sensitivity and specificity

Summary

Summary: Measures for assessing the results of diagnostic and screening tests. Sensitivity represents the proportion of truly diseased persons in a screened population who are identified as being diseased by the test. It is a measure of the probability of correctly diagnosing a condition. Specificity is the proportion of truly nondiseased persons who are so identified by the screening test. It is a measure of the probability of correctly identifying a nondiseased person. (From Last, Dictionary of Epidemiology, 2d ed)

Top Publications

  1. ncbi Basic local alignment search tool
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894
    J Mol Biol 215:403-10. 1990
  2. pmc Measuring inconsistency in meta-analyses
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR
    BMJ 327:557-60. 2003
  3. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  4. pmc Accurate whole human genome sequencing using reversible terminator chemistry
    David R Bentley
    Illumina Cambridge Ltd Formerly Solexa Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK
    Nature 456:53-9. 2008
  5. ncbi Improved prediction of signal peptides: SignalP 3.0
    Jannick Dyrløv Bendtsen
    Center for Biological Sequence Analysis, BioCentrum DTU, Building 208, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Mol Biol 340:783-95. 2004
  6. pmc Serum microRNAs are promising novel biomarkers
    Shlomit Gilad
    Rosetta Genomics Ltd, Rehovot, Israel
    PLoS ONE 3:e3148. 2008
  7. pmc Loop-mediated isothermal amplification of DNA
    T Notomi
    Eiken Chemical Co Ltd, 1381 3 Shimoishigami, Ohtawara, Tochigi 324 0036, Japan, Department of Biochemistry and Molecular Biology, The University of Tokyo, Graduate School of Medicine, Bunkyo ku, Tokyo 113 0033, Japan
    Nucleic Acids Res 28:E63. 2000
  8. pmc Genome sequencing in microfabricated high-density picolitre reactors
    Marcel Margulies
    454 Life Sciences Corp, 20 Commercial Street, Branford, Connecticut 06405, USA
    Nature 437:376-80. 2005
  9. ncbi T-Coffee: A novel method for fast and accurate multiple sequence alignment
    C Notredame
    National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    J Mol Biol 302:205-17. 2000
  10. ncbi The validity of the Hospital Anxiety and Depression Scale. An updated literature review
    Ingvar Bjelland
    Department of Public Health and Primary Health Care, Section for Preventive Medicine, Haukeland Hospital, Armauer Hansen Building, University of Bergen, N 5021, Bergen, Norway
    J Psychosom Res 52:69-77. 2002

Detail Information

Publications418 found, 100 shown here

  1. ncbi Basic local alignment search tool
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894
    J Mol Biol 215:403-10. 1990
    ..In addition to its flexibility and tractability to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity...
  2. pmc Measuring inconsistency in meta-analyses
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR
    BMJ 327:557-60. 2003
  3. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  4. pmc Accurate whole human genome sequencing using reversible terminator chemistry
    David R Bentley
    Illumina Cambridge Ltd Formerly Solexa Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK
    Nature 456:53-9. 2008
    ..Our approach is effective for accurate, rapid and economical whole-genome re-sequencing and many other biomedical applications...
  5. ncbi Improved prediction of signal peptides: SignalP 3.0
    Jannick Dyrløv Bendtsen
    Center for Biological Sequence Analysis, BioCentrum DTU, Building 208, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Mol Biol 340:783-95. 2004
    ..The new method has been benchmarked against other available methods. Predictions can be made at the publicly available web server..
  6. pmc Serum microRNAs are promising novel biomarkers
    Shlomit Gilad
    Rosetta Genomics Ltd, Rehovot, Israel
    PLoS ONE 3:e3148. 2008
    ..Here we show that microRNAs, a family of small non-coding regulatory RNAs involved in human development and pathology, are present in bodily fluids and represent new effective biomarkers...
  7. pmc Loop-mediated isothermal amplification of DNA
    T Notomi
    Eiken Chemical Co Ltd, 1381 3 Shimoishigami, Ohtawara, Tochigi 324 0036, Japan, Department of Biochemistry and Molecular Biology, The University of Tokyo, Graduate School of Medicine, Bunkyo ku, Tokyo 113 0033, Japan
    Nucleic Acids Res 28:E63. 2000
    ..Because LAMP recognizes the target by six distinct sequences initially and by four distinct sequences afterwards, it is expected to amplify the target sequence with high selectivity...
  8. pmc Genome sequencing in microfabricated high-density picolitre reactors
    Marcel Margulies
    454 Life Sciences Corp, 20 Commercial Street, Branford, Connecticut 06405, USA
    Nature 437:376-80. 2005
    ..Here we show the utility, throughput, accuracy and robustness of this system by shotgun sequencing and de novo assembly of the Mycoplasma genitalium genome with 96% coverage at 99.96% accuracy in one run of the machine...
