segments in the profile...
  67. pmc Tilescope: online analysis pipeline for high-density tiling microarray data
    Zhengdong D Zhang
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Genome Biol 8:R81. 2007
    ..The program is designed with a modular, three-tiered architecture, facilitating parallelism, and a graphic user-friendly interface, presenting results in an organized web page, downloadable for further analysis...
  68. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
    ..We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk...
  69. ncbi Rosetta error model for gene expression analysis
    Lee Weng
    Rosetta Inpharmatics LLC 401 Terry Avenue North, Seattle, WA 98109, USA
    Bioinformatics 22:1111-21. 2006
    ..The unreliable variance estimation is further complicated by the fact that the technology-specific variance is intrinsically intensity-dependent...
  70. ncbi End points for colon cancer adjuvant trials: observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 randomized trials from the ACCENT Group
    Daniel J Sargent
    Department of Health Sciences Research, North Central Cancer Treatment Group, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 25:4569-74. 2007
    ..We previously validated disease-free survival (DFS) after 3-year follow-up as an excellent predictor of 5-year OS results. Here we explore shorter term DFS and OS end points, as well as stage dependency...
  71. ncbi Clinical reasoning: the relative contribution of identification, interpretation and hypothesis errors to misdiagnosis
    Michele Groves
    Faculty of Biological and Chemical Sciences, University of Queensland, St Lucia 4072, Australia
    Med Teach 25:621-5. 2003
    ....
  72. pmc Interpreting the results of patient reported outcome measures in clinical trials: the clinician's perspective
    Holger J Schunemann
    Division of Clinical Research Development and INFORMAtion Translation, Department of Epidemiology, Istituto Regina Elena Italian National Cancer Institute Rome, Rome, Italy
    Health Qual Life Outcomes 4:62. 2006
    ..Thus, there are several steps investigators can take to facilitate this process to help bringing HRQL information closer to the bedside...
  73. pmc DBD-Hunter: a knowledge-based method for the prediction of DNA-protein interactions
    Mu Gao
    Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, 250 14th Street NW, Atlanta, GA 30318, USA
    Nucleic Acids Res 36:3978-92. 2008
    ..DBD-Hunter is freely available at http://cssb.biology.gatech.edu/skolnick/webservice/DBD-Hunter/...
  74. ncbi A comparison of methods for estimating the causal effect of a treatment in randomized clinical trials subject to noncompliance
    Roderick J Little
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biometrics 65:640-9. 2009
    ..Methods are illustrated on data from the Women Take Pride study, an assessment of behavioral treatments for women with heart disease...
  75. pmc A guide to modern statistical analysis of immunological data
    Bernd Genser
    BMC Immunol 8:27. 2007
    ..Such approaches are used in many other scientific disciplines, but immunological studies on the whole still use simple statistical techniques for data analysis...
  76. ncbi An accessible analytical approach for investigating what happens between the rounds of a Delphi study
    J Greatorex
    University of Cambridge Local Examinations Syndicate, England
    J Adv Nurs 32:1016-24. 2000
    ..An example Delphi study from a healthcare setting is used to illustrate the methodology...
  77. ncbi Estimation and prediction in a multi-state model for breast cancer
    Hein Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
    Biom J 48:366-80. 2006
    ..The estimated transition rates between the states in the model are used to obtain predictions for patients with a given history. Formulas are developed and illustrated for these prediction probabilities for the clock reset approach...
  78. pmc Theoretical uncertainty of measurements using quantitative polymerase chain reaction
    J Peccoud
    TIMC IMAG, Institut Albert Bonniot, Faculte de Medecine de Grenoble, La Tronche
    Biophys J 71:101-8. 1996
    ..The confidence interval amplitude is the theoretical uncertainty of measurements using quantitative PCR. We expect these results to be applicable to the data produced by the next generation of thermocyclers for quantitative applications...
  79. ncbi Statistical evaluation of learning curve effects in surgical trials
    Jonathan A Cook
    Health Services Research Unit, University of Aberdeen, Foresterhill, UK
    Clin Trials 1:421-7. 2004
    ..Bayesian hierarchical models are proposed to adjust the trial results for the existence of a learning curve effect. The implications for trial evaluation and data collection are considered...
  80. ncbi Fast detection of arbitrarily shaped disease clusters
    R Assunção
    Departamento de Estatistica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG Brazil
    Stat Med 25:723-42. 2006
    ..This calls for a new approach different from the maximum likelihood method for this important public health problem...
