multivariate analysis


Summary: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

Top Publications

  1. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  2. ncbi Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India
    D Filmer
    Development Research Group, World Bank, 1818 H Street NW, Washington, DC 20433, USA
    Demography 38:115-32. 2001
  3. doi adegenet: a R package for the multivariate analysis of genetic markers
    Thibaut Jombart
    Universite de Lyon, Universite Lyon 1, CNRS, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, France
    Bioinformatics 24:1403-5. 2008
  4. doi Stromal gene signatures in large-B-cell lymphomas
    G Lenz
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 359:2313-23. 2008
  5. pmc Information-based functional brain mapping
    Nikolaus Kriegeskorte
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 1D80B, 10 Center Drive MSC 1148, Bethesda, MD 20892 1148, USA
    Proc Natl Acad Sci U S A 103:3863-8. 2006
  6. pmc Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus
    Wen Sheng Yue
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 10:113. 2011
  7. ncbi The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    E M Antman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 284:835-42. 2000
  8. ncbi Association of hypoadiponectinemia with coronary artery disease in men
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 23:85-9. 2003
  9. ncbi Major causes of death among men and women in China
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    N Engl J Med 353:1124-34. 2005
  10. ncbi Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials
    Richard J Sylvester
    EORTC Data Center, Brussels, Belgium
    Eur Urol 49:466-5; discussion 475-7. 2006

Detail Information

Publications396 found, 100 shown here

  1. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  2. ncbi Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India
    D Filmer
    Development Research Group, World Bank, 1818 H Street NW, Washington, DC 20433, USA
    Demography 38:115-32. 2001
    ..On average a "rich" child is 31 percentage points more likely to be enrolled than a "poor" child, but this gap varies from only 4.6 percentage points in Kerala to 38.2 in Uttar Pradesh and 42.6 in Bihar...
  3. doi adegenet: a R package for the multivariate analysis of genetic markers
    Thibaut Jombart
    Universite de Lyon, Universite Lyon 1, CNRS, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, France
    Bioinformatics 24:1403-5. 2008
    The package adegenet for the R software is dedicated to the multivariate analysis of genetic markers...
  4. doi Stromal gene signatures in large-B-cell lymphomas
    G Lenz
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 359:2313-23. 2008
    ..Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear...
  5. pmc Information-based functional brain mapping
    Nikolaus Kriegeskorte
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 1D80B, 10 Center Drive MSC 1148, Bethesda, MD 20892 1148, USA
    Proc Natl Acad Sci U S A 103:3863-8. 2006
  6. pmc Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus
    Wen Sheng Yue
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 10:113. 2011
    ..Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown...
  7. ncbi The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    E M Antman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 284:835-42. 2000
    ..Patients with unstable angina/non-ST-segment elevation myocardial infarction (MI) (UA/NSTEMI) present with a wide spectrum of risk for death and cardiac ischemic events...
  8. ncbi Association of hypoadiponectinemia with coronary artery disease in men
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 23:85-9. 2003
    ..This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD)...
  9. ncbi Major causes of death among men and women in China
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    N Engl J Med 353:1124-34. 2005
    ..We studied the major causes of death and modifiable risk factors in a nationally representative cohort of 169,871 men and women 40 years of age and older in China...
  10. ncbi Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials
    Richard J Sylvester
    EORTC Data Center, Brussels, Belgium
    Eur Urol 49:466-5; discussion 475-7. 2006
    ..To provide tables that allow urologists to easily calculate a superficial bladder cancer patient's short- and long-term risks of recurrence and progression after transurethral resection...
  11. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
    ..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
  12. ncbi Advanced methods in meta-analysis: multivariate approach and meta-regression
    Hans C van Houwelingen
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 21:589-624. 2002
    ..All analyses that use approximate likelihood can be carried out by standard software. We demonstrate how the models can be fitted using SAS Proc Mixed...
  13. doi Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    Paul Salama
    School of Surgery and Biostatistics Unit, Cancer Trials, Western Australian Institute for Medical Research, University of Western Australia, Australia
    J Clin Oncol 27:186-92. 2009
    ..To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities...
  14. pmc Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Brain Topogr 26:9-23. 2013
    ..generate regional volumes, cortical thickness measures and other measures, which can be used as input for multivariate analysis. It is not clear which combination of measures and normalization approach are most useful for AD ..
  15. ncbi Vitamin D levels and early mortality among incident hemodialysis patients
    M Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 72:1004-13. 2007
    ..Our study shows that among incident hemodialysis patients, vitamin D deficiency is common, correlates poorly with other components of mineral metabolism and is associated with increased early mortality...
  16. doi Combining multivariate voxel selection and support vector machines for mapping and classification of fMRI spatial patterns
    Federico De Martino
    Department of Cognitive Neurosciences, Faculty of Psychology, University of Maastricht, Maastricht, Postbus 616, 6200 MD, Maastricht, The Netherlands
    Neuroimage 43:44-58. 2008
    ..In line with the simulation results, our method outperforms univariate statistical analysis and statistical learning without feature selection...
  17. ncbi Derivation and validation of a short-form oral health impact profile
    G D Slade
    Department of Dental Ecology, University of North Carolina 27599-7450, USA
    Community Dent Oral Epidemiol 25:284-90. 1997
    ..In a multivariate analysis of dentate people, eight oral status and sociodemographic variables were associated (P < 0...