  9. ncbi T-Coffee: A novel method for fast and accurate multiple sequence alignment
    C Notredame
    National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    J Mol Biol 302:205-17. 2000
    ..The improvement, especially clear with the more difficult test cases, is always visible, regardless of the phylogenetic spread of the sequences in the tests...
  10. ncbi The validity of the Hospital Anxiety and Depression Scale. An updated literature review
    Ingvar Bjelland
    Department of Public Health and Primary Health Care, Section for Preventive Medicine, Haukeland Hospital, Armauer Hansen Building, University of Bergen, N 5021, Bergen, Norway
    J Psychosom Res 52:69-77. 2002
    ..To review the literature of the validity of the Hospital Anxiety and Depression Scale (HADS)...
  11. ncbi Quantification of coronary artery calcium using ultrafast computed tomography
    A S Agatston
    Mount Sinai Medical Center, Miami Beach, Florida 33140
    J Am Coll Cardiol 15:827-32. 1990
    ..Ultrafast computed tomography is an excellent tool for detecting and quantifying coronary artery calcium...
  12. pmc A new statistical method for haplotype reconstruction from population data
    M Stephens
    Department of Statistics, University of Oxford
    Am J Hum Genet 68:978-89. 2001
    ..Furthermore, our algorithm performs well in absolute terms, suggesting that reconstructing haplotypes experimentally or by genotyping additional family members may be an inefficient use of resources...
  13. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  14. pmc Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    Lancet 377:1495-505. 2011
    ..Cepheid, Sunnyvale, CA, USA) can detect tuberculosis and its multidrug-resistant form with very high sensitivity and specificity in controlled studies, but no performance data exist from district and subdistrict health facilities in ..
  15. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
    ....
  16. pmc Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire
    Jean T Coulibaly
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1384. 2011
    ..We assessed the accuracy of a commercially available CCA cassette test (designated CCA-A) and an experimental formulation (CCA-B) for S. mansoni diagnosis...
  17. pmc Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    Leslie M Shaw
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 65:403-13. 2009
    ..Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects...
  18. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
    ..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...
  19. pmc Quantification of rare allelic variants from pooled genomic DNA
    Todd E Druley
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Methods 6:263-5. 2009
    ..Our base-calling algorithm, SNPSeeker, derived from large deviation theory, detected single-nucleotide polymorphisms present at frequencies below the raw error rate of the sequencing platform...
  20. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
    ..These ChIPSeq data also have high sensitivity and specificity [ROC (receiver operator characteristic) area >/= 0...
  21. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
    ..Application of this index may decrease the need for staging liver biopsy specimens among CHC patients...
  22. pmc Systematic reviews of diagnostic test accuracy
    Mariska M G Leeflang
    Dutch Cochrane Centre and Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Intern Med 149:889-97. 2008
    ..Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research...
  23. pmc Targeted capture and massively parallel sequencing of 12 human exomes
    Sarah B Ng
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Nature 461:272-6. 2009
    ..This strategy may be extendable to diseases with more complex genetics through larger sample sizes and appropriate weighting of non-synonymous variants by predicted functional impact...
  24. pmc Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
    ..In this study, we focused on schoolchildren on Unguja Island, Zanzibar, an area where anthelminthic drugs have been repeatedly administered over the past decade...
  25. pmc SSAHA: a fast search method for large DNA databases
    Z Ning
    Informatics Division, The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genome Res 11:1725-9. 2001
    ..The SSAHA algorithm is used for high-throughput single nucleotide polymorphism (SNP) detection and very large scale sequence assembly. Also, it provides Web-based sequence search facilities for Ensembl projects...
  26. pmc Detection of cancer with serum miRNAs on an oligonucleotide microarray
    Michael J Lodes
    CombiMatrix Corporation, Mukilteo, WA, USA
    PLoS ONE 4:e6229. 2009
    ..In addition, we are able to use these expression patterns to correctly discriminate between normal and cancer patient samples...
  27. ncbi Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    Wolfgang Huber
    Department of Molecular Genome Analysis, German Cancer Research Center, INF 280, Heidelberg, 69120, Germany
    Bioinformatics 18:S96-104. 2002
    ..We demonstrate our approach on data sets from different experimental platforms, including two-colour cDNA arrays and a series of Affymetrix oligonucleotide arrays...
  28. ncbi Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
    S A Bustin
    Academic Department of Surgery, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London E1 1BB, UK
    J Mol Endocrinol 25:169-93. 2000
    ..It illustrates the usefulness of these assays by demonstrating the significantly different levels of transcription between individuals of the housekeeping gene family, glyceraldehyde-3-phosphate-dehydrogenase (GAPDH)...