  81. pmc Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported
    Marion K Campbell
    Health Services Research Unit, University of Aberdeen, Aberdeen, UK
    BMC Med Res Methodol 4:9. 2004
    ..Similarly, the need for appropriate standards of reporting of cluster trials is more widely acknowledged...
  82. ncbi New gene selection method for classification of cancer subtypes considering within-class variation
    Ji Hoon Cho
    Department of Chemical Engineering, Pohang University of Science and Technology, San 31 Hyoja Dong, 790 784 Pohang, South Korea
    FEBS Lett 551:3-7. 2003
    ..The proposed method provides a very small number of genes compared with the previous methods without loss of discriminating power and thus it can effectively facilitate further biological and clinical researches...
  83. ncbi Hidden likelihood support in genomic data: can forty-five wrongs make a right?
    John Gatesy
    Department of Biology, University of California Riverside, Riverside, CA 92521, USA
    Syst Biol 54:483-92. 2005
    ..Consensus and supertree procedures that ignore hidden phylogenetic signals are, at best, incomplete...
  84. ncbi Statistics in medical journals: some recent trends
    D G Altman
    ICRF Medical Statistics Group, Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Oxford OX3 7LF, UK
    Stat Med 19:3275-89. 2000
    ..I also consider developments in the reporting of research in medical journals...
  85. pmc DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists
    Da Wei Huang
    Laboratory of Immunopathogenesis and Bioinformatics, SAIC Frederick, Inc, National Cancer Institute at Frederick, MD 21702, USA
    Nucleic Acids Res 35:W169-75. 2007
    ..With DAVID (http://david.niaid.nih.gov), investigators gain more power to interpret the biological mechanisms associated with large gene lists...
  86. ncbi Ipsilateral motor cortex activation on functional magnetic resonance imaging during unilateral hand movements is related to interhemispheric interactions
    Masahito Kobayashi
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 20:2259-70. 2003
    ..Instead, IpsiLM1 may reveal an enhanced interhemispheric inhibition from the right hemisphere upon the left to suppress superfluous, excessive activation...
  87. pmc Identifying null meta-analyses that are ripe for updating
    Nicholas J Barrowman
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 3:13. 2003
    ..As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date...
  88. ncbi Association between unreported outcomes and effect size estimates in Cochrane meta-analyses
    Toshi A Furukawa
    JAMA 297:468-70. 2007
  89. ncbi Adjustments and measures of differential expression for microarray data
    A Tsodikov
    Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112 5550, USA
    Bioinformatics 18:251-60. 2002
    ..Given a considerable diversity of data adjustment procedures, the question of their performance, comparison and ranking for various microarray experiments was of interest...
  90. ncbi A review of ordinal regression models applied on health-related quality of life assessments
    R Lall
    Institute of General Practice and Primary Care, University of Sheffield, Community Sciences Centre, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Stat Methods Med Res 11:49-67. 2002
    ..Different methods of generating scores yield data with different properties. It is now possible to fit a variety of ordinal regression models and so select the appropriate one that correctly models the data...
  91. pmc The application of statistical physics to evolutionary biology
    Guy Sella
    Center for the Study of Rationality, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 102:9541-6. 2005
    ..Finally, just as the free energy function quantitatively characterizes the balance between energy and entropy, a free fitness function provides an analytical expression for the balance between natural selection and stochastic drift...
  92. ncbi Analysis of data with excess zeros
    Peter A Lachenbruch
    FDA Center for Biologics Research and Review, Office of Biostatistics and Epidemiology, Rockville, MD, USA
    Stat Methods Med Res 11:297-302. 2002
    ..The second part of the paper summarizes results of a study of the size and power of two-part models. It proposes that two-part models are a useful alternative to the t-test and the Wilcoxon test...
  93. ncbi Research guidelines for the Delphi survey technique
    F Hasson
    Centre for Nursing Research, University of Ulster, Newtownabbey, Northern Ireland
    J Adv Nurs 32:1008-15. 2000
    ..The paper does not claim to be definitive; it purports to act as a guide for those researchers who wish to exploit the Delphi methodology...
  94. ncbi Codelink: an R package for analysis of GE healthcare gene expression bioarrays
    Diego Diez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Bioinformatics 23:1168-9. 2007
    ..Here, we report the availability of a package for reading and analyzing data from GE Healthcare Gene Expression Bioarrays within the R environment...
  95. pmc Why most published research findings are false
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Med 2:e124. 2005
    ..In this essay, I discuss the implications of these problems for the conduct and interpretation of research...
  96. ncbi Biological profiling of gene groups utilizing Gene Ontology
    Nils Blüthgen
    Institute for Theoretical Biology, Humboldt University Berlin, Germany
    Genome Inform 16:106-15. 2005
    ..The software package GOSSIP implements our method and is made freely available at http://gossip.gene-groups.net/...