  18. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  19. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  20. ncbi Presentation of multivariate data for clinical use: The Framingham Study risk score functions
    Lisa M Sullivan
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02115, USA
    Stat Med 23:1631-60. 2004
    ..The system is also readily available to patients who can easily estimate their own coronary heart disease risk and monitor this risk over time...
  21. ncbi Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
    D R Bangsberg
    Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General Hospital, University of California San Francisco, 94110, USA
    AIDS 14:357-66. 2000
    ..To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless and marginally housed people on protease inhibitor (PI) therapy...
  22. ncbi Predictors of hospital mortality in the global registry of acute coronary events
    Christopher B Granger
    Division of Cardiology, University Medical Center, Durham, NC, USA
    Arch Intern Med 163:2345-53. 2003
    ..Management of acute coronary syndromes (ACS) should be guided by an estimate of patient risk...
  23. pmc Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
    ..We assessed the predictive value of FMD for incident CVD events in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  24. pmc Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases
    Charles M Balch
    Department of Surgery, Johns Hopkins Medical Institutions, 600 N Wolfe St, Osler 624, Baltimore, MD 21287, USA
    J Clin Oncol 28:2452-9. 2010
    ..To determine the survival rates and independent predictors of survival using a contemporary international cohort of patients with stage III melanoma...
  25. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  26. doi Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses
    Dan Jackson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 29:1282-97. 2010
    ..The method is applied to some real data sets and an extension to multivariate meta-regression is described...
  27. ncbi Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
    Eric L Knight
    Channing Laboratory, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 65:1416-21. 2004
  28. ncbi Functional magnetic resonance imaging (fMRI) "brain reading": detecting and classifying distributed patterns of fMRI activity in human visual cortex
    David D Cox
    Rowland Institute for Science, Cambridge, MA 02142, USA
    Neuroimage 19:261-70. 2003
  29. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  30. ncbi Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality
    Sin Ming Chow
    Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People s Republic of China
    Cancer 98:31-40. 2003
    ..The rising incidence of PMC among papillary thyroid carcinoma (PTC) necessitates the identification of prognostic factors and the formulation of treatment protocols...
  31. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  32. ncbi Burnout and self-reported patient care in an internal medicine residency program
    Tait D Shanafelt
    University of Washington, Veterans Affairs Northwest Health Services Research and Development Center of Excellence, and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann Intern Med 136:358-67. 2002
    ..Burnout is a syndrome of depersonalization, emotional exhaustion, and a sense of low personal accomplishment. Little is known about burnout in residents or its relationship to patient care...
  33. ncbi Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    N Engl J Med 348:203-13. 2003
    ..Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established...
  34. ncbi Partial directed coherence: a new concept in neural structure determination
    L A Baccala
    Telecommunications and Control Engineering, Escola Politecnica, University of Sao Paulo, Av Prof Luciano Gualberto, Trav 3, 158, CEP 05508 900, Brazil
    Biol Cybern 84:463-74. 2001
    ..The new concept is shown to reflect a frequency-domain representation of the concept of Granger causality...
  35. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  36. pmc HIV prevalence and associated risk factors among individuals aged 13-34 years in Rural Western Kenya
    Pauli N Amornkul
    Division of HIV AIDS Prevention, US Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 4:e6470. 2009
    ..To estimate HIV prevalence and characterize risk factors among young adults in Asembo, rural western Kenya...
  37. ncbi Nonlinear multivariate analysis of neurophysiological signals
    Ernesto Pereda
    Department of Basic Physics, College of Physics and Mathematics, University of La Laguna, Avda Astrofísico Fco Sánchez s n, 38205 La Laguna, Tenerife, Spain
    Prog Neurobiol 77:1-37. 2005
    ..Finally, we illustrate the use of multivariate surrogate data test for the assessment of the strength (strong or weak) and the type (linear or nonlinear) of interdependence between neurophysiological signals...
  38. doi A gene expression signature identifies two prognostic subgroups of basal breast cancer
    Renaud Sabatier
    Département d Oncologie Moléculaire, Centre de Recherche en Cancerologie de Marseille, UMR891 Inserm, Institut Paoli Calmettes, Marseille, France
    Breast Cancer Res Treat 126:407-20. 2011
    ..93E-05). The classifier outperformed the classical prognostic variables in multivariate analysis, conferring lesser risk for relapse in subgroup 1 (HR = 0.52, P = 3.9E-04)...
  39. ncbi Analysis of radiation-induced liver disease using the Lyman NTCP model
    Laura A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 53:810-21. 2002
    ..To describe the dose-volume tolerance for radiation-induced liver disease (RILD) using the Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) model...
  40. pmc A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis
    Ashley Busacker
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA
    Chest 135:48-56. 2009
    ..measured by multidetector CT (MDCT) quantitative methodology would be a predictor of a more severe asthma phenotype; and (2) historical, clinical, allergic, or inflammatory risk factors could be identified via multivariate analysis.
  41. doi Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 27:3757-63. 2009
    ..Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity...
  42. pmc Missing covariate data within cancer prognostic studies: a review of current reporting and proposed guidelines
    A Burton
    Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT, UK
    Br J Cancer 91:4-8. 2004
    ..Guidelines for presenting prognostic studies with missing covariate data are proposed, which if followed should clarify and standardise the reporting in future articles...
  43. ncbi Genomic aberrations and survival in chronic lymphocytic leukemia
    H Dohner
    Department of Internal Medicine III University of Ulm, Germany
    N Engl J Med 343:1910-6. 2000
    ..We used this method to identify chromosomal abnormalities in patients with chronic lymphocytic leukemia and assessed their prognostic implications...