  29. pmc Meta-DiSc: a software for meta-analysis of test accuracy data
    Javier Zamora
    Clinical Biostatistics Unit, Ramon y Cajal Hospital, Spain
    BMC Med Res Methodol 6:31. 2006
    ..In this article, we present Meta-DiSc, a Windows-based, user-friendly, freely available (for academic use) software that we have developed, piloted, and validated to perform diagnostic meta-analysis...
  30. ncbi The diagnostic odds ratio: a single indicator of test performance
    Afina S Glas
    Department of Clinical Epidemiology and Biostatistics, University of Amsterdam, Academic Medical Center, Post Office Box 22700, 100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 56:1129-35. 2003
    ..Several indicators of diagnostic performance have been proposed, such as sensitivity and specificity. Using paired indicators can be a disadvantage in comparing the performance of competing tests, ..
  31. pmc The global burden of typhoid fever
    John A Crump
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, MS A 38, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Bull World Health Organ 82:346-53. 2004
    ..To use new data to make a revised estimate of the global burden of typhoid fever, an accurate understanding of which is necessary to guide public health decisions for disease control and prevention efforts...
  32. pmc New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma
    Sarah Palmer
    HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    J Clin Microbiol 41:4531-6. 2003
    ....
  33. doi Stem cell transcriptome profiling via massive-scale mRNA sequencing
    Nicole Cloonan
    Expression Genomics Laboratory, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, Queensland, 4072, Australia
    Nat Methods 5:613-9. 2008
    ....
  34. doi Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis
    R Diel
    Dept of Pneumology, Medical School Hanover, Hanover, Germany
    Eur Respir J 37:88-99. 2011
    ..IGRAs may have a relative advantage over the TST in detecting LTBI and allow the exclusion of M. tuberculosis infection with higher reliability...
  35. ncbi Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire
    R L Spitzer
    Biometrics Research Department, New York State Psychiatric Institute, and Columbia University, New York 10032, USA
    JAMA 282:1737-44. 1999
    ..The Primary Care Evaluation of Mental Disorders (PRIME-MD) was developed as a screening instrument but its administration time has limited its clinical usefulness...
  36. ncbi Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems
    S A Bustin
    Academic Department of Surgery, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London E1 1BB, UK
    J Mol Endocrinol 29:23-39. 2002
    ....
  37. pmc Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening
    Janet Cox-Singh
    Malaria Research Centre, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Kuching, Sarawak, Malaysian Borneo
    Clin Infect Dis 46:165-71. 2008
    ..The objectives of the present study were to determine the geographic distribution of P. knowlesi malaria in the human population in Malaysia and to investigate 4 suspected fatal cases...
  38. pmc Comparing diagnostic accuracy of Kato-Katz, Koga agar plate, ether-concentration, and FLOTAC for Schistosoma mansoni and soil-transmitted helminths
    Dominik Glinz
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e754. 2010
    ..Accurate diagnosis is crucial for patient management, drug efficacy evaluations, and monitoring of large-scale community-based control programs...
  39. pmc Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Future Microbiol 6:1067-82. 2011
    ..Following endorsement by the WHO in 2010, we consider the next steps in the implementation of the assay and its potential impact in high burden settings...
  40. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  41. ncbi Time-dependent ROC curves for censored survival data and a diagnostic marker
    P J Heagerty
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 56:337-44. 2000
    ROC curves are a popular method for displaying sensitivity and specificity of a continuous diagnostic marker, X, for a binary disease variable, D...
  42. ncbi Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
    Johannes B Reitsma
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 58:982-90. 2005
    Studies of diagnostic accuracy most often report pairs of sensitivity and specificity. We demonstrate the advantage of using bivariate meta-regression models to analyze such data.
  43. pmc Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections
    Sophie Alcon
    Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Clin Microbiol 40:376-81. 2002
    ..Furthermore, NS1 circulation in the bloodstream of patients during the clinical phase of the disease suggests a contribution of the nonstructural protein to dengue virus pathogenesis...
  44. ncbi A global test for groups of genes: testing association with a clinical outcome
    Jelle J Goeman
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Bioinformatics 20:93-9. 2004
    ..Groups of genes may be any size from a single gene to all genes on the chip (e.g. known pathways, specific areas of the genome or clusters from a cluster analysis)...
  45. pmc Bead-based multiplex genotyping of human papillomaviruses
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Clin Microbiol 44:504-12. 2006
    ..922) but also indicated a higher sensitivity of MPG. In conclusion, MPG appears to be highly suitable for large-scale epidemiological studies and vaccination trials as well as for routine diagnostic purposes...
  46. ncbi Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques
    R de la Rua-Domenech
    Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
    Res Vet Sci 81:190-210. 2006
    ..The key measure of diagnostic test accuracy is the relationship between sensitivity and specificity, which determines the false-positive and false-negative proportions...