  97. ncbi A general best-fit method for concentration-response curves and the estimation of low-effect concentrations
    M Scholze
    Department of Biology and Chemistry, University of Bremen, Germany
    Environ Toxicol Chem 20:448-57. 2001
    ..In comparison with common methods of concentration-response analysis, a clear improvement is achieved...
  98. ncbi Combining multiple microarray studies and modeling interstudy variation
    Jung Kyoon Choi
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 371 1 Guseong dong Yuseong gu, Daejeon 305 701, Korea
    Bioinformatics 19:i84-90. 2003
    ..We also developed an alternative modeling procedure based on a Bayesian approach, which would offer flexibility and robustness compared to the classical procedure...
  99. ncbi Determination of activation areas in the human auditory cortex by means of synthetic aperture magnetometry
    Anthony T Herdman
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Canada M6A 2E1
    Neuroimage 20:995-1005. 2003
    ..Source waveforms from SAM and ECD analyses show comparable temporal information. Results from this study suggest that SAM is a useful technique for imaging cortical structures involved in processing perceptual information...
  100. ncbi Exploring the demographic history of DNA sequences using the generalized skyline plot
    K Strimmer
    Department of Zoology, University of Oxford
    Mol Biol Evol 18:2298-305. 2001
    ..We investigate the performance of our approach using simulation and subsequently apply it to HIV-1 sequences from central Africa and mtDNA sequences from red pandas...
  101. ncbi SVDMAN--singular value decomposition analysis of microarray data
    M E Wall
    Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Bioinformatics 17:566-8. 2001
    ....

Research Grants64

  1. Regulation of Apical-Basal Cell polarity during Intestinal Epithelial Morphogenes
    Nan Gao; Fiscal Year: 2013
    ..The award will protect my time for generating new genetic models including the intestine-specific Cdc42 knockout mice. ..
  2. Clinical Research Consortium for Spinocerebellar Ataxias
    Tetsuo Ashizawa; Fiscal Year: 2010
    ..We will establish a clinical research consortium for SCA (CRC-SCA), which will provide multidisciplinary infrastructure to bring these novel treatment ideas to bedside. ..
  3. Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise Training
    Rong Zhang; Fiscal Year: 2012
    ..The new knowledge will have significant impact on prevention or treatment of AD. ..
  4. Statistical Models for Genome Sequencing and Association
    Nancy R Zhang; Fiscal Year: 2013
    ..Public, open source software will be made available for all of the developed methods. ..
  5. Statistical Methods for Incomplete Data with Measurement Errors
    Edward C Chao; Fiscal Year: 2012
    ..There is no commercial software to deal with complicated case as Laso. PUBLIC HEALTH RELEVANCE: This project aims to develop statistical methods and tools for analyzing incomplete data with missing data and measurement errors. ..
  6. Bayesian Variable Selection in Generalized Linear Models with Missing Varibles
    Xiaowei Yang; Fiscal Year: 2013
    ..Development of these procedures and contribution of the software to statisticians and researchers in medical research would significantly improve the quality of evaluation of important and clinically relevant data. ..
  7. Longitudinal Effects of Family Violence on the Dev of Delinquency & Aggression
    MIGUEL T VILLODAS; Fiscal Year: 2010
    ..In addition, the applicant will contribute to the academic community through publication in professional journals and presentations at international and national conferences. ..
  8. The Effect of Exercise on Progression of Knee OA
    ANDREW CONCOFF; Fiscal Year: 2003
    ..Eventually, optimal exercise regimens will be sought for both primary and secondary prevention of OA at various joints and stages. ..
  9. Serum-based assays for pancreatic cancer detection
    ROSAURA VALLE; Fiscal Year: 2009
    ..The development of a simple immunodiagnostic assay based on patient serum to detect pancreatic cancer would have a profound impact on patient survival and reduce mortality from this disease. ..
  10. EFFECT OF ELEVATED FREE FATTY ACIDS ON INSULIN SECRETION
    Melissa Cavaghan; Fiscal Year: 2000
    ..abstract_text> ..
  11. Mentored Patient-Oriented Research Career Development Aw
    James Stein; Fiscal Year: 2005
    ..Finally, Dr. Stein will determine if these medications impair postprandial clearance of triglyceride-containing lipoproteins by assessing lipid and lipoprotein responses to an oral fat load. ..
  12. HEALTH RESEARCH TRAINING PROGRAM
    Genevieve Ames; Fiscal Year: 2002
    ....