  44. pmc Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients
    Sandra Steffens
    Department of Urology, Hannover Medical School, Carl Neuberg Str, 1, D 30625, Hannover, Germany
    BMC Cancer 12:399. 2012
    ..To evaluate the prognostic significance of the pre-operative C-reactive protein (CRP) serum level in patients with renal cell cancer (RCC)...
  45. ncbi Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study
    J R Ickovics
    Yale University, Department of Epidemiology and Public Health, PO Box 208034, 60 College St, Suite 415, New Haven, CT 06520 8034, USA
    JAMA 285:1466-74. 2001
    ..The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts...
  46. ncbi A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
    R M Salek
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Physiol Genomics 29:99-108. 2007
  47. pmc Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA
    Mohamed F Elshal
    National Heart, Lung, and Blood Institute, NIH Bethesda, MD 20892, USA
    Methods 38:317-23. 2006
    ..By careful consideration of these variables, it should be possible to utilize multiplex bead array assays in lieu of ELISAs for studies requiring high throughput analysis of numerous analytes...
  48. ncbi Cancer control with radical prostatectomy alone in 1,000 consecutive patients
    Gerald W Hull
    Department of Urology, Medical University of South Carolina, Charleston, USA
    J Urol 167:528-34. 2002
    ..We analyzed the long-term progression-free probability after radical retropubic prostatectomy in a consecutive series of patients with localized prostate cancer...
  49. ncbi Follicular lymphoma international prognostic index
    Philippe Solal-Celigny
    Centre Jean Bernard, 9 rue Beauverger, 72000 Le Mans, France
    Blood 104:1258-65. 2004
    ..Results were very similar in the confirmation group. The FLIPI may be used for improving treatment choices, comparing clinical trials, and designing studies to evaluate new treatments...
  50. ncbi A novel simpler histological classification for renal survival in IgA nephropathy: a retrospective study
    Carlo Manno
    Department of Emergency and Organ Transplantation, Renal, Dialysis and Transplant Unit, University of Bari, Bari, Italy
    Am J Kidney Dis 49:763-75. 2007
    ..We evaluated factors associated with long-term renal survival by using a novel simplified histological classification...
  51. pmc Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence
    Giorgio Ercolani
    Department of Surgery and Transplantation, Surgical Unit, S Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Ann Surg 237:536-43. 2003
    ..To evaluate prognostic factors that could affect disease-free survival and recurrence after liver resection for hepatocellular carcinoma (HCC) on cirrhosis...
  52. ncbi Multivariate meta-analysis
    In Sun Nam
    Queensland University of Technology, Australia
    Stat Med 22:2309-33. 2003
    ..Our preferred method is then illustrated through an analysis of a new data set on parental smoking and two health outcomes (asthma and lower respiratory disease) in children...
  53. ncbi Normal fasting plasma glucose levels and type 2 diabetes in young men
    Amir Tirosh
    Medical Corps Headquarters, Tel Hashomer, Israel
    N Engl J Med 353:1454-62. 2005
    ..55 mmol per liter). Whether higher fasting plasma glucose levels within this range independently predict type 2 diabetes in young adults is unclear...
  54. doi Trabectedin plus pegylated liposomal Doxorubicin in recurrent ovarian cancer
    Bradley J Monk
    University of California at Irvine UCI and UCI Medical Center, Orange, CA 92868 3298, USA
    J Clin Oncol 28:3107-14. 2010
  55. doi Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR
    Athina Markou
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece
    Clin Chem 54:1696-704. 2008
    ..We evaluated the prognostic value of mature microRNA-21 (miR-21) and mature microRNA-205 (miR-205) overexpression in non-small cell lung cancer (NSCLC)...
  56. ncbi The diabetes risk score: a practical tool to predict type 2 diabetes risk
    Jaana Lindström
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:725-31. 2003
    ..Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes Risk Score...
  57. doi Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain
    Clin Infect Dis 50:40-8. 2010
    ..We investigated the prevalence and risk factors for COBSI due to ESBLEC, and described their clinical features and the impact of COBSI caused by ESBLEC on 14-day mortality...
  58. ncbi Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    Mitch Dowsett
    Academic Department of Biochemistry, 4th Floor, Wallace Wing, The Royal Marsden Hospital, Fulham Road, London SW3 6 JJ, UK
    J Natl Cancer Inst 99:167-70. 2007
  59. ncbi MADE4: an R package for multivariate analysis of gene expression data
    Aedin C Culhane
    Bioinformatics, Conway Institute, University College Dublin, Dublin 4, Ireland
    Bioinformatics 21:2789-90. 2005
    MADE4, microarray ade4, is a software package that facilitates multivariate analysis of microarray gene-expression data. MADE4 accepts a wide variety of gene-expression data formats...
  60. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..01 and P<0.0001, respectively). In multivariate analysis, pulse wave velocity remained significantly associated with the occurrence of coronary event after ..
  61. ncbi Health literacy and knowledge of chronic disease
    Julie A Gazmararian
    Department of Health Policy and Management, Emory Center on Health Outcomes and Quality, Rollins School of Public Health of Emory University, 6th Floor, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Patient Educ Couns 51:267-75. 2003
    ..b>Multivariate analysis indicated that health literacy was independently related to disease knowledge...
  62. pmc Impact of antiretroviral therapy on incidence of pregnancy among HIV-infected women in Sub-Saharan Africa: a cohort study
    Landon Myer
    Centre for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    PLoS Med 7:e1000229. 2010
    ..However there are few data on whether ART initiation influences pregnancy rates...