  47. pmc Update on rapid diagnostic testing for malaria
    Clinton K Murray
    Infectious Disease Service, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Clin Microbiol Rev 21:97-110. 2008
    ..This review highlights RDTs, including challenges in assessing their performance, internationally available RDTs, their effectiveness in various health care settings, and the selection of RDTs for different health care systems...
  48. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
    ..The PCR prevalence was then compared against other measures of transmission intensity collected in the same area...
  49. doi Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis
    Roland Diel
    Department of Pulmonary Medicine, Hannover Medical School MHH, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 137:952-68. 2010
    ..This metaanalysis critically appraises studies investigating sensitivity and specificity of the commercial T-Spot...
  50. ncbi MethPrimer: designing primers for methylation PCRs
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA 94121, USA
    Bioinformatics 18:1427-31. 2002
    ..Therefore, the present study was designed to develop a program for such applications...
  51. ncbi Overview of the European and North American studies on HPV testing in primary cervical cancer screening
    Jack Cuzick
    Cancer Research UK, Wolfson Institute of Preventive Medicine, London
    Int J Cancer 119:1095-101. 2006
    ..More than 60,000 women were included. The sensitivity and specificity of HPV testing were compared with routine cytology, both overall and for ages <35, 35-49 and 50+...
  52. ncbi A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations
    C M Rutter
    Group Health Cooperative, Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA
    Stat Med 20:2865-84. 2001
    ..we describe a hierarchical regression model for meta-analysis of studies reporting estimates of test sensitivity and specificity. The model allows more between- and within-study variability than fixed-effect approaches, by allowing ..
  53. ncbi Autoantibody signatures in prostate cancer
    Xiaoju Wang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    N Engl J Med 353:1224-35. 2005
    ..New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer...
  54. pmc Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam
    Judith Kahama-Maro
    City Medical Office of Health, Dar es Salaam City Council, P O Box 63320, Dar es Salaam, United Republic of Tanzania
    Malar J 10:332. 2011
    ....
  55. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  56. pmc Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology
    Danica Helb
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry, New Jersey, Newark, New Jersey 07103, USA
    J Clin Microbiol 48:229-37. 2010
    ..2%) susceptible cases. Specificity rose to 100% after correcting for a conventional susceptibility test error. In conclusion, this highly sensitive and simple-to-use system can detect M. tuberculosis directly from sputum in less than 2 h...
  57. doi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012
    ..The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening...
  58. ncbi Quantitative detection of increasing HIV type 1 antibodies after seroconversion: a simple assay for detecting recent HIV infection and estimating incidence
    Bharat S Parekh
    Division of AIDS, STD, TB Laboratory Research, and Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 18:295-307. 2002
    ..0 OD-n and a seroconversion period of 160 days offered the best combination of sensitivity and specificity for classifying incident or long-term infections...
  59. ncbi PCR diagnosis and characterization of Leishmania in local and imported clinical samples
    Gabriele Schonian
    Institute of Microbiology and Hygiene, Humboldt University, Charite, Berlin, Germany
    Diagn Microbiol Infect Dis 47:349-58. 2003
    ..113 cases (69.7%) were positive by PCR and species identification was possible in 110 samples. Leishmania DNA was also amplified and identified at the species level from archived non-stained and Giemsa stained microscope slides...
  60. pmc Statistics review 13: receiver operating characteristic curves
    Viv Bewick
    School of Computing, Mathematical and Information Sciences, University of Brighton, Brighton, UK
    Crit Care 8:508-12. 2004
    ..The sensitivity, specificity and likelihood ratio of a test are discussed. The uses of the receiver operating characteristic curve and the area under the curve are explained...
  61. ncbi Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    J D England
    Neurology 64:199-207. 2005
    ..The inclusion of this formalized case definition in clinical and epidemiologic research studies will ensure greater consistency of case selection...
  62. ncbi Prediction error estimation: a comparison of resampling methods
    Annette M Molinaro
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD 20852, USA
    Bioinformatics 21:3301-7. 2005
    ..With a focus on prediction assessment, we compare several methods for estimating the 'true' prediction error of a prediction model in the presence of feature selection...
  63. pmc Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens
    W Allan Nix
    Polio and Picornavirus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:2698-704. 2006
    ....
  64. ncbi Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review
    Karen R Steingart
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Lancet Infect Dis 6:664-74. 2006
    ..Operational studies are needed to determine whether the increased sensitivity provided by processing methods is sufficient to offset their increased cost, complexity, and potential biohazards, and to examine their feasibility...
  65. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
    ....
  66. pmc False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene
    Ousmane A Koita
    Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 86:194-8. 2012
    ..These findings suggest that the use of HRP2-based RDTs should be reconsidered...