  13. Quality Threshold Analysis of Prostate Cancers
    Carlos Moreno; Fiscal Year: 2004
    ..Identification of genetic profiles associated with prostatic neoplasias that are more likely to result in aggressive disease may lead to improved management of prostate cancer patients. ..
  14. STATISTICAL SOFTWARE FOR SCALE SPACE SMOOTHING
    MAXIMILLIAN KARLOVITZ; Fiscal Year: 2000
    ..The commercial potential is strengthened by making the software widely and easily available via the Internet. ..
  15. BIODEMOGRAPHIC ANALYSIS OF AGING TRAJECTORIES
    Shiro Horiuchi; Fiscal Year: 2002
    ....
  16. Statistical Methods for the Analysis of Functional Genomic Data
    Debashis Ghosh; Fiscal Year: 2008
    ..unreadable] 5. Dissemination of these results in user-friendly statistical software. ..
  17. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2004
    ..Applications to real medical studies will be provided. The research results will be disseminated to practicing statisticians and medical investigators via publications, lectures and software distributions. ..
  18. STATISTICAL ISSUES IN AIDS RESEARCH
    Thomas Fleming; Fiscal Year: 2008
    ..Research into optimal designs of Phase HE "Intermediate Trials" of candidate HIV vaccines will also be continued. ..
  19. Effects of Aging on Executive Processes
    Timothy Salthouse; Fiscal Year: 2006
    ..e., specific to individual variables or common to many variables) at which age-related influences operate on executive process variables. ..
  20. Three-Class ROC Analysis for Task-Based Medical Image Quality Assessment
    Xin He; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. HIV PREVENTION TRIALS NETWORK LEADERSHIP GROUP
    Thomas Fleming; Fiscal Year: 2005
    ..abstract_text> ..
  22. American Indian MS to PHD Nursing Science Bridge-Phase 2
    SUSAN HENLY; Fiscal Year: 2006
    ..The project evaluation plan is a refinement of the Phase 1 plan designed to efficiently obtain maximum information about the structure, process, and outcomes of the project. ..
  23. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  24. PERCEPTUAL MODEL FOR WORKSTATION DISPLAY OPTIMIZATION
    Dev Chakraborty; Fiscal Year: 2002
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
  25. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  26. PERCEPTUAL MODEL FOR WORKSTATION DISPLAY OPTIMIZATION
    Dev Chakraborty; Fiscal Year: 2003
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
  27. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  28. Mechanisms Linking Hostility and Smoking
    Christopher Kahler; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. STRUCTURAL ORGANIZATION AND PROTEOMICS OF TB
    Thomas Terwilliger; Fiscal Year: 2005
    ..The structural and functional information obtained in this project is to be placed in the public domain by timely deposition in publicly available databases. ..
  30. Clinic-based Intervention to Improve Medication Adherence to Reduce CVD Risks
    James Christian; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Although the proposed study is not a randomized trial, it is thought that sufficient evidence could be generated that would result in FDA approval of an lFE such as Omegaven. ..
  32. In silico genome scan with high-throughput addiction related phenotypes in mice
    Edwin van den Oord; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. College Facilitation for Alcohol Problems
    William Zywiak; Fiscal Year: 2009
    ..The proposed study will be one of the first to examine the efficacy of this many contacts spread out over this long a period in a college sample. ..
  34. Protective Influence of Residential Learning Communities
    SEAN MCCABE; Fiscal Year: 2006
    ..At each measurement point, participants will complete a set of measures that assess substance use behaviors and constructs addressed by RLCs. ..
  35. Nonmedical Prescription Drug Use among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ..Findings from this research will have important implications for the understanding of the epidemiology, prevention and treatment of prescription drug abuse. ..
  36. MULTIMEDIA SMOKING CESSATION FOR ALCOHOLIC CLIENTS
    Stephen Butler; Fiscal Year: 2002
    ..If a computerized, affordable smoking cessation program can be shown, in field trials, to have demonstrable efficacy, the commercial potential can be extraordinary. ..
  37. Bayesian methods for analyzing genetic diversity
    KENT HOLSINGER; Fiscal Year: 2006
    ..Moreover, we develop refinements to existing user-friendly software implementing the methods we develop and make the software and the associated source code freely available under the GNU General Public license. ..
  38. Decoupling of Principal Renal Autoregulatory Mechanisms
    Ki Chon; Fiscal Year: 2005
    ..By exercising this model, as described under Specific Aim (5), we plan to begin understanding the underlying reasons for the changes observed in autoregulation under pathological conditions. ..
  39. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2009
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..