  63. ncbi Performance of the modification of diet in renal disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease
    Emilio D Poggio
    Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, A51, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Soc Nephrol 16:459-66. 2005
    ..This study also emphasizes the complexity of laboratory calibration of serum creatinine measurements, a determining factor when estimating GFR in both healthy individuals and CKD patients with preserved GFR...
  64. ncbi Prevalence of HPV infection among females in the United States
    Eileen F Dunne
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 297:813-9. 2007
    ..Baseline population prevalence data for HPV infection in the United States before widespread availability of a prophylactic HPV vaccine would be useful...
  65. ncbi Women's status and domestic violence in rural Bangladesh: individual- and community-level effects
    Michael A Koenig
    Department of Population and Family Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Demography 40:269-88. 2003
  66. ncbi Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    R C Turner
    Radcliffe Infirmary, Oxford, England
    JAMA 281:2005-12. 1999
    ..8 mmol/L (140 mg/dL) or glycosylated hemoglobin A1c (HbA1c) below 7% is unknown...
  67. pmc Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients
    Pablo Perel
    London School of Hygiene and Tropical Medicine, London WC1B 3DP
    BMJ 336:425-9. 2008
    ..To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury...
  68. pmc Predicting the risk for dialysis or death in IgA nephropathy
    Francois Berthoux
    Nephrology, Dialysis, and Renal Transplantation Department, University North Hospital, 42055 Saint Etienne Cedex 2, France
    J Am Soc Nephrol 22:752-61. 2011
    ..When achieved, control of hypertension and reduction of proteinuria reduced the risk for death or dialysis. In conclusion, the absolute renal risk score, determined at diagnosis, associates with risk for dialysis or death...
  69. ncbi Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  70. pmc Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 39:1731-43. 2008
    ..High-dimensional pattern classification, a nonlinear multivariate analysis, provided measures of structural abnormality that can potentially be useful for individual patient ..
  71. ncbi Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy
    W Fraser Symmans
    Department of Pathology, Unit 85, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 25:4414-22. 2007
    ..To measure residual disease after neoadjuvant chemotherapy in order to improve the prognostic information that can be obtained from evaluating pathologic response...
  72. pmc Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    ..We examined the HCC risk associated with HBV genotypes and common variants in the precore and basal core promoter (BCP) regions...
  73. pmc Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
    Anne Thea McGill
    University of Auckland Human Nutrition Unit, University of Auckland, Auckland, New Zealand
    Nutr J 7:4. 2008
    ..In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se...
  74. ncbi Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study
    Henrik Watz
    Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Am J Respir Crit Care Med 177:743-51. 2008
    ..Physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD). COPD has a systemic component that includes significant extrapulmonary effects that may contribute to its severity in individual patients...
  75. ncbi Chemometrics in metabonomics
    Johan Trygg
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Sweden
    J Proteome Res 6:469-79. 2007
    ..This is illustrated by examples from the literature...
  76. ncbi Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy
    Norio Akuta
    Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
    Intervirology 48:372-80. 2005
    ..Non-virological responders (NVRs, namely ultimate resistant cases) who do not achieve HCV-RNA negativity during treatment are also encountered. We investigated the pretreatment virological features of NVRs...
  77. ncbi Beyond mind-reading: multi-voxel pattern analysis of fMRI data
    Kenneth A Norman
    Department of Psychology, Princeton University, Green Hall, Washington Road, Princeton, NJ 08540, USA
    Trends Cogn Sci 10:424-30. 2006
    ..We review how researchers are using MVPA methods to characterize neural coding and information processing in domains ranging from visual perception to memory search...
  78. ncbi Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 347:1557-65. 2002
    ..Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available...
  79. ncbi Chronic kidney disease and mortality risk: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2034-47. 2006
    ..0 in 71% of cohorts. This review supports current guidelines that identify individuals with CKD as being at high risk for cardiovascular mortality. Determining which interventions best offset this risk remains a health priority...
  80. doi Severe anemia in Malawian children
    Job C J Calis
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    N Engl J Med 358:888-99. 2008
    ..Severe anemia is a major cause of sickness and death in African children, yet the causes of anemia in this population have been inadequately studied...
  81. ncbi Gestational weight gain and adverse neonatal outcome among term infants
    Naomi E Stotland
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco General Hospital, San Francisco, California 94110, USA
    Obstet Gynecol 108:635-43. 2006
    ..To examine the relationship between gestational weight gain and adverse neonatal outcomes among infants born at term (37 weeks or more)...
  82. ncbi Prognostic factors in non-small cell lung cancer: a decade of progress
    Michael D Brundage
    Department of Oncology, Radiation Oncology Research Unit, Queen s University, Kingston, ON, Canada
    Chest 122:1037-57. 2002
  83. ncbi The effects of social status on biological aging as measured by white-blood-cell telomere length
    L F Cherkas
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK, and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
    Aging Cell 5:361-5. 2006
    ..Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length...
  84. ncbi Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
  85. ncbi A multivariate analysis approach to the integration of proteomic and gene expression data
    Ailís Fagan
    Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    Proteomics 7:2162-71. 2007
    ..In each case, we visualise gene expression, protein abundance and GO classes in the same low dimensional projections and identify GO classes that are likely to be of biological importance...
  86. pmc Multivariate analysis of maize disease resistances suggests a pleiotropic genetic basis and implicates a GST gene
    Randall J Wisser
    Department of Plant and Soil Sciences, University of Delaware, Newark, DE 19716 1304, USA
    Proc Natl Acad Sci U S A 108:7339-44. 2011
    ..The known functions of GSTs suggested that variability in detoxification pathways underlie natural variation in maize MDR...