  67. ncbi New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes
    R S Janssen
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 280:42-8. 1998
    ..Differentiating individuals with early human immunodeficiency virus 1 (HIV-1) infection from those infected for longer periods is difficult but important for estimating HIV incidence and for purposes of clinical care and prevention...
  68. ncbi Validation and application of verbal autopsies in a rural area of South Africa
    K Kahn
    Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 5:824-31. 2000
    ..To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in the Agincourt subdistrict of rural South Africa...
  69. ncbi Breast disease: clinical application of US elastography for diagnosis
    Ako Itoh
    Department of Breast and Endocrine Surgery, Tsukuba University Hospital, University of Tsukuba, Tsukuba, Japan
    Radiology 239:341-50. 2006
    ....
  70. ncbi The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard
    L B Ochola
    Centre for Geographic Medicine Research, KEMRI, Kilifi, Kenya
    Lancet Infect Dis 6:582-8. 2006
    ..Microscopy still remains more reliable in detecting non-falciparum infections...
  71. doi Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
    Brian T Wilhelm
    Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nature 453:1239-43. 2008
    ..Splicing efficiency was largely coordinated with transcript levels, and increased transcription led to increased splicing in test genes. Hundreds of introns showed such regulated splicing during cellular proliferation or differentiation...
  72. pmc Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies
    Haileyesus Getahun
    World Health Organization, Geneva, Switzerland
    PLoS Med 8:e1000391. 2011
    ..We conducted an individual participant data meta-analysis of primary studies, aiming to identify a sensitive TB screening rule...
  73. pmc High throughput multiplex PCR and probe-based detection with Luminex beads for seven intestinal parasites
    Mami Taniuchi
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA22908, USA
    Am J Trop Med Hyg 84:332-7. 2011
    ..the parent multiplex real-time PCR assays, this multiplex PCR-bead assay afforded between 83% and 100% sensitivity and specificity on a total of 319 clinical specimens...
  74. pmc Highly sensitive and specific detection of rare variants in mixed viral populations from massively parallel sequence data
    Alexander R Macalalad
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    PLoS Comput Biol 8:e1002417. 2012
    ..deep sequence data sets is the ability to distinguish biological variants from process errors with high sensitivity and specificity. To address this challenge, we describe V-Phaser, an algorithm able to recognize rare biological ..
  75. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  76. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  77. ncbi A new rating scale for age-related white matter changes applicable to MRI and CT
    L O Wahlund
    Department of Clinical Neuroscience, Neurotec, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden
    Stroke 32:1318-22. 2001
    ..We have developed and evaluated a new scale and studied ARWMC in a large number of patients examined with both MRI and CT...
  78. ncbi The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass
    Richard G Moore
    Women and Infants Hospital, Brown University, Providence, RI 02925, USA
    Gynecol Oncol 108:402-8. 2008
    ..Because elevated CA125 levels occur in many benign gynecologic conditions, we set out to identify other novel biomarkers that would increase the sensitivity and specificity of CA125.
  79. pmc Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand
    PLoS ONE 5:e12485. 2010
    ....
  80. doi Sensitive and rapid detection of Schistosoma japonicum DNA by loop-mediated isothermal amplification (LAMP)
    J Xu
    Medical College of Soochow University, Suzhou, Jiangsu Province, People s Republic of China
    Int J Parasitol 40:327-31. 2010
    ..The established LAMP assay should provide a useful and practical tool for the routine diagnosis and therapeutic evaluation of human schistosomiasis...
  81. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
    ..The sensitivity and specificity of a test vary according to the level that is chosen as the cut-off point...
  82. ncbi Protein detection using proximity-dependent DNA ligation assays
    Simon Fredriksson
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE 75185 Uppsala, Sweden
    Nat Biotechnol 20:473-7. 2002
    ..This proximity ligation assay detects zeptomole (40 x 10(-21) mol) amounts of the cytokine platelet-derived growth factor (PDGF) without washes or separations, and the mechanism can be generalized to other forms of protein analysis...
  83. doi Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial
    Guglielmo Ronco
    Centre for Cancer Prevention, Turin, Italy
    Lancet Oncol 11:249-57. 2010
    ..We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing...
  84. pmc Accuracy of CT colonography for detection of large adenomas and cancers
    C Daniel Johnson
    Mayo Clinic Arizona, Scottsdale, AZ, USA
    N Engl J Med 359:1207-17. 2008
    ..Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as a screening tool in asymptomatic adults has not been well defined...
  85. pmc Towards high-throughput molecular detection of Plasmodium: new approaches and molecular markers
    Nicolas Steenkeste
    Institut Pasteur du Cambodge, Laboratoire d Epidemiologie Moleculaire, Phnom Penh, Cambodia
    Malar J 8:86. 2009
    ..But sensitive diagnosis tools enabling to deal with a large number of samples are needed. The molecular detection approach offers a much higher sensitivity, and the flexibility to be automated and upgraded...