  40. Development automated assay-regulators insulin synthesis
    Patrick McDonough; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. METHADONE, BUPRENORPHINE AND FETAL DEVELOPMENT
    Lauren Jansson; Fiscal Year: 2004
    ..Upon completing the 5-year funding period, Dr. Jansson plans to have written an RO1 grant application to pursue research ideas identified during KO8 funding. ..
  42. IRSG STUDIES OF ALVEOLAR RHABDOMYOSARCOMA GENE FUSIONS
    FREDERIC BARR; Fiscal Year: 2005
    ..These studies will provide a definitive analysis of the occurrence and clinical significance of these genetic alterations in ARMS, and will ultimately impact on the future design of clinical protocols for the treatment of ARMS patients. ..
  43. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
    ....
  44. Treatment Utilization for Alcohol-Related Problems
    Li Tzy Wu; Fiscal Year: 2002
    ....
  45. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2003
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  46. NEUROIMAGING OF HIV AND COMORBID DISORDERS
    Lance Bauer; Fiscal Year: 2003
    ..An analysis of change scores across groups will permit a formal test of the effects of antiviral treatment on neurophysiological status. ..
  47. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
    ..abstract_text> ..
  48. SOY PROTEIN +/- ISOFLAVONOIDS AND PLASMA LIPIDS
    Alice Lichtenstein; Fiscal Year: 2002
    ..The results of these studies, whether positive or negative, should contribute to the data base on which to formulate more specific public health recommendations with respect to decreasing risk of developing CHD. ..
  49. A PROSPECTIVE STUDY OF RISK OF MORTALITY AFTER SCI
    James Krause; Fiscal Year: 2002
    ..Risk profiles will be generated to identify individuals at greatest risk for early mortality. Separate analyses and risk profiles will be generated based on injury severity, gender and race/ethnicity. ..
  50. Meta-Analysis of Interventions to Increase Exercise/Physical Acivity
    Vicki Conn; Fiscal Year: 2009
    ..The compelling importance and broad scope of this work make funding necessary to achieve these important aims. ..
  51. A High Throughput Imaging Assay for Hepatic Lipid Droplet Formation
    Patrick McDonough; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Early-Stage Breast Cancer Treatment Decisions by Women with Physical Disabilities
    Lisa Iezzoni; Fiscal Year: 2007
    ..Our findings will help begin educating patients and physicians and could perhaps improve breast cancer care for women with physical disabilities. [unreadable] [unreadable] [unreadable]..
  53. Effects of Depression on Short-Term Recovery from MI
    Kenneth Freedland; Fiscal Year: 2007
    ..The results will clarify the early course of post-MI depression and the mechanisms linking depression to cardiac events, and they will inform efforts to develop more efficacious treatments. ..
  54. Epidemiology of Recurrent Aphthous Stomatitis
    Lorena Baccaglini; Fiscal Year: 2007
    ..Understanding the cause of canker sores can lead to better treatments for patients affected by this condition. [unreadable] [unreadable] [unreadable]..
  55. High Throughput Imaging Assay for Beta-Catenin
    Patrick McDonough; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. DYNAMIC GROWTH & CHANGE IN ADULT INTELLECTUAL ABILITIES
    John McArdle; Fiscal Year: 2004
    ..abstract_text> ..
  57. MRI of Brain Function and Receptors in Cocaine Addiction
    Craig Ferris; Fiscal Year: 2005
    ..With this repeated 'in vivo autoradiography,' it is possible to correlate changes in cocaine associated brain activity with discrete changes in NT binding in the mesocorticolimbic system. ..
  58. A Randomized Trial of Home Self-Efficacy Enhancement
    Anthony Jerant; Fiscal Year: 2007
    ..The findings will help policymakers, payers, and providers identify which interventions to implement. ..
  59. Project CARE(Cocaine Abuse in the Rural Environment)
    FONDA EYLER; Fiscal Year: 2007
    ..abstract_text> ..
  60. CCBAR Workshop 2006-2007
    STACY LINDAU; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. Biometrical Modeling of Fertility Using the NLSY
    JOSEPH RODGERS; Fiscal Year: 2006
    ..Potential moderators/mediators include education, family structure, and quality of the family environment. ..
  62. STRUCTURE, PROCESS AND OUTCOMES IN THE PACE PROGRAM
    Dana Mukamel; Fiscal Year: 2003
    ..The knowledge gained from this study would have direct bearing on efforts to improve care in PACE programs, as well as implications for other programs serving frail, non-institutionalized elderly. ..
  63. Pittsburgh Mind-Body Center-II
    Karen Matthews; Fiscal Year: 2008
    ..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..