  87. ncbi Distance-based tests for homogeneity of multivariate dispersions
    Marti J Anderson
    Department of Statistics, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biometrics 62:245-53. 2006
    ..Monte Carlo simulations from the real data sets show that the distance-based tests are robust and powerful for relevant alternative hypotheses of real differences in spread...
  88. ncbi Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients
    Nicole M Kuderer
    James P Wilmot Cancer Center and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Cancer 106:2258-66. 2006
    ..The study was undertaken to better define mortality, length of stay (LOS), cost, and risk factors associated with mortality and prolonged hospitalization in cancer patients with FN...
  89. pmc Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    Yujin Hoshida
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    N Engl J Med 359:1995-2004. 2008
    ..An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissue...
  90. doi Get With the Guidelines-Stroke is associated with sustained improvement in care for patients hospitalized with acute stroke or transient ischemic attack
    Lee H Schwamm
    Massachusetts General Hospital, Boston, MA 02114, USA
    Circulation 119:107-15. 2009
    ..Adherence to evidence-based guidelines for treatment of stroke or transient ischemic attack is suboptimal. We sought to establish whether participation in Get With the Guidelines-Stroke was associated with improvements in adherence...
  91. doi Multiple imputation for missing data: fully conditional specification versus multivariate normal imputation
    Katherine J Lee
    Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Am J Epidemiol 171:624-32. 2010
    ..These results provide reassurance that similar results can be expected from FCS and MVNI in a standard regression analysis involving variously scaled variables...
  92. doi Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma
    Hanne Krogh Jensen
    Department of Oncology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    J Clin Oncol 27:4709-17. 2009
    ..We have previously demonstrated a significant negative impact of intratumoral neutrophils in metastatic renal cell carcinoma. This study assessed intratumoral neutrophils in localized clear cell renal cell carcinoma (RCC)...
  93. ncbi Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
  94. pmc The ratio between metastatic and examined lymph nodes (N ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1853 patients
    Alberto Marchet
    Clinica Chirurgica Generale 2, University of Padova, Padova, Italy
    Ann Surg 245:543-52. 2007
  95. ncbi The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis
    M Isabel T D Correia
    Department of Surgery, Faculdade de Medicina da, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Clin Nutr 22:235-9. 2003
    ..9%. It was concluded that malnutrition, as analyzed by a multivariate logistic regression model, is an independent risk factor impacting on higher complications and increased mortality, length of hospital stay and costs...
  96. pmc Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas
    Isabelle Ray-Coquard
    Université de Lyon Centre Léon Bérard, Department of Medical Oncology and EA SIS 4128, Lyon, France
    Cancer Res 69:5383-91. 2009
    ..01), and non-Hodgkin lymphoma (median, 11 versus 94 months; P < 0.0001). In multivariate analysis (Cox model), lymphopenia was an independent prognostic factor for overall survival in metastatic breast ..
  97. ncbi The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis
    Bachti Alisjahbana
    Internal Medicine, Medical Faculty, Padjadjaran University, Bandung, Indonesia
    Clin Infect Dis 45:428-35. 2007
    ..Presently, little is known about the effect of DM on the clinical presentation and treatment outcome of TB...
  98. ncbi C-reactive protein is an informative predictor of renal cell carcinoma-specific mortality: a European study of 313 patients
    Pierre I Karakiewicz
    Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    Cancer 110:1241-7. 2007
    ..It was hypothesized that CRP can improve the prognostic ability of standard RCC-specific mortality (RCC-SM) predictors in patients treated with nephrectomy for all stages of RCC...
  99. ncbi Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    A M Wallace
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Circulation 104:3052-6. 2001
    ..18; 95% CI, 1.00 to 1.39; P=0.05) at the expense of C-reactive protein. CONCLUSIONS: We show, for the first time, in a large prospective study that leptin is a novel, independent risk factor for coronary heart disease...
  100. ncbi Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients
    P Vercellini
    First Department of Obstetrics and Gynaecology, University of Milano, Italy
    Hum Reprod 22:266-71. 2007
  101. doi Decoding an individual's sensitivity to pain from the multivariate analysis of EEG data
    Enrico Schulz
    Department of Neurology, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Cereb Cortex 22:1118-23. 2012
    ..Beyond, our approach may help to establish an objective neuronal marker of pain sensitivity which can potentially be recorded from a single EEG electrode...

Research Grants66

  1. A Prospective Study of Diet and Prostate Cancer
    Edward Giovannucci; Fiscal Year: 2011
    ..We will use multivariate analysis to control for confounding factors...
  2. Growth and Cardiometabolic Risk Among In Utero Drug Exposed Children
    SARAH ELIZABETH MESSIAH; Fiscal Year: 2013
    ..determine the specific effects of both prenatal and postnatal exposures of cocaine in a repeated measures multivariate analysis, controlling for effect modifiers (nicotine, alcohol and marijuana exposure, stress, anxiety and ..
  3. Durable Visible Light-activated Antivral Coatings for Fabrics Used for Personal P
    JOSEF STEPHAN SCHNEIDER; Fiscal Year: 2011
    ..Hong Kong showed that wearing masks in public was independently associated with protection from SARS in a multivariate analysis. However, a study performed by the CDC showed definitive evidence of the transmission of virus particles ..
  4. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..The outcome for Hispanics was intermediate between that for Caucasians and African-Americans. Multivariate analysis revealed racial/ethnic background to be independently associated with decreased EFS, even after ..