  86. pmc A sensitive cardiac troponin T assay in stable coronary artery disease
    Torbjørn Omland
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway
    N Engl J Med 361:2538-47. 2009
    ..The distribution and determinants of very low circulating troponin T levels, as well as their association with cardiovascular events, in such patients are unknown...
  87. pmc Evaluation of urine CCA assays for detection of Schistosoma mansoni infection in Western Kenya
    Hillary L Shane
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 5:e951. 2011
    ..Our results suggest that urine-based assays for CCA may be valuable in screening for S. mansoni infections...
  88. pmc Detection of four Plasmodium species in blood from humans by 18S rRNA gene subunit-based and species-specific real-time PCR assays
    Mathieu Rougemont
    Institute of Microbiology, University Hospital of Lausanne, Switzerland
    J Clin Microbiol 42:5636-43. 2004
    ..This suggests a role of quantitative PCR for the monitoring of patients receiving antimalaria therapy...
  89. ncbi Strategies for containing an emerging influenza pandemic in Southeast Asia
    Neil M Ferguson
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 437:209-14. 2005
    ..Policy effectiveness depends critically on how quickly clinical cases are diagnosed and the speed with which antiviral drugs can be distributed...
  90. ncbi Facile means for quantifying microRNA expression by real-time PCR
    Rui Shi
    North Carolina State University, Raleigh, NC 27695 7247, USA
    Biotechniques 39:519-25. 2005
    ..This method also revealed miRNA tissue-specific expression patterns that cannot be resolved by Northern blot analysis and may therefore be widely useful for characterizing miRNA expression in plants as well as in animals...
  91. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ....
  92. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
    ..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
  93. ncbi Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis
    Dan Theodorescu
    Department of Molecular Physiology, Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA, USA
    Lancet Oncol 7:230-40. 2006
    ..We aimed to use mass spectrometry and bioinformatics to define and validate a cancer-specific proteomic pattern...
  94. pmc Malaria misdiagnosis in Uganda--implications for policy change
    Joan Nankabirwa
    Malaria Consortium, Africa Regional Office, Kampala, Uganda
    Malar J 8:66. 2009
    ..In this study, the policy implications of such recommendations are revisited...
  95. pmc Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria
    Elizabeth A Ashley
    Epicentre, Paris, France
    Malar J 8:241. 2009
    ..In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH)...
  96. pmc Diagnosis of visceral leishmaniasis
    Pankaj Srivastava
    Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Trans R Soc Trop Med Hyg 105:1-6. 2011
    ..A simple, rapid, non invasive, accurate and cost effective marker of active VL, which can be used in field conditions, is necessary to improve diagnosis of VL...
  97. pmc Applied genomics: data mining reveals species-specific malaria diagnostic targets more sensitive than 18S rRNA
    Allison Demas
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30602, USA
    J Clin Microbiol 49:2411-8. 2011
    ..vivax strains and 96 P. vivax clinical isolates from Venezuela, and we have verified a sensitivity and specificity of ∼100% for both targets compared with a nested 18S rRNA approach...
  98. pmc Performance assessment of the GenoType MTBDRsl test and DNA sequencing for detection of second-line and ethambutol drug resistance among patients infected with multidrug-resistant Mycobacterium tuberculosis
    Wei Lun Huang
    Reference Laboratory of Mycobacteriology, Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, Republic of China
    J Clin Microbiol 49:2502-8. 2011
    ..We recommend including new alleles consisting of the eis promoter and embB genes in molecular analysis. However, conventional DST is necessary to rule out false-negative results from molecular assays...
  99. pmc Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria
    Stephen E Schachterle
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Microbiol 49:3885-91. 2011
    ..falciparum parasite rate and parasite densities are highest. Real-time PCR is more sensitive and specific than RDT and microscopy in low-prevalence, low-parasite-density settings...
  100. pmc A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis
    Katherine Gass
    Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America
    PLoS Negl Trop Dis 6:e1479. 2012
    ..diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use...

Research Grants80

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  4. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  5. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The contractor is responsible for providing staff with the credentials required by CLIA. ..
  6. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Together these studies will significantly advance our understanding of the molecular regulation of pain receptor pathways, which may form the basis for future pain treatments. ..
  7. Lauren Endres; Fiscal Year: 2014
    ..Overall, these findings will form the basis of future studies into Abh8 regulation during the DDR. ..
  8. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..We therefore believe the proposed work has the potential to have a significant impact on the health care of Veterans. ..
  9. Jill M Wecht; Fiscal Year: 2014
    ....
  10. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..in Beagle Dog via Implantable Telemetry: This study has been awarded to the lab to determine the sensitivity and specificity of the conscious canine radio telemetry model for the evaluation of QT interval prolongation using six ..
  11. Cory Teuscher; Fiscal Year: 2014
    ....
  12. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  13. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..in Beagle Dog via Implantable Telemetry: This study has been awarded to the lab to determine the sensitivity and specificity of the conscious canine radio telemetry model for the evaluation of QT interval prolongation using six ..
  14. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  15. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..2. Evaluate the potential therapeutic effects of CST and its variants on insulin sensitivity and baroreflex sensitivity and heart rate variability in high fat diet-induced insulin resistant and in db/db diabetic mice. ..
  16. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..The results of this research may provide a better understanding of ways to prevent and/or treat diabetes and its cardiovascular complications for millions of Americans. ..
  17. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..A better understanding of factors involved in insulin resistance should enable development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
  18. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..This grant is also relevant for the ARRA in that it will immediately create 3 new professional jobs. ..
  19. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..abstract_text> ..
  20. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Three aims are proposed in this application to test these hypotheses and elucidate how SAMe affects signaling pathways that are important in hepatocarcinogenesis and development of alcoholic liver injury. ..
  21. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety. ..
  22. Roby Greenwald; Fiscal Year: 2016
    ..In addition, we will actively engage in a process of biomarker discovery and evaluation. ..
  23. JAMES RUSSELL SOWERS; Fiscal Year: 2015
    ..A better understanding of factors involved in insulin resistance should help in the development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
  24. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans. ..
  25. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..The results of this study will aid in the development of evidence-based guidelines for the treatment of Alaska Native infants diagnosed with CPT1A deficiency by newborn screening. ..
  26. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ....
  27. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ....
  28. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  29. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..Results of these studies may yield new information for setting guidelines for pregnant and lactating women that may protect offspring from enhanced susceptibility to these metabolic diseases. ..
  30. Mark W Chapleau; Fiscal Year: 2015
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  31. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..The current study goals are investigating the effect of the mutation on metabolism of glucose and insulin secretion and function in patients with this mutation. ..
  32. David A Bernlohr; Fiscal Year: 2014
    ..If the hypothesis is proven to be correct, the study would be immediately translatable to human biology and afford a new view of how type 2 diabetes may be combated. ..
  33. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ....
  34. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    ..The studies may also provide the basis for further analysis of identified targets (cis- and trans-elements) that could ultimately allow us to increase the chemoprotective capacity of cells. ..
  35. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..These studies should lead to an improved understanding of the basic causes of Type 2 diabetes mellitus and hold the potential for new therapeutic modalities. ..
  36. CYNTHIA T MCEVOY; Fiscal Year: 2016
    ..End of Abstract) ..
  37. Melissa A Rosenkranz; Fiscal Year: 2014
    ..abstract_text> ..
  38. Rinn Song; Fiscal Year: 2016
    ....
  39. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..To establish clinical sensitivity and specificity, the miRNA results will be correlated with colonoscopy, FOBT and pathology data...
  40. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
  41. Haifei Shi; Fiscal Year: 2015
    ....
  42. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ....
  43. UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015
    ..Pajvani will need in order to become an independent translational medical researcher and a productive member of the academic medical community. ..
  44. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ....
  45. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Other applications for this technology are expected to be part of the GEI, the National Children's Study (NCS), in workplace assessments of occupational exposure, hospitals, or other medical or research settings. ..
  46. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..ASS in serum was developed, and sufficient data were obtained demonstrating the greater biomarker sensitivity and specificity in experimental models of liver injury compared to ALT/AST...
  47. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ....
  48. ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2014
    ..The work is clinically relevant because it will resolve questions about iron in the formal pathogenesis and natural history of FRDA, and the potential value of iron chelation. ..
  49. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ....
  50. W Timothy Garvey; Fiscal Year: 2016
    ..These data will predictably identify new diagnostic biomarkers for insulin resistance and T2DM, and advance our understanding of molecular mechanisms underlying human insulin resistance. ..
  51. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..pure chemoreflex-mediated sleep apnea, to adjust the spectrogram's parameters that allow the best sensitivity and specificity for detecting chemoreflex influences on sleep respiration...
  52. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..The contributions of alterations in the production of gastrointestinal and adipocyte hormones, changes of bile acids and intestinal microbial composition, as well as mitochondrial function will be assessed. ..
  53. Beverley Greenwood-Van Meerveld; Fiscal Year: 2016
    ..Moreover, we will examine whether rats exposed to ELS show altered behavioral responses to chronic stress in adulthood compared to age-matched controls ..
  54. CHARLES RICHARD STEELE; Fiscal Year: 2016
    ....