  5. Energy Balance-Related Hormones &Prostate Cancer Incidence &Progression
    Edward Giovannucci; Fiscal Year: 2012
    ..Stratified analysis and multivariate analysis will be used to control for confounding factors...
  6. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
    ..cardiovascular and prostate-related disease will be determined, categorized and controlled for in the multivariate analysis. In addition to conventional proportional hazards models a Propensity Score Analysis and/or an ..
  7. Effect of Crohn's Disease Risk Alleles on Enteric Microbiota
    Ellen Li; Fiscal Year: 2010
    ..Quantitative PCR will be performed to quantify specific microbial subgroups. Multivariate analysis of the metagenomic data and the genotyping data will include potentially confounding variables such as age,..
  8. Multivariate Analysis of the Total Fertility Rate and Its Components
    Robert D Retherford; Fiscal Year: 2010
    This application proposes a new method of multivariate analysis of the total fertility rate (TFR) and its components, applied to individual-level survey or census data...
  9. Korean Immigrants & Mammography-Culture-Specific Health Intervention (KIM-CHI)
    Eunice E Lee; Fiscal Year: 2010 and breast self-examination (BSE) practice at 2 weeks and 15 months using repeated measures multivariate analysis of variance;and (3) identify the mediating effects of health beliefs, knowledge, self-efficacy, spousal ..
  10. Integrative Analysis of Change in Cognition and Health
    Scott M Hofer; Fiscal Year: 2011
    ..features include inference to defined populations of aging individuals conditional on mortality-selection, multivariate analysis of correlated and coupled change, estimation of change-points, and cross-national generalizability...
  11. The relationship between pets and multiple child health indicators
    ANNE M GADOMSKI; Fiscal Year: 2013
    ..b>Multivariate analysis will be performed to control for significant covariats in bivariate analysis...
  12. Immune response to pneumococcal vaccination in aging HIV positive adults.
    M A JULIA WESTERINK; Fiscal Year: 2013
    ..risk for IPD based on their immune deficiencies secondary to HIV AND immunosenescence as suggested using multivariate analysis. Although there is considerable overlap in B cell alterations caused by HIV and by aging we have recently ..
  13. Functional Architecture of Human Speech Motor Cortex
    Edward Chang; Fiscal Year: 2011
    ..of speech motor control;Human Neurophysiology, where insight gained may suggest novel methods for multivariate analysis of distributed population neural activity;and Translational NeuroEngineering, where results will apply ..
  14. Basic mechanisms in arteriovenous fistula maturation for hemodialysis
    EUGENE SANGKEU LEE; Fiscal Year: 2013
    ..7 Transwell assays of monocyte transendothelial migration and endothelial permeability 7 Biostatistics: Multivariate analysis and survival analysis (vein maturation and duration) 7 Patient management and case report form management...
  15. Near Infrared Brain Imaging for Guiding Treatment in Children with Cerebral Palsy
    Georgios Alexandrakis; Fiscal Year: 2013
    ..b>Multivariate analysis between fNIR metrics and functional performance measures will be performed pre- and post-treatment to test ..
  16. Preterm Fetal Growth Restriction and Developmental Care
    Heidelise Als; Fiscal Year: 2009
    ..Repeated measures multivariate analysis of variance by domain will be employed to assess sample, group and time effects as well as their ..
  17. Enhancing physical activity after breast cancer diagnosis: randomized trial
    Laura Q Rogers; Fiscal Year: 2012 analyzed with mixed-model analysis of variance (ANOVA) with the secondary study aim #1 also utilizing multivariate analysis of variance (MANOVA) and Freedman- Schatzkin difference-in-coefficients test of mediation...
  18. Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma Detection
    David E Misek; Fiscal Year: 2013
    ..We will use multivariate analysis techniques, including hierarchical clustering (HC) and principal components analysis (PCA), to identify ..
  19. Development of novel detection and prediction algorithms for Microcystis blooms
    Timothy Moore; Fiscal Year: 2013
    ..This data set will guide the development of an innovative ecological niche model based on multivariate analysis that will predict the spatial and temporal distribution of imminent HAB events from real-time ..
  20. Early Detection of Keratoconus
    Ronald H Silverman; Fiscal Year: 2013
    ..We will develop an index based on multivariate analysis of these patterns based on unambiguously classified cases, and validate the risk index on suspicious cases ..
  21. High sensitivity Troponin T as a novel predictor of cardiovascular events
    ALEXIS LYNN BEATTY; Fiscal Year: 2012
    ..between baseline hs-cTnT and cardiovascular events in participants with chronic IHD by performing multivariate analysis with adjustment for baseline characteristics...
  22. Moral Hazard in Less Invasive Surgical Technology for Coronary Artery Disease
    Michael Grossman; Fiscal Year: 2011
    ..Each survey will be linked to Medicare claims files and to the National Death Index. The multivariate analysis will be based on difference-in-differences and propensity score matching methods...
  23. Effect of Cocaine and LTR Polymorphism on HIV-1 Pathogenesis
    Richard B Markham; Fiscal Year: 2013
    ..Using diversity, resistance mutations to PI and viral load as outcomes, we will examine using a multivariate analysis, the effect of cocaine use, immediate early gene expression levels, AP-1 quantities, and the presence of ..
  24. Noninvasive assessment of embryo implantation potential using 1H NMR metabonomics
    Paolo Rinaudo; Fiscal Year: 2010
    ..Our preliminary studies based on proton nuclear magnetic resonance spectroscopy (1H-NMR) show that multivariate analysis of the NMR spectra recorded for culture media samples from 100% and 0% implantation cases revealed a ..