  55. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  56. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..Moreover, we plan to screen number of families with inherited CAD, metabolic syndrome, and osteoporosis for mutations within this gene to identify novel mutations and to investigate their disease causing mechanisms. ..
  57. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..The SHIP study will provide insight into the pathophysiology of glucose intolerance, and the findings will have implications not only for diabetes prevention but also for other diseases that focus on sex hormones as mediators. ..
  58. Howard B Lieberman; Fiscal Year: 2016
    ....
  59. Y S Prakash; Fiscal Year: 2016
    ..By establishing the role of neurotrophins in airway narrowing with or without inflammation, the proposed studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  60. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
    ..Receiver operating characteristic curves will be used to compare sensitivity and specificity for bilirubin-induced auditory toxicity of unbound bilirubin, bilirubin:albumin ratio, and total serum ..
  61. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ....
  62. Cornelia M Weyand; Fiscal Year: 2016
    ..The studies will include vaccinating RA patients with an influenza vaccine to test whether they can build sufficient T cells to be protected from infection. ..
  63. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..Improved treatment options, in this case the use of sodium nitrite for the management of COPD exacerbations precipitated by PA infection are needed to reduce mortality and morbidity. ..
  64. Advanced Center for Latino and MH Systems Research
    Margarita Alegria; Fiscal Year: 2009
    ..drug abuse and alcohol abuse;Aim 2: Use data from an epidemiological survey to assess the potential sensitivity and specificity of the clinical determinations identified in Aim1 in detecting the underlying diagnosis...
  65. JYOTSNA S SHAH; Fiscal Year: 2014
    ..5) Results can be obtained in one hour or less would be valuable. (6) Provides parasite morphology as the Giemsa stained smear. (7) Easy to perform. (8) Low Cost. ..
  66. Tb-FISH (Fluorescent in Situ Hybridization) Assay for Direct Detection of M. tube
    JYOTSNA S SHAH; Fiscal Year: 2010
    ..Unfortunately the acid-fast smear lacks both sensitivity and specificity. We demonstrated in Phase I that the MTB-FISH assay sensitivity in pure culture is between 1000 to 10,..
  67. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ....
  68. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ....
  69. Novel Use of Confocal Microscopy on Cultured Porcine Corneas for Pre-Clinical Tes
    Michelle Piehl; Fiscal Year: 2011
    ..This would reduce overall product development cost and human test subject pain and distress while promoting robust product safety for public health. ..
  70. TB- FISH Assay for Direct Detection of M. tuberculosis in unprocessed sputum
    Jyotsna Shah; Fiscal Year: 2007
    ..Unfortunately the acid- fast smear prepared form unprocessed sputum lacks both sensitivity and specificity. TB-FISH (Fluorescent In Situ Hybridization) assay for direct detection of MTB in unprocessed sputum, ..
  71. GABRIELLE HELENA SAUNDERS; Fiscal Year: 2014
    ..Results will contribute to the development of evidence-based intervention approaches for blast-exposed veterans with reported functional hearing difficulties and normal/near-normal auditory sensitivity. ..
  72. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris C Shaw; Fiscal Year: 2010
    ....
  73. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris Shaw; Fiscal Year: 2007
    ....
  74. Low-cost Large-area High-Sensitivity X-ray Panel Detector for Digital Mammography
    NEAL EUGENE HARTSOUGH; Fiscal Year: 2010
    ..Mammography will benefit due to the improved spatial resolution and reduced cost from this unique combination of detector material and readout. ..
  75. EXERCISE AS A MEANS OF ENHANCING IMMUNITY IN THE AGED
    Jeffrey Woods; Fiscal Year: 2001
    ....
  76. DNA methylation markers for cervical intraepithelial neoplasia III
    Qinghua Feng; Fiscal Year: 2009
    ..We hypothesize that DNA methylation markers can be used to detect CIN-3/CIS with higher sensitivity and specificity than cytology and HR-HPV tests, and will have clinical utility in reducing colposcopy referral rate for ..
  77. Development of a FISH-Based HPV-Associated Cancer Detection Test
    Jane Houldsworth; Fiscal Year: 2009
    ..Phase II;Specific Aim 2: Optimization of the FHACT in 1,000 cervical cytology specimens. The sensitivity and specificity of the FHACT will be determined for the entire dataset of 1,000 cervical cytology specimens and ..
  78. Glutathione reductase and tumor sensitivity to radiation
    Xiangming Guan; Fiscal Year: 2003
    ..The long-term objective is to develop a novel approach to increase cancer sensitivity to radiation. ..
  79. PAIN AND BETA-ENDORPHIN RESPONSES IN MEN AND WOMEN
    David Sheps; Fiscal Year: 2001
    ..Finally, naloxone will be introduced to determine if thee effects are mediated by beta-endorphin. ..