  25. Should Smokeless Tobacco be Promoted as an Alternative for Smokers ?
    David Timberlake; Fiscal Year: 2013
    ..Size of the population will also determine whether a descriptive or multivariate analysis is employed for the statistical methods...
  26. PS07-003, Minority HIV/AIDS Research Initiative
    JOSE EDUARDO NANIN; Fiscal Year: 2011
    ..e., respondent- driven sampling). Data analyses will utilize multivariate analysis techniques (i.e...
  27. Development of a new Imaging Platform for Pharmaceutical and Biomedical applicati
    Lynne S Taylor; Fiscal Year: 2012
    ..Uni- and multivariate analysis will be employed on drug-polymer systems with different dispersion states...
  28. Enhancing physical activity after breast cancer diagnosis: randomized trial
    Laura Q Rogers; Fiscal Year: 2013 analyzed with mixed-model analysis of variance (ANOVA) with the secondary study aim #1 also utilizing multivariate analysis of variance (MANOVA) and Freedman- Schatzkin difference-in-coefficients test of mediation...
  29. Center for Nanobiology and Predictive Toxicology
    ANDRE ELIAS NEL; Fiscal Year: 2013 a dose-dependent fashion (Project 2);(iv) To develop in silico toxicity models that utilize multivariate analysis of the rapid throughput screening and cellular imaging data to show the relationships that can be used to ..
  30. Pharmacoepidemiology of Urologic Symptoms
    SUSAN AUDREY HALL; Fiscal Year: 2010
    ..We will use multivariate analysis methods and population restriction to account for other risk factors for the outcomes of interest, ..
  31. A Sjogrens Syndrome Diagnostic
    KATHY L SIVILS; Fiscal Year: 2012
    ..In this study, we will use genome-wide expression profiling of peripheral blood leukocytes coupled with multivariate analysis to identify SS diagnostic biomarkers of disease...
  32. ED Visits and Hospitalizations for Preventable Conditions: Determinants and Costs
    Sophia Terp; Fiscal Year: 2013
    ..we will establish the impact of PCP density on rates of ED encounters and hospitalizations for ACSC using multivariate analysis and a county-level fixed-effects model...
  33. Brain pathways in social evaluative threat
    TOR DESSART WAGER; Fiscal Year: 2010
    ..This project combines advanced multivariate analysis techniques with cutting-edge methods for imaging the brainstem to map these pathways, providing insight ..
  34. Co-expression Networks of Addiction-Related Genes in the Mouse and Human Brain
    PARTHA PRATIM MITRA; Fiscal Year: 2012
    ..and refinement of software and web-based tools for analysis of co-expression patterns in gene sets and (2) multivariate analysis of an initial set of addiction related genes...
  35. Prevalence and Risk Factors for Anal Human Papillomavirus in Heterosexual Men: Th
    Alan Nyitray; Fiscal Year: 2009
    ..In multivariate analysis, number of lifetime sexual partners and frequency of sex was independently associated with anal HPV...
  36. Optimal & Equitable Care: Medicaid Data Research Infrastructure
    GEORGE S RUST; Fiscal Year: 2010
    ..institutions) as independently-funded health services researchers who are increasingly proficient in multivariate analysis of Medicaid and Medicare claims data. 4...
  37. Functional Outcomes After Major Surgery in Nursing Home Residents
    Emily Finlayson; Fiscal Year: 2010
    ..Aim III. To better predict surgical outcomes in nursing home patients. Using multivariate analysis, we will evaluate how patients'age, medical comorbidities, preoperative functional status and ..
  38. Parental Involvement as a Strategy to Enhance Adolescent Weight Control
    Elissa Jelalian; Fiscal Year: 2010
    ..Separate multivariate analysis of variance (MANOVA) will be used to evaluate parent healthy weight strategies and combined questionnaire ..
  39. Multivariate Analysis of Candidate Blood Pressure Response Genes in Hypertensives
    Andrei Rodin; Fiscal Year: 2010
    ..However, the scope of these analyses was very limited. We intend to follow up with the multivariate analysis in order to gain the systemic understanding of the dataset and the underlying biological pathways...
  40. Peripheral Biomarkers in Familial Alzheimer's Disease
    Paul Coleman; Fiscal Year: 2009
    ..provided by applicant): Our previous studies (presented in Preliminary Results) have shown that multivariate analysis of transcripts related to inflammatory response and to cellular stress can distinguish Alzheimer's ..
  41. Improvements to Respondent-Driven Sampling for the Study of Hidden Populations
    Matthew J Salganik; Fiscal Year: 2011
    ..RDS sample size calculation to ensure that studies have the desired level of statistical power;2) develop multivariate analysis procedures for RDS data;and 3) develop diagnostics to assess whether the assumptions behind RDS have been ..
  42. Content representation in the human medial temporal lobe
    JACKSON CHIT LIANG; Fiscal Year: 2012
    ..b>Multivariate analysis of patterned activation during timepoints before expected events will test whether they carry information ..
    Richard Semba; Fiscal Year: 2001
    ..03). Vitamin A significantly reduced low birth weight in a multivariate analysis controlling for maternal age, body mass index, and CD4+ count...
    David G Castner; Fiscal Year: 2013
    ..Development of multivariate analysis methods will be important for both spectroscopic and image analysis...
  45. Predictors of ART Adherence for Behaviorally-Infected HIV+ African-American Males
    ISRAEL GROSS; Fiscal Year: 2013
    ..for HIV/AIDS Interventions (ATN) 086 protocol in 2010-2011, will be investigated using an exploratory multivariate analysis technique known as Optimal Data Analysis (ODA)...
  46. Improving the Detection of Activation in High Resolution fMRI using Multivariate
    Dietmar Cordes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall goal of this project is to develop a local multivariate analysis software package for fMRI data analysis...
  47. HYBRID Diffusion Imaging to Detect Acute White Matter Injury After Mild TBI
    Yu Chien Wu; Fiscal Year: 2012
    ..A general linear model approach including multivariate analysis of variance (MANOVA) and covariance (MANCOVA) will be used to assess the correlation between observed ..
    John Blangero; Fiscal Year: 2010
    ..The investigators will develop and extend the variance component linkage procedures to allow for general multivariate analysis, oligogenic inheritance, epistasis, genotype x environment interaction, and empirical genome-wide p-value ..
  49. Drugs, sexual impulsivity, HIV: Psychosocial and cognitive risk factors of YMSM
    DORIAN E TRAUBE; Fiscal Year: 2010
    ..Using data from the Dr. Kipke's NIDA funded "Healthy Young Men Study" (HYM), this study will conduct multivariate analysis to test this model for use with the YMSM population...
    JOEL RUDNEY; Fiscal Year: 2001
    ..2.) Apply those methods to screen unstimulated whole saliva from 170 dental students. Multivariate analysis will be used to group subjects opposite for cell-killing, aggregation, and adherence. 3...
  51. Quantitiative MRI of prostate cancer as a biomarker and guide for treatment
    Fiona Fennessy; Fiscal Year: 2013
    ..We will perform a multivariate analysis of the results of the analyses tools, and patient-specific parameter maps for tumor localization (a ..
  52. The Role of Cerebral Hemodynamics in Moya Moya Disease
    COLIN PIETER DERDEYN; Fiscal Year: 2010
    ..We will also do a multivariate analysis to determine the independent predictors of stroke in this sample...
  53. Changes in Category Selectivity in Visual Association Cortex After PFC Impairment
    Emi M Nomura; Fiscal Year: 2010
    ..Further, a multivariate analysis of the fMRI data obtained in the two previously described proposed experiments will identify changes in ..
    Mamoun Younes; Fiscal Year: 2005
    ..using the development of HGD and CA as end points in separate analyses, and evaluated by univariate and multivariate analysis. The sensitivity, specificity, and positive and negative predictive value of each of these markers as ..
  55. Long Term Functional Outcomes of Early TBI
    Shari L Wade; Fiscal Year: 2013
    ..Differences between the TBI and OI groups will be analyzed by means of univariate or multivariate analysis of covariance...
  56. Neural basis of cognitive reserve: fMRI/TMS studies of memory and aging
    Bruce Luber; Fiscal Year: 2012
    ..neural reserve and compensation networks related to working memory in the elderly using fMRI and advanced multivariate analysis comparing young and older adults (Aim 1), and to validate the functional role of neural reserve (Aim 2) ..
  57. Quantitative Spectroscopic Imaging of Cancer Metabolites in Live Cells and Intact
    Ji Xin Cheng; Fiscal Year: 2013
    ..In Aim 1, we will develop multiplex stimulated Raman loss (SRL) microscopy and multivariate analysis algorithm to enable quantitative vibrational imaging of lipid metabolites in live cells...
  58. Sleep disorders and QOL in lung cancer survivors
    Nalaka Gooneratne; Fiscal Year: 2009
    ..An important developmental aspect of the protocol is that the investigators will conduct exploratory multivariate analysis. This will be used to provide more accurate point estimates for sample size calculations for the design of ..
    Larry Bumpass; Fiscal Year: 2000
    ..Countries will be grouped according to similarities with respect to age and education effects and multivariate analysis will be explored in the spirit of multiple standardization...
    Sue Thomas; Fiscal Year: 2002
    ..8, using logistic multiple regression, linear multiple regression, chi-square, and multivariate analysis of variance. Heart failure affects 1-2 million people in the United States...
    Morteza Khaledi; Fiscal Year: 2003
    ..the multidimensional nature of these problems, we will investigate the usefulness of the factor - based, multivariate analysis chemometric techniques such as principal component regression and partial least square in QRAR modeling...
    Keela Herr; Fiscal Year: 1999
    ..significance tests for differences in proportions, linear regression correlations, factor analyses and multivariate analysis of variance...
    William Hueston; Fiscal Year: 1992
    ..Using multivariate analysis of variance, physician specialty will be compared with other demographic and clinical factors that may ..
    Brent Vogt; Fiscal Year: 2002
    ..Also, studies of posterior cingulate cortex fail to confirm the common endpoint hypothesis and multivariate analysis of neurons showed that small-medium pyramids in layers IIIab and IV are often impacted, there is no single ..
    CYNTHIA SELASSIE; Fiscal Year: 1992
    ..Abstract): The object of the proposed research is to combine the methods of physical organic chemistry, multivariate analysis and molecular graphics in the search for more effective and selective antibacterial and antiprotozoal ..
  66. Bronchial Reactivity and the Course of Lung Function After WTC Exposure
    Thomas K Aldrich; Fiscal Year: 2013
    ..decline rates in subgroups with or without OAD and with high or normal bronchial reactivity, and by multivariate analysis. The results should define the natural history of WTC-associated OAD, determine whether clinical outcomes ..